Publications

• Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology.
  Nat Commun Volume: 16 Page(s): 4222
  05/07/2025 Authors: Xie L; Sheehy RN; Muneer A; Xiong Y; Wrobel JA; Zhang F; Park K-S; Velez J; Liu J; Luo Y-J
• Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology.
  Cancers (Basel) Volume: 17
  02/05/2025 Authors: Zohdy YM; Jahangiri A; Jacob F; Aksionau A; Alawieh AM; Tong A; Chern B; Maldonado J; Hoang K; Nduom E
• Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging.
  Adv Mater Technol Volume: 10
  02/05/2025 Authors: Charles S; Jackson-Holmes E; Sun G; Zhou Y; Siciliano B; Niu W; Han H; Nikitina A; Kemp ML; Wen Z
• Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex.
  bioRxiv
  10/11/2024 Authors: Niu W; Yu S; Li X; Wang Z; Chen R; Michalski C; Jahangiri A; Zohdy Y; Chern JJ; Whitworth TJ
• Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids.
  Sci Rep Volume: 14 Page(s): 22331
  09/27/2024 Authors: Serafini CE; Charles S; Casteleiro Costa P; Niu W; Cheng B; Wen Z; Lu H; Robles FE
• Deep5hmC: predicting genome-wide 5-hydroxymethylcytosine landscape via a multimodal deep learning model.
  Bioinformatics Volume: 40
  09/02/2024 Authors: Ma X; Thela SR; Zhao F; Yao B; Wen Z; Jin P; Zhao J; Chen L
• Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging.
  bioRxiv
  07/23/2024 Authors: Charles S; Jackson-Holmes E; Sun G; Zhou Y; Siciliano B; Niu W; Han H; Nikitina A; Kemp ML; Wen Z
• Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of Tcells in Parkinson's disease.
  iScience Volume: 27 Page(s): 110243
  07/19/2024 Authors: Chen Z; Li W; Meng B; Xu C; Huang Y; Li G; Wen Z; Liu J; Mao Z
• Modeling tuberous sclerosis complex with human induced pluripotent stem cells.
  World J Pediatr Volume: 20 Page(s): 208 - 218
  03/01/2024 Authors: Niu W; Siciliano B; Wen Z
• Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer's disease with real-world clinical validation.
  NPJ Digit Med Volume: 7 Page(s): 46
  02/26/2024 Authors: Yan C; Grabowska ME; Dickson AL; Li B; Wen Z; Roden DM; Michael Stein C; Emb PJ; Peterson JF; Feng Q
• FMRP phosphorylation modulates neuronal translation through YTHDF1.
  Mol Cell Volume: 83 Page(s): 4304 - 4317.e8
  12/07/2023 Authors: Zou Z; Wei J; Chen Y; Kang Y; Shi H; Yang F; Shi Z; Chen S; Zhou Y; Sepich-Poore C
• Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
  Res Sq
  11/21/2023 Authors: Chen X; Xie L; Sheehy R; Xiong Y; Muneer A; Wrobel J; Park K-S; Liu J; Velez J; Luo Y
• 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience.
  Neuron Volume: 111 Page(s): 2831 - 2846.e10
  09/20/2023 Authors: Kumar A; Karuppagounder SS; Chen Y; Corona C; Kawaguchi R; Cheng Y; Balkaya M; Sagdullaev BT; Wen Z; Stuart C
• Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
  Sci Adv Volume: 9 Page(s): eadh0558
  08/18/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
• The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
  Brain Behav Immun Volume: 112 Page(s): 175 - 187
  08/01/2023 Authors: Teng P; Li Y; Ku L; Wang F; Goldsmith DR; Wen Z; Yao B; Feng Y
• Leveraging Generative AI to Prioritize Drug Repurposing Candidates: Validating Identified Candidates for Alzheimer's Disease in Real-World Clinical Datasets.
  Res Sq
  07/14/2023 Authors: Wei W-Q; Yan C; Grabowska M; Dickson A; Li B; Wen Z; Roden D; Stein C; Emb P; Peterson J
• Electrophysiological and morphological characterization of single neurons in intact human brain organoids.
  J Neurosci Methods Volume: 394 Page(s): 109898
  07/01/2023 Authors: Landry CR; Yip MC; Zhou Y; Niu W; Wang Y; Yang B; Wen Z; Forest CR
• Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
  bioRxiv
  05/26/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
• APOE expression and secretion are modulated by mitochondrial dysfunction.
