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Profile

Yesim Polar

  • Department of Pathology and Laboratory Medicine
    Associate Professor
  • (404) 727-8998
  • ypolar@emory.edu
  • My Porfolio
  • Emory University School of Medicine
    Pathology and Laboratory Medicine
    Emory Winship Cancer Institute, 1365 E Clifton RD NE, C3080
Head shot of Yesim Polar

Overview

Dr. Polar (Gkmen-Polar) 's research focuses on the identification of novel targets for therapy- resistant breast cancer leading to the development of targeted therapies. She has established laboratory models for acquired resistance in breast cancer and thymic malignancies, which has allowed for both identification of novel targets and validation of novel targeted therapies and provided the basis for clinical trials of novel therapeutics.
She has developed, validated, and patented gene signatures for Thymoma and Breast cancer.

Academic Appointment

  • Associate Professor, Emory Laney Graduate School, Cancer Biology Graduate Program (CB), Graduate Division of Biological , Emory University
  • Associate Professor, Pathology and Laboratory Medicine, Emory University School of Medicine
  • Associate Director, Pathology Cancer Program, Pathology and Laboratory Medicine, Emory University School of Medicine

Education

Degrees

  • PhD from Bogazici University, Molecular Biology and Genetics
  • MS from Bogazici University

Research

Publications

  • MorphLink: Bridging Cell Morphological Behaviors and Molecular Dynamics in Multi-modal Spatial Omics.
    bioRxiv
    08/26/2024 Authors: Huang J; Yuan C; Jiang J; Chen J; Badve SS; Gokmen-Polar Y; Segura RL; Yan X; Lazar A; Gao J
  • Triple Negative Breast Cancers: An Obsolete Entity?
    Clin Breast Cancer Volume: 24 Page(s): 1 - 6
    01/01/2024 Authors: Keskinklc M; Gkmen-Polar Y; Badve SS
  • Dual Prognostic Classification of Triple-Negative Breast Cancer by DNA Damage Immune Response and Homologous Recombination Deficiency.
    JCO Precis Oncol Volume: 7 Page(s): e2300197
    09/01/2023 Authors: Stecklein SR; Barlow W; Pusztai L; Timms K; Kennedy R; Logan GE; Seitz R; Badve S; Gkmen-Polar Y; Porter P
  • Genome-scale metabolic modeling suggests novel molecular targets in ER-positive breast cancer
    Volume: 83
    04/01/2023 Authors: Mudge ZB; Kovacs K; Kemp ML; Badve SS; Gokmen-Polar Y
  • Predicting Breast Cancer Events in Ductal Carcinoma In Situ (DCIS) Using Generative Adversarial Network Augmented Deep Learning Model.
    Cancers (Basel) Volume: 15
    03/23/2023 Authors: Ghose S; Cho S; Ginty F; McDonough E; Davis C; Zhang Z; Mitra J; Harris AL; Thike AA; Tan PH
  • A predictor of response in HER2+ breast cancer-at last!
    J Natl Cancer Inst Volume: 115 Page(s): 242 - 245
    03/09/2023 Authors: Badve SS; Gkmen-Polar Y
  • The Role of ESRP1 in the Regulation of PHGDH in Estrogen Receptor-Positive Breast Cancer.
    Lab Invest Volume: 103 Page(s): 100002
    03/01/2023 Authors: Gkmen-Polar Y; Gu Y; Polar A; Gu X; Badve SS
  • Targeting the Tumor-Tumor Microenvironment Crosstalk.
    Expert Opin Ther Targets Volume: 27 Page(s): 447 - 457
    01/01/2023 Authors: Badve SS; Gkmen-Polar Y
  • Spatially variant immune infiltration scoring in human cancer tissues.
    NPJ Precis Oncol Volume: 6 Page(s): 60
    09/01/2022 Authors: Allam M; Hu T; Lee J; Aldrich J; Badve SS; Gkmen-Polar Y; Bhave M; Ramalingam SS; Schneider F; Coskun AF
  • Tumor Infiltrating Lymphocytes in Multi-National Cohorts of Ductal Carcinoma In Situ (DCIS) of Breast.
    Cancers (Basel) Volume: 14
    08/13/2022 Authors: Badve SS; Cho S; Lu X; Cao S; Ghose S; Thike AA; Tan PH; Ocal IT; Generali D; Zanconati F
  • Is conservative management of ductal carcinoma in situ risky?
    NPJ Breast Cancer Volume: 8 Page(s): 55
    04/28/2022 Authors: Zheng L; Gkmen-Polar Y; Badve SS
  • Protein Profiling of Breast Cancer for Treatment Decision-Making.
    Am Soc Clin Oncol Educ Book Volume: 42 Page(s): 1 - 9
    04/01/2022 Authors: Badve SS; Gkmen-Polar Y
  • Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type.
    Oncotarget Volume: 12 Page(s): 1178 - 1186
    06/08/2021 Authors: Padda SK; Gkmen-Polar Y; Hellyer JA; Badve SS; Singh NK; Vasista SM; Basu K; Kumar A; Wakelee HA
  • Thymic Carcinomas and Second Malignancies: A Single-Center Review.
    Cancers (Basel) Volume: 13
    05/19/2021 Authors: Badve SS; Dougherty R; Balatico M; Kesler KA; Loehrer P; Gkmen-Polar Y
  • Multi-protein spatial signatures in ductal carcinoma in situ (DCIS) of breast.
