Publications

• Microbial amyloids in neurodegenerative amyloid diseases.
  FEBS J Volume: 292 Page(s): 1265 - 1281
  03/01/2025 Authors: Sampson T
• Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.
  bioRxiv
  02/22/2025 Authors: Blackmer-Raynolds L; Sampson MM; Kozlov A; Yang A; Lipson L; Hamilton AM; Kelly SD; Chopra P; Chang J; Sloan SA
• Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models.
  Sci Rep Volume: 15 Page(s): 4631
  02/07/2025 Authors: Blackmer-Raynolds L; Lipson LD; Fraccaroli I; Krout IN; Chang J; Sampson TR
• Alpha synuclein overexpression can drive microbiome dysbiosis in mice.
  Sci Rep Volume: 15 Page(s): 4014
  02/01/2025 Authors: Sampson TR; Wallen ZD; Won W-J; Standaert DG; Payami H; Harms AS
• Lewy body diseases and the gut.
  Mol Neurodegener Volume: 20 Page(s): 14
  01/30/2025 Authors: Sampson TR; Tansey MG; West AB; Liddle RA
• The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract.
  
  12/17/2024 Authors: White AC; Krout IN; Mouhi S; Chang J; Kelly SD; Caudle WM; Sampson TR
• Microbiome-based therapeutics for Parkinson's disease.
  Neurotherapeutics Volume: 21 Page(s): e00462
  10/01/2024 Authors: Hamilton AM; Krout IN; White AC; Sampson TR
• Fecal Microbiome Transplants For Parkinson Disease.
  JAMA Neurol Volume: 81 Page(s): 911 - 913
  09/01/2024 Authors: Sampson TR
• Diet-microbiome interactions promote enteric nervous system resilience following spinal cord injury.
  NPJ Biofilms Microbiomes Volume: 10 Page(s): 75
  08/29/2024 Authors: Hamilton AM; Blackmer-Raynolds L; Li Y; Kelly SD; Kebede N; Williams AE; Chang J; Garraway SM; Srinivasan S; Sampson TR
• Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease.
  Neurobiol Dis Volume: 196 Page(s): 106511
  06/15/2024 Authors: Rodrigues MEDS; Bolen ML; Blackmer-Raynolds L; Schwartz N; Chang J; Tansey MG; Sampson TR
• Diet-microbiome interactions promote enteric nervous system resilience following spinal cord injury.
  
  06/08/2024 Authors: Hamilton AM; Blackmer-Raynolds L; Li Y; Kelly S; Kebede N; Williams A; Chang J; Garraway SM; Srinivasan S; Sampson TR
• Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease.
  
  02/28/2024 Authors: De Sousa Rodrigues ME; Bolen ML; Blackmer-Raynolds L; Schwartz N; Chang J; Tansey MG; Sampson TR
• Circulating Extracellular Vesicles as a Potential Mediator of Synuclein Pathology in the Gut.
  Mov Disord Volume: 39 Page(s): 3 - 5
  01/01/2024 Authors: Sampson TR
• Population fraction of Parkinson's disease attributable to preventable risk factors.
  NPJ Parkinsons Dis Volume: 9 Page(s): 159
  12/05/2023 Authors: Payami H; Cohen G; Murchison CF; Sampson TR; Standaert DG; Wallen ZD
• Overview of the Gut Microbiome.
  Semin Neurol Volume: 43 Page(s): 518 - 529
  08/01/2023 Authors: Blackmer-Raynolds L; Sampson TR
• Population fraction of Parkinson's disease attributable to preventable risk factors.
  medRxiv
  05/19/2023 Authors: Payami H; Cohen G; Murchison CF; Sampson TR; Standaert DG; Wallen ZD
• Revealing gut microbiome associations with CFS.
  Cell Host Microbe Volume: 31 Page(s): 171 - 172
  02/08/2023 Authors: Sampson TR
• Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model.
  Front Cell Neurosci Volume: 17 Page(s): 895017
  01/01/2023 Authors: MacPherson KP; Eidson LN; Houser MC; Weiss BE; Gollihue JL; Herrick MK; de Sousa Rodrigues ME; Sniffen L; Weekman EM; Hamilton AM
• Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms.