  Elife Volume: 12
  05/12/2023 Authors: Wynne ME; Ogunbona O; Lane AR; Gokhale A; Zlatic SA; Xu C; Wen Z; Duong DM; Rayaprolu S; Ivanova A
• Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders.
  Front Psychiatry Volume: 14 Page(s): 1291115
  01/01/2023 Authors: Michalski C; Wen Z
• Drug repurposing for Alzheimer's disease from 2012-2022-a 10-year literature review.
  Front Pharmacol Volume: 14 Page(s): 1257700
  01/01/2023 Authors: Grabowska ME; Huang A; Wen Z; Li B; Wei W-Q
• Interleukin-6 Decreases Dopamine Availability and Gene Pathways Related to Vesicular Transport and Release in Human Pluripotent Stem Cell Derived Dopaminergic Neurons
  Volume: 47 Page(s): 188 - 188
  12/01/2022 Authors: Miller A; Lucido M; Xu CC; Huang Y; Niu W; Wen Z
• Expression of expanded GGC repeats within NOTCH2NLC causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease.
  Sci Adv Volume: 8 Page(s): eadd6391
  11/25/2022 Authors: Liu Q; Zhang K; Kang Y; Li Y; Deng P; Li Y; Tian Y; Sun Q; Tang Y; Xu K
• The mitochondrial RNA granule modulates manganese-dependent cell toxicity.
  Mol Biol Cell Volume: 33 Page(s): ar108
  10/01/2022 Authors: Werner E; Gokhale A; Ackert M; Xu C; Wen Z; Roberts AM; Roberts BR; Vrailas-Mortimer A; Crocker A; Faundez V
• Intrinsic antiviral immunity of barrier cells revealed by an iPSC-derived blood-brain barrier cellular model.
  Cell Rep Volume: 39 Page(s): 110885
  05/31/2022 Authors: Cheng Y; Medina A; Yao Z; Basu M; Natekar JP; Lang J; Sanchez E; Nkembo MB; Xu C; Qian X
• Across Dimensions: Developing 2D and 3D Human iPSC-Based Models of Fragile X Syndrome.
  Cells Volume: 11
  05/24/2022 Authors: Lee A; Xu J; Wen Z; Jin P
• Schizophrenia: a disorder of broken brain bioenergetics.
  Mol Psychiatry Volume: 27 Page(s): 2393 - 2404
  05/01/2022 Authors: Henkel ND; Wu X; O'Donovan SM; Devine EA; Jiron JM; Rowland LM; Sarnyai Z; Ramsey AJ; Wen Z; Hahn MK
• Editorial: Genetics and epigenetics of psychiatric diseases-volume II.
  Front Genet Volume: 13 Page(s): 1059855
  01/01/2022 Authors: Li Q; Gai Y; Yue W; Wen Z; Zhao C
• A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
  Nat Neurosci Volume: 24 Page(s): 1377 - 1391
  10/01/2021 Authors: Kang Y; Zhou Y; Li Y; Han Y; Xu J; Niu W; Li Z; Liu S; Feng H; Huang W
• Role of Astrocytes in Major Neuropsychiatric Disorders.
  Neurochem Res Volume: 46 Page(s): 2715 - 2730
  10/01/2021 Authors: Zhang X; Alnafisah RS; Hamoud A-RA; Shukla R; Wen Z; McCullumsmith RE; O'Donovan SM
• Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus.
  J Neurosci Volume: 41 Page(s): 6596 - 6616
  08/04/2021 Authors: Gokhale A; Lee CE; Zlatic SA; Freeman AAH; Shearing N; Hartwig C; Ogunbona O; Bassell JL; Wynne ME; Werner E
• LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia.
  Mol Psychiatry Volume: 26 Page(s): 4511 - 4528
  08/01/2021 Authors: Ni C; Jiang W; Wang Z; Wang Z; Zhang J; Zheng X; Liu Z; Ou H; Jiang T; Liang W
• Craniofacial features of 3q29 deletion syndrome: Application of next-generation phenotyping technology.
  Am J Med Genet A Volume: 185 Page(s): 2094 - 2101
  07/01/2021 Authors: Mak BC; Sanchez Russo R; Gambello MJ; Fleischer N; Black ED; Leslie E; Murphy MM; Emory 3q29 Project; Mulle JG
• TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response.
  Mol Psychiatry Volume: 26 Page(s): 3122 - 3133
  07/01/2021 Authors: Ho M-F; Zhang C; Zhang L; Wei L; Zhou Y; Moon I; Geske JR; Choi D-S; Biernacka J; Frye M
• Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome.
