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Profile

Zhengqi Wang

  • Department of Pediatrics
    Assistant Professor
  • zhengqi.wang@emory.edu
  • Bunting Laboratory
  • Aflac Cancer and Blood Disorders Center
    Pediatrics
    1760 Haygood Drive
Head shot of Zhengqi Wang

Academic Appointment

  • Assistant Professor of Pediatrics, Emory University

Education

Degrees

  • PhD from University of Notre Dame
  • BS from East China University of Science & Technology
  • MS from East China University of Science & Technology

Research

Focus

  • My current work is focused on studies of STAT5 and its function in signaling mechanisms in leukemogenesis, and hematopoietic stem cell biology and transplantation.

Publications

  • Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia.
    Antioxidants (Basel) Volume: 10
    06/15/2021 Authors: Wang Z; Mi T; Bradley HL; Metts J; Sabnis H; Zhu W; Arbiser J; Bunting KD
  • Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.
    Front Immunol Volume: 10 Page(s): 486
    01/01/2019 Authors: Wang Z; Vaughan TY; Zhu W; Chen Y; Fu G; Medrzycki M; Nishio H; Bunting ST; Hankey-Giblin PA; Nusrat A
  • The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential.
    Cancers (Basel) Volume: 10
    09/27/2018 Authors: Mi T; Wang Z; Bunting KD
  • Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.
    J Biol Chem Volume: 293 Page(s): 9636 - 9650
    06/22/2018 Authors: Lee JA; Wang Z; Sambo D; Bunting KD; Pallas DC
  • Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells.
    Sci Rep Volume: 7 Page(s): 4447
    06/30/2017 Authors: Metts J; Bradley HL; Wang Z; Shah NP; Kapur R; Arbiser JL; Bunting KD
  • Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations.
    Oncotarget Volume: 8 Page(s): 22477 - 22482
    04/04/2017 Authors: Wang Z; Bunting KD
  • STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't.
    Cancer Cell Microenviron Volume: 3
    01/01/2016 Authors: Wang Z; Bunting KD
  • Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.
    Oncotarget Volume: 6 Page(s): 28961 - 28972
    10/06/2015 Authors: Wang Z; Medrzycki M; Bunting ST; Bunting KD
  • AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.
    Oncotarget Volume: 6 Page(s): 20697 - 20710
    08/21/2015 Authors: Park J; Schlederer M; Schreiber M; Ice R; Merkel O; Bilban M; Hofbauer S; Kim S; Addison J; Zou J
  • Dysregulated Macrophage Pro-Inflammatory Cytokine Production and Chronic Colitis in Mice Lacking Both Gab2 and Gab3
    Volume: 124
    12/06/2014 Authors: Vaughan-Whitley TY; Nishio H; Imhoff B; Wang Z; Bunting ST; Hankey-Giblin P; Nusrat A; Parkos CA; Bunting KD
  • Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence.
    Blood Volume: 123 Page(s): 1002 - 1011
    02/13/2014 Authors: Qing Y; Wang Z; Bunting KD; Gerson SL
  • STAT5 N-domain deleted isoforms are naturally occurring hypomorphs partially rescued in hematopoiesis by transgenic Bcl-2 expression.
    Am J Blood Res Volume: 4 Page(s): 20 - 26
    01/01/2014 Authors: Wang Z; Li G; Bunting KD
  • STAT5 in hematopoietic stem cell biology and transplantation.
    JAKSTAT Volume: 2 Page(s): e27159
    10/01/2013 Authors: Wang Z; Bunting KD
  • Deletion of Gab adaptor proteins leads to impaired macrophage development and chronic colitis
    Volume: 190
    05/01/2013 Authors: Vaughan T; Imhoff B; Wang Z; Denning T; Bunting K
  • Mutation of STAT1/3 binding sites in gp130(FXXQ) knock-in mice does not alter hematopoietic stem cell repopulation or self-renewal potential.
