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Profile

Sijia Tao

  • Department of Pediatrics
    Assistant Professor
  • sijia.tao@emory.edu
Head shot of Sijia Tao

Research

Publications

  • Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome.
    Sci Adv Volume: 11 Page(s): eadi9885
    03/21/2025 Authors: Hargarten JC; Ssebambulidde K; Anjum SH; Vaughan MJ; Xu J; Ganguly A; Dulek B; Otaizo-Carrasquero F; Song B; Tao S
  • Development of robust antiviral assays using relevant apical-out human airway organoids.
    bioRxiv
    07/12/2024 Authors: Lee J-H; LeCher JC; Parigoris E; Shinagawa N; Sentosa J; Manfredi C; Goh SL; De R; Tao S; Zandi K
  • SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
    Blood Volume: 143 Page(s): 1953 - 1964
    05/09/2024 Authors: Abdelrazak Morsy MH; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B
  • Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
    Eur J Med Chem Volume: 268 Page(s): 116263
    03/15/2024 Authors: Amblard F; LeCher JC; De R; Zhou S; Liu P; Goh SL; Tao S; Patel D; Downs-Bowen J; Zandi K
  • Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
    Nucleic Acids Res Volume: 52 Page(s): 1207 - 1225
    02/09/2024 Authors: Xu P; Yang T; Kundnani DL; Sun M; Marsili S; Gombolay AL; Jeon Y; Newnam G; Balachander S; Bazzani V
  • SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
    Blood Volume: 143 Page(s): 1953 - 1964
    01/18/2024 Authors: Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B
  • Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
    Bioorg Chem Volume: 141 Page(s): 106923
    12/01/2023 Authors: Amblard F; Chen Z; Wiseman J; Zhou S; Liu P; Salman M; Verma K; Azadi N; Downs-Bowen J; Tao S
  • Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages.
    J Biol Chem Volume: 299 Page(s): 104984
    08/01/2023 Authors: Bowen NE; Tao S; Cho Y-J; Schinazi RF; Kim B
  • Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial.
    J Intern Med Volume: 292 Page(s): 925 - 940
    12/01/2022 Authors: Jdersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzn S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G
  • Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice.
    Microorganisms Volume: 10
    10/22/2022 Authors: LeCher JC; Zandi K; Costa VV; Amblard F; Tao S; Patel D; Lee S; da Silva Santos FR; Goncalves MR; Queroz-Junior CM
  • Pharmacokinetics of Ruxolitinib in HIV Suppressed Individuals on Antiretroviral Agent Therapy from the ACTG A5336 Study.
    J Clin Pharmacol Volume: 61 Page(s): 1555 - 1566
    12/01/2021 Authors: Hurwitz SJ; Tao S; Gavegnano C; Jiang Y; Tressler RL; Tsibris A; Del Rio C; Overton ET; Lederman MM; Kantor A
  • Disproportionate presence of adenosine in mitochondrial and chloroplast DNA of Chlamydomonas reinhardtii.
    iScience Volume: 24 Page(s): 102005
    01/22/2021 Authors: El-Sayed WMM; Gombolay AL; Xu P; Yang T; Jeon Y; Balachander S; Newnam G; Tao S; Bowen NE; Brna T
  • Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
    Cell Volume: 184 Page(s): 460 - 475.e21
    01/21/2021 Authors: Hoang TN; Pino M; Boddapati AK; Viox EG; Starke CE; Upadhyay AA; Gumber S; Nekorchuk M; Busman-Sahay K; Strongin Z
  • Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator.
    Viruses Volume: 13
    01/15/2021 Authors: Hurwitz SJ; McBrearty N; Arzumanyan A; Bichenkov E; Tao S; Bassit L; Chen Z; Kohler JJ; Amblard F; Feitelson MA
  • Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
    Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
    01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ
  • Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
    bioRxiv
    09/16/2020 Authors: Hoang TN; Pino M; Boddapati AK; Viox EG; Starke CE; Upadhyay AA; Gumber S; Busman-Sahay K; Strongin Z; Harper JL
  • Erratum for Amblard et al., "Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice".
    Antimicrob Agents Chemother Volume: 64
    08/20/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
  • Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine.
    Nat Commun Volume: 11 Page(s): 2447
    05/15/2020 Authors: Balachander S; Gombolay AL; Yang T; Xu P; Newnam G; Keskin H; El-Sayed WMM; Bryksin AV; Tao S; Bowen NE
  • The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression.
