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Profile

Wilbur Lam MD, PhD

  • SOM: Peds: Sickle Cell
    Professor
  • (404) 727-7473
  • wilbur.lam@emory.edu
  • Children's Healthcare of Atlanta Provider Profile
  • Lam Laboratory
  • Aflac Cancer & Blood Disorders Center
    Pediatrics
    2015 Uppergate Drive
Head shot of Wilbur Lam

Academic Appointment

  • Professor (Tenured) of Biomedical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
  • Professor (Tenured) of Pediatrics, Emory University

Education

Degrees

  • PhD from University of California
  • MD from Baylor College of Medicine
  • BA from Rice University

Research

Publications

  • High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array.
    APL Bioeng Volume: 9 Page(s): 026110
    06/01/2025 Authors: Viola H; Chen L-H; Jo S; Washington K; Selva C; Li A; Feng D; Giacalone V; Stephenson ST; Cottrill K
  • Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma.
    Biomaterials Volume: 316 Page(s): 123016
    05/01/2025 Authors: Ghoshal D; Petersen I; Ringquist R; Kramer L; Bhatia E; Hu T; Richard A; Park R; Corbin J; Agarwal S
  • Evaluating the Long-Term Benefits of Hydroxyurea in Pediatric Sickle Cell Anemia.
    Blood Adv
    04/16/2025 Authors: George PE; Kalmus GG; Lane PA; Lam WA; Lipscomb J; Howard D
  • Clinically relevant clot resolution via a thromboinflammation-on-a-chip.
    Nature
    04/02/2025 Authors: Qiu Y; Lin J; Wang A; Fang Z; Sakurai Y; Choi H; Williams EK; Hardy ET; Maher K; Coskun AF
  • Non - Invasive, smartphone image-based screening for sickle cell disease at the point-of-need.
    Heliyon Volume: 11 Page(s): e41830
    01/30/2025 Authors: Vital EF; LiCalzi MH; Mannino RG; McGann PT; Lam WA
  • Redefining the role of near-peer student volunteers in children's hospitals as paediatric patient mentors.
    Arch Dis Child Volume: 110 Page(s): 168 - 169
    01/24/2025 Authors: Hardy ET; Lam WA
  • Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA.
    PLoS One Volume: 20 Page(s): e0317972
    01/01/2025 Authors: Carmola LR; Roebling AD; Khosravi D; Langsjoen RM; Bombin A; Bixler B; Reid A; Chen C; Wang E; Lu Y
  • The Shift to Over-the-Counter Diagnostic Testing After RADx: Clinical, Regulatory, and Societal Implications.
    IEEE Open J Eng Med Biol Volume: 6 Page(s): 237 - 240
    01/01/2025 Authors: Downing M; Broach J; Lam W; Manabe YC; Martin G; McManus D; Murphy R; Soni A; Schachter S
  • Recommendations for defining disturbed flow as laminar, transitional, or turbulent in assays of hemostasis and thrombosis: communication from the ISTH SSC Subcommittee on Biorheology.
    J Thromb Haemost Volume: 23 Page(s): 345 - 358
    01/01/2025 Authors: Bark DL; Vital EF; Oury C; Lam WA; Gardiner EE
  • Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk.
    Nat Commun Volume: 15 Page(s): 10201
    11/25/2024 Authors: Oshinowo O; Copeland R; Patel A; Shaver N; Fay ME; Jeltuhin R; Xiang Y; Caruso C; Otumala AE; Hernandez S
  • Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease.
    Blood Volume: 144 Page(s): 2050 - 2062
    11/07/2024 Authors: Caruso C; Cheng X; Michaud ME; Szafraniec HM; Thomas BE; Fay ME; Mannino RG; Zhang X; Sakurai Y; Li W
  • Red blood cells: more than bags of hemoglobin.
    Blood Volume: 144 Page(s): 1467 - 1469
    10/03/2024 Authors: Maier CL; Lam WA
  • Diagnostic Utility of SARS-CoV-2 Nucleocapsid Antigenemia: A Meta-analysis.
    Open Forum Infect Dis Volume: 11 Page(s): ofae561
    10/01/2024 Authors: Damhorst GL; Martin SE; Wilber E; Verkerke H; Goodman M; Lam WA
  • PPAR/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension.
    Pulm Circ Volume: 14 Page(s): e12448
    10/01/2024 Authors: Lee DH; Kim M; Chang SS; Lee R; Jang AJ; Kim J; Ma J; Passineau MJ; Benza RL; Karmouty-Quintana H
  • Protocol for the creation and characterization of SARS-CoV-2 variant testing panels using remnant clinical samples for diagnostic assay testing.
    STAR Protoc Volume: 5 Page(s): 103146
    09/20/2024 Authors: Bassit L; Bowers HB; Greenleaf M; Sabino C; Lai E; Yu G; Piantadosi A; Wang E; O'Sick W; McLendon K
  • Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests.
    medRxiv
    08/20/2024 Authors: Jules E; Decker C; Bixler BJ; Ahmed A; Zhou ZC; Arora I; Tafesse H; Dakanay H; Bombin A; Wang E
  • BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.
    Am J Physiol Gastrointest Liver Physiol Volume: 327 Page(s): G1 - G15
    07/01/2024 Authors: Hellen DJ; Fay ME; Lee DH; Klindt-Morgan C; Bennett A; Pachura KJ; Grakoui A; Huppert SS; Dawson PA; Lam WA
  • Total Synthesis of a PSGL-1 Glycopeptide Analogue for Targeted Inhibition of P-Selectin.
