Una O'Doherty

Department of Pathology and Laboratory Medicine
Acting Professor

Emory University
Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine
615 Michael Street

Overview

https://www.odohertylab.com/

Academic Appointment

Acting Professor of Pathology and Laboratory Medicine, Emory University School of Medicine

Education

Degrees

Ph.D. (Immunology) from Rockefeller University
M.D. from Cornell University Medical College
B.S. (BioChemistry) from Barnard College

Research

Focus

Blood cells in health and disease
My career revolves around the study of blood cells in health and disease. In HIV, we probe the role of antigen-naive T cells in HIV persistence, providing new targets for its eradication. In sickle cell disease, we probe the role of hemolysis in driving increased WBC turnover and leukemia risk.

Publications

Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis.
Blood Volume: 143 Page(s): 1049 - 1054
03/14/2024 Authors: Mack EA; Dougher MC; Ginda AM; Cahill C; Murter M; Schell K; Tanhehco YC; Bhoj VG; Fesnak AD; Siegel DL
Serotonin reduction in post-acute sequelae of viral infection.
Cell Volume: 186 Page(s): 4851 - 4867.e20
10/26/2023 Authors: Wong AC; Devason AS; Umana IC; Cox TO; Dohnalov L; Litichevskiy L; Perla J; Lundgren P; Etwebi Z; Izzo LT
Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.
AIDS Res Hum Retroviruses
06/19/2023 Authors: Sanders-Beer BE; Archin NM; Brumme ZL; Busch MP; Deleage C; O'Doherty U; Hughes SH; Jerome KR; Jones RB; Karn J
Highlights from the Inaugural HIV Reservoirs and Immune Control Conference, October 1st-4th 2023, Malahide Ireland.
Pathog Immun Volume: 8 Page(s): 161 - 169
01/01/2023 Authors: O'Doherty U; Martinez-Picado J; Sez-Cirin A
Machine Learning Bolsters Evidence That D1, Nef, and Tat Influence HIV Reservoir Dynamics.
Pathog Immun Volume: 8 Page(s): 37 - 58
01/01/2023 Authors: Cannon L; Fehrman S; Pinzone M; Weissman S; O'Doherty U
Rapid manufacturing of non-activated potent CAR T cells.
Nat Biomed Eng Volume: 6 Page(s): 118 - 128
02/01/2022 Authors: Ghassemi S; Durgin JS; Nunez-Cruz S; Patel J; Leferovich J; Pinzone M; Shen F; Cummins KD; Plesa G; Cantu VA
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking.
Clin Chem Volume: 68 Page(s): 230 - 239
12/30/2021 Authors: Chen H; Li Z; Feng S; Richard-Greenblatt M; Hutson E; Andrianus S; Glaser LJ; Rodino KG; Qian J; Jayaraman D
Naive infection predicts reservoir diversity and is a formidable hurdle to HIV eradication.
JCI Insight Volume: 6
08/23/2021 Authors: Pinzone MR; Weissman S; Pasternak AO; Zurakowski R; Migueles S; O'Doherty U
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Dynamics Tracking.
medRxiv
03/26/2021 Authors: Chen H; Li Z; Feng S; Wang A; Richard-Greenblatt M; Hutson E; Andrianus S; Glaser LJ; Rodino KG; Qian J
Persistence of an intact HIV reservoir in phenotypically naive T cells.
JCI Insight Volume: 5
10/15/2020 Authors: Venanzi Rullo E; Pinzone MR; Cannon L; Weissman S; Ceccarelli M; Zurakowski R; Nunnari G; O'Doherty U
Interferon- alters host glycosylation machinery during treated HIV infection.
EBioMedicine Volume: 59 Page(s): 102945