    Transl Oncol Volume: 13 Page(s): 100751
    04/01/2020 Authors: Li Z; Sun C; Tao S; Osunkoya AO; Arnold RS; Petros JA; Zu X; Moreno CS
  • Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
    EMBO Mol Med Volume: 12 Page(s): e10419
    03/06/2020 Authors: Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CB; Sandhow L; Kutzner J; Hed Myrberg I; Bunten SS; Axelsson H; Zhang SM
  • Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.
    Antimicrob Agents Chemother Volume: 64
    01/27/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O
  • Intracellular metabolism and potential cardiotoxicity of a -D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.
    Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 204 - 224
    01/01/2020 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Ehteshami M; Jiang Y; Amblard F; Coats SJ
  • Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro.
    J Neuroinflammation Volume: 16 Page(s): 182
    09/27/2019 Authors: Gavegnano C; Haile WB; Hurwitz S; Tao S; Jiang Y; Schinazi RF; Tyor WR
  • Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
    Antimicrob Agents Chemother Volume: 63
    09/01/2019 Authors: Zandi K; Amblard F; Amichai S; Bassit L; Tao S; Jiang Y; Zhou L; Ollinger Russell O; Mengshetti S; Schinazi RF
  • Discovery of a Series of 2'--Fluoro,2'--bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
    J Med Chem Volume: 62 Page(s): 1859 - 1874
    02/28/2019 Authors: Mengshetti S; Zhou L; Sari O; De Schutter C; Zhang H; Cho JH; Tao S; Bassit LC; Verma K; Domaoal RA
  • Long-term virological and adherence outcomes to antiviral treatment in a 4-year cohort chronic HBV study.
    Antivir Ther Volume: 24 Page(s): 567 - 579
    01/01/2019 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Ferreira AS; Hori PC; Ganova-Raeva LM; Khudyakov Y; Schinazi RF; Carrilho FJ
  • Disparate effects of cytotoxic chemotherapy on the antiviral activity of antiretroviral therapy: implications for treatments of HIV-infected cancer patients.
    Antivir Ther Volume: 24 Page(s): 177 - 186
    01/01/2019 Authors: Medina-Moreno S; Zapata JC; Cottrell ML; Le NM; Tao S; Bryant J; Sausville E; Schinazi RF; Kashuba AD; Redfield RR
  • Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex.
    Nucleic Acids Res Volume: 46 Page(s): 9711 - 9725
    10/12/2018 Authors: Handa S; Jiang Y; Tao S; Foreman R; Schinazi RF; Miller JF; Ghosh P
  • HIV transmission in discordant couples in Africa in the context of antiretroviral therapy availability.
    AIDS Volume: 32 Page(s): 1613 - 1623
    07/31/2018 Authors: Woodson E; Goldberg A; Michelo C; Basu D; Tao S; Schinazi R; Jiang Y; Kilembe W; Karita E; Allen S
  • Baricitinib Reverses HIV Associated Neurocognitive Disorders in a SCID Murine Model
    Volume: 24 Page(s): S29 - S29
    04/01/2018 Authors: Gavegnano C; Haile W; Koneru R; Tao S; Hurwitz S; Schinazi R; Tyor W
  • Baricitinib Reverses HIV Associated Neurocognitive Disorders in a SCID Murine Model
    Volume: 13 Page(s): S29 - S29
    04/01/2018 Authors: Gavegnano C; Haile W; Koneru R; Tao S; Hurwitz S; Schinazi R; Tyor W
  • 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
    J Med Chem Volume: 60 Page(s): 5424 - 5437
    07/13/2017 Authors: Zhou S; Mahmoud S; Liu P; Zhou L; Ehteshami M; Bassit L; Tao S; Domaoal RA; Sari O; Schutter CD
  • Pharmacokinetics and Placental Transfer of Elvitegravir, Dolutegravir, and Other Antiretrovirals during Pregnancy.
    Antimicrob Agents Chemother Volume: 61
    06/01/2017 Authors: Rimawi BH; Johnson E; Rajakumar A; Tao S; Jiang Y; Gillespie S; Schinazi RF; Mirochnick M; Badell ML; Chakraborty R
  • Characterization of -d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
    Antimicrob Agents Chemother Volume: 61
    04/01/2017 Authors: Ehteshami M; Tao S; Zandi K; Hsiao H-M; Jiang Y; Hammond E; Amblard F; Russell OO; Merits A; Schinazi RF
  • Substrates and Inhibitors of SAMHD1.
