William Lewis MD
Academic Appointment
- Professor of Pathology (tenured), Emory University School of Medicine
Education
Degrees
- MD from Boston University School of Medicine
- BS from University of Michigan
Research
Focus
- Mitochondrial DNA replication in disease: AIDS, congestive heart failure, hepatitis, renal failure - One classic biological teaching is that mitochondria are the "powerhouses of the cell", particularly in tissues that require significant energy, like heart, liver and muscle. The focus of the Lewis lab is the diverse effects of toxins on mitochondria structure and function.
Publications
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Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.
J Mol Cell Cardiol Volume: 116 Page(s): 29 - 40
03/01/2018 Authors: Shimizu Y; Polavarapu R; Eskla K-L; Nicholson CK; Koczor CA; Wang R; Lewis W; Shiva S; Lefer DJ; Calvert JW -
HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.
HIV Med Volume: 17 Page(s): 411 - 424
06/01/2016 Authors: Lambert CT; Sandesara PB; Hirsh B; Shaw LJ; Lewis W; Quyyumi AA; Schinazi RF; Post WS; Sperling L -
Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes.
Physiol Genomics Volume: 48 Page(s): 274 - 280
04/01/2016 Authors: Koczor CA; Ludlow I; Fields E; Jiao Z; Ludaway T; Russ R; Lewis W -
Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy.
J Mol Cell Cardiol Volume: 89 Page(s): 214 - 222
12/01/2015 Authors: Koshman YE; Sternlicht MD; Kim T; O'Hara CP; Koczor CA; Lewis W; Seeley TW; Lipson KE; Samarel AM -
Methamphetamine and HIV-Tat alter murine cardiac DNA methylation and gene expression.
Toxicol Appl Pharmacol Volume: 288 Page(s): 409 - 419
11/01/2015 Authors: Koczor CA; Fields E; Jedrzejczak MJ; Jiao Z; Ludaway T; Russ R; Shang J; Torres RA; Lewis W -
Ecstasy (MDMA) Alters Cardiac Gene Expression and DNA Methylation: Implications for Circadian Rhythm Dysfunction in the Heart.
Toxicol Sci Volume: 148 Page(s): 183 - 191
11/01/2015 Authors: Koczor CA; Ludlow I; Hight RS; Jiao Z; Fields E; Ludaway T; Russ R; Torres RA; Lewis W -
AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress.
Physiol Genomics Volume: 47 Page(s): 447 - 454
10/01/2015 Authors: Koczor CA; Jiao Z; Fields E; Russ R; Ludaway T; Lewis W -
Routine Screening for AMR By C4d Immunohistochemical Staining Is of Low Clinical Utility and Associated With High False-Positive Rates: A Single Center, 2 Year Analysis of 1518 Biopsies
Volume: 98 Page(s): 57 - 58
07/15/2014 Authors: Cole R; Lambert C; Lewis W; Jokhadar M; Smith A; Laskar S; Book W; Butler J; Gupta D -
Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy.
J Mol Cell Cardiol Volume: 72 Page(s): 281 - 291
07/01/2014 Authors: Koshman YE; Chu M; Kim T; Kalmanson O; Farjah M; Kumar M; Lewis W; Geenen DL; de Tombe P; Goldspink PH -
Routine Screening for AMR By C4d Immunohistochemical Staining Is of Low Clinical Utility and Associated With High False-Positive Rates: A Single Center, 2 Year Analysis of 1518 Biopsies
Volume: 14 Page(s): 57 - 58
06/01/2014 Authors: Cole R; Lambert C; Lewis W; Jokhadar M; Smith A; Laskar S; Book W; Butler J; Gupta D