    Br J Cancer Volume: 124 Page(s): 1150 - 1159
    03/01/2021 Authors: Badve SS; Cho S; Gkmen-Polar Y; Sui Y; Chadwick C; McDonough E; Sood A; Taylor M; Zavodszky M; Tan PH
  • CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer.
    Sci Rep Volume: 11 Page(s): 4691
    02/25/2021 Authors: Craven KE; Gkmen-Polar Y; Badve SS
  • ColoType: a forty gene signature for consensus molecular subtyping of colorectal cancer tumors using whole-genome assay or targeted RNA-sequencing.
    Sci Rep Volume: 10 Page(s): 12123
    07/21/2020 Authors: Buechler SA; Stephens MT; Hummon AB; Ludwig K; Cannon E; Carter TC; Resnick J; Gkmen-Polar Y; Badve SS
  • Is Conservative Management of Ductal Carcinoma-In-Situ Risky?
    Volume: 100 Page(s): 292 - 293
    03/01/2020 Authors: Zheng L; Gokmen-Polar Y; Badve S
  • Expression of PD-L1 Family Members in Breast Cancer
    Volume: 33 Page(s): 106 - 106
    03/01/2020 Authors: Badve S; Saxena R; Gokmen-Polar Y; Yu J
  • Is Conservative Management of Ductal Carcinoma-In-Situ Risky?
    Volume: 33 Page(s): 292 - 293
    03/01/2020 Authors: Zheng L; Gokmen-Polar Y; Badve S
  • Expression of PD-L1 Family Members in Breast Cancer
    Volume: 100 Page(s): 106 - 106
    03/01/2020 Authors: Badve S; Saxena R; Gokmen-Polar Y; Yu J
  • Molecular Pathways Associated with Recurrence of Ductal Carcinoma In Situ in Singaporeans
    Volume: 100 Page(s): 154 - 155
    03/01/2020 Authors: Gokmen-Polar Y; Thike AA; Tan PH; Gu X; Cho S; Harris A; Ginty F; Badve S
  • Molecular Pathways Associated with Recurrence of Ductal Carcinoma In Situ in Singaporeans
    Volume: 33 Page(s): 154 - 155
    03/01/2020 Authors: Gokmen-Polar Y; Thike AA; Tan PH; Gu X; Cho S; Harris A; Ginty F; Badve S
  • Ethnicity-dependent alternative RNA splicing variations of estrogen receptor in breast cancer
    Volume: 80
    02/01/2020 Authors: Gokmen-Polar Y; Badve SS
  • Validation of the DNA Damage Immune Response Signature in Patients With Triple-Negative Breast Cancer From the SWOG 9313c Trial.
    J Clin Oncol Volume: 37 Page(s): 3484 - 3492
    12/20/2019 Authors: Sharma P; Barlow WE; Godwin AK; Parkes EE; Knight LA; Walker SM; Kennedy RD; Harkin DP; Logan GE; Steele CJ
  • Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive, Early Breast Cancer.
    JNCI Cancer Spectr Volume: 3 Page(s): pkz051
    12/01/2019 Authors: Buechler SA; Gray KP; Gkmen-Polar Y; Willis S; Thrlimann B; Kammler R; Viale G; Leyland-Jones B; Badve SS; Regan MM
  • TP53 Status and Estrogen Receptor-Beta in Triple-Negative Breast Cancer: Company Matters.
    J Natl Cancer Inst Volume: 111 Page(s): 1118 - 1119
    11/01/2019 Authors: Badve SS; Gkmen-Polar Y
  • Ductal carcinoma in situ of breast: update 2019.
    Pathology Volume: 51 Page(s): 563 - 569
    10/01/2019 Authors: Badve SS; Gkmen-Polar Y
  • A novel role for ESRP1 in regulating proliferation in therapy-resistant ER-positive breast cancer
    Volume: 79
    07/01/2019 Authors: Gokmen-Polar Y; Gu Y; Gu X; Badve SS
  • Three-dimensional imaging and quantitative analysis in CLARITY processed breast cancer tissues.
    Sci Rep Volume: 9 Page(s): 5624
    04/04/2019 Authors: Chen Y; Shen Q; White SL; Gokmen-Polar Y; Badve S; Goodman LJ
  • ColotypeR gene signature predicts response to cetuximab in colorectal cancer metastases.
    Volume: 37
    02/01/2019 Authors: Buechler SA; Gokmen-Polar Y; Badve SS
  • CMS-PDX: A 20-gene genomic panel to predict consensus molecular subtypes in patient-derived xenografts (PDX) of colorectal cancer.
    Volume: 37
    02/01/2019 Authors: Buechler SA; Gokmen-Polar Y; Badve SS
  • Expression score (Escore) for the prediction of likelihood of recurrence of DCIS
    Volume: 79
    02/01/2019 Authors: Badve SS; Cho S; Gokmen-Polar Y; Zavodszky M; Sui Y; Chadwick C; Tan PH; Gerdes M; Harris AL; Ginty F
  • Splicing factor ESRP1 controls ER-positive breast cancer progression by altering metabolic pathway genes
    Volume: 79
    02/01/2019 Authors: Gokmen-Polar Y; Gu Y; Gu X; Badve SS
  • Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways.
