Sheikh Rahman
- Department of Pathology and Laboratory Medicine
Assistant Professor
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Whitehead Biomedical Research Building
First Floor, Room 142
615 Michael Street
Overview
Dr. Rahman is an infectious disease researcher with a specific interest in Human Immunodeficiency Virus (HIV). During his Ph.D. at the Ruprecht Karl University of Heidelberg, Germany, and then as a Visiting Fellow at the National Institutes of Health, USA, Dr. Rahman studied HIV biogenesis and lentiviral genome packaging mechanisms. These studies resulted in significant contributions to the field of HIV virology. As a postdoctoral fellow and then as a junior faculty at the Emory National Primate Research Center, Dr. Rahman studied HIV pathogenesis and cure strategies using the non-human primate model. Here, Dr. Rahman investigated vaccine and immunotherapeutic approaches towards achieving a functional HIV cure. These studies resulted in high-impact publications. In addition, Dr. Rahman studied vaccine development for other infectious agents such as SARS-CoV-2 and Hepatitis C Virus using mouse and NHP animal models. Using funding support from the Emory Center for AIDS Research, Dr. Rahman developed a novel 3D organoid model that can efficiently support HIV and SIV infections. Dr. Rahman is exploiting this system to study HIV pathogenesis, latency establishment mechanisms, as well as cure strategies. Through his research, Dr. Rahman has developed extensive expertise in the field of HIV virology, immunology, vaccinology, and therapeutic approaches that utilize techniques such as multi-panel flow cytometry, immunohistochemistry, RNASeq, organoid and cell culture, live cell imaging, molecular and biochemical techniques such as vector designing, cloning, and antigen-specific T and B cell immunological assays. Dr. Rahman is using cutting-edge approaches to push the boundaries of HIV research that can lead to a successful cure.
Academic Appointment
- Affiliate Scientist, Division of Microbiology and Immunology, Emory University
- Affiliate Scientist, Emory National Primate Research Center, Emory University
- Assistant Professor, Pathology and Laboratory Medicine, Emory University School of Medicine
Education
Degrees
- PhD from Ruprecht Karl University of Heidelberg
- MS from Himachal Pradesh University
- BS from Jamia Millia Islamia
Research
Publications
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A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection.
Sci Immunol Volume: 7 Page(s): eabo0226
06/24/2022 Authors: Routhu NK; Gangadhara S; Lai L; Davis-Gardner ME; Floyd K; Shiferaw A; Bartsch YC; Fischinger S; Khoury G; Rahman SA -
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection.
JCI Insight Volume: 7
04/22/2022 Authors: Rahman SA; Billingsley JM; Sharma AA; Styles TM; Govindaraj S; Shanmugasundaram U; Babu H; Riberio SP; Ali SA; Tharp GK -
Editorial: Decoding the genetics of viral evolution.
Front Genet Volume: 13 Page(s): 978485
01/01/2022 Authors: Ali H; Rahman SA; Akhtar J; Haque SA; Ali S -
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8+ T cells in lymphoid tissue.
Sci Immunol Volume: 6 Page(s): eabh3034
09/10/2021 Authors: Rahman SA; Yagnik B; Bally AP; Morrow KN; Wang S; Vanderford TH; Freeman GJ; Ahmed R; Amara RR -
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
Immunity Volume: 54 Page(s): 542 - 556.e9
03/09/2021 Authors: Routhu NK; Cheedarla N; Gangadhara S; Bollimpelli VS; Boddapati AK; Shiferaw A; Rahman SA; Sahoo A; Edara VV; Lai L -
Investigating Virological, Immunological, and Pathological Avenues to Identify Potential Targets for Developing COVID-19 Treatment and Prevention Strategies.
Vaccines (Basel) Volume: 8
08/06/2020 Authors: Mahmood Z; Alrefai H; Hetta HF; A Kader H; Munawar N; Abdul Rahman S; Elshaer S; Batiha GE-S; Muhammad K -
HIV-1 Sequence Necessary and Sufficient to Package Non-viral RNAs into HIV-1 Particles.
J Mol Biol Volume: 429 Page(s): 2542 - 2555
08/04/2017 Authors: Liu Y; Nikolaitchik OA; Rahman SA; Chen J; Pathak VK; Hu W-S -
HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein.
Proc Natl Acad Sci U S A Volume: 113 Page(s): E201 - E208
01/12/2016 Authors: Chen J; Rahman SA; Nikolaitchik OA; Grunwald D; Sardo L; Burdick RC; Plisov S; Liang E; Tai S; Pathak VK -
Investigating the role of F-actin in human immunodeficiency virus assembly by live-cell microscopy.
J Virol Volume: 88 Page(s): 7904 - 7914
07/01/2014 Authors: Rahman SA; Koch P; Weichsel J; Godinez WJ; Schwarz U; Rohr K; Lamb DC; Krusslich H-G; Mller B -
The nucleocapsid domain of Gag is dispensable for actin incorporation into HIV-1 and for association of viral budding sites with cortical F-actin.
J Virol Volume: 88 Page(s): 7893 - 7903
07/01/2014 Authors: Stauffer S; Rahman SA; de Marco A; Carlson L-A; Glass B; Oberwinkler H; Herold N; Briggs JAG; Mller B; Grnewald K