Publications

• Variant mutation G215C in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation.
  PLoS Biol Volume: 23 Page(s): e3003115
  04/01/2025 Authors: Kubinski HC; Despres HW; Johnson BA; Schmidt MM; Jaffrani SA; Turner AH; Fanuele CD; Mills MG; Lokugamage KG; Dumas CM
• The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2.
  bioRxiv
  03/11/2025 Authors: Morgan AL; Vu MN; Zhou Y; Lokugamage KG; Meyers WM; Alvarado RE; Ahearn Y; Estes LK; Plante JA; Johnson BA
• Pellino-1, a therapeutic target for control of SARS-CoV-2 infection and disease severity.
  Antiviral Res Volume: 233 Page(s): 106059
  01/01/2025 Authors: Wang B; Xia H; Peng B-H; Choi E-J; Tian B; Xie X; Makino S; Bao X; Shi P-Y; Menachery V
• Rapid-response RNA-fluorescence in situ hybridization (FISH) assay platform for coronavirus antiviral high-throughput screening.
  SLAS Discov Volume: 29 Page(s): 100189
  12/01/2024 Authors: Chan R; Mugisha CS; Chuenchob V; Moquin SA; Manjunatha UH; Jarrousse N; Menachery VD; Xie X; Flannery EL; Eastman RT
• TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication.
  Nat Commun Volume: 15 Page(s): 10438
  11/30/2024 Authors: Gonzalez-Orozco M; Tseng H-C; Hage A; Xia H; Behera P; Afreen K; Peaflor-Tellez Y; Giraldo MI; Huante M; Puebla-Clark L
• SARS-CoV-2 EndoU-ribonuclease regulates RNA recombination and impacts viral fitness.
  bioRxiv
  11/13/2024 Authors: Zhou Y; Ahearn YP; Lokugamage KG; Alvarado RE; Estes LK; Meyers WM; McLeland AM; Morgan AL; Murray JT; Walker DH
• Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection.
  bioRxiv
  08/10/2024 Authors: Moore KM; Foster SL; Kar M; Floyd KA; Elrod EJ; Williams ME; Velden JV; Ellis M; Malik A; Wali B
• TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication.
  bioRxiv
  06/17/2024 Authors: Gonzalez-Orozco M; Tseng H-C; Hage A; Xia H; Behera P; Afreen K; Peaflor-Tellez Y; Giraldo MI; Huante M; Puebla-Clark L
• Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans.
  Virus Res Volume: 344 Page(s): 199357
  06/01/2024 Authors: Schfer A; Gralinski LE; Leist SR; Hampton BK; Mooney MA; Jensen KL; Graham RL; Agnihothram S; Jeng S; Chamberlin S
• A compendium of multi-omics data illuminating host responses to lethal human virus infections.
  Sci Data Volume: 11 Page(s): 328
  04/02/2024 Authors: Eisfeld AJ; Anderson LN; Fan S; Walters KB; Halfmann PJ; Westhoff Smith D; Thackray LB; Tan Q; Sims AC; Menachery VD
• Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
  Cell Rep Volume: 43 Page(s): 113965
  03/26/2024 Authors: Yang Z; Johnson BA; Meliopoulos VA; Ju X; Zhang P; Hughes MP; Wu J; Koreski KP; Clary JE; Chang T-C
• Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation.
  bioRxiv
  03/11/2024 Authors: Kubinski HC; Despres HW; Johnson BA; Schmidt MM; Jaffrani SA; Mills MG; Lokugamage K; Dumas CM; Shirley DJ; Estes LK
• The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions.
  EMBO Rep Volume: 25 Page(s): 902 - 926
  02/01/2024 Authors: Garvanska DH; Alvarado RE; Mundt FO; Lindqvist R; Duel JK; Coscia F; Nilsson E; Lokugamage K; Johnson BA; Plante JA
• Coronavirus 2'-O-methyltransferase: A promising therapeutic target.
  Virus Res Volume: 336 Page(s): 199211
  10/15/2023 Authors: Schindewolf C; Menachery VD
• SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection.
  bioRxiv
  09/01/2023 Authors: Garvanska DH; Alvarado RE; Mundt FO; Nilsson E; Duel JK; Coscia F; Lindqvist R; Lokugamage K; Johnson BA; Plante JA
• Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection.
  bioRxiv
  07/10/2023 Authors: Vu MN; Alvarado RE; Morris DR; Lokugamage KG; Zhou Y; Morgan AL; Estes LK; McLeland AM; Schindewolf C; Plante JA
• Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
  bioRxiv
  06/30/2023 Authors: Yang Z; Johnson BA; Meliopoulos VA; Ju X; Zhang P; Hughes MP; Wu J; Koreski KP; Chang T-C; Wu G
• SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection.
