Shan Ping Yu MD, PhD

Department of Anesthesiology
Professor

Emory University School of Medicine
Anesthesiology
101 Woodruff Circle, Suite 620B

Overview

Dr. Yu is the Asa Griggs Candler Endowed Professor in the Department of Anesthesiology and the Department of Hematology/Oncology. He is an expert in the investigation of cellular and molecular mechanisms of neuronal cell death, regeneration and stem cell transplantation therapy. His research includes the development of novel treatments for stroke, cancer, and pain. He has served in NIH and AHA study sections for several terms and in editorial boards of several national and international journals.

Academic Appointment

Professor of Anesthesiology, Hematology and Ocology, Department of Anesthesiology, Department of Hematology and Oncology, Emory University School of Medicine

Education

Degrees

PhD from State University of New York at Stony Brook
MD & MS from Capital Institute of Medicine, Institute of Pharmacology & Toxicology

Research

Focus

My research has been focused on ionic and molecular mechanisms underlying cell death and neurodegeneration related to brain disorders and cancer pain regulation. Specifically, we are interested in apoptotic regulation of potassium channels, NMDA receptor channels and Na+,K+-ATPase in neuronal and cancer cells. In this regard, we have been investigating the roles of channels/receptors in cell differentiation, migration, pain sensation, and have integrated our research into stem cell therapy for CNS and PNS injuries.

