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Profile

Yue Feng PhD

  • Department of Pharmacology & Chemical Biology
    Professor
  • (404) 727-0351
  • yfeng@emory.edu
  • Lab Website
  • Emory University School of Medicine
    Pharmacology
    1510 Clifton Rd, Room 5025
Head shot of Yue Feng

Overview

We are interested in how RNA-binding proteins and non-coding RNAs govern normal brain development and function, and how posttranscriptional dysregulation at the steps of mRNA biogenesis, stability, and translation may lead to malfunction of neurons and glia in mental and neurological diseases. Taking a multidisciplinary strategy and a combination of molecular, cellular, genetics and pharmacological approaches, our current research focuses on the following directions:

Regulation and function of the human neuronal and glial non-coding transcriptome in neurological and psychiatric diseases
Molecular mechanisms underlying myelination ad repair
Translational control in neuronal development, synaptic plasticity and brain disorders

Academic Appointment

  • Professor with tenure, Department of Pharmacology, Emory University

Education

Degrees

  • PhD from Vanderbilt University
  • MD from Beijing Medical University

Research

Focus

  • To elucidate how selective RNA-binding proteins and microRNAs control mRNA homeostasis and translation to govern normal function and development of the central nervous system, and how dysregulation at these posttranscriptional steps leads to myelin disorders and mental impairment.

