Ya Wang PhD

Department of Radiation Oncology
Professor

(404) 778-1832
ywang94@emory.edu

Academic Appointment

Professor of Division of Experimental Radiation Oncology, Department of Radiation Oncology, Emory University School of Medicine

Education

Degrees

PhD from Academy of Medical Science
No Degree from The Third Medicine University
MD from The Third Medicine University

Research

Focus

DNA damage responses including DNA repair, checkpoint activation and cancer-genesis.

Publications

Corrigendum to "Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J" [DNA Repair9 (2010) 1170-1175].
DNA Repair (Amst) Volume: 134 Page(s): 103631
02/01/2024 Authors: Ng WL; Yan D; Zhang X; Mo Y-Y; Wang Y
Retraction Note: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation.
Cell Death Dis Volume: 13 Page(s): 219
03/09/2022 Authors: Ng WL; Chen G; Wang M; Wang H; Story M; Shay JW; Zhang X; Wang J; Amin ARMR; Hu B
RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3 Co-localization.
Cell Rep Volume: 34 Page(s): 108625
01/12/2021 Authors: Wang J; Oh Y-T; Li Z; Dou J; Tang S; Wang X; Wang H; Takeda S; Wang Y
Corrigendum to "The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation" [DNA Repair 27 (2008) 725-733].
DNA Repair (Amst) Volume: 95 Page(s): 102857
11/01/2020 Authors: Wang H; Wang X; Zhang P; Wang Y
A potential new role of ATM inhibitor in radiotherapy: suppressing ionizing Radiation-Activated EGFR.
Int J Radiat Biol Volume: 96 Page(s): 461 - 468
04/01/2020 Authors: Tang S; Li Z; Yang L; Shen L; Wang Y
MRI-based Proton Radiotherapy for Prostate Cancer Using Deep Convolutional Neural Networks
Volume: 105 Page(s): S200 - S200
09/01/2019 Authors: Yang X; Liu Y; Lei Y; Wang Y; Shafai-Erfani G; Wang T; Tian S; Patel PR; Jani A; Curran WJ
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.
Sci Rep Volume: 9 Page(s): 12546
08/29/2019 Authors: Werner E; Alter A; Deng Q; Dammer EB; Wang Y; Yu DS; Duong DM; Seyfried NT; Doetsch PW
DNA-PKCS deacetylation by SIRT2 promotes DNA double-strand break repair by non-homologous end joining
CANCER RESEARCH Volume: 79
07/01/2019 Authors: Head PE; Ganji NP; Wang S-Y; Duong D; Zhang H; Daddacha W; Li S; Seyfried NT; Smalley DM; Wang Y
Ionizing radiation-induced growth in soft agar is associated with miR-21 upregulation in wild-type and DNA double strand break repair deficient cells.
DNA Repair (Amst) Volume: 78 Page(s): 37 - 44
06/01/2019 Authors: Tang S; Liu B; Liu M; Li Z; Liu J; Wang H; Wang J; Oh Y-T; Shen L; Wang Y
A protein-mRNA feedback exists in miR-21-associated E-selectin expression.
Int J Radiat Biol Volume: 95 Page(s): 580 - 584
05/01/2019 Authors: Tang S; Liu B; Liu J; Wang J; Wang Y
Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells.
Sci Rep Volume: 8 Page(s): 11038
07/23/2018 Authors: Li Z; Jella KK; Jaafar L; Li S; Park S; Story MD; Wang H; Wang Y; Dynan WS
Targeting a Novel Function for SAMHD1 in DNA Repair for Radiation Therapy and PARP Inhibition
Volume: 127 Page(s): S192 - S193
04/01/2018 Authors: Yu D; Daddacha W; Koyen A; Bastien A; Head P; Dhere V; Nabeta G; Connolly E; Werner E; Madden M
Progesterone improves neurocognitive outcomes following therapeutic cranial irradiation in mice.
Horm Behav Volume: 96 Page(s): 21 - 30
11/01/2017 Authors: Yousuf S; Brat DJ; Shu H-K; Wang Y; Stein DG; Atif F
A Single Exposure to Low- or High-LET Radiation Induces Persistent Genomic Damage in Mouse Epithelial Cells In Vitro and in Lung Tissue.
