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Profile

Stacey Smith

  • Department of Medicine
    Assistant Professor
  • stacey.abigail.smith@emory.edu
Head shot of Stacey Smith

Overview

My primary research expertise encompasses HIV/SIV evolution, transmission, vaccination, and functional cure within human and non-human primate models. My current research focuses on defining the microbial and immunological environment of the gut in regards to HIV transmission and replication, in a sex- and gender-inclusive manner.

Academic Appointment

  • Laboratory Director for the Emory HIV/AIDS Clinical Trials Unit (CTU) Infectious Disease Clinical Research Lab (EIDCRL) & Emory Center for AIDS Research (CFAR) Clinical Core combined laboratories, Emory University
  • Assistant Professor of Medicine, Emory University

Education

Degrees

  • PhD from University of Oklahoma Health Sciences Center

Research

Publications

  • Rectal mucosal inflammation, microbiome, and wound healing in men who have sex with men who engage in receptive anal intercourse.
    Sci Rep Volume: 14 Page(s): 31598
    12/30/2024 Authors: Van Doren VE; Ackerley CG; Arthur RA; Murray PM; Smith SA; Hu Y-J; Kelley CF
  • Integrated analysis of rectal mucosal microbiome and transcriptome reveals a distinct microenvironment among young MSM.
    JCI Insight Volume: 9
    11/08/2024 Authors: Ackerley CG; Smith SA; Murray PM; Amancha PK; Van Doren VE; Tharp GK; Arthur RA; Amara RR; Hu Y-J; Kelley CF
  • Pain mechanisms in the transgender individual: a review.
    Front Pain Res (Lausanne) Volume: 5 Page(s): 1241015
    01/01/2024 Authors: Anger JT; Case LK; Baranowski AP; Berger A; Craft RM; Damitz LA; Gabriel R; Harrison T; Kaptein K; Lee S
  • HIV, asymptomatic STI, and the rectal mucosal immune environment among young men who have sex with men.
    PLoS Pathog Volume: 19 Page(s): e1011219
    05/01/2023 Authors: Van Doren VE; Smith SA; Hu Y-J; Tharp G; Bosinger S; Ackerley CG; Murray PM; Amara RR; Amancha PK; Arthur RA
  • T-cell activation and B-cell interaction signatures in rectal tissues are associated with HIV replication in ex-vivo model of infection.
    AIDS Volume: 36 Page(s): 2101 - 2106
    12/01/2022 Authors: Smith SA; Murray PM; Amancha PK; Ackerley CG; Tharp GK; Bosinger SE; Amara RR; Kelley CF
  • Early neutralizing antibodies elicited in HIV-1 infection can be recapitulated in rhesus macaques immunized with patient T/F envelope sequences
    Volume: 51 Page(s): 305 - 306
    10/01/2022 Authors: Welbourn S; Charles T; Burton S; Chakraborty S; Yang J; Gleinich A; Khan S; Smith SA; Gangadhara S; Yagnik B
  • A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.
    PLoS Pathog Volume: 18 Page(s): e1010488
    05/01/2022 Authors: Welbourn S; Chakraborty S; Yang JE; Gleinich AS; Gangadhara S; Khan S; Ferrebee C; Yagnik B; Burton S; Charles T
  • The rectal mucosal immune environment and HIV susceptibility among young men who have sex with men.
    Front Immunol Volume: 13 Page(s): 972170
    01/01/2022 Authors: Ackerley CG; Smith SA; Murray PM; Amancha PK; Arthur RA; Zhu Z; Chahroudi A; Amara RR; Hu Y-J; Kelley CF
  • Disruption of immune cell homeostasis within rectal mucosal tissue of HIV plus young men who have sex with men
    Volume: 24
    02/01/2021 Authors: Smith SA; Amancha PK; Murray PM; Pollack IR; Ackerley CG; Amara RR; Kelley CF
  • Ex vivo rectal explant model reveals potential opposing roles of Natural Killer cells and Marginal Zone-like B cells in HIV-1 infection.
    Sci Rep Volume: 10 Page(s): 20154
    11/19/2020 Authors: Smith SA; Murray PM; Amancha PK; Ackerley CG; Hu Y-J; Amara RR; Kelley CF
  • Short Communication:Transgender Women on Feminizing Hormone Therapy Demonstrate a Distinct Rectal Mucosal Transcriptome from Cisgender Men.
    AIDS Res Hum Retroviruses Volume: 36 Page(s): 771 - 774
    09/01/2020 Authors: Ackerley CG; Billingsley JM; Tharp GK; Amancha PK; Tangpricha V; Smith SA; Amara R; Bosinger SE; Kelley CF
  • Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
    Nature Volume: 578 Page(s): 154 - 159
    02/01/2020 Authors: McBrien JB; Mavigner M; Franchitti L; Smith SA; White E; Tharp GK; Walum H; Busman-Sahay K; Aguilera-Sandoval CR; Thayer WO
  • Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
    Nature Volume: 578 Page(s): E21
    02/01/2020 Authors: McBrien JB; Mavigner M; Franchitti L; Smith SA; White E; Tharp GK; Walum H; Busman-Sahay K; Aguilera-Sandoval CR; Thayer WO
  • Characterization of vaccine-induced antibody responses
    Volume: 47 Page(s): 331 - 331
    10/01/2018 Authors: Charles T; Burton S; Spicer L; Smith SA; Styles T; Reddy P; Legere T; Velu V; Amara R; Derdeyn C
  • Early Antibodies Against the Transmitted/Founder HIV-1 Envelope gp120 Are Dominated by the Immunoglobulin Heavy Chain Germline VH1-69
    Volume: 34 Page(s): 77 - 77
    10/01/2018 Authors: Smith SA; Burton S; Kilembe W; Lakhi S; Karita E; Price M; Allen S; Derdeyn C
  • VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted/Founder gp120.
    Front Immunol Volume: 9 Page(s): 3163
    01/01/2018 Authors: Smith SA; Burton SL; Kilembe W; Lakhi S; Karita E; Price M; Allen S; Derdeyn CA
  • New Connections: Cell-to-Cell HIV-1 Transmission, Resistance to Broadly Neutralizing Antibodies, and an Envelope Sorting Motif.
    J Virol Volume: 91
    05/01/2017 Authors: Smith SA; Derdeyn CA
  • Characterization of the Early Antibody Landscape In HIV-1 Infected Individuals Who Develop Poor to Elite Levels of Neutralization Breadth
    Volume: 74 Page(s): 77 - 77
    03/01/2017 Authors: Smith SA; Burton S; Kilembe W; Lakhi S; Karita E; Price M; Allen S; Hunter E; Derdeyn C
  • Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth.
    PLoS Pathog Volume: 12 Page(s): e1005989
    11/01/2016 Authors: Smith SA; Burton SL; Kilembe W; Lakhi S; Karita E; Price M; Allen S; Hunter E; Derdeyn CA
  • Characterization of the Early Antibody Landscape in HIV-1 Infected Individuals Who Develop Poor to Elite Levels of Neutralization Breadth
    Volume: 32 Page(s): 60 - 60
    10/01/2016 Authors: Smith SA; Burton S; Kilgore K; Kilembe W; Lakhi S; Karita E; Price M; Allen S; Hunter E; Derdeyn C
  • CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.
    Immunity Volume: 45 Page(s): 656 - 668
    09/20/2016 Authors: Cartwright EK; Spicer L; Smith SA; Lee D; Fast R; Paganini S; Lawson BO; Nega M; Easley K; Schmitz JE
  • Signatures in Simian Immunodeficiency Virus SIVsmE660 Envelope gp120 Are Associated with Mucosal Transmission but Not Vaccination Breakthrough in Rhesus Macaques.
    J Virol Volume: 90 Page(s): 1880 - 1887
    02/15/2016 Authors: Smith SA; Kilgore KM; Kasturi SP; Pulendran B; Hunter E; Amara RR; Derdeyn CA
  • Harnessing the protective potential of HIV-1 neutralizing antibodies.
    F1000Res Volume: 5
    01/01/2016 Authors: Smith SA; Derdeyn CA
  • A pathway to HIV-1 neutralization breadth.
    Nat Med Volume: 21 Page(s): 1246 - 1247
    11/01/2015 Authors: Smith SA; Derdeyn CA
  • Breakthrough of SIV strain smE660 challenge in SIV strain mac239-vaccinated rhesus macaques despite potent autologous neutralizing antibody responses.
    Proc Natl Acad Sci U S A Volume: 112 Page(s): 10780 - 10785
    08/25/2015 Authors: Burton SL; Kilgore KM; Smith SA; Reddy S; Hunter E; Robinson HL; Silvestri G; Amara RR; Derdeyn CA
  • Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.
    J Virol Volume: 89 Page(s): 8130 - 8151
    08/01/2015 Authors: Kilgore KM; Murphy MK; Burton SL; Wetzel KS; Smith SA; Xiao P; Reddy S; Francella N; Sodora DL; Silvestri G
  • DNA/MVA and Protein-based SIV Vaccine Regimens Delivered to Rhesus Macaques with Novel Adjuvants Fail to Elicit Neutralizing Antibodies with Breadth.
    AIDS Res Hum Retroviruses Volume: 30 Suppl 1 Page(s): A84
    10/01/2014 Authors: Murphy MK; Wetzel KS; Kilgore KM; Smith SA; Burton SL; Reddy S; Francella N; Sodora DL; Silvestri G; Cole KS
  • SIVsmE660 Envelope Variants from Breakthrough Infections Following DNA/MVA Vaccination of Rhesus Macaques Are Susceptible to Neutralization.
    AIDS Res Hum Retroviruses Volume: 30 Suppl 1 Page(s): A26
    10/01/2014 Authors: Smith SA; Burton S; Reddy S; Kilgore K; Hunter E; Robinson H; Amara R; Derdeyn C
  • HIV-1 Env C2-V4 diversification in a slow-progressor infant reveals a flat but rugged fitness landscape.
    PLoS One Volume: 8 Page(s): e63094
    01/01/2013 Authors: Smith SA; Wood C; West JT
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