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Profile

William O'Neill MD

  • Department of Medicine
    Professor
  • (404) 727-3922
  • woneill@emory.edu
Head shot of William O'Neill

Overview

Dr. O'Neill has an active basic and translational research program and is also director of the ultrasonography program in the Renal Division. His NIH-sponsored research is in the area of vascular calcification, specifically on the role of endogenous pyrophosphate in the etiology of vascular calcification. Dr. O'Neill's clinical interest is in renal imaging and interventional nephrology. He directs the ultrasound program in the Renal Division, which he initiated in 1994, and directs numerous courses for nephrologists at Emory and at national and international meetings. He is past-president and founding member of the American Society of Diagnostic and Interventional Nephrology.

Current research focuses on the pathophysiology of vascular calcification in renal failure with particular emphasis on the role of endogenous calcification inhibitors such as pyrophosphate and matrix Gla protein. In addition, the role of vitamin D in vascular calcification is being investigated. Potential therapies based on the central role of pyrophosphate are being developed and tested, including pyrophosphate analogs and novel inhibitors of alkaline phosphatase. Studies are performed on animal models and on an in vitro vessel culture system developed in this laboratory.

Dr. O'Neill directs the ultrasonography service in the renal division. The service performs diagnostic studies of kidneys, renal transplants, and urinary bladders, as well as guidance for percutaneous renal biopsies. This program has been in operation since 1994 and currently over 1200 studies are performed per year. Dr. O'Neill has directed CME courses for outside nephrologists since 1997. Information on these courses can be found on the education page of the Renal Division. This clinical area has also been the focus of research relating to imaging in renal disease.

Academic Appointment

  • Professor of Medicine, Emory University School of Medicine
  • Associate Professor of Medicine, Emory University School of Medicine
  • Assistant Professor of Physiology, Emory University School of Medicine
  • Assistant Professor of Medicine, Emory University School of Medicine

Education

Degrees

  • MD from Tufts University School of Medicine
  • BS from Massachusetts Institute of Technology

Research

Publications

  • Performance and Interpretation of Sonography in the Practice of Nephrology: Core Curriculum 2024.
    Am J Kidney Dis Volume: 83 Page(s): 531 - 545
    04/01/2024 Authors: Niyyar VD; Ross DW; O'Neill WC
  • An Alternate Explanation.
    N Engl J Med Volume: 389 Page(s): 1250 - 1251
    09/28/2023 Authors: O'Neill WC
  • Targeting Vascular Calcification in CKD: Time to Redraw the Map.
    Kidney360 Volume: 4 Page(s): e838 - e840
    06/01/2023 Authors: O'Neill WC
  • Should vitamin K antagonists ever be used in ESRD?
    Semin Dial Volume: 36 Page(s): 83 - 85
    03/01/2023 Authors: O'Neill WC
  • Metabolic alkalosis in hemodialysis patients.
    Semin Dial Volume: 36 Page(s): 24 - 28
    01/01/2023 Authors: Mudunuru SA; Navarrete J; O'Neill WC
  • Point-of-Care Ultrasound Training during Nephrology Fellowship: A National Survey of Fellows and Program Directors.
    Clin J Am Soc Nephrol Volume: 17 Page(s): 1487 - 1494
    10/01/2022 Authors: Moore CA; Ross DW; Pivert KA; Lang VJ; Sozio SM; O'Neill WC
  • Serum Protein-Induced Tubular Injury.
    J Am Soc Nephrol Volume: 33 Page(s): 1627
    08/01/2022 Authors: O'Neill WC
  • SCU-Net: A deep learning method for segmentation and quantification of breast arterial calcifications on mammograms.
    Med Phys Volume: 48 Page(s): 5851 - 5861
    10/01/2021 Authors: Guo X; O'Neill WC; Vey B; Yang TC; Kim TJ; Ghassemi M; Pan I; Gichoya JW; Trivedi H; Banerjee I
  • Vascular Calcification Slows But Does Not Regress After Kidney Transplantation.
    Kidney Int Rep Volume: 5 Page(s): 2212 - 2217
    12/01/2020 Authors: Alappan HR; Vasanth P; Manzoor S; O'Neill WC
  • Cerebral blood flow regulation in end-stage kidney disease.
    Am J Physiol Renal Physiol Volume: 319 Page(s): F782 - F791
    11/01/2020 Authors: Sprick JD; Nocera JR; Hajjar I; O'Neill WC; Bailey J; Park J
  • Point-of-Care Ultrasound for Native Kidney Biopsies.
    Kidney360 Volume: 1 Page(s): 527 - 529
    06/25/2020 Authors: Palacherla J; O'Neill WC
  • Warfarin Accelerates Medial Arterial Calcification in Humans.
    Arterioscler Thromb Vasc Biol Volume: 40 Page(s): 1413 - 1419
    05/01/2020 Authors: Alappan HR; Kaur G; Manzoor S; Navarrete J; O'Neill WC
  • Retooling Nephrology with Ultrasound.