Radiat Res Volume: 188 Page(s): 373 - 380
10/01/2017 Authors: Werner E; Wang Y; Doetsch PW
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Cell Rep Volume: 20 Page(s): 1921 - 1935
08/22/2017 Authors: Daddacha W; Koyen AE; Bastien AJ; Head PE; Dhere VR; Nabeta GN; Connolly EC; Werner E; Madden MZ; Daly MB
Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients.
Oncotarget Volume: 8 Page(s): 22842 - 22853
04/04/2017 Authors: Wu R; Liu T; Yang P; Liu X; Liu F; Wang Y; Xiong H; Yu S; Huang X; Zhuang L
N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2.
ACS Chem Neurosci Volume: 8 Page(s): 548 - 557
03/15/2017 Authors: Wang Y; Plastina P; Vincken J-P; Jansen R; Balvers M; Ten Klooster JP; Gruppen H; Witkamp R; Meijerink J
miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.
J Biol Chem Volume: 292 Page(s): 3531 - 3540
02/24/2017 Authors: Hu B; Wang X; Hu S; Ying X; Wang P; Zhang X; Wang J; Wang H; Wang Y
Tumor Penetrating Theranostic Nanoparticles for Enhancement of Targeted and Image-guided Drug Delivery into Peritoneal Tumors following Intraperitoneal Delivery.
Theranostics Volume: 7 Page(s): 1689 - 1704
01/01/2017 Authors: Gao N; Bozeman EN; Qian W; Wang L; Chen H; Lipowska M; Staley CA; Wang YA; Mao H; Yang L
DNA repair pathway choice at various conditions immediately post irradiation.
Int J Radiat Biol Volume: 92 Page(s): 819 - 822
12/01/2016 Authors: Liu M; Wang H; Lee S; Liu B; Dong L; Wang Y
GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis.
Nat Commun Volume: 7 Page(s): 11795
06/08/2016 Authors: Wang J; Farris AB; Xu K; Wang P; Zhang X; Duong DM; Yi H; Shu H-K; Sun S-Y; Wang Y
Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments.
Life Sci Space Res (Amst) Volume: 9 Page(s): 48 - 55
06/01/2016 Authors: Wang J; Zhang X; Wang P; Wang X; Farris AB; Wang Y
The Associations Between the Polymorphisms of Vitamin D Receptor and Coronary Artery Disease: A Systematic Review and Meta-Analysis.
Medicine (Baltimore) Volume: 95 Page(s): e3467
05/01/2016 Authors: Lu S; Guo S; Hu F; Guo Y; Yan L; Ma W; Wang Y; Wei Y; Zhang Z; Wang Z
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
Cell Rep Volume: 14 Page(s): 1435 - 1447
02/16/2016 Authors: Zhang H; Head PE; Daddacha W; Park S-H; Li X; Pan Y; Madden MZ; Duong DM; Xie M; Yu B
Systematic study of cis-antisense miRNAs in animal species reveals miR-3661 to target PPP2CA in human cells.
RNA Volume: 22 Page(s): 87 - 95
01/01/2016 Authors: Wang J; Li Z; Liu B; Chen G; Shao N; Ying X; Wang Y
MRI localization of the subthalamic nucleus in normal adults and its relation with age.
Neuroreport Volume: 26 Page(s): 972 - 980
11/11/2015 Authors: Lv H; Geng Z; Zhu Q; Wang L; Song Z; Chang R; Wang Y
Radiation activated CHK1/MEPE pathway may contribute to microgravity-induced bone density loss.
Life Sci Space Res (Amst) Volume: 7 Page(s): 53 - 56
11/01/2015 Authors: Zhang X; Wang P; Wang Y
Co-culturing with High-Charge and Energy Particle Irradiated Cells Increases Mutagenic Joining of Enzymatically Induced DNA Double-Strand Breaks in Nonirradiated Cells.
Radiat Res Volume: 184 Page(s): 249 - 258
09/01/2015 Authors: Li Z; Doho G; Zheng X; Jella KK; Li S; Wang Y; Dynan WS
Concepts and challenges in cancer risk prediction for the space radiation environment.
Life Sci Space Res (Amst) Volume: 6 Page(s): 92 - 103
07/01/2015 Authors: Barcellos-Hoff MH; Blakely EA; Burma S; Fornace AJ; Gerson S; Hlatky L; Kirsch DG; Luderer U; Shay J; Wang Y