  Transl Psychiatry Volume: 11 Page(s): 357
  06/15/2021 Authors: Sefik E; Purcell RH; Emory 3q29 Project; Walker EF; Bassell GJ; Mulle JG
• Deep phenotyping in 3q29 deletion syndrome: recommendations for clinical care.
  Genet Med Volume: 23 Page(s): 872 - 880
  05/01/2021 Authors: Sanchez Russo R; Gambello MJ; Murphy MM; Aberizk K; Black E; Burrell TL; Carlock G; Cubells JF; Epstein MT; Espana R
• Author Correction: Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation.
  Nat Commun Volume: 12 Page(s): 2570
  04/30/2021 Authors: Kim N-S; Wen Z; Liu J; Zhou Y; Guo Z; Xu C; Lin Y-T; Yoon K-J; Park J; Cho M
• 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.
  Cell Rep Volume: 35 Page(s): 109042
  04/27/2021 Authors: Kuehner JN; Chen J; Bruggeman EC; Wang F; Li Y; Xu C; McEachin ZT; Li Z; Chen L; Hales CM
• Induced pluripotent stem cells from subjects with Lesch-Nyhan disease.
  Sci Rep Volume: 11 Page(s): 8523
  04/19/2021 Authors: Sutcliffe DJ; Dinasarapu AR; Visser JE; Hoed JD; Seifar F; Joshi P; Ceballos-Picot I; Sardar T; Hess EJ; Sun YV
• Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
  Cell Rep Volume: 35 Page(s): 108991
  04/13/2021 Authors: Raj N; McEachin ZT; Harousseau W; Zhou Y; Zhang F; Merritt-Garza ME; Taliaferro JM; Kalinowska M; Marro SG; Hales CM
• Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.
  Mol Psychiatry Volume: 26 Page(s): 1346 - 1360
  04/01/2021 Authors: Wang X; Ye F; Wen Z; Guo Z; Yu C; Huang W-K; Rojas Ringeling F; Su Y; Zheng W; Zhou G
• Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation.
  Nat Commun Volume: 12 Page(s): 1398
  03/03/2021 Authors: Kim N-S; Wen Z; Liu J; Zhou Y; Guo Z; Xu C; Lin Y-T; Yoon K-J; Park J; Cho M
• Brain Organoids: Studying Human Brain Development and Diseases in a Dish.
  Stem Cells Int Volume: 2021 Page(s): 5902824
  01/01/2021 Authors: Xu J; Wen Z
• Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.
  Hum Mol Genet Volume: 29 Page(s): 2579 - 2595
  08/29/2020 Authors: Inglis GAS; Zhou Y; Patterson DG; Scharer CD; Han Y; Boss JM; Wen Z; Escayg A
• Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases.
  Mol Cell Volume: 79 Page(s): 521 - 534.e15
  08/06/2020 Authors: Lu L; Liu X; Huang W-K; Giusti-Rodrguez P; Cui J; Zhang S; Xu W; Wen Z; Ma S; Rosen JD
• Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
  Neuron Volume: 107 Page(s): 292 - 305.e6
  07/22/2020 Authors: McEachin ZT; Gendron TF; Raj N; Garca-Murias M; Banerjee A; Purcell RH; Ward PJ; Todd TW; Merritt-Garza ME; Jansen-West K
• Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation.
  Cell Stem Cell Volume: 26 Page(s): 766 - 781.e9
  05/07/2020 Authors: Qian X; Su Y; Adam CD; Deutschmann AU; Pather SR; Goldberg EM; Su K; Li S; Lu L; Jacob F
• Comprehensive phenotyping of neuropsychiatric traits in a multiplex 3q29 deletion family: a case report.
  BMC Psychiatry Volume: 20 Page(s): 184
  04/22/2020 Authors: Murphy MM; Burrell TL; Cubells JF; Epstein MT; Espana R; Gambello MJ; Goines K; Klaiman C; Koh S; Russo RS
• Targeting Hsc70-based autophagy to eliminate amyloid oligomers.
  Biochem Biophys Res Commun Volume: 524 Page(s): 923 - 928
  04/16/2020 Authors: Dou J; Su P; Xu C; Wen Z; Mao Z; Li W
• Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication.
  J Virol Volume: 93
  10/15/2019 Authors: Hammack C; Ogden SC; Madden JC; Medina A; Xu C; Phillips E; Son Y; Cone A; Giovinazzi S; Didier RA
• Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia.