Publications

  • Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.
    Genome Med Volume: 16 Page(s): 129
    11/11/2024 Authors: Wang F; Li Y; Shen H; Martinez-Feduchi P; Ji X; Teng P; Krishnakumar S; Hu J; Chen L; Feng Y
  • Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration.
    J Biol Chem Volume: 300 Page(s): 107595
    08/01/2024 Authors: Zakutansky PM; Ku L; Zhang G; Shi L; Li Y; Yao B; Bassell GJ; Read RD; Feng Y
  • The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
    Brain Behav Immun Volume: 112 Page(s): 175 - 187
    08/01/2023 Authors: Teng P; Li Y; Ku L; Wang F; Goldsmith DR; Wen Z; Yao B; Feng Y
  • The Long Non-Coding RNA GOMAFU in Schizophrenia: Function, Disease Risk, and Beyond.
    Cells Volume: 11
    06/17/2022 Authors: Zakutansky PM; Feng Y
  • Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation.
    Genome Biol Volume: 23 Page(s): 48
    02/07/2022 Authors: Li Y; Wang F; Teng P; Ku L; Chen L; Feng Y; Yao B
  • Multifaceted Regulation of MicroRNA Biogenesis: Essential Roles and Functional Integration in Neuronal and Glial Development.
    Int J Mol Sci Volume: 22
    06/23/2021 Authors: Suster I; Feng Y
  • Novel roles of an intragenic G-quadruplex in controlling microRNA expression and cardiac function.
    Nucleic Acids Res Volume: 49 Page(s): 2522 - 2536
    03/18/2021 Authors: Zhu M; Gao J; Lin X-J; Gong Y-Y; Qi Y-C; Ma Y-L; Song Y-X; Tan W; Li F-Y; Ye M
  • Carbamazepine Restores Neuronal Signaling, Protein Synthesis, and Cognitive Function in a Mouse Model of Fragile X Syndrome.
    Int J Mol Sci Volume: 21
    12/07/2020 Authors: Ding Q; Zhang F; Feng Y; Wang H
  • Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model.
    Commun Biol Volume: 3 Page(s): 127
    03/16/2020 Authors: Ding Q; Sethna F; Wu X-T; Miao Z; Chen P; Zhang Y; Xiao H; Feng W; Feng Y; Li X
  • Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca2+ Entry and Release.
    eNeuro Volume: 7
    01/01/2020 Authors: Rui Y; Pollitt SL; Myers KR; Feng Y; Zheng JQ
  • IL-18 cleavage triggers cardiac inflammation and fibrosis upon -adrenergic insult.
    Eur Heart J Volume: 39 Page(s): 60 - 69
    01/01/2018 Authors: Xiao H; Li H; Wang J-J; Zhang J-S; Shen J; An X-B; Zhang C-C; Wu J-M; Song Y; Wang X-Y
  • Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development.
    Transl Psychiatry Volume: 7 Page(s): 1293
    12/18/2017 Authors: Chen X; Ku L; Mei R; Liu G; Xu C; Wen Z; Zhao X; Wang F; Xiao L; Feng Y
  • Active Cdk5 Immunoprecipitation and Kinase Assay.
    Bio Protoc Volume: 7
    07/05/2017 Authors: Bankston AN; Ku L; Feng Y
  • Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.
    Nat Commun Volume: 8 Page(s): 14359
    02/20/2017 Authors: Sethna F; Feng W; Ding Q; Robison AJ; Feng Y; Wang H
  • Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase.
    Oncogene Volume: 35 Page(s): 5807 - 5816
    11/03/2016 Authors: Xu K; Wang L; Feng W; Feng Y; Shu H-K
  • p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses.
    J Neurosci Volume: 36 Page(s): 11283 - 11294
    11/02/2016 Authors: Li W; Allen ME; Rui Y; Ku L; Liu G; Bankston AN; Zheng JQ; Feng Y
  • Oligodendroglial defects during quakingviable cerebellar development.
    Dev Neurobiol Volume: 76 Page(s): 972 - 982
    09/01/2016 Authors: Myers KR; Liu G; Feng Y; Zheng JQ
  • hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation.
    Mol Biol Cell Volume: 27 Page(s): 518 - 534
    02/01/2016 Authors: Williams KR; McAninch DS; Stefanovic S; Xing L; Allen M; Li W; Feng Y; Mihailescu MR; Bassell GJ
  • Expression of Quaking RNA-Binding Protein in the Adult and Developing Mouse Retina.
