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Profile

Zhiyong Lin

  • Department of Medicine
    Associate Professor
  • zhiyong.lin@emory.edu
  • Emory University
    Medicine
    1750 Haygood Drive, HSRB-II, N240
Head shot of Zhiyong Lin

Overview

Dr. Zhiyong Lin received his Ph.D. in Biomedical Sciences from Old Dominion University/Eastern Virginia Medical School in 2002. He then completed his postdoctoral training in cardiovascular biology with Dr. Mukesh Jain at Brigham and Womens Hospital/Harvard Medical School. In 2006, Dr. Lin accepted a faculty position within the Cardiovascular Research Institute at Case Western Reserve University School of Medicine. In 2010, under the auspices of both an American Heart Association Scientist Development Grant and an NIH K99/R00 award, Dr. Lin established his independent research laboratory. Dr. Lin joined the Division of Cardiology at Emory University as an Associate Professor in 2017.

The main focus of the Lin lab centers around the molecular mechanisms that govern vascular and hepatic function. Specifically, our work focuses on the regulatory roles of a matricellular family of proteins termed CCN (Cyr61, CTGF and Nov) in vascular biology. How do the expression patterns and matricellular interactions of CCNs (specifically CCN3) lead to biological consequences associated with vascular diseases such as atherosclerosis, restenosis, and aortic aneurysms and dissections? Ongoing efforts in the lab aim to gain in-depth insights into CCN function and how they influence cellular and organismal homeostasis.

Recently, we have expanded our efforts to investigate the role of protein phosphatases in vascular biology. We will leverage both pharmacologic and genetic approaches to dissect the molecular basis and functional consequences of protein phosphatases on vascular disease such as aortic aneurysm, with the overall goal of disease treatment through phosphatase manipulation. Another key area of interest centers on the regulation of alcohol metabolism in the liver as well as the regulation of hepatic function by CCN proteins.

Academic Appointment

  • Associate Professor, Department of Medicine, Emory University School of Medicine

Education

Degrees

  • PhD from Eastern Virginia Medical School
  • MS from Fujian Agriculture and Forestry University
  • BS from Fujian Agriculture and Forestry University

