Xu Liu
Overview
Xu received a B.S. in food science and engineering from Shandong Normal University in 2005 and M.S. in biochemistry from Beijing Normal University in China in 2008. He finished his PhD studies centered on PDZ domain-mediated protein/ligand interactions in University of Iowa in 2014. He then performed a short-term postdoctoral research in structure and inhibition of a histone demethylase family in Cheng lab in Emory University before he joined Ortlund lab in 2016. Here he focuses on investigating the structure-dynamics-function relationship of glucocorticoid receptor and an acyltransferase called tafazzin.
Academic Appointment
- Assistant Professor, Biochemistry, Emory University School of Medicine
Research
Publications
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Activity and phosphatidylcholine transfer protein interactions of skeletal muscle thioesterase Them2 enable hepatic steatosis and insulin resistance.
J Biol Chem Volume: 300 Page(s): 107855
11/01/2024 Authors: Xie Y; Liu X; Liu W; Carr LR; Lee LP; Imai N; Ortlund EA; Cohen DE -
Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate.
Nat Commun Volume: 15 Page(s): 5123
06/15/2024 Authors: Sastre DE; Sultana N; V A S Navarro M; Huliciak M; Du J; Cifuente JO; Flowers M; Liu X; Lollar P; Trastoy B -
Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.
Mol Cell Endocrinol Volume: 578 Page(s): 112068
12/01/2023 Authors: Proffitt MR; Liu X; Ortlund EA; Smith GT -
High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease.
Mol Metab Volume: 78 Page(s): 101832
12/01/2023 Authors: Krumm CS; Landzberg RS; Ramos-Espiritu L; Adura C; Liu X; Acuna M; Xie Y; Xu X; Tillman MC; Li Y -
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.
Nucleic Acids Res Volume: 51 Page(s): 7972 - 7987
08/25/2023 Authors: Head PE; Kapoor-Vazirani P; Nagaraju GP; Zhang H; Rath SK; Luong NC; Haji-Seyed-Javadi R; Sesay F; Wang S-Y; Duong DM -
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.
Nat Commun Volume: 13 Page(s): 6707
11/07/2022 Authors: Kapoor-Vazirani P; Rath SK; Liu X; Shu Z; Bowen NE; Chen Y; Haji-Seyed-Javadi R; Daddacha W; Minten EV; Danelia D -
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.
Cell Volume: 185 Page(s): 3603 - 3616.e13
09/15/2022 Authors: Frank F; Keen MM; Rao A; Bassit L; Liu X; Bowers HB; Patel AB; Cato ML; Sullivan JA; Greenleaf M -
A phospholipid mimetic targeting LRH-1 ameliorates colitis.
Cell Chem Biol Volume: 29 Page(s): 1174 - 1186.e7
07/21/2022 Authors: Mays SG; D'Agostino EH; Flynn AR; Huang X; Wang G; Liu X; Millings EJ; Okafor CD; Patel A; Cato ML -
Structural insights into glucocorticoid receptor function.
Biochem Soc Trans Volume: 49 Page(s): 2333 - 2343
11/01/2021 Authors: Frank F; Ortlund EA; Liu X -
Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element.
Nucleic Acids Res Volume: 49 Page(s): 8923 - 8933
09/07/2021 Authors: Liu X; Weikum ER; Tilo D; Vinson C; Ortlund EA