William O'Neill MD
Overview
Dr. O'Neill has an active basic and translational research program and is also director of the ultrasonography program in the Renal Division. His NIH-sponsored research is in the area of vascular calcification, specifically on the role of endogenous pyrophosphate in the etiology of vascular calcification. Dr. O'Neill's clinical interest is in renal imaging and interventional nephrology. He directs the ultrasound program in the Renal Division, which he initiated in 1994, and directs numerous courses for nephrologists at Emory and at national and international meetings. He is past-president and founding member of the American Society of Diagnostic and Interventional Nephrology.
Current research focuses on the pathophysiology of vascular calcification in renal failure with particular emphasis on the role of endogenous calcification inhibitors such as pyrophosphate and matrix Gla protein. In addition, the role of vitamin D in vascular calcification is being investigated. Potential therapies based on the central role of pyrophosphate are being developed and tested, including pyrophosphate analogs and novel inhibitors of alkaline phosphatase. Studies are performed on animal models and on an in vitro vessel culture system developed in this laboratory.
Dr. O'Neill directs the ultrasonography service in the renal division. The service performs diagnostic studies of kidneys, renal transplants, and urinary bladders, as well as guidance for percutaneous renal biopsies. This program has been in operation since 1994 and currently over 1200 studies are performed per year. Dr. O'Neill has directed CME courses for outside nephrologists since 1997. Information on these courses can be found on the education page of the Renal Division. This clinical area has also been the focus of research relating to imaging in renal disease.
Academic Appointment
- Professor of Medicine, Emory University School of Medicine
- Associate Professor of Medicine, Emory University School of Medicine
- Assistant Professor of Physiology, Emory University School of Medicine
- Assistant Professor of Medicine, Emory University School of Medicine
Education
Degrees
- MD from Tufts University School of Medicine
- BS from Massachusetts Institute of Technology
Research
Publications
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Performance and Interpretation of Sonography in the Practice of Nephrology: Core Curriculum 2024.
Am J Kidney Dis Volume: 83 Page(s): 531 - 545
04/01/2024 Authors: Niyyar VD; Ross DW; O'Neill WC -
An Alternate Explanation.
N Engl J Med Volume: 389 Page(s): 1250 - 1251
09/28/2023 Authors: O'Neill WC -
Targeting Vascular Calcification in CKD: Time to Redraw the Map.
Kidney360 Volume: 4 Page(s): e838 - e840
06/01/2023 Authors: O'Neill WC -
Should vitamin K antagonists ever be used in ESRD?
Semin Dial Volume: 36 Page(s): 83 - 85
03/01/2023 Authors: O'Neill WC -
Metabolic alkalosis in hemodialysis patients.
Semin Dial Volume: 36 Page(s): 24 - 28
01/01/2023 Authors: Mudunuru SA; Navarrete J; O'Neill WC -
Point-of-Care Ultrasound Training during Nephrology Fellowship: A National Survey of Fellows and Program Directors.
Clin J Am Soc Nephrol Volume: 17 Page(s): 1487 - 1494
10/01/2022 Authors: Moore CA; Ross DW; Pivert KA; Lang VJ; Sozio SM; O'Neill WC -
Serum Protein-Induced Tubular Injury.
J Am Soc Nephrol Volume: 33 Page(s): 1627
08/01/2022 Authors: O'Neill WC -
SCU-Net: A deep learning method for segmentation and quantification of breast arterial calcifications on mammograms.
Med Phys Volume: 48 Page(s): 5851 - 5861
10/01/2021 Authors: Guo X; O'Neill WC; Vey B; Yang TC; Kim TJ; Ghassemi M; Pan I; Gichoya JW; Trivedi H; Banerjee I -
Vascular Calcification Slows But Does Not Regress After Kidney Transplantation.
Kidney Int Rep Volume: 5 Page(s): 2212 - 2217
12/01/2020 Authors: Alappan HR; Vasanth P; Manzoor S; O'Neill WC -
Cerebral blood flow regulation in end-stage kidney disease.
Am J Physiol Renal Physiol Volume: 319 Page(s): F782 - F791
11/01/2020 Authors: Sprick JD; Nocera JR; Hajjar I; O'Neill WC; Bailey J; Park J