Research

Publications

  • PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome.
    Hypertension Volume: 82 Page(s): 665 - 679
    04/01/2025 Authors: Zhou X; Xu Q; Hu X; Klenotic PA; Valdivia A; Leshnower BG; Dong N; Narla G; Lin Z
  • Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis.
    Cardiovasc Res Volume: 120 Page(s): 2191 - 2207
    12/31/2024 Authors: Xu Q; Sun J; Holden CM; Neto HCF; Wang T; Zhang C; Fu Z; Joseph G; Shi R; Wang J
  • The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism.
    Redox Biol Volume: 73 Page(s): 103203
    07/01/2024 Authors: Paredes F; Williams HC; Liu X; Holden C; Bogan B; Wang Y; Crotty KM; Yeligar SM; Elorza AA; Lin Z
  • Protein Phosphatase 2A Activation Promotes Heart Transplant Acceptance in Mice.
    Transplantation Volume: 108 Page(s): e36 - e48
    03/01/2024 Authors: Zhou X; Xu Q; Li W; Dong N; Stomberski C; Narla G; Lin Z
  • Myeloid CCN3 protects against aortic valve calcification.
    Cell Commun Signal Volume: 21 Page(s): 14
    01/20/2023 Authors: Tu P; Xu Q; Zhou X; Villa-Roel N; Kumar S; Dong N; Jo H; Ou C; Lin Z
  • CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development.
    JCI Insight Volume: 8
    01/10/2023 Authors: Wang Y; Liu X; Xu Q; Xu W; Zhou X; Leask A; Lin Z
  • Anxa1 in smooth muscle cells protects against acute aortic dissection.
    Cardiovasc Res Volume: 118 Page(s): 1564 - 1582
    05/06/2022 Authors: Zhou C; Lin Z; Cao H; Chen Y; Li J; Zhuang X; Ma D; Ji L; Li W; Xu S
  • Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection.
    Eur Heart J Volume: 42 Page(s): 4373 - 4385
    11/07/2021 Authors: Cui H; Chen Y; Li K; Zhan R; Zhao M; Xu Y; Lin Z; Fu Y; He Q; Tang PC
  • Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.
    Volume: 135 Page(s): 2085 - 2097
    09/17/2021 Authors: Zhou X; Zhang C; Xie F; Wei W; Li R; Xu Q; Wang Y; Klenotic PA; Narla G; Dong N
  • Investigating the role of CCN3 in central nervous system myelination and remyelination
    Volume: 69 Page(s): E403 - E404
    07/01/2021 Authors: Gallardo NDLV; Penalva R; Dittmer M; Naughton M; Falconer J; Moffat J; de la Fuente AG; Hombrebueno JR; Lin Z; Perbal B
  • Protein Phosphatase 2A Deficiency in Macrophages Increases Foam Cell Formation and Accelerates Atherosclerotic Lesion Development.
    Front Cardiovasc Med Volume: 8 Page(s): 745009
    01/01/2021 Authors: Li R; Zhang C; Xie F; Zhou X; Hu X; Shi J; Du X; Lin Z; Dong N
  • Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination.
    Proc Natl Acad Sci U S A Volume: 117 Page(s): 18018 - 18028
    07/28/2020 Authors: de la Vega Gallardo N; Penalva R; Dittmer M; Naughton M; Falconer J; Moffat J; de la Fuente AG; Hombrebueno JR; Lin Z; Perbal B
  • The role of CCN3 during central nervous system myelination and remyelination
    Volume: 67 Page(s): E478 - E479
    07/01/2019 Authors: Gallardo NDLV; Penalva RG; Falconer J; Moffat J; Naughton M; Lin Z; Perbal B; Ingram RJ; Fitzgerald DC
  • Myeloid deficiency of CCN3 exacerbates liver injury in a mouse model of nonalcoholic fatty liver disease.
    J Cell Commun Signal Volume: 12 Page(s): 389 - 399
    03/01/2018 Authors: Wu W; Hu X; Zhou X; Klenotic PA; Zhou Q; Lin Z
  • CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis.
    Am J Pathol Volume: 187 Page(s): 1230 - 1237
    06/01/2017 Authors: Shi H; Zhang C; Pasupuleti V; Hu X; Prosdocimo DA; Wu W; Qing Y; Wu S; Mohammad H; Gerson SL
  • Emerging roles of CCN proteins in vascular development and pathology.
    J Cell Commun Signal Volume: 10 Page(s): 251 - 257
    09/01/2016 Authors: Klenotic PA; Zhang C; Lin Z
  • Matricellular protein CCN3 mitigates abdominal aortic aneurysm.
    J Clin Invest Volume: 126 Page(s): 1282 - 1299
    04/01/2016 Authors: Zhang C; van der Voort D; Shi H; Zhang R; Qing Y; Hiraoka S; Takemoto M; Yokote K; Moxon JV; Norman P
  • Myeloid Kruppel-like factor 2 deficiency exacerbates neurological dysfunction and neuroinflammation in a murine model of multiple sclerosis.
    J Neuroimmunol Volume: 274 Page(s): 234 - 239
    09/15/2014 Authors: Shi H; Sheng B; Zhang C; Nayak L; Lin Z; Jain MK; Atkins GB
  • The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2).
