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Profile

Xin Hu PhD

  • RSPH Departments
    Assistant Professor
  • (404) 727-9979
  • xin.hu2@emory.edu
Head shot of Xin Hu

Academic Appointment

  • Assistant Professor, Medicine, Emory University

Education

Degrees

  • PhD from University of Iowa
  • BS from Tsinghua University

Research

Focus

  • Exposome, Environmental factors, Lung development, Metabolomics

    I have long-standing interest to study environmental contributions to lung disease. Current focus is to study adverse effects of prenatal exposure to contaminants in fetal development, in particular, respiratory airway development. I am experienced in applying molecular and systems biology methods including integrative omics to support a holistic research approach.

Publications

  • Discovery of phytochelatins in human urine: Evidence for function in selenium disposition and protection against cadmium.
    FASEB Bioadv Volume: 5 Page(s): 367 - 375
    09/01/2023 Authors: Jarrell ZR; Liu KH; Dennis KK; Hu X; Martin GS; Jones DP; Go Y-M
  • Study on the relationship between selenium and cadmium in diseased human lungs.
    Adv Redox Res Volume: 7
    04/01/2023 Authors: Smith MR; Hu X; Jarrell ZR; He X; Orr M; Fernandes J; Chandler JD; Walker DI; Esper A; Marts L
  • Antagonistic Interactions in Mitochondria ROS Signaling Responses to Manganese.
    Antioxidants (Basel) Volume: 12
    03/25/2023 Authors: Fernandes J; Uppal K; Liu KH; Hu X; Orr M; Tran V; Go Y-M; Jones DP
  • PISTACHIo (PreemptIon of diSrupTive behAvior in CHIldren): real-time monitoring of sleep and behavior of children 3-7 years old receiving parent-child interaction therapy augment with artificial intelligence - the study protocol, pilot study.
    Pilot Feasibility Stud Volume: 9 Page(s): 23
    02/09/2023 Authors: Saliba M; Drapeau N; Skime M; Hu X; Accardi CJ; Athreya AP; Kolacz J; Shekunov J; Jones DP; Croarkin PE
  • Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study.
    Environ Health Perspect Volume: 131 Page(s): 27005
    02/01/2023 Authors: Goodrich JA; Walker DI; He J; Lin X; Baumert BO; Hu X; Alderete TL; Chen Z; Valvi D; Fuentes ZC
  • Environmental Chemicals and their Association with Hyperparathyroidism.
    World J Surg Volume: 47 Page(s): 296 - 303
    02/01/2023 Authors: McMullin JL; Codner J; Patel SG; Sharma J; Hu X; Jones DP; Weber CJ; Saunders ND
  • Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host.
    mBio Volume: 13 Page(s): e0312522
    12/20/2022 Authors: Brothwell JA; Fortney KR; Gao H; Wilson LS; Andrews CF; Tran TM; Hu X; Batteiger TA; Barnes S; Liu Y
  • Plasma concentrations of lipophilic persistent organic pollutants and glucose homeostasis in youth populations.
    Environ Res Volume: 212 Page(s): 113296
    09/01/2022 Authors: Baumert BO; Goodrich JA; Hu X; Walker DI; Alderete TL; Chen Z; Valvi D; Rock S; Berhane K; Gilliland FD
  • Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection.
    Toxicol Sci Volume: 188 Page(s): 62 - 74
    06/28/2022 Authors: Jarrell ZR; Smith MR; Kim K-H; Lee Y; Hu X; He X; Orr M; Chen Y; Kang S-M; Jones DP
  • Evaluation of the Use of Saliva Metabolome as a Surrogate of Blood Metabolome in Assessing Internal Exposures to Traffic-Related Air Pollution.
    Environ Sci Technol Volume: 56 Page(s): 6525 - 6536
    05/17/2022 Authors: Li Z; Sarnat JA; Liu KH; Hood RB; Chang C-J; Hu X; Tran V; Greenwald R; Chang HH; Russell A
  • Low Dose Heavy Metal Exposure Disrupts Glutamine Catabolism in Airway Branching in Fetal Lung Development
    Volume: 205
    05/01/2022 Authors: Hu X; Liu KH; Ma J; Jarrell ZR; Orr ML; Tran V; Go Y; Marsit CJ; Jones DP; Wongtrakool C
  • Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.
    Nat Metab Volume: 3 Page(s): 1694 - 1705
    12/01/2021 Authors: Liu KH; Owens JA; Saeedi B; Cohen CE; Bellissimo MP; Naudin C; Darby T; Druzak S; Maner-Smith K; Orr M
  • An atlas of metallome and metabolome interactions and associations with incident diabetes in the Strong Heart Family Study.
    Environ Int Volume: 157 Page(s): 106810