Publications

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease.
Neural Regen Res Volume: 20 Page(s): 1981 - 1988
07/01/2025 Authors: Yu SP; Choi E; Jiang MQ; Wei L
Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy.
Cells Volume: 13
05/23/2024 Authors: Jiang MQ; Yu SP; Estaba T; Choi E; Berglund K; Gu X; Wei L
FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBP/-secretase in female mice.
Nat Commun Volume: 14 Page(s): 6577
10/18/2023 Authors: Xiong J; Kang SS; Wang M; Wang Z; Xia Y; Liao J; Liu X; Yu S-P; Zhang Z; Ryu V
Strain hypothesis and additional evidence of the GluN3A deficiency-mediated pathogenesis of Alzheimer's disease.
Alzheimers Dement Volume: 19 Page(s): 4267 - 4269
09/01/2023 Authors: Yu SP; Jiang M; Berglund K; Wei L
Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease.
Mol Neurodegener Volume: 18 Page(s): 43
07/03/2023 Authors: Yu SP; Jiang MQ; Shim SS; Pourkhodadad S; Wei L
Hypoxia-Preconditioned Bone Marrow Mesenchymal Stem Cells Improved Cerebral Collateral Circulation and Stroke Outcome in Mice.
Arterioscler Thromb Vasc Biol Volume: 43 Page(s): 1281 - 1294
07/01/2023 Authors: Tian H; Yang X; Zhao J; Liu X; Liu X; Cai Y; Wehbe A; Ding Y; Yu S; Wei L
Neuroprotection of Low-Frequency Repetitive Transcranial Magnetic Stimulation after Ischemic Stroke in Rats.
Ann Neurol Volume: 93 Page(s): 336 - 347
02/01/2023 Authors: Buetefisch CM; Wei L; Gu X; Epstein CM; Yu SP
Lithium: An Old Drug for New Therapeutic Strategy for Alzheimer's Disease and Related Dementia.
Neurodegener Dis Volume: 23 Page(s): 1 - 12
01/01/2023 Authors: Shim SS; Berglund K; Yu SP
Glycosaminoglycan scaffolding and neural progenitor cell transplantation promotes regenerative immunomodulation in the mouse ischemic brain.
Exp Neurol Volume: 357 Page(s): 114177
11/01/2022 Authors: McCrary MR; Jiang MQ; Jesson K; Gu X; Logun MT; Wu A; Gonsalves N; Karumbaiah L; Yu SP; Wei L
PREVENTIVE MEMANTINE TREATMENT FOR THE COMORBIDITY OF STROKE AND ALZHEIMER'S DISEASE
Volume: 17 Page(s): 12 - 12
10/01/2022 Authors: Gu X; Jiang M; Lin T; Shah N; Wei L; Yu SP
C/EBP/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer's disease.
Mol Psychiatry Volume: 27 Page(s): 3034 - 3046
07/01/2022 Authors: Liao J; Chen G; Liu X; Wei ZZ; Yu SP; Chen Q; Ye K
Neuronal C/EBP/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression.
Sci Adv Volume: 8 Page(s): eabj8658
04/01/2022 Authors: Xia Y; Qadota H; Wang Z-H; Liu P; Liu X; Ye KX; Matheny CJ; Berglund K; Yu SP; Drake D
FSH blockade improves cognition in mice with Alzheimer's disease.
Nature Volume: 603 Page(s): 470 - 476
03/01/2022 Authors: Xiong J; Kang SS; Wang Z; Liu X; Kuo T-C; Korkmaz F; Padilla A; Miyashita S; Chan P; Zhang Z
Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A.
Alzheimers Dement Volume: 18 Page(s): 222 - 239
02/01/2022 Authors: Zhong W; Wu A; Berglund K; Gu X; Jiang MQ; Talati J; Zhao J; Wei L; Yu SP
Neuronal ApoE4 stimulates C/EBP activation, promoting Alzheimer's disease pathology in a mouse model.
Prog Neurobiol Volume: 209 Page(s): 102212
02/01/2022 Authors: Wang Z-H; Xia Y; Wu Z; Kang SS; Zhang J-C; Liu P; Liu X; Song W; Huin V; Dhaenens C-M
Tuning Protein Dynamics to Sense Rapid Endoplasmic-Reticulum Calcium Dynamics.
Angew Chem Int Ed Engl Volume: 60 Page(s): 23289 - 23298
10/18/2021 Authors: Deng X; Yao X-Q; Berglund K; Dong B; Ouedraogo D; Ghane MA; Zhuo Y; McBean C; Wei ZZ; Gozem S
C/EBP is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease.
Mol Psychiatry Volume: 26 Page(s): 6002 - 6022
10/01/2021 Authors: Xia Y; Wang Z-H; Zhang J; Liu X; Yu SP; Ye KX; Wang J-Z; Ye K; Wang X-C
DL-3-n-butylphthalide Increases Collateriogenesis and Functional Recovery after Focal Ischemic Stroke in Mice.
Aging Dis Volume: 12 Page(s): 1835 - 1849
10/01/2021 Authors: Wei ZZ; Chen D; Lee MJH; Zhao Y; Gu X; Yu SP; Wei L
Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease.
Prog Neurobiol Volume: 204 Page(s): 102113
09/01/2021 Authors: Xia Y; Wang Z-H; Zhang Z; Liu X; Yu SP; Wang J-Z; Wang X-C; Ye K
GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke.
Exp Neurol Volume: 342 Page(s): 113719
08/01/2021 Authors: Owino S; Giddens MM; Jiang JG; Nguyen TT; Shiu FH; Lala T; Gearing M; McCrary MR; Gu X; Wei L
ApoE4 activates C/EBP/-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.
Prog Neurobiol Volume: 202 Page(s): 102032
07/01/2021 Authors: Wang Z-H; Xia Y; Liu P; Liu X; Edgington-Mitchell L; Lei K; Yu SP; Wang X-C; Ye K
Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
Proc Natl Acad Sci U S A Volume: 118
06/22/2021 Authors: Wu Z; Chen C; Kang SS; Liu X; Gu X; Yu SP; Keene CD; Cheng L; Ye K
Systematic Review of Erythropoietin (EPO) for Neuroprotection in Human Studies.
Neurochem Res Volume: 46 Page(s): 732 - 739
04/01/2021 Authors: Hemani S; Lane O; Agarwal S; Yu SP; Woodbury A
-Secretase-cleaved Tau stimulates A production via upregulating STAT1-BACE1 signaling in Alzheimer's disease.
Mol Psychiatry Volume: 26 Page(s): 586 - 603
02/01/2021 Authors: Zhang Z; Li X-G; Wang Z-H; Song M; Yu SP; Kang SS; Liu X; Zhang Z; Xie M; Liu G-P
Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke.
Front Aging Neurosci Volume: 13 Page(s): 612856
01/01/2021 Authors: Jiang MQ; Yu SP; Wei ZZ; Zhong W; Cao W; Gu X; Wu A; McCrary MR; Berglund K; Wei L
DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects.
Neurosci Bull Volume: 36 Page(s): 407 - 418
04/01/2020 Authors: Zhang G; Kim S; Gu X; Yu SP; Wei L
Improved trafficking and expression of luminopsins for more efficient optical and pharmacological control of neuronal activity.
J Neurosci Res Volume: 98 Page(s): 481 - 490
03/01/2020 Authors: Zhang JY; Tung JK; Wang Z; Yu SP; Gross RE; Wei L; Berglund K
Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice.
Exp Neurol Volume: 325 Page(s): 113133
03/01/2020 Authors: Zhao Y; Wei ZZ; Lee JH; Gu X; Sun J; Dix TA; Wei L; Yu SP
