Yun Kang
- Department of Human Genetics
Instructor
-
Emory University School of Medicine
Human Genetics
615 Michael street
Overview
As a neurobiologist with decades of dedicated research since 2000, my expertise centers on unraveling the complex mechanisms underlying various neurodevelopmental, neurological, and neurodegenerative conditions including autism, epilepsy, Fragile X syndrome (FXS), Fragile X-associated tremor/ataxia syndrome (FXTAS) and Neuronal Intranuclear Inclusion Disease (NIID). A significant aspect of my work involves the creation and implementation of innovative research tools such as tandem affinity purification and mass spectrometry strategy and human iPSC derived brain organoids of FXS and FXTAS. These advancements have enabled more precise investigations into the pathogenesis of neurological disorders, facilitating a deeper understanding of their molecular and cellular underpinnings to advance the field. Through collaborative efforts and interdisciplinary research, I continue to push the boundaries of our understanding, always with the ultimate goal of improving the lives of those affected by these challenging neurological conditions. My research expertise spans multiple disciplines, encompassing neurodevelopment, neurological disorders, and cutting-edge molecular techniques such as epitranscriptomics, proteomics, single-cell RNAseq, single-nuclei RNAseq and eCLIP-seq, along with bioinformatics.
Education
Degrees
- PhD from Korea University
Research
Publications
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ETV2/ER71 regulates hematovascular lineage generation and vascularization through an H3K9 demethylase, KDM4A.
iScience Volume: 28 Page(s): 111538
01/17/2025 Authors: Kim MS; Lee R; Lee DH; Song H; Ha T; Kim JK; Kang B-Y; Agger K; Helin K; Shin D -
Stem Cell-Derived Organoids.
Stem Cells Int Volume: 2024 Page(s): 9798375
01/01/2024 Authors: Li Y; Li X; Kang Y; Jiang S -
FMRP phosphorylation modulates neuronal translation through YTHDF1.
Mol Cell Volume: 83 Page(s): 4304 - 4317.e8
12/07/2023 Authors: Zou Z; Wei J; Chen Y; Kang Y; Shi H; Yang F; Shi Z; Chen S; Zhou Y; Sepich-Poore C -
Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals.
Cells Volume: 12
02/27/2023 Authors: Cencelli G; Pacini L; De Luca A; Messia I; Gentile A; Kang Y; Nobile V; Tabolacci E; Jin P; Farace MG -
Expression of expanded GGC repeats within NOTCH2NLC causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease.
Sci Adv Volume: 8 Page(s): eadd6391
11/25/2022 Authors: Liu Q; Zhang K; Kang Y; Li Y; Deng P; Li Y; Tian Y; Sun Q; Tang Y; Xu K -
Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome.
Proc Natl Acad Sci U S A Volume: 119 Page(s): e2118124119
05/31/2022 Authors: Kong HE; Lim J; Linsalata A; Kang Y; Malik I; Allen EG; Cao Y; Shubeck L; Johnston R; Huang Y -
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
Nat Neurosci Volume: 24 Page(s): 1377 - 1391
10/01/2021 Authors: Kang Y; Zhou Y; Li Y; Han Y; Xu J; Niu W; Li Z; Liu S; Feng H; Huang W -
Ten-eleven translocation protein 1 modulates medulloblastoma progression.
Genome Biol Volume: 22 Page(s): 125
04/29/2021 Authors: Kim H; Kang Y; Li Y; Chen L; Lin L; Johnson ND; Zhu D; Robinson MH; McSwain L; Barwick BG -
The Potential Contribution of Fortified Maize Flour, Oil, Rice, Salt, and Wheat Flour to Estimated Average Requirements and Tolerable Upper Intake Levels for 15 Nutrients in 153 Countries.
Nutrients Volume: 13
02/09/2021 Authors: Pachn H; Reynolds B; Duong M; Tsang BL; Childs L; Luthringer CL; Kang Y; Vasta FC; Codling K -
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease.
Genome Biol Volume: 22 Page(s): 17
01/05/2021 Authors: Shafik AM; Zhang F; Guo Z; Dai Q; Pajdzik K; Li Y; Kang Y; Yao B; Wu H; He C