    J Am Chem Soc Volume: 146 Page(s): 17414 - 17427
    06/26/2024 Authors: Dhakal B; Mandhapati A; Eradi P; Park S; Fibben K; Li K; DeYong A; Escopy S; Karki G; Park DD
  • Bridging the Divide: Unintended Consequences of the Shift to Home-Based Telemedicine.
    J Pediatr Volume: 269 Page(s): 113719
    06/01/2024 Authors: George PE; Kc D; Greenleaf M; Shah J; Lam WA; Hawkins CM
  • Redefining hyperviscosity in acute leukemia: Potential implications for red cell transfusions in the microvasculature.
    Am J Hematol Volume: 99 Page(s): 1103 - 1107
    06/01/2024 Authors: Musick JO; Williams EK; Fibben KS; Zhang DY; Caruso C; Sakurai Y; Tran R; Kemp ML; Lam WA
  • HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY.
    bioRxiv
    05/14/2024 Authors: Viola H; Chen L-H; Jo S; Washington K; Selva C; Li A; Feng D; Giacalone V; Stephenson ST; Cottrill K
  • Performance of the Xpert Mpox PCR assay with oropharyngeal, anorectal, and cutaneous lesion swab specimens.
    J Clin Virol Volume: 171 Page(s): 105659
    04/01/2024 Authors: Damhorst GL; McLendon K; Morales E; Solis ZM; Fitts E; Bowers HB; Sabino C; Sullivan J; Greenleaf M; Roback JD
  • Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant.
    Heliyon Volume: 10 Page(s): e27188
    03/30/2024 Authors: Damhorst GL; Lin J; Frediani JK; Sullivan JA; Westbrook A; McLendon K; Baugh TJ; O'Sick WH; Roback JD; Piantadosi AL
  • Multisite Mpox Infection and Viral Dynamics Among Persons With HIV in Metro Atlanta.
    J Infect Dis Volume: 229 Page(s): S213 - S218
    03/26/2024 Authors: Damhorst GL; Fujita AW; Fitts E; Szabo B; Bowers HB; Sabino C; Ahmed A; Wang E; Piantadosi A; McLendon K
  • Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies.
    Lab Chip Volume: 24 Page(s): 1867 - 1874
    03/26/2024 Authors: Gurkan UA; Wood DK; Carranza D; Herbertson LH; Diamond SL; Du E; Guha S; Di Paola J; Hines PC; Papautsky I
  • What's in a Name? Experimental Evidence of Gender Bias in Recommendation Letters Generated by ChatGPT.
    J Med Internet Res Volume: 26 Page(s): e51837
    03/05/2024 Authors: Kaplan DM; Palitsky R; Arconada Alvarez SJ; Pozzo NS; Greenleaf MN; Atkinson CA; Lam WA
  • The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs.
    Clin Infect Dis Volume: 78 Page(s): 301 - 307
    02/17/2024 Authors: Frediani JK; Parsons R; McLendon KB; Westbrook AL; Lam W; Martin G; Pollock NR
  • Engaging Cancer Care Physicians in Off-Label Drug Clinical Trials: Human-Centered Design Approach.
    JMIR Form Res Volume: 8 Page(s): e51604
    02/15/2024 Authors: Parsell MC; Greenleaf MN; Kombara GG; Sukhatme VP; Lam WA
  • Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report.
    Ann Am Thorac Soc Volume: 21 Page(s): 1 - 11
    01/01/2024 Authors: Vukmirovic M; Benam KH; Rose JJ; Turner S; Magin CM; Lagares D; Cohen AH; Kaminski N; Hirota JA; Maher TM
  • "An app is just available at all times"-the process and outcomes of converting the Georgia Tuberculosis Reference Guide into a mobile application.
    PLoS One Volume: 19 Page(s): e0298758
    01/01/2024 Authors: Arconada Alvarez SJ; Hoover AT; Greenleaf M; Ray SM; Schechter MC; Blumberg HM; Lam WA
  • Hemostasis-on-a-chip / incorporating the endothelium in microfluidic models of bleeding.
    Platelets Volume: 34 Page(s): 2185453
    12/01/2023 Authors: Sakurai Y; Hardy ET; Lam WA
  • Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders.
    Sci Adv Volume: 9 Page(s): eadj6423
    12/01/2023 Authors: Cheng X; Caruso C; Lam WA; Graham MD
  • Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against Wuhan-WT, delta and omicron BA1, BA2 spike trimers.
    iScience Volume: 26 Page(s): 108256
    11/17/2023 Authors: Cheedarla N; Verkerke HP; Potlapalli S; McLendon KB; Patel A; Frank F; O'Sick WH; Cheedarla S; Baugh TJ; Damhorst GL
  • Standardization and Comparison of Emergency Use Authorized COVID-19 Assays and Testing Laboratories.
    medRxiv
    11/08/2023 Authors: Rao A; Lin J; Parsons R; Greenleaf M; Westbrook A; Lai E; Bowers HB; McClendon K; O'Sick W; Baugh T
  • Probing interactions of red blood cells and contracting fibrin platelet clots.
    Biophys J Volume: 122 Page(s): 4123 - 4134
    11/07/2023 Authors: Sun Y; Le H; Lam WA; Alexeev A
  • Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA.
    medRxiv
    10/25/2023 Authors: Carmola LR; Roebling AD; Khosravi D; Langsjoen RM; Bombin A; Bixler B; Reid A; Chen C; Wang E; Lu Y
  • Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants.
    J Clin Microbiol Volume: 61 Page(s): e0013823
    10/24/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
  • A novel mobile health application to support cancer surveillance needs of patients and families with cancer predisposition syndromes.
