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Profile

Stella Papa MD

  • Department of Neurology
    Professor
  • (404) 727-3131
  • spapa@emory.edu

Education

Degrees

  • Certified Neurologist from Argentine Public Health Ministry,
  • No Degree from National University of Buenos Aires. School of Philosophy
  • MD from National University of Buenos Aires

Research

Focus

  • My research is focused on Experimental Therapeutics for Parkinsons disease and other Movement Disorders. I am interested in understanding the pathophysiologic basis of these disorders to develop new and improved therapies. My studies of functional and structural alterations in basal ganglia networks use electrophysiological and pharmacological approaches.

Publications

  • Research Priorities on the Role of -Synuclein in Parkinson's Disease Pathogenesis.
    Mov Disord Volume: 39 Page(s): 1663 - 1678
    10/01/2024 Authors: Burr J; Edwards RH; Halliday G; Lang AE; Lashuel HA; Melki R; Murayama S; Outeiro TF; Papa SM; Stefanis L
  • Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia.
    Cells Volume: 12
    11/30/2023 Authors: Kochoian BA; Bure C; Papa SM
  • Phosphodiesterase 9 inhibition prolongs the antiparkinsonian action of l-DOPA in parkinsonian non-human primates.
    Neuropharmacology Volume: 212 Page(s): 109060
    07/01/2022 Authors: Masilamoni GJ; Sinon CG; Kochoian BA; Singh A; McRiner AJ; Leventhal L; Papa SM
  • Reply to: "Letter on Discussionof Gait Research".
    Mov Disord Volume: 37 Page(s): 1328
    06/01/2022 Authors: Bohnen NI; Costa RM; Dauer WT; Factor SA; Giladi N; Hallett M; Lewis SJG; Nieuwboer A; Nutt JG; Takakusaki K
  • Cortical Serotonergic and Catecholaminergic Denervation in MPTP-Treated Parkinsonian Monkeys.
    Cereb Cortex Volume: 32 Page(s): 1804 - 1822
    04/20/2022 Authors: Masilamoni GJ; Weinkle A; Papa SM; Smith Y
  • Addressing the Challenges of Clinical Research for Freezing of Gait in Parkinson's Disease.
    Mov Disord Volume: 37 Page(s): 264 - 267
    02/01/2022 Authors: Lewis SJG; Factor SA; Giladi N; Hallett M; Nieuwboer A; Nutt JG; Przedborski S; Papa SM; MDS Scientific Issues Committee
  • Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.
    Mov Disord Volume: 37 Page(s): 253 - 263
    02/01/2022 Authors: Bohnen NI; Costa RM; Dauer WT; Factor SA; Giladi N; Hallett M; Lewis SJG; Nieuwboer A; Nutt JG; Takakusaki K
  • Striatal FosB gene suppression inhibits the development of abnormal involuntary movements induced by L-Dopa in rats.
    Gene Ther Volume: 28 Page(s): 760 - 770
    12/01/2021 Authors: Beck G; Zhang J; Fong K; Mochizuki H; Mouradian MM; Papa SM
  • Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease.
    Mov Disord Volume: 36 Page(s): 1772 - 1780
    08/01/2021 Authors: Barbuti PA; Barker RA; Brundin P; Przedborski S; Papa SM; Kalia LV; Mochizuki H; MDS Scientific Issues Committee
  • COVID-19 Vaccination for Persons with Parkinson's Disease: Light at the End of the Tunnel?
    J Parkinsons Dis Volume: 11 Page(s): 3 - 8
    01/01/2021 Authors: Bloem BR; Trenkwalder C; Sanchez-Ferro A; Kalia LV; Alcalay R; Chiang H-L; Kang UJ; Goetz C; Brundin P; Papa SM
