Publications

• Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target.
  Sci Transl Med Volume: 17 Page(s): eadl4922
  07/16/2025 Authors: Chonat S; Jones JA; Patel SR; Briones WM; Schoettler ML; Maarouf M; Jeffers LA; Adisa O; Tan F; Fields E
• Clinically relevant clot resolution via a thromboinflammation-on-a-chip.
  Nature Volume: 641 Page(s): 1298 - 1308
  05/01/2025 Authors: Qiu Y; Lin J; Wang A; Fang Z; Sakurai Y; Choi H; Williams EK; Hardy ET; Maher K; Coskun AF
• INTRODUCING A BIOPHYSICAL PLATELET FUNCTION PANEL TO INVESTIGATE BLEEDING OF UNKNOWN CAUSE
  Volume: 69
  06/01/2022 Authors: Azer S; Oshinowo O; Fay M; Sakurai Y; Qiu Y; Bennett C; Meeks S; Brown M; Myers D; Lam W
• Platelet-rich plasma as endothelial rocket fuel for engineered in vitro microvasculature.
  J Thromb Haemost Volume: 18 Page(s): 1239 - 1241
  06/01/2020 Authors: Qiu Y; Lam WA
• Vascularized Microfluidics and the Blood-Endothelium Interface.
  Micromachines (Basel) Volume: 11
  12/23/2019 Authors: Hesh CA; Qiu Y; Lam WA
• The biophysics and mechanics of blood from a materials perspective.
  Nat Rev Mater Volume: 4 Page(s): 294 - 311
  05/01/2019 Authors: Qiu Y; Myers DR; Lam WA
• Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
  Cell Stem Cell Volume: 24 Page(s): 608 - 620.e6
  04/04/2019 Authors: Ni F; Yu W-M; Wang X; Fay ME; Young KM; Qiu Y; Lam WA; Sulchek TA; Cheng T; Scadden DT
• Endothelial cell culture in microfluidic devices for investigating microvascular processes.
  Biomicrofluidics Volume: 12 Page(s): 042203
  07/01/2018 Authors: Mannino RG; Qiu Y; Lam WA
• Platelet Mechanotransduction.
  Annu Rev Biomed Eng Volume: 20 Page(s): 253 - 275
  06/04/2018 Authors: Hansen CE; Qiu Y; McCarty OJT; Lam WA
• A microengineered vascularized bleeding model that integrates the principal components of hemostasis.
  Nat Commun Volume: 9 Page(s): 509
  02/06/2018 Authors: Sakurai Y; Hardy ET; Ahn B; Tran R; Fay ME; Ciciliano JC; Mannino RG; Myers DR; Qiu Y; Carden MA
• Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation.
  Proc Natl Acad Sci U S A Volume: 115 Page(s): 325 - 330
  01/09/2018 Authors: Zhang Y; Qiu Y; Blanchard AT; Chang Y; Brockman JM; Ma VP-Y; Lam WA; Salaita K
• Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease.
  Nat Biomed Eng Volume: 2 Page(s): 453 - 463
  01/01/2018 Authors: Qiu Y; Ahn B; Sakurai Y; Hansen CE; Tran R; Mimche PN; Mannino RG; Ciciliano JC; Lamb TJ; Joiner CH
• Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency.
  Mol Ther Volume: 25 Page(s): 2372 - 2382
  10/04/2017 Authors: Tran R; Myers DR; Denning G; Shields JE; Lytle AM; Alrowais H; Qiu Y; Sakurai Y; Li WC; Brand O
• Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions.
  Nat Commun Volume: 8 Page(s): 15594
  06/08/2017 Authors: Qiu Y; Tong S; Zhang L; Sakurai Y; Myers DR; Hong L; Lam WA; Bao G
• Single-platelet nanomechanics measured by high-throughput cytometry.
  Nat Mater Volume: 16 Page(s): 230 - 235
  02/01/2017 Authors: Myers DR; Qiu Y; Fay ME; Tennenbaum M; Chester D; Cuadrado J; Sakurai Y; Baek J; Tran R; Ciciliano JC
• 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro.
  Lab Chip Volume: 17 Page(s): 407 - 414
  01/31/2017 Authors: Mannino RG; Santiago-Miranda AN; Pradhan P; Qiu Y; Mejias JC; Neelapu SS; Roy K; Lam WA
• Cyclic tension promotes fibroblastic differentiation of human MSCs cultured on collagen-fibre scaffolds.