    EMBO Rep Volume: 20
    02/01/2019 Authors: Gkmen-Polar Y; Neelamraju Y; Goswami CP; Gu Y; Gu X; Nallamothu G; Vieth E; Janga SC; Ryan M; Badve SS
  • EarlyR signature predicts response to neoadjuvant chemotherapy in breast cancer.
    Breast Volume: 43 Page(s): 74 - 80
    02/01/2019 Authors: Buechler SA; Gkmen-Polar Y; Badve SS
  • EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor-Positive Breast Cancer.
    Clin Breast Cancer Volume: 19 Page(s): 17 - 26.e8
    02/01/2019 Authors: Buechler SA; Gkmen-Polar Y; Badve SS
  • HSF1 as a Cancer Biomarker and Therapeutic Target.
    Curr Cancer Drug Targets Volume: 19 Page(s): 515 - 524
    01/01/2019 Authors: Carpenter RL; Gkmen-Polar Y
  • Identification of Molecular Subtypes of Thymic Epithelial Tumors and Novel Treatments Using a Computational Biological Model
    Volume: 13 Page(s): S606 - S606
    10/01/2018 Authors: Padda S; Gokmen-Polar Y; Badve S; Vasista S; Basu K; Kumar A; Vali S; Abbasi T; Wakelee H
  • Quantitative phosphoproteome analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor-positive breast cancer
    Volume: 78
    07/01/2018 Authors: Gokmen-Polar Y; True JD; Vieth E; Gu Y; Gu X; Qi GD; Mosley AL; Badve S
  • Single-cell heterogeneity in ductal carcinoma in situ of breast.
    Mod Pathol Volume: 31 Page(s): 406 - 417
    03/01/2018 Authors: Gerdes MJ; Gkmen-Polar Y; Sui Y; Pang AS; LaPlante N; Harris AL; Tan P-H; Ginty F; Badve SS
  • CIBERSORT Analysis of TCGA Identifies Subgroups with Better Outcomes in Triple Negative Breast Cancer
    Volume: 98 Page(s): 56 - 56
    03/01/2018 Authors: Craven K; Gokmen-Polar Y; Badve S
  • Thymic Carcinoma-Associated Second Malignancies: A Single-Center Review
    Volume: 98 Page(s): 748 - 748
    03/01/2018 Authors: Rominger RE; Badve S; Gokmen-Polar Y
  • Impact of Estrogen Receptor Variants on Allred Score and Breast Cancer Outcomes
    Volume: 98 Page(s): 63 - 64
    03/01/2018 Authors: Gokmen-Polar Y; Neelamraju Y; Buechler SA; Badve S
  • Thymic Carcinoma-Associated Second Malignancies: A Single-Center Review
    Volume: 31 Page(s): 748 - 748
    03/01/2018 Authors: Rominger RE; Badve S; Gokmen-Polar Y
  • CIBERSORT Analysis of TCGA Identifies Subgroups with Better Outcomes in Triple Negative Breast Cancer
    Volume: 31 Page(s): 56 - 56
    03/01/2018 Authors: Craven K; Gokmen-Polar Y; Badve S
  • Impact of Estrogen Receptor Variants on Allred Score and Breast Cancer Outcomes
    Volume: 31 Page(s): 63 - 64
    03/01/2018 Authors: Gokmen-Polar Y; Neelamraju Y; Buechler SA; Badve S
  • The Integrated Genomic Landscape of Thymic Epithelial Tumors.
    Cancer Cell Volume: 33 Page(s): 244 - 258.e10
    02/12/2018 Authors: Radovich M; Pickering CR; Felau I; Ha G; Zhang H; Jo H; Hoadley KA; Anur P; Zhang J; McLellan M
  • ColotypeR: A tool to classify colon cancers by consensus molecular subtype and subtype-specific risk of recurrence.
    Volume: 36
    02/01/2018 Authors: Buechler SA; Badve SS; Gokmen-Polar Y; Herring E; Ludwig K; Hummon A
  • Three-dimensional (3D) imaging of biomarkers in human core needle biopsies of normal and cancerous breast tissue
    Volume: 78
    02/01/2018 Authors: Chen Y; Shen Q; Goodman LJ; Gokmen-Polar Y; Badve SS
  • Aggressiveness of epithelial cancers is independent of epithelial-to-mesenchymal transition
    Volume: 78
    02/01/2018 Authors: Badve SS; Neelamraju Y; Goswami CP; Gu X; Nallamothu G; Gu Y; Vieth E; Janga SC; Ryan M; Gokmen-Polar Y
  • Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer.
    PLoS One Volume: 13 Page(s): e0204658
    01/01/2018 Authors: Gkmen-Polar Y; True JD; Vieth E; Gu Y; Gu X; Qi GD; Mosley AL; Badve SS
  • Targeting BTK family in ER plus breast cancer with Ibrutinib for personalized precision medicine: a double-edged sword
    Volume: 77
    07/01/2017 Authors: Gokmen-Polar Y; Gu X; Vieth E; Badve S
  • Phosphopeptide mapping of DLC1 in ER+ breast cancer reveals AMOTL2, a key hippo pathway component, as an important target.
    Volume: 35
    05/20/2017 Authors: Gokmen-Polar Y; True JD; Vieth E; Qi GD; Mosley AL; Badve SS
  • EarlyR genomic signature to predict pathological complete response following neoadjuvant anthracycline-taxane chemotherapy in estrogen-receptor positive (ER plus ) breast cancer.