    PLoS One Volume: 11 Page(s): e0156033
    01/01/2016 Authors: Suiko T; Kobayashi K; Aono K; Kawashima T; Inoue K; Ku L; Feng Y; Koike C
  • Oligodendroglial Development: New Roles for Chromatin Accessibility.
    Neuroscientist Volume: 21 Page(s): 579 - 588
    12/01/2015 Authors: Huang N; Niu J; Feng Y; Xiao L
  • The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats.
    Neuroscience Volume: 290 Page(s): 552 - 560
    04/02/2015 Authors: Tan X; Chen Y; Li J; Li X; Miao Z; Xin N; Zhu J; Ge W; Feng Y; Xu X
  • Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).
    J Biol Chem Volume: 290 Page(s): 3468 - 3487
    02/06/2015 Authors: Wigington CP; Jung J; Rye EA; Belauret SL; Philpot AM; Feng Y; Santangelo PJ; Corbett AH
  • Impairment of Oligodendroglia Maturation Leads to Aberrantly Increased Cortical Glutamate and Anxiety-Like Behaviors in Juvenile Mice.
    Front Cell Neurosci Volume: 9 Page(s): 467
    01/01/2015 Authors: Chen X; Zhang W; Li T; Guo Y; Tian Y; Wang F; Liu S; Shen H-Y; Feng Y; Xiao L
  • A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia.
    Nucleic Acids Res Volume: 42 Page(s): 7319 - 7329
    06/01/2014 Authors: Mandler MD; Ku L; Feng Y
  • Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.
    Genes Dev Volume: 28 Page(s): 1191 - 1203
    06/01/2014 Authors: Xu Y; Gao XD; Lee J-H; Huang H; Tan H; Ahn J; Reinke LM; Peter ME; Feng Y; Gius D
  • The Rpe65 rd12 allele exerts a semidominant negative effect on vision in mice.
    Invest Ophthalmol Vis Sci Volume: 55 Page(s): 2500 - 2515
    04/17/2014 Authors: Wright CB; Chrenek MA; Feng W; Getz SE; Duncan T; Pardue MT; Feng Y; Redmond TM; Boatright JH; Nickerson JM
  • Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming.
    Stem Cell Reports Volume: 2 Page(s): 253 - 261
    03/11/2014 Authors: Zhu G; Li Y; Zhu F; Wang T; Jin W; Mu W; Lin W; Tan W; Li W; Street RC
  • PIKE is essential for oligodendroglia development and CNS myelination.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 1993 - 1998
    02/04/2014 Authors: Chan CB; Liu X; Zhao L; Liu G; Lee CW; Feng Y; Ye K
  • Neuron enriched nuclear proteome isolated from human brain.
    J Proteome Res Volume: 12 Page(s): 3193 - 3206
    07/05/2013 Authors: Dammer EB; Duong DM; Diner I; Gearing M; Feng Y; Lah JJ; Levey AI; Seyfried NT
  • p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair.
    J Biol Chem Volume: 288 Page(s): 18047 - 18057
    06/21/2013 Authors: Bankston AN; Li W; Zhang H; Ku L; Liu G; Papa F; Zhao L; Bibb JA; Cambi F; Tiwari-Woodruff SK
  • Oligodendroglia and neurotrophic factors in neurodegeneration.
    Neurosci Bull Volume: 29 Page(s): 216 - 228
    04/01/2013 Authors: Bankston AN; Mandler MD; Feng Y
  • HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA.
    PLoS One Volume: 8 Page(s): e55718
    01/01/2013 Authors: Allen M; Bird C; Feng W; Liu G; Li W; Perrone-Bizzozero NI; Feng Y
  • Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
    J Proteome Res Volume: 11 Page(s): 2721 - 2738
    05/04/2012 Authors: Seyfried NT; Gozal YM; Donovan LE; Herskowitz JH; Dammer EB; Xia Q; Ku L; Chang J; Duong DM; Rees HD
  • The QKI-PLP pathway controls SIRT2 abundance in CNS myelin.
    Glia Volume: 60 Page(s): 69 - 82
    01/01/2012 Authors: Zhu H; Zhao L; Wang E; Dimova N; Liu G; Feng Y; Cambi F
  • MicroRNAs in neural cell development and brain diseases.
    Sci China Life Sci Volume: 54 Page(s): 1103 - 1112
    12/01/2011 Authors: Feng W; Feng Y
  • Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation.
    Glia Volume: 59 Page(s): 1754 - 1769
    11/01/2011 Authors: Tyler WA; Jain MR; Cifelli SE; Li Q; Ku L; Feng Y; Li H; Wood TL