  Mol Omics Volume: 15 Page(s): 173 - 188
  06/10/2019 Authors: Bentea E; Depasquale EAK; O'Donovan SM; Sullivan CR; Simmons M; Meador-Woodruff JH; Zhou Y; Xu C; Bai B; Peng J
• Connectivity Analyses of Bioenergetic Changes in Schizophrenia: Identification of Novel Treatments.
  Mol Neurobiol Volume: 56 Page(s): 4492 - 4517
  06/01/2019 Authors: Sullivan CR; Mielnik CA; O'Donovan SM; Funk AJ; Bentea E; DePasquale EA; Alganem K; Wen Z; Haroutunian V; Katsel P
• Transcriptome Profile in iPSC-Derived Astrocytes of TCF7L2, a Transcription Factor Associated With Bipolar Disorder, Reveals Relationship With Neural Function
  Volume: 85 Page(s): S179 - S179
  05/15/2019 Authors: Liu D; Thanh TN; Gao H; Ye Z; Lee J-H; Yan H; Ordog T; Ho M-F; Wen Z; Coombes B
• Altered DNA methylation of the AluY subfamily in schizophrenia and bipolar disorder.
  Epigenomics Volume: 11 Page(s): 581 - 586
  05/01/2019 Authors: Li S; Zong L; Hou Y; Zhang W; Zhou L; Yang Q; Wang L; Jiang W; Li Q; Huang X
• A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data.
  Nat Neurosci Volume: 22 Page(s): 691 - 699
  05/01/2019 Authors: Wang Q; Chen R; Cheng F; Wei Q; Ji Y; Yang H; Zhong X; Tao R; Wen Z; Sutcliffe JS
• Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.
  J Neurosci Volume: 39 Page(s): 3561 - 3581
  05/01/2019 Authors: Gokhale A; Hartwig C; Freeman AAH; Bassell JL; Zlatic SA; Sapp Savas C; Vadlamudi T; Abudulai F; Pham TT; Crocker A
• Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia.
  Sci Rep Volume: 9 Page(s): 5087
  03/25/2019 Authors: Sullivan CR; Mielnik CA; Funk A; O'Donovan SM; Bentea E; Pletnikov M; Ramsey AJ; Wen Z; Rowland LM; McCullumsmith RE
• KETAMINE AND SEX HORMONES ALTER GENE EXPRESSION PROFILES OF HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED ASTROCYTES: MOLECULAR LINKS TO KETAMINE'S MECHANISM OF ACTION.
  Volume: 105 Page(s): S21 - S21
  03/01/2019 Authors: Ho M-F; Zhang C; Xu C; Ji Y; Nelson T; Skime M; Zhang L; Wang L; Wen Z; Li H
• KETAMINE AND SEX HORMONES ALTER GENE EXPRESSION PROFILES OF HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED ASTROCYTES: MOLECULAR LINKS TO KETAMINE'S MECHANISM OF ACTION.
  Volume: 105 Page(s): S59 - S59
  03/01/2019 Authors: Ho M-F; Zhang C; Xu C; Ji Y; Nelson T; Skime M; Zhang L; Wang L; Wen Z; Li H
• Epigenetic Regulations in Neuropsychiatric Disorders.
  Front Genet Volume: 10 Page(s): 268
  01/01/2019 Authors: Kuehner JN; Bruggeman EC; Wen Z; Yao B
• Mechanisms Underlying Dysregulation of miR-132 in Alzheimer's Disease.
  Biomed J Sci Tech Res Volume: 22 Page(s): 17018 - 17020
  01/01/2019 Authors: Song Q; Dou J; Mao Z; Wen Z; Li W
• Kinase Network Dysregulation in a Human Induced Pluripotent Stem Cell Model of DISC1 Schizophrenia
  Volume: 43 Page(s): S473 - S473
  12/01/2018 Authors: Bentea E; Depasquale E; Odonovan S; Sullivan C; Simmons M; Meador-Woodruff J; Meller J; Zhou Y; Xu C; Wen Z
• KINASE NETWORK DYSREGULATION IN SCHIZOPHRENIA: IMPLICATIONS FOR NEW TREATMENT STRATEGIES
  Volume: 44 Page(s): S299 - S299
  04/01/2018 Authors: Bentea E; Depasquale E; Meller J; Wen Z; McCullumsmith RE
• Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development.