09/01/2020 Authors: Giron LB; Colomb F; Papasavvas E; Azzoni L; Yin X; Fair M; Anzurez A; Damra M; Mounzer K; Kostman JR
Next-Generation Sequencing in a Direct Model of HIV Infection Reveals Important Parallels to and Differences from In Vivo Reservoir Dynamics.
J Virol Volume: 94
04/16/2020 Authors: Pinzone MR; Bertuccio MP; VanBelzen DJ; Zurakowski R; O'Doherty U
Genetic Evidence That Naive T Cells Can Contribute Significantly to the Human Immunodeficiency Virus Intact Reservoir: Time to Re-evaluate Their Role.
Clin Infect Dis Volume: 69 Page(s): 2236 - 2237
11/27/2019 Authors: Venanzi Rullo E; Cannon L; Pinzone MR; Ceccarelli M; Nunnari G; O'Doherty U
Heavy metal protease takes a tiki torch to HIV assembly.
Nat Immunol Volume: 20 Page(s): 668 - 669
06/01/2019 Authors: O'Doherty U; Freed EO
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion.
Nat Commun Volume: 10 Page(s): 728
02/13/2019 Authors: Pinzone MR; VanBelzen DJ; Weissman S; Bertuccio MP; Cannon L; Venanzi-Rullo E; Migueles S; Jones RB; Mota T; Joseph SB
More efficient exchange of sickle red blood cells can be achieved by exchanging the densest red blood cells: An ex vivo proof of concept study.
Transfus Apher Sci Volume: 58 Page(s): 100 - 106
02/01/2019 Authors: Thibodeaux SR; Tanhehco YC; Irwin L; Jamensky L; Schell K; O'Doherty U
Quantitation of Integrated HIV Provirus by Pulsed-Field Gel Electrophoresis and Droplet Digital PCR.
J Clin Microbiol Volume: 56
12/01/2018 Authors: Lada SM; Huang K; VanBelzen DJ; Montaner LJ; O'Doherty U; Richman DD
HLA-C downregulation by HIV-1 adapts to host HLA genotype.
PLoS Pathog Volume: 14 Page(s): e1007257
09/01/2018 Authors: Bachtel ND; Umviligihozo G; Pickering S; Mota TM; Liang H; Del Prete GQ; Chatterjee P; Lee GQ; Thomas R; Brockman MA
HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome.
J Virol Volume: 92
07/01/2018 Authors: Natesampillai S; Cummins NW; Nie Z; Sampath R; Baker JV; Henry K; Pinzone M; O'Doherty U; Polley EC; Bren GD
Clinical use of lentiviral vectors.
Leukemia Volume: 32 Page(s): 1529 - 1541
07/01/2018 Authors: Milone MC; O'Doherty U
Effect of Short-Term Antiretroviral Therapy Interruption on Levels of Integrated HIV DNA.
J Virol Volume: 92
06/15/2018 Authors: Strongin Z; Sharaf R; VanBelzen DJ; Jacobson JM; Connick E; Volberding P; Skiest DJ; Gandhi RT; Kuritzkes DR; O'Doherty U
Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained.
Retrovirology Volume: 15 Page(s): 22
02/17/2018 Authors: Pinzone MR; O'Doherty U
Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs.
Retrovirology Volume: 15 Page(s): 18
02/02/2018 Authors: Baxter AE; O'Doherty U; Kaufmann DE
Rapid prediction of stem cell mobilization using volume and conductivity data from automated hematology analyzers.
Transfusion Volume: 58 Page(s): 330 - 338
02/01/2018 Authors: Villa CH; Porturas T; Sell M; Wall M; DeLeo G; Fetters J; Mignono S; Irwin L; Hwang W-T; O'Doherty U
Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs.
J Infect Volume: 75 Page(s): 555 - 571
12/01/2017 Authors: Tapia G; Hjen JF; kvist M; Olesen R; Leth S; Nissen SK; VanBelzen DJ; O'Doherty U; Mrk A; Krogsgaard K
Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.
J Virol Volume: 90 Page(s): 10436 - 10445
