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Profile

Yoke Kow PhD

  • Department of Radiation Oncology
    Professor Emeritus
  • (404) 778-5481
  • ykow@emory.edu
Head shot of Yoke Kow

Overview

Dr. Yoke Wah Kow retired from Emory in 2014 after 19 years of service at Emory. Dr. Kow was an outstanding teacher, researcher and role model in the Department of Radiation Oncology.

Dr. Kow received his PhD from Brandeis University in Waltham, Massachusetts. He received his BS at Nanyang Technological University in Singapore. Dr. Kow completed his training as a research associate in the Department of Biochemistry at the University of Wisconsin in Madison, Wisconsin.

Academic Appointment

Education

Degrees

  • PhD from Brandeis University
  • BS from Nanyang University

Research

Focus

  • My research focus is on DNA damage and repair for the last 25 years. In the last three years, my laboratory is focus on the role of clustered DNA damage in the formation of the codon 599 mutation of BRAF gene, a most commonly observed mutation in sporadic melanoma.

Publications

  • Replicative DNA polymerase but not proofreads errors in Cis and in Trans.
    PLoS Genet Volume: 11 Page(s): e1005049
    03/01/2015 Authors: Flood CL; Rodriguez GP; Bao G; Shockley AH; Kow YW; Crouse GF
  • The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity.
    J Mol Biol Volume: 426 Page(s): 3703 - 3712
    11/11/2014 Authors: Hong S; Hashimoto H; Kow YW; Zhang X; Cheng X
  • Repair efficiency of (5'S)-8,5'-cyclo-2'-deoxyguanosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine depends on the complementary base.
    DNA Repair (Amst) Volume: 11 Page(s): 926 - 931
    11/01/2012 Authors: Pande P; Das RS; Sheppard C; Kow YW; Basu AK
  • Saccharomyces cerevisiae Apn1 mutation affecting stable protein expression mimics catalytic activity impairment: implications for assessing DNA repair capacity in humans.
    DNA Repair (Amst) Volume: 11 Page(s): 753 - 765
    09/01/2012 Authors: Morris LP; Degtyareva N; Sheppard C; Heyburn L; Ivanov AA; Kow YW; Doetsch PW
  • Human endonuclease V as a repair enzyme for DNA deamination.
    Mutat Res Volume: 735 Page(s): 12 - 18
    07/01/2012 Authors: Mi R; Alford-Zappala M; Kow YW; Cunningham RP; Cao W
  • Effect of sequence context and direction of replication on AP site bypass in Saccharomyces cerevisiae.
    Mutat Res Volume: 669 Page(s): 147 - 154
    10/02/2009 Authors: Bao G; Kow YW
  • Escherichia coli HU protein has a role in the repair of abasic sites in DNA.
    Nucleic Acids Res Volume: 35 Page(s): 6672 - 6680
    01/01/2007 Authors: Kow YW; Imhoff B; Weiss B; Hung DCI; Hindoyan AA; Story RM; Goodman SD
  • Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae.
    Nucleic Acids Res Volume: 33 Page(s): 6196 - 6202
    01/01/2005 Authors: Kow YW; Bao G; Minesinger B; Jinks-Robertson S; Siede W; Jiang YL; Greenberg MM
  • Repair of deaminated bases in DNA.
    Free Radic Biol Med Volume: 33 Page(s): 886 - 893
    10/01/2002 Authors: Kow YW
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