  Microbiol Spectr Volume: 11 Page(s): e0037823
  06/15/2023 Authors: Qu Y; Haas de Mello A; Morris DR; Jones-Hall YL; Ivanciuc T; Sattler RA; Paessler S; Menachery VD; Garofalo RP; Casola A
• The impact of RSV/SARS-CoV-2 co-infection on clinical disease and viral replication: insights from a BALB/c mouse model.
  bioRxiv
  05/24/2023 Authors: Morris DR; Qu Y; Thomason KS; de Mello AH; Preble R; Menachery VD; Casola A; Garofalo RP
• SARS-CoV-2 Uses Nonstructural Protein 16 To Evade Restriction by IFIT1 and IFIT3.
  J Virol Volume: 97 Page(s): e0153222
  02/28/2023 Authors: Schindewolf C; Lokugamage K; Vu MN; Johnson BA; Scharton D; Plante JA; Kalveram B; Crocquet-Valdes PA; Sotcheff S; Jaworski E
• Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
  ACS Cent Sci Volume: 9 Page(s): 217 - 227
  02/22/2023 Authors: Hou N; Shuai L; Zhang L; Xie X; Tang K; Zhu Y; Yu Y; Zhang W; Tan Q; Zhong G
• Publisher Correction: A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions.
  Nat Commun Volume: 13 Page(s): 6060
  10/13/2022 Authors: Liu Y; Zhang X; Liu J; Xia H; Zou J; Muruato AE; Periasamy S; Kurhade C; Plante JA; Bopp NE
• SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3.
  bioRxiv
  09/26/2022 Authors: Schindewolf C; Lokugamage K; Vu MN; Johnson BA; Scharton D; Plante JA; Kalveram B; Crocquet-Valdes PA; Sotcheff S; Jaworski E
• Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
  Nat Commun Volume: 13 Page(s): 5552
  09/22/2022 Authors: Ku Z; Xie X; Lin J; Gao P; Wu B; El Sahili A; Su H; Liu Y; Ye X; Tan EY
• Vaccination Decreases the Infectious Viral Load of Delta Variant SARS-CoV-2 in Asymptomatic Patients.
  Viruses Volume: 14
  09/18/2022 Authors: Plante JA; Machado RRG; Mitchell BM; Shinde DP; Walker J; Scharton D; McConnell A; Saada N; Liu J; Khan B
• QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis.
  Proc Natl Acad Sci U S A Volume: 119 Page(s): e2205690119
  08/09/2022 Authors: Vu MN; Lokugamage KG; Plante JA; Scharton D; Bailey AO; Sotcheff S; Swetnam DM; Johnson BA; Schindewolf C; Alvarado RE
• A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions.
  Nat Commun Volume: 13 Page(s): 4337
  07/27/2022 Authors: Liu Y; Zhang X; Liu J; Xia H; Zou J; Muruato AE; Periasamy S; Kurhade C; Plante JA; Bopp NE
• Erratum for Vanderheiden et al., "CCR2 Signaling Restricts SARS-CoV-2 Infection".
  mBio Volume: 13 Page(s): e0025922
  06/28/2022 Authors: Vanderheiden A; Thomas J; Soung AL; Davis-Gardner ME; Floyd K; Jin F; Cowan DA; Pellegrini K; Creanga A; Pegu A
• Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
  PLoS Pathog Volume: 18 Page(s): e1010627
  06/01/2022 Authors: Johnson BA; Zhou Y; Lokugamage KG; Vu MN; Bopp N; Crocquet-Valdes PA; Kalveram B; Schindewolf C; Liu Y; Scharton D
• LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.
  Cell Rep Volume: 39 Page(s): 110812
  05/17/2022 Authors: Westendorf K; entelis S; Wang L; Foster D; Vaillancourt P; Wiggin M; Lovett E; van der Lee R; Hendle J; Pustilnik A
• Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.
  Cell Rep Volume: 39 Page(s): 110829
  05/17/2022 Authors: Liu Y; Liu J; Johnson BA; Xia H; Ku Z; Schindewolf C; Widen SG; An Z; Weaver SC; Menachery VD
• Defining the risk of SARS-CoV-2 variants on immune protection.
  Nature Volume: 605 Page(s): 640 - 652
  05/01/2022 Authors: DeGrace MM; Ghedin E; Frieman MB; Krammer F; Grifoni A; Alisoltani A; Alter G; Amara RR; Baric RS; Barouch DH
• Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
  bioRxiv
  03/28/2022 Authors: Johnson BA; Zhou Y; Lokugamage KG; Vu MN; Bopp N; Crocquet-Valdes PA; Kalveram B; Schindewolf C; Liu Y; Scharton D
• Analytical characterization of the SARS-CoV-2 EURM-017 reference material.