Cortical Transplantation of Brain-Mimetic Glycosaminoglycan Scaffolds and Neural Progenitor Cells Promotes Vascular Regeneration and Functional Recovery after Ischemic Stroke in Mice.
Adv Healthc Mater Volume: 9 Page(s): e1900285
03/01/2020 Authors: McCrary MR; Jesson K; Wei ZZ; Logun M; Lenear C; Tan S; Gu X; Jiang MQ; Karumbaiah L; Yu SP
Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.
Prog Neurobiol Volume: 185 Page(s): 101730
02/01/2020 Authors: Wu Z; Wang Z-H; Liu X; Zhang Z; Gu X; Yu SP; Keene CD; Cheng L; Ye K
Neuropsychological Deficits Chronically Developed after Focal Ischemic Stroke and Beneficial Effects of Pharmacological Hypothermia in the Mouse.
Aging Dis Volume: 11 Page(s): 1 - 16
02/01/2020 Authors: Zhong W; Yuan Y; Gu X; Kim SI-Y; Chin R; Loye M; Dix TA; Wei L; Yu SP
Author Correction: C/EBP regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Nat Commun Volume: 10 Page(s): 5452
11/26/2019 Authors: Wang Z-H; Gong K; Liu X; Zhang Z; Sun X; Wei ZZ; Yu SP; Manfredsson FP; Sandoval IM; Johnson PF
Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice.
FASEB J Volume: 33 Page(s): 10680 - 10691
10/01/2019 Authors: McCrary MR; Jiang MQ; Giddens MM; Zhang JY; Owino S; Wei ZZ; Zhong W; Gu X; Xin H; Hall RA
Optochemogenetic Stimulation of Transplanted iPS-NPCs Enhances Neuronal Repair and Functional Recovery after Ischemic Stroke.
J Neurosci Volume: 39 Page(s): 6571 - 6594
08/14/2019 Authors: Yu SP; Tung JK; Wei ZZ; Chen D; Berglund K; Zhong W; Zhang JY; Gu X; Song M; Gross RE
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates -Secretase by Upregulating C/EBP in Alzheimer's Disease.
Cell Rep Volume: 28 Page(s): 655 - 669.e5
07/16/2019 Authors: Wang Z-H; Xiang J; Liu X; Yu SP; Manfredsson FP; Sandoval IM; Wu S; Wang J-Z; Ye K
Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
Proc Natl Acad Sci U S A Volume: 116 Page(s): 9094 - 9102
04/30/2019 Authors: Xiang J; Wang Z-H; Ahn EH; Liu X; Yu S-P; Manfredsson FP; Sandoval IM; Ju G; Wu S; Ye K
Direct Conversion of Astrocytes to Neurons Enhances Neuronal Repair and Functional Recovery after Ischemic Stroke
Volume: 28 Page(s): 472 - 472
04/01/2019 Authors: Jiang M; Yu SP; Wei L
Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity.
Neurosci Bull Volume: 35 Page(s): 4 - 14
02/01/2019 Authors: Du W-J; Hu S; Li X; Zhang P-A; Jiang X; Yu S-P; Xu G-Y
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
J Exp Med Volume: 215 Page(s): 3038 - 3056
12/03/2018 Authors: Wang Z-H; Liu P; Liu X; Yu SP; Wang J-Z; Ye K
Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-d-aspartate receptor GluN3A subunit.
Exp Neurol Volume: 305 Page(s): 1 - 12
07/01/2018 Authors: Lee JH; Zhang JY; Wei ZZ; Yu SP
Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.
Neurotherapeutics Volume: 15 Page(s): 770 - 784
07/01/2018 Authors: Chen D; Wei L; Liu Z-R; Yang JJ; Gu X; Wei ZZ; Liu L-P; Yu SP
Correction to: Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities after Ischemic Stroke in Adult Mice.
Neurotherapeutics Volume: 15 Page(s): 836
07/01/2018 Authors: Chen D; Wei L; Liu Z-R; Yang JJ; Gu X; Wei ZZ; Liu L-P; Yu SP
C/EBP regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Nat Commun Volume: 9 Page(s): 1784
05/03/2018 Authors: Wang Z-H; Gong K; Liu X; Zhang Z; Sun X; Wei ZZ; Yu SP; Manfredsson FP; Sandoval IM; Johnson PF
Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice.
BMC Neurosci Volume: 19 Page(s): 20
04/12/2018 Authors: Chau MJ; Deveau TC; Gu X; Kim YS; Xu Y; Yu SP; Wei L
Enhanced Neurogenesis and Collaterogenesis by Sodium Danshensu Treatment After Focal Cerebral Ischemia in Mice.
Cell Transplant Volume: 27 Page(s): 622 - 636
04/01/2018 Authors: Wei ZZ; Chen D; Liu L-P; Gu X; Zhong W; Zhang Y-B; Wang Y; Yu SP; Wei L
Intranasally Delivered Wnt3a Improves Functional Recovery after Traumatic Brain Injury by Modulating Autophagic, Apoptotic, and Regenerative Pathways in the Mouse Brain.
J Neurotrauma Volume: 35 Page(s): 802 - 813
03/01/2018 Authors: Zhang JY; Lee JH; Gu X; Wei ZZ; Harris MJ; Yu SP; Wei L
Molecular Targets and Natural Compounds in Drug Development for the Treatment of Inflammatory Pain.
Curr Drug Targets Volume: 19 Page(s): 1905 - 1915
01/01/2018 Authors: Woodbury A; McCrary MR; Yu SP
Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.
Exp Cell Res Volume: 361 Page(s): 342 - 352
12/15/2017 Authors: Wei S; Luo C; Yu S; Gao J; Liu C; Wei Z; Zhang Z; Wei L; Yi B
DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice.
Neurochem Int Volume: 111 Page(s): 82 - 92
12/01/2017 Authors: Zhao Y; Lee JH; Chen D; Gu X; Caslin A; Li J; Yu SP; Wei L
Transplantation of iPS cell-derived neural progenitors overexpressing SDF-1 increases regeneration and functional recovery after ischemic stroke.
Oncotarget Volume: 8 Page(s): 97537 - 97553
11/14/2017 Authors: Chau M; Deveau TC; Song M; Wei ZZ; Gu X; Yu SP; Wei L
Priming of the Cells: Hypoxic Preconditioning for Stem Cell Therapy.
Chin Med J (Engl) Volume: 130 Page(s): 2361 - 2374
10/05/2017 Authors: Wei ZZ; Zhu Y-B; Zhang JY; McCrary MR; Wang S; Zhang Y-B; Yu S-P; Wei L
Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke.
Prog Neurobiol Volume: 157 Page(s): 49 - 78
10/01/2017 Authors: Wei L; Wei ZZ; Jiang MQ; Mohamad O; Yu SP
Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Mol Cell Volume: 67 Page(s): 812 - 825.e5
09/07/2017 Authors: Wang Z-H; Liu P; Liu X; Manfredsson FP; Sandoval IM; Yu SP; Wang J-Z; Ye K
Long-term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice.
Brain Pathol Volume: 27 Page(s): 480 - 498
07/01/2017 Authors: Jiang MQ; Zhao Y-Y; Cao W; Wei ZZ; Gu X; Wei L; Yu SP
Longitudinal MRI evaluation of neuroprotective effects of pharmacologically induced hypothermia in experimental ischemic stroke.
Magn Reson Imaging Volume: 40 Page(s): 24 - 30
07/01/2017 Authors: Wang S; Gu X; Paudyal R; Wei L; Dix TA; Yu SP; Zhang X
Optogenetic Stimulation of Transplanted Neural Progenitor Cells Improves Regeneration and Functional Recovery After Ischemic Stroke in Rodents