Short-term, daily exposure to cold temperature may be an efficient way to prevent muscle atrophy and bone loss in a microgravity environment.
Life Sci Space Res (Amst) Volume: 5 Page(s): 1 - 5
04/01/2015 Authors: Deng C; Wang P; Zhang X; Wang Y
DICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27.
Nucleic Acids Res Volume: 43 Page(s): 1626 - 1636
02/18/2015 Authors: Liu B; Liu M; Wang J; Zhang X; Wang X; Wang P; Wang H; Li W; Wang Y
Relative effectiveness at 1 gy after acute and fractionated exposures of heavy ions with different linear energy transfer for lung tumorigenesis.
Radiat Res Volume: 183 Page(s): 233 - 239
02/01/2015 Authors: Wang X; Farris Iii AB; Wang P; Zhang X; Wang H; Wang Y
Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation.
Nucleic Acids Res Volume: 43 Page(s): 960 - 972
01/01/2015 Authors: Xie M; Park D; You S; Li R; Owonikoko TK; Wang Y; Doetsch PW; Deng X
Ku-dependent non-homologous end-joining as the major pathway contributes to sublethal damage repair in mammalian cells.
Int J Radiat Biol Volume: 91 Page(s): 867 - 871
01/01/2015 Authors: Liu M; Lee S; Liu B; Wang H; Dong L; Wang Y
Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells.
Radiat Res Volume: 182 Page(s): 573 - 579
11/01/2014 Authors: Li Z; Wang H; Wang Y; Murnane JP; Dynan WS
Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing.
J Biol Chem Volume: 289 Page(s): 30635 - 30644
10/31/2014 Authors: Wang H; Wang X; Chen G; Zhang X; Tang X; Park D; Cucinotta FA; Yu DS; Deng X; Dynan WS
Heavier ions with a different linear energy transfer spectrum kill more cells due to similar interference with the Ku-dependent DNA repair pathway.
Radiat Res Volume: 182 Page(s): 458 - 461
10/01/2014 Authors: Wang H; Wang Y
A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response.
Nucleic Acids Res Volume: 42 Page(s): 11517 - 11527
10/01/2014 Authors: Smith SC; Petrova AV; Madden MZ; Wang H; Pan Y; Warren MD; Hardy CW; Liang D; Liu EA; Robinson MH
Integration of MR Images Into Ultrasound for 3D Doppler Imaging of the Neurovascular Bundle in Prostate Radiation Therapy: A Pilot Study
Volume: 90 Page(s): S440 - S440
09/01/2014 Authors: Yang X; Rossi PJ; Ogunleye TB; Wang Y; Curran WJ; Liu T
Nit1 Is a Novel Therapeutic Target for the Sensitization of Chemo- and Radiation Therapy in KRAS Mutant Lung Cancer Models
Volume: 90 Page(s): S805 - S805
09/01/2014 Authors: Sun Y; Wang Y; Tao Z; LeBlanc J; Myers CJ; Dicker AP; Lu B
Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis.
Cell Death Differ Volume: 21 Page(s): 1160 - 1169
07/01/2014 Authors: Wang B; Xie M; Li R; Owonikoko TK; Ramalingam SS; Khuri FR; Curran WJ; Wang Y; Deng X
Identification of a tumor-suppressive human-specific microRNA within the FHIT tumor-suppressor gene.
Cancer Res Volume: 74 Page(s): 2283 - 2294
04/15/2014 Authors: Hu B; Ying X; Wang J; Piriyapongsa J; Jordan IK; Sheng J; Yu F; Zhao P; Li Y; Wang H
OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation.
Cell Death Dis Volume: 5 Page(s): e1024
01/23/2014 Authors: Ng WL; Chen G; Wang M; Wang H; Story M; Shay JW; Zhang X; Wang J; Amin ARMR; Hu B
Influence of Vascular Comorbidities and Race on Erectile Dysfunction After Prostate Cancer Radiation Therapy
Volume: 87 Page(s): S371 - S371
10/01/2013 Authors: Wang Y; Tian L; Rossi P; Watkins-Bruner D; Hsiao W; Cooper S; Yang X; Jani A
Acute Toxicity Can Be Used to Predict Late Toxicity in Breast-Cancer Radiation Therapy: A Prospective Longitudinal Study With Quantitative Ultrasound Imaging
