Publications

• Poor vaccine responders mask the true trend in vaccine effectiveness against progression to severe disease.
  Vaccine Volume: 43 Page(s): 126516
  01/01/2025 Authors: Dean NE; Halloran ME; Zarnitsyna VI
• A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates.
  Sci Transl Med Volume: 16 Page(s): eadn6605
  07/31/2024 Authors: Arunachalam PS; Ha N; Dennison SM; Spreng RL; Seaton KE; Xiao P; Feng Y; Zarnitsyna VI; Kazmin D; Hu M
• Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity.
  JCI Insight Volume: 9
  06/11/2024 Authors: Pan Y-G; Bartolo L; Xu R; Patel BV; Zarnitsyna VI; Su LF
• Infants and young children generate more durable antibody responses to SARS-CoV-2 infection than adults.
  iScience Volume: 26 Page(s): 107967
  10/20/2023 Authors: Joshi D; Nyhoff LE; Zarnitsyna VI; Moreno A; Manning K; Linderman S; Burrell AR; Stephens K; Norwood C; Mantus G
• Competing Heterogeneities in Vaccine Effectiveness Estimation.
  Vaccines (Basel) Volume: 11
  08/01/2023 Authors: Nikas A; Ahmed H; Zarnitsyna VI
• When does humoral memory enhance infection?
  PLoS Comput Biol Volume: 19 Page(s): e1011377
  08/01/2023 Authors: Nikas A; Ahmed H; Moore MR; Zarnitsyna VI; Antia R
• Durability of immune responses to mRNA booster vaccination against COVID-19.
  J Clin Invest Volume: 133
  05/15/2023 Authors: Arunachalam PS; Lai L; Samaha H; Feng Y; Hu M; Hui HS-Y; Wali B; Ellis M; Davis-Gardner ME; Huerta C
• Estimating Waning of Vaccine Effectiveness: A Simulation Study.
  Clin Infect Dis Volume: 76 Page(s): 479 - 486
  02/08/2023 Authors: Nikas A; Ahmed H; Zarnitsyna VI
• Antibody Response to COVID-19 mRNA Vaccine in Patients With Lung Cancer After Primary Immunization and Booster: Reactivity to the SARS-CoV-2 WT Virus and Omicron Variant.
  J Clin Oncol Volume: 40 Page(s): 3808 - 3816
  11/20/2022 Authors: Valanparambil RM; Carlisle J; Linderman SL; Akthar A; Millett RL; Lai L; Chang A; McCook-Veal AA; Switchenko J; Nasti TH
• Compositional modelling of immune response and virus transmission dynamics.
  Philos Trans A Math Phys Eng Sci Volume: 380 Page(s): 20210307
  10/03/2022 Authors: Waites W; Cavaliere M; Danos V; Datta R; Eggo RM; Hallett TB; Manheim D; Panovska-Griffiths J; Russell TW; Zarnitsyna VI
• Humoral Responses Against SARS-CoV-2 and Variants of Concern After mRNA Vaccines in Patients With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia.
  J Clin Oncol Volume: 40 Page(s): 3020 - 3031
  09/10/2022 Authors: Chang A; Akhtar A; Linderman SL; Lai L; Orellana-Noia VM; Valanparambil R; Ahmed H; Zarnitsyna VI; McCook-Veal AA; Switchenko JM
• Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine.
  Sci Transl Med Volume: 14 Page(s): eabq4130
  08/17/2022 Authors: Arunachalam PS; Feng Y; Ashraf U; Hu M; Walls AC; Edara VV; Zarnitsyna VI; Aye PP; Golden N; Miranda MC
• Modeling suggests that multiple immunizations or infections will reveal the benefits of updating SARS-CoV-2 vaccines.
  bioRxiv
  05/23/2022 Authors: Desikan R; Linderman SL; Davis C; Zarnitsyna V; Ahmed H; Antia R
• Persistence of Virus-Specific Antibody after Depletion of Memory B Cells.
