Young Yoon MD/PhD
Overview
Dr. Yoon is Professor of Medicine and Biomedical Engineering, and Director of Stem Cell Biology at Emory University School of Medicine in Atlanta, Georgia. Dr. Yoons research focus is cardiovascular regeneration with stem cells and bioengineering.
Dr. Yoon published more than 100 papers in high profile journals including Nature Medicine, JCI, Circulation, Circulation Research, JACC, and ACS Nano. Dr. Yoon received many awards over the past decade. Dr. Yoon was a finalist in both AHA and ACC Young Investigator Awards. Dr. Yoon is Fellow of AHA, a chartered member of NIH study section, and a member of editorial boards of Circulation Research, Regenerative Medicine, PLOS One, and others. He also received several awards from Emory University including Faculty Excellence in 2014, Innovation of 2012 Award, and Outstanding Basic Research Citation Award in 2011. He was also elected as prestigious member of American Society for Clinical Investigation as the first Korean medical school graduates.
The goal of his laboratory is to develop a strategy for regenerating cardiovascular diseases using stem cells and tissue engineering technologies. Dr. Yoons laboratory has focused on generating stem or progenitor cells including induced pluripotent stem cells, multipotent bone marrow cells, and angio-vasculogenic cells, and developing various methods to differentiate these cells into endothelial cells and cardiomyocytes. His laboratory investigates their therapeutic utility in cardiovascular diseases such as peripheral vascular disease including diabetic complications, myocardial infarction, lymphedema and diabetic neuropathy. Mechanistically, the research focuses on angiogenesis, vasculogenesis, lymphangiogenesis and cardiomyogenesis. Recently, his research is extended into bioengineering of stem cells, reprogramming of somatic cells into target cells and restoring the function of damaged stem or progenitor cells by epigenetic modifications.
Academic Appointment
- Professor of Medicine, Emory University School of Medicine
Education
Degrees
- PhD from Yonsei University
- M.S. from Yonsei University
- MD from Yonsei University
- pre-medicine from Yonsei University
Research
Focus
- My Lab has focused on developing stem or progenitor cells and investigating their therapeutic utility in various cardiovascular diseases such as myocardial infarction, heart failure, peripheral vascular ischemia, lymphedema diabetic neuropathy. Mechanistically, we have strong interest in angiogenesis, vasculogenesis, cardiomyogenesis and lymphangiogenesis. We recently have studied reprogramming of somatic cells into pluripotent stem cells and cardiomyocytes, and investigating the mechanisms.
Publications
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Novel Directly Reprogrammed Smooth Muscle Cells Promote Vascular Regeneration as Microvascular Mural Cells.
Circulation Volume: 151 Page(s): 1076 - 1094
04/15/2025 Authors: Jung C; Han JW; Lee S-J; Kim KH; Oh JE; Bae S; Lee S; Nam Y-J; Kim S; Dang C -
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18.
Nat Biomed Eng Volume: 8 Page(s): 1124 - 1141
09/01/2024 Authors: Wolfson DW; Kim NK; Lee KH; Beyersdorf JP; Langberg JJ; Fernandez N; Choi D; Zureick N; Kim TY; Bae S -
Generation of Directly Reprogrammed Human Endothelial Cells.
Methods Mol Biol Volume: 2835 Page(s): 155 - 164
01/01/2024 Authors: Cho S; Xia I; Lee S; Park C; Yoon Y-S -
The role of paracrine crosstalk between myeloid and endothelial cells in myocardial angiogenesis and infarcted heart repair.
J Cardiovasc Aging Volume: 3
01/01/2023 Authors: Cho K-W; Bae S; Yoon Y-S -
Generation and Application of Directly Reprogrammed Endothelial Cells.
Korean Circ J Volume: 52 Page(s): 643 - 658
09/01/2022 Authors: Jung C; Oh JE; Lee S; Yoon Y-S -
Risk Factors for Recurrence in Pancreatic Neuroendocrine Tumor and Size as a Surrogate in Determining the Treatment Strategy: A Korean Nationwide Study.
Neuroendocrinology Volume: 111 Page(s): 794 - 804
01/01/2021 Authors: Kwon W; Jang J-Y; Song KB; Hwang DW; Kim SC; Heo JS; Choi DW; Hwang HK; Kang CM; Yoon Y-S -
Therapeutic Effects of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells Encapsulated within Modified-Hyaluronic Acid Hydrogel in Ischemic Tissues
Volume: 28 Page(s): 363 - 363
04/28/2020 Authors: Park M; Kim S; Shin J; Kim J; Lee S-J; Cho S-W; Yoon Y-S -
New Approach for Directly Reprogrammed Endothelial Cells
Volume: 125
08/02/2019 Authors: Lee S; Chen D; Yoon Y-S -
Enhanced Neovascularization by ETV2 via Angiogenesis in Myocardial Infarction Models
Volume: 125
08/02/2019 Authors: Bae S-H; Lee S; Kim S; Yoon Y-S -
Therapeutic Effects of Engineered Human Pluripotent Stem Cell-derived Lymphatic Endothelial Cells on Experimental Lymphedema
Volume: 125
08/02/2019 Authors: Lee S-J; Sohn Y-D; Sung E-A; Kim J; Yoon Y-S