    PLoS One Volume: 12 Page(s): e0169052
    01/01/2017 Authors: Hollenbaugh JA; Shelton J; Tao S; Amiralaei S; Liu P; Lu X; Goetze RW; Zhou L; Nettles JH; Schinazi RF
  • Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study.
    Lancet Gastroenterol Hepatol Volume: 1 Page(s): 97 - 104
    10/01/2016 Authors: Lau G; Benhamou Y; Chen G; Li J; Shao Q; Ji D; Li F; Li B; Liu J; Hou J
  • Semi-quantitative Detection of HIV-1 RNA in Plasma Using an In-house RT-PCR Technique for Monitoring Self-reported Antiretroviral Treatment Adherence
    Volume: 32 Page(s): 409 - 409
    10/01/2016 Authors: Michelo C; Sharkey T; Mfune T; Basu D; Tao S; Jiang Y; Schinazi R; Kilembe W; Allen S; Hunter E
  • Acute HIV-1 Transmission in Zambian Couples in the Post-HAART Era: Treatment Failure or Lack of Adherence?
    Volume: 32 Page(s): 257 - 257
    10/01/2016 Authors: Woodson E; Basu D; Goldberg A; Kilembe W; Inambao M; Tao S; Schinazi R; Hunter E; Allen S
  • Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
    Antimicrob Agents Chemother Volume: 60 Page(s): 4659 - 4669
    08/01/2016 Authors: Ehteshami M; Tao S; Ozturk T; Zhou L; Cho JH; Zhang H; Amiralaei S; Shelton JR; Lu X; Khalil A
  • The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model.
    Neurobiol Dis Volume: 92 Page(s): 137 - 143
    08/01/2016 Authors: Haile WB; Gavegnano C; Tao S; Jiang Y; Schinazi RF; Tyor WR
  • Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.
    ACS Med Chem Lett Volume: 7 Page(s): 17 - 22
    01/14/2016 Authors: Zhou L; Zhang H; Tao S; Ehteshami M; Cho JH; McBrayer TR; Tharnish P; Whitaker T; Amblard F; Coats SJ
  • Four years real-life experience with antiviral adherence in chronic hepatitis B infection in a tertiary university hospital
    Volume: 62 Page(s): 963A - 963A
    10/01/2015 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Paranagua-Vezozzo D; Schinazi RF; Carrilho FJ; Ono SK
  • Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
    Bioorg Med Chem Lett Volume: 25 Page(s): 3711 - 3715
    09/01/2015 Authors: Boucle S; Tao S; Amblard F; Stanton RA; Nettles JH; Li C; McBrayer TR; Whitaker T; Coats SJ; Schinazi RF
  • Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients.
    AIDS Volume: 29 Page(s): 1113 - 1115
    06/01/2015 Authors: Lahiri CD; Tao S; Jiang Y; Sheth AN; Acosta EP; Marconi VC; Armstrong WS; Schinazi RF; Vunnava A; Sanford S
  • -D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
    J Med Chem Volume: 58 Page(s): 3445 - 3458
    04/23/2015 Authors: Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Pradere U; Cho JH
  • Nonlinear dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
    PURINERGIC SIGNALLING Volume: 10 Page(s): 696 - 696
    12/01/2014 Authors: Hollenbaugh JA; Tao S; Lenzi G; Ryu S; Kim D-H; Schinazi RF; Kim B
  • Lack of Awareness of Human Immunodeficiency Virus (HIV) Infection: Problems and Solutions With Self-reported HIV Serostatus of Men Who Have Sex With Men.
    Open Forum Infect Dis Volume: 1 Page(s): ofu084
    09/01/2014 Authors: Sanchez TH; Kelley CF; Rosenberg E; Luisi N; O'Hara B; Lambert R; Coleman R; Frew P; Salazar LF; Tao S
  • dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.
    Retrovirology Volume: 11 Page(s): 63
    08/27/2014 Authors: Hollenbaugh JA; Tao S; Lenzi GM; Ryu S; Kim D-H; Diaz-Griffero F; Schinazi RF; Kim B
  • Enhanced antiretroviral therapy in rhesus macaques improves RT-SHIV viral decay kinetics.
    Antimicrob Agents Chemother Volume: 58 Page(s): 3927 - 3933
    07/01/2014 Authors: North TW; Villalobos A; Hurwitz SJ; Deere JD; Higgins J; Chatterjee P; Tao S; Kauffman RC; Luciw PA; Kohler JJ
  • Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women.