    Clin J Am Soc Nephrol Volume: 14 Page(s): 771 - 773
    05/07/2019 Authors: O'Neill WC; Ross DW
  • Renal Hypertrophy in Liver Failure.
    Kidney Int Rep Volume: 3 Page(s): 1464 - 1467
    11/01/2018 Authors: Saad M; Ellis CL; O'Neill WC
  • Progression of Medial Arterial Calcification in CKD.
    Kidney Int Rep Volume: 3 Page(s): 1328 - 1335
    11/01/2018 Authors: Manzoor S; Ahmed S; Ali A; Han KH; Sechopoulos I; O'Neill A; Fei B; O'Neill WC
  • Questionable specificity of histologic findings incalcific uremic arteriolopathy.
    Kidney Int Volume: 94 Page(s): 390 - 395
    08/01/2018 Authors: Ellis CL; O'Neill WC
  • Pyrophosphate deficiency in vascular calcification.
    Kidney Int Volume: 93 Page(s): 1293 - 1297
    06/01/2018 Authors: Villa-Bellosta R; O'Neill WC
  • Point-of-care ultrasound in the practice ofnephrology.
    Kidney Int Volume: 93 Page(s): 1052 - 1059
    05/01/2018 Authors: Niyyar VD; O'Neill WC
  • Understanding the pathogenesis of vascular calcification:timing is everything.
    Kidney Int Volume: 92 Page(s): 1316 - 1318
    12/01/2017 Authors: O'Neill WC
  • Introduction to Imaging in Dialysis Patients.
    Semin Dial Volume: 30 Page(s): 289
    07/01/2017 Authors: O'Neill WC
  • Imaging for Vascular Calcification.
    Semin Dial Volume: 30 Page(s): 347 - 352
    07/01/2017 Authors: Raggi P; O'Neill WC
  • Diagnosis and Management of Acquired Cystic Kidney Disease and Renal Tumors in ESRD Patients.
    Semin Dial Volume: 30 Page(s): 373 - 379
    07/01/2017 Authors: Rahbari-Oskoui F; O'Neill WC
  • DEATH AND DIALYSIS RISK AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
    Volume: 69 Page(s): 1212 - 1212
    03/21/2017 Authors: Hansen JW; Foy A; Yadav P; Gilchrist I; Kozak M; Wang A; Wang DD; Eng M; Greenbaum A; O'Neill W
  • RENAL ENLARGEMENT IN END STAGE LIVER DISEASE
    Volume: 65 Page(s): 566 - 567
    02/01/2017 Authors: Saad M; O'Neill WC
  • Small Vessel and Soft Tissue Histology in End-Stage Renal Disease: Specificity of Diagnostic Criteria for Calciphylaxis
    Volume: 30 Page(s): 82A - 82A
    02/01/2017 Authors: Ellis C; O'Neill WC
  • Small Vessel and Soft Tissue Histology in End-Stage Renal Disease: Specificity of Diagnostic Criteria for Calciphylaxis
    Volume: 97 Page(s): 82A - 82A
    02/01/2017 Authors: Ellis C; O'Neill WC
  • Persistence of Vascular Calcification after Reversal of Uremia.
    Am J Pathol Volume: 187 Page(s): 332 - 338
    02/01/2017 Authors: Lomashvili KA; Manning KE; Weitzmann MN; Nelea V; McKee MD; O'Neill WC
  • Acute and 3-month effects of calcium carbonate on the calcification propensity of serum and regulators of vascular calcification: secondary analysis of a randomized controlled trial.
    Osteoporos Int Volume: 27 Page(s): 1209 - 1216
    03/01/2016 Authors: Bristow SM; Gamble GD; Pasch A; O'Neill WC; Stewart A; Horne AM; Reid IR
  • Increased Peripheral Arterial Calcification in Patients Receiving Warfarin.
    J Am Heart Assoc Volume: 5
    01/25/2016 Authors: Han KH; O'Neill WC
  • Targeting serum calcium in chronic kidney disease and end-stage renal disease: is normal too high?
    Kidney Int Volume: 89 Page(s): 40 - 45
    01/01/2016 Authors: O'Neill WC
  • The association of bone and osteoclasts with vascular calcification.
    Vasc Med Volume: 20 Page(s): 527 - 533
    12/01/2015 Authors: Han KH; Hennigar RA; O'Neill WC
  • A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease.
    Kidney Int Volume: 88 Page(s): 146 - 151
    07/01/2015 Authors: Bhutani H; Smith V; Rahbari-Oskoui F; Mittal A; Grantham JJ; Torres VE; Mrug M; Bae KT; Wu Z; Ge Y
  • Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.
    J Bone Miner Res Volume: 30 Page(s): 824 - 836
    05/01/2015 Authors: Sheen CR; Kuss P; Narisawa S; Yadav MC; Nigro J; Wang W; Chhea TN; Sergienko EA; Kapoor K; Jackson MR
  • Prevalence of nonatheromatous lesions in peripheral arterial disease.