    Am J Stem Cells Volume: 1 Page(s): 146 - 153
    06/30/2012 Authors: Wang Z; Kang Z; Zhang Y; Tse W; Bunting KD
  • HIF-1 deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency.
    Blood Volume: 119 Page(s): 2789 - 2798
    03/22/2012 Authors: Du J; Chen Y; Li Q; Han X; Cheng C; Wang Z; Danielpour D; Dunwoodie SL; Bunting KD; Yang Y-C
  • Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.
    J Biol Chem Volume: 287 Page(s): 2045 - 2054
    01/13/2012 Authors: Pullen NA; Barnstein BO; Falanga YT; Wang Z; Suzuki R; Tamang TDL; Khurana MC; Harry EA; Draber P; Bunting KD
  • Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a
    Volume: 118 Page(s): 1456 - 1456
    11/18/2011 Authors: Nivarthi H; Tsyrulnyk A; Warsch W; Wang Z; Winkler S; Kenner L; Mueller M; Baum C; Bunting KD; Sexl V
  • STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma
    Volume: 118 Page(s): 419 - 419
    11/18/2011 Authors: Wang Z; Li G; Kang Z; Bunting ST; Tse W; Bunting KD
  • Cited2 Regulates Hematopoietic Stem Cell Quiescence Through HIF-1 alpha Dependent and Independent Pathways
    Volume: 118 Page(s): 416 - 417
    11/18/2011 Authors: Du J; Chen Y; Li Q; Wang Z; Dunwoodie S; Bunting KD; Yang Y-C
  • Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
    J Biol Chem Volume: 286 Page(s): 20606 - 20614
    06/10/2011 Authors: Liu Z; Yang A; Wang Z; Bunting KD; Davuluri G; Green MR; Devireddy LR
  • Multiple Apoptotic Defects In Hematopoietic Cellsfrom Mice Lacking Lipocalin 24p3
    Volume: 116 Page(s): 662 - 662
    11/19/2010 Authors: Devireddy LR; Liu Z; Ciocea A; Yang A; Wang Z; Bunting KD; Green M
  • Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin.
    Leukemia Volume: 24 Page(s): 1397 - 1405
    08/01/2010 Authors: Li G; Miskimen KL; Wang Z; Xie XY; Tse W; Gouilleux F; Moriggl R; Bunting KD
  • STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.
    Blood Volume: 115 Page(s): 1416 - 1424
    02/18/2010 Authors: Li G; Miskimen KL; Wang Z; Xie XY; Brenzovich J; Ryan JJ; Tse W; Moriggl R; Bunting KD
  • Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.
    PLoS One Volume: 5 Page(s): e9152
    02/10/2010 Authors: Li G; Wang Z; Miskimen KL; Zhang Y; Tse W; Bunting KD
  • Genetic and Pharmacologic Targeting of STAT5/Gab2/PI3K/mTOR Signaling in a Mouse Myeloproliferative Disease Model
    Volume: 114 Page(s): 1501 - 1501
    11/20/2009 Authors: Li G; Wang Z; Miskimen KL; Xie XY; Tse W; Gouilleux F; Moriggl R; Bunting KD
  • STAT5 Requires the N-Domain for Suppression of miR15/16, Induction of Bcl-2, and Survival Signaling in Myeloproliferative Disease
    Volume: 114 Page(s): 92 - 93
    11/20/2009 Authors: Li G; Miskimen KL; Wang Z; Xie XY; Brenzovich J; Ryan JJ; Tse W; Moriggl R; Bunting KD
  • Regulation of Hematopoietic Stem Cell Quiescence by Ku70.
    Volume: 114 Page(s): 1397 - 1397
    11/20/2009 Authors: Qing Y; Wang Z; Liu M; Bunting KD; Gerson SL
  • Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.
    Blood Volume: 113 Page(s): 4856 - 4865
    05/14/2009 Authors: Wang Z; Li G; Tse W; Bunting KD
  • IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen.
    J Immunol Volume: 182 Page(s): 2835 - 2841
    03/01/2009 Authors: Ohmori K; Luo Y; Jia Y; Nishida J; Wang Z; Bunting KD; Wang D; Huang H
  • STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
    Blood Volume: 112 Page(s): 1832 - 1843