    Pediatr Blood Cancer Volume: 70 Page(s): e30537
    10/01/2023 Authors: Alvarez SJA; Pencheva B; Westfall E; Mwalija C; Parsell M; Greenleaf M; Porter CC; Lam WA; Mannino RG; Mitchell SG
  • Prevalence of SARS-CoV-2 in hemoglobinopathies is modified by age and race.
    Blood Cells Mol Dis Volume: 102 Page(s): 102756
    09/01/2023 Authors: Frediani JK; Pak-Harvey E; Parsons R; Westbrook AL; O'Sick W; Martin GS; Lam WA; Levy JM
  • Respiratory Coinfections in Children With SARS-CoV-2.
    Pediatr Infect Dis J Volume: 42 Page(s): 774 - 780
    09/01/2023 Authors: Westbrook A; Wang T; Bhakta K; Sullivan J; Gonzalez MD; Lam W; Rostad CA
  • Why platelet mechanotransduction matters for hemostasis and thrombosis.
    J Thromb Haemost Volume: 21 Page(s): 2339 - 2353
    09/01/2023 Authors: Oshinowo O; Azer SS; Lin J; Lam WA
  • Wear With Care: A Call for Empirical Investigations of Adverse Outcomes of Consumer Health Wearables.
    Mayo Clin Proc Digit Health Volume: 1 Page(s): 413 - 418
    09/01/2023 Authors: Kaplan DM; Greenleaf M; Lam WA
  • Development of constitutively synergistic nanoformulations to enhance chemosensitivity in T-cell leukemia.
    J Control Release Volume: 361 Page(s): 470 - 482
    09/01/2023 Authors: Kelvin JM; Chimenti ML; Zhang DY; Williams EK; Moore SG; Humber GM; Baxter TA; Birnbaum LA; Qui M; Zecca H
  • Label-free microfluidic isolation of functional and viable lymphocytes from peripheral blood mononuclear cells.
    Biomicrofluidics Volume: 17 Page(s): 054102
    09/01/2023 Authors: Raj A; Ramirez K; Young KM; Stone N; Shankles P; Ali MNR; Compton AM; Lam W; Alexeev A; Sulchek T
  • iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays.
    Nat Commun Volume: 14 Page(s): 5022
    08/18/2023 Authors: Fay ME; Oshinowo O; Iffrig E; Fibben KS; Caruso C; Hansen S; Musick JO; Valdez JM; Azer SS; Mannino RG
  • Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.
    Thromb Haemost Volume: 123 Page(s): 808 - 839
    08/01/2023 Authors: Akbulut AC; Arisz RA; Baaten CCFMJ; Baidildinova G; Barakzie A; Bauersachs R; Ten Berg J; van den Broek WWA; de Boer HC; Bonifay A
  • ARE CHILDREN WITH SICKLE CELL DISEASE AT INCREASED RISK OF HARMS FROM AIR POLLUTION?
    Volume: 70 Page(s): S165 - S165
    06/01/2023 Authors: George P; Maillis A; Zhu Y; Liu Y; Lane P; Lam W; Lipscomb J; Ebelt S
  • Are children with sickle cell disease at particular risk from the harmful effects of air pollution? Evidence from a large, urban/peri-urban cohort.
    Pediatr Blood Cancer Page(s): e30453
    05/29/2023 Authors: George PE; Maillis A; Zhu Y; Liu Y; Lane PA; Lam W; Lipscomb J; Ebelt S
  • Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders.
    bioRxiv
    05/18/2023 Authors: Cheng X; Caruso C; Lam WA; Graham MD
  • Pivot, persevere, or perish: how Ellume Health overcame development and regulatory obstacles to become the first authorized over-the-counter COVID-19 test in the United States.
    Lab Chip Volume: 23 Page(s): 2366 - 2370
    05/16/2023 Authors: Greenleaf MN; Nehl E; Damhorst GL; Lam WA
  • The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs.
    medRxiv
    05/10/2023 Authors: Frediani JK; Parsons R; McLendon KB; Westbrook AL; Lam W; Martin G; Pollock NR
  • Hidden behind thromboinflammation: revealing the roles of von Willebrand factor in sickle cell disease pathophysiology.
    Curr Opin Hematol Volume: 30 Page(s): 86 - 92
    05/01/2023 Authors: Vital EF; Lam WA
  • SARS-CoV-2 molecular testing and whole genome sequencing following RNA recovery from used BinaxNOW COVID-19 antigen self tests.
    J Clin Virol Volume: 162 Page(s): 105426
    05/01/2023 Authors: Nguyen P-V; Carmola LR; Wang E; Bassit L; Rao A; Greenleaf M; Sullivan JA; Martin GS; Lam WA; Waggoner JJ
  • Investigation of Blood Plasma Viral Nucleocapsid Antigen as a Marker of Active Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Infection.
    Open Forum Infect Dis Volume: 10 Page(s): ofad226
    05/01/2023 Authors: Damhorst GL; Schoof N; Nguyen P-V; Verkerke H; Wilber E; McLendon K; O'Sick W; Baugh T; Cheedarla S; Cheedarla N
  • The critical role of engineering in the rapid development of COVID-19 diagnostics: Lessons from the RADx Tech Test Verification Core.
    Sci Adv Volume: 9 Page(s): eade4962
    04/07/2023 Authors: Mannino RG; Nehl EJ; Farmer S; Peagler AF; Parsell MC; Claveria V; Ku D; Gottfried DS; Chen H; Lam WA
  • Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
    Nat Commun Volume: 14 Page(s): 1638
    04/04/2023 Authors: Druzak S; Iffrig E; Roberts BR; Zhang T; Fibben KS; Sakurai Y; Verkerke HP; Rostad CA; Chahroudi A; Schneider F
  • Navigating the complexities of mobile medical app development from idea to launch, a guide for clinicians and biomedical researchers.