    Antimicrob Agents Chemother Volume: 58 Page(s): 4014 - 4019
    07/01/2014 Authors: Geisler WM; Pascual MLG; Mathew J; Koltun WD; Morgan F; Batteiger BE; Mayes A; Tao S; Hurwitz SJ; Sayada C
  • Comparison of Three 2 '-C-Methyl Guanosine Prodrugs for Hepatitis C including a Novel beta-D-2 '-C-Me-2,6-Diaminopurine Ribonucleoside Phosphoramidate (RS-1389): Interspecies Hepatocyte and Human Cardiomyocyte Metabolism Profiles
    Volume: 60 Page(s): 1170A - 1171A
    01/01/2014 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Coats SJ; Schinazi RF
  • A 4-N-Hydroxycytidine Ribonucleoside Phosphoramidate Delivers Intracellularly Three Distinct Active 5 '-Triphosphate Nucleosides that are Potent Inhibitors of HCV Polymerase
    Volume: 60 Page(s): 1162A - 1162A
    01/01/2014 Authors: Schinazi RF; Amblard F; Tao S; Ehteshami M; Amiralaei S; Li H; Shelton J; Whitaker T; McBrayer TR; Coats SJ
  • Phosphoramidate Prodrugs of beta-D-2 '-C-Me-2,6-diaminopurine Ribonucleoside are Potent Inhibitors of Hepatitis C Virus (HCV) Replication Delivering Two Active Nucleoside Triphosphates
    Volume: 58 Page(s): 437A - 437A
    10/01/2013 Authors: Schinazi RF; Zhou L; Zhang H; Ehteshami M; Tao S; Bassit LC; Suesserman J; Whitaker T; McBrayer TR; Cho J-H
  • Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.
    ACS Med Chem Lett Volume: 4 Page(s): 747 - 751
    08/08/2013 Authors: Bondada L; Detorio M; Bassit L; Tao S; Montero CM; Singletary TM; Zhang H; Zhou L; Cho J-H; Coats SJ
  • NOVEL EFFECTOR OF HBV CAPSID ASSEMBLY REDUCES THE ACTIVITY OF cccDNA AND INTERACTS SYNERGISTICALLY WITH NUCLEOSIDE ANALOGS IN THE HUMAN HEPATOCYTES
    Volume: 58 Page(s): S298 - S299
    04/01/2013 Authors: Bassit L; Ozturk T; Tao S; Boucle SR; Ehteshami M; Zlotnick A; Feitelson MA; Schinazi RF
  • beta-D-2 '-C-Me-2,6-diaminopurine ribonucleoside phosphoramidates are potent and selective inhibitors of hepatitis C virus (HCV) and are bioconverted intracellularly to bioactive 2,6-diaminopurine- and guanosine-5 '-triphosphate forms
    Volume: 18 Page(s): A57 - A57
    01/01/2013 Authors: Schinazi RF; Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Detorio M
  • Biochemical characterization of beta-D-2 '-C-methyl-2,6-diaminopurine-ribonucleoside-5 '-triphosphate as a potent inhibitor of hepatitis C virus (HCV) polymerase
    Volume: 18 Page(s): A10 - A10
    01/01/2013 Authors: Ehteshami M; Amiralaei S; Shelton JR; Tao S; Suesserman JE; Zhang H-W; Zhou L; Coats SJ; Schinazi RF
  • Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
    Drug Metab Dispos Volume: 40 Page(s): 2307 - 2314
    12/01/2012 Authors: Cheng C; Yang M; Yu K; Guan S; Tao S; Millar A; Pang X; Guo D
  • Synthesis and evaluation of novel potent HCV NS5A inhibitors.
    Bioorg Med Chem Lett Volume: 22 Page(s): 4864 - 4868
    07/15/2012 Authors: Zhang H; Zhou L; Amblard F; Shi J; Bobeck DR; Tao S; McBrayer TR; Tharnish PM; Whitaker T; Coats SJ
  • Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
    Eur J Med Chem Volume: 46 Page(s): 3832 - 3844
    09/01/2011 Authors: Zhang H-W; Detorio M; Herman BD; Solomon S; Bassit L; Nettles JH; Obikhod A; Tao S-J; Mellors JW; Sluis-Cremer N
  • Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans.
    Antivir Ther Volume: 16 Page(s): 1123 - 1130
    01/01/2011 Authors: van Maarseveen NM; Wensing AM; de Jong D; Beilhartz GL; Obikhod A; Tao S; Pingen M; Arends JE; Hoepelman AI; Schinazi RF
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