Publications

• Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome.
  Sci Adv Volume: 11 Page(s): eadi9885
  03/21/2025 Authors: Hargarten JC; Ssebambulidde K; Anjum SH; Vaughan MJ; Xu J; Ganguly A; Dulek B; Otaizo-Carrasquero F; Song B; Tao S
• Development of robust antiviral assays using relevant apical-out human airway organoids.
  bioRxiv
  07/12/2024 Authors: Lee J-H; LeCher JC; Parigoris E; Shinagawa N; Sentosa J; Manfredi C; Goh SL; De R; Tao S; Zandi K
• SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
  Blood Volume: 143 Page(s): 1953 - 1964
  05/09/2024 Authors: Abdelrazak Morsy MH; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B
• Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
  Eur J Med Chem Volume: 268 Page(s): 116263
  03/15/2024 Authors: Amblard F; LeCher JC; De R; Zhou S; Liu P; Goh SL; Tao S; Patel D; Downs-Bowen J; Zandi K
• Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
  Nucleic Acids Res Volume: 52 Page(s): 1207 - 1225
  02/09/2024 Authors: Xu P; Yang T; Kundnani DL; Sun M; Marsili S; Gombolay AL; Jeon Y; Newnam G; Balachander S; Bazzani V
• SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
  Blood Volume: 143 Page(s): 1953 - 1964
  01/18/2024 Authors: Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B
• Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
  Bioorg Chem Volume: 141 Page(s): 106923
  12/01/2023 Authors: Amblard F; Chen Z; Wiseman J; Zhou S; Liu P; Salman M; Verma K; Azadi N; Downs-Bowen J; Tao S
• Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages.
  J Biol Chem Volume: 299 Page(s): 104984
  08/01/2023 Authors: Bowen NE; Tao S; Cho Y-J; Schinazi RF; Kim B
• Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial.
  J Intern Med Volume: 292 Page(s): 925 - 940
  12/01/2022 Authors: Jdersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzn S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G
• Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice.
  Microorganisms Volume: 10
  10/22/2022 Authors: LeCher JC; Zandi K; Costa VV; Amblard F; Tao S; Patel D; Lee S; da Silva Santos FR; Goncalves MR; Queroz-Junior CM
• Pharmacokinetics of Ruxolitinib in HIV Suppressed Individuals on Antiretroviral Agent Therapy from the ACTG A5336 Study.
  J Clin Pharmacol Volume: 61 Page(s): 1555 - 1566
  12/01/2021 Authors: Hurwitz SJ; Tao S; Gavegnano C; Jiang Y; Tressler RL; Tsibris A; Del Rio C; Overton ET; Lederman MM; Kantor A
• Disproportionate presence of adenosine in mitochondrial and chloroplast DNA of Chlamydomonas reinhardtii.
  iScience Volume: 24 Page(s): 102005
  01/22/2021 Authors: El-Sayed WMM; Gombolay AL; Xu P; Yang T; Jeon Y; Balachander S; Newnam G; Tao S; Bowen NE; Brna T
• Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
  Cell Volume: 184 Page(s): 460 - 475.e21
  01/21/2021 Authors: Hoang TN; Pino M; Boddapati AK; Viox EG; Starke CE; Upadhyay AA; Gumber S; Nekorchuk M; Busman-Sahay K; Strongin Z
• Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator.
  Viruses Volume: 13
  01/15/2021 Authors: Hurwitz SJ; McBrearty N; Arzumanyan A; Bichenkov E; Tao S; Bassit L; Chen Z; Kohler JJ; Amblard F; Feitelson MA
• Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
  Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
  01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
• Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
  bioRxiv
  09/16/2020 Authors: Hoang TN; Pino M; Boddapati AK; Viox EG; Starke CE; Upadhyay AA; Gumber S; Busman-Sahay K; Strongin Z; Harper JL
• Erratum for Amblard et al., "Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice".
  Antimicrob Agents Chemother Volume: 64
  08/20/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
• Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine.
  Nat Commun Volume: 11 Page(s): 2447
  05/15/2020 Authors: Balachander S; Gombolay AL; Yang T; Xu P; Newnam G; Keskin H; El-Sayed WMM; Bryksin AV; Tao S; Bowen NE
• The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression.