12/01/2016 Authors: Pinzone MR; Graf E; Lynch L; McLaughlin B; Hecht FM; Connors M; Migueles SA; Hwang W-T; Nunnari G; O'Doherty U
Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.
J Virus Erad Volume: 2 Page(s): 219 - 226
10/05/2016 Authors: Mavigner M; Lee ST; Habib J; Robinson C; Silvestri G; O'Doherty U; Chahroudi A
Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy.
Proc Natl Acad Sci U S A Volume: 113 Page(s): 8783 - 8788
08/02/2016 Authors: Imamichi H; Dewar RL; Adelsberger JW; Rehm CA; O'Doherty U; Paxinos EE; Fauci AS; Lane HC
Minor Contribution of Chimeric Host-HIV Readthrough Transcripts to the Level of HIV Cell-Associated gag RNA.
J Virol Volume: 90 Page(s): 1148 - 1151
01/15/2016 Authors: Pasternak AO; DeMaster LK; Kootstra NA; Reiss P; O'Doherty U; Berkhout B
Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.
PLoS One Volume: 11 Page(s): e0160192
01/01/2016 Authors: Lee SA; Bacchetti P; Chomont N; Fromentin R; Lewin SR; O'Doherty U; Palmer S; Richman DD; Siliciano JD; Yukl SA
A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy.
J Virol Volume: 90 Page(s): 2165 - 2179
11/04/2015 Authors: DeMaster LK; Liu X; VanBelzen DJ; Trinit B; Zheng L; Agosto LM; Migueles SA; Connors M; Sambucetti L; Levy DN
A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.
EBioMedicine Volume: 2 Page(s): 874 - 883
08/01/2015 Authors: Procopio FA; Fromentin R; Kulpa DA; Brehm JH; Bebin A-G; Strain MC; Richman DD; O'Doherty U; Palmer S; Hecht FM
Leukocytapheresis for the treatment of hyperleukocytosis secondary to acute leukemia.
Hematology Am Soc Hematol Educ Program Volume: 2014 Page(s): 457 - 460
12/05/2014 Authors: Aqui N; O'Doherty U
Association between mobilization regimen and PFS after auto-SCT for multiple myeloma.
Bone Marrow Transplant Volume: 49 Page(s): 1439 - 1441
11/01/2014 Authors: Garfall AL; Dougherty AL; Vogl DT; Weiss BM; Cohen AD; Mick R; O'Doherty U; Stadtmauer EA
Quantification of integrated HIV DNA by repetitive-sampling Alu-HIV PCR on the basis of poisson statistics.
Clin Chem Volume: 60 Page(s): 886 - 895
06/01/2014 Authors: De Spiegelaere W; Malatinkova E; Lynch L; Van Nieuwerburgh F; Messiaen P; O'Doherty U; Vandekerckhove L
CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells.
PLoS One Volume: 9 Page(s): e110731
01/01/2014 Authors: Cockerham LR; Siliciano JD; Sinclair E; O'Doherty U; Palmer S; Yukl SA; Strain MC; Chomont N; Hecht FM; Siliciano RF
The evolving role of plerixafor in hematopoietic progenitor cell mobilization.
Transfusion Volume: 53 Page(s): 2314 - 2326
10/01/2013 Authors: Tanhehco YC; Vogl DT; Stadtmauer EA; O'Doherty U
HIV latency and integration site placement in five cell-based models.
Retrovirology Volume: 10 Page(s): 90
08/16/2013 Authors: Sherrill-Mix S; Lewinski MK; Famiglietti M; Bosque A; Malani N; Ocwieja KE; Berry CC; Looney D; Shan L; Agosto LM
Improved treatment for primary HIV infection by interferon-alfa therapy? Does HCV treatment in HIV/HCV coinfected patients help us to test this hypothesis? Reply to zur Wiesch and van Lunzen.
J Infect Dis Volume: 208 Page(s): 363
07/15/2013 Authors: Azzoni L; Foulkes AS; Papasavvas E; Mexas AM; Lynn KM; Mounzer K; Tebas P; Jacobson JM; Frank I; O'Doherty U
