Eric Ortlund PhD

Department of Biochemistry
Professor

Emory University
Biochemistry
1510 Clifton Rd. NE Room 4017

Overview

Dr. Ortlund is a Professor of Biochemistry at Emory University School of Medicine. His lab uses structural, biochemical and biophysical approaches to study lipid signaling, transcriptional control and host-pathogen interactions. He is the Scientific Director of the Emory Integrated Metabolomics and Lipidomics Core.

Academic Appointment

Vice Chair of Biochemistry, Biochemistry, Emory University School of Medicine
Professor, Biochemistry, Emory University School of Medicine

Education

Degrees

PhD from University of South Carolina
BS from University of South Carolina

Research

Publications

The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases.
Nat Commun Volume: 16 Page(s): 6147
07/04/2025 Authors: Sastre DE; Bournazos S; Huliciak M; Grace BAC; Boder EJ; Du J; Sultana N; Azzam T; Brown TJ; Flowers MW
Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.
bioRxiv
05/19/2025 Authors: Kelty TJ; Franczak E; Gay NR; Many GM; Sagendorf TJ; Sanford JA; Hou Z; Gaul DA; Fernndez FM; Burant C
Mapping affinity and allostery in human IgG antibody Fc region-Fc receptor interactions.

04/01/2025 Authors: Keith AD; Xu T; Chernova TA; Keen MM; Bogacz M; Nedeljkovi M; Flowers M; Brown T; Frank F; Ortlund EA
Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans.
bioRxiv
03/24/2025 Authors: Iturria-Medina Y; Poole VN; Zammit AR; Yu L; Tasaki S; Hong JH; Lopes KDP; Batalha C; Ridwan AR; Vialle RA
The Design and Immunogenicity of an HIV-1 Clade C Pediatric Envelope Glycoprotein Stabilized by Multiple Platforms.
Vaccines (Basel) Volume: 13
01/22/2025 Authors: Kumar S; Moral-Snchez ID; Singh S; Newby ML; Allen JD; Bijl TPL; Vaghani Y; Jing L; Lodha R; Ortlund EA
Epitope mapping via invitro deep mutational scanning methods and its applications.
J Biol Chem Volume: 301 Page(s): 108072
01/01/2025 Authors: Keen MM; Keith AD; Ortlund EA
Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog.
J Biol Chem Volume: 301 Page(s): 108074
01/01/2025 Authors: Weinberg J; Liu KH; Lee C-M; Crandall WJ; Cuevas AR; Druzak SA; Morgan ET; Jarrell ZR; Ortlund EA; Martin GS
Structural dynamics and binding of Caenorhabditis elegans lifespan-extending lipid binding protein-3 to polyunsaturated fatty acids.
Protein Sci Volume: 34 Page(s): e5249
01/01/2025 Authors: Cuevas AR; Tillman MC; Wang MC; Ortlund EA
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose.
NPJ Vaccines Volume: 9 Page(s): 255
12/23/2024 Authors: Rostad CA; Yildirim I; Kao C; Yi J; Kamidani S; Peters E; Stephens K; Gibson T; Hsiao H-M; Singh K
Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
Nature Volume: 636 Page(s): E9
12/01/2024 Authors: Blanchard JW; Akay LA; Davila-Velderrain J; von Maydell D; Mathys H; Davidson SM; Effenberger A; Chen C-Y; Maner-Smith K; Hajjar I
Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk.
Nat Commun Volume: 15 Page(s): 10201
11/25/2024 Authors: Oshinowo O; Copeland R; Patel A; Shaver N; Fay ME; Jeltuhin R; Xiang Y; Caruso C; Otumala AE; Hernandez S
Endurance Exercise Training Alters Lipidomic Profiles of Plasma and Eight Tissues in Rats: a MoTrPAC study.

11/21/2024 Authors: Ortlund E; Hou Z; Chen C-Y; Gaul D; Zhang T; Moore S; Liu X; Ivanova A; Maner-Smith K; Newgard C
Activity and phosphatidylcholine transfer protein interactions of skeletal muscle thioesterase Them2 enable hepatic steatosis and insulin resistance.
J Biol Chem Volume: 300 Page(s): 107855
11/01/2024 Authors: Xie Y; Liu X; Liu W; Carr LR; Lee LP; Imai N; Ortlund EA; Cohen DE
Design and immunogenicity of an HIV-1 clade C pediatric envelope glycoprotein stabilized by multiple platforms.

09/19/2024 Authors: Kumar S; Del Moral-Snchez I; Singh S; Newby ML; Allen JD; Bijl TPL; Vaghani Y; Jing L; Ortlund EA; Crispin M
Structure, function, and lipid sensing activity in the thioesterase superfamily.
Biochem Soc Trans Volume: 52 Page(s): 1565 - 1577
08/28/2024 Authors: Little M; Ortlund EA
Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).
Function (Oxf) Volume: 5
07/11/2024 Authors: Schenk S; Sagendorf TJ; Many GM; Lira AK; de Sousa LGO; Bae D; Cicha M; Kramer KS; Muehlbauer M; Hevener AL
The impact of exercise on gene regulation in association with complex trait genetics.
Nat Commun Volume: 15 Page(s): 3346
05/01/2024 Authors: Vetr NG; Gay NR; MoTrPAC Study Group; Montgomery SB
Temporal dynamics of the multi-omic response to endurance exercise training.
Nature Volume: 629 Page(s): 174 - 183
05/01/2024 Authors: MoTrPACStudy Group; Lead Analysts; MoTrPAC Study Group
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
Nat Metab Volume: 6 Page(s): 963 - 979
05/01/2024 Authors: Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock KL; Amar D; Caputo T; Gay NR; Gaul DA
Lipidome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys with Metabolic Dysfunction-Associated Steatotic Liver Disease.
Metabolites Volume: 14
03/28/2024 Authors: Huneault HE; Chen C-Y; Cohen CC; Liu X; Jarrell ZR; He Z; DeSantos KE; Welsh JA; Maner-Smith KM; Ortlund EA
Integrative brain omics approach reveals key role for sn-1 lysophosphatidylethanolamine in Alzheimer's dementia.