  Transl Psychiatry Volume: 7 Page(s): 1293
  12/18/2017 Authors: Chen X; Ku L; Mei R; Liu G; Xu C; Wen Z; Zhao X; Wang F; Xiao L; Feng Y
• Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.
  Cell Stem Cell Volume: 21 Page(s): 604 - 617.e5
  11/02/2017 Authors: Bao H; Asrican B; Li W; Gu B; Wen Z; Lim S-A; Haniff I; Ramakrishnan C; Deisseroth K; Philpot B
• Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.
  Cell Stem Cell Volume: 21 Page(s): 349 - 358.e6
  09/07/2017 Authors: Yoon K-J; Song G; Qian X; Pan J; Xu D; Rho H-S; Kim N-S; Habela C; Zheng L; Jacob F
• Zika virus directly infects peripheral neurons and induces cell death.
  Nat Neurosci Volume: 20 Page(s): 1209 - 1212
  09/01/2017 Authors: Oh Y; Zhang F; Wang Y; Lee EM; Choi IY; Lim H; Mirakhori F; Li R; Huang L; Xu T
• Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways.
  Hum Mol Genet Volume: 26 Page(s): 2634 - 2648
  07/15/2017 Authors: Shao L; Lu B; Wen Z; Teng S; Wang L; Zhao Y; Wang L; Ishizuka K; Xu X; Sawa A
• Using Human iPSCs for Psychiatric Disorder Disease Modeling and Mechanism-Based Drug Discovery
  Volume: 81 Page(s): S290 - S291
  05/15/2017 Authors: Wen Z; Guo Z; Wang X; Kim N; Ross C; Margolis R; Christian K; Chen G; Zheng W; Xia M
• Modeling neurodevelopmental and psychiatric diseases with human iPSCs.
  J Neurosci Res Volume: 95 Page(s): 1097 - 1109
  05/01/2017 Authors: Wen Z
• How does Zika virus cause microcephaly?
  Genes Dev Volume: 31 Page(s): 849 - 861
  05/01/2017 Authors: Wen Z; Song H; Ming G-L
• A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model.
  PLoS One Volume: 12 Page(s): e0174074
  01/01/2017 Authors: Yuan X; Li Z; Baines AC; Gavriilaki E; Ye Z; Wen Z; Braunstein EM; Biesecker LG; Cheng L; Dong X
• Deficits in Core Synaptic Signatures in a Human iPSC Model of Major Mental Disorders
  Volume: 41 Page(s): S234 - S235
  12/01/2016 Authors: Wen Z; Ha NN; Guo Z; Lalli M; Chen G; Kosik K; Song H; Ming G-L
• Molecular signatures associated with ZIKV exposure in human cortical neural progenitors.
  Nucleic Acids Res Volume: 44 Page(s): 8610 - 8620
  10/14/2016 Authors: Zhang F; Hammack C; Ogden SC; Cheng Y; Lee EM; Wen Z; Qian X; Nguyen HN; Li Y; Yao B
• Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.
  Nat Med Volume: 22 Page(s): 1101 - 1107
  10/01/2016 Authors: Xu M; Lee EM; Wen Z; Cheng Y; Huang W-K; Qian X; Tcw J; Kouznetsova J; Ogden SC; Hammack C
• Adult Neurogenesis and Psychiatric Disorders.
  Cold Spring Harb Perspect Biol Volume: 8
  09/01/2016 Authors: Kang E; Wen Z; Song H; Christian KM; Ming G-L
• Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.
  Cell Volume: 165 Page(s): 1238 - 1254
  05/19/2016 Authors: Qian X; Nguyen HN; Song MM; Hadiono C; Ogden SC; Hammack C; Yao B; Hamersky GR; Jacob F; Zhong C
• Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.
  Cell Stem Cell Volume: 18 Page(s): 587 - 590
  05/05/2016 Authors: Tang H; Hammack C; Ogden SC; Wen Z; Qian X; Li Y; Yao B; Shin J; Zhang F; Lee EM
• Modeling of Major Mental Disorders Using Human iPSCs Derived from Patients with a Defined DISC1 Mutation
  Volume: 79 Page(s): 16S - 16S
  05/01/2016 Authors: Wen Z; Nguyen HN; Guo Z; Lalli MA; Chen G; Kosik KS; Song H; Ming G-L
• Patient iPSCs: a new discovery tool for Smith-Lemli-Opitz syndrome.
  Nat Med Volume: 22 Page(s): 343 - 344
  04/01/2016 Authors: Wen Z; Song H; Ming G-L
• The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.
