Yue Feng PhD
- Department of Pharmacology & Chemical Biology
Professor
- (404) 727-0351
- yfeng@emory.edu
-
Emory University School of Medicine
Pharmacology
1510 Clifton Rd, Room 5025
Overview
We are interested in how RNA-binding proteins and non-coding RNAs govern normal brain development and function, and how posttranscriptional dysregulation at the steps of mRNA biogenesis, stability, and translation may lead to malfunction of neurons and glia in mental and neurological diseases. Taking a multidisciplinary strategy and a combination of molecular, cellular, genetics and pharmacological approaches, our current research focuses on the following directions:
Regulation and function of the human neuronal and glial non-coding transcriptome in neurological and psychiatric diseases
Molecular mechanisms underlying myelination ad repair
Translational control in neuronal development, synaptic plasticity and brain disorders
Academic Appointment
- Professor with tenure, Department of Pharmacology, Emory University
Education
Degrees
- PhD from Vanderbilt University
- MD from Beijing Medical University
Research
Focus
- To elucidate how selective RNA-binding proteins and microRNAs control mRNA homeostasis and translation to govern normal function and development of the central nervous system, and how dysregulation at these posttranscriptional steps leads to myelin disorders and mental impairment.
Publications
-
Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.
Genome Med Volume: 16 Page(s): 129
11/11/2024 Authors: Wang F; Li Y; Shen H; Martinez-Feduchi P; Ji X; Teng P; Krishnakumar S; Hu J; Chen L; Feng Y -
Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration.
J Biol Chem Volume: 300 Page(s): 107595
08/01/2024 Authors: Zakutansky PM; Ku L; Zhang G; Shi L; Li Y; Yao B; Bassell GJ; Read RD; Feng Y -
The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
Brain Behav Immun Volume: 112 Page(s): 175 - 187
08/01/2023 Authors: Teng P; Li Y; Ku L; Wang F; Goldsmith DR; Wen Z; Yao B; Feng Y -
The Long Non-Coding RNA GOMAFU in Schizophrenia: Function, Disease Risk, and Beyond.
Cells Volume: 11
06/17/2022 Authors: Zakutansky PM; Feng Y -
Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation.
Genome Biol Volume: 23 Page(s): 48
02/07/2022 Authors: Li Y; Wang F; Teng P; Ku L; Chen L; Feng Y; Yao B -
Multifaceted Regulation of MicroRNA Biogenesis: Essential Roles and Functional Integration in Neuronal and Glial Development.
Int J Mol Sci Volume: 22
06/23/2021 Authors: Suster I; Feng Y -
Novel roles of an intragenic G-quadruplex in controlling microRNA expression and cardiac function.
Nucleic Acids Res Volume: 49 Page(s): 2522 - 2536
03/18/2021 Authors: Zhu M; Gao J; Lin X-J; Gong Y-Y; Qi Y-C; Ma Y-L; Song Y-X; Tan W; Li F-Y; Ye M -
Carbamazepine Restores Neuronal Signaling, Protein Synthesis, and Cognitive Function in a Mouse Model of Fragile X Syndrome.
Int J Mol Sci Volume: 21
12/07/2020 Authors: Ding Q; Zhang F; Feng Y; Wang H -
Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model.
Commun Biol Volume: 3 Page(s): 127
03/16/2020 Authors: Ding Q; Sethna F; Wu X-T; Miao Z; Chen P; Zhang Y; Xiao H; Feng W; Feng Y; Li X -
Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca2+ Entry and Release.
eNeuro Volume: 7
01/01/2020 Authors: Rui Y; Pollitt SL; Myers KR; Feng Y; Zheng JQ