Publications

• PI3P: Rising to the (DPR) challenge in C9-ALS/FTD.
  Neuron Volume: 113 Page(s): 1301 - 1303
  05/07/2025 Authors: Parameswaran J; McEachin ZT
• ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression.
  Ann Clin Transl Neurol Volume: 12 Page(s): 714 - 723
  04/01/2025 Authors: Thomas EV; Han C; Kim WJ; Asress S; Li Y; Taylor JA; Gearing M; Fournier CN; McEachin ZT; Seyfried NT
• Imaging and Tracking RNA in Live Mammalian Cells via Fluorogenic Photoaffinity Labeling.
  ACS Chem Biol Volume: 20 Page(s): 707 - 720
  03/21/2025 Authors: Quillin AL; Karloff DB; Ayele TM; Flores TF; Chen G; McEachin ZT; Valdez-Sinon AN; Heemstra JM
• pTDP-43 levels correlate with cell type-specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients.
  Proc Natl Acad Sci U S A Volume: 122 Page(s): e2419818122
  03/04/2025 Authors: Wang H-LV; Xiang J-F; Yuan C; Veire AM; Gendron TF; Murray ME; Tansey MG; Hu J; Gearing M; Glass JD
• pTDP-43 levels correlate with cell type specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients.
  bioRxiv
  06/13/2024 Authors: Wang H-LV; Xiang J-F; Yuan C; Veire AM; Gendron TF; Murray ME; Tansey MG; Hu J; Gearing M; Glass JD
• Cryptic exon inclusion is a molecular signature ofLATE-NCin aging brains.
  Acta Neuropathol Volume: 147 Page(s): 29
  02/03/2024 Authors: Chung M; Carter EK; Veire AM; Dammer EB; Chang J; Duong DM; Raj N; Bassell GJ; Glass JD; Gendron TF
• TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.
  Sci Transl Med Volume: 16 Page(s): eadf9735
  01/17/2024 Authors: Marks JD; Ayuso VE; Carlomagno Y; Yue M; Todd TW; Hao Y; Li Z; McEachin ZT; Shantaraman A; Duong DM
• Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
  Sci Adv Volume: 9 Page(s): eadh0558
  08/18/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
• Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
  bioRxiv
  05/26/2023 Authors: Purcell RH; Sefik E; Werner E; King AT; Mosley TJ; Merritt-Garza ME; Chopra P; McEachin ZT; Karne S; Raj N
• Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy.
  eNeuro Volume: 9
  01/01/2022 Authors: Edokpolor KS; Banerjee A; McEachin ZT; Gu J; Kosti A; Arboleda JD; Garca PS; Wang ET; Bassell GJ
• 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.
  Cell Rep Volume: 35 Page(s): 109042
  04/27/2021 Authors: Kuehner JN; Chen J; Bruggeman EC; Wang F; Li Y; Xu C; McEachin ZT; Li Z; Chen L; Hales CM
• Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
  Cell Rep Volume: 35 Page(s): 108991
  04/13/2021 Authors: Raj N; McEachin ZT; Harousseau W; Zhou Y; Zhang F; Merritt-Garza ME; Taliaferro JM; Kalinowska M; Marro SG; Hales CM
• The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
  Neurobiol Dis Volume: 149 Page(s): 105228
  02/01/2021 Authors: Bakkar N; Starr A; Rabichow BE; Lorenzini I; McEachin ZT; Kraft R; Chaung M; Macklin-Isquierdo S; Wingfield T; Carhart B
• TBK1 interacts with tau and enhances neurodegeneration in tauopathy.
  J Biol Chem Volume: 296 Page(s): 100760
  01/01/2021 Authors: Abreha MH; Ojelade S; Dammer EB; McEachin ZT; Duong DM; Gearing M; Bassell GJ; Lah JJ; Levey AI; Shulman JM
• Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage.
  Neurobiol Dis Volume: 146 Page(s): 105085
  12/01/2020 Authors: Johnson MA; Deng Q; Taylor G; McEachin ZT; Chan AWS; Root J; Bassell GJ; Kukar T
• RNA-mediated toxicity in C9orf72 ALS and FTD.
  Neurobiol Dis Volume: 145 Page(s): 105055
  11/01/2020 Authors: McEachin ZT; Parameswaran J; Raj N; Bassell GJ; Jiang J
• Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
  Neuron Volume: 107 Page(s): 292 - 305.e6
  07/22/2020 Authors: McEachin ZT; Gendron TF; Raj N; Garca-Murias M; Banerjee A; Purcell RH; Ward PJ; Todd TW; Merritt-Garza ME; Jansen-West K
• Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration InVivo.
  Cell Rep Volume: 31 Page(s): 107616
  05/05/2020 Authors: Todd TW; McEachin ZT; Chew J; Burch AR; Jansen-West K; Tong J; Yue M; Song Y; Castanedes-Casey M; Kurti A
• CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.
  Commun Biol Volume: 3 Page(s): 33
  01/20/2020 Authors: Yun Y; Hong S-A; Kim K-K; Baek D; Lee D; Londhe AM; Lee M; Yu J; McEachin ZT; Bassell GJ
• Focal and dose-dependent neuroprotection in ALS mice following AAV2-neurturin delivery.
  Exp Neurol Volume: 323 Page(s): 113091
  01/01/2020 Authors: Gross SK; Shim BS; Bartus RT; Deaver D; McEachin Z; Btourn A; Boulis NM; Maragakis NJ
• A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses.
  Dis Model Mech Volume: 9 Page(s): 927 - 939
  09/01/2016 Authors: Preininger MK; Jha R; Maxwell JT; Wu Q; Singh M; Wang B; Dalal A; Mceachin ZT; Rossoll W; Hales CM
• Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
  Mol Neurodegener Volume: 11 Page(s): 46
  06/24/2016 Authors: Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W
• Intracerebroventricular delivery of self-complementary adeno-associated virus serotype 9 to the adult rat brain.
  Gene Ther Volume: 23 Page(s): 401 - 407
  05/01/2016 Authors: Donsante A; McEachin Z; Riley J; Leung CH; Kanz L; O'Connor DM; Boulis NM
• Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis.
  Methods Mol Biol Volume: 1382 Page(s): 399 - 408
  01/01/2016 Authors: McEachin ZT; Donsante A; Boulis N
• Assessing reproductive toxicity of two environmental toxicants with a novel in vitro human spermatogenic model.
  Stem Cell Res Volume: 14 Page(s): 347 - 355
  05/01/2015 Authors: Easley CA; Bradner JM; Moser A; Rickman CA; McEachin ZT; Merritt MM; Hansen JM; Caudle WM