  Transl Oncol Volume: 13 Page(s): 100751
  04/01/2020 Authors: Li Z; Sun C; Tao S; Osunkoya AO; Arnold RS; Petros JA; Zu X; Moreno CS
• Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
  EMBO Mol Med Volume: 12 Page(s): e10419
  03/06/2020 Authors: Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CB; Sandhow L; Kutzner J; Hed Myrberg I; Bunten SS; Axelsson H; Zhang SM
• Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.
  Antimicrob Agents Chemother Volume: 64
  01/27/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
• Intracellular metabolism and potential cardiotoxicity of a -D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.
  Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 204 - 224
  01/01/2020 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Ehteshami M; Jiang Y; Amblard F; Coats SJ
• Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro.
  J Neuroinflammation Volume: 16 Page(s): 182
  09/27/2019 Authors: Gavegnano C; Haile WB; Hurwitz S; Tao S; Jiang Y; Schinazi RF; Tyor WR
• Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
  Antimicrob Agents Chemother Volume: 63
  09/01/2019 Authors: Zandi K; Amblard F; Amichai S; Bassit L; Tao S; Jiang Y; Zhou L; Ollinger Russell O; Mengshetti S; Schinazi RF
• Discovery of a Series of 2'--Fluoro,2'--bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
  J Med Chem Volume: 62 Page(s): 1859 - 1874
  02/28/2019 Authors: Mengshetti S; Zhou L; Sari O; De Schutter C; Zhang H; Cho JH; Tao S; Bassit LC; Verma K; Domaoal RA
• Long-term virological and adherence outcomes to antiviral treatment in a 4-year cohort chronic HBV study.
  Antivir Ther Volume: 24 Page(s): 567 - 579
  01/01/2019 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Ferreira AS; Hori PC; Ganova-Raeva LM; Khudyakov Y; Schinazi RF; Carrilho FJ
• Disparate effects of cytotoxic chemotherapy on the antiviral activity of antiretroviral therapy: implications for treatments of HIV-infected cancer patients.
  Antivir Ther Volume: 24 Page(s): 177 - 186
  01/01/2019 Authors: Medina-Moreno S; Zapata JC; Cottrell ML; Le NM; Tao S; Bryant J; Sausville E; Schinazi RF; Kashuba AD; Redfield RR
• Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex.
  Nucleic Acids Res Volume: 46 Page(s): 9711 - 9725
  10/12/2018 Authors: Handa S; Jiang Y; Tao S; Foreman R; Schinazi RF; Miller JF; Ghosh P
• HIV transmission in discordant couples in Africa in the context of antiretroviral therapy availability.
  AIDS Volume: 32 Page(s): 1613 - 1623
  07/31/2018 Authors: Woodson E; Goldberg A; Michelo C; Basu D; Tao S; Schinazi R; Jiang Y; Kilembe W; Karita E; Allen S
• Baricitinib Reverses HIV Associated Neurocognitive Disorders in a SCID Murine Model
  Volume: 24 Page(s): S29 - S29
  04/01/2018 Authors: Gavegnano C; Haile W; Koneru R; Tao S; Hurwitz S; Schinazi R; Tyor W
• Baricitinib Reverses HIV Associated Neurocognitive Disorders in a SCID Murine Model
  Volume: 13 Page(s): S29 - S29
  04/01/2018 Authors: Gavegnano C; Haile W; Koneru R; Tao S; Hurwitz S; Schinazi R; Tyor W
• 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
  J Med Chem Volume: 60 Page(s): 5424 - 5437
  07/13/2017 Authors: Zhou S; Mahmoud S; Liu P; Zhou L; Ehteshami M; Bassit L; Tao S; Domaoal RA; Sari O; Schutter CD
• Pharmacokinetics and Placental Transfer of Elvitegravir, Dolutegravir, and Other Antiretrovirals during Pregnancy.
  Antimicrob Agents Chemother Volume: 61
  06/01/2017 Authors: Rimawi BH; Johnson E; Rajakumar A; Tao S; Jiang Y; Gillespie S; Schinazi RF; Mirochnick M; Badell ML; Chakraborty R
• Characterization of -d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
  Antimicrob Agents Chemother Volume: 61
  04/01/2017 Authors: Ehteshami M; Tao S; Zandi K; Hsiao H-M; Jiang Y; Hammond E; Amblard F; Russell OO; Merits A; Schinazi RF
• Substrates and Inhibitors of SAMHD1.
  PLoS One Volume: 12 Page(s): e0169052
  01/01/2017 Authors: Hollenbaugh JA; Shelton J; Tao S; Amiralaei S; Liu P; Lu X; Goetze RW; Zhou L; Nettles JH; Schinazi RF
• Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study.