Volume: 26 Page(s): 730 - 731
05/01/2017 Authors: Wei Z; McCrary M; Yu SP; Wei L
Delayed treatment of 6-Bromoindirubin-3'-oxime stimulates neurogenesis and functional recovery after focal ischemic stroke in mice.
Int J Dev Neurosci Volume: 57 Page(s): 77 - 84
04/01/2017 Authors: Wang L-L; Li J; Gu X; Wei L; Yu SP
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nat Commun Volume: 8 Page(s): 14740
03/27/2017 Authors: Zhang Z; Obianyo O; Dall E; Du Y; Fu H; Liu X; Kang SS; Song M; Yu S-P; Cabrele C
Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke.
Neural Regen Res Volume: 12 Page(s): 341 - 350
03/01/2017 Authors: Lee JH; Zhang J; Yu SP
Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice.
Neurobiol Dis Volume: 98 Page(s): 9 - 24
02/01/2017 Authors: Song M; Yu SP; Mohamad O; Cao W; Wei ZZ; Gu X; Jiang MQ; Wei L
Optogenetic Stimulation of Transplanted Neural Progenitor Cells Improves Regeneration and Functional Recovery After Ischemic Stroke in Rodents
Volume: 26 Page(s): 730 - 731
01/01/2017 Authors: Wei Z; McCrary M; Yu SP; Wei L
Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine -Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity.
Front Pharmacol Volume: 8 Page(s): 696
01/01/2017 Authors: Zhao L; Xiao Y; Weng R-X; Liu X; Zhang P-A; Hu C-Y; Yu SP; Xu G-Y
Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice.
Neurobiol Dis Volume: 96 Page(s): 248 - 260
12/01/2016 Authors: Lee JH; Wei ZZ; Cao W; Won S; Gu X; Winter M; Dix TA; Wei L; Yu SP
Inhibition of cystathionine -synthetase suppresses sodium channel activities of dorsal root ganglion neurons of rats with lumbar disc herniation.
Sci Rep Volume: 6 Page(s): 38188
12/01/2016 Authors: Yan J; Hu S; Zou K; Xu M; Wang Q; Miao X; Yu SP; Xu G-Y
Expression of the NMDA receptor subunit GluN3A (NR3A) in the olfactory system and its regulatory role on olfaction in the adult mouse.
Brain Struct Funct Volume: 221 Page(s): 3259 - 3273
07/01/2016 Authors: Lee JH; Wei L; Deveau TC; Gu X; Yu SP
Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats.
Stroke Volume: 47 Page(s): 1907 - 1913
07/01/2016 Authors: Lee JH; Wei L; Gu X; Won S; Wei ZZ; Dix TA; Yu SP
Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats.
J Neuroinflammation Volume: 13 Page(s): 109
05/16/2016 Authors: Lee JH; Espinera AR; Chen D; Choi K-E; Caslin AY; Won S; Pecoraro V; Xu G-Y; Wei L; Yu SP
Administration of low dose estrogen attenuates persistent inflammation, promotes angiogenesis, and improves locomotor function following chronic spinal cord injury in rats.
J Neurochem Volume: 137 Page(s): 604 - 617
05/01/2016 Authors: Samantaray S; Das A; Matzelle DC; Yu SP; Wei L; Varma A; Ray SK; Banik NL
Administration of low dose estrogen attenuates gliosis and protects neurons in acute spinal cord injury in rats.
J Neurochem Volume: 136 Page(s): 1064 - 1073
03/01/2016 Authors: Samantaray S; Das A; Matzelle DC; Yu SP; Wei L; Varma A; Ray SK; Banik NL
Regeneration after stroke: Stem cell transplantation and trophic factors.
Brain Circ Volume: 2 Page(s): 86 - 94
01/01/2016 Authors: Chau M; Zhang J; Wei L; Yu SP
Non-genetic Purification of Ventricular Cardiomyocytes from Differentiating Embryonic Stem Cells through Molecular Beacons Targeting IRX-4.
Stem Cell Reports Volume: 5 Page(s): 1239 - 1249
12/08/2015 Authors: Ban K; Wile B; Cho K-W; Kim S; Song M-K; Kim SY; Singer J; Syed A; Yu SP; Wagner M
Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders.
J Nat Prod Volume: 78 Page(s): 2531 - 2536
11/25/2015 Authors: Woodbury A; Yu SP; Chen D; Gu X; Lee JH; Zhang J; Espinera A; Garca PS; Wei L
Neurodevelopmental implications of the general anesthesia in neonate and infants.
Exp Neurol Volume: 272 Page(s): 50 - 60
10/01/2015 Authors: Lee JH; Zhang J; Wei L; Yu SP
Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats.
Exp Neurol Volume: 267 Page(s): 135 - 142
05/01/2015 Authors: Gu X; Wei ZZ; Espinera A; Lee JH; Ji X; Wei L; Dix TA; Yu SP
A neuroprotective role of the NMDA receptor subunit GluN3A (NR3A) in ischemic stroke of the adult mouse.
Am J Physiol Cell Physiol Volume: 308 Page(s): C570 - C577
04/01/2015 Authors: Lee JH; Wei ZZ; Chen D; Gu X; Wei L; Yu SP
SRC tyrosine kinases regulate neuronal differentiation of mouse embryonic stem cells via modulation of voltage-gated sodium channel activity.
Neurochem Res Volume: 40 Page(s): 674 - 687
04/01/2015 Authors: Francis KR; Wei L; Yu SP
Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats.
Cell Transplant Volume: 24 Page(s): 391 - 402
01/01/2015 Authors: Wei ZZ; Gu X; Ferdinand A; Lee JH; Ji X; Ji XM; Yu SP; Wei L
Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice.
ASN Neuro Volume: 7
01/01/2015 Authors: Chen D; Lee J; Gu X; Wei L; Yu SP
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
Nat Med Volume: 20 Page(s): 1254 - 1262
11/01/2014 Authors: Zhang Z; Song M; Liu X; Kang SS; Kwon I-S; Duong DM; Seyfried NT; Hu WT; Liu Z; Wang J-Z
Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells.
BMC Cancer Volume: 14 Page(s): 716
09/26/2014 Authors: Chen D; Song M; Mohamad O; Yu SP
Preconditioning of bone marrow mesenchymal stem cells by prolyl hydroxylase inhibition enhances cell survival and angiogenesis in vitro and after transplantation into the ischemic heart of rats.
Stem Cell Res Ther Volume: 5 Page(s): 111
09/25/2014 Authors: Liu X-B; Wang J-A; Ji X-Y; Yu SP; Wei L
Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in mice.
J Neurotrauma Volume: 31 Page(s): 1417 - 1430
08/15/2014 Authors: Lee JH; Wei L; Gu X; Wei Z; Dix TA; Yu SP
Regulatory role of the JNK-STAT1/3 signaling in neuronal differentiation of cultured mouse embryonic stem cells.
Cell Mol Neurobiol Volume: 34 Page(s): 881 - 893
08/01/2014 Authors: Wei ZZ; Yu SP; Lee JH; Chen D; Taylor TM; Deveau TC; Yu ACH; Wei L
The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+).
Br J Pharmacol Volume: 171 Page(s): 3432 - 3447
07/01/2014 Authors: Song M; Chen D; Yu SP