    12/01/2021 Authors: Sanchez TR; Hu X; Zhao J; Tran V; Loiacono N; Go Y-M; Goessler W; Cole S; Umans J; Jones DP
  • Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival.
    Cancer Epidemiol Biomarkers Prev Volume: 30 Page(s): 1858 - 1866
    10/01/2021 Authors: Eldridge RC; Uppal K; Hayes DN; Smith MR; Hu X; Qin ZS; Beitler JJ; Miller AH; Wommack EC; Higgins KA
  • A scalable workflow to characterize the human exposome.
    Nat Commun Volume: 12 Page(s): 5575
    09/22/2021 Authors: Hu X; Walker DI; Liang Y; Smith MR; Orr ML; Juran BD; Ma C; Uppal K; Koval M; Martin GS
  • Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth.
    Environ Health Perspect Volume: 129 Page(s): 97002
    09/01/2021 Authors: Goodrich JA; Alderete TL; Baumert BO; Berhane K; Chen Z; Gilliland FD; Goran MI; Hu X; Jones DP; Margetaki K
  • Low Dose Heavy Metals Disrupt Metabolome and Inhibits Branching Morphogenesis in Fetal Lung Development
    Volume: 203
    05/01/2021 Authors: Hu X; Liu KH; Ma J; Orr ML; Tran V; Go Y; Jones DP; Marsit CJ; Wongtrakool C
  • Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults.
    Front Aging Neurosci Volume: 13 Page(s): 796067
    01/01/2021 Authors: Eldridge RC; Uppal K; Shokouhi M; Smith MR; Hu X; Qin ZS; Jones DP; Hajjar I
  • Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors.
    Surgery Volume: 169 Page(s): 102 - 108
    01/01/2021 Authors: Hu X; Saunders N; Safley S; Smith MR; Liang Y; Tran V; Sharma J; Jones DP; Weber CJ
  • 3,3'-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells.
    Environ Sci Technol Volume: 54 Page(s): 12345 - 12357
    10/06/2020 Authors: Zhang C-Y; Flor S; Ruiz P; Dhakal R; Hu X; Teesch LM; Ludewig G; Lehmler H-J
  • Plasma acylcarnitine levels increase with healthy aging.
    Aging (Albany NY) Volume: 12 Page(s): 13555 - 13570
    06/16/2020 Authors: Jarrell ZR; Smith MR; Hu X; Orr M; Liu KH; Quyyumi AA; Jones DP; Go Y-M
  • Omics Integration for Mitochondria Systems Biology.
    Antioxid Redox Signal Volume: 32 Page(s): 853 - 872
    04/20/2020 Authors: Hu X; Go Y-M; Jones DP
  • Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum.
    Reprod Toxicol Volume: 92 Page(s): 129 - 137
    03/01/2020 Authors: Hu X; Li S; Cirillo P; Krigbaum N; Tran V; Ishikawa T; La Merrill MA; Jones DP; Cohn B
  • Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's.
    Reprod Toxicol Volume: 92 Page(s): 57 - 65
    03/01/2020 Authors: Li S; Cirillo P; Hu X; Tran V; Krigbaum N; Yu S; Jones DP; Cohn B
  • Reprint of "Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum".
    Reprod Toxicol Volume: 92 Page(s): 120 - 128
    03/01/2020 Authors: Hu X; Li S; Cirillo PM; Krigbaum NY; Tran V; Jones DP; Cohn BA
  • Characterization of Nutritional and Environmental Metals after Cadmium Exposure in Mice
    Volume: 145 Page(s): S51 - S51
    12/01/2019 Authors: Smith MR; Orr M; Fernandes J; Neujahr D; Hu X; Jones D; Go Y-M
  • Metabolome-Wide Association Study of Vanadium Exposure Reveals Exacerbated Fatty Acid Oxidation in Human Plasma and Human Lung Fibroblasts
    Volume: 145 Page(s): S54 - S54
    12/01/2019 Authors: Smith MR; Fernandes J; Hu X; Liang D; Orr M; Sarnat J; Jones D; Go Y-M
  • Environmental Cadmium Enhances Lung Injury by Respiratory Syncytial Virus Infection.
    Am J Pathol Volume: 189 Page(s): 1513 - 1525
    08/01/2019 Authors: Hu X; Kim K-H; Lee Y; Fernandes J; Smith MR; Jung Y-J; Orr M; Kang S-M; Jones DP; Go Y-M
  • Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum.
    Reprod Toxicol Volume: 87 Page(s): 70 - 78
    08/01/2019 Authors: Hu X; Li S; Cirillo PM; Krigbaum NY; Tran V; Jones DP; Cohn BA
  • Cadmium at Human Dietary Levels Disturbed Homeostasis of Nutritional Metals in Lung (P24-055-19).
    Curr Dev Nutr Volume: 3
    06/01/2019 Authors: Go Y-M; Smith M; Fernandes J; Orr M; Hu X; Jones D
  • Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice.
    Environ Int Volume: 127 Page(s): 720 - 729
    06/01/2019 Authors: Chandler JD; Hu X; Ko E-J; Park S; Fernandes J; Lee Y-T; Orr ML; Hao L; Smith MR; Neujahr DC