  Clin Biochem Volume: 101 Page(s): 19 - 25
  03/01/2022 Authors: Freeman J; Olson K; Conklin J; Shalhoub V; Johnson BA; Bopp NE; Fernandez D; Menachery VD; Aguilar PV
• A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions.
  bioRxiv
  02/15/2022 Authors: Liu Y; Zhang X; Liu J; Xia H; Zou J; Muruato AE; Periasamy S; Plante JA; Bopp NE; Kurhade C
• Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
  bioRxiv
  02/01/2022 Authors: Ku Z; Xie X; Lin J; Gao P; El Sahili A; Su H; Liu Y; Ye X; Li X; Fan X
• The N501Y spike substitution enhances SARS-CoV-2 infection and transmission.
  Nature Volume: 602 Page(s): 294 - 299
  02/01/2022 Authors: Liu Y; Liu J; Plante KS; Plante JA; Xie X; Zhang X; Ku Z; An Z; Scharton D; Schindewolf C
• A new tool to probe SARS-CoV-2 variants.
  Science Volume: 374 Page(s): 1557 - 1558
  12/24/2021 Authors: Johnson BA; Menachery VD
• CCR2 Signaling Restricts SARS-CoV-2 Infection.
  mBio Volume: 12 Page(s): e0274921
  12/21/2021 Authors: Vanderheiden A; Thomas J; Soung AL; Davis-Gardner ME; Floyd K; Jin F; Cowan DA; Pellegrini K; Shi P-Y; Grakoui A
• Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
  PLoS Biol Volume: 19 Page(s): e3001284
  11/01/2021 Authors: Muruato A; Vu MN; Johnson BA; Davis-Gardner ME; Vanderheiden A; Lokugamage K; Schindewolf C; Crocquet-Valdes PA; Langsjoen RM; Plante JA
• Coagulation and wound repair during COVID-19.
  J Heart Lung Transplant Volume: 40 Page(s): 1076 - 1081
  10/01/2021 Authors: Menachery VD; Gralinski LE
• Catch Me if You Can: Superspreading of COVID-19.
  Trends Microbiol Volume: 29 Page(s): 919 - 929
  10/01/2021 Authors: Lakdawala SS; Menachery VD
• Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants.
  Elife Volume: 10
  09/28/2021 Authors: Jaworski E; Langsjoen RM; Mitchell B; Judy B; Newman P; Plante JA; Plante KS; Miller AL; Zhou Y; Swetnam D
• Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants.
  Science Volume: 373 Page(s): 1372 - 1377
  09/17/2021 Authors: Pegu A; O'Connell SE; Schmidt SD; O'Dell S; Talana CA; Lai L; Albert J; Anderson E; Bennett H; Corbett KS
• Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.
  bioRxiv
  09/05/2021 Authors: Liu Y; Liu J; Johnson BA; Xia H; Ku Z; Schindewolf C; Widen SG; An Z; Weaver SC; Menachery VD
• Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants.
  bioRxiv
  09/01/2021 Authors: Jaworski E; Langsjoen RM; Mitchell B; Judy B; Newman P; Plante JA; Plante KS; Miller AL; Zhou Y; Swetnam D
• Endomembrane targeting of human OAS1 p46 augments antiviral activity.
  Elife Volume: 10
  08/03/2021 Authors: Soveg FW; Schwerk J; Gokhale NS; Cerosaletti K; Smith JR; Pairo-Castineira E; Kell AM; Forero A; Zaver SA; Esser-Nobis K
• Binding and entering: COVID finds a new home.
  PLoS Pathog Volume: 17 Page(s): e1009857
  08/01/2021 Authors: Vu MN; Menachery VD
• Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity.
  J Immunol Volume: 207 Page(s): 376 - 379
  07/15/2021 Authors: Matchett WE; Joag V; Stolley JM; Shepherd FK; Quarnstrom CF; Mickelson CK; Wijeyesinghe S; Soerens AG; Becker S; Thiede JM
• Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
  Nat Commun Volume: 12 Page(s): 4177
  07/01/2021 Authors: Ku Z; Xie X; Davidson E; Ye X; Su H; Menachery VD; Li Y; Yuan Z; Zhang X; Muruato AE
• Author Correction: Spike mutation D614G alters SARS-CoV-2 fitness.
  Nature Volume: 595 Page(s): E1
  07/01/2021 Authors: Plante JA; Liu Y; Liu J; Xia H; Johnson BA; Lokugamage KG; Zhang X; Muruato AE; Zou J; Fontes-Garfias CR
• Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants.
  Nature Volume: 595 Page(s): 718 - 723
  07/01/2021 Authors: Ku Z; Xie X; Hinton PR; Liu X; Ye X; Muruato AE; Ng DC; Biswas S; Zou J; Liu Y
• Author Correction: A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation.
  Nat Commun Volume: 12 Page(s): 4000
  06/22/2021 Authors: Muruato AE; Fontes-Garfias CR; Ren P; Garcia-Blanco MA; Menachery VD; Xie X; Shi P-Y
• Author Correction: A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.