    BMC Med Volume: 21 Page(s): 109
    03/23/2023 Authors: Mannino RG; Arconada Alvarez SJ; Greenleaf M; Parsell M; Mwalija C; Lam WA
  • Compact and low-cost deep-ultraviolet microscope system for label-free molecular imaging and point-of-care hematological analysis.
    Biomed Opt Express Volume: 14 Page(s): 1245 - 1255
    03/01/2023 Authors: Gorti V; Kaza N; Williams EK; Lam WA; Robles FE
  • Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants.
    medRxiv
    02/10/2023 Authors: Rao A; Westbrook A; Bassit L; Parsons R; Fitts E; Greenleaf M; McLendon K; Sullivan JA; O'Sick W; Baugh T
  • SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents-Reply.
    JAMA Volume: 329 Page(s): 425 - 426
    02/07/2023 Authors: Waggoner JJ; Tyburski EA; Lam WA
  • SARS-CoV-2 Antigenemia is Associated With Pneumonia in Children But Lacks Sensitivity to Diagnose Acute Infection.
    Pediatr Infect Dis J Volume: 42 Page(s): 130 - 135
    02/01/2023 Authors: Damhorst GL; Verkerke HP; Harrington KRV; McLendon K; Lu A; Perez MA; Hussaini L; Anderson EJ; Stowell SR; Roback JD
  • Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.
    J Extracell Vesicles Volume: 12 Page(s): e12305
    02/01/2023 Authors: Li G; Chen T; Dahlman J; Eniola-Adefeso L; Ghiran IC; Kurre P; Lam WA; Lang JK; Marbn E; Martn P
  • Membrane curvature and PS localize coagulation proteins to filopodia and retraction fibers of endothelial cells.
    Blood Adv Volume: 7 Page(s): 60 - 72
    01/10/2023 Authors: Carman CV; Nikova DN; Sakurai Y; Shi J; Novakovic VA; Rasmussen JT; Lam WA; Gilbert GE
  • SARS-CoV-2 molecular testing and whole genome sequencing following RNA recovery from used BinaxNOW COVID-19 Antigen Self Tests.
    medRxiv
    01/09/2023 Authors: Nguyen P-V; Carmola LR; Wang E; Bassit L; Rao A; Greenleaf M; Sullivan JA; Martin GS; Lam WA; Waggoner JJ
  • Effect of swab pooling on the Accula point-of-care RT-PCR for SARS-CoV-2 detection.
    Front Microbiol Volume: 14 Page(s): 1219214
    01/01/2023 Authors: Lancelot M; Fibben K; Sullivan J; O'Sick W; McLendon K; Wu H; Rao A; Bassit LC; Greenleaf M; Miller P
  • Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels.
    Front Immunol Volume: 14 Page(s): 1226832
    01/01/2023 Authors: Golomingi M; Kohler J; Lamers C; Pouw RB; Ricklin D; Dob J; Gl P; Pl G; Kiss B; Dopler A
  • Lessons Learned from In-Person Conferences in the Times of COVID-19.
    Int J Environ Res Public Health Volume: 20
    12/28/2022 Authors: Ehteshami M; Edgar CL; Delgado Ayala LY; Hagan M; Martin GS; Lam W; Schinazi RF
  • Label-free deep-UV microscopy detection and grading of neutropenia using a passive microfluidic device.
    Opt Lett Volume: 47 Page(s): 6005 - 6008
    11/15/2022 Authors: Ojaghi A; Kendall Williams E; Kaza N; Gorti V; Choi H; Torey J; Wiley T; Turner B; Jackson S; Park S
  • Nucleocapsid Antigenemia Is a Marker of Acute SARS-CoV-2 Infection.
    J Infect Dis Volume: 226 Page(s): 1577 - 1587
    11/01/2022 Authors: Verkerke HP; Damhorst GL; Graciaa DS; McLendon K; O'Sick W; Robichaux C; Cheedarla N; Potlapalli S; Wu S-C; Harrington KRV
  • Hyperviscosity syndromes; hemorheology for physicians and the use of microfluidic devices.
    Curr Opin Hematol Volume: 29 Page(s): 290 - 296
    11/01/2022 Authors: Musick JO; Fibben KS; Lam WA
  • Subgenomic RNA Abundance Relative to Total Viral RNA Among Severe Acute Respiratory Syndrome Coronavirus 2 Variants.
    Open Forum Infect Dis Volume: 9 Page(s): ofac619
    11/01/2022 Authors: Su M; Ping S; Nguyen P-V; Rojas A; Hussaini L; Carmola LR; Taz A; Sullivan J; Martin GS; Piantadosi A
  • Predictive Value of Isolated Symptoms for Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children Tested During Peak Circulation of the Delta Variant.
    Clin Infect Dis Volume: 75 Page(s): 1131 - 1139
    09/30/2022 Authors: Westbrook AL; Benedit LC; Frediani JK; Griffiths MA; Khan NY; Levy JM; Morris CR; Rostad CA; Stone CL; Sullivan J
  • Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.
    Cell Volume: 185 Page(s): 3603 - 3616.e13
    09/15/2022 Authors: Frank F; Keen MM; Rao A; Bassit L; Liu X; Bowers HB; Patel AB; Cato ML; Sullivan JA; Greenleaf M
  • Concordance of SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents.
    JAMA Volume: 328 Page(s): 935 - 940
    09/13/2022 Authors: Waggoner JJ; Vos MB; Tyburski EA; Nguyen P-V; Ingersoll JM; Miller C; Sullivan J; Griffiths M; Stone C; Benoit M
  • Comparison of Mid-turbinate Nasal Swabs, Saliva, and Nasopharyngeal Swabs for SARS-CoV-2 Reverse Transcription-Polymerase Chain Reaction Testing in Pediatric Outpatients.