  Nat Commun Volume: 13 Page(s): 6958
  11/15/2022 Authors: Wallen ZD; Demirkan A; Twa G; Cohen G; Dean MN; Standaert DG; Sampson TR; Payami H
• Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation.
  Gut Volume: 71 Page(s): 2233 - 2252
  11/01/2022 Authors: Chen C; Liao J; Xia Y; Liu X; Jones R; Haran J; McCormick B; Sampson TR; Alam A; Ye K
• Uncovering Wide-Spread Dysbiosis at Species-Level Resolution Implicates the Gut Microbiome in Multiple Parkinson Disease Pathologies
  Volume: 92 Page(s): S127 - S127
  10/01/2022 Authors: Wallen ZD; Demirkan A; Twa G; Cohen G; Dean MN; Standaert DG; Sampson T; Payami H
• The gut-brain axis goes viral.
  Cell Host Microbe Volume: 30 Page(s): 283 - 285
  03/09/2022 Authors: Blackmer-Raynolds LD; Sampson TR
• Traumatic spinal cord injury and the contributions of the post-injury microbiome.
  Volume: 167 Page(s): 251 - 290
  01/01/2022 Authors: Hamilton AM; Sampson TR
• Introduction: Unraveling the complex contributions of indigenous microbes to neurological health and disease.
  Volume: 167 Page(s): xi - xvi
  01/01/2022 Authors: Sampson TR
• MICROBIOME ALTERATIONS LEAD TO IMPAIRED GASTROINTESTINAL MOTILITY FOLLOWING SPINAL CORD INJURY
  Volume: 160 Page(s): S735 - S735
  05/01/2021 Authors: Hamilton AM; Chang J; Garraway SM; Srinivasan S; Sampson TR
• A PILOT STUDY ON PATIENTS WITH FECAL INCONTINENCE REVEALS DISEASE-ASSOCIATED ALTERATIONS IN MICROBIOME THAT MAY CONTRIBUTE TO DISEASE PATHOPHYSIOLOGY
  Volume: 160 Page(s): S499 - S499
  05/01/2021 Authors: Raja S; Hamilton AM; Li G; Mwangi SM; Chassaing B; Gewirtz AT; Vaughan EC; Sampson TR; Srinivasan S
• Gut-seeded -synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice.
  Nat Neurosci Volume: 23 Page(s): 327 - 336
  03/01/2020 Authors: Challis C; Hori A; Sampson TR; Yoo BB; Challis RC; Hamilton AM; Mazmanian SK; Volpicelli-Daley LA; Gradinaru V
• A gut bacterial amyloid promotes -synuclein aggregation and motor impairment in mice.
  Elife Volume: 9
  02/11/2020 Authors: Sampson TR; Challis C; Jain N; Moiseyenko A; Ladinsky MS; Shastri GG; Thron T; Needham BD; Horvath I; Debelius JW
• The impact of indigenous microbes on Parkinson's disease.
  Neurobiol Dis Volume: 135 Page(s): 104426
  02/01/2020 Authors: Sampson T
• Author Correction: A CRISPR/Cas system mediates bacterial innate immune evasion and virulence.
  Nature Volume: 570 Page(s): E30 - E31
  06/01/2019 Authors: Sampson TR; Saroj SD; Llewellyn AC; Tzeng Y-L; Weiss DS
• Defining Dysbiosis in Disorders of Movement and Motivation.
  J Neurosci Volume: 38 Page(s): 9414 - 9422
  10/31/2018 Authors: Fields CT; Sampson TR; Bruce-Keller AJ; Kiraly DD; Hsiao EY; de Vries GJ
• Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
  Cell Volume: 167 Page(s): 1469 - 1480.e12
  12/01/2016 Authors: Sampson TR; Debelius JW; Thron T; Janssen S; Shastri GG; Ilhan ZE; Challis C; Schretter CE; Rocha S; Gradinaru V
• Overview of CRISPR-Cas9 Biology.
