Publications

• MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer.
  Nat Commun Volume: 16 Page(s): 3552
  04/15/2025 Authors: Chi JJ; Xie P; Cheng MH; Zhu Y; Cui X; Watson J; Zeng L; Uddin A; Nguyen H; Li L
• Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP.
  Adv Sci (Weinh) Volume: 12 Page(s): e2407494
  03/01/2025 Authors: Cui X; Zhu Y; Zeng L; Zhang M; Uddin A; Gillespie TW; McCullough LE; Zhao S; Torres MA; Wan Y
• Ten-Step Total Synthesis of ()-Phaeocaulisin A Enabled by Cyclopropanol Ring-Opening Carbonylation.
  J Am Chem Soc Volume: 146 Page(s): 32276 - 32282
  11/27/2024 Authors: Liu C; Zhang M; Zeng L; Wan Y; Dai M
• Tuning Immune-Cold Tumor by Suppressing USP10/B7-H4 Proteolytic Axis Reinvigorates Therapeutic Efficacy of ADCs.
  Adv Sci (Weinh) Volume: 11 Page(s): e2400757
  10/01/2024 Authors: Zeng L; Zhu Y; Cui X; Chi J; Uddin A; Zhou Z; Song X; Dai M; Cristofanilli M; Kalinsky K
• Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers.
  J Clin Invest Volume: 134
  03/26/2024 Authors: Zhu Y; Banerjee A; Xie P; Ivanov AA; Uddin A; Jiao Q; Chi JJ; Zeng L; Lee JY; Xue Y
• CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4.
  J Clin Invest Volume: 134
  03/05/2024 Authors: Chen S; Fan J; Xie P; Ahn J; Fernandez M; Billingham LK; Miska J; Wu JD; Wainwright DA; Fang D
• New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy.
  Semin Cancer Biol Volume: 90 Page(s): 29 - 44
  05/01/2023 Authors: Zeng L; Zhu Y; Moreno CS; Wan Y
• Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
  Sci Adv Volume: 9 Page(s): eadd6626
  01/06/2023 Authors: Fu Z; Chen S; Zhu Y; Zhang D; Xie P; Jiao Q; Chi J; Xu S; Xue Y; Lu X
• CDC20-Mediated hnRNPU Ubiquitination Regulates Chromatin Condensation and Anti-Cancer Drug Response.
  Cancers (Basel) Volume: 14
  07/31/2022 Authors: Wavelet-Vermuse C; Odnokoz O; Xue Y; Lu X; Cristofanilli M; Wan Y
• Ductal Carcinoma In Situ of Breast: From Molecular Etiology to Therapeutic Management.
  Endocrinology Volume: 163
  04/01/2022 Authors: Hophan SL; Odnokoz O; Liu H; Luo Y; Khan S; Gradishar W; Zhou Z; Badve S; Torres MA; Wan Y
• The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP.
  Signal Transduct Target Ther Volume: 6 Page(s): 264
  07/14/2021 Authors: Zhu X; Zhang Y; Luo Q; Wu X; Huang F; Shu T; Wan Y; Chen H; Liu Z
• ARID1 proteins: from transcriptional and post-translational regulation to carcinogenesis and potential therapeutics.
  Epigenomics Volume: 13 Page(s): 809 - 823
  05/01/2021 Authors: Odnokoz O; Wavelet-Vermuse C; Hophan SL; Bulun S; Wan Y
• Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
  Sci Adv Volume: 7
  04/01/2021 Authors: Park SH; Fong K-W; Kim J; Wang F; Lu X; Lee Y; Brea LT; Wadosky K; Guo C; Abdulkadir SA
• New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy.
  EMBO Mol Med Volume: 12 Page(s): e12391
  12/07/2020 Authors: Zhou Z; Huang F; Shrivastava I; Zhu R; Luo A; Hottiger M; Bahar I; Liu Z; Cristofanilli M; Wan Y
• Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.
  Cancer Discov Volume: 10 Page(s): 1872 - 1893
  12/01/2020 Authors: Song X; Zhou Z; Li H; Xue Y; Lu X; Bahar I; Kepp O; Hung M-C; Kroemer G; Wan Y
• Targeting CD73 to augment cancer immunotherapy.