    Volume: 35
    05/20/2017 Authors: Buechler SA; Badve SS; Gokmen-Polar Y
  • Impact of DNA repair deficiency signature on outcomes in triple negative breast cancer (TNBC) patients treated with AC chemotherapy (SWOG 59313).
    Volume: 35
    05/20/2017 Authors: Sharma P; Barlow WE; Godwin AK; Knight LA; Walker SM; Kennedy RD; Badve SS; Gokmen-Polar Y; Pathak HB; Isakova K
  • Loss of DEEBC Expression Is Lost Early in Breast Cancer Development
    Volume: 30 Page(s): 43A - 43A
    02/01/2017 Authors: Gokmen-Polar Y; Zavodszky M; Chen X; Gu X; Kodira C; Badve S
  • RespondR Signature Identifies Triple-Negative Breast Cancer Patients Who Are Likely to Be Insensitive to Taxane Treatment
    Volume: 30 Page(s): 30A - 30A
    02/01/2017 Authors: Badve S; Gokmen-Polar Y; Buechler SA
  • Loss of DEEBC Expression Is Lost Early in Breast Cancer Development
    Volume: 97 Page(s): 43A - 43A
    02/01/2017 Authors: Gokmen-Polar Y; Zavodszky M; Chen X; Gu X; Kodira C; Badve S
  • Impact of heterogeneity of DCIS on immune cell infiltrations
    Volume: 77
    02/01/2017 Authors: Badve S; Gokmen-Polar Y; Harris AL; Sui Y; Sevinsky C; Santamaria-Pang A; Ginty F; Tan PH; Gerdes MJ
  • Thymic Carcinoma Histology and Prognosis- A Single-Center Review
    Volume: 30 Page(s): 492A - 492A
    02/01/2017 Authors: Rominger RE; Balatico MA; Gokmen-Polar Y; Badve S
  • Thymic Carcinoma Histology and Prognosis- A Single-Center Review
    Volume: 97 Page(s): 492A - 492A
    02/01/2017 Authors: Rominger RE; Balatico MA; Gokmen-Polar Y; Badve S
  • RespondR Signature Identifies Triple-Negative Breast Cancer Patients Who Are Likely to Be Insensitive to Taxane Treatment
    Volume: 97 Page(s): 30A - 30A
    02/01/2017 Authors: Badve S; Gokmen-Polar Y; Buechler SA
  • Upregulation of HSF1 in estrogen receptor positive breast cancer.
    Oncotarget Volume: 7 Page(s): 84239 - 84245
    12/20/2016 Authors: Gkmen-Polar Y; Badve S
  • RespondR signature to predict response in TNBC patients treated with adjuvant taxane based chemotherapy in TCGA dataset.
    Volume: 34
    05/20/2016 Authors: Buechler SA; Gokmen-Polar Y; Badve SS
  • RespondR signature to predict potential alternative therapies for taxane resistant triple-negative breast cancer patients.
    Volume: 34
    05/20/2016 Authors: Buechler SA; Gokmen-Polar Y; Badve SS
  • NUT Midline Carcinoma Masquerading As a Thymic Carcinoma.
    J Clin Oncol Volume: 34 Page(s): e126 - e129
    05/10/2016 Authors: Gkmen-Polar Y; Kesler K; Loehrer PJ; Badve S
  • LINC00478: A novel tumor suppressor in breast cancer
    Volume: 76
    02/15/2016 Authors: Gokmen-Polar Y; Zavodszky M; Chen X; Gu X; Kodira C; Badve S
  • Co-Amplification of Chromosome 17 Genes Impacts HER2 Scoring
    Volume: 29 Page(s): 31A - 31A
    02/01/2016 Authors: Badve S; Gokmen-Polar Y
  • Loss of LINC00478 Expression Is Associated with Development of Nodal Metastasis in ER plus Breast Cancer
    Volume: 96 Page(s): 43A - 43A
    02/01/2016 Authors: Gokmen-Polar Y; Zavodszky M; Chen X; Gu X; Kodira C; Badve S
  • Loss of LINC00478 Expression Is Associated with Development of Nodal Metastasis in ER plus Breast Cancer
    Volume: 29 Page(s): 43A - 43A
    02/01/2016 Authors: Gokmen-Polar Y; Zavodszky M; Chen X; Gu X; Kodira C; Badve S
  • Co-Amplification of Chromosome 17 Genes Impacts HER2 Scoring
    Volume: 96 Page(s): 31A - 31A
    02/01/2016 Authors: Badve S; Gokmen-Polar Y
  • Identification of novel immunomodulatory tumor biology through comprehensive characterization of a metastases-specific epigenome in patients with metachronous primary and metastatic urothelial carcinoma (UC) tumor pairs.
    Volume: 34
    01/10/2016 Authors: Hahn NM; Cramer HM; Badve SS; Cheng L; Gokmen-Polar Y; Miller DF; Buechlein A; Rusch DB; Fang F; Frankhouser D
  • Micronodular thymic neoplasms: case series and literature review with emphasis on the spectrum of differentiation.
    Mod Pathol Volume: 28 Page(s): 1415 - 1427
    11/01/2015 Authors: Mneimneh WS; Gkmen-Polar Y; Kesler KA; Loehrer PJ; Badve S
  • Breast cancer prognostic markers: an overview of a changing menu.
    MLO Med Lab Obs Volume: 47 Page(s): 8 - 13
    10/01/2015 Authors: Gkmen-Polar Y; Badve S
  • Tumor Heterogeneity in Breast Cancer.