  • MECHANISMS FOR MTOR REGULATION OF OLIGODENDROCYTE DIFFERENTIATION & MYELINATION/REMYELINATION
    Volume: 118 Page(s): 87 - 87
    08/01/2011 Authors: Wood TL; Tyler WA; Jain MR; Cifelli SE; Mahajan K; Li Q; Ku L; Feng Y; Li H
  • Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.
    Proc Natl Acad Sci U S A Volume: 108 Page(s): 12390 - 12395
    07/26/2011 Authors: Pak C; Garshasbi M; Kahrizi K; Gross C; Apponi LH; Noto JJ; Kelly SM; Leung SW; Tzschach A; Behjati F
  • Mutation of a Zinc Finger Polyadenosine RNA Binding Protein Causes Autosomal Recessive Intellectual Disability in Humans and Neuronal Dysfunction in a Drosophila Model: A Critical Role for Control of Poly(A) Tail Length.
    Volume: 22
    01/01/2011 Authors: Corbett AH; Pak C; Garshasbi M; Kahrizi K; Gross C; Apponi LH; Noto JJ; Kelly SM; Leung SW; Feng Y
  • Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein.
    Proc Natl Acad Sci U S A Volume: 107 Page(s): 19061 - 19066
    11/02/2010 Authors: Zhao L; Mandler MD; Yi H; Feng Y
  • RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory.
    Proc Natl Acad Sci U S A Volume: 107 Page(s): 16994 - 16998
    09/28/2010 Authors: Lee SE; Simons SB; Heldt SA; Zhao M; Schroeder JP; Vellano CP; Cowan DP; Ramineni S; Yates CK; Feng Y
  • Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF).
    Proc Natl Acad Sci U S A Volume: 107 Page(s): 15945 - 15950
    09/07/2010 Authors: Lau AG; Irier HA; Gu J; Tian D; Ku L; Liu G; Xia M; Fritsch B; Zheng JQ; Dingledine R
  • Direct determination of molecular haplotypes by chromosome microdissection.
    Nat Methods Volume: 7 Page(s): 299 - 301
    04/01/2010 Authors: Ma L; Xiao Y; Huang H; Wang Q; Rao W; Feng Y; Zhang K; Song Q
  • The star family member QKI and cell signaling.
    Adv Exp Med Biol Volume: 693 Page(s): 25 - 36
    01/01/2010 Authors: Feng Y; Bankston A
  • Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells.
    Mol Endocrinol Volume: 24 Page(s): 148 - 160
    01/01/2010 Authors: Sidell N; Feng Y; Hao L; Wu J; Yu J; Kane MA; Napoli JL; Taylor RN
  • RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer.
    Gastroenterology Volume: 138 Page(s): 231-40.e1-5
    01/01/2010 Authors: Yang G; Fu H; Zhang J; Lu X; Yu F; Jin L; Bai L; Huang B; Shen L; Feng Y
  • BIOL 80 - Analysis of the microRNA let-7b interactions with microtubule associated protein 1B mRNA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 238 Page(s): 845 - 845
    08/16/2009 Authors: Blice-Baum AC; Feng Y; Mihailescu MR
  • Regulation of XIAP translation and induction by MDM2 following irradiation.
    Cancer Cell Volume: 15 Page(s): 363 - 375
    05/05/2009 Authors: Gu L; Zhu N; Zhang H; Durden DL; Feng Y; Zhou M
  • Translational regulation of GluR2 mRNAs in rat hippocampus by alternative 3' untranslated regions.
    J Neurochem Volume: 109 Page(s): 584 - 594
    04/01/2009 Authors: Irier HA; Shaw R; Lau A; Feng Y; Dingledine R
  • Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling.
    J Invest Dermatol Volume: 129 Page(s): 723 - 729
    03/01/2009 Authors: Gira AK; Kowalczyk AP; Feng Y; Swerlick RA
  • DIRECT QUANTIFICATION OF MYELIN CHANGES IN THE VERTEBRATE NERVOUS SYSTEM
    Volume: 108 Page(s): 66 - 66
    03/01/2009 Authors: Wang YM; Wu CY; Caprariello AV; Somoza E; Wang C; Zhu W; Feng Y; Miller RH
  • Molecular probes for imaging myelinated white matter in CNS.
    J Med Chem Volume: 51 Page(s): 6682 - 6688
    11/13/2008 Authors: Wu C; Wei J; Tian D; Feng Y; Miller RH; Wang Y
  • Essential function, sophisticated regulation and pathological impact of the selective RNA-binding protein QKI in CNS myelin development.
