Tamara Caspary PhD
- Department of Human Genetics
Professor
- (404) 727-9862
- tcaspar@emory.edu
- Caspary Lab
-
615 Michael Street
Suite 305P
Atlanta, GA 30322
Academic Appointment
- Professor, Department of Human Genetics, Emory University School of Medicine
Education
Degrees
- PhD from Princeton University
- BS from The University of North Carolina
- MA from Princeton University
Research
Focus
- We ask directly which genes are important for development of the mammalian nervous system by performing chemical mutagenesis screens in the mouse. We have identified several mutant lines with defects in neural development. After identifying the novel protein, we combine molecular, cellular and genetic approaches to define the molecular mechanisms governing cell fate decisions. Through this work several projects in the lab focus on the role of cilia proteins in vertebrate Hedgehog signaling.
Publications
-
Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling.
J Cell Sci Volume: 138
10/15/2025 Authors: Bear R; Sloan SA; Caspary T -
ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and reveals a role for ARL13B in spermatogenesis.
bioRxiv
03/26/2025 Authors: Long AB; Wilson IM; Terry TT; Van Sciver RE; Caspary T -
In vivo genetic labeling of primary cilia in developing astrocytes.
bioRxiv
03/19/2025 Authors: Bear R; Wei C; Caspary T -
Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling.
10/17/2024 Authors: Bear R; Sloan SA; Caspary T -
A prioritization tool for cilia-associated genes and their in vivo resources unveils new avenues for ciliopathy research.
Dis Model Mech Volume: 17
10/01/2024 Authors: Van Sciver RE; Caspary T -
GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade.
bioRxiv
04/18/2024 Authors: Walker MF; Zhang J; Steiner W; Ku P-I; Zhu J-F; Michaelson Z; Yen Y-C; Lee A; Long AB; Casey MJ -
Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
Cells Volume: 13
01/30/2024 Authors: Brewer KK; Brewer KM; Terry TT; Caspary T; Vaisse C; Berbari NF -
Ciliary ARL13B prevents obesity in mice.
bioRxiv
08/04/2023 Authors: Terry TT; Gigante ED; Alexandre CM; Brewer KM; Engle SE; Yue X; Berbari NF; Vaisse C; Caspary T -
Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse.
bioRxiv
05/15/2023 Authors: Van Sciver RE; Long AB; Katz HG; Gigante ED; Caspary T