    Blood Volume: 123 Page(s): 3828 - 3831
    06/12/2014 Authors: Nayak L; Shi H; Atkins GB; Lin Z; Schmaier AH; Jain MK
  • Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function.
    Am J Physiol Heart Circ Physiol Volume: 304 Page(s): H796 - H805
    03/15/2013 Authors: Shi H; Sheng B; Zhang F; Wu C; Zhang R; Zhu J; Xu K; Kuang Y; Jameson SC; Lin Z
  • KLF2 Protects Against Ischemic Stroke by Regulating Endothelial Blood Brain Barrier Function
    Volume: 44
    02/01/2013 Authors: Shi H; Sheng B; Zhang F; Zhang R; Wu C; Zhu J; Jameson SC; Lin Z; Wang Y; Chen J
  • "Go with the flow": how Krppel-like factor 2 regulates the vasoprotective effects of shear stress.
    Antioxid Redox Signal Volume: 15 Page(s): 1449 - 1461
    09/01/2011 Authors: Nayak L; Lin Z; Jain MK
  • The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.
    Immunity Volume: 34 Page(s): 715 - 728
    05/27/2011 Authors: Mahabeleshwar GH; Kawanami D; Sharma N; Takami Y; Zhou G; Shi H; Nayak L; Jeyaraj D; Grealy R; White M
  • p53 impairs endothelial function by transcriptionally repressing Kruppel-Like Factor 2.
    Arterioscler Thromb Vasc Biol Volume: 31 Page(s): 133 - 141
    01/01/2011 Authors: Kumar A; Kim C-S; Hoffman TA; Naqvi A; Dericco J; Jung S-B; Lin Z; Jain MK; Irani K
  • Kruppel-like factor 2 regulates endothelial barrier function.
    Arterioscler Thromb Vasc Biol Volume: 30 Page(s): 1952 - 1959
    10/01/2010 Authors: Lin Z; Natesan V; Shi H; Dong F; Kawanami D; Mahabeleshwar GH; Atkins GB; Nayak L; Cui Y; Finigan JH
  • A novel role of CCN3 in regulating endothelial inflammation.
    J Cell Commun Signal Volume: 4 Page(s): 141 - 153
    10/01/2010 Authors: Lin Z; Natesan V; Shi H; Hamik A; Kawanami D; Hao C; Mahabaleshwar GH; Wang W; Jin Z-G; Atkins GB
  • A Novel Role of Kruppel-like Factor 2 (KLF2) in Regulating Endothelial Barrier Function
    Volume: 120 Page(s): S1013 - S1013
    11/03/2009 Authors: Lin Z; Natesan V; Shi H; Kawanami D; Hao C; Mahabaleshwar GH; Atkins GB; Finigan JH; Jain MK
  • A Novel Role of CCN3 in Regulating Endothelial Inflammation
    Volume: 120 Page(s): S1029 - S1029
    11/03/2009 Authors: Lin Z; Natesan V; Shi H; Hamik A; Kawanami D; Hao C; Mahabaleshwar GH; Atkins GB; Rittie L; Firth SM
  • Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium.
    J Biol Chem Volume: 284 Page(s): 20522 - 20530
    07/31/2009 Authors: Kawanami D; Mahabeleshwar GH; Lin Z; Atkins GB; Hamik A; Haldar SM; Maemura K; Lamanna JC; Jain MK
  • KIf2 Inhibits Hif-1 alpha Expression and Function in the Endothelium
    Volume: 118 Page(s): S550 - S550
    10/28/2008 Authors: Kawanami D; Lin Z; Mahabaleshwar G; Atkins GB; Hamik A; Haldar S; Maemura K; Lingrel J; Jain M
  • Hemizygous deficiency of Krppel-like factor 2 augments experimental atherosclerosis.
    Circ Res Volume: 103 Page(s): 690 - 693
    09/26/2008 Authors: Atkins GB; Wang Y; Mahabeleshwar GH; Shi H; Gao H; Kawanami D; Natesan V; Lin Z; Simon DI; Jain MK
  • Assessment of released acrosin activity as a measurement of the sperm acrosome reaction.
    Asian J Androl Volume: 10 Page(s): 236 - 242
    03/01/2008 Authors: Liu R-Z; Na W-L; Zhang H-G; Lin Z-Y; Xue B-G; Xu Z-G
  • Kruppel-like factor 4 regulates endothelial inflammation.
    J Biol Chem Volume: 282 Page(s): 13769 - 13779
    05/04/2007 Authors: Hamik A; Lin Z; Kumar A; Balcells M; Sinha S; Katz J; Feinberg MW; Gerzsten RE; Edelman ER; Jain MK
  • Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.
    Proc Natl Acad Sci U S A Volume: 104 Page(s): 7074 - 7079
    04/24/2007 Authors: Fisch S; Gray S; Heymans S; Haldar SM; Wang B; Pfister O; Cui L; Kumar A; Lin Z; Sen-Banerjee S
  • Kruppel-like factor 4 (KLF4) regulates endothelial inflammation
    Volume: 49 Page(s): 421A - 421A
    03/06/2007 Authors: Hamik A; Lin Z; Kumar A; Balcells M; Sinha S; Katz J; Gerzsten RE; Edelman ER; Jain MK
  • Kruppel-like factor 4 regulates endothelial inflammation.
    Volume: 55 Page(s): S355 - S356
    03/01/2007 Authors: Hamik A; Lin Z; Kumar A; Balcells M; Sinha S; Katz J; Gerzsten RE; Edelman ER; Jain MK
  • The Kruppel-like factor KLF15 is a novel regulator of cardiomyocyte hypertrophy
    Volume: 114 Page(s): 161 - 162