    Arterioscler Thromb Vasc Biol Volume: 35 Page(s): 439 - 447
    02/01/2015 Authors: O'Neill WC; Han KH; Schneider TM; Hennigar RA
  • Increased vascular calcification in patients receiving warfarin.
    Arterioscler Thromb Vasc Biol Volume: 35 Page(s): 237 - 242
    01/01/2015 Authors: Tantisattamo E; Han KH; O'Neill WC
  • The clinical significance of medial arterial calcification in end-stage renal disease in women.
    Kidney Int Volume: 87 Page(s): 195 - 199
    01/01/2015 Authors: Abou-Hassan N; Tantisattamo E; D'Orsi ET; O'Neill WC
  • Renal resistive index: a case of mistaken identity.
    Hypertension Volume: 64 Page(s): 915 - 917
    11/01/2014 Authors: O'Neill WC
  • The author replies.
    Kidney Int Volume: 86 Page(s): 858
    10/01/2014 Authors: O'Neill WC
  • The role of inorganic pyrophosphate in aortic valve calcification.
    J Heart Valve Dis Volume: 23 Page(s): 387 - 394
    07/01/2014 Authors: Rathan S; Yoganathan AP; O'Neill CW
  • Vascular calcification is dependent on plasma levels of pyrophosphate.
    Kidney Int Volume: 85 Page(s): 1351 - 1356
    06/01/2014 Authors: Lomashvili KA; Narisawa S; Milln JL; O'Neill WC
  • Breast arterial calcification in chronic kidney disease: absence of smooth muscle apoptosis and osteogenic transdifferentiation.
    Kidney Int Volume: 85 Page(s): 668 - 676
    03/01/2014 Authors: O'Neill WC; Adams AL
  • Structure, not just function.
    Kidney Int Volume: 85 Page(s): 503 - 505
    03/01/2014 Authors: O'Neill WC
  • Renal relevant radiology: use of ultrasound in kidney disease and nephrology procedures.
    Clin J Am Soc Nephrol Volume: 9 Page(s): 373 - 381
    02/01/2014 Authors: O'Neill WC
  • Role of local versus systemic vitamin D receptors in vascular calcification.
    Arterioscler Thromb Vasc Biol Volume: 34 Page(s): 146 - 151
    01/01/2014 Authors: Lomashvili KA; Wang X; O'Neill WC
  • Sodium thiosulfate: mythical treatment for a mysterious disease?
    Clin J Am Soc Nephrol Volume: 8 Page(s): 1068 - 1069
    07/01/2013 Authors: O'Neill WC
  • The risk for medial arterial calcification in CKD.
    Clin J Am Soc Nephrol Volume: 7 Page(s): 275 - 279
    02/01/2012 Authors: Hassan NA; D'Orsi ET; D'Orsi CJ; O'Neill WC
  • The chemistry of thiosulfate and vascular calcification.
    Nephrol Dial Transplant Volume: 27 Page(s): 521 - 526
    02/01/2012 Authors: O'Neill WC; Hardcastle KI
  • Using a filtration technique to isolate platelet free plasma for assaying pyrophosphate.
    Clin Lab Volume: 58 Page(s): 1129 - 1134
    01/01/2012 Authors: Tolouian R; Connery SM; O'Neill WC; Gupta A
  • Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.
    J Biol Chem Volume: 286 Page(s): 28715 - 28722
    08/19/2011 Authors: Lomashvili KA; Wang X; Wallin R; O'Neill WC
  • Effect of medial calcification on vascular function in uremia.
    Am J Physiol Renal Physiol Volume: 301 Page(s): F78 - F83
    07/01/2011 Authors: Sutliff RL; Walp ER; El-Ali AM; Elkhatib S; Lomashvili KA; O'Neill WC
  • Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.
    Am J Physiol Heart Circ Physiol Volume: 301 Page(s): H61 - H68
    07/01/2011 Authors: Villa-Bellosta R; Wang X; Milln JL; Dubyak GR; O'Neill WC
  • Imaging for renovascular disease.
    Semin Nephrol Volume: 31 Page(s): 272 - 282
    05/01/2011 Authors: O'Neill WC; Bardelli M; Yevzlin AS
  • NOVEL USE OF A SERUM FRACTIONATION CENTRIFUGE TUBES IN MEASURING INORGANIC PYROPHOSPHATE IN DIALYSIS PATIENTS
    Volume: 57 Page(s): A95 - A95
    04/01/2011 Authors: Tolouian R; Connery SM; O'Neill WC; Gupta A
  • Treatment with pyrophosphate inhibits uremic vascular calcification.