    Future Neurol Volume: 3 Page(s): 655 - 668
    11/01/2008 Authors: Bockbrader K; Feng Y
  • Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction.
    Neurochem Res Volume: 33 Page(s): 1940 - 1949
    10/01/2008 Authors: Feng Y
  • Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons.
    Cell Volume: 134 Page(s): 175 - 187
    07/11/2008 Authors: An JJ; Gharami K; Liao G-Y; Woo NH; Lau AG; Vanevski F; Torre ER; Jones KR; Feng Y; Lu B
  • Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
    Nat Cell Biol Volume: 10 Page(s): 698 - 706
    06/01/2008 Authors: Tang X; Jang S-W; Okada M; Chan C-B; Feng Y; Liu Y; Luo S-W; Hong Y; Rama N; Xiong W-C
  • Essential function of the selective RNA-binding protein QKI in myelin development
    Volume: 104 Page(s): 9 - 9
    03/01/2008 Authors: Feng Y; Zhao L; Tian D; Lin X; Osterhout DJ
  • Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes.
    Mol Biol Cell Volume: 19 Page(s): 105 - 114
    01/01/2008 Authors: Wang H; Dictenberg JB; Ku L; Li W; Bassell GJ; Feng Y
  • Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome.
    Neuron Volume: 55 Page(s): 556 - 564
    08/16/2007 Authors: Jin P; Duan R; Qurashi A; Qin Y; Tian D; Rosser TC; Liu H; Feng Y; Warren ST
  • The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation.
    J Biol Chem Volume: 282 Page(s): 23553 - 23560
    08/10/2007 Authors: Chen Y; Tian D; Ku L; Osterhout DJ; Feng Y
  • Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.
    Cell Death Differ Volume: 14 Page(s): 368 - 377
    02/01/2007 Authors: Tang X; Feng Y; Ye K
  • Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.
    J Neurosci Volume: 26 Page(s): 11278 - 11286
    11/01/2006 Authors: Zhao L; Tian D; Xia M; Macklin WB; Feng Y
  • QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development.
    Mol Biol Cell Volume: 17 Page(s): 4179 - 4186
    10/01/2006 Authors: Zhao L; Ku L; Chen Y; Xia M; LoPresti P; Feng Y
  • Microtubule stability and MAP1B upregulation control neuritogenesis in CAD cells.
    Acta Pharmacol Sin Volume: 27 Page(s): 1119 - 1126
    09/01/2006 Authors: Li W; Xia J-T; Feng Y
  • A novel fluorescent probe that is brain permeable and selectively binds to myelin.
    J Histochem Cytochem Volume: 54 Page(s): 997 - 1004
    09/01/2006 Authors: Wu C; Tian D; Feng Y; Polak P; Wei J; Sharp A; Stankoff B; Lubetzki C; Zalc B; Mufson EJ
  • Altered RNA editing in mice lacking ADAR2 autoregulation.
    Mol Cell Biol Volume: 26 Page(s): 480 - 488
    01/01/2006 Authors: Feng Y; Sansam CL; Singh M; Emeson RB
  • Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway.
    Proc Natl Acad Sci U S A Volume: 102 Page(s): 8549 - 8554
    06/14/2005 Authors: Soukoulis V; Reddy S; Pooley RD; Feng Y; Walsh CA; Bader DM
  • FRMP regulates MAP1B-based cytoskeletal dynamics in growth cone development
    Volume: 94 Page(s): 93 - 93
    06/01/2005 Authors: Lee JA; Lau A; Ku L; Feng Y
  • QuakingI promotes oligodendrocyte differentiation after cell cycle exit
    Volume: 94 Page(s): 109 - 109
    06/01/2005 Authors: Chen Y; Feng Y
  • Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation.
    J Biol Chem Volume: 280 Page(s): 389 - 395
    01/07/2005 Authors: Lu Z; Ku L; Chen Y; Feng Y
  • Fragile X protein functions with lgl and the par complex in flies and mice.
    Dev Cell Volume: 8 Page(s): 43 - 52
    01/01/2005 Authors: Zarnescu DC; Jin P; Betschinger J; Nakamoto M; Wang Y; Dockendorff TC; Feng Y; Jongens TA; Sisson JC; Knoblich JA
  • The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.
    Proc Natl Acad Sci U S A Volume: 101 Page(s): 15201 - 15206