Cell based therapies for ischemic stroke: from basic science to bedside.
Prog Neurobiol Volume: 115 Page(s): 92 - 115
04/01/2014 Authors: Liu X; Ye R; Yan T; Yu SP; Wei L; Xu G; Fan X; Jiang Y; Stetler RA; Liu G
7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.
Neuropsychopharmacology Volume: 39 Page(s): 638 - 650
02/01/2014 Authors: Zhang Z; Liu X; Schroeder JP; Chan C-B; Song M; Yu SP; Weinshenker D; Ye K
Ionic regulation of cell volume changes and cell death after ischemic stroke.
Transl Stroke Res Volume: 5 Page(s): 17 - 27
02/01/2014 Authors: Song M; Yu SP
Ion channels in regulation of neuronal regenerative activities.
Transl Stroke Res Volume: 5 Page(s): 156 - 162
02/01/2014 Authors: Chen D; Yu SP; Wei L
Mobilization of endogenous bone marrow derived endothelial progenitor cells and therapeutic potential of parathyroid hormone after ischemic stroke in mice.
PLoS One Volume: 9 Page(s): e87284
01/01/2014 Authors: Wang L-L; Chen D; Lee J; Gu X; Alaaeddine G; Li J; Wei L; Yu SP
Acute and delayed protective effects of pharmacologically induced hypothermia in an intracerebral hemorrhage stroke model of mice.
Neuroscience Volume: 252 Page(s): 489 - 500
11/12/2013 Authors: Wei S; Sun J; Li J; Wang L; Hall CL; Dix TA; Mohamad O; Wei L; Yu SP
Purification of cardiomyocytes from differentiating pluripotent stem cells using molecular beacons that target cardiomyocyte-specific mRNA.
Circulation Volume: 128 Page(s): 1897 - 1909
10/22/2013 Authors: Ban K; Wile B; Kim S; Park H-J; Byun J; Cho K-W; Saafir T; Song M-K; Yu SP; Wagner M
The involvement of autophagy pathway in exaggerated ischemic brain damage in diabetic mice.
CNS Neurosci Ther Volume: 19 Page(s): 753 - 763
10/01/2013 Authors: Wei N; Yu S-P; Gu X-H; Chen D-D; Whalin MK; Xu G-L; Liu X-F; Wei L
Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.
J Cell Biol Volume: 202 Page(s): 1123 - 1138
09/30/2013 Authors: Xu Q; Huang S; Song M; Wang C-E; Yan S; Liu X; Gaertig MA; Yu SP; Li H; Li S
Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells.
Int J Cardiol Volume: 168 Page(s): 41 - 52
09/20/2013 Authors: Moon S-H; Ban K; Kim C; Kim S-S; Byun J; Song M-K; Park I-H; Yu SP; Yoon Y-S
The regulatory role of NF-B in autophagy-like cell death after focal cerebral ischemia in mice.
Neuroscience Volume: 244 Page(s): 16 - 30
08/06/2013 Authors: Li W-L; Yu SP; Chen D; Yu SS; Jiang Y-J; Genetta T; Wei L
A differential role of macrophage TRPM2 channels in Ca signaling and cell death in early responses to HO.
Am J Physiol Cell Physiol Volume: 305 Page(s): C61 - C69
07/01/2013 Authors: Zou J; Ainscough JF; Yang W; Sedo A; Yu S-P; Mei Z-Z; Sivaprasadarao A; Beech DJ; Jiang L-H
Coordinated development of voltage-gated Na+ and K+ currents regulates functional maturation of forebrain neurons derived from human induced pluripotent stem cells.
Stem Cells Dev Volume: 22 Page(s): 1551 - 1563
05/15/2013 Authors: Song M; Mohamad O; Chen D; Yu SP
Sugar starvation- and GA-inducible calcium-dependent protein kinase 1 feedback regulates GA biosynthesis and activates a 14-3-3 protein to confer drought tolerance in rice seedlings.
Plant Mol Biol Volume: 81 Page(s): 347 - 361
03/01/2013 Authors: Ho S-L; Huang L-F; Lu C-A; He S-L; Wang C-C; Yu S-P; Chen J; Yu S-M
Preconditioning strategy in stem cell transplantation therapy.
Transl Stroke Res Volume: 4 Page(s): 76 - 88
02/01/2013 Authors: Yu SP; Wei Z; Wei L
Efficient neuronal differentiation of mouse ES and iPS cells using a rotary cell culture protocol.
Differentiation Volume: 86 Page(s): 149 - 158
01/01/2013 Authors: Mohamad O; Yu SP; Chen D; Ogle M; Song M; Wei L
Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells.
Int J Physiol Pathophysiol Pharmacol Volume: 5 Page(s): 11 - 20
01/01/2013 Authors: Gu H; Yu SP; Gutekunst C-A; Gross RE; Wei L
Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice.
Cell Transplant Volume: 22 Page(s): 2001 - 2015
01/01/2013 Authors: Song M; Mohamad O; Gu X; Wei L; Yu SP
Neuro-modulating effects of honokiol: a review.
Front Neurol Volume: 4 Page(s): 130
01/01/2013 Authors: Woodbury A; Yu SP; Wei L; Garca P
Stem cells and ion channels.
Stem Cells Int Volume: 2013 Page(s): 238635
01/01/2013 Authors: Liebau S; Kleger A; Levin M; Yu SP
Vector-free and transgene-free human iPS cells differentiate into functional neurons and enhance functional recovery after ischemic stroke in mice.
PLoS One Volume: 8 Page(s): e64160
01/01/2013 Authors: Mohamad O; Drury-Stewart D; Song M; Faulkner B; Chen D; Yu SP; Wei L
Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice.
Cell Transplant Volume: 22 Page(s): 977 - 991
01/01/2013 Authors: Wei N; Yu SP; Gu X; Taylor TM; Song D; Liu X-F; Wei L
Regulatory roles of the NMDA receptor GluN3A subunit in locomotion, pain perception and cognitive functions in adult mice.
J Physiol Volume: 591 Page(s): 149 - 168
01/01/2013 Authors: Mohamad O; Song M; Wei L; Yu SP
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
J Neurosci Volume: 32 Page(s): 17262 - 17272
11/28/2012 Authors: Hong Y; Chan CB; Kwon I-S; Li X; Song M; Lee H-P; Liu X; Sompol P; Jin P; Lee H-G
Cell death and cerebral metabolism after ischemic stroke
JOURNAL OF NEUROCHEMISTRY Volume: 123 Page(s): 26 - 26
10/01/2012 Authors: Yu SP; Wei L
Calcium mediates high glucose-induced HIF-1 and VEGF expression in cultured rat retinal Mller cells through CaMKII-CREB pathway.
Acta Pharmacol Sin Volume: 33 Page(s): 1030 - 1036
08/01/2012 Authors: Li J; Zhao S-Z; Wang P-P; Yu S-P; Zheng Z; Xu X
A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice.
FASEB J Volume: 26 Page(s): 2799 - 2810
07/01/2012 Authors: Choi K-E; Hall CL; Sun J-M; Wei L; Mohamad O; Dix TA; Yu SP
Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats.
Neurobiol Dis Volume: 46 Page(s): 635 - 645
06/01/2012 Authors: Wei L; Fraser JL; Lu Z-Y; Hu X; Yu SP
Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosis.
Stem Cell Res Volume: 8 Page(s): 357 - 367
05/01/2012 Authors: Zeng X; Yu SP; Taylor T; Ogle M; Wei L