Volume: 87 Page(s): S237 - S238
10/01/2013 Authors: Liu T; Yang X; Liu Y; Wang Y; Curran WJ; Torres MA
Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells.
Radiat Res Volume: 180 Page(s): 17 - 24
07/01/2013 Authors: Li Z; Hudson FZ; Wang H; Wang Y; Bian Z; Murnane JP; Dynan WS
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.
J Biol Chem Volume: 288 Page(s): 13215 - 13224
05/10/2013 Authors: Li Y; Wang X; Yue P; Tao H; Ramalingam SS; Owonikoko TK; Deng X; Wang Y; Fu H; Khuri FR
Multiphasic contrast-enhanced MRI: single-slice versus volumetric quantification of tumor enhancement for the assessment of renal clear-cell carcinoma fuhrman grade.
J Magn Reson Imaging Volume: 37 Page(s): 1160 - 1167
05/01/2013 Authors: Vargas HA; Delaney HG; Delappe EM; Wang Y; Zheng J; Moskowitz CS; Tan Y; Zhao B; Schwartz LH; Hricak H
A dominant major locus in chromosome 9 of rice (Oryza sativa L.) confers tolerance to 48C high temperature at seedling stage.
J Hered Volume: 104 Page(s): 287 - 294
03/01/2013 Authors: Wei H; Liu J; Wang Y; Huang N; Zhang X; Wang L; Zhang J; Tu J; Zhong X
Combining heavy ion radiation and artificial microRNAs to target the homologous recombination repair gene efficiently kills human tumor cells.
Int J Radiat Oncol Biol Phys Volume: 85 Page(s): 466 - 471
02/01/2013 Authors: Zheng Z; Wang P; Wang H; Zhang X; Wang M; Cucinotta FA; Wang Y
Using Mathematical Modeling to Specify Treatment Margins for Prostate Cancer May Reduce Radiation Dose to Bladder and Rectum
Volume: 84 Page(s): S82 - S82
11/01/2012 Authors: Howard ME; Khan M; Miller L; Wang Y; Underwood R; Liu T; Yang X; Yang W
Prostate Motion Is Correlated in the Superior/Inferior (SI) and Anterior/Posterior (AP) Direction: Use Statistical Margin Recipes With Extreme Caution
Volume: 84 Page(s): S776 - S776
11/01/2012 Authors: Khan MK; Yang W; Yang X; Wang Y; Howard ME; Underwood RJ; Liu T
MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNF.
Cancer Res Volume: 72 Page(s): 4707 - 4713
09/15/2012 Authors: Zhang X; Ng W-L; Wang P; Tian L; Werner E; Wang H; Doetsch P; Wang Y
Surface dose investigation of the flattening filter-free photon beams.
Int J Radiat Oncol Biol Phys Volume: 83 Page(s): e281 - e285
06/01/2012 Authors: Wang Y; Khan MK; Ting JY; Easterling SB
Targeting both non-coding and coding sequences with small RNA efficiently knocks down DNA repair genes and radiosensitizes human tumor cells
CANCER RESEARCH Volume: 72
04/15/2012 Authors: Zheng Z; Wang Y; Zhang X
Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases.
Int J Radiat Oncol Biol Phys Volume: 82 Page(s): 1837 - 1844
04/01/2012 Authors: Shukla-Dave A; Lee NY; Jansen JFA; Thaler HT; Stambuk HE; Fury MG; Patel SG; Moreira AL; Sherman E; Karimi S
RNAi-mediated targeting of noncoding and coding sequences in DNA repair gene messages efficiently radiosensitizes human tumor cells.
Cancer Res Volume: 72 Page(s): 1221 - 1228
03/01/2012 Authors: Zheng Z; Ng WL; Zhang X; Olson JJ; Hao C; Curran WJ; Wang Y
Tumor metabolism and perfusion in head and neck squamous cell carcinoma: pretreatment multimodality imaging with 1H magnetic resonance spectroscopy, dynamic contrast-enhanced MRI, and [18F]FDG-PET.
Int J Radiat Oncol Biol Phys Volume: 82 Page(s): 299 - 307
01/01/2012 Authors: Jansen JFA; Schder H; Lee NY; Stambuk HE; Wang Y; Fury MG; Patel SG; Pfister DG; Shah JP; Koutcher JA