  Nat Commun Volume: 12 Page(s): 3984
  06/21/2021 Authors: Xie X; Muruato AE; Zhang X; Lokugamage KG; Fontes-Garfias CR; Zou J; Liu J; Ren P; Balakrishnan M; Cihlar T
• SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.
  Nat Commun Volume: 12 Page(s): 3587
  06/11/2021 Authors: Routhu NK; Cheedarla N; Bollimpelli VS; Gangadhara S; Edara VV; Lai L; Sahoo A; Shiferaw A; Styles TM; Floyd K
• Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain.
  J Immunol Volume: 206 Page(s): 2605 - 2613
  06/01/2021 Authors: Mantus G; Nyhoff LE; Kauffman RC; Edara VV; Lai L; Floyd K; Shi P-Y; Menachery VD; Edupuganti S; Scherer EM
• Hypergraph models of biological networks to identify genes critical to pathogenic viral response.
  BMC Bioinformatics Volume: 22 Page(s): 287
  05/29/2021 Authors: Feng S; Heath E; Jefferson B; Joslyn C; Kvinge H; Mitchell HD; Praggastis B; Eisfeld AJ; Sims AC; Thackray LB
• Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
  bioRxiv
  05/04/2021 Authors: Muruato A; Vu MN; Johnson BA; Davis-Gardner ME; Vanderheiden A; Lokugmage K; Schindewolf C; Crocquet-Valdes PA; Langsjoen RM; Plante JA
• CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection.
  bioRxiv
  05/04/2021 Authors: Vanderheiden A; Thomas J; Soung AL; Davis-Gardner ME; Floyd K; Jin F; Cowan DA; Pellegrini K; Creanga A; Pegu A
• TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.
  PLoS Pathog Volume: 17 Page(s): e1009599
  05/01/2021 Authors: Trimarco JD; Heaton BE; Chaparian RR; Burke KN; Binder RA; Gray GC; Smith CM; Menachery VD; Heaton NS
• Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity.
  bioRxiv
  04/27/2021 Authors: Matchett WE; Joag V; Stolley JM; Shepherd FK; Quarnstrom CF; Mickelson CK; Wijeyesinghe S; Soerens AG; Becker S; Thiede JM
• Immune Profiling to Determine Early Disease Trajectories Associated With Coronavirus Disease 2019 Mortality Rate: A Substudy from the ACTT-1 Trial.
  J Infect Dis Volume: 223 Page(s): 1339 - 1344
  04/23/2021 Authors: Thiede JM; Gress AR; Libby SD; Ronayne CE; Matchett WE; Noren B; Billings JL; Menachery VD; Langlois RA; Kline S
• A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence.
  Cell Volume: 184 Page(s): 2229 - 2238.e13
  04/15/2021 Authors: Zhang X; Liu Y; Liu J; Bailey AL; Plante KS; Plante JA; Zou J; Xia H; Bopp NE; Aguilar PV
• The variant gambit: COVID-19's next move.
  Cell Host Microbe Volume: 29 Page(s): 508 - 515
  04/14/2021 Authors: Plante JA; Mitchell BM; Plante KS; Debbink K; Weaver SC; Menachery VD
• Spike mutation D614G alters SARS-CoV-2 fitness.
  Nature Volume: 592 Page(s): 116 - 121
  04/01/2021 Authors: Plante JA; Liu Y; Liu J; Xia H; Johnson BA; Lokugamage KG; Zhang X; Muruato AE; Zou J; Fontes-Garfias CR
• Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
  Nat Med Volume: 27 Page(s): 620 - 621
  04/01/2021 Authors: Xie X; Liu Y; Liu J; Zhang X; Zou J; Fontes-Garfias CR; Xia H; Swanson KA; Cutler M; Cooper D
• The N501Y spike substitution enhances SARS-CoV-2 transmission.
  bioRxiv
  03/09/2021 Authors: Liu Y; Liu J; Plante KS; Plante JA; Xie X; Zhang X; Ku Z; An Z; Scharton D; Schindewolf C
• A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
  Immunity Volume: 54 Page(s): 542 - 556.e9
  03/09/2021 Authors: Routhu NK; Cheedarla N; Gangadhara S; Bollimpelli VS; Boddapati AK; Shiferaw A; Rahman SA; Sahoo A; Edara VV; Lai L
• Engineering SARS-CoV-2 using a reverse genetic system.
