Thota Ganesh PhD
- Department of Pharmacology & Chemical Biology
Associate Professor
- (404) 727-7393
- tganesh@emory.edu
- My service/philonthapic activities
- My Laboratory
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Emory University School of Medicine
Pharmacology
1510 Clifton Rd, Room 5019
Overview
The overall goal of my research is to work with disease oriented biomedical research investigators to develop small molecule drugs for a variety of medically unmet CNS and peripheral diseases. We currently focussing on to develop novel small molecule therapeutic agents to treat Alzheimer's disease and Epilepsy.
Academic Appointment
- Associate Professor, Pharmacology, Emory University School of Medicine
Education
Degrees
- PhD from Osmania University
- BS from Osmania University
- PhD from Osmania University
Research
Publications
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Toll-like receptor 7 (TLR7)-mediated antiviral response protects mice from lethal SARS-CoV-2 infection.
J Virol Volume: 99 Page(s): e0166824
05/20/2025 Authors: Ghimire R; Shrestha R; Amaradhi R; Liu L; More S; Ganesh T; Ford AK; Channappanavar R -
Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion.
iScience Volume: 27 Page(s): 109591
04/19/2024 Authors: Knippler CM; Arnst JL; Robinson IE; Matsuk V; Khatib TO; Harvey RD; Shanmugam M; Mouw JK; Fu H; Ganesh T -
Novel NADPH Oxidase-2 Inhibitors as Potential Anti-Inflammatory and Neuroprotective Agents.
Antioxidants (Basel) Volume: 12
08/23/2023 Authors: Juric M; Rawat V; Amaradhi R; Zielonka J; Ganesh T -
Targeting EP2 Receptor for Drug Discovery: Strengths, Weaknesses, Opportunities, and Threats (SWOT) Analysis.
J Med Chem Volume: 66 Page(s): 9313 - 9324
07/27/2023 Authors: Ganesh T -
Preclinical development of an EP2 antagonist for post-seizure cognitive deficits.
Neuropharmacology Volume: 224 Page(s): 109356
02/15/2023 Authors: Varvel NH; Amaradhi R; Espinosa-Garcia C; Duddy S; Franklin R; Banik A; Alemn-Ruiz C; Blackmer-Raynolds L; Wang W; Honore T -
Temporal Expression of Neuroinflammatory and Oxidative Stress Markers and Prostaglandin E2 Receptor EP2 Antagonist Effect in a Rat Model of Epileptogenesis.
ACS Pharmacol Transl Sci Volume: 6 Page(s): 128 - 138
01/13/2023 Authors: Rawat V; Eastman CL; Amaradhi R; Banik A; Fender JS; Dingledine RJ; D'Ambrosio R; Ganesh T -
Pharmacological antagonism of EP2 receptor does not modify basal cardiovascular and respiratory function, blood cell counts, and bone morphology in animal models.
Biomed Pharmacother Volume: 147 Page(s): 112646
03/01/2022 Authors: Rawat V; Banik A; Amaradhi R; Rojas A; Taval S; Nagy T; Dingledine R; Ganesh T -
Second-Generation Prostaglandin Receptor EP2 Antagonist, TG8-260, with High Potency, Selectivity, Oral Bioavailability, and Anti-Inflammatory Properties.
ACS Pharmacol Transl Sci Volume: 5 Page(s): 118 - 133
02/11/2022 Authors: Amaradhi R; Mohammed S; Banik A; Franklin R; Dingledine R; Ganesh T -
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.
Nat Metab Volume: 3 Page(s): 1694 - 1705
12/01/2021 Authors: Liu KH; Owens JA; Saeedi B; Cohen CE; Bellissimo MP; Naudin C; Darby T; Druzak S; Maner-Smith K; Orr M -
Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer's disease.
J Neuroinflammation Volume: 18 Page(s): 273
11/20/2021 Authors: Banik A; Amaradhi R; Lee D; Sau M; Wang W; Dingledine R; Ganesh T