  Nat Commun Volume: 7 Page(s): 10965
  03/11/2016 Authors: Murai K; Sun G; Ye P; Tian E; Yang S; Cui Q; Sun G; Trinh D; Sun O; Hong T
• Modeling psychiatric disorders with patient-derived iPSCs.
  Curr Opin Neurobiol Volume: 36 Page(s): 118 - 127
  02/01/2016 Authors: Wen Z; Christian KM; Song H; Ming G-L
• Synaptic dysregulation in a human iPS cell model of mental disorders.
  Nature Volume: 515 Page(s): 414 - 418
  11/20/2014 Authors: Wen Z; Nguyen HN; Guo Z; Lalli MA; Wang X; Su Y; Kim N-S; Yoon K-J; Shin J; Zhang C
• Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.
  Cell Stem Cell Volume: 15 Page(s): 79 - 91
  07/03/2014 Authors: Yoon K-J; Nguyen HN; Ursini G; Zhang F; Kim N-S; Wen Z; Makri G; Nauen D; Shin JH; Park Y
• Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.
  Nat Neurosci Volume: 16 Page(s): 1728 - 1730
  12/01/2013 Authors: Song J; Sun J; Moss J; Wen Z; Sun GJ; Hsu D; Zhong C; Davoudi H; Christian KM; Toni N
• Toward a 3D model of human brain development for studying gene/environment interactions.
  Stem Cell Res Ther Volume: 4 Suppl 1 Page(s): S4
  01/01/2013 Authors: Hogberg HT; Bressler J; Christian KM; Harris G; Makri G; O'Driscoll C; Pamies D; Smirnova L; Wen Z; Hartung T
• Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
  Cell Volume: 148 Page(s): 1051 - 1064
  03/02/2012 Authors: Kim JY; Liu CY; Zhang F; Duan X; Wen Z; Song J; Feighery E; Lu B; Rujescu D; St Clair D
• Regulation of chemotropic guidance of nerve growth cones by microRNA.
  Mol Brain Volume: 4 Page(s): 40
  11/03/2011 Authors: Han L; Wen Z; Lynn RC; Baudet M-L; Holt CE; Sasaki Y; Bassell GJ; Zheng JQ
• Postsynaptic TRPC1 function contributes to BDNF-induced synaptic potentiation at the developing neuromuscular junction.
  J Neurosci Volume: 31 Page(s): 14754 - 14762
  10/12/2011 Authors: McGurk JS; Shim S; Kim JY; Wen Z; Song H; Ming G-L
• Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation.
  Mol Psychiatry Volume: 16 Page(s): 358 - 360
  04/01/2011 Authors: Chiang C-H; Su Y; Wen Z; Yoritomo N; Ross CA; Margolis RL; Song H; Ming G-L
• Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning.
  J Neurosci Volume: 30 Page(s): 9349 - 9358
  07/14/2010 Authors: Sasaki Y; Welshhans K; Wen Z; Yao J; Xu M; Goshima Y; Zheng JQ; Bassell GJ
• BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin.
  J Cell Biol Volume: 178 Page(s): 107 - 119
  07/02/2007 Authors: Wen Z; Han L; Bamburg JR; Shim S; Ming G-L; Zheng JQ
• Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP.
  J Cell Biol Volume: 176 Page(s): 101 - 111
  01/01/2007 Authors: Han J; Han L; Tiwari P; Wen Z; Zheng JQ
• An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance.
  Nat Neurosci Volume: 9 Page(s): 1265 - 1273
  10/01/2006 Authors: Yao J; Sasaki Y; Wen Z; Bassell GJ; Zheng JQ
• Directional guidance of nerve growth cones.
  Curr Opin Neurobiol Volume: 16 Page(s): 52 - 58
  02/01/2006 Authors: Wen Z; Zheng JQ
• A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance.
  Neuron Volume: 43 Page(s): 835 - 846
  09/16/2004 Authors: Wen Z; Guirland C; Ming G-L; Zheng JQ
• Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro.
  Cell Biol Int Volume: 28 Page(s): 63 - 67
  01/01/2004 Authors: Zhou C; Wen Z-X; Shi D-M; Xie Z-P
• Green fluorescent protein-labeled mapping of neural stem cells migrating towards damaged areas in the adult central nervous system.
  Cell Biol Int Volume: 27 Page(s): 943 - 945
  01/01/2003 Authors: Zhou C; Wen Z-X; Wang Z-P; Guo X; Shi D-M; Zuo H-C; Xie Z-P