  Nat Protoc Volume: 16 Page(s): 1761 - 1784
  03/01/2021 Authors: Xie X; Lokugamage KG; Zhang X; Vu MN; Muruato AE; Menachery VD; Shi P-Y
• Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
  Nature Volume: 591 Page(s): 293 - 299
  03/01/2021 Authors: Johnson BA; Xie X; Bailey AL; Kalveram B; Lokugamage KG; Muruato A; Zou J; Zhang X; Juelich T; Smith JK
• Infection and mRNA-1273 vaccine antibodies neutralize SARS-CoV-2 UK variant.
  medRxiv
  02/05/2021 Authors: Edara VV; Floyd K; Lai L; Gardner M; Hudson W; Piantadosi A; Waggoner JJ; Babiker A; Ahmed R; Xie X
• Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera.
  bioRxiv
  01/27/2021 Authors: Xie X; Liu Y; Liu J; Zhang X; Zou J; Fontes-Garfias CR; Xia H; Swanson KA; Cutler M; Cooper D
• Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
  Nat Commun Volume: 12 Page(s): 469
  01/20/2021 Authors: Ku Z; Xie X; Davidson E; Ye X; Su H; Menachery VD; Li Y; Yuan Z; Zhang X; Muruato AE
• Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera.
  Res Sq
  01/13/2021 Authors: Shi P-Y; Xie X; Zou J; Fontes-Garfias C; Xia H; Swanson K; Cutler M; Cooper D; Menachery V; Weaver S
• Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera.
  bioRxiv
  01/07/2021 Authors: Xie X; Zou J; Fontes-Garfias CR; Xia H; Swanson KA; Cutler M; Cooper D; Menachery VD; Weaver S; Dormitzer PR
• Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium.
  PLoS Pathog Volume: 17 Page(s): e1009292
  01/01/2021 Authors: Fiege JK; Thiede JM; Nanda HA; Matchett WE; Moore PJ; Montanari NR; Thielen BK; Daniel J; Stanley E; Hunter RC
• Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.
  PLoS Pathog Volume: 17 Page(s): e1009287
  01/01/2021 Authors: Graham JB; Swarts JL; Leist SR; Schfer A; Menachery VD; Gralinski LE; Jeng S; Miller DR; Mooney MA; McWeeney SK
• SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with nonsevere disease.
  Transfusion Volume: 61 Page(s): 17 - 23
  01/01/2021 Authors: Gniadek TJ; Thiede JM; Matchett WE; Gress AR; Pape KA; Fiege JK; Jenkins MK; Menachery VD; Langlois RA; Bold TD
• Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies.
  Curr Protoc Immunol Volume: 131 Page(s): e116
  12/01/2020 Authors: Vanderheiden A; Edara VV; Floyd K; Kauffman RC; Mantus G; Anderson E; Rouphael N; Edupuganti S; Shi P-Y; Menachery VD
• Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C).
  Pediatrics Volume: 146
  12/01/2020 Authors: Rostad CA; Chahroudi A; Mantus G; Lapp SA; Teherani M; Macoy L; Tarquinio KM; Basu RK; Kao C; Linam WM
• Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV.
  J Virol Volume: 94
  11/09/2020 Authors: Lokugamage KG; Hage A; de Vries M; Valero-Jimenez AM; Schindewolf C; Dittmann M; Rajsbaum R; Menachery VD
• Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium.
  bioRxiv
  10/19/2020 Authors: Fiege JK; Thiede JM; Nanda H; Matchett WE; Moore PJ; Montanari NR; Thielen BK; Daniel J; Stanley E; Hunter RC
• A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.
  Nat Commun Volume: 11 Page(s): 5214
  10/15/2020 Authors: Xie X; Muruato AE; Zhang X; Lokugamage KG; Fontes-Garfias CR; Zou J; Liu J; Ren P; Balakrishnan M; Cihlar T
• Evasion of Type I Interferon by SARS-CoV-2.
  Cell Rep Volume: 33 Page(s): 108234
  10/06/2020 Authors: Xia H; Cao Z; Xie X; Zhang X; Chen JY-C; Wang H; Menachery VD; Rajsbaum R; Shi P-Y
• Topoisomerase III- is required for efficient replication of positive-sense RNA viruses.
  Antiviral Res Volume: 182 Page(s): 104874
  10/01/2020 Authors: Prasanth KR; Hirano M; Fagg WS; McAnarney ET; Shan C; Xie X; Hage A; Pietzsch CA; Bukreyev A; Rajsbaum R
• Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection.
  bioRxiv
  09/21/2020 Authors: Graham JB; Swarts JL; Leist SR; Schfer A; Menachery VD; Gralinski LE; Jeng S; Miller DR; Mooney MA; McWeeney SK
• Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures.
  J Virol Volume: 94
  09/15/2020 Authors: Vanderheiden A; Ralfs P; Chirkova T; Upadhyay AA; Zimmerman MG; Bedoya S; Aoued H; Tharp GM; Pellegrini KL; Manfredi C
• Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility.