  J Virol Volume: 96 Page(s): e0002622
  05/11/2022 Authors: Langley WA; Wieland A; Ahmed H; Rasheed MAU; Davis CW; Sewatanon J; Mueller SN; Shlomchik MJ; Zarnitsyna VI; Antia R
• Pre-existing SARS-CoV-2 immunity influences potency, breadth, and durability of the humoral response to SARS-CoV-2 vaccination.
  Cell Rep Med Volume: 3 Page(s): 100603
  04/19/2022 Authors: Mantus G; Nyhoff LE; Edara V-V; Zarnitsyna VI; Ciric CR; Flowers MW; Norwood C; Ellis M; Hussaini L; Manning KE
• Durability of immune responses to the BNT162b2 mRNA vaccine.
  Med Volume: 3 Page(s): 25 - 27
  01/14/2022 Authors: Suthar MS; Arunachalam PS; Hu M; Reis N; Trisal M; Raeber O; Chinthrajah S; Davis-Gardner ME; Manning K; Mudvari P
• Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response.
  Cell Host Microbe Volume: 30 Page(s): 83 - 96.e4
  01/12/2022 Authors: Lin C-Y; Wolf J; Brice DC; Sun Y; Locke M; Cherry S; Castellaw AH; Wehenkel M; Crawford JC; Zarnitsyna VI
• Vaccine models predict rules for updating vaccines against evolving pathogens such as SARS-CoV-2 and influenza in the context of pre-existing immunity.
  Front Immunol Volume: 13 Page(s): 985478
  01/01/2022 Authors: Desikan R; Linderman SL; Davis C; Zarnitsyna VI; Ahmed H; Antia R
• Influenza Immunization in the Context of Preexisting Immunity.
  Cold Spring Harb Perspect Med Volume: 11
  11/01/2021 Authors: Linderman SL; Ellebedy AH; Davis C; Eberhardt CS; Antia R; Ahmed R; Zarnitsyna VI
• Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination.
  PLoS Comput Biol Volume: 17 Page(s): e1009468
  10/01/2021 Authors: Zarnitsyna VI; Akondy RS; Ahmed H; McGuire DJ; Zarnitsyn VG; Moore M; Johnson PLF; Ahmed R; Li KW; Hellerstein MK
• Advancing therapies for viral infections using mechanistic computational models of the dynamic interplay between the virus and host immune response.
  Curr Opin Virol Volume: 50 Page(s): 103 - 109
  10/01/2021 Authors: Zarnitsyna VI; Gianlupi JF; Hagar A; Sego TJ; Glazier JA
• The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin L2 on neutrophils.
  J Cell Sci Volume: 134
  09/15/2021 Authors: Zhou F; Zhang F; Zarnitsyna VI; Doudy L; Yuan Z; Li K; McEver RP; Lu H; Zhu C
• Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and Tcells.
  Cell Rep Med Volume: 2 Page(s): 100354
  07/20/2021 Authors: Cohen KW; Linderman SL; Moodie Z; Czartoski J; Lai L; Mantus G; Norwood C; Nyhoff LE; Edara VV; Floyd K
• Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19.
  N Engl J Med Volume: 384 Page(s): 2259 - 2261
  06/10/2021 Authors: Doria-Rose N; Suthar MS; Makowski M; O'Connell S; McDermott AB; Flach B; Ledgerwood JE; Mascola JR; Graham BS; Lin BC
• Vaccination reshapes the virus-specific T cell repertoire in unexposed adults.
  Immunity Volume: 54 Page(s): 1245 - 1256.e5
  06/08/2021 Authors: Pan Y-G; Aiamkitsumrit B; Bartolo L; Wang Y; Lavery C; Marc A; Holec PV; Rappazzo CG; Eilola T; Gimotty PA
• Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans.
