Victor Faundez Dr
- Department of Cell Biology
Professor
- (404) 727-3945
- vfaunde@emory.edu
- Google Scholar
- Pubmed
- Publications
- Cell Biology
- Faundez Lab
- Google Scholar
-
615 Michael Street Room 446
Overview
Research Focus
We are interested in understanding complex neurological disorders using cell biology, mouse and Drosophila genetic, and systems biology tools. We are focused on microdeletion and the Rett syndromes, genetic defects of human copper transporters, and mitochondrial transporters. All these genetic defects cause neurodevelopmental and neurodegenerative phenotypes in humans. We have a particular interest on understanding how diverse pathways and organelles interact to specify synapse development and function .
Academic Appointment
- Professor and Vice Chair, Cell Biology, Emory University
Education
Degrees
- PhD from Catholic University
- MD from Catholic University
Research
Focus
- Our laboratory studies AP-3 and BLOC-1-dependent trafficking mechanisms. These mechanisms target synaptic vesicle membrane proteins from endosomes to the synapse. We postulate that the AP-3-BLOC-1 pathway contributes to the pathogenesis of schizophrenia. Genetics studies have identified the gene encoding dysbindin (DTNBP1), a BLOC-1 subunit, as a top-ranking disease susceptibility gene.
Publications
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A primer on copper biology in the brain.
Neurobiol Dis Volume: 212 Page(s): 106974
01/01/2025 Authors: Lane AR; Roberts BR; Fahrni CJ; Faundez V -
Ethanol exposure during differentiation of human induced pluripotent stem cells reduces cardiomyocyte generation and alters metabolism.
Life Sci Volume: 364 Page(s): 123434
03/01/2025 Authors: Man K; Fu L; Lane A; Harris F; Reid O; Armand LC; Forghani P; Wu R; Faundez V; Brown LA -
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Mol Biol Cell Volume: 36 Page(s): ar33
03/01/2025 Authors: Lane AR; Scher NE; Bhattacharjee S; Zlatic SA; Roberts AM; Gokhale A; Singleton KS; Duong DM; McKenna M; Liu WL -
Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation.
bioRxiv
02/20/2025 Authors: Gokhale A; Mendez-Vazquez H; Sampson MM; Moctezuma FGR; Harbuzariu A; Sing A; Zlatic SA; Roberts AM; Prajapati M; Roberts BR -
The 2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors.
Mol Pharmacol Volume: 107 Page(s): 100005
01/01/2025 Authors: Chronis IB; Vistein R; Gokhale A; Faundez V; Puthenveedu MA -
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
11/18/2024 Authors: Lane AR; Scher NE; Bhattacharjee S; Zlatic SA; Roberts AM; Gokhale A; Singleton KS; Duong DM; McKenna M; Liu WL -
The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart.
Commun Biol Volume: 7 Page(s): 1422
10/31/2024 Authors: Ohanele C; Peoples JN; Karlstaedt A; Geiger JT; Gayle AD; Ghazal N; Sohani F; Brown ME; Davis ME; Porter GA -
The beta 2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors.
Mol Pharmacol
10/24/2024 Authors: Chronis IB; Vistein R; Gokhale A; Faundez V; Puthenveedu MA -
Proximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia.
Mol Cell Proteomics Volume: 23 Page(s): 100809
08/01/2024 Authors: Bowen CA; Nguyen HM; Lin Y; Bagchi P; Natu A; Espinosa-Garcia C; Werner E; Kumari R; Brandelli AD; Kumar P -
Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart.
bioRxiv
05/13/2024 Authors: Ohanele C; Peoples JN; Karlstaedt A; Geiger JT; Gayle AD; Ghazal N; Sohani F; Brown ME; Davis ME; Porter GA