  Res Sq
  09/10/2020 Authors: Shi P-Y; Plante J; Liu Y; Liu J; Xia H; Johnson B; Lokugamage K; Zhang X; Muruato A; Zou J
• Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility.
  bioRxiv
  09/02/2020 Authors: Plante JA; Liu Y; Liu J; Xia H; Johnson BA; Lokugamage KG; Zhang X; Muruato AE; Zou J; Fontes-Garfias CR
• Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis.
  bioRxiv
  08/26/2020 Authors: Johnson BA; Xie X; Kalveram B; Lokugamage KG; Muruato A; Zou J; Zhang X; Juelich T; Smith JK; Zhang L
• A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation.
  Nat Commun Volume: 11 Page(s): 4059
  08/13/2020 Authors: Muruato AE; Fontes-Garfias CR; Ren P; Garcia-Blanco MA; Menachery VD; Xie X; Shi P-Y
• Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.
  bioRxiv
  07/13/2020 Authors: Lokugamage KG; Hage A; de Vries M; Valero-Jimenez AM; Schindewolf C; Dittmann M; Rajsbaum R; Menachery VD
• Author Correction: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
  Nat Med Volume: 26 Page(s): 1146
  07/01/2020 Authors: Menachery VD; Yount BL; Debbink K; Agnihothram S; Gralinski LE; Plante JA; Graham RL; Scobey T; Ge X-Y; Donaldson EF
• Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients.
  Cell Rep Med Volume: 1 Page(s): 100040
  06/23/2020 Authors: Suthar MS; Zimmerman MG; Kauffman RC; Mantus G; Linderman SL; Hudson WH; Vanderheiden A; Nyhoff L; Davis CW; Adekunle O
• Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States.
  Emerg Infect Dis Volume: 26 Page(s): 1266 - 1273
  06/01/2020 Authors: Harcourt J; Tamin A; Lu X; Kamili S; Sakthivel SK; Murray J; Queen K; Tao Y; Paden CR; Zhang J
• The search for a COVID-19 animal model.
  Science Volume: 368 Page(s): 942 - 943
  05/29/2020 Authors: Lakdawala SS; Menachery VD
• A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation.
  bioRxiv
  05/22/2020 Authors: Muruato AE; Fontes-Garfias CR; Ren P; Garcia-Blanco MA; Menachery VD; Xie X; Shi P-Y
• Novel Ionophores Active against La Crosse Virus Identified through Rapid Antiviral Screening.
  Antimicrob Agents Chemother Volume: 64
  05/21/2020 Authors: Sandler ZJ; Firpo MR; Omoba OS; Vu MN; Menachery VD; Mounce BC
• An Infectious cDNA Clone of SARS-CoV-2.
  Cell Host Microbe Volume: 27 Page(s): 841 - 848.e3
  05/13/2020 Authors: Xie X; Muruato A; Lokugamage KG; Narayanan K; Zhang X; Zou J; Liu J; Schindewolf C; Bopp NE; Aguilar PV
• Rapid generation of neutralizing antibody responses in COVID-19 patients.
  medRxiv
  05/08/2020 Authors: Suthar MS; Zimmerman M; Kauffman R; Mantus G; Linderman S; Vanderheiden A; Nyhoff L; Davis C; Adekunle S; Affer M
• Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross.
  Cell Rep Volume: 31 Page(s): 107587
  04/28/2020 Authors: Noll KE; Whitmore AC; West A; McCarthy MK; Morrison CR; Plante KS; Hampton BK; Kollmus H; Pilzner C; Leist SR
• Topoisomerase III- is required for efficient replication of positive-sense RNA viruses.
  bioRxiv
  03/27/2020 Authors: Prasanth KR; Hirano M; Fagg WS; McAnarney ET; Shan C; Xie X; Hage A; Pietzsch CA; Bukreyev A; Rajsbaum R
• Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient.
  bioRxiv
  03/07/2020 Authors: Harcourt J; Tamin A; Lu X; Kamili S; Sakthivel SK; Murray J; Queen K; Tao Y; Paden CR; Zhang J
• Immune Predictors of Mortality After Ribonucleic Acid Virus Infection.
  J Infect Dis Volume: 221 Page(s): 882 - 889
  03/02/2020 Authors: Graham JB; Swarts JL; Menachery VD; Gralinski LE; Schfer A; Plante KS; Morrison CR; Voss KM; Green R; Choonoo G
• Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection.
  J Virol Volume: 94
  02/14/2020 Authors: Menachery VD; Dinnon KH; Yount BL; McAnarney ET; Gralinski LE; Hale A; Graham RL; Scobey T; Anthony SJ; Wang L
• Return of the Coronavirus: 2019-nCoV.
  Viruses Volume: 12
  01/24/2020 Authors: Gralinski LE; Menachery VD
• Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity.
  J Virol Volume: 93
  11/15/2019 Authors: Johnson BA; Hage A; Kalveram B; Mears M; Plante JA; Rodriguez SE; Ding Z; Luo X; Bente D; Bradrick SS
• Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity.