    Adv Anat Pathol Volume: 22 Page(s): 294 - 302
    09/01/2015 Authors: Badve S; Gkmen-Polar Y
  • Single-cell screening and quantification of transcripts in cancer tissues by second-harmonic generation microscopy.
    J Biomed Opt Volume: 20 Page(s): 096016
    09/01/2015 Authors: Liu J; Damayanti NP; Cho I-H; Polar Y; Badve S; Irudayaraj JMK
  • Novel DNA methylation therapeutic targets in urothelial carcinoma (UC) from patients with paired metachronous primary and metastatic tumors
    Volume: 51 Page(s): S529 - S529
    09/01/2015 Authors: Hahn N; Cramer H; Badve S; Cheng L; Gokmen-Polar Y; Miller D; Buechlein A; Rusch D; Fang F; Frankhouser D
  • RespondR: A genomic score to predict the responsiveness of triple-negative breast cancer patients to chemotherapy
    Volume: 33
    05/20/2015 Authors: Buechler S; Gokmen-Polar Y; Badve SS
  • Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer.
    Mod Pathol Volume: 28 Page(s): 677 - 685
    05/01/2015 Authors: Gkmen-Polar Y; Neelamraju Y; Goswami CP; Gu X; Nallamothu G; Janga SC; Badve S
  • Differential expression of innate and adaptive immune responses in TNBC outcome
    Volume: 75
    05/01/2015 Authors: Gokmen-Polar Y; Lai X; Badve S
  • ESRP1 adds sp(l)ice to endocrine resistance
    Volume: 75
    05/01/2015 Authors: Gokmen-Polar Y; Neelamraju Y; Goswami CP; Nakshatri H; Janga SC; Badve S
  • Prognostic impact of HOTAIR expression is restricted to ER-negative breast cancers.
    Sci Rep Volume: 5 Page(s): 8765
    03/05/2015 Authors: Gkmen-Polar Y; Vladislav IT; Neelamraju Y; Janga SC; Badve S
  • Role of lncRNAs in health and disease-size and shape matter.
    Brief Funct Genomics Volume: 14 Page(s): 115 - 129
    03/01/2015 Authors: Mohanty V; Gkmen-Polar Y; Badve S; Janga SC
  • Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients.
    J Neurooncol Volume: 122 Page(s): 205 - 216
    03/01/2015 Authors: Duchnowska R; Jassem J; Goswami CP; Dundar M; Gkmen-Polar Y; Li L; Woditschka S; Biernat W; Sosiska-Mielcarek K; Czartoryska-Arukowicz B
  • NUT midline carcinomas in the thymic region.
    Mod Pathol Volume: 27 Page(s): 1649 - 1656
    12/01/2014 Authors: Gkmen-Polar Y; Cano OD; Kesler KA; Loehrer PJ; Badve S
  • Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.
    Clin Exp Metastasis Volume: 31 Page(s): 771 - 786
    10/01/2014 Authors: Marino N; Collins JW; Shen C; Caplen NJ; Merchant AS; Gkmen-Polar Y; Goswami CP; Hoshino T; Qian Y; Sledge GW
  • Splicing factors ESRP1/ESRP2 as regulators of endocrine resistance in breast cancer
    Volume: 74
    10/01/2014 Authors: Gokmen-Polar Y; Nellamraju Y; Gu X; Janga SC; Badve SS
  • DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.
    J Natl Cancer Inst Volume: 106
    07/01/2014 Authors: Woditschka S; Evans L; Duchnowska R; Reed LT; Palmieri D; Qian Y; Badve S; Sledge G; Gril B; Aladjem MI
  • The prognostic value of architectural patterns in a study of 37 type AB thymomas.
    Mod Pathol Volume: 27 Page(s): 863 - 868
    06/01/2014 Authors: Vladislav IT; Gkmen-Polar Y; Kesler KA; Loehrer PJ; Badve S
  • INDUCT: A risk score to predict relapse in estrogen-receptor-positive breast cancer.
    Volume: 32
    05/20/2014 Authors: Buechler S; Badve SS; Gokmen-Polar Y
  • Prognostic ability of CD44 expression in ER-positive breast cancer.
    Volume: 32
    05/20/2014 Authors: Gokmen-Polar Y; Badve SS
  • The Prognostic Value of Architectural Patterns in a Study of 41 Type AB Thymomas
    Volume: 27 Page(s): 497A - 498A
    02/01/2014 Authors: Vladislav IT; Gokmen-Polar Y; Kesler KA; Loehrer PJ; Badve S
  • Type B Thymomas - Relevance of Current Subclassification
    Volume: 27 Page(s): 478A - 478A
    02/01/2014 Authors: Gokmen-Polar Y; Lu W; Kesler K; Loehrer PJ; Badve S
  • HOTAIR Expression in Breast Cancer and Nodal Metastases
    Volume: 27 Page(s): 50A - 50A
    02/01/2014 Authors: Gokmen-Polar Y; Valdislav IT; Sirimalle U; Badve S
  • SF3B1 and SF3B3 Expression in Tamoxifen Resistance
    Volume: 27 Page(s): 50A - 50A
    02/01/2014 Authors: Gokmen-Polar Y; Nellamraju Y; Goswami CP; Gu X; Janga SC; Badve S
  • Type B Thymomas - Relevance of Current Subclassification
    Volume: 94 Page(s): 478A - 478A
    02/01/2014 Authors: Gokmen-Polar Y; Lu W; Kesler K; Loehrer PJ; Badve S
  • The Prognostic Value of Architectural Patterns in a Study of 41 Type AB Thymomas
    Volume: 94 Page(s): 497A - 498A
    02/01/2014 Authors: Vladislav IT; Gokmen-Polar Y; Kesler KA; Loehrer PJ; Badve S
  • HOTAIR Expression in Breast Cancer and Nodal Metastases
    Volume: 94 Page(s): 50A - 50A
    02/01/2014 Authors: Gokmen-Polar Y; Valdislav IT; Sirimalle U; Badve S
  • SF3B1 and SF3B3 Expression in Tamoxifen Resistance
    Volume: 94 Page(s): 50A - 50A
    02/01/2014 Authors: Gokmen-Polar Y; Nellamraju Y; Goswami CP; Gu X; Janga SC; Badve S
  • Multiplexed protein analysis.