02/27/2024 Authors: Ortlund E; Chen C-Y; Maner-Smith K; Khadka M; Ahn J; Gulbin X; Ivanova A; Dammer E; Seyfried N; Bennett D
FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells.
PLoS One Volume: 19 Page(s): e0300168
01/01/2024 Authors: Soto-Avellaneda A; Oxford AE; Halla F; Vasquez P; Oe E; Pugel AD; Schoenfeld AM; Tillman MC; Cuevas A; Ortlund EA
High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.
Mol Metab Volume: 78 Page(s): 101832
12/01/2023 Authors: Krumm CS; Landzberg RS; Ramos-Espiritu L; Adura C; Liu X; Acuna M; Xie Y; Xu X; Tillman MC; Li Y
Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.
Mol Cell Endocrinol Volume: 578 Page(s): 112068
12/01/2023 Authors: Proffitt MR; Liu X; Ortlund EA; Smith GT
Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against Wuhan-WT, delta and omicron BA1, BA2 spike trimers.
iScience Volume: 26 Page(s): 108256
11/17/2023 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; O'Sick WH; Cheedarla S; Baugh TJ; Damhorst GL
Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants.
J Clin Microbiol Volume: 61 Page(s): e0013823
10/24/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.
Protein Sci Volume: 32 Page(s): e4754
10/01/2023 Authors: Mays SG; Hercules D; Ortlund EA; Okafor CD
Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron.
Cell Rep Volume: 42 Page(s): 113150
09/26/2023 Authors: Patel A; Kumar S; Lai L; Keen M; Valanparambil R; Chakravarthy C; Laughlin Z; Frank F; Cheedarla N; Verkerke HP
Correction to 'DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining'.
Nucleic Acids Res Volume: 51 Page(s): 9507
09/22/2023
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.
Nucleic Acids Res Volume: 51 Page(s): 7972 - 7987
08/25/2023 Authors: Head PE; Kapoor-Vazirani P; Nagaraju GP; Zhang H; Rath SK; Luong NC; Haji-Seyed-Javadi R; Sesay F; Wang S-Y; Duong DM
Comparison of activity, structure, and dynamics of SF-1 and LRH-1 complexed with small molecule modulators.
J Biol Chem Volume: 299 Page(s): 104921
08/01/2023 Authors: Cato ML; D'Agostino EH; Spurlin RM; Flynn AR; Cornelison JL; Johnson AM; Fujita RA; Abraham SM; Jui NT; Ortlund EA
Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.
Structure Volume: 31 Page(s): 801 - 811.e5
07/06/2023 Authors: Patel A; Kumar S; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Bajpai P; Raju DR; Edara VV
Meet the authors: Dr. Eva Huber, Dr. Michael Groll, and Dr. Eric Ortlund.
Structure Volume: 31 Page(s): 762 - 763
07/06/2023 Authors: Huber E; Groll M; Ortlund E
Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis.
Cancer Lett Volume: 565 Page(s): 216210
07/01/2023 Authors: He H; Sugiyama A; Snyder NW; Teneche MG; Liu X; Maner-Smith KM; Goessling W; Hagen SJ; Ortlund EA; Najafi-Shoushtari SH
Ligand dependent interaction between PC-TP and PPAR mitigates diet-induced hepatic steatosis in male mice.
Nat Commun Volume: 14 Page(s): 2748
05/12/2023 Authors: Druzak SA; Tardelli M; Mays SG; El Bejjani M; Mo X; Maner-Smith KM; Bowen T; Cato ML; Tillman MC; Sugiyama A
APOE expression and secretion are modulated by mitochondrial dysfunction.
Elife Volume: 12
05/12/2023 Authors: Wynne ME; Ogunbona O; Lane AR; Gokhale A; Zlatic SA; Xu C; Wen Z; Duong DM; Rayaprolu S; Ivanova A
Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
Nat Commun Volume: 14 Page(s): 1638
04/04/2023 Authors: Druzak S; Iffrig E; Roberts BR; Zhang T; Fibben KS; Sakurai Y; Verkerke HP; Rostad CA; Chahroudi A; Schneider F
Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants.
medRxiv
02/10/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
bioRxiv
02/04/2023 Authors: Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock K; Amar D; Caputo T; Gay NR; Gaul DA
The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.
bioRxiv
01/28/2023 Authors: Mays SG; Hercules D; Ortlund EA; Okafor CD
African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids.
Nutrients Volume: 15
12/28/2022 Authors: Maner-Smith KM; Ferranti E; Dunlop A; Corwin E; Ortlund EA
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.
Nat Commun Volume: 13 Page(s): 6707
11/07/2022 Authors: Kapoor-Vazirani P; Rath SK; Liu X; Shu Z; Bowen NE; Chen Y; Haji-Seyed-Javadi R; Daddacha W; Minten EV; Danelia D
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
Nature Volume: 611 Page(s): 769 - 779
11/01/2022 Authors: Blanchard JW; Akay LA; Davila-Velderrain J; von Maydell D; Mathys H; Davidson SM; Effenberger A; Chen C-Y; Maner-Smith K; Hajjar I
Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.
bioRxiv
10/24/2022 Authors: Patel A; Kumar S; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Bajpai P; Raju DR; Edara VV
Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody.
Sci Adv Volume: 8 Page(s): eadd2032
10/07/2022 Authors: Kumar S; Patel A; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Davis-Gardner ME; Edara VV; Linderman S
OBESITY-INDUCED ACTIVATION OF Ybx1 PROMOTES ADIPOGENIC AND INFLAMMATORY GENE EXPRESSION WITHIN HEPATOCYTES
Volume: 76 Page(s): S831 - S831
10/01/2022 Authors: Jordan JM; Qiao J; Haczeyni F; Maner-Smith KM; Ortlund EA; Ersoy BA
COMBINED VIRTUAL AND CHEMICAL HIGH-THROUGHPUT SCREENING IDENTIFIES SMALL MOLECULE INHIBITORS TARGETING THIOESTERASE SUPERFAMILY MEMBER 2 FOR THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
Volume: 76 Page(s): S660 - S661
10/01/2022 Authors: Landzberg RS; Krumm CS; Hare SR; Liu X; Ortlund EA; Cohen DE
CATALYTIC ACTIVITY IS REQUIRED FOR THIOESTERASE SUPERFAMILY MEMBER 2 IN SKELETAL MUSCLE TO PROMOTE HEPATIC STEATOSIS AND INSULIN RESISTANCE
Volume: 76 Page(s): S643 - S643
10/01/2022 Authors: Xie Y; Liu X; Ortlund EA; Cohen DE
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.
Cell Volume: 185 Page(s): 3603 - 3616.e13
09/15/2022 Authors: Frank F; Keen MM; Rao A; Bassit L; Liu X; Bowers HB; Patel AB; Cato ML; Sullivan JA; Greenleaf M
A phospholipid mimetic targeting LRH-1 ameliorates colitis.
Cell Chem Biol Volume: 29 Page(s): 1174 - 1186.e7
07/21/2022 Authors: Mays SG; D'Agostino EH; Flynn AR; Huang X; Wang G; Liu X; Millings EJ; Okafor CD; Patel A; Cato ML
Lysosome lipid signalling from the periphery to neurons regulates longevity.
Nat Cell Biol Volume: 24 Page(s): 906 - 916
06/01/2022 Authors: Savini M; Folick A; Lee Y-T; Jin F; Cuevas A; Tillman MC; Duffy JD; Zhao Q; Neve IA; Hu P-W
Don't forget about human factors: Lessons learned from COVID-19 point-of-care testing.
Cell Rep Methods Volume: 2 Page(s): 100222
05/23/2022 Authors: Farmer S; Razin V; Peagler AF; Strickler S; Fain WB; Damhorst GL; Kempker RR; Pollock NR; Brand O; Seitter B
Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.
J Med Chem Volume: 65 Page(s): 6888 - 6902
05/12/2022 Authors: Cato ML; Cornelison JL; Spurlin RM; Courouble VV; Patel AB; Flynn AR; Johnson AM; Okafor CD; Frank F; D'Agostino EH
Development and Characterization of Novel LRH-1 Antagonist Using Structural and Computational Techniques.
FASEB J Volume: 36 Suppl 1
05/01/2022 Authors: Cato ML; Spurlin R; Cornelison J; Jui N; Ortlund E
Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against native-like vaccine and delta variant spike trimers.
Res Sq
02/16/2022 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; Damhorst GL; Wu H; O'Sick WH; Graciaa D
Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against native-like vaccine and delta variant spike trimers.
medRxiv
02/02/2022 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; Damhorst GL; Wu H; O Sick WH; Graciaa D
Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity.
PLoS One Volume: 17 Page(s): e0277053
01/01/2022 Authors: Heintz MM; Eccles JA; Olack EM; Maner-Smith KM; Ortlund EA; Baldwin WS
Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice.
Hepatology Volume: 75 Page(s): 154 - 169
01/01/2022 Authors: Imai N; Nicholls HT; Alves-Bezerra M; Li Y; Ivanova AA; Ortlund EA; Cohen DE
Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice.
J Lipids Volume: 2022 Page(s): 7122738
01/01/2022 Authors: Heintz MM; Kumar R; Maner-Smith KM; Ortlund EA; Baldwin WS
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.
Nat Metab Volume: 3 Page(s): 1694 - 1705
12/01/2021 Authors: Liu KH; Owens JA; Saeedi B; Cohen CE; Bellissimo MP; Naudin C; Darby T; Druzak S; Maner-Smith K; Orr M
Structural insights into glucocorticoid receptor function.
Biochem Soc Trans Volume: 49 Page(s): 2333 - 2343
11/01/2021 Authors: Frank F; Ortlund EA; Liu X
Disruption of a key ligand-H-bond network drives glucocorticoid receptor gene suppression without off-target gene activation
Volume: 30 Page(s): 23 - 23
10/01/2021 Authors: Liu X; Hoffman E; Ortlund E
Ligand-dependent interactions between phosphatidylcholine transfer protein and PPARd: Therapeutic implications for the metabolic syndrome.
Volume: 30 Page(s): 71 - 72
10/01/2021 Authors: Druzak S; Tardelli M; Mays S; Cato M; Tillman M; Cohen D; Ortlund E
Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element.
Nucleic Acids Res Volume: 49 Page(s): 8923 - 8933
09/07/2021 Authors: Liu X; Weikum ER; Tilo D; Vinson C; Ortlund EA
TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis.
PLoS Pathog Volume: 17 Page(s): e1009941
09/01/2021 Authors: Collins JM; Jones DP; Sharma A; Khadka M; Liu KH; Kempker RR; Prideaux B; Maner-Smith K; Tukvadze N; Shah NS
Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation.
Proc Natl Acad Sci U S A Volume: 118
07/27/2021 Authors: Frank F; Liu X; Ortlund EA
Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.
Nat Commun Volume: 12 Page(s): 3493
06/09/2021 Authors: Li Y; Imai N; Nicholls HT; Roberts BR; Goyal S; Krisko TI; Ang L-H; Tillman MC; Roberts AM; Baqai M
Targeting Them1 for the Management of Obesity-Related Disorders
Volume: 35
05/01/2021 Authors: Krumm C; Ramos-Espiritu L; Adura C; Tillman M; Landzberg R; Glickman JF; Ortlund E; Cohen D
Uniting features from strongly activating small molecules to develop chimeric LRH-1 agonist
Volume: 35
05/01/2021 Authors: Cato M; Cornelison J; Flynn A; Johnson A; Okafor C; Jui N; Patel A; Frank F; D'Agostino E; Ortlund E
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.
Nat Chem Biol Volume: 17 Page(s): 307 - 316
03/01/2021 Authors: Bruno NE; Nwachukwu JC; Srinivasan S; Nettles CC; Izard T; Jin Z; Nowak J; Cameron MD; Boregowda SV; Phinney DG
RADx Variant Task Force Program for Assessing the Impact of Variants on SARS-CoV-2 Molecular and Antigen Tests.
IEEE Open J Eng Med Biol Volume: 2 Page(s): 286 - 290
01/01/2021 Authors: Creager R; Blackwood J; Pribyl T; Bassit L; Rao A; Greenleaf M; Frank F; Lam W; Ortlund E; Schinazi R
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.
J Biol Chem Volume: 296 Page(s): 100024
01/01/2021 Authors: Squires KE; Gerber KJ; Tillman MC; Lustberg DJ; Montaez-Miranda C; Zhao M; Ramineni S; Scharer CD; Saha RN; Shu F-J
Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist.
Sci Rep Volume: 10 Page(s): 22279
12/17/2020 Authors: Mays SG; Stec J; Liu X; D'Agostino EH; Whitby RJ; Ortlund EA
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.
J Biol Chem
11/04/2020 Authors: Squires KE; Gerber KJ; Tillman MC; Lustberg DJ; Montaez-Miranda C; Zhao M; Ramineni S; Scharer CD; Saha RN; Shu F-J
The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
Nat Commun Volume: 11 Page(s): 5010
10/06/2020 Authors: Moody JC; Qadota H; Reedy AR; Okafor CD; Shanmugan N; Matsunaga Y; Christian CJ; Ortlund EA; Benian GM
Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.
Proc Natl Acad Sci U S A Volume: 117 Page(s): 24285 - 24293
09/29/2020 Authors: Liu X; Wang Y; Gutierrez JS; Damsker JM; Nagaraju K; Hoffman EP; Ortlund EA
Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine.
Proc Natl Acad Sci U S A Volume: 117 Page(s): 22080 - 22089
09/08/2020 Authors: Tillman MC; Imai N; Li Y; Khadka M; Okafor CD; Juneja P; Adhiyaman A; Hagen SJ; Cohen DE; Ortlund EA
A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.
Proc Natl Acad Sci U S A Volume: 117 Page(s): 21673 - 21680
09/01/2020 Authors: Merritt JR; Grogan KE; Zinzow-Kramer WM; Sun D; Ortlund EA; Yi SV; Maney DL
Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver.
Hepatology Volume: 72 Page(s): 857 - 872
09/01/2020 Authors: Steensels S; Qiao J; Zhang Y; Maner-Smith KM; Kika N; Holman CD; Corey KE; Bracken WC; Ortlund EA; Ersoy BA
Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition.
Bioorg Med Chem Lett Volume: 30 Page(s): 127293
08/15/2020 Authors: Cornelison JL; Cato ML; Johnson AM; D'Agostino EH; Melchers D; Patel AB; Mays SG; Houtman R; Ortlund EA; Jui NT
Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet.
Gastroenterology Volume: 159 Page(s): 639 - 651.e5
08/01/2020 Authors: Naudin CR; Maner-Smith K; Owens JA; Wynn GM; Robinson BS; Matthews JD; Reedy AR; Luo L; Wolfarth AA; Darby TM
Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination.
Vaccines (Basel) Volume: 8
07/24/2020 Authors: Maner-Smith KM; Goll JB; Khadka M; Jensen TL; Colucci JK; Gelber CE; Albert CJ; Bosinger SE; Franke JD; Natrajan M
The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions.
Cell Rep Volume: 32 Page(s): 107933
07/21/2020 Authors: Frank F; Kavousi N; Bountali A; Dammer EB; Mourtada-Maarabouni M; Ortlund EA
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.
Cell Volume: 181 Page(s): 1464 - 1474
06/25/2020 Authors: Sanford JA; Nogiec CD; Lindholm ME; Adkins JN; Amar D; Dasari S; Drugan JK; Fernndez FM; Radom-Aizik S; Schenk S
Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients.
Cell Rep Med Volume: 1 Page(s): 100040
06/23/2020 Authors: Suthar MS; Zimmerman MG; Kauffman RC; Mantus G; Linderman SL; Hudson WH; Vanderheiden A; Nyhoff L; Davis CW; Adekunle O
Rapid generation of neutralizing antibody responses in COVID-19 patients.
medRxiv
05/08/2020 Authors: Suthar MS; Zimmerman M; Kauffman R; Mantus G; Linderman S; Vanderheiden A; Nyhoff L; Davis C; Adekunle S; Affer M
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise.