MiR-21 is continually elevated long-term in the brain after exposure to ionizing radiation.
Radiat Res Volume: 177 Page(s): 124 - 128
01/01/2012 Authors: Shi Y; Zhang X; Tang X; Wang P; Wang H; Wang Y
A stochastic model of DNA fragments rejoining.
PLoS One Volume: 7 Page(s): e44293
01/01/2012 Authors: Li Y; Qian H; Wang Y; Cucinotta FA
Analysis of inhibition of DNA replication in irradiated cells using the SV40 based in vitro assay of DNA replication.
Methods Mol Biol Volume: 920 Page(s): 591 - 602
01/01/2012 Authors: Iliakis G; Mladenov E; Wang Y; Wang HY
Radiosensitizing effects of ectopic miR-101 on non-small-cell lung cancer cells depend on the endogenous miR-101 level.
Int J Radiat Oncol Biol Phys Volume: 81 Page(s): 1524 - 1529
12/01/2011 Authors: Chen S; Wang H; Ng WL; Curran WJ; Wang Y
Identifying the key domain of CHK1 interaction with MEPE/OF45 and the key ubiquitination site of CHK1
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Chen G; Yan D; Wang Y
Ku-dependent non-homologous end-joining interferes the efficiency of Mre11 binding to replication related DNA double strand breaks
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Wang H; Zhang X; Wang Y
Solid dispersion and effervescent techniques used to prepare docetaxel liposomes for lung-targeted delivery system: in vitro and in vivo evaluation.
J Drug Target Volume: 19 Page(s): 171 - 178
04/01/2011 Authors: Zhao L; Wei Y; Li W; Liu Y; Wang Y; Zhong X; Yu Y
The Ku-dependent non-homologous end-joining pathway contributes to low-dose radiation-stimulated cell survival.
J Cell Physiol Volume: 226 Page(s): 369 - 374
02/01/2011 Authors: Yu X; Wang H; Wang P; Chen BPC; Wang Y
Effect of MicroRNA-155 on EGFRvIII Mediated Radiation Response in Glioblastoma Tumors
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS Volume: 81 Page(s): S713 - S713
01/01/2011 Authors: Wang H; Wang Y; Kaluzova M; Tang X; Yin Q; Flemington EK; Hadjipanayis CG
Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J.
DNA Repair (Amst) Volume: 9 Page(s): 1170 - 1175
11/10/2010 Authors: Ng WL; Yan D; Zhang X; Mo Y-Y; Wang Y
MicroRNA-21 is involved in ionizing radiation-promoted liver carcinogenesis.
Int J Clin Exp Med Volume: 3 Page(s): 211 - 222
07/31/2010 Authors: Zhu Y; Yu X; Fu H; Wang H; Wang P; Zheng X; Wang Y
Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation.
PLoS One Volume: 5 Page(s): e11397
07/01/2010 Authors: Yan D; Ng WL; Zhang X; Wang P; Zhang Z; Mo Y-Y; Mao H; Hao C; Olson JJ; Curran WJ
Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-PgammaMPS copolymer coating.
Biomaterials Volume: 31 Page(s): 5397 - 5407
07/01/2010 Authors: Chen H; Wang L; Yeh J; Wu X; Cao Z; Wang YA; Zhang M; Yang L; Mao H
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.
Nucleic Acids Res Volume: 38 Page(s): 3245 - 3251
06/01/2010 Authors: Wang H; Zhang X; Wang P; Yu X; Essers J; Chen D; Kanaar R; Takeda S; Wang Y
A small peptide mimicking the key domain of MEPE/OF45 interacting with CHK1 protects human cells from radiation-induced killing.
Cell Cycle Volume: 9 Page(s): 1981 - 1985
05/15/2010 Authors: Yu X; Wang H; Liu S; Zhang X; Guida P; Hu B; Wang Y
MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers.
Br J Cancer Volume: 102 Page(s): 862 - 866
03/02/2010 Authors: Zhang P; Wang H; Rowe PSN; Hu B; Wang Y
HIV-1 Tat regulates cyclin B1 by promoting both expression and degradation.
FASEB J Volume: 24 Page(s): 495 - 503
02/01/2010 Authors: Zhang S-M; Sun Y; Fan R; Xu Q-Z; Liu X-D; Zhang X; Wang Y; Zhou P-K