    Sci Transl Med Volume: 6 Page(s): 219fs3
    01/15/2014 Authors: Gkmen-Polar Y; Badve S
  • Gene Expression Analysis Reveals Distinct Pathways of Resistance to Bevacizumab in Xenograft Models of Human ER-Positive Breast Cancer.
    J Cancer Volume: 5 Page(s): 633 - 645
    01/01/2014 Authors: Gkmen-Polar Y; Goswami CP; Toroni RA; Sanders KL; Mehta R; Sirimalle U; Tanasa B; Shen C; Li L; Ivan M
  • ESRP1 and ESRP2 expression in tamoxifen resistance
    Volume: 73
    12/15/2013 Authors: Goekmen-Polar Y; Goswami CP; Gu X; Nakshatri H; Badve S
  • FOXP3 expression and nodal metastasis of breast cancer.
    Cell Oncol (Dordr) Volume: 36 Page(s): 405 - 409
    10/01/2013 Authors: Gkmen-Polar Y; Thorat MA; Sojitra P; Saxena R; Badve S
  • A GENE SIGNATURE TO DISTINGUISH THYMIC CARCINOMA FROM THYMOMA
    Volume: 8 Page(s): 36 - 37
    09/01/2013 Authors: Goekmen-Polar Y; Cook R; Wilkinson J; Maetzold D; Stone J; Oelschlager K; Lu W; Vladislav I; Kesler K; Loehrer P
  • PRECLINICAL MODELS FOR THYMIC TUMORS
    Volume: 8 Page(s): 7 - 8
    09/01/2013 Authors: Goekmen-Polar Y
  • The role of histology in predicting recurrence of type A thymomas: a clinicopathologic correlation of 23 cases.
    Mod Pathol Volume: 26 Page(s): 1059 - 1064
    08/01/2013 Authors: Vladislav IT; Gkmen-Polar Y; Kesler KA; Loehrer PJ; Badve S
  • Counterpoint: cancer stem cells: nonbelievers' viewpoint.
    Clin Chem Volume: 59 Page(s): 208 - 210
    01/01/2013 Authors: Gkmen-Polar Y; Badve SS
  • A gene signature to determine metastatic behavior in thymomas.
    PLoS One Volume: 8 Page(s): e66047
    01/01/2013 Authors: Gkmen-Polar Y; Cook RW; Goswami CP; Wilkinson J; Maetzold D; Stone JF; Oelschlager KM; Vladislav IT; Shirar KL; Kesler KA
  • Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models.
    Breast Cancer Res Treat Volume: 136 Page(s): 673 - 682
    12/01/2012 Authors: Gkmen-Polar Y; Liu Y; Toroni RA; Sanders KL; Mehta R; Badve S; Rommel C; Sledge GW
  • A 19-GENE PROGNOSTIC GEP SIGNATURE TO DETERMINE METASTATIC RISK ASSOCIATED WITH THYMOMAS
    Volume: 7 Page(s): S422 - S422
    11/01/2012 Authors: Gokmen-Polar Y; Cook RW; Goswami CP; Oelschlager KM; Maetzold D; Stone J; Wilkinson J; Vladislav IT; Shirar KL; Kesler KA
  • Establishment and characterization of a novel cell line derived from human thymoma AB tumor.
    Lab Invest Volume: 92 Page(s): 1564 - 1573
    11/01/2012 Authors: Gkmen-Polar Y; Sanders KL; Goswami CP; Cano OD; Zaheer NA; Jain RK; Kesler KA; Nelson RP; Vance GH; Smith D
  • A 19-gene prognostic GEP signature to determine metastatic risk associated with thymomas
    Volume: 30
    10/20/2012 Authors: Gokmen-Polar Y; Goswami CP; Cook RW; Oelschlager KM; Maetzold D; Vladislav IT; Shirar KL; Kesler K; Loehrer PJ; Badve SS
  • Breast cancer prognostic markers: where are we now?
    MLO Med Lab Obs Volume: 44 Page(s): 22 - 25
    09/01/2012 Authors: Gkmen-Polar Y; Badve S
  • In silico identification of an epithelial core signature in human tumors
    Volume: 30
    05/20/2012 Authors: Goswami CP; Cano OD; Gokmen-Polar Y; Badve SS
  • A 19-gene prognostic GEP signature (DecisionDx-Thymoma) to determine metastatic risk associated with thymomas.