Science Volume: 368
05/01/2020 Authors: Knudsen NH; Stanya KJ; Hyde AL; Chalom MM; Alexander RK; Liou Y-H; Starost KA; Gangl MR; Jacobi D; Liu S
Them1 Binds to Free Fatty Acids and is Allosterically Regulated by Lysophosphatidylcholine to Control Fatty Acyl-CoA Hydrolysis in Brown Adipose Tissue
Volume: 34
04/01/2020 Authors: Tillman M; Li Y; Khadka M; Imai N; Adhiyaman A; Juneja P; Hagen S; Cohen D; Ortlund E
The Them1 START Domain Regulates Nuclear Trafficking in Brown Adipocytes
Volume: 34
04/01/2020 Authors: Baqai M; Li Y; Tillman M; Ortlund E; Cohen D; Hagen S
Fragment-Based Screening to Identify Thioesterase Superfamily Member 2 (Them2) Inhibitors for the Management of Obesity-Related Disorders
Volume: 34
04/01/2020 Authors: Krumm C; Adura C; Liu X; Li Y; Bracken W; Ginn J; Glickman J; Ortlund E; Cohen D
Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolic Activity in Brown Adipose Tissue
Volume: 34
04/01/2020 Authors: Li Y; Imai N; Goyal S; Nicholls H; Krisko T; Baqai M; Ang L-H; Tillman M; Ortlund E; Cohen D
Development of picomolar liver receptor homolog-1 agonist
Volume: 34
04/01/2020 Authors: Cato M; Cornelison J; Flynn A; D'Agostino E; Jui N; Ortlund E
Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.
ACS Med Chem Lett Volume: 11 Page(s): 365 - 370
03/12/2020 Authors: D'Agostino EH; Flynn AR; Cornelison JL; Mays SG; Patel A; Jui NT; Ortlund EA
Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors.
Structure Volume: 28 Page(s): 196 - 205.e3
02/04/2020 Authors: Okafor CD; Hercules D; Kell SA; Ortlund EA
Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
Cell Mol Gastroenterol Hepatol Volume: 10 Page(s): 713 - 727
01/01/2020 Authors: Wolfarth AA; Liu X; Darby TM; Boyer DJ; Spizman JB; Owens JA; Chandrasekharan B; Naudin CR; Hanley KZ; Robinson BS
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
J Med Chem Volume: 62 Page(s): 11022 - 11034
12/26/2019 Authors: Mays SG; Flynn AR; Cornelison JL; Okafor CD; Wang H; Wang G; Huang X; Donaldson HN; Millings EJ; Polavarapu R
First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-Activated Coactivator 1- Complex with Endogenous and Synthetic Glucocorticoids.
Mol Pharmacol Volume: 96 Page(s): 408 - 417
10/01/2019 Authors: Liu X; Wang Y; Ortlund EA
Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis.
Hepatology Volume: 70 Page(s): 496 - 510
08/01/2019 Authors: Alves-Bezerra M; Li Y; Acua M; Ivanova AA; Corey KE; Ortlund EA; Cohen DE
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8.
Sci Rep Volume: 9 Page(s): 9966
07/10/2019 Authors: Tillman MC; Khadka M; Duffy J; Wang MC; Ortlund EA
The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry.
Biomolecules Volume: 9
05/23/2019 Authors: Khadka M; Todor A; Maner-Smith KM; Colucci JK; Tran V; Gaul DA; Anderson EJ; Natrajan MS; Rouphael N; Mulligan MJ
Distinct amino acid and lipid perturbations characterize acute versus chronic malaria.
JCI Insight Volume: 4
05/02/2019 Authors: Cordy RJ; Patrapuvich R; Lili LN; Cabrera-Mora M; Chien J-T; Tharp GK; Khadka M; Meyer EV; Lapp SA; Joyner CJ
Development of a Robust Direct Binding Assay for Phospholipid-Sensing NR5A Receptors
Volume: 33
04/01/2019 Authors: D'Agostino EH; Cornelison J; Mays S; Flynn A; Jui N; Ortlund E
Fatty Acids Bind to Theml, a Negative Regulator of Thermogenesis in Brown Adipose Tissue
Volume: 33
04/01/2019 Authors: Tillman MC; Khadka M; Okafor CD; Juneja PC; Ortlund EA
The Allosteric Mechanisms Driving the Evolution of Androgen Specificity
Volume: 27 Page(s): 148 - 148
11/01/2018 Authors: Okafor D; Colucci J; Ortlund E
Structure and Inhibition of Them2, An Acyl-Coa Thioesterase that Controls Hepatic Glucose and Lipid Metabolism
Volume: 27 Page(s): 188 - 189
11/01/2018 Authors: Liu X; Tillander V; Cohen D; Ortlund E
The nuclear receptor superfamily: A structural perspective.
Protein Sci Volume: 27 Page(s): 1876 - 1892
11/01/2018 Authors: Weikum ER; Liu X; Ortlund EA
Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1.
ACS Med Chem Lett Volume: 9 Page(s): 1051 - 1056
10/11/2018 Authors: Flynn AR; Mays SG; Ortlund EA; Jui NT
Delimiting the autoinhibitory module of von Willebrand factor.
J Thromb Haemost Volume: 16 Page(s): 2097 - 2105
10/01/2018 Authors: Deng W; Voos KM; Colucci JK; Legan ER; Ortlund EA; Lollar P; Li R
The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor.
Sci Rep Volume: 8 Page(s): 13497
09/10/2018 Authors: Frank F; Okafor CD; Ortlund EA
The allosteric mechanisms driving the evolution of androgen specificity
Volume: 256
08/19/2018 Authors: Okafor C; Colucci J; Ortlund E
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Immunity Volume: 49 Page(s): 42 - 55.e6