  Lancet Gastroenterol Hepatol Volume: 1 Page(s): 97 - 104
  10/01/2016 Authors: Lau G; Benhamou Y; Chen G; Li J; Shao Q; Ji D; Li F; Li B; Liu J; Hou J
• Semi-quantitative Detection of HIV-1 RNA in Plasma Using an In-house RT-PCR Technique for Monitoring Self-reported Antiretroviral Treatment Adherence
  Volume: 32 Page(s): 409 - 409
  10/01/2016 Authors: Michelo C; Sharkey T; Mfune T; Basu D; Tao S; Jiang Y; Schinazi R; Kilembe W; Allen S; Hunter E
• Acute HIV-1 Transmission in Zambian Couples in the Post-HAART Era: Treatment Failure or Lack of Adherence?
  Volume: 32 Page(s): 257 - 257
  10/01/2016 Authors: Woodson E; Basu D; Goldberg A; Kilembe W; Inambao M; Tao S; Schinazi R; Hunter E; Allen S
• Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
  Antimicrob Agents Chemother Volume: 60 Page(s): 4659 - 4669
  08/01/2016 Authors: Ehteshami M; Tao S; Ozturk T; Zhou L; Cho JH; Zhang H; Amiralaei S; Shelton JR; Lu X; Khalil A
• The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model.
  Neurobiol Dis Volume: 92 Page(s): 137 - 143
  08/01/2016 Authors: Haile WB; Gavegnano C; Tao S; Jiang Y; Schinazi RF; Tyor WR
• Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.
  ACS Med Chem Lett Volume: 7 Page(s): 17 - 22
  01/14/2016 Authors: Zhou L; Zhang H; Tao S; Ehteshami M; Cho JH; McBrayer TR; Tharnish P; Whitaker T; Amblard F; Coats SJ
• Four years real-life experience with antiviral adherence in chronic hepatitis B infection in a tertiary university hospital
  Volume: 62 Page(s): 963A - 963A
  10/01/2015 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Paranagua-Vezozzo D; Schinazi RF; Carrilho FJ; Ono SK
• Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
  Bioorg Med Chem Lett Volume: 25 Page(s): 3711 - 3715
  09/01/2015 Authors: Boucle S; Tao S; Amblard F; Stanton RA; Nettles JH; Li C; McBrayer TR; Whitaker T; Coats SJ; Schinazi RF
• Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients.
  AIDS Volume: 29 Page(s): 1113 - 1115
  06/01/2015 Authors: Lahiri CD; Tao S; Jiang Y; Sheth AN; Acosta EP; Marconi VC; Armstrong WS; Schinazi RF; Vunnava A; Sanford S
• -D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
  J Med Chem Volume: 58 Page(s): 3445 - 3458
  04/23/2015 Authors: Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Pradere U; Cho JH
• Nonlinear dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
  PURINERGIC SIGNALLING Volume: 10 Page(s): 696 - 696
  12/01/2014 Authors: Hollenbaugh JA; Tao S; Lenzi G; Ryu S; Kim D-H; Schinazi RF; Kim B
• Lack of Awareness of Human Immunodeficiency Virus (HIV) Infection: Problems and Solutions With Self-reported HIV Serostatus of Men Who Have Sex With Men.
  Open Forum Infect Dis Volume: 1 Page(s): ofu084
  09/01/2014 Authors: Sanchez TH; Kelley CF; Rosenberg E; Luisi N; O'Hara B; Lambert R; Coleman R; Frew P; Salazar LF; Tao S
• dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.
  Retrovirology Volume: 11 Page(s): 63
  08/27/2014 Authors: Hollenbaugh JA; Tao S; Lenzi GM; Ryu S; Kim D-H; Diaz-Griffero F; Schinazi RF; Kim B
• Enhanced antiretroviral therapy in rhesus macaques improves RT-SHIV viral decay kinetics.
  Antimicrob Agents Chemother Volume: 58 Page(s): 3927 - 3933
  07/01/2014 Authors: North TW; Villalobos A; Hurwitz SJ; Deere JD; Higgins J; Chatterjee P; Tao S; Kauffman RC; Luciw PA; Kohler JJ
• Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women.