    Kidney Int Volume: 79 Page(s): 512 - 517
    03/01/2011 Authors: O'Neill WC; Lomashvili KA; Malluche HH; Faugere M-C; Riser BL
  • THE USE OF SCREENING MAMMOGRAPHY TO DETERMINE THE RISK OF MEDIAL VASCULAR CALCIFICATION IN CHRONIC KIDNEY DISEASE
    Volume: 59 Page(s): 458 - 458
    02/01/2011 Authors: Hassan AN; O'Neill W
  • Breast arterial calcification: a marker of medial vascular calcification in chronic kidney disease.
    Clin J Am Soc Nephrol Volume: 6 Page(s): 377 - 382
    02/01/2011 Authors: Duhn V; D'Orsi ET; Johnson S; D'Orsi CJ; Adams AL; O'Neill WC
  • A daunting task but largely successful in developing meaningful guidelines.
    Semin Dial Volume: 24 Page(s): 24 - 27
    01/01/2011 Authors: O'Neill WC
  • Determinants and functional significance of renal parenchymal volume in adults.
    Clin J Am Soc Nephrol Volume: 6 Page(s): 70 - 76
    01/01/2011 Authors: Johnson S; Rishi R; Andone A; Khawandi W; Al-Said J; Gletsu-Miller N; Lin E; Baumgarten DA; O'Neill WC
  • Recent progress in the treatment of vascular calcification.
    Kidney Int Volume: 78 Page(s): 1232 - 1239
    12/01/2010 Authors: O'Neill WC; Lomashvili KA
  • Regulation of vascular smooth muscle cell calcification by extracellular pyrophosphate homeostasis: synergistic modulation by cyclic AMP and hyperphosphatemia.
    Am J Physiol Cell Physiol Volume: 298 Page(s): C702 - C713
    03/01/2010 Authors: Prosdocimo DA; Wyler SC; Romani AM; O'Neill WC; Dubyak GR
  • Plasma pyrophosphate and vascular calcification in chronic kidney disease.
    Nephrol Dial Transplant Volume: 25 Page(s): 187 - 191
    01/01/2010 Authors: O'Neill WC; Sigrist MK; McIntyre CW
  • Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
    J Med Chem Volume: 52 Page(s): 6919 - 6925
    11/12/2009 Authors: Dahl R; Sergienko EA; Su Y; Mostofi YS; Yang L; Simao AM; Narisawa S; Brown B; Mangravita-Novo A; Vicchiarelli M
  • Acute kidney injury in a patient with unilateral ureteral obstruction.
    Am J Kidney Dis Volume: 54 Page(s): 775 - 779
    10/01/2009 Authors: Gosmanova EO; Baumgarten DA; O'Neill WC
  • Mineral complexes and vascular calcification.
    Kidney Int Volume: 76 Page(s): 915
    10/01/2009 Authors: O'Neill WC
  • Application of ultrasound in nephrology practice.
    Adv Chronic Kidney Dis Volume: 16 Page(s): 396 - 404
    09/01/2009 Authors: Gosmanova EO; Wu S; O'Neill WC
  • Improving training in nephrology procedures: yes we can.
    Am J Kidney Dis Volume: 54 Page(s): 4 - 5
    07/01/2009 Authors: O'Neill WC
  • Response to 'On vascular calcification prevention with phosphonoformate and bisphosphonates'.
    Kidney Int Volume: 75 Page(s): 1356
    06/02/2009 Authors: Lomashvili KA; O'Neill WC
  • Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells.
    Am J Physiol Cell Physiol Volume: 296 Page(s): C828 - C839
    04/01/2009 Authors: Prosdocimo DA; Douglas DC; Romani AM; O'Neill WC; Dubyak GR
  • Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure.
    Kidney Int Volume: 75 Page(s): 617 - 625
    03/01/2009 Authors: Lomashvili KA; Monier-Faugere M-C; Wang X; Malluche HH; O'Neill WC
  • AIUM practice guideline for the performance of renal artery duplex sonography.
    J Ultrasound Med Volume: 28 Page(s): 120 - 124
    01/01/2009 Authors: American Institute of Ultrasound in Medicine; American College of Radiology
  • Treatment of vascular calcification.
    Kidney Int Volume: 74 Page(s): 1376 - 1378
    12/01/2008 Authors: O'Neill WC
  • Performance of procedures by nephrologists and nephrology fellows at U.S. nephrology training programs.
    Clin J Am Soc Nephrol Volume: 3 Page(s): 941 - 947
    07/01/2008 Authors: Berns JS; O'Neill WC
  • Matrix Gla protein inhibits vascular calcification independent of osteogenic pathways
    Volume: 28 Page(s): E148 - E148
    06/01/2008 Authors: Lomashvili K; Wallin R; O'Neill WC
  • Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification.
    Kidney Int Volume: 73 Page(s): 1024 - 1030
    05/01/2008 Authors: Lomashvili KA; Garg P; Narisawa S; Millan JL; O'Neill WC
  • Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.