  PLoS Negl Trop Dis Volume: 13 Page(s): e0007212
  03/01/2019 Authors: Dinnon Iii KH; Gallichotte EN; Fritch EJ; Menachery VD; Baric RS
• Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism.
  Viruses Volume: 11
  01/17/2019 Authors: Schindewolf C; Menachery VD
• SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).
  Viruses Volume: 10
  12/19/2018 Authors: van Doremalen N; Schfer A; Menachery VD; Letko M; Bushmaker T; Fischer RJ; Figueroa DM; Hanley PW; Saturday G; Baric RS
• Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.
  mBio Volume: 9
  10/09/2018 Authors: Gralinski LE; Sheahan TP; Morrison TE; Menachery VD; Jensen K; Leist SR; Whitmore A; Heise MT; Baric RS
• Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.
  J Virol Volume: 92
  09/01/2018 Authors: Menachery VD; Gralinski LE; Mitchell HD; Dinnon KH; Leist SR; Yount BL; McAnarney ET; Graham RL; Waters KM; Baric RS
• CC002/Unc females are mouse models of exercise-induced paradoxical fat response.
  Physiol Rep Volume: 6 Page(s): e13716
  06/01/2018 Authors: McMullan RC; Ferris MT; Bell TA; Menachery VD; Baric RS; Hua K; Pomp D; Smith-Ryan AE; de Villena FP-M
• Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform.
  J Virol Volume: 92
  06/01/2018 Authors: Agnihothram S; Menachery VD; Yount BL; Lindesmith LC; Scobey T; Whitmore A; Schfer A; Heise MT; Baric RS
• Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses.
  Virology Volume: 517 Page(s): 30 - 37
  04/01/2018 Authors: Johnson BA; Graham RL; Menachery VD
• MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.
  Proc Natl Acad Sci U S A Volume: 115 Page(s): E1012 - E1021
  01/30/2018 Authors: Menachery VD; Schfer A; Burnum-Johnson KE; Mitchell HD; Eisfeld AJ; Walters KB; Nicora CD; Purvine SO; Casey CP; Monroe ME
• CD-loop Extension in Zika Virus Envelope Protein Key for Stability and Pathogenesis.
  J Infect Dis Volume: 216 Page(s): 1196 - 1204
  12/05/2017 Authors: Gallichotte EN; Dinnon KH; Lim X-N; Ng T-S; Lim EXY; Menachery VD; Lok S-M; Baric RS
• MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis.
  mBio Volume: 8
  08/22/2017 Authors: Menachery VD; Mitchell HD; Cockrell AS; Gralinski LE; Yount BL; Graham RL; McAnarney ET; Douglas MG; Scobey T; Beall A
• Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.
  Sci Transl Med Volume: 9
  06/28/2017 Authors: Sheahan TP; Sims AC; Graham RL; Menachery VD; Gralinski LE; Case JB; Leist SR; Pyrc K; Feng JY; Trantcheva I
• Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice.
  G3 (Bethesda) Volume: 7 Page(s): 1653 - 1663
  06/07/2017 Authors: Gralinski LE; Menachery VD; Morgan AP; Totura AL; Beall A; Kocher J; Plante J; Harrison-Shostak DC; Schfer A; Pardo-Manuel de Villena F
• Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus.
  mBio Volume: 8
  04/04/2017 Authors: Anthony SJ; Gilardi K; Menachery VD; Goldstein T; Ssebide B; Mbabazi R; Navarrete-Macias I; Liang E; Wells H; Hicks A
• Jumping species-a mechanism for coronavirus persistence and survival.
  Curr Opin Virol Volume: 23 Page(s): 1 - 7
  04/01/2017 Authors: Menachery VD; Graham RL; Baric RS
• Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone.
  mSphere Volume: 2
  01/01/2017 Authors: Gallichotte EN; Menachery VD; Yount BL; Widman DG; Dinnon KH; Hartman S; de Silva AM; Baric RS
• Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.
  mSphere Volume: 2
  01/01/2017 Authors: Menachery VD; Gralinski LE; Mitchell HD; Dinnon KH; Leist SR; Yount BL; Graham RL; McAnarney ET; Stratton KG; Cockrell AS
• Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
  Nat Med Volume: 22 Page(s): 446
  04/01/2016 Authors: Menachery VD; Yount BL; Debbink K; Agnihothram S; Gralinski LE; Plante JA; Graham RL; Scobey T; Ge X-Y; Donaldson EF
• SARS-like WIV1-CoV poised for human emergence.
  Proc Natl Acad Sci U S A Volume: 113 Page(s): 3048 - 3053
  03/15/2016 Authors: Menachery VD; Yount BL; Sims AC; Debbink K; Agnihothram SS; Gralinski LE; Graham RL; Scobey T; Plante JA; Royal SR
• A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
  Nat Med Volume: 21 Page(s): 1508 - 1513
  12/01/2015 Authors: Menachery VD; Yount BL; Debbink K; Agnihothram S; Gralinski LE; Plante JA; Graham RL; Scobey T; Ge X-Y; Donaldson EF
• Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.