Targeting DNA-PK and ATM with miR-101 Sensitizes Tumors to Radiation
Volume: 78 Page(s): S631 - S632
01/01/2010 Authors: Wang Y
MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1.
Nucleic Acids Res Volume: 37 Page(s): 7447 - 7454
12/01/2009 Authors: Liu S; Wang H; Wang X; Lu L; Gao N; Rowe PSN; Hu B; Wang Y
The effects of Fhit on tumorigenesis after multi-exposure to low-dose radiation.
Int J Clin Exp Med Volume: 2 Page(s): 348 - 353
11/22/2009 Authors: Yu X; Lu L; Wen S; Wang Y
S-phase cells are more sensitive to high-linear energy transfer radiation.
Int J Radiat Oncol Biol Phys Volume: 74 Page(s): 1236 - 1241
07/15/2009 Authors: Wang H; Liu S; Zhang P; Zhang S; Naidu M; Wang H; Wang Y
Low dose radiation-induced adaptive response preventing HPRT mutation is Fhit independent.
Int J Radiat Biol Volume: 85 Page(s): 532 - 537
06/01/2009 Authors: Lu L; Hu B; Yu F; Wang Y
Enhancing sensitization of S-phase cells to high-linear energy transfer radiation by inhibition of homologous recombination repair.
Cell Cycle Volume: 8 Page(s): 1451 - 1452
05/01/2009 Authors: Wang H; Wang Y
Checkpoint response plays a more protective role in HZE particle-irradiated cells than in X ray-irradiated cells.
Cell Cycle Volume: 7 Page(s): 2444 - 2445
08/01/2008 Authors: Wang H; Wang Y
Molecular parameters of genome instability: roles of fragile genes at common fragile sites.
J Cell Biochem Volume: 104 Page(s): 1525 - 1533
08/01/2008 Authors: Pichiorri F; Ishii H; Okumura H; Trapasso F; Wang Y; Huebner K
The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation.
DNA Repair (Amst) Volume: 7 Page(s): 725 - 733
05/03/2008 Authors: Wang H; Wang X; Zhang P; Wang Y
Immunoprecipitation alert: DNA binding proteins directly bind to protein A/G without any antibody as the bridge.
Cell Cycle Volume: 7 Page(s): 417 - 418
02/01/2008 Authors: Lu L; Wang Y
A Fhit-ing role in the DNA damage checkpoint response.
Cell Cycle Volume: 6 Page(s): 1044 - 1048
05/02/2007 Authors: Ishii H; Wang Y; Huebner K
A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP-1.
Cell Cycle Volume: 5 Page(s): 2364 - 2370
10/01/2006 Authors: Lu H-R; Wang X; Wang Y
The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining.
Oncogene Volume: 25 Page(s): 1980 - 1983
03/23/2006 Authors: Wang X; Hu B; Weiss RS; Wang Y
Fhit and CHK1 have opposing effects on homologous recombination repair.
Cancer Res Volume: 65 Page(s): 8613 - 8616
10/01/2005 Authors: Hu B; Wang H; Wang X; Lu H-R; Huang C; Powell SN; Huebner K; Wang Y
CHK1 affects cell sensitivity to microtubule-targeted drugs.
J Cell Physiol Volume: 203 Page(s): 273 - 276
04/01/2005 Authors: Ren Q; Liu R; Dicker A; Wang Y
Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway.
J Cell Physiol Volume: 202 Page(s): 518 - 523
02/01/2005 Authors: Hu B; Han S-Y; Wang X; Ottey M; Potoczek MB; Dicker A; Huebner K; Wang Y
CHK1 affecting cell radiosensitivity is independent of non-homologous end joining.
Cell Cycle Volume: 4 Page(s): 300 - 303
02/01/2005 Authors: Wang H; Hu B; Liu R; Wang Y
Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant.
Br J Cancer Volume: 91 Page(s): 1669 - 1677
11/01/2004 Authors: Ottey M; Han S-Y; Druck T; Barnoski BL; McCorkell KA; Croce CM; Raventos-Suarez C; Fairchild CR; Wang Y; Huebner K
ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining.
Cancer Res Volume: 64 Page(s): 7139 - 7143
10/01/2004 Authors: Wang H; Wang H; Powell SN; Iliakis G; Wang Y