    Volume: 30
    05/20/2012 Authors: Gokmen-Polar Y; Goswami CP; Cook RW; Oelschlager KM; Maetzold D; Vladislav IT; Shirar KL; Kesler K; Loehrer PJ; Badve SS
  • 13-gene signature to predict rapid development of brain metastases in patients with HER2-positive advanced breast cancer
    Volume: 30
    05/20/2012 Authors: Duchnowska R; Jassem J; Goswami CP; Gokmen-Polar Y; Li L; Thorat MA; Flores N; Hua E; Woditschka S; Palmieri D
  • Identification of transcriptional regulatory motifs that control gene expression in premenopausal women with previous history of breast cancer
    Volume: 72
    04/15/2012 Authors: Cano OD; Gokmen-Polar Y; Chirayu G; Li L; Sirimalle U; Gu X; Nakshatri H; Badve S
  • Molecular profiling assays in breast cancer: are we ready for prime time?
    Oncology (Williston Park) Volume: 26 Page(s): 350 - 361
    04/01/2012 Authors: Gkmen-Polar Y; Badve S
  • Extrathoracic metastases of thymic origin: a review of 35 cases.
    Mod Pathol Volume: 25 Page(s): 370 - 377
    03/01/2012 Authors: Vladislav T; Jain RK; Alvarez R; Mehta RJ; Gkmen-Polar Y; Kesler KA; Henley JD; Loehrer PJ; Badve S
  • Mixed Small Cell Undifferentiated Squamous Cell Carcinoma of the Thymus - A Clinicopathologic Study of 10 Cases
    Volume: 25 Page(s): 472A - 472A
    02/01/2012 Authors: Badve S; Cano O; Gokmen-Polar Y; Kesler K; Loehrer P; Badve S
  • Mixed Small Cell Undifferentiated Squamous Cell Carcinoma of the Thymus - Clinicopathologic Study of 10 Cases
    Volume: 92 Page(s): 472A - 472A
    02/01/2012 Authors: Badve S; Cano O; Gokmen-Polar Y; Kesler K; Loehrer P; Badve S
  • Molecular analysis of thymoma.
    PLoS One Volume: 7 Page(s): e42669
    01/01/2012 Authors: Badve S; Goswami C; Gkmen-Polar Y; Nelson RP; Henley J; Miller N; Zaheer NA; Sledge GW; Li L; Kesler KA
  • Gene Expression Analysis of Resistance to Bevacizumab in a VEGF-Reinforced Xenograft Model of ER-Positive Breast Cancer.
    Volume: 71
    12/15/2011 Authors: Gokmen-Polar Y; Toroni RA; Goswami C; Sanders KL; Mehta R; Sirimalle U; Tanasa B; Shen C; Li L; Ivan M
  • Gene Profiling of Whole Blood May Identify Patients with BRCA Mutations.
    Volume: 71
    12/15/2011 Authors: Mina LA; Gokmen-Polar Y; Goswami C; Storniolo AM; Li L; Badve S; Sledge GW
  • Bevacizumab Treatment Alters Intrinsic Subtypes in a VEGF-Reinforced Xenograft Model of ER-Positive Breast Cancer.
    Volume: 71
    12/15/2011 Authors: Gokmen-Polar Y; Toroni RA; Goswami C; Sanders KL; Sirimalle U; Mehta R; Li L; Ivan M; Badve S; Sledge GW
  • Biomarkers for breast cancer stem cells: the challenges ahead.
    Biomark Med Volume: 5 Page(s): 661 - 671
    10/01/2011 Authors: Gkmen-Polar Y; Nakshatri H; Badve S
  • Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer.
    Breast Cancer Res Treat Volume: 127 Page(s): 375 - 384
    06/01/2011 Authors: Gkmen-Polar Y; Toroni RA; Hocevar BA; Badve S; Zhao Q; Shen C; Bruckheimer E; Kinch MS; Miller KD
  • RAD51 and brain metastases (BM) in patients (pts) with HER2+breast cancer
    Volume: 29
    05/20/2011 Authors: Duchnowska R; Jassem J; Szutowicz E; Biernat W; Jankowski T; Och W; Staszkiewicz R; Chudzik M; Rogowski W; Flores N
  • In silico analysis of angiogenesis pathway as a prognostic tool in breast cancer
    Volume: 71
    04/15/2011 Authors: Mehta RJ; Jain RK; Gokmen-Polar Y; Badve S
  • Study of Concordance between RT-PCR and Immunohistochemical Testing of Hormone Receptor and HER2 Status in Breast Cancer Specimens.
    Volume: 24 Page(s): 54A - 54A
    02/01/2011 Authors: Mehta R; Jain RK; Sojitra PM; Gokmen-Polar Y; Badve S
  • Study of Concordance between RT-PCR and Immunohistochemical Testing of Hormone Receptor and HER2 Status in Breast Cancer Specimens
    Volume: 91 Page(s): 54A - 54A
    02/01/2011 Authors: Mehta R; Jain RK; Sojitra PM; Gokmen-Polar Y; Badve S
  • Tumor marker assessment: points to ponder.
    Cancer Biol Ther Volume: 11 Page(s): 284 - 286
    01/15/2011 Authors: Gkmen-Polar Y; Badve S
  • Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes.
    Breast Cancer Res Treat Volume: 124 Page(s): 327 - 335
    11/01/2010 Authors: Gkmen-Polar Y; Mehta R; Tuzmen S; Mousses S; Thorat MA; Sanders KL; Turbin D; Leung S; Huntsman DG; Sledge GW
  • Promise of computational systems biology for cancer clinical trials: the voyage to be realized?