  Proc Natl Acad Sci U S A Volume: 117 Page(s): 17957 - 17964
  07/28/2020 Authors: Ellebedy AH; Nachbagauer R; Jackson KJL; Dai Y-N; Han J; Alsoussi WB; Davis CW; Stadlbauer D; Rouphael N; Chromikova V
• Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?
  J Virol Volume: 93
  03/15/2019 Authors: Li Z-RT; Zarnitsyna VI; Lowen AC; Weissman D; Koelle K; Kohlmeier JE; Antia R
• Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design.
  PLoS Comput Biol Volume: 14 Page(s): e1006505
  10/01/2018 Authors: Handel A; Li Y; McKay B; Pawelek KA; Zarnitsyna V; Antia R
• Intermediate levels of vaccination coverage may minimize seasonal influenza outbreaks.
  PLoS One Volume: 13 Page(s): e0199674
  01/01/2018 Authors: Zarnitsyna VI; Bulusheva I; Handel A; Longini IM; Halloran ME; Antia R
• Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza.
  PLoS Pathog Volume: 12 Page(s): e1005692
  06/01/2016 Authors: Zarnitsyna VI; Lavine J; Ellebedy A; Ahmed R; Antia R
• Mathematical Model Reveals the Role of Memory CD8 T Cell Populations in Recall Responses to Influenza.
  Front Immunol Volume: 7 Page(s): 165
  01/01/2016 Authors: Zarnitsyna VI; Handel A; McMaster SR; Hayward SL; Kohlmeier JE; Antia R
• Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease.
  J Immunol Volume: 195 Page(s): 4162 - 4170
  11/01/2015 Authors: Hood JD; Zarnitsyna VI; Zhu C; Evavold BD
• Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza.
  Philos Trans R Soc Lond B Biol Sci Volume: 370
  09/05/2015 Authors: Zarnitsyna VI; Ellebedy AH; Davis C; Jacob J; Ahmed R; Antia R
• Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
  Nat Commun Volume: 5 Page(s): 5624
  11/27/2014 Authors: Casas J; Brzostek J; Zarnitsyna VI; Hong J-S; Wei Q; Hoerter JAH; Fu G; Ampudia J; Zamoyska R; Zhu C
• Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells.
  J Immunol Volume: 193 Page(s): 68 - 76
  07/01/2014 Authors: Pryshchep S; Zarnitsyna VI; Hong J; Evavold BD; Zhu C
• How sticky should a virus be? The impact of virus binding and release on transmission fitness using influenza as an example.
  J R Soc Interface Volume: 11 Page(s): 20131083
  03/06/2014 Authors: Handel A; Akin V; Pilyugin SS; Zarnitsyna V; Antia R
• Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire.
  Front Immunol Volume: 4 Page(s): 485
  12/26/2013 Authors: Zarnitsyna VI; Evavold BD; Schoettle LN; Blattman JN; Antia R
• Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network.
  Immunol Rev Volume: 251 Page(s): 49 - 64
  01/01/2013 Authors: Zhu C; Jiang N; Huang J; Zarnitsyna VI; Evavold BD
• P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces.
  PLoS One Volume: 8 Page(s): e57202
  01/01/2013 Authors: Zhang Y; Jiang N; Zarnitsyna VI; Klopocki AG; McEver RP; Zhu C
• T cell triggering: insights from 2D kinetics analysis of molecular interactions.
  Phys Biol Volume: 9 Page(s): 045005
  08/01/2012 Authors: Zarnitsyna V; Zhu C
• Insights into T cell recognition of antigen: significance of two-dimensional kinetic parameters.
  Front Immunol Volume: 3 Page(s): 86
  01/01/2012 Authors: Edwards LJ; Zarnitsyna VI; Hood JD; Evavold BD; Zhu C
• Adhesion frequency assay for in situ kinetics analysis of cross-junctional molecular interactions at the cell-cell interface.
  J Vis Exp Page(s): e3519
  11/02/2011 Authors: Zarnitsyna VI; Zhu C
• Regulation of catch bonds by rate of force application.