N-methyl-D-aspartate receptor subtype 3A promotes apoptosis in developing mouse brain exposed to hyperoxia.
Neural Regen Res Volume: 7 Page(s): 273 - 277
02/05/2012 Authors: Li J; Yu S; Lu Z; Mohamad O; Wei L
Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.
Brain Res Volume: 1433 Page(s): 137 - 144
01/18/2012 Authors: Li J; Li J-P; Zhang X; Lu Z; Yu SP; Wei L
The role of VEGF/VEGFR2 signaling in peripheral stimulation-induced cerebral neurovascular regeneration after ischemic stroke in mice.
Exp Brain Res Volume: 214 Page(s): 503 - 513
10/01/2011 Authors: Li W-L; Fraser JL; Yu SP; Zhu J; Jiang Y-J; Wei L
Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation.
Am J Physiol Cell Physiol Volume: 301 Page(s): C362 - C372
08/01/2011 Authors: Hu X; Wei L; Taylor TM; Wei J; Zhou X; Wang J-A; Yu SP
Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats.
Mol Pain Volume: 7 Page(s): 51
07/21/2011 Authors: Mohamad O; Chen D; Zhang L; Hofmann C; Wei L; Yu SP
N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct.
Am J Physiol Renal Physiol Volume: 301 Page(s): F44 - F54
07/01/2011 Authors: Sproul A; Steele SL; Thai TL; Yu S; Klein JD; Sands JM; Bell PD
Potential role of KCNQ/M-channels in regulating neuronal differentiation in mouse hippocampal and embryonic stem cell-derived neuronal cultures.
Exp Neurol Volume: 229 Page(s): 471 - 483
06/01/2011 Authors: Zhou X; Song M; Chen D; Wei L; Yu SP
Novel role of KCNQ2/3 channels in regulating neuronal cell viability.
Cell Death Differ Volume: 18 Page(s): 493 - 505
03/01/2011 Authors: Zhou X; Wei J; Song M; Francis K; Yu SP
Small molecule promoted feeder free and adherent differentiation of functional neurons from human embryonic and induced pluripotent stem cells.
J Stem Cells Volume: 6 Page(s): 1 - 7
01/01/2011 Authors: Drury-Stewart D; Song M; Mohamad O; Yu SP; Wei L
Protective Effect of TNF-alpha p55 gene after Hemorrhage Stroke in Mice
Page(s): 101 - 105
01/01/2011 Authors: Deveau TC; Sun J; Chen D; Barnes A; Li J; Yu SP; Wei L
DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway.
Brain Res Volume: 1359 Page(s): 216 - 226
11/04/2010 Authors: Li J; Li Y; Ogle M; Zhou X; Song M; Yu SP; Wei L
Sublethal transient global ischemia stimulates migration of neuroblasts and neurogenesis in mice.
Transl Stroke Res Volume: 1 Page(s): 184 - 196
09/01/2010 Authors: Li Y; Yu SP; Mohamad O; Genetta T; Wei L
Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons.
Exp Cell Res Volume: 316 Page(s): 1773 - 1783
07/01/2010 Authors: Zeng XJ; Yu SP; Zhang L; Wei L
Neuroprotective efficacy of estrogen in experimental spinal cord injury in rats.
Ann N Y Acad Sci Volume: 1199 Page(s): 90 - 94
06/01/2010 Authors: Samantaray S; Sribnick EA; Das A; Thakore NP; Matzelle D; Yu SP; Ray SK; Wei L; Banik NL
NOVEL ROLE OF M-CHANNELS IN REGULATING NEURONAL CELL VIABILITY
Volume: 110 Page(s): 43 - 43
09/01/2009 Authors: Zhou X; Wei JF; Wei L; Yu SP
Primed for lethal battle: a step forward to enhance the efficacy and efficiency of stem cell transplantation therapy.
J Thorac Cardiovasc Surg Volume: 138 Page(s): 527
09/01/2009 Authors: Ogle ME; Yu SP; Wei L
Neuroprotective efficacy of estrogen in acute and chronic spinal cord injury in rats
Volume: 109 Page(s): 307 - 308
05/01/2009 Authors: Banik NL; Wei L; Samantaray S; Das A; Sribnick EA; Matzelle DD; Ray SK; Yu SP
HUMAN RECOMBINANT ERYTHROPOIETIN REDUCES CELL DEATH AFTER INFLAMMATORY PAIN IN NEONATAL RAT BRAIN
Volume: 108 Page(s): 93 - 94
03/01/2009 Authors: Mahamad O; Zhang L; Yu SP; Wei L
NEUROPROTECTIVE EFFICACY OF ESTROGEN IN ACUTE AND CHRONIC SPINAL CORD INJURY IN RATS
Volume: 108 Page(s): 105 - 105
03/01/2009 Authors: Samantaray S; Das A; Sribnick EA; Matzelle DD; Yu SP; Ray SK; Wei L; Banik NL
Dual roles of tumor necrosis factor-alpha receptor-1 in a mouse model of hindlimb ischemia.
Vasc Med Volume: 14 Page(s): 37 - 46
02/01/2009 Authors: Jiang J; Wang J; Li C; Yu SP; Wei L
Enhanced neurogenesis and cell migration following focal ischemia and peripheral stimulation in mice.
Dev Neurobiol Volume: 68 Page(s): 1474 - 1486
11/01/2008 Authors: Li W-L; Yu SP; Ogle ME; Ding XS; Wei L
Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility.
J Cell Physiol Volume: 217 Page(s): 544 - 557
11/01/2008 Authors: Wei J-F; Wei L; Zhou X; Lu Z-Y; Francis K; Hu X-Y; Liu Y; Xiong W-C; Zhang X; Banik NL
Cell death and proliferation in NF-kappaB p50 knockout mouse after cerebral ischemia.
Brain Res Volume: 1230 Page(s): 281 - 289
09/16/2008 Authors: Li J; Lu Z; Li W-L; Yu SP; Wei L
Therapeutic strategy of erythropoietin in neurological disorders.
CNS Neurol Disord Drug Targets Volume: 7 Page(s): 227 - 234
06/01/2008 Authors: Liu X-B; Wang J-A; Yu SP; Keogh CL; Wei L
Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats.
Stem Cells Volume: 26 Page(s): 1356 - 1365
05/01/2008 Authors: Cui L; Jiang J; Wei L; Zhou X; Fraser JL; Snider BJ; Yu SP
In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain.
Exp Neurol Volume: 210 Page(s): 656 - 670
04/01/2008 Authors: Theus MH; Wei L; Cui L; Francis K; Hu X; Keogh C; Yu SP
Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis.
J Thorac Cardiovasc Surg Volume: 135 Page(s): 799 - 808
04/01/2008 Authors: Hu X; Yu SP; Fraser JL; Lu Z; Ogle ME; Wang J-A; Wei L
Roles of SRC and ERK1/2 kinases in neuronal differentiation of cultured mouse and human embryonic stem cells
Volume: 104 Page(s): 98 - 98
03/01/2008 Authors: Yu SP; Francis K; Theus MH; Li Z; Wei L
Dl-3-n-butylphthalide protects against ischemic neuronal and mitochondrial damage in rodents
Volume: 104 Page(s): 134 - 134
03/01/2008 Authors: WEi L; Lu Z; Li Y; Ogle M; Yu SP
Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood-brain barrier integrity in mice.
Acta Neurochir Suppl Volume: 105 Page(s): 105 - 112
01/01/2008 Authors: Li Y; Ogle ME; Wallace GC; Lu ZY; Yu SP; Wei L
The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats.
J Pharmacol Exp Ther Volume: 322 Page(s): 521 - 528