    Per Med Volume: 7 Page(s): 129 - 131
    03/01/2010 Authors: Gkmen-Polar Y; Badve S
  • Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer
    Volume: 69 Page(s): 210S - 211S
    01/15/2009 Authors: Gokmen-Polar Y; Toroni RA; Badve S; Bruckheimer E; Kinch MS; Miller KD
  • Redefining the target again: chemotherapeutics as vascular disrupting agents?
    Cancer Cell Volume: 14 Page(s): 195 - 196
    09/09/2008 Authors: Gokmen-Polar Y; Miller KD
  • 2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells.
    Cancer Res Volume: 67 Page(s): 702 - 708
    01/15/2007 Authors: Bhati R; Gkmen-Polar Y; Sledge GW; Fan C; Nakshatri H; Ketelsen D; Borchers CH; Dial MJ; Patterson C; Klauber-DeMore N
  • A comparative proteomic study to characterize the vinblastine resistance in human ovarian cancer cells.
    Proteomics Clin Appl Volume: 1 Page(s): 18 - 31
    01/01/2007 Authors: Brown DPG; Gkmen-Polar Y; Jiang L; Tan J; Ringham H; Janecki DJ; Qi G; Witzmann FA; Sledge GW; Wang M
  • Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model.
    Prostate Volume: 66 Page(s): 1498 - 1511
    10/01/2006 Authors: Shanmugam R; Jayaprakasan V; Gokmen-Polar Y; Kelich S; Miller KD; Yip-Schneider M; Cheng L; Bhat-Nakshatri P; Sledge GW; Nakshatri H
  • Protein kinase C-beta as a therapeutic target in breast cancer.
    Semin Oncol Volume: 33 Page(s): S15 - S18
    06/01/2006 Authors: Sledge GW; Gkmen-Polar Y
  • 2-Methoxyestradiol-resistant cancer cells overexpress functional laminin alpha 4
    Volume: 66
    04/01/2006 Authors: Gokmen-Polar Y; Sanders KL; Jones JCR; Nakshatri H; Sledge GW
  • beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.
    Cancer Res Volume: 65 Page(s): 9406 - 9414
    10/15/2005 Authors: Gkmen-Polar Y; Escuin D; Walls CD; Soule SE; Wang Y; Sanders KL; Lavallee TM; Wang M; Guenther BD; Giannakakou P
  • Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo.
    J Cell Biol Volume: 164 Page(s): 797 - 802
    03/15/2004 Authors: Murray NR; Jamieson L; Yu W; Zhang J; Gkmen-Polar Y; Sier D; Anastasiadis P; Gatalica Z; Thompson EA; Fields AP
  • EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity.
    Cancer Res Volume: 63 Page(s): 3425 - 3429
    06/15/2003 Authors: Lu M; Miller KD; Gokmen-Polar Y; Jeng M-H; Kinch MS
  • Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.
    Cancer Res Volume: 61 Page(s): 1375 - 1381
    02/15/2001 Authors: Gkmen-Polar Y; Murray NR; Velasco MA; Gatalica Z; Fields AP
  • Mapping of a molecular determinant for protein kinase C betaII isozyme function.
    J Biol Chem Volume: 273 Page(s): 20261 - 20266
    08/07/1998 Authors: Gkmen-Polar Y; Fields AP
  • Wortmannin converts insulin but not oxytocin from an antilipolytic to a lipolytic agent in the presence of forskolin.
    Metabolism Volume: 46 Page(s): 62 - 66
    01/01/1997 Authors: Fain JN; Gokmen-Polar Y; Bahouth SW
  • Mutations associated with hemophilia B in Turkish patients.
    Hum Mutat Volume: 10 Page(s): 76 - 79
    01/01/1997 Authors: Calayan SH; Gkmen Y; Aktulu G; Grgey A; Sommer SS
  • Enhanced desensitization and phosphorylation of the beta 1-adrenergic receptor in rat adipocytes by peroxovanadate.
    Mol Pharmacol Volume: 49 Page(s): 1049 - 1057
    06/01/1996 Authors: Bahouth SW; Gokmen-Polar Y; Coronel EC; Fain JN
  • Inhibition by NMDA of carbachol-stimulated inositol tetrakisphosphate accumulation in rat brain cortical slices.
    Neuropharmacology Volume: 35 Page(s): 415 - 421
    04/01/1996 Authors: Myles ME; Gokmen-Polar Y; Fain JN
  • Insulin sensitizes beta-agonist and forskolin-stimulated lipolysis to inhibition by 2',5'-dideoxyadenosine.
    Am J Physiol Volume: 270 Page(s): C562 - C569
    02/01/1996 Authors: Gokmen-Polar Y; Coronel EC; Bahouth SW; Fain JN
  • Inhibition by veratridine of carbachol-stimulated inositol tetrakisphosphate accumulation in rat brain cortical slices.
    Neurochem Res Volume: 20 Page(s): 1057 - 1064
    09/01/1995 Authors: Myles ME; Gokmen-Polar Y; Fain JN
  • Polymorphisms associated with the FVIII and FIX genes in the Turkish population.
    Haemophilia Volume: 1 Page(s): 184 - 189
    07/01/1995 Authors: Calayan SH; Gkmen Y; Kirdar B
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