  Curr Opin Pharmacol Volume: 53 Page(s): 66 - 76
  08/01/2020 Authors: Roh M; Wainwright DA; Wu JD; Wan Y; Zhang B
• EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.
  Cancer Res Volume: 80 Page(s): 2550 - 2563
  06/15/2020 Authors: Zhou Z; Zhou H; Ponzoni L; Luo A; Zhu R; He M; Huang Y; Guan K-L; Bahar I; Liu Z
• Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance.
  Cell Signal Volume: 70 Page(s): 109574
  06/01/2020 Authors: Zhou Z; Song X; Chi JJ; Gius DR; Huang Y; Cristofanilli M; Wan Y
• Finding the Unicorn, a New Mouse Model of Midfacial Clefting.
  Genes (Basel) Volume: 11
  01/11/2020 Authors: Lantz B; White C; Liu X; Wan Y; Gabriel G; Lo CWY; Szabo-Rogers HL
• Cullin 4-DCAF Proteins in Tumorigenesis.
  Adv Exp Med Biol Volume: 1217 Page(s): 241 - 259
  01/01/2020 Authors: Zhou Z; Song X; Wavelet CM; Wan Y
• ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4.
  Cancer Lett Volume: 467 Page(s): 19 - 28
  12/28/2019 Authors: Zou H; Chen H; Zhou Z; Wan Y; Liu Z
• Localization of Tfap2, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye.
  J Histochem Cytochem Volume: 67 Page(s): 863 - 871
  12/01/2019 Authors: Wan Y; White C; Robert N; Rogers MB; Szabo-Rogers HL
• A novel strategy to block mitotic progression for targeted therapy.
  EBioMedicine Volume: 49 Page(s): 40 - 54
  11/01/2019 Authors: Chi JJ; Li H; Zhou Z; Izquierdo-Ferrer J; Xue Y; Wavelet CM; Schiltz GE; Zhang B; Cristofanilli M; Lu X
• CD73: an emerging checkpoint for cancer immunotherapy.
  Immunotherapy Volume: 11 Page(s): 983 - 997
  08/01/2019 Authors: Chen S; Wainwright DA; Wu JD; Wan Y; Matei DE; Zhang Y; Zhang B
• A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy.
  EBioMedicine Volume: 44 Page(s): 98 - 111
  06/01/2019 Authors: Zhou Z; Feng Z; Hu D; Yang P; Gur M; Bahar I; Cristofanilli M; Gradishar WJ; Xie X-Q; Wan Y
• Epithelial Mutations in Endometriosis: Link to Ovarian Cancer.
  Endocrinology Volume: 160 Page(s): 626 - 638
  03/01/2019 Authors: Bulun SE; Wan Y; Matei D
• Prickle1 regulates differentiation of frontal bone osteoblasts.
  Sci Rep Volume: 8 Page(s): 18021
  12/21/2018 Authors: Wan Y; Lantz B; Cusack BJ; Szabo-Rogers HL
• HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.
  Int J Cancer Volume: 143 Page(s): 1388 - 1401
  09/15/2018 Authors: Cao C; Wu H; Vasilatos SN; Chandran U; Qin Y; Wan Y; Oesterreich S; Davidson NE; Huang Y
• Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges.
  Mol Pharm Volume: 15 Page(s): 3625 - 3633
  09/04/2018 Authors: Kibria G; Ramos EK; Wan Y; Gius DR; Liu H
• Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication.
  Pharmacol Ther Volume: 177 Page(s): 96 - 107
  09/01/2017 Authors: He M; Zhou Z; Wu G; Chen Q; Wan Y
• FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation.
  Oncogene Volume: 36 Page(s): 3312 - 3321
  06/08/2017 Authors: Zhou H; Liu Y; Zhu R; Ding F; Wan Y; Li Y; Liu Z
• SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming.
  Cancer Res Volume: 77 Page(s): 2674 - 2685
  05/15/2017 Authors: Gao Y; Li C; Wei L; Teng Y; Nakajima S; Chen X; Xu J; Leger B; Ma H; Spagnol ST
• Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis.
  EBioMedicine Volume: 15 Page(s): 48 - 61
  02/01/2017 Authors: Zhou Z; Luo A; Shrivastava I; He M; Huang Y; Bahar I; Liu Z; Wan Y
• Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations.
