Anupam Patgiri
- Department of Pharmacology & Chemical Biology
Assistant Professor
Overview
The Patgiri lab studies how mutations in mitochondrial and other metabolic genes cause devastating neuromuscular disorders to guide potential therapy. Mitochondrial diseases currently have no FDA-approved therapy. Therefore, we are using small molecule and enzyme engineering approaches to reestablish mitochondrial and metabolic homeostasis in cell and animal models of mitochondrial disease. Currently, we are testing the therapeutic potential of (a) correcting biochemical consequences (e.g., redox, bioenergetic) of mutated metabolic genes and (b) selectively eliminating toxic, defective mitochondria in disease. In another project, we are developing strategies to modulate metabolism in the tumor-immune microenvironment to boost the cytotoxicity of immune cells (T cells and macrophages) as anticancer therapeutics. For more information, please visit the Patgiri lab website listed above.
Education
Degrees
- PhD from New York University
- MSc from Indian Institute of Technology Guwahati
- BSc from Gauhati University
Research
Publications
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
11/18/2024 Authors: Lane AR; Scher NE; Bhattacharjee S; Zlatic SA; Roberts AM; Gokhale A; Singleton KS; Duong DM; McKenna M; Liu WL -
Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
Hum Mol Genet Volume: 33 Page(s): 12 - 32
12/12/2023 Authors: Zlatic SA; Werner E; Surapaneni V; Lee CE; Gokhale A; Singleton K; Duong D; Crocker A; Gentile K; Middleton F -
Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants.
bioRxiv
09/01/2023 Authors: Zlatic SA; Werner E; Surapaneni V; Lee CE; Gokhale A; Singleton K; Duong D; Crocker A; Gentile K; Middleton F -
Mitochondrial protein synthesis and the bioenergetic cost of neurodevelopment.
iScience Volume: 25 Page(s): 104920
09/16/2022 Authors: Blow P; Patgiri A; Faundez V -
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
Nucleic Acids Res Volume: 49 Page(s): D1541 - D1547
01/08/2021 Authors: Rath S; Sharma R; Gupta R; Ast T; Chan C; Durham TJ; Goodman RP; Grabarek Z; Haas ME; Hung WHW -
Hepatic NADH reductive stress underlies common variation in metabolic traits.
Nature Volume: 583 Page(s): 122 - 126
07/01/2020 Authors: Goodman RP; Markhard AL; Shah H; Sharma R; Skinner OS; Clish CB; Deik A; Patgiri A; Hsu Y-HH; Masia R -
An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance.
Nat Biotechnol Volume: 38 Page(s): 309 - 313
03/01/2020 Authors: Patgiri A; Skinner OS; Miyazaki Y; Schleifer G; Marutani E; Shah H; Sharma R; Goodman RP; To T-L; Robert Bao X -
Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis.
Cell Volume: 167 Page(s): 512 - 524.e14
10/06/2016 Authors: Kawashima SA; Chen Z; Aoi Y; Patgiri A; Kobayashi Y; Nurse P; Kapoor TM -
The discovery and validation of a potent and selective chemical inhibitor of Midasin, a dynein-like AAA plus ATPase required for ribosome biogenesis.
Volume: 26
01/01/2015 Authors: Chen Z; Kawashima SA; Aoi Y; Patgiri A; Kobayashi Y; Nurse P; Kapoor TM -
Nucleation effects in peptide foldamers.
J Am Chem Soc Volume: 134 Page(s): 11495 - 11502
07/18/2012 Authors: Patgiri A; Joy ST; Arora PS