    J Bone Miner Res Volume: 22 Page(s): 1700 - 1710
    11/01/2007 Authors: Narisawa S; Harmey D; Yadav MC; O'Neill WC; Hoylaerts MF; Milln JL
  • The fallacy of the calcium-phosphorus product.
    Kidney Int Volume: 72 Page(s): 792 - 796
    10/01/2007 Authors: O'Neill WC
  • Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone.
    Am J Physiol Heart Circ Physiol Volume: 292 Page(s): H2100 - H2105
    05/01/2007 Authors: Garg P; Martin CF; Elms SC; Gordon FJ; Wall SM; Garland CJ; Sutliff RL; O'Neill WC
  • Vascular calcification: not so crystal clear.
    Kidney Int Volume: 71 Page(s): 282 - 283
    02/01/2007 Authors: O'Neill WC
  • Pyrophosphate, alkaline phosphatase, and vascular calcification.
    Circ Res Volume: 99 Page(s): e2
    07/21/2006 Authors: O'Neill WC
  • An assessment of statin safety by nephrologists.
    Am J Cardiol Volume: 97 Page(s): 82C - 85C
    04/17/2006 Authors: Kasiske BL; Wanner C; O'Neill WC; National Lipid Association Statin Safety Task Force Kidney Expert Panel
  • Chemical and hormonal determinants of vascular calcification in vitro.
    Kidney Int Volume: 69 Page(s): 1464 - 1470
    04/01/2006 Authors: Lomashvili K; Garg P; O'Neill WC
  • B-mode sonography in acute renal failure.
    Nephron Clin Pract Volume: 103 Page(s): c19 - c23
    01/01/2006 Authors: O'Neill WC
  • Familial risk of end-stage renal disease is associated with increased kidney volume.
    Volume: 54 Page(s): S312 - S312
    01/01/2006 Authors: Rishi R; Andone A; Yuan Y; Baumgarten D; O'Neill WC
  • Up-regulation of alkaline phosphatase in the aorta may contribute to vessel calcification in uremic rats.
    Volume: 54 Page(s): S312 - S312
    01/01/2006 Authors: Lomashvili KA; Garg P; O'Neill WC
  • Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP).
    Am J Kidney Dis Volume: 46 Page(s): 1058 - 1064
    12/01/2005 Authors: O'Neill WC; Robbin ML; Bae KT; Grantham JJ; Chapman AB; Guay-Woodford LM; Torres VE; King BF; Wetzel LH; Thompson PA
  • Reduced plasma pyrophosphate levels in hemodialysis patients.
    J Am Soc Nephrol Volume: 16 Page(s): 2495 - 2500
    08/01/2005 Authors: Lomashvili KA; Khawandi W; O'Neill WC
  • Correlation of renal histopathology with sonographic findings.
    Kidney Int Volume: 67 Page(s): 1515 - 1520
    04/01/2005 Authors: Moghazi S; Jones E; Schroepple J; Arya K; McClellan W; Hennigar RA; O'Neill WC
  • Rho protein modulates sodium, potassium and chloride cotransporter (NKCC1) activity in vascular smooth muscle cells
    Volume: 19 Page(s): A1155 - A1155
    03/07/2005 Authors: Garg P; O'Neill WC
  • Rho protein modulates sodium, potassium, and chloride cotransporter activity in vascular smooth muscle cells.
    JOURNAL OF INVESTIGATIVE MEDICINE Volume: 53 Page(s): S290 - S290
    01/01/2005 Authors: Garg P; O'Neill WC
  • Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin.
    J Am Soc Nephrol Volume: 15 Page(s): 1392 - 1401
    06/01/2004 Authors: Lomashvili KA; Cobbs S; Hennigar RA; Hardcastle KI; O'Neill WC
  • Reduced renal function in patients with simple renal cysts.
    Kidney Int Volume: 65 Page(s): 2303 - 2308
    06/01/2004 Authors: Al-Said J; Brumback MA; Moghazi S; Baumgarten DA; O'Neill WC
  • Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle.
    Am J Physiol Heart Circ Physiol Volume: 286 Page(s): H1552 - H1557
    04/01/2004 Authors: Jiang G; Akar F; Cobbs SL; Lomashvilli K; Lakkis R; Gordon FJ; Sutliff RL; O'Neill WC
  • Renal parenchymal volume: Dependence on age, sex, and race and correlation with renal function.
    Volume: 14 Page(s): 196A - 196A
    11/01/2003 Authors: Al-Said JM; Baumgarten DA; O'Neill WC
  • Sonographic measurement of the progression of autosomal-dominant polycystic kidney disease (ADPKD): The consortium for renal imaging studies in polycystic kidney disease (CRISP).
    Volume: 14 Page(s): 108A - 108A
    11/01/2003 Authors: O'Neill WC; Robbin ML; Bae KT; King BF; Baumgarten DA; Wetzel LH
  • The effect of calcium, phosphate, and calcitropic hormones on calcification of intact vessels in vitro.