08/01/2007 Authors: Keogh CL; Yu SP; Wei L
Roles of potassium homeostasis and Na, K-ATPase in apoptosis
Volume: 102 Page(s): 153 - 153
08/01/2007 Authors: Yu SP; Wei L
Multimodality treatment regimen maximizes neuroprotection and locomotor function in spinal cord injury in rats
Volume: 24 Page(s): 1255 - 1255
07/01/2007 Authors: Samantaray S; Guyton MK; Das A; Sribnick E; Matzelle D; Yu S-P; Wei L; Swapan R; Banik N
Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice.
J Cereb Blood Flow Metab Volume: 27 Page(s): 1043 - 1054
05/01/2007 Authors: Li Y; Lu Z; Keogh CL; Yu SP; Wei L
Voltage-dependent and Src-mediated regulation of NMDA receptor single channel outward currents in cortical neurons.
Cell Biochem Biophys Volume: 47 Page(s): 257 - 270
01/01/2007 Authors: Takata T; Hood AY; Yu SP
Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice.
J Cereb Blood Flow Metab Volume: 27 Page(s): 57 - 68
01/01/2007 Authors: Whitaker VR; Cui L; Miller S; Yu SP; Wei L
Critical roles of Src family tyrosine kinases in excitatory neuronal differentiation of cultured embryonic stem cells.
Exp Cell Res Volume: 312 Page(s): 3096 - 3107
10/01/2006 Authors: Theus MH; Wei L; Francis K; Yu SP
Valinomycin-induced apoptosis in Chinese hamster ovary cells.
Neurosci Lett Volume: 405 Page(s): 68 - 73
09/11/2006 Authors: Abdalah R; Wei L; Francis K; Yu SP
Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats.
J Pharmacol Exp Ther Volume: 317 Page(s): 109 - 116
04/01/2006 Authors: Wei L; Han BH; Li Y; Keogh CL; Holtzman DM; Yu SP
Hypoxia- and erythropoietin-preconditioning promotes ES cell survival in vitro and after transplantation into ischemic brain
Volume: 96 Page(s): 122 - 122
03/01/2006 Authors: Yu SP; Theus MH; Cui L; Wei L
Age-related neural degeneration in nuclear-factor kappaB p50 knockout mice.
Neuroscience Volume: 139 Page(s): 965 - 978
01/01/2006 Authors: Lu Z-Y; Yu SP; Wei J-F; Wei L
Tyrosine phosphorylation of Na+, K+-atpase and its role in neuronal apoptosis
Volume: 94 Page(s): 177 - 177
08/01/2005 Authors: Yu SP; Wei L
Angiogenesis and stem cell transplantation as potential treatments of cerebral ischemic stroke.
Pathophysiology Volume: 12 Page(s): 47 - 62
07/01/2005 Authors: Wei L; Keogh CL; Whitaker VR; Theus MH; Yu SP
Novel regulation of Na, K-ATPase by Src tyrosine kinases in cortical neurons.
J Neurochem Volume: 93 Page(s): 1515 - 1523
06/01/2005 Authors: Wang XQ; Yu SP
Preconditioning with sublethal hypoxia induces protection in neural-derived embryonic stem cells in vitro
Volume: 193 Page(s): 247 - 248
05/01/2005 Authors: Hedrick ML; Yu SP; Wei L
Inhibitory effects of clofilium on membrane currents associated with Ca channels, NMDA receptor channels and Na+, K+-ATPase in cortical neurons.
Pharmacology Volume: 73 Page(s): 162 - 168
03/01/2005 Authors: Yang A; Wang XQ; Sun C-S; Wei L; Yu SP
Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia.
Neurobiol Dis Volume: 19 Page(s): 183 - 193
01/01/2005 Authors: Wei L; Cui L; Snider BJ; Rivkin M; Yu SS; Lee C-S; Adams LD; Gottlieb DI; Johnson EM; Yu SP
Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats.
Brain Res Volume: 1022 Page(s): 54 - 61
10/01/2004 Authors: Wei L; Ying D-J; Cui L; Langsdorf J; Yu SP
Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and apoptosis in cortical neurons.
Pflugers Arch Volume: 448 Page(s): 325 - 334
06/01/2004 Authors: Wei L; Xiao AY; Jin C; Yang A; Lu ZY; Yu SP
Neuronal differentiation of embryonic stem cells and the expression and function of SRC-family tyrosine kinases.
Volume: 187 Page(s): 220 - 221
05/01/2004 Authors: Theus MH; Yu SP; Wei L
Potassium attenuates zinc-induced death of cultured cortical astrocytes.
Glia Volume: 46 Page(s): 18 - 27
04/01/2004 Authors: Sheline CT; Takata T; Ying H; Canzoniero LMT; Yang A; Yu SP; Choi DW
Na(+), K(+)-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death.
Biochem Pharmacol Volume: 66 Page(s): 1601 - 1609
10/15/2003 Authors: Yu SP
Ca2+-independent, but voltage- and activity-dependent regulation of the NMDA receptor outward K+ current in mouse cortical neurons.
J Physiol Volume: 551 Page(s): 403 - 417
09/01/2003 Authors: Ichinose T; Yu S; Wang XQ; Yu SP
Regulation and critical role of potassium homeostasis in apoptosis.
Prog Neurobiol Volume: 70 Page(s): 363 - 386
07/01/2003 Authors: Yu SP
Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress.
J Cell Sci Volume: 116 Page(s): 2099 - 2110
05/15/2003 Authors: Wang XQ; Xiao AY; Sheline C; Hyrc K; Yang A; Goldberg MP; Choi DW; Yu SP
Block of Na+,K+-ATPase and induction of hybrid death by 4-aminopyridine in cultured cortical neurons.
J Pharmacol Exp Ther Volume: 305 Page(s): 502 - 506
05/01/2003 Authors: Wang XQ; Xiao AY; Yang A; LaRose L; Wei L; Yu SP
Potassium channel blockers attenuate hypoxia- and ischemia-induced neuronal death in vitro and in vivo.
Stroke Volume: 34 Page(s): 1281 - 1286
05/01/2003 Authors: Wei L; Yu SP; Gottron F; Snider BJ; Zipfel GJ; Choi DW
Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons.
Brain Res Volume: 955 Page(s): 253 - 259
11/15/2002 Authors: Xiao AY; Wang XQ; Yang A; Yu SP
Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons.
J Neurosci Volume: 22 Page(s): 5452 - 5461
07/01/2002 Authors: Heidinger V; Manzerra P; Wang XQ; Strasser U; Yu S-P; Choi DW; Behrens MM
Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons.
J Neurosci Volume: 22 Page(s): 1350 - 1362
02/15/2002 Authors: Xiao AY; Wei L; Xia S; Rothman S; Yu SP
Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation.
J Neurosci Volume: 22 Page(s): 114 - 122
01/01/2002 Authors: Xia S; Lampe PA; Deshmukh M; Yang A; Brown BS; Rothman SM; Johnson EM; Yu SP
Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity.
Proc Natl Acad Sci U S A Volume: 98 Page(s): 11055 - 11061
09/25/2001 Authors: Manzerra P; Behrens MM; Canzoniero LM; Wang XQ; Heidinger V; Ichinose T; Yu SP; Choi DW
Ion homeostasis and apoptosis.