    10/19/2004 Authors: Lu R; Wang H; Liang Z; Ku L; O'donnell WT; Li W; Warren ST; Feng Y
  • OKI mediates developmental signals to control CNS myelinogenesis via regulating mRNA metabolism
    Volume: 90 Page(s): 84 - 84
    08/01/2004 Authors: Feng Y; Lu Z; Zhang Y
  • QKI mediates developmental signals to control CNS myelinogenesis via regulating mRNA metabolism
    Volume: 10
    02/01/2004 Authors: Feng Y; Lu Z; Ku L
  • Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors.
    Hum Mol Genet Volume: 13 Page(s): 79 - 89
    01/01/2004 Authors: Wang H; Ku L; Osterhout DJ; Li W; Ahmadian A; Liang Z; Feng Y
  • Abnormal expression of MAP1B in fmr1 ko neurons during early neuritogenesis.
    Volume: 73 Page(s): 323 - 323
    11/01/2003 Authors: Lu RR; Li W; Ku L; Wang H; Feng Y
  • Differential reduction of qkl isoforms in human glioma cell lines.
    Volume: 73 Page(s): 229 - 229
    11/01/2003 Authors: Ku L; Feng Y
  • The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system.
    Nucleic Acids Res Volume: 31 Page(s): 4616 - 4624
    08/01/2003 Authors: Lu Z; Zhang Y; Ku L; Wang H; Ahmadian A; Feng Y
  • Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism.
    EMBO J Volume: 22 Page(s): 1801 - 1810
    04/15/2003 Authors: Zhang Y; Lu Z; Ku L; Chen Y; Wang H; Feng Y
  • The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.
    J Am Soc Nephrol Volume: 13 Page(s): 2823 - 2830
    12/01/2002 Authors: Yun CC; Palmada M; Embark HM; Fedorenko O; Feng Y; Henke G; Setiawan I; Boehmer C; Weinman EJ; Sandrasagra S
  • Fragile X mental retardation: misregulation of protein synthesis in the developing brain?
    Microsc Res Tech Volume: 57 Page(s): 145 - 147
    05/01/2002 Authors: Feng Y
  • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.
    Cell Volume: 107 Page(s): 477 - 487
    11/16/2001 Authors: Brown V; Jin P; Ceman S; Darnell JC; O'Donnell WT; Tenenbaum SA; Jin X; Feng Y; Wilkinson KD; Keene JD
  • The fragile X mental retardation protein inhibits translation via interacting with mRNA.
    Nucleic Acids Res Volume: 29 Page(s): 2276 - 2283
    06/01/2001 Authors: Li Z; Zhang Y; Ku L; Wilkinson KD; Warren ST; Feng Y
  • Distinct molecular mechanisms lead to diminished myelin basic protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase in qk(v) dysmyelination.
    J Neurochem Volume: 77 Page(s): 165 - 172
    04/01/2001 Authors: Zhang Y; Feng Y
  • Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene.
    Genetics Volume: 157 Page(s): 699 - 716
    02/01/2001 Authors: Keplinger BL; Guo X; Quine J; Feng Y; Cavener DR
  • Identification of polyribosomes-associated mRNAs regulated by fragile X mental retardation protein (FMRP) using oligonucleotide microarrays.
    AMERICAN JOURNAL OF HUMAN GENETICS Volume: 67 Page(s): 18 - 18
    10/01/2000 Authors: Jin P; Feng Y; Brown V; Warren ST
  • Destabilization and mislocalization of myelin basic protein mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins.
    J Neurosci Volume: 20 Page(s): 4944 - 4953
    07/01/2000 Authors: Li Z; Zhang Y; Li D; Feng Y
  • Destabilization and mislocalization of MBP mRNAs in quaking dysmyelination.
    FASEB JOURNAL Volume: 14 Page(s): A1409 - A1409
    05/11/2000 Authors: Zhang YY; Li ZZ; Feng Y
  • Estrogen-inducible, sex-specific expression of brain-derived neurotrophic factor mRNA in a forebrain song control nucleus of the juvenile zebra finch.
    Proc Natl Acad Sci U S A Volume: 96 Page(s): 8241 - 8246
    07/06/1999 Authors: Dittrich F; Feng Y; Metzdorf R; Gahr M
  • Cloning and characterization of RLPK, a novel RSK-related protein kinase.
    J Biol Chem Volume: 274 Page(s): 1026 - 1032