    10/31/2006 Authors: Fisch S; Gray SJ; Heymans S; Wang B; Haldar S; Pfister O; Cui L; Kumar A; Lin Z; Sen-Banerjee S
  • Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation.
    Arterioscler Thromb Vasc Biol Volume: 26 Page(s): 1185 - 1189
    05/01/2006 Authors: Lin Z; Hamik A; Jain R; Kumar A; Jain MK
  • Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes.
    Proc Natl Acad Sci U S A Volume: 103 Page(s): 6653 - 6658
    04/25/2006 Authors: Das H; Kumar A; Lin Z; Patino WD; Hwang PM; Feinberg MW; Majumder PK; Jain MK
  • Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.
    J Clin Invest Volume: 116 Page(s): 49 - 58
    01/01/2006 Authors: Parmar KM; Larman HB; Dai G; Zhang Y; Wang ET; Moorthy SN; Kratz JR; Lin Z; Jain MK; Gimbrone MA
  • KLF2 as a novel mediator of statin effects in endothelial cells
    Volume: 112 Page(s): U369 - U369
    10/25/2005 Authors: SenBanerjee S; Mir S; Lin ZY; Hamik A; Atkins GB; Das H; Banerjee P; Kumar A; Jain MK
  • Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2.
    J Biol Chem Volume: 280 Page(s): 28848 - 28851
    08/12/2005 Authors: Bhattacharya R; Senbanerjee S; Lin Z; Mir S; Hamik A; Wang P; Mukherjee P; Mukhopadhyay D; Jain MK
  • Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.
    Circulation Volume: 112 Page(s): 720 - 726
    08/02/2005 Authors: Sen-Banerjee S; Mir S; Lin Z; Hamik A; Atkins GB; Das H; Banerjee P; Kumar A; Jain MK
  • Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases.
    Mol Cell Biol Volume: 25 Page(s): 5893 - 5903
    07/01/2005 Authors: Kumar A; Lin Z; SenBanerjee S; Jain MK
  • Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function.
    Circ Res Volume: 96 Page(s): e48 - e57
    03/18/2005 Authors: Lin Z; Kumar A; SenBanerjee S; Staniszewski K; Parmar K; Vaughan DE; Gimbrone MA; Balasubramanian V; Garca-Cardea G; Jain MK
  • KLF15 is a novel regulator of cardiomyocyte gene expression
    Volume: 110 Page(s): 262 - 263
    10/26/2004 Authors: Fisch SM; Gray SG; SenBanerjee S; Lin ZY; Kumar A; Das H; Petersen CA; Burleigh BA; Jain MK
  • The Kruppel-like Factor 2 (KLF2) regulates endothelial thrombotic gene expression
    Volume: 110 Page(s): 317 - 317
    10/26/2004 Authors: Lin ZY; Senbanerjee S; Kumar A; Vaughan DE; Parmar K; Gimbrone MA; Garcia-Cardena G; Jain MK
  • The Kruppel-like factor KLF2 is a novel inhibitor of angiogenesis via repression of the VEGF receptor VEGFR2 (KDR/flk-1)
    Volume: 110 Page(s): 173 - 173
    10/26/2004 Authors: SenBanerjee S; Bhattacharya R; Wang P; Lin ZY; Mukhopadhyay D; Jain MK
  • TNF-alpha-mediated inhibition of kruppel-like factor 2 (KLF2) in endothelial cells involves NF-kappa B and histone deacetylases
    Volume: 110 Page(s): 191 - 191
    10/26/2004 Authors: Kumar A; Lin ZY; SenBanerjee S; Jain MK
  • An emerging role for Krppel-like factors in vascular biology.
    Trends Cardiovasc Med Volume: 14 Page(s): 241 - 246
    08/01/2004 Authors: Feinberg MW; Lin Z; Fisch S; Jain MK
  • KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.
    J Exp Med Volume: 199 Page(s): 1305 - 1315
    05/17/2004 Authors: SenBanerjee S; Lin Z; Atkins GB; Greif DM; Rao RM; Kumar A; Feinberg MW; Chen Z; Simon DI; Luscinskas FW
  • KLF2 as a novel transcriptional regulator of endothelial cell function
    Volume: 108 Page(s): 169 - 169
    10/28/2003 Authors: SenBanerjee S; Lin ZY; Atkins GB; Greif DM; Rao RM; Feinberg MW; Chen ZP; Simon DI; Luscinskas FW; Michel TM
  • Zona pellucida-induced acrosome reaction in human sperm: dependency on activation of pertussis toxin-sensitive G(i) protein and extracellular calcium, and priming effect of progesterone and follicular fluid.
    Mol Hum Reprod Volume: 8 Page(s): 722 - 727
    08/01/2002 Authors: Schuffner AA; Bastiaan HS; Duran HE; Lin Z-Y; Morshedi M; Franken DR; Oehninger S
  • Characterization of the biologic activities of a recombinant human zona pellucida protein 3 expressed in human ovarian teratocarcinoma (PA-1) cells.
    Am J Obstet Gynecol Volume: 184 Page(s): 835 - 843
    04/01/2001 Authors: Dong KW; Chi TF; Juan YW; Chen CW; Lin Z; Xiang XQ; Mahony M; Gibbons WE; Oehninger S
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