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Profile

Ling Ye PhD

  • Department of Microbiology and Immunology
    Assistant Professor
  • (404) 727-6558
  • yling@emory.edu
  • Emory University School of Medicine
    Microbiology and Immunology
    1510 Clifton Rd., Room 3086 RRC
Head shot of Ling Ye

Overview

The main focus of my research interest is to design novel vaccine strategies for eliciting broadly neutralizing antibodies against HIV. In particular, we have constructed a chimeric protein, HA/gp41, by fusing the HIV Env gp41 in frame to the C-terminus of the HA1 subunit of an influenza virus hemagglutinin. The HA/gp41 is efficiently transported to the cell surfaces, exhibits enhanced reactivity to monoclonal antibodies 2F5 and 4E10, and more effectively induces gp41-specific antibodies compared to the HIV Env. Recently, we further evaluated the immunogenicity of HA/gp41-based DNA or virus-like particle (VLP) vaccines in guinea pigs and found that immunization with HA/gp41 DNA or VLP vaccines induced neutralizing antibodies against the conserved epitopes in gp41. Currently, we are evaluating the effectiveness of this chimeric protein vaccine in small animal models, with the goal to improve its design for optimizing its ability to induce broadly HIV neutralizing antibodies. In addition to HIV vaccine development, we are also investigating the role of regulatory T cells in modulating vaccine-induced immune responses in aging host using the mouse model.

Academic Appointment

  • Assistant Professor, Department of Microbiology and Immunology, Emory University School of Medicine

Education

Degrees

  • MD, PhD from Fourth Military Medical University
  • M.S. from Shanxi Medical University
  • BS from Shanxi Medical University

Research

Focus

  • My research interests center on developing virus-like particle vaccines against virus infection. Currently, we are investigating the potential of incorporating immune stimulating molecules to enhance immunogenicities of virus-like particles and modification of viral glycoproteins to improve their antigenicities for obtaining more effective vaccines against HIV, Ebola virus, influenza virus, and hepatitis C virus.