HIV 2-long terminal repeat circular DNA is stable in primary CD4+T Cells.
Virology Volume: 441 Page(s): 18 - 21
06/20/2013 Authors: Pace MJ; Graf EH; O'Doherty U
Hematopoietic stem cells and HIV infection.
J Infect Dis Volume: 207 Page(s): 1790 - 1792
06/15/2013 Authors: Pace M; O'Doherty U
Quantitation of HIV DNA integration: effects of differential integration site distributions on Alu-PCR assays.
J Virol Methods Volume: 189 Page(s): 53 - 57
04/01/2013 Authors: Brady T; Kelly BJ; Male F; Roth S; Bailey A; Malani N; Gijsbers R; O'Doherty U; Bushman FD
Quantitation of integrated proviral DNA in viral reservoirs.
Curr Opin HIV AIDS Volume: 8 Page(s): 100 - 105
03/01/2013 Authors: Graf EH; O'Doherty U
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.
PLoS Pathog Volume: 9 Page(s): e1003174
02/01/2013 Authors: Eriksson S; Graf EH; Dahl V; Strain MC; Yukl SA; Lysenko ES; Bosch RJ; Lai J; Chioma S; Emad F
Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration.
J Infect Dis Volume: 207 Page(s): 213 - 222
01/15/2013 Authors: Azzoni L; Foulkes AS; Papasavvas E; Mexas AM; Lynn KM; Mounzer K; Tebas P; Jacobson JM; Frank I; Busch MP
Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.
PLoS Pathog Volume: 9 Page(s): e1003691
01/01/2013 Authors: Hatano H; Yukl SA; Ferre AL; Graf EH; Somsouk M; Sinclair E; Abdel-Mohsen M; Liegler T; Harvill K; Hoh R
Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected].
PLoS One Volume: 8 Page(s): e71879
01/01/2013 Authors: Graf EH; Pace MJ; Peterson BA; Lynch LJ; Chukwulebe SB; Mexas AM; Shaheen F; Martin JN; Deeks SG; Connors M
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.
AIDS Volume: 26 Page(s): 2295 - 2306
11/28/2012 Authors: Mexas AM; Graf EH; Pace MJ; Yu JJ; Papasavvas E; Azzoni L; Busch MP; Di Mascio M; Foulkes AS; Migueles SA
Towards an HIV cure: a global scientific strategy.
Nat Rev Immunol Volume: 12 Page(s): 607 - 614
07/20/2012 Authors: International AIDS Society Scientific Working Group on HIV Cure; Deeks SG; Autran B; Berkhout B; Benkirane M; Cairns S; Chomont N; Chun T-W; Churchill M; Di Mascio M
Comprehensive analysis of unique cases with extraordinary control over HIV replication.
Blood Volume: 119 Page(s): 4645 - 4655
05/17/2012 Authors: Mendoza D; Johnson SA; Peterson BA; Natarajan V; Salgado M; Dewar RL; Burbelo PD; Doria-Rose NA; Graf EH; Greenwald JH
American Society for Apheresis white paper: considerations for medical staff apheresis medicine physician credentialing and privileging.
J Clin Apher Volume: 27 Page(s): 330 - 335
01/01/2012 Authors: Andrzejewski C; Linz W; Hofmann J; O'Doherty U; Robinson RS; Arepally GM; Golden P
Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency.
PLoS Pathog Volume: 8 Page(s): e1002818
01/01/2012 Authors: Pace MJ; Graf EH; Agosto LM; Mexas AM; Male F; Brady T; Bushman FD; O'Doherty U
HIV reservoirs and latency models.
Virology Volume: 411 Page(s): 344 - 354
03/15/2011 Authors: Pace MJ; Agosto L; Graf EH; O'Doherty U
Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.
PLoS Pathog Volume: 7 Page(s): e1001300
02/01/2011 Authors: Graf EH; Mexas AM; Yu JJ; Shaheen F; Liszewski MK; Di Mascio M; Migueles SA; Connors M; O'Doherty U