Evidence for an S-phase checkpoint regulating DNA replication after heat shock: a review.
Int J Hyperthermia Volume: 20 Page(s): 240 - 249
03/01/2004 Authors: Iliakis G; Krieg T; Guan J; Wang Y; Leeper D
Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.
Nucleic Acids Res Volume: 32 Page(s): 767 - 775
01/01/2004 Authors: Wang X; Guan J; Hu B; Weiss RS; Iliakis G; Wang Y
DNA damage checkpoint control in cells exposed to ionizing radiation.
Oncogene Volume: 22 Page(s): 5834 - 5847
09/01/2003 Authors: Iliakis G; Wang Y; Guan J; Wang H
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
J Biol Chem Volume: 278 Page(s): 30869 - 30874
08/15/2003 Authors: Wang X; Khadpe J; Hu B; Iliakis G; Wang Y
Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing.
Radiat Res Volume: 159 Page(s): 420 - 425
03/01/2003 Authors: Wang H; Wang X; Iliakis G; Wang Y
Caffeine-induced radiosensitization is independent of nonhomologous end joining of DNA double-strand breaks.
Radiat Res Volume: 159 Page(s): 426 - 432
03/01/2003 Authors: Wang X; Wang H; Iliakis G; Wang Y
Ku affects the CHK1-dependent G(2) checkpoint after ionizing radiation.
Cancer Res Volume: 62 Page(s): 6031 - 6034
11/01/2002 Authors: Wang X; Li GC; Iliakis G; Wang Y
Ku affects the ATM-dependent S phase checkpoint following ionizing radiation.
Oncogene Volume: 21 Page(s): 6377 - 6381
09/12/2002 Authors: Zhou X-Y; Wang X; Wang H; Chen DJ; Li GC; Iliakis G; Wang Y
Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment.
Cancer Res Volume: 62 Page(s): 2483 - 2487
05/01/2002 Authors: Wang H; Wang X; Zhou X-Y; Chen DJ; Li GC; Iliakis G; Wang Y
An ATM-independent S-phase checkpoint response involves CHK1 pathway.
Cancer Res Volume: 62 Page(s): 1598 - 1603
03/15/2002 Authors: Zhou X-Y; Wang X; Hu B; Guan J; Iliakis G; Wang Y
CHK1-regulated S-phase checkpoint response reduces camptothecin cytotoxicity.
Cell Cycle Volume: 1 Page(s): 267 - 272
01/01/2002 Authors: Wang J-L; Wang X; Wang H; Iliakis G; Wang Y
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Cancer Res Volume: 61 Page(s): 8554 - 8563
12/01/2001 Authors: Wang H; Guan J; Wang H; Perrault AR; Wang Y; Iliakis G
Regulation of dna replication after heat shock by replication protein a-nucleolin interactions.
J Biol Chem Volume: 276 Page(s): 20579 - 20588
06/08/2001 Authors: Wang Y; Guan J; Wang H; Wang Y; Leeper D; Iliakis G
The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway.
J Biol Chem Volume: 276 Page(s): 17693 - 17698
05/25/2001 Authors: Hu B; Zhou XY; Wang X; Zeng ZC; Iliakis G; Wang Y
Evidence for factors modulating radiation-induced G2-delay: potential application as radioprotectors.
Volume: 17 Suppl 1 Page(s): 205 - 209
01/01/2001 Authors: Cheong N; Zeng ZC; Wang Y; Iliakis G
Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage.
J Biol Chem Volume: 274 Page(s): 22060 - 22064
07/30/1999 Authors: Wang Y; Zhou XY; Wang H; Huq MS; Iliakis G
A rapid preparation of extracts for DNA replication in vitro.
Radiat Res Volume: 151 Page(s): 59 - 62
01/01/1999 Authors: Wang Y; Wang H
Analysis of inhibition of DNA replication in irradiated cells using the SV40-based in vitro assay of DNA replication.
Methods Mol Biol Volume: 113 Page(s): 543 - 553
01/01/1999 Authors: Iliakis G; Wang Y; Wang HY
Replication protein A as a potential regulator of DNA replication in cells exposed to hyperthermia.
Radiat Res Volume: 149 Page(s): 284 - 293
03/01/1998 Authors: Wang Y; Perrault AR; Iliakis G