07/17/2018 Authors: Mandal P; Feng Y; Lyons JD; Berger SB; Otani S; DeLaney A; Tharp GK; Maner-Smith K; Burd EM; Schaeffer M
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-B response elements.
Nat Commun Volume: 9 Page(s): 1337
04/06/2018 Authors: Hudson WH; Vera IMSD; Nwachukwu JC; Weikum ER; Herbst AG; Yang Q; Bain DL; Nettles KW; Kojetin DJ; Ortlund EA
Fatty Acids Bind to the StAR-Related Lipid Transfer Domain of Thioesterase Superfamily Member 1, a Master Regulator of Thermogenesis and Energy Expenditure
Volume: 32
04/01/2018 Authors: Tillman MC; Ortlund E
Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
Structure Volume: 26 Page(s): 118 - 129.e3
01/02/2018 Authors: Okafor CD; Pathak MC; Fagan CE; Bauer NC; Cole MF; Gaucher EA; Ortlund EA
High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans.
PLoS One Volume: 13 Page(s): e0205398
01/01/2018 Authors: Collins JM; Walker DI; Jones DP; Tukvadze N; Liu KH; Tran VT; Uppal K; Frediani JK; Easley KA; Shenvi N
Elucidating the Mechanism of Lipid Binding Protein 8 Shuttling of Lysosomal Lipids into the Nucleus in Caenorhabditis Elegans
Volume: 26 Page(s): 185 - 185
12/01/2017 Authors: Tillman M; Wang M; Ortlund E
Nucleotide Binding to ARL2 in the TBCDARL2-Tubulin Complex Drives Conformational Changes in -Tubulin.
J Mol Biol Volume: 429 Page(s): 3696 - 3716
11/24/2017 Authors: Francis JW; Goswami D; Novick SJ; Pascal BD; Weikum ER; Ortlund EA; Griffin PR; Kahn RA
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic Acids Res Volume: 45 Page(s): 8596 - 8608
08/21/2017 Authors: Weikum ER; de Vera IMS; Nwachukwu JC; Hudson WH; Nettles KW; Kojetin DJ; Ortlund EA
Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.
Mol Pharmacol Volume: 92 Page(s): 12 - 21
07/01/2017 Authors: Weikum ER; Okafor CD; D'Agostino EH; Colucci JK; Ortlund EA
Structure and Dynamics of the Liver Receptor Homolog 1-PGC1 Complex.
Mol Pharmacol Volume: 92 Page(s): 1 - 11
07/01/2017 Authors: Mays SG; Okafor CD; Tuntland ML; Whitby RJ; Dharmarajan V; Stec J; Griffin PR; Ortlund EA
Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation
Volume: 31
04/01/2017 Authors: Okafor D; Mays SC; Whitby RJ; Goswami D; Stec J; Flynn AR; Dugan MC; Jui N; Griffin P; Ortlund E
An estrogen receptor alpha polymorphism may mediate behavioral polymorphism in the white-throated sparrow
Volume: 57 Page(s): E348 - E348
03/01/2017 Authors: Merritt JR; Mays SG; Ortlund EA; Maney DL
Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
Nat Rev Mol Cell Biol Volume: 18 Page(s): 159 - 174
03/01/2017 Authors: Weikum ER; Knuesel MT; Ortlund EA; Yamamoto KR
THE ROLE OF SOLUBLE LIPID TRANSPORT PROTEINS IN MODULATING LIVER RECEPTOR HOMOLOG-1 (LRH-1) MEDIATED GENE EXPRESSION
Volume: 88 Page(s): 34 - 35
01/01/2017 Authors: El Bejjani M; Mays SG; Tillman MC; Ortlund EA
Elucidating the Mechanism of LBP-8 Shuttling of Lysosomal Lipids into the Nucleus in C. elegans
Volume: 73 Page(s): A106 - A106
01/01/2017 Authors: Tillman M; Wang M; Ortlund E
Targeting the Nuclear Receptor LRH-1 with Synthetic Agonists
Volume: 73 Page(s): A98 - A98
01/01/2017 Authors: Mays SG; Okafor CD; Whitby R; Goswami D; Stec J; Flynn A; Dugan M; Jui N; Griffin P; Ortlund EA
A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).
J Mol Biol Volume: 428 Page(s): 4981 - 4992
12/04/2016 Authors: Weikum ER; Tuntland ML; Murphy MN; Ortlund EA
Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
J Biol Chem Volume: 291 Page(s): 25281 - 25291
12/02/2016 Authors: Mays SG; Okafor CD; Whitby RJ; Goswami D; Stec J; Flynn AR; Dugan MC; Jui NT; Griffin PR; Ortlund EA
Biophysical mechanisms driving the evolution of androgen specificity
Volume: 25 Page(s): 100 - 100
10/01/2016 Authors: Okafor D; Colucci J; Ortlund E
Untethering glucocorticoid receptor-mediated transcriptional repression
Volume: 30
04/01/2016 Authors: Weikum ER; Hudson W; Ortlund E
Untethering glucocorticoid receptor-mediated transcriptional repression
Volume: 30
04/01/2016 Authors: Weikum ER; Hudson W; Ortlund E
Computational discovery of activating and repressing states for the liver receptor homologue 1 ligand binding domain
Volume: 251
03/13/2016 Authors: Kossmann B; Musille P; Ivanov I; Ortlund E
Evolving allostery of the 3-ketosteroid family of nuclear receptors
Volume: 251
03/13/2016 Authors: Kossmann B; Hudson W; Ivanov I; Ortlund E
Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.
J Biol Chem Volume: 291 Page(s): 1411 - 1426
01/15/2016 Authors: Musille PM; Kossmann BR; Kohn JA; Ivanov I; Ortlund EA
Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc Natl Acad Sci U S A Volume: 113 Page(s): 326 - 331