Patients on HAART often have an excess of unintegrated HIV DNA: implications for monitoring reservoirs.
Virology Volume: 409 Page(s): 46 - 53
01/05/2011 Authors: Agosto LM; Liszewski MK; Mexas A; Graf E; Pace M; Yu JJ; Bhandoola A; O'Doherty U
Stem cell collection in patients with multiple myeloma: impact of induction therapy and mobilization regimen.
Bone Marrow Transplant Volume: 46 Page(s): 59 - 63
01/01/2011 Authors: Nazha A; Cook R; Vogl DT; Mangan PA; Gardler M; Hummel K; Cunningham K; Luger SM; Porter DL; Schuster S
R5 HIV env and vesicular stomatitis virus G protein cooperate to mediate fusion to naive CD4+ T Cells.
J Virol Volume: 85 Page(s): 644 - 648
01/01/2011 Authors: Pace MJ; Agosto L; O'Doherty U
Plerixafor mobilization leads to a lower ratio of CD34+ cells to total nucleated cells which results in greater storage costs.
J Clin Apher Volume: 25 Page(s): 202 - 208
01/01/2010 Authors: Tanhehco YC; Adamski J; Sell M; Cunningham K; Eisenmann C; Magee D; Stadtmauer EA; O'Doherty U
The CXCR4-tropic human immunodeficiency virus envelope promotes more-efficient gene delivery to resting CD4+ T cells than the vesicular stomatitis virus glycoprotein G envelope.
J Virol Volume: 83 Page(s): 8153 - 8162
08/01/2009 Authors: Agosto LM; Yu JJ; Liszewski MK; Baytop C; Korokhov N; Humeau LM; O'Doherty U
HIV integration site distributions in resting and activated CD4+ T cells infected in culture.
AIDS Volume: 23 Page(s): 1461 - 1471
07/31/2009 Authors: Brady T; Agosto LM; Malani N; Berry CC; O'Doherty U; Bushman F
Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells.
J Virol Volume: 83 Page(s): 4528 - 4537
05/01/2009 Authors: Dai J; Agosto LM; Baytop C; Yu JJ; Pace MJ; Liszewski MK; O'Doherty U
Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR.
Methods Volume: 47 Page(s): 254 - 260
04/01/2009 Authors: Liszewski MK; Yu JJ; O'Doherty U
A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients.
Virology Volume: 379 Page(s): 78 - 86
09/15/2008 Authors: Yu JJ; Wu TL; Liszewski MK; Dai J; Swiggard WJ; Baytop C; Frank I; Levine BL; Yang W; Theodosopoulos T
Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells.
J Virol Volume: 81 Page(s): 13938 - 13942
12/01/2007 Authors: Plesa G; Dai J; Baytop C; Riley JL; June CH; O'Doherty U
HIV-1 integrates into resting CD4+ T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration.
Virology Volume: 368 Page(s): 60 - 72
11/10/2007 Authors: Agosto LM; Yu JJ; Dai J; Kaletsky R; Monie D; O'Doherty U
A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells.
RNA Volume: 13 Page(s): 1787 - 1792
10/01/2007 Authors: Nelson PT; De Planell-Saguer M; Lamprinaki S; Kiriakidou M; Zhang P; O'Doherty U; Mourelatos Z
Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli.
J Virol Volume: 79 Page(s): 14179 - 14188
11/01/2005 Authors: Swiggard WJ; Baytop C; Yu JJ; Dai J; Li C; Schretzenmair R; Theodosopoulos T; O'Doherty U
Mechanisms of human immunodeficiency virus-1 latency.
Transfusion Volume: 45 Page(s): 88S - 91S
08/01/2005 Authors: O'Doherty U
Long HIV type 1 reverse transcripts can accumulate stably within resting CD4+ T cells while short ones are degraded.
AIDS Res Hum Retroviruses Volume: 20 Page(s): 285 - 295