Overexpression of insulin-like growth factor (IGF)-I receptor enhances inhibition of DNA replication in mouse cells exposed to x-rays.
Radiat Environ Biophys Volume: 36 Page(s): 117 - 123
06/01/1997 Authors: Wang Y; Cheong N; Miura M; Iliakis G
Down-regulation of DNA replication in extracts of camptothecin-treated cells: activation of an S-phase checkpoint?
Cancer Res Volume: 57 Page(s): 1654 - 1659
05/01/1997 Authors: Wang Y; Perrault AR; Iliakis G
Evidence for activities inhibiting in trans initiation of DNA replication in extract prepared from irradiated cells.
Radiat Res Volume: 145 Page(s): 408 - 418
04/01/1996 Authors: Wang Y; Huq MS; Iliakis G
Ionizing radiation-induced phosphorylation of RPA p34 is deficient in ataxia telangiectasia and reduced in aged normal fibroblasts.
Radiother Oncol Volume: 39 Page(s): 43 - 52
04/01/1996 Authors: Cheng X; Cheong N; Wang Y; Iliakis G
Regulation of DNA replication in irradiated cells by trans-acting factors.
Radiat Res Volume: 142 Page(s): 169 - 175
05/01/1995 Authors: Wang Y; Huq MS; Cheng X; Iliakis G
Mechanism of radiosensitization by halogenated pyrimidines: the contribution of excess DNA and chromosome damage in BrdU radiosensitization may be minimal in plateau-phase cells.
Int J Radiat Biol Volume: 66 Page(s): 133 - 142
08/01/1994 Authors: Wang Y; Pantelias GE; Iliakis G
Loss of S-phase-dependent radioresistance in irs-1 cells exposed to X-rays.
Mutat Res Volume: 314 Page(s): 77 - 85
01/01/1994 Authors: Cheong N; Wang X; Wang Y; Iliakis G
Hypertonic treatment during premature chromosome condensation allows visualization of interphase chromosome breaks repaired with fast kinetics in irradiated CHO cells.
Radiat Res Volume: 135 Page(s): 160 - 170
08/01/1993 Authors: Iliakis G; Okayasu R; Varlotto J; Shernoff C; Wang Y
Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras plus v-myc is cell cycle dependent and maximal during S and G2.
Int J Radiat Biol Volume: 63 Page(s): 623 - 629
05/01/1993 Authors: Cheong N; Wang Y; Iliakis G
Persistent inhibition of DNA synthesis in irradiated rat embryo fibroblasts expressing the oncogenes H-ras plus v-myc derives from inhibition of replicon initiation and is mitigated by staurosporine.
Cancer Res Volume: 53 Page(s): 1213 - 1217
03/15/1993 Authors: Wang Y; Cheong N; Iliakis G
Radiation-sensitive irs mutants rejoin DNA double-strand breaks with efficiency similar to that of parental V79 cells but show altered response to radiation-induced G2 delay.
Mutat Res Volume: 274 Page(s): 111 - 122
08/01/1992 Authors: Cheong N; Wang Y; Jackson M; Iliakis G
Prolonged inhibition by X-rays of DNA synthesis in cells obtained by transformation of primary rat embryo fibroblasts with oncogenes H-ras and v-myc.
Cancer Res Volume: 52 Page(s): 508 - 514
02/01/1992 Authors: Wang Y; Iliakis G
Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on repair of DNA breaks, interphase chromatin breaks, and potentially lethal damage in plateau-phase CHO cells.
Radiat Res Volume: 129 Page(s): 202 - 211
02/01/1992 Authors: Iliakis G; Wang Y; Pantelias GE; Metzger L
Effects of 5'-iododeoxyuridine on the repair of radiation induced potentially lethal damage interphase chromatin breaks and DNA double strand breaks in Chinese hamster ovary cells.
Int J Radiat Oncol Biol Phys Volume: 23 Page(s): 353 - 360
01/01/1992 Authors: Wang Y; Iliakis G

Directory section navigation

Profile

Ya Wang PhD

Academic Appointment

Education

Degrees

Research

Focus

Publications