Publications

  • An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination.
    Proc Natl Acad Sci U S A Volume: 118
    11/09/2021 Authors: Xia D; Jin R; Byagathvalli G; Yu H; Ye L; Lu C-Y; Bhamla MS; Yang C; Prausnitz MR
  • Intradermal Immunization of EBOV VLPs in Guinea Pigs Induces Broader Antibody Responses Against GP Than Intramuscular Injection.
    Front Microbiol Volume: 11 Page(s): 304
    01/01/2020 Authors: Liu Y; Wen Z; Carrion R; Nunneley J; Staples H; Ticer A; Patterson JL; Compans RW; Ye L; Yang C
  • Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota.
    Pharmacol Res Volume: 148 Page(s): 104403
    10/01/2019 Authors: Chen R; Xu Y; Wu P; Zhou H; Lasanajak Y; Fang Y; Tang L; Ye L; Li X; Cai Z
  • Intradermal Vaccination With Adjuvanted Ebola Virus Soluble Glycoprotein Subunit Vaccine by Microneedle Patches Protects Mice Against Lethal Ebola Virus Challenge.
    J Infect Dis Volume: 218 Page(s): S545 - S552
    11/22/2018 Authors: Liu Y; Ye L; Lin F; Gomaa Y; Flyer D; Carrion R; Patterson JL; Prausnitz MR; Smith G; Glenn G
  • Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.
    Sci Rep Volume: 8 Page(s): 11193
    07/25/2018 Authors: Liu Y; Ye L; Lin F; Gomaa Y; Flyer D; Carrion R; Patterson JL; Prausnitz MR; Smith G; Glenn G
  • Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice.
    Microbes Infect Volume: 19 Page(s): 626 - 634
    12/01/2017 Authors: Wen Z; Wang X; Dong K; Zhang H; Bu Z; Ye L; Yang C
  • Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection.
    Sci Rep Volume: 6 Page(s): 32161
    08/26/2016 Authors: Wang C; Li X; Yu F; Lu L; Jiang X; Xu X; Wang H; Lai W; Zhang T; Zhang Z
  • An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene.
    Emerg Microbes Infect Volume: 5 Page(s): e65
    06/22/2016 Authors: Sun Z; Zhu Y; Wang Q; Ye L; Dai Y; Su S; Yu F; Ying T; Yang C; Jiang S
  • Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
    Sci Rep Volume: 6 Page(s): 24897
    04/25/2016 Authors: Dye JM; Wu H; Hooper JW; Khurana S; Kuehne AI; Coyle EM; Ortiz RA; Fuentes S; Herbert AS; Golding H
  • Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches.
    Pharm Res Volume: 33 Page(s): 868 - 878
    04/01/2016 Authors: Chu LY; Ye L; Dong K; Compans RW; Yang C; Prausnitz MR
  • Characterization of Immune Responses Induced by Ebola Virus Glycoprotein (GP) and Truncated GP Isoform DNA Vaccines and Protection Against Lethal Ebola Virus Challenge in Mice.
    J Infect Dis Volume: 212 Suppl 2 Page(s): S398 - S403
    10/01/2015 Authors: Li W; Ye L; Carrion R; Mohan GS; Nunneley J; Staples H; Ticer A; Patterson JL; Compans RW; Yang C
  • Development of vaccines for prevention of Ebola virus infection.
    Microbes Infect Volume: 17 Page(s): 98 - 108
    02/01/2015 Authors: Ye L; Yang C
  • Less is more: Ebola virus surface glycoprotein expression levels regulate virus production and infectivity.
    J Virol Volume: 89 Page(s): 1205 - 1217
    01/15/2015 Authors: Mohan GS; Ye L; Li W; Monteiro A; Lin X; Sapkota B; Pollack BP; Compans RW; Yang C
  • Autophagy is essential for effector CD8(+) T cell survival and memory formation.
    Nat Immunol Volume: 15 Page(s): 1152 - 1161
    12/01/2014 Authors: Xu X; Araki K; Li S; Han J-H; Ye L; Tan WG; Konieczny BT; Bruinsma MW; Martinez J; Pearce EL
  • Identification of novel markers for mouse CD4(+) T follicular helper cells.
    Eur J Immunol Volume: 43 Page(s): 3219 - 3232
    12/01/2013 Authors: Iyer SS; Latner DR; Zilliox MJ; McCausland M; Akondy RS; Penaloza-Macmaster P; Hale JS; Ye L; Mohammed A-U-R; Yamaguchi T
  • Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.
    J Virol Volume: 87 Page(s): 7737 - 7746
    07/01/2013 Authors: Rasheed MAU; Latner DR; Aubert RD; Gourley T; Spolski R; Davis CW; Langley WA; Ha S-J; Ye L; Sarkar S
  • Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.
    Immunity Volume: 38 Page(s): 805 - 817
    04/18/2013 Authors: Hale JS; Youngblood B; Latner DR; Mohammed AUR; Ye L; Akondy RS; Wu T; Iyer SS; Ahmed R
  • mTOR, linking metabolism and immunity.
    Semin Immunol Volume: 24 Page(s): 429 - 435
    12/01/2012 Authors: Xu X; Ye L; Araki K; Ahmed R
  • Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.
    Proc Natl Acad Sci U S A Volume: 109 Page(s): 9965 - 9970
    06/19/2012 Authors: Wu T; Wieland A; Araki K; Davis CW; Ye L; Hale JS; Ahmed R
  • Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus.
    PLoS Pathog Volume: 8 Page(s): e1003065
    01/01/2012 Authors: Mohan GS; Li W; Ye L; Compans RW; Yang C
  • Characterization of immune responses induced by immunization with the HA DNA vaccines of two antigenically distinctive H5N1 HPAIV isolates.
    PLoS One Volume: 7 Page(s): e41332
    01/01/2012 Authors: Gao Y; Wen Z; Dong K; Zhong G; Wang X; Bu Z; Chen H; Ye L; Yang C
  • Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.