01/12/2016 Authors: Hudson WH; Kossmann BR; de Vera IMS; Chuo S-W; Weikum ER; Eick GN; Thornton JW; Ivanov IN; Kojetin DJ; Ortlund EA
Identification of a lipid scrambling domain in ANO6/TMEM16F.
Elife Volume: 4 Page(s): e06901
06/09/2015 Authors: Yu K; Whitlock JM; Lee K; Ortlund EA; Cui YY; Hartzell HC
Integration of G protein (G) signaling by the regulator of G protein signaling 14 (RGS14).
J Biol Chem Volume: 290 Page(s): 9037 - 9049
04/03/2015 Authors: Brown NE; Goswami D; Branch MR; Ramineni S; Ortlund EA; Griffin PR; Hepler JR
An Allosteric Network in LRH-1 Mediates Phospholipid-Driven Gene Regulation
Volume: 29
04/01/2015 Authors: Kohn J; Musille P; Kossmann B; Ivanov I; Ortlund E
Evolution of Novel Response Element Specificity in the Glucocorticoid Receptor
Volume: 29
04/01/2015 Authors: Hudson W; Ortlund E
Untethering Glucocorticoid Receptor-Mediated Transcriptional Repression of Inflammatory Genes
Volume: 29
04/01/2015 Authors: Rye E; Ortlund E
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
Science Volume: 347 Page(s): 83 - 86
01/02/2015 Authors: Folick A; Oakley HD; Yu Y; Armstrong EH; Kumari M; Sanor L; Moore DD; Ortlund EA; Zechner R; Wang MC
Evolution of novel response element specificity in the glucocorticoid receptor
Volume: 25
12/01/2014 Authors: Hudson WH; Ortlund EA
Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun Volume: 5 Page(s): 5395
11/07/2014 Authors: Hudson WH; Pickard MR; de Vera IMS; Kuiper EG; Mourtada-Maarabouni M; Conn GL; Kojetin DJ; Williams GT; Ortlund EA
The structure, function and evolution of proteins that bind DNA and RNA.
Nat Rev Mol Cell Biol Volume: 15 Page(s): 749 - 760
11/01/2014 Authors: Hudson WH; Ortlund EA
Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell Volume: 159 Page(s): 58 - 68
09/25/2014 Authors: McKeown AN; Bridgham JT; Anderson DW; Murphy MN; Ortlund EA; Thornton JW
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor / (FABP5-PPAR/) signaling pathway.
J Biol Chem Volume: 289 Page(s): 14941 - 14954
05/23/2014 Authors: Armstrong EH; Goswami D; Griffin PR; Noy N; Ortlund EA
Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.
Diabetes Volume: 63 Page(s): 1394 - 1409
04/01/2014 Authors: Qiang G; Xue S; Yang JJ; Du G; Pang X; Li X; Goswami D; Griffin PR; Ortlund EA; Chan CB
Evolutionary history and metabolic insights of ancient mammalian uricases.
Proc Natl Acad Sci U S A Volume: 111 Page(s): 3763 - 3768
03/11/2014 Authors: Kratzer JT; Lanaspa MA; Murphy MN; Cicerchi C; Graves CL; Tipton PA; Ortlund EA; Johnson RJ; Gaucher EA
A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis.
Mol Biol Cell Volume: 25 Page(s): 712 - 727
03/01/2014 Authors: Ren J; Pei-Chen Lin C; Pathak MC; Temple BRS; Nile AH; Mousley CJ; Duncan MC; Eckert DM; Leiker TJ; Ivanova PT
Structure of glycerol dehydrogenase from Serratia.
Acta Crystallogr F Struct Biol Commun Volume: 70 Page(s): 166 - 172
02/01/2014 Authors: Musille P; Ortlund E
Estrogen receptor polymorphism in a species with alternative behavioral phenotypes.
Proc Natl Acad Sci U S A Volume: 111 Page(s): 1443 - 1448
01/28/2014 Authors: Horton BM; Hudson WH; Ortlund EA; Shirk S; Thomas JW; Young ER; Zinzow-Kramer WM; Maney DL
Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.
PLoS Genet Volume: 10 Page(s): e1004058
01/01/2014 Authors: Bridgham JT; Keay J; Ortlund EA; Thornton JW
Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
PLoS One Volume: 9 Page(s): e107000
01/01/2014 Authors: Hudson WH; Youn C; Ortlund EA
Expression, purification and crystallization of the ancestral androgen receptor-DHT complex.
Acta Crystallogr Sect F Struct Biol Cryst Commun Volume: 69 Page(s): 994 - 996
09/01/2013 Authors: Colucci JK; Ortlund EA
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors.
J Biol Chem Volume: 288 Page(s): 20702 - 20712
07/12/2013 Authors: Musille PM; Pathak M; Lauer JL; Griffin PR; Ortlund EA
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 11475 - 11480
07/09/2013 Authors: Harms MJ; Eick GN; Goswami D; Colucci JK; Griffin PR; Ortlund EA; Thornton JW
Phospholipid--driven gene regulation.
FEBS Lett Volume: 587 Page(s): 1238 - 1246
04/17/2013 Authors: Musille PM; Kohn JA; Ortlund EA
Hydrophobic environment is a key factor for the stability of thermophilic proteins.
Proteins Volume: 81 Page(s): 715 - 721
04/01/2013 Authors: Gromiha MM; Pathak MC; Saraboji K; Ortlund EA; Gaucher EA
The structural basis of direct glucocorticoid-mediated transrepression.
Nat Struct Mol Biol Volume: 20 Page(s): 53 - 58
01/01/2013 Authors: Hudson WH; Youn C; Ortlund EA
X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface.