  J Biol Chem Volume: 286 Page(s): 32749 - 32761
  09/16/2011 Authors: Sarangapani KK; Qian J; Chen W; Zarnitsyna VI; Mehta P; Yago T; McEver RP; Zhu C
• The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.
  Nature Volume: 464 Page(s): 932 - 936
  04/08/2010 Authors: Huang J; Zarnitsyna VI; Liu B; Edwards LJ; Jiang N; Evavold BD; Zhu C
• Measuring Receptor-Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods.
  Cell Mol Bioeng Volume: 1 Page(s): 276 - 288
  12/01/2008 Authors: Chen W; Zarnitsyna VI; Sarangapani KK; Huang J; Zhu C
• Binary Time Series Modeling with Application to Adhesion Frequency Experiments.
  J Am Stat Assoc Volume: 103 Page(s): 1248 - 1259
  09/01/2008 Authors: Hung Y; Zarnitsyna V; Zhang Y; Zhu C; Wu CFJ
• A coupled diffusion-kinetics model for analysis of contact-area FRAP experiment.
  Biophys J Volume: 95 Page(s): 910 - 919
  07/01/2008 Authors: Wu J; Fang Y; Zarnitsyna VI; Tolentino TP; Dustin ML; Zhu C
• Measuring diffusion and binding kinetics by contact area FRAP.
  Biophys J Volume: 95 Page(s): 920 - 930
  07/01/2008 Authors: Tolentino TP; Wu J; Zarnitsyna VI; Fang Y; Dustin ML; Zhu C
• Mechanisms for flow-enhanced cell adhesion.
  Ann Biomed Eng Volume: 36 Page(s): 604 - 621
  04/01/2008 Authors: Zhu C; Yago T; Lou J; Zarnitsyna VI; McEver RP
• Memory in receptor-ligand-mediated cell adhesion.
  Proc Natl Acad Sci U S A Volume: 104 Page(s): 18037 - 18042
  11/13/2007 Authors: Zarnitsyna VI; Huang J; Zhang F; Chien Y-H; Leckband D; Zhu C
• Transport governs flow-enhanced cell tethering through L-selectin at threshold shear.
  Biophys J Volume: 92 Page(s): 330 - 342
  01/01/2007 Authors: Yago T; Zarnitsyna VI; Klopocki AG; McEver RP; Zhu C
• Flow-enhanced adhesion regulated by a selectin interdomain hinge.
  J Cell Biol Volume: 174 Page(s): 1107 - 1117
  09/25/2006 Authors: Lou J; Yago T; Klopocki AG; Mehta P; Chen W; Zarnitsyna VI; Bovin NV; Zhu C; McEver RP
• [Consideration of a priori information and type of an experimental error using the method of system identification based on the minimal quadratic discrepancy criterion].
  Biofizika Volume: 50 Page(s): 329 - 334
  01/01/2005 Authors: Karnaukhov AV; Karnaukhova EV; Zarnitsyna VI
• Tissue factor pathway inhibitor: a possible mechanism of action.
  Eur J Biochem Volume: 269 Page(s): 2016 - 2031
  04/01/2002 Authors: Panteleev MA; Zarnitsina VI; Ataullakhanov FI
• Dynamics of spatially nonuniform patterning in the model of blood coagulation.
  Chaos Volume: 11 Page(s): 57 - 70
  03/01/2001 Authors: Zarnitsina VI; Ataullakhanov FI; Lobanov AI; Morozova OL
• A mathematical model for the spatio-temporal dynamics of intrinsic pathway of blood coagulation. II. Results.
  Thromb Res Volume: 84 Page(s): 333 - 344
  12/01/1996 Authors: Zarnitsina VI; Pokhilko AV; Ataullakhanov FI
• A mathematical model for the spatio-temporal dynamics of intrinsic pathway of blood coagulation. I. The model description.
  Thromb Res Volume: 84 Page(s): 225 - 236
  11/15/1996 Authors: Zarnitsina VI; Pokhilko AV; Ataullakhanov FI