  • Metabolomic Responses to Manganese Dose in SH-SY5Y Human Neuroblastoma Cells.
    Toxicol Sci Volume: 169 Page(s): 84 - 94
    05/01/2019 Authors: Fernandes J; Chandler JD; Liu KH; Uppal K; Hao L; Hu X; Go Y-M; Jones DP
  • Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung.
    Free Radic Biol Med Volume: 131 Page(s): 209 - 217
    02/01/2019 Authors: Hu X; Chandler JD; Park S; Liu K; Fernandes J; Orr M; Smith MR; Ma C; Kang S-M; Uppal K
  • Transcriptome Analysis Reveals Distinct Responses to Physiologic versus Toxic Manganese Exposure in Human Neuroblastoma Cells.
    Front Genet Volume: 10 Page(s): 676
    01/01/2019 Authors: Fernandes J; Chandler JD; Lili LN; Uppal K; Hu X; Hao L; Go Y-M; Jones DP
  • Environmental cadmium enhances respiratory syncytial virus infection-caused lung injury via mitochondrial metabolic disruption and oxidative stress
    Volume: 128 Page(s): S26 - S27
    11/20/2018 Authors: Go Y-M; Hu X; Kim K-H; Lee Y; Fernandes J; Smith MR; Jung Y-J; Orr M; Kang S-M; Jones D
  • Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung
    Volume: 128 Page(s): S86 - S86
    11/20/2018 Authors: Hu X; Chandler J; Park S; Liu KH; Fernandes J; Orr M; Smith MR; Ma C; Kang S-M; Uppal K
  • Selenium at the redox interface of the genome, metabolome and exposome.
    Free Radic Biol Med Volume: 127 Page(s): 215 - 227
    11/01/2018 Authors: Fernandes J; Hu X; Ryan Smith M; Go Y-M; Jones DP
  • Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung.
    Biochim Biophys Acta Gen Subj Volume: 1862 Page(s): 2417 - 2426
    11/01/2018 Authors: Hu X; Chandler JD; Fernandes J; Orr ML; Hao L; Uppal K; Neujahr DC; Jones DP; Go Y-M
  • Selenium Supplementation Alters Hepatic Energy and Fatty Acid Metabolism in Mice.
    J Nutr Volume: 148 Page(s): 675 - 684
    05/01/2018 Authors: Hu X; Chandler JD; Orr ML; Hao L; Liu K; Uppal K; Go Y-M; Jones DP
  • Mitochondrial network responses in oxidative physiology and disease.
    Free Radic Biol Med Volume: 116 Page(s): 31 - 40
    02/20/2018 Authors: Go Y-M; Fernandes J; Hu X; Uppal K; Jones DP
  • Integrative Omics-identified Potential Toxicity of Environmental and Nutritional Metals
    Volume: 112 Page(s): 164 - 164
    11/01/2017 Authors: Go Y-M; Hu X; Chandler J; Jones DP
  • Integrative omics-defined redox, metabolic and functional responses to environmental metal exposure
    Volume: 108 Page(s): S106 - S106
    07/01/2017 Authors: Go Y-M; Hu X; Chandler J; Fernandes J; Jones DP
  • Cadmium stimulates myofibroblast differentiation and mouse lung fibrosis.
    Toxicology Volume: 383 Page(s): 50 - 56
    05/15/2017 Authors: Hu X; Fernandes J; Jones DP; Go Y-M
  • From the Cover: Manganese Stimulates Mitochondrial H2O2 Production in SH-SY5Y Human Neuroblastoma Cells Over Physiologic as well as Toxicologic Range.
    Toxicol Sci Volume: 155 Page(s): 213 - 223
    01/01/2017 Authors: Fernandes J; Hao L; Bijli KM; Chandler JD; Orr M; Hu X; Jones DP; Go Y-M
  • Integration of Multi-Omics Data Reveal Dynamic Oxidative Stress Responses to Manganese in Human SH-SY5Y Neuroblastoma Cells
    Volume: 100 Page(s): S160 - S160
    11/01/2016 Authors: Fernandes J; Uppal K; Chandler JD; Lili LN; Hu X; Go Y-M; Jones DP
  • Low Dose Cadmium Stimulates Myofibroblast Differentiation and Lung Fibrosis by Activation of SMAD and Nuclear Thioredoxin-1
    Volume: 100 Page(s): S40 - S41
    11/01/2016 Authors: Hu X; Fernandes J; Jones DP; Go Y-M
  • Lung Cysteine/cystine Redox Potential Increase Is Associated with Worse Inflammation and Disrupted Metabolism during H1N1 Infection and Exposure to Dietary Levels of Cadmium
    Volume: 100 Page(s): S52 - S52
    11/01/2016 Authors: Chandler JD; Hu X; Ko E; Park S; Fernandes J; Orr ML; Lee Y-T; Jones DP; Kang S-M; Go Y-M
  • Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice.
    Am J Physiol Regul Integr Comp Physiol Volume: 311 Page(s): R906 - R916
    11/01/2016 Authors: Chandler JD; Hu X; Ko E-J; Park S; Lee Y-T; Orr M; Fernandes J; Uppal K; Kang S-M; Jones DP
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