  Cancer Res Volume: 76 Page(s): 6785 - 6794
  12/01/2016 Authors: Lu S; Cai C; Yan G; Zhou Z; Wan Y; Chen V; Chen L; Cooper GF; Obeid LM; Hannun YA
• Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.
  Biol Open Volume: 5 Page(s): 323 - 335
  02/16/2016 Authors: Gibbs BC; Damerla RR; Vladar EK; Chatterjee B; Wan Y; Liu X; Cui C; Gabriel GC; Zahid M; Yagi H
• Insights into APC/C: from cellular function to diseases and therapeutics.
  Cell Div Volume: 11 Page(s): 9
  01/01/2016 Authors: Zhou Z; He M; Shah AA; Wan Y
• New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics.
  Cell Div Volume: 11 Page(s): 4
  01/01/2016 Authors: He M; Zhou Z; Shah AA; Hong Y; Chen Q; Wan Y
• The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics.
  Cell Biosci Volume: 6 Page(s): 62
  01/01/2016 Authors: He M; Zhou Z; Shah AA; Zou H; Tao J; Chen Q; Wan Y
• Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
  Nat Commun Volume: 6 Page(s): 8419
  09/30/2015 Authors: Hu D; Gur M; Zhou Z; Gamper A; Hung M-C; Fujita N; Lan L; Bahar I; Wan Y
• Krppel-like Factor 4 Promotes Esophageal Squamous Cell Carcinoma Differentiation by Up-regulating Keratin 13 Expression.
  J Biol Chem Volume: 290 Page(s): 13567 - 13577
  05/22/2015 Authors: He H; Li S; Hong Y; Zou H; Chen H; Ding F; Wan Y; Liu Z
• Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy.
  Cell Mol Life Sci Volume: 71 Page(s): 1549
  04/01/2014 Authors: Zhou Z; Qiao JX; Shetty A; Wu G; Huang Y; Davidson NE; Wan Y
• Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.
  J Biol Chem Volume: 288 Page(s): 18134 - 18145
  06/21/2013 Authors: Zhou Z; Jing C; Zhang L; Takeo F; Kim H; Huang Y; Liu Z; Wan Y
• Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells.
  Carcinogenesis Volume: 34 Page(s): 1196 - 1207
  06/01/2013 Authors: Vasilatos SN; Katz TA; Oesterreich S; Wan Y; Davidson NE; Huang Y
• Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis.
  J Biol Chem Volume: 287 Page(s): 13584 - 13597
  04/20/2012 Authors: Hu D; Zhou Z; Davidson NE; Huang Y; Wan Y
• Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor -initiated prostate cancer epithelial-mesenchymal transition.
  Mol Cell Biol Volume: 32 Page(s): 941 - 953
  03/01/2012 Authors: Liu Y-N; Abou-Kheir W; Yin JJ; Fang L; Hynes P; Casey O; Hu D; Wan Y; Seng V; Sheppard-Tillman H
• Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis.
  Mol Cell Volume: 45 Page(s): 233 - 243
  01/27/2012 Authors: Gamper AM; Qiao X; Kim J; Zhang L; DeSimone MC; Rathmell WK; Wan Y
• The emerging role of APC/CCdh1 in development.
  Semin Cell Dev Biol Volume: 22 Page(s): 579 - 585
  08/01/2011 Authors: Hu D; Qiao X; Wu G; Wan Y
• Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling.
  J Biol Chem Volume: 286 Page(s): 10041 - 10050
  03/25/2011 Authors: Zhang L; Fujita T; Wu G; Xiao X; Wan Y
• Regulation of Krppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling.
  J Biol Chem Volume: 286 Page(s): 6890 - 6901
  03/04/2011 Authors: Hu D; Wan Y
• Nuclear translocation of Skp2 facilitates its destruction in response to TGF signaling.
  Cell Cycle Volume: 10 Page(s): 285 - 292
  01/15/2011 Authors: Hu D; Liu W; Wu G; Wan Y
• Turnover of BRCA1 involves in radiation-induced apoptosis.
  PLoS One Volume: 5 Page(s): e14484
  12/31/2010 Authors: Liu W; Zong W; Wu G; Fujita T; Li W; Wu J; Wan Y
• APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Cell Cycle Volume: 9 Page(s): 3904 - 3912
  10/01/2010 Authors: Qiao X; Zhang L; Gamper AM; Fujita T; Wan Y
• Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.