    Volume: 14 Page(s): 691A - 691A
    11/01/2003 Authors: Lomashvili K; Cobbs SL; O'Neill WC
  • Imaging.
    Am J Kidney Dis Volume: 42 Page(s): 601 - 604
    09/01/2003 Authors: O'Neill WC; Baumgarten DA
  • Reduced kidney size in patients with simple renal cysts.
    Kidney Int Volume: 64 Page(s): 1059 - 1064
    09/01/2003 Authors: Al-Said J; O'Neill WC
  • Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort.
    Kidney Int Volume: 64 Page(s): 1035 - 1045
    09/01/2003 Authors: Chapman AB; Guay-Woodford LM; Grantham JJ; Torres VE; Bae KT; Baumgarten DA; Kenney PJ; King BF; Glockner JF; Wetzel LH
  • Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle.
    Hypertension Volume: 41 Page(s): 1131 - 1135
    05/01/2003 Authors: Jiang G; Cobbs S; Klein JD; O'Neill WC
  • Nephron number and primary hypertension
    NEW ENGLAND JOURNAL OF MEDICINE Volume: 348 Page(s): 1718 - 1718
    04/24/2003 Authors: O'Neill WC
  • Nephron number and primary hypertension.
    N Engl J Med Volume: 348 Page(s): 1717 - 1719
    04/24/2003 Authors: Johnson RJ; Rodrguez-Iturbe B; Herrera-Acosta J
  • Nephron number and primary hypertension.
    N Engl J Med Volume: 348 Page(s): 1717 - 1719
    04/24/2003 Authors: O'Neill WC
  • Pyrophosphate (PPi) but not osteopontin (OPN) is an endogenous inhibitor of vascular calcification
    Volume: 17 Page(s): A1197 - A1197
    03/17/2003 Authors: Lomashvili K; Cobbs S; Hardcastle KI; Hennigar RA; O'Neill WC
  • Na-K-2Cl cotransporter NKCC1 in vascular smooth muscle: tonic regulation by aldosterone and blood pressure
    Volume: 17 Page(s): A1235 - A1235
    03/17/2003 Authors: Cobbs SL; Lomashvili K; O'Neill WC
  • Guidelines for training, certification, and accreditation for Hemodialysis vascular access and endovascular procedures
    SEMINARS IN DIALYSIS Volume: 16 Page(s): 173 - 176
    03/01/2003 Authors: Beathard GA; Work J; Jackson J; Levine MI; Rasmussen R; Schon D
  • Guidelines for training, certification, and accreditation for hemodialysis vascular access and endovascular procedures. American Society of Diagnostic and Interventional Nephrology.
    Semin Dial Volume: 16 Page(s): 173 - 176
    01/01/2003 Authors: American Society of Diagnostic and Interventional Nephrology
  • Guidelines for training, certification, and accreditation in renal sonography
    SEMINARS IN DIALYSIS Volume: 15 Page(s): 442 - 444
    11/01/2002 Authors: O'Neill WC
  • Kidney cysts as a marker of early renal failure.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 256A - 256A
    09/01/2002 Authors: Brumback MB; Moghazi S; Baumgarten DA; O'Neill WC
  • Blood pressure regulates the Na-K-2Cl cotransporter NKCC1 in vascular smooth muscle.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 332A - 332A
    09/01/2002 Authors: Jiang GR; Akar F; Cobbs S; Lomashvilli K; Sutliff R; Lakkis R; O'Neill WC
  • Upregulation of vascular osteopontin in chronic renal failure.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 260A - 260A
    09/01/2002 Authors: Lomashvili KA; Cobbs S; O'Neill WC
  • Comparison of ultrasound (US) and magnetic resonance (MR) imaging for measurements of renal size and cyst involvement in autosomal dominant polycystic kidney disease (ADPKD). The consortium for renal imaging in polycystic kidney disease (CRISP).
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Page(s): 506A - 506A
    09/01/2002 Authors: O'Neill WC; Robbin ML; Arya K; Thompson P; Bae T
  • Seminars in nephrology. Introduction.
    Semin Nephrol Volume: 22 Page(s): 181 - 182
    05/01/2002 Authors: O'Neill WC
  • Sonography of the kidney and urinary tract.
    Semin Nephrol Volume: 22 Page(s): 242 - 253
    05/01/2002 Authors: O'Neill WC
  • Ultrasonography in renal transplantation.
    Am J Kidney Dis Volume: 39 Page(s): 663 - 678
    04/01/2002 Authors: O'neill WC; Baumgarten DA
  • Regulation of the Na-K-2Cl cotransporter NKCC1 by a volume-sensitive MKK7-JNK1 MAP kinase cascade.
    FASEB JOURNAL Volume: 16 Page(s): A57 - A57
    03/20/2002 Authors: Cobbs SL; O'Neill WC
  • Guidelines for training, certification, and accreditation in placement of permanent tunneled and cuffed peritoneal dialysis catheters.