  Cold Spring Harb Protoc Volume: 2016 Page(s): pdb.top088849
  12/01/2016 Authors: Ratner HK; Sampson TR; Weiss DS
• The Central Nervous System and the Gut Microbiome.
  Cell Volume: 167 Page(s): 915 - 932
  11/03/2016 Authors: Sharon G; Sampson TR; Geschwind DH; Mazmanian SK
• I can see CRISPR now, even when phage are gone: a view on alternative CRISPR-Cas functions from the prokaryotic envelope.
  Curr Opin Infect Dis Volume: 28 Page(s): 267 - 274
  06/01/2015 Authors: Ratner HK; Sampson TR; Weiss DS
• Control of brain development, function, and behavior by the microbiome.
  Cell Host Microbe Volume: 17 Page(s): 565 - 576
  05/13/2015 Authors: Sampson TR; Mazmanian SK
• Cas9-mediated targeting of viral RNA in eukaryotic cells.
  Proc Natl Acad Sci U S A Volume: 112 Page(s): 6164 - 6169
  05/12/2015 Authors: Price AA; Sampson TR; Ratner HK; Grakoui A; Weiss DS
• A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion.
  Proc Natl Acad Sci U S A Volume: 111 Page(s): 11163 - 11168
  07/29/2014 Authors: Sampson TR; Napier BA; Schroeder MR; Louwen R; Zhao J; Chin C-Y; Ratner HK; Llewellyn AC; Jones CL; Laroui H
• CRISPR-Cas systems: new players in gene regulation and bacterial physiology.
  Front Cell Infect Microbiol Volume: 4 Page(s): 37
  01/01/2014 Authors: Sampson TR; Weiss DS
• Exploiting CRISPR/Cas systems for biotechnology.
  Bioessays Volume: 36 Page(s): 34 - 38
  01/01/2014 Authors: Sampson TR; Weiss DS
• Cas9-dependent endogenous gene regulation is required for bacterial virulence.
  Biochem Soc Trans Volume: 41 Page(s): 1407 - 1411
  12/01/2013 Authors: Sampson TR; Weiss DS
• Degeneration of a CRISPR/Cas system and its regulatory target during the evolution of a pathogen.
  RNA Biol Volume: 10 Page(s): 1618 - 1622
  10/01/2013 Authors: Sampson TR; Weiss DS
• A CRISPR/Cas system mediates bacterial innate immune evasion and virulence.
  Nature Volume: 497 Page(s): 254 - 257
  05/09/2013 Authors: Sampson TR; Saroj SD; Llewellyn AC; Tzeng Y-L; Weiss DS
• Alternative roles for CRISPR/Cas systems in bacterial pathogenesis.
  PLoS Pathog Volume: 9 Page(s): e1003621
  01/01/2013 Authors: Sampson TR; Weiss DS
• Rapid killing of Acinetobacter baumannii by polymyxins is mediated by a hydroxyl radical death pathway.
  Antimicrob Agents Chemother Volume: 56 Page(s): 5642 - 5649
  11/01/2012 Authors: Sampson TR; Liu X; Schroeder MR; Kraft CS; Burd EM; Weiss DS
• Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition.
  Cell Microbiol Volume: 14 Page(s): 1531 - 1543
  10/01/2012 Authors: Jones CL; Sampson TR; Nakaya HI; Pulendran B; Weiss DS
• Subversion of host recognition and defense systems by Francisella spp.
  Microbiol Mol Biol Rev Volume: 76 Page(s): 383 - 404
  06/01/2012 Authors: Jones CL; Napier BA; Sampson TR; Llewellyn AC; Schroeder MR; Weiss DS
• Mycobacteriophages BPs, Angel and Halo: comparative genomics reveals a novel class of ultra-small mobile genetic elements.
  Microbiology (Reading) Volume: 155 Page(s): 2962 - 2977
  09/01/2009 Authors: Sampson T; Broussard GW; Marinelli LJ; Jacobs-Sera D; Ray M; Ko C-C; Russell D; Hendrix RW; Hatfull GF