  PLoS Genet Volume: 11 Page(s): e1005504
  10/01/2015 Authors: Gralinski LE; Ferris MT; Aylor DL; Whitmore AC; Green R; Frieman MB; Deming D; Menachery VD; Miller DR; Buus RJ
• MERS Vaccine Candidate Offers Promise, but Questions Remain.
  EBioMedicine Volume: 2 Page(s): 1292 - 1293
  10/01/2015 Authors: Menachery VD
• New Metrics for Evaluating Viral Respiratory Pathogenesis.
  PLoS One Volume: 10 Page(s): e0131451
  01/01/2015 Authors: Menachery VD; Gralinski LE; Baric RS; Ferris MT
• Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
  BMC Genomics Volume: 15 Page(s): 1161
  12/22/2014 Authors: Selinger C; Tisoncik-Go J; Menachery VD; Agnihothram S; Law GL; Chang J; Kelly SM; Sova P; Baric RS; Katze MG
• Coronavirus non-structural protein 16: evasion, attenuation, and possible treatments.
  Virus Res Volume: 194 Page(s): 191 - 199
  12/19/2014 Authors: Menachery VD; Debbink K; Baric RS
• Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.
  mBio Volume: 5 Page(s): e01174 - e01114
  05/20/2014 Authors: Menachery VD; Eisfeld AJ; Schfer A; Josset L; Sims AC; Proll S; Fan S; Li C; Neumann G; Tilton SC
• Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.
  J Virol Volume: 88 Page(s): 4251 - 4264
  04/01/2014 Authors: Menachery VD; Yount BL; Josset L; Gralinski LE; Scobey T; Agnihothram S; Katze MG; Baric RS
• Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses.
  J Infect Dis Volume: 209 Page(s): 995 - 1006
  04/01/2014 Authors: Agnihothram S; Gopal R; Yount BL; Donaldson EF; Menachery VD; Graham RL; Scobey TD; Gralinski LE; Denison MR; Zambon M
• A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant.
  mBio Volume: 5 Page(s): e00047 - e00014
  03/25/2014 Authors: Agnihothram S; Yount BL; Donaldson EF; Huynh J; Menachery VD; Gralinski LE; Graham RL; Becker MM; Tomar S; Scobey TD
• A comprehensive collection of systems biology data characterizing the host response to viral infection.
  Sci Data Volume: 1 Page(s): 140033
  01/01/2014 Authors: Aevermann BD; Pickett BE; Kumar S; Klem EB; Agnihothram S; Askovich PS; Bankhead A; Bolles M; Carter V; Chang J
• Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.
  Proc Natl Acad Sci U S A Volume: 110 Page(s): 16157 - 16162
  10/01/2013 Authors: Scobey T; Yount BL; Sims AC; Donaldson EF; Agnihothram SS; Menachery VD; Graham RL; Swanstrom J; Bove PF; Kim JD
• Bugs in the system.
  Immunol Rev Volume: 255 Page(s): 256 - 274
  09/01/2013 Authors: Menachery VD; Baric RS
• Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury.
  mBio Volume: 4
  08/06/2013 Authors: Gralinski LE; Bankhead A; Jeng S; Menachery VD; Proll S; Belisle SE; Matzke M; Webb-Robertson B-JM; Luna ML; Shukla AK
• Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus.
  mBio Volume: 4 Page(s): e00165 - e00113
  04/30/2013 Authors: Josset L; Menachery VD; Gralinski LE; Agnihothram S; Sova P; Carter VS; Yount BL; Graham RL; Baric RS; Katze MG
• Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.
  J Virol Volume: 87 Page(s): 3885 - 3902
  04/01/2013 Authors: Sims AC; Tilton SC; Menachery VD; Gralinski LE; Schfer A; Matzke MM; Webb-Robertson B-JM; Chang J; Luna ML; Long CE
• Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff.
  J Virol Volume: 86 Page(s): 7692 - 7695
  07/01/2012 Authors: Pasieka TJ; Menachery VD; Rosato PC; Leib DA
• Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection.
  J Virol Volume: 84 Page(s): 9685 - 9694
  10/01/2010 Authors: Menachery VD; Pasieka TJ; Leib DA
• Control of herpes simplex virus replication is mediated through an interferon regulatory factor 3-dependent pathway.
  J Virol Volume: 83 Page(s): 12399 - 12406
  12/01/2009 Authors: Menachery VD; Leib DA
• Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state.
  J Virol Volume: 82 Page(s): 5527 - 5535
  06/01/2008 Authors: Pasieka TJ; Lu B; Crosby SD; Wylie KM; Morrison LA; Alexander DE; Menachery VD; Leib DA