Publications

• Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP.
  Adv Sci (Weinh) Volume: 12 Page(s): e2407494
  03/01/2025 Authors: Cui X; Zhu Y; Zeng L; Zhang M; Uddin A; Gillespie TW; McCullough LE; Zhao S; Torres MA; Wan Y
• Tuning Immune-Cold Tumor by Suppressing USP10/B7-H4 Proteolytic Axis Reinvigorates Therapeutic Efficacy of ADCs.
  Adv Sci (Weinh) Volume: 11 Page(s): e2400757
  10/01/2024 Authors: Zeng L; Zhu Y; Cui X; Chi J; Uddin A; Zhou Z; Song X; Dai M; Cristofanilli M; Kalinsky K
• Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers.
  J Clin Invest Volume: 134
  03/26/2024 Authors: Zhu Y; Banerjee A; Xie P; Ivanov AA; Uddin A; Jiao Q; Chi JJ; Zeng L; Lee JY; Xue Y
• New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy.
  Semin Cancer Biol Volume: 90 Page(s): 29 - 44
  05/01/2023 Authors: Zeng L; Zhu Y; Moreno CS; Wan Y
• Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
  Sci Adv Volume: 9 Page(s): eadd6626
  01/06/2023 Authors: Fu Z; Chen S; Zhu Y; Zhang D; Xie P; Jiao Q; Chi J; Xu S; Xue Y; Lu X
• MnSOD Lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondrial metabolism.
  Int J Biol Sci Volume: 17 Page(s): 1203 - 1216
  01/01/2021 Authors: Gao Y; Zhu Y; Tran EL; Tokars V; Dean AE; Quan S; Gius D
• SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.
  Proc Natl Acad Sci U S A Volume: 116 Page(s): 23534 - 23541
  11/19/2019 Authors: He C; Danes JM; Hart PC; Zhu Y; Huang Y; de Abreu AL; O'Brien J; Mathison AJ; Tang B; Frasor JM
• Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter.
  Nat Commun Volume: 10 Page(s): 2399
  06/03/2019 Authors: Zhu Y; Zou X; Dean AE; Brien JO; Gao Y; Tran EL; Park S-H; Liu G; Kieffer MB; Jiang H
• Homeostatic Roles of STING in Cell Proliferation and Chromosomal Instability.
  Cancer Res Volume: 79 Page(s): 1295 - 1296
  04/01/2019 Authors: Gius D; Zhu Y
• Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy.
  J Clin Invest Volume: 128 Page(s): 3682 - 3691
  08/31/2018 Authors: Zhu Y; Dean AE; Horikoshi N; Heer C; Spitz DR; Gius D
• Glycogen Phosphorylase: A Novel Biomarker in Doxorubicin-Induced Cardiac Injury.
  Clin Cancer Res Volume: 24 Page(s): 1516 - 1517
  04/01/2018 Authors: Zhu Y; Gius D
• Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?
  J Bioenerg Biomembr Volume: 49 Page(s): 325 - 333
  08/01/2017 Authors: Zou X; Ratti BA; O'Brien JG; Lautenschlager SO; Gius DR; Bonini MG; Zhu Y
• SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth.
  Cancer Res Volume: 77 Page(s): 3990 - 3999
  08/01/2017 Authors: Zou X; Zhu Y; Park S-H; Liu G; O'Brien J; Jiang H; Gius D
• Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
  Antioxid Redox Signal Volume: 26 Page(s): 849 - 863
  05/20/2017 Authors: Liu G; Park S-H; Imbesi M; Nathan WJ; Zou X; Zhu Y; Jiang H; Parisiadou L; Gius D
• Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis.
  Aging (Albany NY) Volume: 9 Page(s): 627 - 649
  03/26/2017 Authors: Uzhachenko R; Boyd K; Olivares-Villagomez D; Zhu Y; Goodwin JS; Rana T; Shanker A; Tan WJT; Bondar T; Medzhitov R
• Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism.
  Radiat Res Volume: 186 Page(s): 385 - 395
  10/01/2016 Authors: Rodman SN; Spence JM; Ronnfeldt TJ; Zhu Y; Solst SR; O'Neill RA; Allen BG; Guan X; Spitz DR; Fath MA
• Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype.