    Arch Pathol Lab Med Volume: 146 Page(s): 1056 - 1061
    09/01/2022 Authors: Vos MB; Gonzalez MD; Stone C; Cleeton R; Figueroa J; Jerris R; Park SI; Heilman S; Nayee R; Chahroudi A
  • Nucleocapsid Antigenemia in Patients Receiving Anti-CD20 Therapy With Protracted COVID-19.
    Open Forum Infect Dis Volume: 9 Page(s): ofac419
    08/01/2022 Authors: Wilber E; Piantadosi A; Babiker A; McLendon K; O'Sick W; Fitts E; Webster AS; Verkerke H; Kim JS; Phadke VK
  • Microfluidic methods to advance mechanistic understanding and translational research in sickle cell disease.
    Transl Res Volume: 246 Page(s): 1 - 14
    08/01/2022 Authors: Azul M; Vital EF; Lam WA; Wood DK; Beckman JD
  • Pathologic mechanobiological interactions between red blood cells and endothelial cells directly induce vasculopathy in iron deficiency anemia.
    iScience Volume: 25 Page(s): 104606
    07/15/2022 Authors: Caruso C; Fay ME; Cheng X; Liu AY; Park SI; Sulchek TA; Graham MD; Lam WA
  • INTRODUCING A BIOPHYSICAL PLATELET FUNCTION PANEL TO INVESTIGATE BLEEDING OF UNKNOWN CAUSE
    Volume: 69
    06/01/2022 Authors: Azer S; Oshinowo O; Fay M; Sakurai Y; Qiu Y; Bennett C; Meeks S; Brown M; Myers D; Lam W
  • Don't forget about human factors: Lessons learned from COVID-19 point-of-care testing.
    Cell Rep Methods Volume: 2 Page(s): 100222
    05/23/2022 Authors: Farmer S; Razin V; Peagler AF; Strickler S; Fain WB; Damhorst GL; Kempker RR; Pollock NR; Brand O; Seitter B
  • Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood.
    Lab Chip Volume: 22 Page(s): 1565 - 1575
    04/12/2022 Authors: Szafraniec HM; Valdez JM; Iffrig E; Lam WA; Higgins JM; Pearce P; Wood DK
  • Designing for simplicity: lessons from Mesa Biotech for microfluidic entrepreneurs and early-stage companies.
    Lab Chip Volume: 22 Page(s): 1469 - 1473
    04/12/2022 Authors: Greenleaf MN; Damhorst GL; Ku DN; Nehl EJ; Tyburski EA; Brand O; Martin GS; Lam WA
  • Building the foundation of health-related knowledge via near-peer education for children with sickle cell disease.
    Pediatr Blood Cancer Volume: 69 Page(s): e29566
    04/01/2022 Authors: Hardy ELT; Williams B; Harden C; Oshinowo O; Copeland R; Carden MA; Gee BE; Lam WA
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  • Integrated Microfluidic Automated Particle Tracking F:nables High-Throughput Cell Deformability Cytometry for Red Cell Disorders
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  • Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts.
    Proc Natl Acad Sci U S A Volume: 113 Page(s): 1987 - 1992
    02/23/2016 Authors: Fay ME; Myers DR; Kumar A; Turbyfield CT; Byler R; Crawford K; Mannino RG; Laohapant A; Tyburski EA; Sakurai Y
  • Clot Contraction-Mediated Erythrocyte Packing Is Significantly Altered in Sickle Cell Disease
    Volume: 126
    12/03/2015 Authors: Strauss H; Myers DR; Rollins MR; Weisel JW; Lam WA
  • Engineering a "Self -Healing" Hydrogel-Based Microvasculature-on-a-Chip for Investigating the Effects of Cellular and Biomolecular Interactions on Endothelial Permeability in Sickle Cell Disease
    Volume: 126
    12/03/2015 Authors: Qiu Y; Ahn B; Sakurai Y; Hansen C; Joiner CH; Ofori-Acquah SF; Lam WA
  • Vessel Geometry Interacts with Red Blood Cell Stiffness to Promote Endothelial Dysfunction in Sickle Cell Disease
    Volume: 126
    12/03/2015 Authors: Wang Y; Mannino RG; Myers DR; Li W; Joiner CH; Lam WA
  • Engineering a Valve-Regulated Endothelialized Microfluidic Device As an "in Vitro" Bleeding Time for Assessing Global Hemostasis
    Volume: 126
    12/03/2015 Authors: Sakurai Y; Hardy ET; Ahn B; Meeks SL; Baldwin WH; Jobe SM; Lam WA
  • Improving Lentiviral Transduction Efficiency with Microfluidic Systems
    Volume: 126
    12/03/2015 Authors: Tran R; Myers DR; Shields JE; Ahn B; Qiu Y; Hansen C; Sakurai Y; Moot R; Spencer HT; Doering CB
  • Characterizing Cellular Interactions Contributing to Vaso-Occlusion in Patients with Sickle Cell Disease Utilizing a Novel Endothelialized Microfluidic Device
    Volume: 126
    12/03/2015 Authors: Rollins MR; Ahn B; Sakurai Y; Lam WA
  • An accurate and inexpensive color-based assay for detecting severe anemia in a limited-resource setting.
    Am J Hematol Volume: 90 Page(s): 1122 - 1127
    12/01/2015 Authors: McGann PT; Tyburski EA; de Oliveira V; Santos B; Ware RE; Lam WA
  • Platelets and physics: How platelets "feel" and respond to their mechanical microenvironment.