PLoS One Volume: 8 Page(s): e80761
01/01/2013 Authors: Colucci JK; Ortlund EA
Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation.
ChemMedChem Volume: 7 Page(s): 1909 - 1914
11/01/2012 Authors: Rey J; Hu H; Kyle F; Lai C-F; Buluwela L; Coombes RC; Ortlund EA; Ali S; Snyder JP; Barrett AGM
Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors
Volume: 21 Page(s): 168 - 168
08/01/2012 Authors: Kohn J; Deshpande K; Ortlund E
Evolution of Ligand Specificity in Steroid Hormone Nuclear Receptors
Volume: 21 Page(s): 87 - 87
08/01/2012 Authors: Colucci J; Ortlund E
Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors.
J Biol Chem Volume: 287 Page(s): 16267 - 16275
05/11/2012 Authors: Kohn JA; Deshpande K; Ortlund EA
Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat Struct Mol Biol Volume: 19 Page(s): 532 - 5S2
04/15/2012 Authors: Musille PM; Pathak M; Lauer JL; Hudson WH; Griffin PR; Ortlund EA
Evolution of minimal specificity and promiscuity in steroid hormone receptors.
PLoS Genet Volume: 8 Page(s): e1003072
01/01/2012 Authors: Eick GN; Colucci JK; Harms MJ; Ortlund EA; Thornton JW
Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily.
Acta Crystallogr Sect F Struct Biol Cryst Commun Volume: 67 Page(s): 1239 - 1243
10/01/2011 Authors: Ren J; Schaaf G; Bankaitis VA; Ortlund EA; Pathak MC
The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells.
Breast Cancer Res Treat Volume: 127 Page(s): 385 - 396
06/01/2011 Authors: Thiruchelvam PTR; Lai C-F; Hua H; Thomas RS; Hurtado A; Hudson W; Bayly AR; Kyle FJ; Periyasamy M; Photiou A
Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.
PLoS Genet Volume: 7 Page(s): e1002117
06/01/2011 Authors: Carroll SM; Ortlund EA; Thornton JW
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.
Nature Volume: 474 Page(s): 506 - 510
05/25/2011 Authors: Lee JM; Lee YK; Mamrosh JL; Busby SA; Griffin PR; Pathak MC; Ortlund EA; Moore DD
Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution.
Mol Biol Cell Volume: 22 Page(s): 892 - 905
03/15/2011 Authors: Schaaf G; Dynowski M; Mousley CJ; Shah SD; Yuan P; Winklbauer EM; de Campos MKF; Trettin K; Quinones M-C; Smirnova TI
Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.
PLoS Biol Volume: 8
10/05/2010 Authors: Bridgham JT; Eick GN; Larroux C; Deshpande K; Harms MJ; Gauthier MEA; Ortlund EA; Degnan BM; Thornton JW
Molecular Evolution of Mineralocorticoid Receptor - Hormone Interactions
Volume: 50 Page(s): E17 - E17
07/01/2010 Authors: Bridgham JT; Ortlund EA; Thornton JW
Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection.
Proc Natl Acad Sci U S A Volume: 107 Page(s): 1948 - 1953
02/02/2010 Authors: Chen F; Gaucher EA; Leal NA; Hutter D; Havemann SA; Govindarajan S; Ortlund EA; Benner SA
An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.
Nature Volume: 461 Page(s): 515 - 519
09/24/2009 Authors: Bridgham JT; Ortlund EA; Thornton JW
Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily.
Mol Cell Volume: 29 Page(s): 191 - 206
02/01/2008 Authors: Schaaf G; Ortlund EA; Tyeryar KR; Mousley CJ; Ile KE; Garrett TA; Ren J; Woolls MJ; Raetz CRH; Redinbo MR
Crystal structure of an ancient protein: evolution by conformational epistasis.
Science Volume: 317 Page(s): 1544 - 1548
09/14/2007 Authors: Ortlund EA; Bridgham JT; Redinbo MR; Thornton JW
Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.
Biochim Biophys Acta Volume: 1774 Page(s): 637 - 644
05/01/2007 Authors: Chiswell B; Lovelace LL; Brannen C; Ortlund EA; Lebioda L; Sodetz JM
Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
J Mol Biol Volume: 354 Page(s): 1091 - 1102
12/16/2005 Authors: Solomon IH; Hager JM; Safi R; McDonnell DP; Redinbo MR; Ortlund EA
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
Nat Struct Mol Biol Volume: 12 Page(s): 357 - 363
04/01/2005 Authors: Ortlund EA; Lee Y; Solomon IH; Hager JM; Safi R; Choi Y; Guan Z; Tripathy A; Raetz CRH; McDonnell DP
Crystal structure of a covalent intermediate of endogenous human arylsulfatase A.
J Inorg Biochem Volume: 96 Page(s): 386 - 392
08/01/2003 Authors: Chruszcz M; Laidler P; Monkiewicz M; Ortlund E; Lebioda L; Lewinski K
Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design.
Biochemistry Volume: 42 Page(s): 383 - 389
01/21/2003 Authors: Ortlund E; LaCount MW; Lebioda L
Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.
Biochemistry Volume: 41 Page(s): 7030 - 7037
06/04/2002 Authors: Ortlund E; Parker CL; Schreck SF; Ginell S; Minor W; Sodetz JM; Lebioda L
Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.
Biochemistry Volume: 39 Page(s): 1199 - 1204
02/15/2000 Authors: Ortlund E; Lacount MW; Lewinski K; Lebioda L