  Antioxid Redox Signal Volume: 25 Page(s): 326 - 336
  08/20/2016 Authors: Zou X; Santa-Maria CA; O'Brien J; Gius D; Zhu Y
• SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.
  Cancer Res Volume: 76 Page(s): 3802 - 3812
  07/01/2016 Authors: Park S-H; Ozden O; Liu G; Song HY; Zhu Y; Yan Y; Zou X; Kang H-J; Jiang H; Principe DR
• The Makes Caterpillars Floppy (MCF)-Like Domain of Vibrio vulnificus Induces Mitochondrion-Mediated Apoptosis.
  Infect Immun Volume: 83 Page(s): 4392 - 4403
  11/01/2015 Authors: Agarwal S; Zhu Y; Gius DR; Satchell KJF
• Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma.
  Surgery Volume: 158 Page(s): 827 - 836
  09/01/2015 Authors: Zhu Y; Paul P; Lee S; Craig BT; Rellinger EJ; Qiao J; Gius DR; Chung DH
• Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain.
  Nat Commun Volume: 6 Page(s): 7396
  06/08/2015 Authors: Antic I; Biancucci M; Zhu Y; Gius DR; Satchell KJF
• SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.
  Free Radic Biol Med Volume: 76 Page(s): 163 - 172
  11/01/2014 Authors: Ozden O; Park S-H; Wagner BA; Song HY; Zhu Y; Vassilopoulos A; Jung B; Buettner GR; Gius D
• Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population.
  Redox Biol Volume: 2 Page(s): 847 - 854
  01/01/2014 Authors: Wegman-Points LJ; Teoh-Fitzgerald MLT; Mao G; Zhu Y; Fath MA; Spitz DR; Domann FE
• Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes.
  Free Radic Biol Med Volume: 65 Page(s): 70 - 77
  12/01/2013 Authors: Xiao W; Zhu Y; Sarsour EH; Kalen AL; Aykin-Burns N; Spitz DR; Goswami PC
• A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11).
  Toxicol Sci Volume: 136 Page(s): 39 - 50
  11/01/2013 Authors: Zhu Y; Mapuskar KA; Marek RF; Xu W; Lehmler H-J; Robertson LW; Hornbuckle KC; Spitz DR; Aykin-Burns N
• Metabolic regulation of Sirtuins upon fasting and the implication for cancer.
  Curr Opin Oncol Volume: 25 Page(s): 630 - 636
  11/01/2013 Authors: Zhu Y; Yan Y; Gius DR; Vassilopoulos A
• Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity.
  Free Radic Biol Med Volume: 53 Page(s): 828 - 833
  08/15/2012 Authors: Zhu Y; Park S-H; Ozden O; Kim H-S; Jiang H; Vassilopoulos A; Spitz DR; Gius D
• Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.
  Cancer Res Volume: 71 Page(s): 3932 - 3940
  06/01/2011 Authors: Orcutt KP; Parsons AD; Sibenaller ZA; Scarbrough PM; Zhu Y; Sobhakumari A; Wilke WW; Kalen AL; Goswami P; Miller FJ
• Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.
  Free Radic Biol Med Volume: 49 Page(s): 976 - 983
  09/15/2010 Authors: Tan M; Zhu Y; Kovacev J; Zhao Y; Pan Z-Q; Spitz DR; Sun Y
• Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.
  Free Radic Biol Med Volume: 48 Page(s): 1024 - 1033
  04/15/2010 Authors: Hadzic T; Aykin-Burns N; Zhu Y; Coleman MC; Leick K; Jacobson GM; Spitz DR
• Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure.
  Free Radic Biol Med Volume: 47 Page(s): 1762 - 1771
  12/15/2009 Authors: Zhu Y; Kalen AL; Li L; Lehmler H-J; Robertson LW; Goswami PC; Spitz DR; Aykin-Burns N
• Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation.
  Radiat Res Volume: 172 Page(s): 737 - 745
  12/01/2009 Authors: Dayal D; Martin SM; Owens KM; Aykin-Burns N; Zhu Y; Boominathan A; Pain D; Limoli CL; Goswami PC; Domann FE
• Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation.
  Biochem J Volume: 418 Page(s): 29 - 37
  02/15/2009 Authors: Aykin-Burns N; Ahmad IM; Zhu Y; Oberley LW; Spitz DR