    Blood Rev Volume: 29 Page(s): 377 - 386
    11/01/2015 Authors: Qiu Y; Ciciliano J; Myers DR; Tran R; Lam WA
  • Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin -chain crosslinking.
    Blood Volume: 126 Page(s): 1940 - 1948
    10/15/2015 Authors: Byrnes JR; Duval C; Wang Y; Hansen CE; Ahn B; Mooberry MJ; Clark MA; Johnsen JM; Lord ST; Lam WA
  • Platelets as "Micromachines" for Sensing and Actuation of Targeted Drug Delivery for Hemostatic Agents
    Volume: 21 Page(s): S396 - S396
    09/01/2015 Authors: Hansen CE; Sakurai Y; Lyon LA; Lam W
  • Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.
    Blood Volume: 126 Page(s): 817 - 824
    08/06/2015 Authors: Ciciliano JC; Sakurai Y; Myers DR; Fay ME; Hechler B; Meeks S; Li R; Dixon JB; Lyon LA; Gachet C
  • "Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions".
    Sci Rep Volume: 5 Page(s): 12401
    07/23/2015 Authors: Mannino RG; Myers DR; Ahn B; Wang Y; Margo Rollins; Gole H; Lin AS; Guldberg RE; Giddens DP; Timmins LH
  • Platelet geometry sensing spatially regulates -granule secretion to enable matrix self-deposition.
    Blood Volume: 126 Page(s): 531 - 538
    07/23/2015 Authors: Sakurai Y; Fitch-Tewfik JL; Qiu Y; Ahn B; Myers DR; Tran R; Fay ME; Ding L; Spearman PW; Michelson AD
  • Molecular characterization of gap junction mediated intercellular communication in platelets
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS Volume: 13 Page(s): 910 - 911
    06/01/2015 Authors: Vaiyapuri S; Bye A; Benn M; Sakurai Y; Lam W; Gibbins JM
  • The role of gap junctions in platelet function
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS Volume: 13 Page(s): 60 - 60
    06/01/2015 Authors: Vaiyapuri S; Bye A; Benn M; Sakurai Y; Lam W; Gibbins JM
  • Identifying and characterizing spontaneous cerebrovascular disease in a murine model of human sickle cell disease
    Volume: 169 Page(s): 23 - 24
    04/01/2015 Authors: Hyacinth HI; Sugihara CL; Kindy MS; Greenberg CS; Fay ME; Lam W; Archer DR; Adams RJ; Shih AY
  • Microfluidic cellular enrichment and separation through differences in viscoelastic deformation.
    Lab Chip Volume: 15 Page(s): 532 - 540
    01/21/2015 Authors: Wang G; Crawford K; Turbyfield C; Lam W; Alexeev A; Sulchek T
  • Platelet mechanosensing of collagen matrices.
    PLoS One Volume: 10 Page(s): e0126624
    01/01/2015 Authors: Kee MF; Myers DR; Sakurai Y; Lam WA; Qiu Y
  • Platelet Adhesion, Spreading and Activation Are Mediated By Mechanosensing of Matrix Stiffness
    Volume: 124
    12/06/2014 Authors: Qiu Y; Brown AC; Myers DR; Sakurai Y; Mannino R; Tran R; Ahn B; Hardy E; Kee MF; Kumar S
  • Platelet Mechanosensing of Collagen Matrices
    Volume: 124
    12/06/2014 Authors: Kee MF; Qiu Y; Myers DR; Sakurai Y; Lam WA
  • "Self-Deposition" of Matrix Proteins from Platelet alpha-Granules Enable Extended Adhesion and Spreading on Micron/Submicron-Scale Fibrinogen and Collagen Substrates.
    Volume: 124
    12/06/2014 Authors: Sakurai Y; Fitch-Tewfik JL; Qiu Y; Myers DR; Ahn B; Flaumenhaft R; Lam WA
  • An Accurate and Rapid Color-Based Point-of-Care Assay for the Detection of Severe Anemia in Low Resource Settings
    BLOOD Volume: 124
    12/06/2014 Authors: McGann PT; Tyburski E; de Oliveira V; Santos B; Ware RE; Lam WA
  • Investigating Platelet Interactions in Sickle Cell Disease Using a Novel Multi-Shear "Endothelialized" Microfluidic System
    BLOOD Volume: 124
    12/06/2014 Authors: Rollins MR; Ahn B; Sakurai Y; Ciciliano JC; Lam WA
  • Ultrasoft microgels displaying emergent platelet-like behaviours.
    Nat Mater Volume: 13 Page(s): 1108 - 1114
    12/01/2014 Authors: Brown AC; Stabenfeldt SE; Ahn B; Hannan RT; Dhada KS; Herman ES; Stefanelli V; Guzzetta N; Alexeev A; Lam WA
  • Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 14430 - 14435
    10/07/2014 Authors: Qiu Y; Brown AC; Myers DR; Sakurai Y; Mannino RG; Tran R; Ahn B; Hardy ET; Kee MF; Kumar S
  • Disposable platform provides visual and color-based point-of-care anemia self-testing.
    J Clin Invest Volume: 124 Page(s): 4387 - 4394
    10/01/2014 Authors: Tyburski EA; Gillespie SE; Stoy WA; Mannino RG; Weiss AJ; Siu AF; Bulloch RH; Thota K; Cardenas A; Session W
  • Factor XIII activity mediates red blood cell retention in venous thrombi.
    J Clin Invest Volume: 124 Page(s): 3590 - 3600
    08/01/2014 Authors: Aleman MM; Byrnes JR; Wang J-G; Tran R; Lam WA; Di Paola J; Mackman N; Degen JL; Flick MJ; Wolberg AS
  • Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo.