    09/01/2008 Authors: Cohen PA; Koski GK; Czerniecki BJ; Bunting KD; Fu X-Y; Wang Z; Zhang W-J; Carter CS; Awad M; Distel CA
  • Dexamethasone-induced inositol 1,4,5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis.
    J Biol Chem Volume: 283 Page(s): 10357 - 10365
    04/18/2008 Authors: Davis MC; McColl KS; Zhong F; Wang Z; Malone MH; Distelhorst CW
  • Hematopoietic stem cell transplant into non-myeloablated W/Wv mice to detect steady-state engraftment defects.
    Methods Mol Biol Volume: 430 Page(s): 171 - 181
    01/01/2008 Authors: Wang Z; Bunting KD
  • Conditional deletion of STAT5 in non-myeloablated recipient mice promotes donor hematopoietic stem cell engraftment
    Volume: 110 Page(s): 60A - 60A
    11/16/2007 Authors: Wang Z; Li G; Haviernikova E; Tse W; Bunting KD
  • Physiologically significant genetic interaction between STAT5 and Gab2 during normal and pathologic hematopoiesis
    Volume: 110 Page(s): 34A - 35A
    11/16/2007 Authors: Li G; Wang Z; Zhang Y; Haviemikova E; Tse W; Bunting KD
  • STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.
    Exp Hematol Volume: 35 Page(s): 1684 - 1694
    11/01/2007 Authors: Li G; Wang Z; Zhang Y; Kang Z; Haviernikova E; Cui Y; Hennighausen L; Moriggl R; Wang D; Tse W
  • Abnormal hematopoiesis in Gab2 mutant mice.
    Blood Volume: 110 Page(s): 116 - 124
    07/01/2007 Authors: Zhang Y; Diaz-Flores E; Li G; Wang Z; Kang Z; Haviernikova E; Rowe S; Qu C-K; Tse W; Shannon KM
  • Stat5 expression is required for IgE-mediated mast cell function.
    J Immunol Volume: 177 Page(s): 3421 - 3426
    09/01/2006 Authors: Barnstein BO; Li G; Wang Z; Kennedy S; Chalfant C; Nakajima H; Bunting KD; Ryan JJ
  • Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis.
    Oncogene Volume: 25 Page(s): 1903 - 1913
    03/23/2006 Authors: Wang Z; Rong YP; Malone MH; Davis MC; Zhong F; Distelhorst CW
  • The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis.
    J Biol Chem Volume: 279 Page(s): 52850 - 52859
    12/17/2004 Authors: Malone MH; Wang Z; Distelhorst CW
  • Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals.
    J Biol Chem Volume: 278 Page(s): 27053 - 27058
    07/18/2003 Authors: Wang Z; Malone MH; Thomenius MJ; Zhong F; Xu F; Distelhorst CW
  • Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis.
    J Biol Chem Volume: 278 Page(s): 23861 - 23867
    06/27/2003 Authors: Wang Z; Malone MH; He H; McColl KS; Distelhorst CW
  • Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins.
    J Biol Chem Volume: 278 Page(s): 6243 - 6250
    02/21/2003 Authors: Thomenius MJ; Wang NS; Reineks EZ; Wang Z; Distelhorst CW
  • Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium.
    Am J Physiol Gastrointest Liver Physiol Volume: 280 Page(s): G149 - G156
    01/01/2001 Authors: Suh E; Wang Z; Swain GP; Tenniswood M; Traber PG
  • Alcohol at moderate levels decreases fibrinogen expression in vivo and in vitro.
    Alcohol Clin Exp Res Volume: 23 Page(s): 1927 - 1932
    12/01/1999 Authors: Wang Z; Barker TH; Fuller GM
  • Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes.
    Proc Natl Acad Sci U S A Volume: 96 Page(s): 3059 - 3064
    03/16/1999 Authors: Pieper AA; Brat DJ; Krug DK; Watkins CC; Gupta A; Blackshaw S; Verma A; Wang ZQ; Snyder SH
  • Clusterin in the male reproductive tract.
    J Androl Volume: 19 Page(s): 508 - 516
    01/01/1998 Authors: Tenniswood M; Wang Z; Lakins J; Morrissey C; O'Sullivan J; Tang H
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