    01/08/1999 Authors: New L; Zhao M; Li Y; Bassett WW; Feng Y; Ludwig S; Padova FD; Gram H; Han J
  • Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein.
    J Biol Chem Volume: 273 Page(s): 15521 - 15527
    06/19/1998 Authors: Brown V; Small K; Lakkis L; Feng Y; Gunter C; Wilkinson KD; Warren ST
  • FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association.
    Mol Cell Volume: 1 Page(s): 109 - 118
    12/01/1997 Authors: Feng Y; Absher D; Eberhart DE; Brown V; Malter HE; Warren ST
  • FMRP associates with polyribosomes as an mRNP and the I304N mutation causing severe fragile X syndrome abolishes this association.
    AMERICAN JOURNAL OF HUMAN GENETICS Volume: 61 Page(s): A170 - A170
    10/01/1997 Authors: Feng Y; Absher D; Brown V; Eberhart DE; Malter HE; Warren ST
  • Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes.
    J Neurosci Volume: 17 Page(s): 1539 - 1547
    03/01/1997 Authors: Feng Y; Gutekunst CA; Eberhart DE; Yi H; Warren ST; Hersch SM
  • A fragile X male with a broad smear on Southern blot analysis representing 100-500 CGG repeats and no methylation at the EagI site of the FMR-1 gene.
    Am J Med Genet Volume: 64 Page(s): 278 - 282
    08/09/1996 Authors: Lachiewicz AM; Spiridigliozzi GA; McConkie-Rosell A; Burgess D; Feng Y; Warren ST; Tarleton J
  • The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.
    Hum Mol Genet Volume: 5 Page(s): 1083 - 1091
    08/01/1996 Authors: Eberhart DE; Malter HE; Feng Y; Warren ST
  • THE PROTEIN ABSENT IN FRAGILE-X SYNDROME (FMRP) IS A RIBOSOME-ASSOCIATED PROTEIN
    AMERICAN JOURNAL OF HUMAN GENETICS Volume: 57 Page(s): 40 - 40
    10/01/1995 Authors: FENG Y; EBERHART DE; WARREN ST
  • IDENTIFICATION OF A CYTOPLASMIC ANCHOR DOMAIN RESPONSIBLE FOR THE SUBCELLULAR-LOCALIZATION OF THE FRAGILE-X MENTAL-RETARDATION PROTEIN, FMRP
    AMERICAN JOURNAL OF HUMAN GENETICS Volume: 57 Page(s): 196 - 196
    10/01/1995 Authors: EBERHART DE; FENG Y; WARREN ST
  • Translational suppression by trinucleotide repeat expansion at FMR1.
    Science Volume: 268 Page(s): 731 - 734
    05/05/1995 Authors: Feng Y; Zhang F; Lokey LK; Chastain JL; Lakkis L; Eberhart D; Warren ST
  • Quantitative comparison of FMR1 gene expression in normal and premutation alleles.
    Am J Hum Genet Volume: 56 Page(s): 106 - 113
    01/01/1995 Authors: Feng Y; Lakkis L; Devys D; Warren ST
  • FMR-1 TRANSCRIPTIONAL STUDIES DEMONSTRATE NO DIFFERENCE BETWEEN NORMAL AND PREMUTATION ALLELES
    AMERICAN JOURNAL OF HUMAN GENETICS Volume: 53 Page(s): 681 - 681
    09/01/1993 Authors: FENG Y; WARREN ST
  • Evolution of the expression of the Gld gene in the reproductive tract of Drosophila.
    Mol Biol Evol Volume: 9 Page(s): 1029 - 1049
    11/01/1992 Authors: Schiff NM; Feng Y; Quine JA; Krasney PA; Cavener DR
  • Organ-specific patterns of gene expression in the reproductive tract of Drosophila are regulated by the sex-determination genes.
    Dev Biol Volume: 146 Page(s): 451 - 460
    08/01/1991 Authors: Feng Y; Schiff NM; Cavener DR
  • Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon.
    Mol Cell Biol Volume: 11 Page(s): 2149 - 2153
    04/01/1991 Authors: Feng Y; Gunter LE; Organ EL; Cavener DR
  • The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes.
    Nucleic Acids Res Volume: 16 Page(s): 3375 - 3390
    04/25/1988 Authors: Cavener D; Feng Y; Foster B; Krasney P; Murtha M; Schonbaum C; Xiao X
  • Effect of protein synthesis inhibition on gene expression during early development of Dictyostelium discoideum.
    Mol Cell Biol Volume: 8 Page(s): 10 - 16
    01/01/1988 Authors: Singleton CK; Manning SS; Feng Y
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