    Semin Dial Volume: 15 Page(s): 440 - 442
    01/01/2002 Authors: American Society of Diagnostic and Interventional Nephrology
  • Growth factors stimulate the Na-K-2Cl cotransporter NKCC1 through a novel Cl(-)-dependent mechanism.
    Am J Physiol Cell Physiol Volume: 281 Page(s): C1948 - C1953
    12/01/2001 Authors: Jiang G; Klein JD; O'Neill WC
  • Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle.
    Am J Physiol Cell Physiol Volume: 281 Page(s): C579 - C584
    08/01/2001 Authors: Akar F; Jiang G; Paul RJ; O'Neill WC
  • Do dialysis patients need a "new nephrologist"? Reply
    AMERICAN JOURNAL OF KIDNEY DISEASES Volume: 37 Page(s): 1109 - 1110
    05/01/2001 Authors: O'Neill WC
  • Do dialysis patients need a "new nephrologist"?
    Am J Kidney Dis Volume: 37 Page(s): 1108 - 1110
    05/01/2001 Authors: Mickley V; Polo JR; Bourquelot P; Board of the Vascular Access Society
  • How echogenic is echogenic? Quantitative acoustics of the renal cortex.
    Am J Kidney Dis Volume: 37 Page(s): 706 - 711
    04/01/2001 Authors: Manley JA; O'Neill WC
  • Emergence of interventional nephrology as a new subspecialty.
    Am J Kidney Dis Volume: 37 Page(s): 876 - 877
    04/01/2001 Authors: Vesely T
  • Sonographic evaluation of renal failure.
    Am J Kidney Dis Volume: 35 Page(s): 1021 - 1038
    06/01/2000 Authors: O'Neill WC
  • Bedside renal biopsy: ultrasound guidance by the nephrologist.
    Am J Kidney Dis Volume: 34 Page(s): 955 - 959
    11/01/1999 Authors: Nass K; O'Neill WC
  • JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl cotransporter in vitro.
    Am J Physiol Volume: 277 Page(s): C425 - C431
    09/01/1999 Authors: Klein JD; Lamitina ST; O'Neill WC
  • Contractile regulation of the Na-K-2Cl cotransporter
    JOURNAL OF GENERAL PHYSIOLOGY Volume: 114 Page(s): 17A - 18A
    07/01/1999 Authors: Akar F; Paul RJ; O'Neill WC
  • Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl- cotransporter in rat aorta.
    Am J Physiol Volume: 276 Page(s): C1383 - C1390
    06/01/1999 Authors: Akar F; Skinner E; Klein JD; Jena M; Paul RJ; O'Neill WC
  • Physiological significance of volume-regulatory transporters.
    Am J Physiol Volume: 276 Page(s): C995 - C1011
    05/01/1999 Authors: O'Neill WC
  • Volume sensitive phosphorylation of NKCC1 in vitro by terminal c-jun kinase.
    FASEB JOURNAL Volume: 13 Page(s): A711 - A711
    03/15/1999 Authors: Klein JD; Lamitina ST; O'Neill WC
  • Renal ultrasonography: a procedure for nephrologists.
    Am J Kidney Dis Volume: 30 Page(s): 579 - 585
    10/01/1997 Authors: O'Neill WC
  • A volume-sensitive, IP3-insensitive Ca2+ store in vascular endothelial cells.
    Am J Physiol Volume: 273 Page(s): C316 - C322
    07/01/1997 Authors: Jena M; Minore JF; O'Neill WC
  • Shrinkage-induced activation of Na+/H+ exchange: role of cell density and myosin light chain phosphorylation.
    Am J Physiol Volume: 272 Page(s): C1968 - C1979
    06/01/1997 Authors: Shrode LD; Klein JD; Douglas PB; O'Neill WC; Putnam RW
  • Volume-sensitive myosin phosphorylation in vascular endothelial cells: correlation with Na-K-2Cl cotransport.
    Am J Physiol Volume: 269 Page(s): C1524 - C1531
    12/01/1995 Authors: Klein JD; O'Neill WC
  • Flow-mediated NO release from endothelial cells is independent of K+ channel activation or intracellular Ca2+.
    Am J Physiol Volume: 269 Page(s): C863 - C869
    10/01/1995 Authors: O'Neill WC
  • Shrinkage-induced activation of Na+/H+ exchange in primary rat astrocytes: role of myosin light-chain kinase.
    Am J Physiol Volume: 269 Page(s): C257 - C266
    07/01/1995 Authors: Shrode LD; Klein JD; O'Neill WC; Putnam RW
  • Functional coupling of Na(+)-K(+)-2Cl- cotransport and Ca(2+)-dependent K+ channels in vascular endothelial cells.
    Am J Physiol Volume: 269 Page(s): C267 - C274
    07/01/1995 Authors: O'Neill WC; Steinberg DF
  • Impaired cation transport in thymocytes of rats with chronic uremia includes the Na+/H+ antiporter.