  Antimicrob Agents Chemother Volume: 58 Page(s): 4014 - 4019
  07/01/2014 Authors: Geisler WM; Pascual MLG; Mathew J; Koltun WD; Morgan F; Batteiger BE; Mayes A; Tao S; Hurwitz SJ; Sayada C
• Comparison of Three 2 '-C-Methyl Guanosine Prodrugs for Hepatitis C including a Novel beta-D-2 '-C-Me-2,6-Diaminopurine Ribonucleoside Phosphoramidate (RS-1389): Interspecies Hepatocyte and Human Cardiomyocyte Metabolism Profiles
  Volume: 60 Page(s): 1170A - 1171A
  01/01/2014 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Coats SJ; Schinazi RF
• A 4-N-Hydroxycytidine Ribonucleoside Phosphoramidate Delivers Intracellularly Three Distinct Active 5 '-Triphosphate Nucleosides that are Potent Inhibitors of HCV Polymerase
  Volume: 60 Page(s): 1162A - 1162A
  01/01/2014 Authors: Schinazi RF; Amblard F; Tao S; Ehteshami M; Amiralaei S; Li H; Shelton J; Whitaker T; McBrayer TR; Coats SJ
• Phosphoramidate Prodrugs of beta-D-2 '-C-Me-2,6-diaminopurine Ribonucleoside are Potent Inhibitors of Hepatitis C Virus (HCV) Replication Delivering Two Active Nucleoside Triphosphates
  Volume: 58 Page(s): 437A - 437A
  10/01/2013 Authors: Schinazi RF; Zhou L; Zhang H; Ehteshami M; Tao S; Bassit LC; Suesserman J; Whitaker T; McBrayer TR; Cho J-H
• Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.
  ACS Med Chem Lett Volume: 4 Page(s): 747 - 751
  08/08/2013 Authors: Bondada L; Detorio M; Bassit L; Tao S; Montero CM; Singletary TM; Zhang H; Zhou L; Cho J-H; Coats SJ
• NOVEL EFFECTOR OF HBV CAPSID ASSEMBLY REDUCES THE ACTIVITY OF cccDNA AND INTERACTS SYNERGISTICALLY WITH NUCLEOSIDE ANALOGS IN THE HUMAN HEPATOCYTES
  Volume: 58 Page(s): S298 - S299
  04/01/2013 Authors: Bassit L; Ozturk T; Tao S; Boucle SR; Ehteshami M; Zlotnick A; Feitelson MA; Schinazi RF
• beta-D-2 '-C-Me-2,6-diaminopurine ribonucleoside phosphoramidates are potent and selective inhibitors of hepatitis C virus (HCV) and are bioconverted intracellularly to bioactive 2,6-diaminopurine- and guanosine-5 '-triphosphate forms
  Volume: 18 Page(s): A57 - A57
  01/01/2013 Authors: Schinazi RF; Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Detorio M
• Biochemical characterization of beta-D-2 '-C-methyl-2,6-diaminopurine-ribonucleoside-5 '-triphosphate as a potent inhibitor of hepatitis C virus (HCV) polymerase
  Volume: 18 Page(s): A10 - A10
  01/01/2013 Authors: Ehteshami M; Amiralaei S; Shelton JR; Tao S; Suesserman JE; Zhang H-W; Zhou L; Coats SJ; Schinazi RF
• Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
  Drug Metab Dispos Volume: 40 Page(s): 2307 - 2314
  12/01/2012 Authors: Cheng C; Yang M; Yu K; Guan S; Tao S; Millar A; Pang X; Guo D
• Synthesis and evaluation of novel potent HCV NS5A inhibitors.
  Bioorg Med Chem Lett Volume: 22 Page(s): 4864 - 4868
  07/15/2012 Authors: Zhang H; Zhou L; Amblard F; Shi J; Bobeck DR; Tao S; McBrayer TR; Tharnish PM; Whitaker T; Coats SJ
• Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
  Eur J Med Chem Volume: 46 Page(s): 3832 - 3844
  09/01/2011 Authors: Zhang H-W; Detorio M; Herman BD; Solomon S; Bassit L; Nettles JH; Obikhod A; Tao S-J; Mellors JW; Sluis-Cremer N
• Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans.
  Antivir Ther Volume: 16 Page(s): 1123 - 1130
  01/01/2011 Authors: van Maarseveen NM; Wensing AM; de Jong D; Beilhartz GL; Obikhod A; Tao S; Pingen M; Arends JE; Hoepelman AI; Schinazi RF