03/01/2004 Authors: Swiggard WJ; O'Doherty U; McGain D; Jeyakumar D; Malim MH
A sensitive, quantitative assay for human immunodeficiency virus type 1 integration.
J Virol Volume: 76 Page(s): 10942 - 10950
11/01/2002 Authors: O'Doherty U; Swiggard WJ; Jeyakumar D; McGain D; Malim MH
cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor.
J Virol Volume: 75 Page(s): 12028 - 12038
12/01/2001 Authors: Lee B; Leslie G; Soilleux E; O'Doherty U; Baik S; Levroney E; Flummerfelt K; Swiggard W; Coleman N; Malim M
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.
J Virol Volume: 74 Page(s): 10074 - 10080
11/01/2000 Authors: O'Doherty U; Swiggard WJ; Malim MH
The dendritic cell-T cell milieu of the lymphoid tissue of the tonsil provides a locale in which SIV can reside and propagate at chronic stages of infection.
AIDS Res Hum Retroviruses Volume: 15 Page(s): 1305 - 1314
09/20/1999 Authors: Hu J; Miller CJ; O'Doherty U; Marx PA; Pope M
Immunophenotypic characterization of simian immunodeficiency virus-infected dendritic cells in cervix, vagina, and draining lymph nodes of rhesus monkeys.
Lab Invest Volume: 78 Page(s): 435 - 451
04/01/1998 Authors: Hu J; Pope M; Brown C; O'Doherty U; Miller CJ
Dendritic cells from skin and blood of macaques both promote SIV replication with T cells from different anatomical sites.
J Med Primatol Volume: 27 Page(s): 121 - 128
01/01/1998 Authors: Ignatius R; Isdell F; O'Doherty U; Pope M
Generation of monocyte-derived dendritic cells from precursors in rhesus macaque blood.
J Immunol Methods Volume: 207 Page(s): 185 - 194
09/24/1997 Authors: O'Doherty U; Ignatius R; Bhardwaj N; Pope M
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors.
J Exp Med Volume: 184 Page(s): 2433 - 2438
12/01/1996 Authors: Granelli-Piperno A; Moser B; Pope M; Chen D; Wei Y; Isdell F; O'Doherty U; Paxton W; Koup R; Mojsov S
Difficulties in obtaining monoclonal antibodies to subsets of human leukocytes, using neonatal tolerance induction in mice.
J Immunol Methods Volume: 181 Page(s): 115 - 124
04/12/1995 Authors: Yamaguchi Y; O'Doherty U; Peng M; Steinman RM
Susceptibility of dendritic cells to HIV-1 infection in vitro.
J Leukoc Biol Volume: 56 Page(s): 257 - 265
09/01/1994 Authors: Cameron PU; Lowe MG; Crowe SM; O'Doherty U; Pope M; Gezelter S; Steinman RM
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.
Immunology Volume: 82 Page(s): 487 - 493
07/01/1994 Authors: O'Doherty U; Peng M; Gezelter S; Swiggard WJ; Betjes M; Bhardwaj N; Steinman RM
Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.
J Exp Med Volume: 178 Page(s): 1067 - 1076
09/01/1993 Authors: O'Doherty U; Steinman RM; Peng M; Cameron PU; Gezelter S; Kopeloff I; Swiggard WJ; Pope M; Bhardwaj N
Tolerizing mice to human leukocytes: a step toward the production of monoclonal antibodies specific for human dendritic cells.
Adv Exp Med Biol Volume: 329 Page(s): 165 - 172
01/01/1993 Authors: O'Doherty U; Swiggard WJ; Inaba K; Yamaguchi Y; Kopeloff I; Bhardwaj N; Steinman RM

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Profile

Una O'Doherty

Overview

Academic Appointment

Education

Degrees

Research

Focus

Blood cells in health and disease

Publications