    Proc Natl Acad Sci U S A Volume: 108 Page(s): 21182 - 21187
    12/27/2011 Authors: Aubert RD; Kamphorst AO; Sarkar S; Vezys V; Ha S-J; Barber DL; Ye L; Sharpe AH; Freeman GJ; Ahmed R
  • Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines.
    PLoS One Volume: 6 Page(s): e14813
    01/01/2011 Authors: Ye L; Wen Z; Dong K; Wang X; Bu Z; Zhang H; Compans RW; Yang C
  • Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine.
    Vaccine Volume: 28 Page(s): 4103 - 4112
    05/28/2010 Authors: Skountzou I; Martin MDP; Wang B; Ye L; Koutsonanos D; Weldon W; Jacob J; Compans RW
  • Corrigendum to "Protection against lethal challenge by Ebola virus-like particles produced in insect cells" [Virology 383 (2009) 12-21].
    Virology Volume: 399 Page(s): 186
    03/30/2010 Authors: Sun Y; Carrion R; Ye L; Wen Z; Ro Y-T; Brasky K; Ticer AE; Schwegler EE; Patterson JL; Compans RW
  • Immunization with a Mixture of HIV Env DNA and VLP Vaccines Augments Induction of CD8 T Cell Responses.
    J Biomed Biotechnol Volume: 2010 Page(s): 497219
    01/01/2010 Authors: Ye L; Wen Z; Dong K; Pan L; Bu Z; Compans RW; Zhang H; Yang C
  • Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge.
    Antiviral Res Volume: 84 Page(s): 215 - 224
    12/01/2009 Authors: Wen Z; Ye L; Gao Y; Pan L; Dong K; Bu Z; Compans RW; Yang C
  • Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge.
    Proc Natl Acad Sci U S A Volume: 106 Page(s): 7968 - 7973
    05/12/2009 Authors: Zhu Q; Zarnitsyn VG; Ye L; Wen Z; Gao Y; Pan L; Skountzou I; Gill HS; Prausnitz MR; Yang C
  • Protection against lethal challenge by Ebola virus-like particles produced in insect cells.
    Virology Volume: 383 Page(s): 12 - 21
    01/05/2009 Authors: Sun Y; Carrion R; Ye L; Wen Z; Ro Y-T; Brasky K; Ticer AE; Schwegler EE; Patterson JL; Compans RW
  • Protection against filovirus infection: virus-like particle vaccines.
    Expert Rev Vaccines Volume: 7 Page(s): 333 - 344
    04/01/2008 Authors: Yang C; Ye L; Compans RW
  • Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles.
    J Virol Volume: 81 Page(s): 10869 - 10878
    10/01/2007 Authors: Wang B-Z; Liu W; Kang S-M; Alam M; Huang C; Ye L; Sun Y; Li Y; Kothe DL; Pushko P
  • Incorporation of glycosylphosphatidylinositol-anchored granulocyte- macrophage colony-stimulating factor or CD40 ligand enhances immunogenicity of chimeric simian immunodeficiency virus-like particles.
    J Virol Volume: 81 Page(s): 1083 - 1094
    02/01/2007 Authors: Skountzou I; Quan F-S; Gangadhara S; Ye L; Vzorov A; Selvaraj P; Jacob J; Compans RW; Kang S-M
  • Antigenic properties of a transport-competent influenza HA/HIV Env chimeric protein.
    Virology Volume: 352 Page(s): 74 - 85
    08/15/2006 Authors: Ye L; Sun Y; Lin J; Bu Z; Wu Q; Jiang S; Steinhauer DA; Compans RW; Yang C
  • Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies.
    Virology Volume: 351 Page(s): 260 - 270
    08/01/2006 Authors: Ye L; Lin J; Sun Y; Bennouna S; Lo M; Wu Q; Bu Z; Pulendran B; Compans RW; Yang C
  • Chimeric influenza virus hemagglutinin proteins containing large domains of the Bacillus anthracis protective antigen: protein characterization, incorporation into infectious influenza viruses, and antigenicity.
    J Virol Volume: 79 Page(s): 10003 - 10012
    08/01/2005 Authors: Li Z-N; Mueller SN; Ye L; Bu Z; Yang C; Ahmed R; Steinhauer DA
  • Modified HIV envelope proteins with enhanced binding to neutralizing monoclonal antibodies.
    Virology Volume: 331 Page(s): 20 - 32
    01/05/2005 Authors: Kang S-M; Quan FS; Huang C; Guo L; Ye L; Yang C; Compans RW
  • Surface stability and immunogenicity of the human immunodeficiency virus envelope glycoprotein: role of the cytoplasmic domain.
    J Virol Volume: 78 Page(s): 13409 - 13419
    12/01/2004 Authors: Ye L; Bu Z; Vzorov A; Taylor D; Compans RW; Yang C
  • Enhancement of immunogenicity of an HIV Env DNA vaccine by mutation of the Tyr-based endocytosis motif in the cytoplasmic domain.
    Virology Volume: 328 Page(s): 62 - 73
    10/10/2004 Authors: Bu Z; Ye L; Vzorov A; Taylor D; Compans RW; Yang C
  • Enhanced immunogenicity of SIV Gag DNA vaccines encoding chimeric proteins containing a C-terminal segment of Listeriolysin O.
    Virus Res Volume: 97 Page(s): 7 - 16
    11/01/2003 Authors: Ye L; Bu Z; Skeen MJ; Ziegler HK; Compans RW; Yang C
  • Enhanced cellular immune response against SIV Gag induced by immunization with DNA vaccines expressing assembly and release-defective SIV Gag proteins.
    Virology Volume: 309 Page(s): 272 - 281
    05/10/2003 Authors: Bu Z; Ye L; Compans RW; Yang C
  • Enhancement of immune responses to an HIV env DNA vaccine by a C-terminal segment of listeriolysin O.
    AIDS Res Hum Retroviruses Volume: 19 Page(s): 409 - 420
    05/01/2003 Authors: Bu Z; Ye L; Skeen MJ; Ziegler HK; Compans RW; Yang C
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