Publications

• Suppression of LKB1-mutant lung adenocarcinoma by natural killer cells from females.
  J Natl Cancer Inst
  06/13/2025 Authors: Fan Y; Jin R; Monterroza L; Liu X; Huang C; Marra A; Mo X; Fu H; Gilbert-Ross M; Marcus AI
• Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer.
  Nat Commun Volume: 16 Page(s): 2324
  03/08/2025 Authors: Shu C; Li J; Rui J; Fan D; Niu Q; Bai R; Cicka D; Doyle S; Wahafu A; Zheng X
• Decoding the functional impact of the cancer genome through protein-protein interactions.
  Nat Rev Cancer Volume: 25 Page(s): 189 - 208
  03/01/2025 Authors: Fu H; Mo X; Ivanov AA
• Gain-of-function variants in SMAD4 compromise respiratory epithelial function.
  J Allergy Clin Immunol Volume: 155 Page(s): 107 - 119.e2
  01/01/2025 Authors: Lindsay ME; Scimone ER; Lawton J; Richa R; Yonker LM; Di YP; Buch K; Ouyang W; Mo X; Lin AE
• A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting the SMAD4-SMAD3-DNA complex.
  J Mol Cell Biol Volume: 15
  04/10/2024 Authors: Ouyang W; Li Q; Niu Q; Qui M; Fu H; Du Y; Mo X
• TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS.
  J Mol Cell Biol Volume: 15
  08/03/2023 Authors: Cicka D; Niu Q; Qui M; Qian K; Miller E; Fan D; Mo X; Ivanov AA; Sarafianos SG; Du Y
• A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting SMAD4-SMAD3-DNA complex.
  bioRxiv
  07/15/2023 Authors: Ouyang W; Niu Q; Qui M; Fu H; Du Y; Mo X
• Ligand dependent interaction between PC-TP and PPAR mitigates diet-induced hepatic steatosis in male mice.
  Nat Commun Volume: 14 Page(s): 2748
  05/12/2023 Authors: Druzak SA; Tardelli M; Mays SG; El Bejjani M; Mo X; Maner-Smith KM; Bowen T; Cato ML; Tillman MC; Sugiyama A
• Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells.
  Acta Pharmacol Sin Volume: 43 Page(s): 2419 - 2428
  09/01/2022 Authors: Shu C; Zheng X; Wuhafu A; Cicka D; Doyle S; Niu Q; Fan D; Qian K; Ivanov AA; Du Y
• Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
  Cell Volume: 185 Page(s): 1974 - 1985.e12
  05/26/2022 Authors: Mo X; Niu Q; Ivanov AA; Tsang YH; Tang C; Shu C; Li Q; Qian K; Wahafu A; Doyle SP
• A time-resolved fluorescence resonance energy transfer screening assay for discovery of protein-protein interaction modulators.
  STAR Protoc Volume: 2 Page(s): 100804
  09/17/2021 Authors: Tang C; Niu Q; Cicka D; Du Y; Mo X; Fu H
• Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF- signaling.
  Cell Chem Biol Volume: 28 Page(s): 636 - 647.e5
  05/20/2021 Authors: Tang C; Mo X; Niu Q; Wahafu A; Yang X; Qui M; Ivanov AA; Du Y; Fu H
• An expanded universe of cancer targets.
  Cell Volume: 184 Page(s): 1142 - 1155
  03/04/2021 Authors: Hahn WC; Bader JS; Braun TP; Califano A; Clemons PA; Druker BJ; Ewald AJ; Fu H; Jagu S; Kemp CJ
• High Throughput Screening Methods for PPI Inhibitor Discovery
  Volume: 78 Page(s): 49 - 86
  01/01/2021 Authors: Doyle SP; Mo X; Qian K; Cicka DN; Niu Q; Fu H
• Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening.