    J Am Soc Nephrol Volume: 5 Page(s): 1689 - 1696
    03/01/1995 Authors: Greiber S; O'Neill WC; Mitch WE
  • Swelling-activated K+ fluxes in vascular endothelial cells: role of intracellular Ca2+.
    Am J Physiol Volume: 267 Page(s): C1535 - C1542
    12/01/1994 Authors: Perry PB; O'Neill WC
  • Excimer laser coronary angioplasty of aorto-ostial stenoses. Results of the excimer laser coronary angioplasty (ELCA) registry in the first 200 patients.
    Circulation Volume: 88 Page(s): 2049 - 2057
    11/01/1993 Authors: Eigler NL; Weinstock B; Douglas JS; Goldenberg T; Hartzler G; Holmes D; Leon M; Margolis J; Nobuyoshi M; O'Neill W
  • Swelling-activated K fluxes in vascular endothelial cells: volume regulation via K-Cl cotransport and K channels.
    Am J Physiol Volume: 265 Page(s): C763 - C769
    09/01/1993 Authors: Perry PB; O'Neill WC
  • Regulation by cell volume of Na(+)-K(+)-2Cl- cotransport in vascular endothelial cells: role of protein phosphorylation.
    J Membr Biol Volume: 132 Page(s): 243 - 252
    03/01/1993 Authors: Klein JD; Perry PB; O'Neill WC
  • Ca(2+)-dependent and Ca(2+)-permeable ion channels in aortic endothelial cells.
    Am J Physiol Volume: 263 Page(s): H1827 - H1838
    12/01/1992 Authors: Ling BN; O'Neill WC
  • Regulation of vascular endothelial cell volume by Na-K-2Cl cotransport.
    Am J Physiol Volume: 262 Page(s): C436 - C444
    02/01/1992 Authors: O'Neill WC; Klein JD
  • Swelling-activated K-Cl cotransport: metabolic dependence and inhibition by vanadate and fluoride.
    Am J Physiol Volume: 260 Page(s): C308 - C315
    02/01/1991 Authors: O'Neill WC
  • Effect of bradykinin on Na-K-2Cl cotransport and bumetanide binding in aortic endothelial cells.
    J Biol Chem Volume: 265 Page(s): 22238 - 22242
    12/25/1990 Authors: Klein JD; O'Neill WC
  • Lipoprotein disorders in diabetes mellitus.
    J Med Assoc Ga Volume: 78 Page(s): 771 - 773
    11/01/1989 Authors: O'Neill WC
  • Cl-dependent K transport in a pure population of volume-regulating human erythrocytes.
    Am J Physiol Volume: 256 Page(s): C858 - C864
    04/01/1989 Authors: O'Neill WC
  • Volume-sensitive, Cl-dependent K transport in resealed human erythrocyte ghosts.
    Am J Physiol Volume: 256 Page(s): C81 - C88
    01/01/1989 Authors: O'Neill WC
  • Volume-sensitive Cl-dependent K transport in human erythrocytes.
    Am J Physiol Volume: 253 Page(s): C883 - C888
    12/01/1987 Authors: O'Neill WC
  • The role of pump number and intracellular sodium and potassium in determining Na,K pump activity in human erythrocytes.
    Metabolism Volume: 36 Page(s): 345 - 350
    04/01/1987 Authors: O'Neill WC; Mikkelsen RB
  • Furosemide-sensitive Na+ and K+ transport and human erythrocyte volume.
    Biochim Biophys Acta Volume: 896 Page(s): 196 - 202
    01/26/1987 Authors: O'Neill WC; Mikkelsen RB
  • Accelerated bone formation causing profound hypocalcemia in acute leukemia.
    Ann Intern Med Volume: 105 Page(s): 375 - 378
    09/01/1986 Authors: Schenkein DP; O'Neill WC; Shapiro J; Miller KB
  • Evidence for the role of phospholipids in follicle-stimulating hormone binding to membrane-bound and soluble receptors from calf testis.
    Endocrinology Volume: 114 Page(s): 1135 - 1140
    04/01/1984 Authors: O'Neill WC; Reichert LE
  • Nerve conduction velocity in diabetes.
    N Engl J Med Volume: 309 Page(s): 190 - 192
    07/21/1983
  • Biochemical properties of the testicular follitropin-receptor system.
    Ann N Y Acad Sci Volume: 383 Page(s): 135 - 150
    01/01/1982 Authors: Reichert LE; Dias JA; Fletcher PW; O'Neill WC
  • Hypophosphatemia and glucose intolerance.
    N Engl J Med Volume: 304 Page(s): 731 - 732
    03/19/1981
  • Isolation and partial characterization of an acetylcholine receptor-enriched membrane fraction from skeletal muscle.
    J Recept Res Volume: 2 Page(s): 503 - 521
    01/01/1981 Authors: O'Neill WC; Mikkelsen RB
  • Obesity and overeating.
    N Engl J Med Volume: 299 Page(s): 422 - 423
    08/24/1978
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