  J Tissue Eng Regen Med Volume: 10 Page(s): 989 - 999
  12/01/2016 Authors: Qiu Y; Lei J; Koob TJ; Temenoff JS
• Improving Lentiviral Transduction Efficiency with Microfluidic Systems
  Volume: 126
  12/03/2015 Authors: Tran R; Myers DR; Shields JE; Ahn B; Qiu Y; Hansen C; Sakurai Y; Moot R; Spencer HT; Doering CB
• Engineering a "Self -Healing" Hydrogel-Based Microvasculature-on-a-Chip for Investigating the Effects of Cellular and Biomolecular Interactions on Endothelial Permeability in Sickle Cell Disease
  Volume: 126
  12/03/2015 Authors: Qiu Y; Ahn B; Sakurai Y; Hansen C; Joiner CH; Ofori-Acquah SF; Lam WA
• Platelets and physics: How platelets "feel" and respond to their mechanical microenvironment.
  Blood Rev Volume: 29 Page(s): 377 - 386
  11/01/2015 Authors: Qiu Y; Ciciliano J; Myers DR; Tran R; Lam WA
• Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.
  Ann Biomed Eng Volume: 43 Page(s): 2036 - 2046
  09/01/2015 Authors: Seto SP; Parks AN; Qiu Y; Soslowsky LJ; Karas S; Platt MO; Temenoff JS
• Platelet geometry sensing spatially regulates -granule secretion to enable matrix self-deposition.
  Blood Volume: 126 Page(s): 531 - 538
  07/23/2015 Authors: Sakurai Y; Fitch-Tewfik JL; Qiu Y; Ahn B; Myers DR; Tran R; Fay ME; Ding L; Spearman PW; Michelson AD
• Platelet mechanosensing of collagen matrices.
  PLoS One Volume: 10 Page(s): e0126624
  01/01/2015 Authors: Kee MF; Myers DR; Sakurai Y; Lam WA; Qiu Y
• "Self-Deposition" of Matrix Proteins from Platelet alpha-Granules Enable Extended Adhesion and Spreading on Micron/Submicron-Scale Fibrinogen and Collagen Substrates.
  Volume: 124
  12/06/2014 Authors: Sakurai Y; Fitch-Tewfik JL; Qiu Y; Myers DR; Ahn B; Flaumenhaft R; Lam WA
• Platelet Mechanosensing of Collagen Matrices
  Volume: 124
  12/06/2014 Authors: Kee MF; Qiu Y; Myers DR; Sakurai Y; Lam WA
• Platelet Adhesion, Spreading and Activation Are Mediated By Mechanosensing of Matrix Stiffness
  Volume: 124
  12/06/2014 Authors: Qiu Y; Brown AC; Myers DR; Sakurai Y; Mannino R; Tran R; Ahn B; Hardy E; Kee MF; Kumar S
• Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): 14430 - 14435
  10/07/2014 Authors: Qiu Y; Brown AC; Myers DR; Sakurai Y; Mannino RG; Tran R; Ahn B; Hardy ET; Kee MF; Kumar S
• Simplified prototyping of perfusable polystyrene microfluidics.
  Biomicrofluidics Volume: 8 Page(s): 046501
  07/01/2014 Authors: Tran R; Ahn B; Myers DR; Qiu Y; Sakurai Y; Moot R; Mihevc E; Trent Spencer H; Doering C; A Lam W
• Biomechanics of haemostasis and thrombosis in health and disease: from the macro- to molecular scale.
  J Cell Mol Med Volume: 17 Page(s): 579 - 596
  05/01/2013 Authors: Tran R; Myers DR; Ciciliano J; Trybus Hardy EL; Sakurai Y; Ahn B; Qiu Y; Mannino RG; Fay ME; Lam WA
• An "Endothelialized" Microfluidic System That Distinguishes Procoagulant Mechanisms in Arterial and Venous Thrombosis
  Volume: 120
  11/16/2012 Authors: Ahn B; Sakurai Y; Myers DR; Qiu Y; Hardy E; Tran R; Mannino R; Wolberg AS; Lam W
• PEG-based hydrogels with tunable degradation characteristics to control delivery of marrow stromal cells for tendon overuse injuries.
  Acta Biomater Volume: 7 Page(s): 959 - 966
  03/01/2011 Authors: Qiu Y; Lim JJ; Scott L; Adams RC; Bui HT; Temenoff JS
• ENDOTHELIALIZED MICROSCALE CULTURE SYSTEMS: A NOVEL PLATFORM FOR TUMOR MICROENVIRONMENT STUDIES
  
  Authors: Mitchell S; Qiu Y; Sakurai Y; Lam W