  J Mol Cell Biol Volume: 12 Page(s): 630 - 643
  08/01/2020 Authors: Du Y; Li X; Niu Q; Mo X; Qui M; Ma T; Kuo CJ; Fu H
• BRAF-V600E DEGRADATION AS A THERAPEUTIC STRATEGY IN BRAF-V600E MUTANT GLIOMAS
  Volume: 21 Page(s): 117 - 117
  04/01/2019 Authors: Zhao G; Muldoon D; Mo X; Tang C; Fu H; Gustafson WC; Weiss WA; Nicolaides T
• HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.
  Cell Chem Biol Volume: 26 Page(s): 331 - 339.e3
  03/21/2019 Authors: Mo X; Tang C; Niu Q; Ma T; Du Y; Fu H
• Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.
  J Mol Cell Biol Volume: 10 Page(s): 549 - 558
  12/01/2018 Authors: Rusnak L; Tang C; Qi Q; Mo X; Fu H
• In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.
  Nat Commun Volume: 9 Page(s): 2732
  07/16/2018 Authors: Grzeskowiak CL; Kundu ST; Mo X; Ivanov AA; Zagorodna O; Lu H; Chapple RH; Tsang YH; Moreno D; Mosqueda M
• The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target discovery.
  Bioinformatics Volume: 34 Page(s): 1183 - 1191
  04/01/2018 Authors: Ivanov AA; Revennaugh B; Rusnak L; Gonzalez-Pecchi V; Mo X; Johns MA; Du Y; Cooper LAD; Moreno CS; Khuri FR
• Dual gene activation and knockout screen reveals directional dependencies in genetic networks.
  Nat Biotechnol Volume: 36 Page(s): 170 - 178
  02/01/2018 Authors: Boettcher M; Tian R; Blau JA; Markegard E; Wagner RT; Wu D; Mo X; Biton A; Zaitlen N; Fu H
• OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.
  Oncogene Volume: 36 Page(s): 5852 - 5860
  10/19/2017 Authors: Ivanov AA; Gonzalez-Pecchi V; Khuri LF; Niu Q; Wang Y; Xu Y; Bai Y; Mo X; Prochownik EV; Johns MA
• AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay.
  Mol Pharmacol Volume: 91 Page(s): 339 - 347
  04/01/2017 Authors: Mo X; Qi Q; Ivanov AA; Niu Q; Luo Y; Havel J; Goetze R; Bell S; Moreno CS; Cooper LAD
• The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
  Nat Commun Volume: 8 Page(s): 14356
  02/16/2017 Authors: Li Z; Ivanov AA; Su R; Gonzalez-Pecchi V; Qi Q; Liu S; Webber P; McMillan E; Rusnak L; Pham C
• Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform.
  J Mol Cell Biol Volume: 8 Page(s): 271 - 281
  06/01/2016 Authors: Mo X-L; Luo Y; Ivanov AA; Su R; Havel JJ; Li Z; Khuri FR; Du Y; Fu H
• BRET: NanoLuc-Based Bioluminescence Resonance Energy Transfer Platform to Monitor Protein-Protein Interactions in Live Cells.
  Methods Mol Biol Volume: 1439 Page(s): 263 - 271
  01/01/2016 Authors: Mo X-L; Fu H
• Targeting GPR119 for the potential treatment of type 2 diabetes mellitus.
  Volume: 121 Page(s): 95 - 131
  01/01/2014 Authors: Mo X-L; Yang Z; Tao Y-X
• Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation.
  Int J Oncol Volume: 41 Page(s): 1373 - 1380
  10/01/2012 Authors: Hafiz S; Dennis JC; Schwartz D; Judd R; Tao Y-X; Khazal K; Akingbemi B; Mo X-L; Abdel-Mageed AB; Morrison E
• Polymer mixtures with enhanced compatibility and extremely low viscosity used as DNA separation media.
  Electrophoresis Volume: 31 Page(s): 520 - 527
  01/01/2010 Authors: Ke F; Mo X; Yang R; Wang Y; Liang D