    Stem Cell Reports Volume: 3 Page(s): 60 - 72
    07/08/2014 Authors: Chinnadurai R; Garcia MA; Sakurai Y; Lam WA; Kirk AD; Galipeau J; Copland IB
  • Simplified prototyping of perfusable polystyrene microfluidics.
    Biomicrofluidics Volume: 8 Page(s): 046501
    07/01/2014 Authors: Tran R; Ahn B; Myers DR; Qiu Y; Sakurai Y; Moot R; Mihevc E; Trent Spencer H; Doering C; A Lam W
  • Capture of circulating melanoma cells using a microfluidic device
    Volume: 55
    04/01/2014 Authors: Zhang Q; You S; Lam WA; Ciciliano J; Kang S; Yang H; Grossniklaus HE
  • The platelet and the biophysical microenvironment: lessons from cellular mechanics.
    Thromb Res Volume: 133 Page(s): 532 - 537
    04/01/2014 Authors: Ciciliano JC; Tran R; Sakurai Y; Lam WA
  • Using microfluidics to investigate hematopoietic stem cell and microniche interactions at the single cell level.
    Methods Mol Biol Volume: 1185 Page(s): 223 - 233
    01/01/2014 Authors: Ahn B; Wang Z; Archer DR; Lam WA
  • New Insights Into The Mechanisms Of Ferric Chloride-Induced Thrombosis: a Reductionist Microfluidic Approach
    Volume: 122
    11/15/2013 Authors: Ciciliano JC; Myers DR; Fay ME; Sakurai Y; Li R; Lyon A; Lam WA
  • Mitochondrially mediated integrin IIb3 protein inactivation limits thrombus growth.
    J Biol Chem Volume: 288 Page(s): 30672 - 30681
    10/18/2013 Authors: Liu F; Gamez G; Myers DR; Clemmons W; Lam WA; Jobe SM
  • Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
    Blood Volume: 122 Page(s): 1695 - 1706
    09/05/2013 Authors: Chen Y; Aardema J; Kale S; Whichard ZL; Awomolo A; Blanchard E; Chang B; Myers DR; Ju L; Tran R
  • Imaging fusion of single vesicular stomatitis virus with supported lipid bilayers
    Volume: 42 Page(s): S102 - S102
    07/01/2013 Authors: Matos PM; Marin M; Ahn B; Lam W; Santos NC; Melikyan GB
  • Procoagulant activity at the margins of TNFa treated endothelial cells leads to pericellular fibrin deposition and anti-streptococcal function in flowing plasma
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS Volume: 11 Page(s): 518 - 518
    07/01/2013 Authors: Gilbert GE; Novakovic VA; Lu J; Shi J; Ahn B; Lam WA
  • Anionic lipids are required for vesicular stomatitis virus G protein-mediated single particle fusion with supported lipid bilayers.
    J Biol Chem Volume: 288 Page(s): 12416 - 12425
    05/03/2013 Authors: Matos PM; Marin M; Ahn B; Lam W; Santos NC; Melikyan GB
  • Biomechanics of haemostasis and thrombosis in health and disease: from the macro- to molecular scale.
    J Cell Mol Med Volume: 17 Page(s): 579 - 596
    05/01/2013 Authors: Tran R; Myers DR; Ciciliano J; Trybus Hardy EL; Sakurai Y; Ahn B; Qiu Y; Mannino RG; Fay ME; Lam WA
  • An "Endothelialized" Microfluidic System That Distinguishes Procoagulant Mechanisms in Arterial and Venous Thrombosis
    Volume: 120
    11/16/2012 Authors: Ahn B; Sakurai Y; Myers DR; Qiu Y; Hardy E; Tran R; Mannino R; Wolberg AS; Lam W
  • Endothelialized microfluidics for studying microvascular interactions in hematologic diseases.
    J Vis Exp
    06/22/2012 Authors: Myers DR; Sakurai Y; Tran R; Ahn B; Hardy ET; Mannino R; Kita A; Tsai M; Lam WA
  • In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology.
    J Clin Invest Volume: 122 Page(s): 408 - 418
    01/01/2012 Authors: Tsai M; Kita A; Leach J; Rounsevell R; Huang JN; Moake J; Ware RE; Fletcher DA; Lam WA
  • Measuring the Direct Effects of Sickle Cell Vaso-Occlusion on Endothelial Cells Using Microfluidic Technology
    Volume: 118 Page(s): 410 - 410
    11/18/2011 Authors: Myers DR; Sakurai Y; Chappa P; Barabino G; Archer DR; Lam W
  • A Novel Assay That Integrates the Effects of Multiple Agonists At the Single-Platelet Level
    Volume: 118 Page(s): 1402 - 1403
    11/18/2011 Authors: Sakurai Y; Myers DR; Kita A; Lam W
  • Platelet Sensing of Microenviornmental Geometry Guides Adhesion and Spreading: A Quantitative Study At the Single-Cell Level
    Volume: 118 Page(s): 956 - 957
    11/18/2011 Authors: Kita A; Sakurai Y; Myers DR; Rounsevell R; Seok TJ; Yu K; Huang J; Wu M; Fletcher D; Lam W
  • Nanomechanics of Platelet Contractility
    Volume: 118 Page(s): 959 - 960
    11/18/2011 Authors: Myers DR; Sulchek T; Lam W
  • Mitochondrially-Mediated Platelet Integrin Alpha(IIb)beta(3) Inactivation Limits Platelet Recruitment and Thrombus Growth
    Volume: 118 Page(s): 1400 - 1400
    11/18/2011 Authors: Liu F; Gamez G; Myers DR; Lam W; Jobe SM
  • Microenvironmental geometry guides platelet adhesion and spreading: a quantitative analysis at the single cell level.