  EMBO J Volume: 29 Page(s): 1726 - 1737
  05/19/2010 Authors: Zhang L; Park C-H; Wu J; Kim H; Liu W; Fujita T; Balasubramani M; Schreiber EM; Wang X-F; Wan Y
• An in vivo study of Cdh1/APC in breast cancer formation.
  Int J Cancer Volume: 125 Page(s): 826 - 836
  08/15/2009 Authors: Fujita T; Liu W; Doihara H; Wan Y
• Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells.
  Mol Biol Cell Volume: 19 Page(s): 5446 - 5455
  12/01/2008 Authors: Fujita T; Epperly MW; Zou H; Greenberger JS; Wan Y
• Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.
  Am J Pathol Volume: 173 Page(s): 217 - 228
  07/01/2008 Authors: Fujita T; Liu W; Doihara H; Wan Y
• Dissection of the APCCdh1-Skp2 cascade in breast cancer.
  Clin Cancer Res Volume: 14 Page(s): 1966 - 1975
  04/01/2008 Authors: Fujita T; Liu W; Doihara H; Date H; Wan Y
• Proteolysis of CDH1 enhances susceptibility to UV radiation-induced apoptosis.
  Carcinogenesis Volume: 29 Page(s): 263 - 272
  02/01/2008 Authors: Liu W; Li W; Fujita T; Yang Q; Wan Y
• The dual effects of Cdh1/APC in myogenesis.
  FASEB J Volume: 21 Page(s): 3606 - 3617
  11/01/2007 Authors: Li W; Wu G; Wan Y
• Clinical significance of Cdh1-Skp2 cascade in breast cancer
  Volume: 25
  06/20/2007 Authors: Fujita T; Wu G; Wood RD; Wan Y
• Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition.
  Mol Cell Biol Volume: 27 Page(s): 2967 - 2979
  04/01/2007 Authors: Liu W; Wu G; Li W; Lobur D; Wan Y
• The anaphase-promoting complex coordinates initiation of lens differentiation.
  Mol Biol Cell Volume: 18 Page(s): 1018 - 1029
  03/01/2007 Authors: Wu G; Glickstein S; Liu W; Fujita T; Li W; Yang Q; Duvoisin R; Wan Y
• Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34.
  Oncogene Volume: 23 Page(s): 5643 - 5653
  07/22/2004 Authors: Macdonald M; Wan Y; Wang W; Roberts E; Cheung TH; Erickson R; Knuesel MT; Liu X
• Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.
  Nature Volume: 428 Page(s): 194 - 198
  03/11/2004 Authors: Wei W; Ayad NG; Wan Y; Zhang G-J; Kirschner MW; Kaelin WG
• Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system.
  Mol Cell Proteomics Volume: 2 Page(s): 1225 - 1233
  11/01/2003 Authors: Knuesel M; Wan Y; Xiao Z; Holinger E; Lowe N; Wang W; Liu X
• Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities.
  Proc Natl Acad Sci U S A Volume: 98 Page(s): 13066 - 13071
  11/06/2001 Authors: Wan Y; Kirschner MW
• The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction.
  Mol Cell Volume: 8 Page(s): 1027 - 1039
  11/01/2001 Authors: Wan Y; Liu X; Kirschner MW
• The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.
  Nature Volume: 395 Page(s): 808 - 813
  10/22/1998 Authors: Jiang Y; Ma W; Wan Y; Kozasa T; Hattori S; Huang XY
• Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells.
  J Biol Chem Volume: 273 Page(s): 14533 - 14537
  06/05/1998 Authors: Wan Y; Huang XY
• Genetic evidence for a tyrosine kinase cascade preceding the mitogen-activated protein kinase cascade in vertebrate G protein signaling.
  J Biol Chem Volume: 272 Page(s): 17209 - 17215
  07/04/1997 Authors: Wan Y; Bence K; Hata A; Kurosaki T; Veillette A; Huang XY
• Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors.
  Nature Volume: 380 Page(s): 541 - 544
  04/11/1996 Authors: Wan Y; Kurosaki T; Huang XY
• Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.
  Proc Natl Acad Sci U S A Volume: 92 Page(s): 8601 - 8605
  09/12/1995 Authors: Langhans-Rajasekaran SA; Wan Y; Huang XY