Curr Opin Cell Biol Volume: 13 Page(s): 405 - 411
08/01/2001 Authors: Yu SP; Canzoniero LM; Choi DW
Role of K(+) efflux in apoptosis induced by AMPA and kainate in mouse cortical neurons.
Neuroscience Volume: 108 Page(s): 61 - 67
01/01/2001 Authors: Xiao AY; Homma M; Wang XQ; Wang X; Yu SP
Effects of tetraethylammonium analogs on apoptosis and membrane currents in cultured cortical neurons.
J Pharmacol Exp Ther Volume: 295 Page(s): 524 - 530
11/01/2000 Authors: Wang X; Xiao AY; Ichinose T; Yu SP
Ions, cell volume, and apoptosis.
Proc Natl Acad Sci U S A Volume: 97 Page(s): 9360 - 9362
08/15/2000 Authors: Yu SP; Choi DW
Nitric oxide reduces Ca(2+) and Zn(2+) influx through voltage-gated Ca(2+) channels and reduces Zn(2+) neurotoxicity.
Neuroscience Volume: 100 Page(s): 651 - 661
01/01/2000 Authors: Snider BJ; Choi J; Turetsky DM; Canzoniero LM; Sensi SL; Sheline CT; Wang X; Yu SP; Choi DW
Modulation and genetic identification of the M channel.
Prog Biophys Mol Biol Volume: 73 Page(s): 135 - 166
01/01/2000 Authors: Brown BS; Yu SP
Selective activation of group II mGluRs with LY354740 does not prevent neuronal excitotoxicity.
Neuropharmacology Volume: 38 Page(s): 1621 - 1630
10/01/1999 Authors: Behrens MM; Strasser U; Heidinger V; Lobner D; Yu SP; McDonald JW; Won M; Choi DW
3,5-DHPG-mediated activation of group I mGluRs induces NMDA receptor tyrosine phosphorylation
NEUROPHARMACOLOGY Volume: 38 Page(s): A5 - A6
10/01/1999 Authors: Behrens MM; Heidinger V; Strasser U; Yu SP; Dennis W
Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons.
J Neurochem Volume: 73 Page(s): 933 - 941
09/01/1999 Authors: Yu SP; Yeh CH; Gottron F; Wang X; Grabb MC; Choi DW
Endothelial function and carotid artery wall thickening in patients with early essential hypertension.
J Tongji Med Univ Volume: 19 Page(s): 288 - 303
01/01/1999 Authors: Tu L; Wei W; Liu X; Deng Y; Yu S
Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death.
Neurobiol Dis Volume: 5 Page(s): 81 - 88
08/01/1998 Authors: Yu SP; Farhangrazi ZS; Ying HS; Yeh CH; Choi DW
Endogenous voltage-gated potassium channels in human embryonic kidney (HEK293) cells.
J Neurosci Res Volume: 52 Page(s): 612 - 617
06/01/1998 Authors: Yu SP; Kerchner GA
Indefinite survival of peripheral nerve allografts after temporary Cyclosporine A immunosuppression.
Restor Neurol Neurosci Volume: 13 Page(s): 129 - 139
01/01/1998 Authors: Atchabahian A; Doolabh VB; Mackinnon SE; Yu S; Hunter DA; Flye MW
Measurement of intracellular free zinc in living cortical neurons: routes of entry.
J Neurosci Volume: 17 Page(s): 9554 - 9564
12/15/1997 Authors: Sensi SL; Canzoniero LM; Yu SP; Ying HS; Koh JY; Kerchner GA; Choi DW
Mediation of neuronal apoptosis by enhancement of outward potassium current.
Science Volume: 278 Page(s): 114 - 117
10/03/1997 Authors: Yu SP; Yeh CH; Sensi SL; Gwag BJ; Canzoniero LM; Farhangrazi ZS; Ying HS; Tian M; Dugan LL; Choi DW
Na(+)-Ca2+ exchange currents in cortical neurons: concomitant forward and reverse operation and effect of glutamate.
Eur J Neurosci Volume: 9 Page(s): 1273 - 1281
06/01/1997 Authors: Yu SP; Choi DW
Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons.
J Physiol Volume: 499 ( Pt 3) Page(s): 721 - 732
03/15/1997 Authors: Yu SP; Sensi SL; Canzoniero LM; Buisson A; Choi DW
Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons.
Neurobiol Dis Volume: 3 Page(s): 129 - 135
04/01/1996 Authors: Dugan LL; Gabrielsen JK; Yu SP; Lin TS; Choi DW
DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons.
Eur J Neurosci Volume: 8 Page(s): 138 - 143
01/01/1996 Authors: Buisson A; Yu SP; Choi DW
Roles of arachidonic acid, lipoxygenases and phosphatases in calcium-dependent modulation of M-current in bullfrog sympathetic neurons.
J Physiol Volume: 487 ( Pt 3) Page(s): 797 - 811
09/15/1995 Authors: Yu SP
Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists.
J Pharmacol Exp Ther Volume: 273 Page(s): 554 - 560
04/01/1995 Authors: Lynch JJ; Yu SP; Canzoniero LM; Sensi SL; Choi DW
Concomitant acceleration of the activation and inactivation kinetics of the human delayed rectifier K+ channel (Kv1.1) by Ca(2+)-independent phospholipase A2.
J Biol Chem Volume: 270 Page(s): 2885 - 2888
02/17/1995 Authors: Gubitosi-Klug RA; Yu SP; Choi DW; Gross RW
Regulation of M current by intracellular calcium in bullfrog sympathetic ganglion neurons.
J Neurosci Volume: 14 Page(s): 3487 - 3499
06/01/1994 Authors: Yu SP; O'Malley DM; Adams PR
Delayed application of aurintricarboxylic acid reduces glutamate-induced cortical neuronal injury.
J Neurosci Res Volume: 38 Page(s): 101 - 108
05/01/1994 Authors: Csernansky CA; Canzoniero LM; Sensi SL; Yu SP; Choi DW
Increasing quantal size at the mouse neuromuscular junction and the role of choline.
J Physiol Volume: 433 Page(s): 677 - 704
02/01/1991 Authors: Yu SP; Van der Kloot W
Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine.
Neurosci Lett Volume: 117 Page(s): 111 - 116
09/04/1990 Authors: Yu SP; Van der Kloot W
The nature and origin of calcium-insensitive miniature end-plate potentials at rodent neuromuscular junctions.
J Physiol Volume: 381 Page(s): 607 - 618
12/01/1986 Authors: Lupa MT; Tabti N; Thesleff S; Vyskocil F; Yu SP
Pharmacological characterization of the calcium-insensitive, intermittent acetylcholine release at the rat neuromuscular junction.
Acta Physiol Scand Volume: 128 Page(s): 429 - 436
11/01/1986 Authors: Tabti N; Lupa MT; Yu SP; Thesleff S
A comparison of miniature end-plate potentials at normal, denervated, and long-term botulinum toxin type A poisoned frog neuromuscular junctions.
Pflugers Arch Volume: 407 Page(s): 476 - 481
11/01/1986 Authors: Lupa MT; Yu SP
[Antagonism of non-depolarization muscle relaxants and aminoglycoside antibiotics to the block of neuromuscular junction of the rat diaphragm caused by soman].
Zhongguo Yao Li Xue Bao Volume: 6 Page(s): 11 - 16
03/01/1985 Authors: Yu SP; Liu CG

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