    PLoS One Volume: 6 Page(s): e26437
    01/01/2011 Authors: Kita A; Sakurai Y; Myers DR; Rounsevell R; Huang JN; Seok TJ; Yu K; Wu MC; Fletcher DA; Lam WA
  • Mechanics and contraction dynamics of single platelets and implications for clot stiffening.
    Nat Mater Volume: 10 Page(s): 61 - 66
    01/01/2011 Authors: Lam WA; Chaudhuri O; Crow A; Webster KD; Li T-D; Kita A; Huang J; Fletcher DA
  • Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression.
    Mol Cancer Volume: 9 Page(s): 35
    02/10/2010 Authors: Lam WA; Cao L; Umesh V; Keung AJ; Sen S; Kumar S
  • Mobile phone based clinical microscopy for global health applications.
    PLoS One Volume: 4 Page(s): e6320
    07/22/2009 Authors: Breslauer DN; Maamari RN; Switz NA; Lam WA; Fletcher DA
  • Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells.
    Nat Methods Volume: 6 Page(s): 383 - 387
    05/01/2009 Authors: Chaudhuri O; Parekh SH; Lam WA; Fletcher DA
  • Increased leukaemia cell stiffness is associated with symptoms of leucostasis in paediatric acute lymphoblastic leukaemia.
    Br J Haematol Volume: 142 Page(s): 497 - 501
    07/01/2008 Authors: Lam WA; Rosenbluth MJ; Fletcher DA
  • Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry.
    Lab Chip Volume: 8 Page(s): 1062 - 1070
    07/01/2008 Authors: Rosenbluth MJ; Lam WA; Fletcher DA
  • DNA-coated AFM cantilevers for the investigation of cell adhesion and the patterning of live cells.
    Angew Chem Int Ed Engl Volume: 47 Page(s): 8473 - 8477
    01/01/2008 Authors: Hsiao SC; Crow AK; Lam WA; Bertozzi CR; Fletcher DA; Francis MB
  • Chemotherapy exposure increases leukemia cell stiffness.
    Blood Volume: 109 Page(s): 3505 - 3508
    04/15/2007 Authors: Lam WA; Rosenbluth MJ; Fletcher DA
  • Chemotherapy exposure decreases leukemia cell deformability as determined by atomic force microscopy: Implications for leukostasis in acute leukemia.
    Volume: 108 Page(s): 668A - 669A
    11/16/2006 Authors: Lam WA; Rosenbluth MJ; Fletcher DA
  • Epstein-Barr virus-associated B cell lymphoproliferative disease in a child with neonatal-onset multisystem inflammatory disease.
    Arthritis Rheum Volume: 55 Page(s): 823 - 825
    10/15/2006 Authors: Modica R; Emery H; Lam W; Hermiston M; Grenert J; Wirt M; von Scheven E
  • Force microscopy of nonadherent cells: a comparison of leukemia cell deformability.
    Biophys J Volume: 90 Page(s): 2994 - 3003
    04/15/2006 Authors: Rosenbluth MJ; Lam WA; Fletcher DA
  • Inheritance analysis of congenital left ventricular outflow tract obstruction malformations: Segregation, multiplex relative risk, and heritability.
    Am J Med Genet A Volume: 134A Page(s): 180 - 186
    04/15/2005 Authors: McBride KL; Pignatelli R; Lewin M; Ho T; Fernbach S; Menesses A; Lam W; Leal SM; Kaplan N; Schliekelman P
  • Echocardiographic evaluation of asymptomatic parental and sibling cardiovascular anomalies associated with congenital left ventricular outflow tract lesions.
    Pediatrics Volume: 114 Page(s): 691 - 696
    09/01/2004 Authors: Lewin MB; McBride KL; Pignatelli R; Fernbach S; Combes A; Menesses A; Lam W; Bezold LI; Kaplan N; Towbin JA
  • Inheritance analysis of congenital left ventricular outflow tract obstruction (LVOTO)
    Volume: 73 Page(s): 269 - 269
    11/01/2003 Authors: McBride K; Lewin M; Pignatelli R; Fernbach SD; Schliekelman P; Combes A; Menesses A; Lam W; Bezold LI; Kaplan N
  • Echocardiographic evaluation of asymptomatic parental and sibling cardiovascular anomalies associated with congenital left ventricular outflow tract lesions
    Volume: 53 Page(s): 38A - 38A
    04/01/2003 Authors: McBride KL; Lewin M; Fernbach S; Pignatelli R; Combes A; Menesses A; Ho T; Bezold L; Lam W; Kaplan N
  • Echocardiographic evaluation of parental and sibling risk associated with pediatric left ventricular outflow tract lesions.
    Volume: 71 Page(s): 211 - 211
    10/01/2002 Authors: McBride KL; Lewin MB; Pignatelli R; Fernbach SD; Combes A; Lam W; Bezold L; Ho T; Craigen W; Kaplan N
  • Influence of religious and spiritual values on the willingness of Chinese-Americans to donate organs for transplantation.
    Clin Transplant Volume: 14 Page(s): 449 - 456
    10/01/2000 Authors: Lam WA; McCullough LB
  • ENDOTHELIALIZED MICROSCALE CULTURE SYSTEMS: A NOVEL PLATFORM FOR TUMOR MICROENVIRONMENT STUDIES

    Authors: Mitchell S; Qiu Y; Sakurai Y; Lam W
  • A NOVEL MOBILE APP TO FACILITATE SURVEILLANCE PROTOCOL ADHERENCE IN CANCER PREDISPOSITION PATIENTS

    Authors: Mitchell S; Alvarez SA; Pencheva B; Mwalija C; Parsell M; Greenleaf M; Porter C; Lam W; Mannino R
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