  • Striatal Oscillations in Parkinsonian Non-Human Primates.
    Neuroscience Volume: 449 Page(s): 116 - 122
    11/21/2020 Authors: Singh A; Papa SM
  • Transcriptomic approach predicts a major role for transforming growth factor beta type 1 pathway in L-Dopa-induced dyskinesia in parkinsonian rats.
    Genes Brain Behav Volume: 19 Page(s): e12690
    11/01/2020 Authors: Dyavar SR; Potts LF; Beck G; Dyavar Shetty BL; Lawson B; Podany AT; Fletcher CV; Amara RR; Papa SM
  • Impact of the COVID-19 Pandemic on Parkinson's Disease and Movement Disorders
    MOVEMENT DISORDERS Volume: 35 Page(s): 711 - 715
    05/01/2020 Authors: Papa SM; Brundin P; Fung VSC; Kang UJ; Burn DJ; Colosimo C; Chiang H-L; Alcalay RN; Trenkwalder C
  • Impact of the COVID-19 Pandemic on Parkinson's Disease and Movement Disorders.
    Mov Disord Clin Pract Volume: 7 Page(s): 357 - 360
    05/01/2020 Authors: Papa SM; Brundin P; Fung VSC; Kang UJ; Burn DJ; Colosimo C; Chiang H-L; Alcalay RN; Trenkwalder C; MDSScientific Issues Committee
  • Impact of the COVID-19 Pandemic on Parkinson's Disease and Movement Disorders.
    Mov Disord Volume: 35 Page(s): 711 - 715
    05/01/2020 Authors: Papa SM; Brundin P; Fung VSC; Kang UJ; Burn DJ; Colosimo C; Chiang H-L; Alcalay RN; Trenkwalder C; MDS-Scientific Issues Committee
  • Structurally distinct -synuclein fibrils induce robust parkinsonian pathology.
    Mov Disord Volume: 35 Page(s): 256 - 267
    02/01/2020 Authors: Hayakawa H; Nakatani R; Ikenaka K; Aguirre C; Choong C-J; Tsuda H; Nagano S; Koike M; Ikeuchi T; Hasegawa M
  • Role of striatal FosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates.
    Proc Natl Acad Sci U S A Volume: 116 Page(s): 18664 - 18672
    09/10/2019 Authors: Beck G; Singh A; Zhang J; Potts LF; Woo J-M; Park ES; Mochizuki H; Mouradian MM; Papa SM
  • MarmoDetector: A novel 3D automated system for the quantitative assessment of marmoset behavior.
    J Neurosci Methods Volume: 322 Page(s): 23 - 33
    07/01/2019 Authors: Yabumoto T; Yoshida F; Miyauchi H; Baba K; Tsuda H; Ikenaka K; Hayakawa H; Koyabu N; Hamanaka H; Papa SM
  • Striatal spreading depolarization: Possible implication in levodopa-induced dyskinetic-like behavior.
    Mov Disord Volume: 34 Page(s): 832 - 844
    06/01/2019 Authors: de Iure A; Napolitano F; Beck G; Quiroga Varela A; Durante V; Sciaccaluga M; Mazzocchetti P; Megaro A; Tantucci M; Cardinale A
  • A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys.
    Mov Disord Volume: 33 Page(s): 805 - 814
    05/01/2018 Authors: Beck G; Maehara S; Chang PL; Papa SM
  • Dysregulation of striatal projection neurons in Parkinson's disease.
    J Neural Transm (Vienna) Volume: 125 Page(s): 449 - 460
    03/01/2018 Authors: Beck G; Singh A; Papa SM
  • Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates.
    Cell Rep Volume: 22 Page(s): 941 - 952
    01/23/2018 Authors: Singh A; Jenkins MA; Burke KJ; Beck G; Jenkins A; Scimemi A; Traynelis SF; Papa SM
  • TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.
    Front Cell Neurosci Volume: 12 Page(s): 417
    01/01/2018 Authors: Zheng C; Chen G; Tan Y; Zeng W; Peng Q; Wang J; Cheng C; Yang X; Nie S; Xu Y
  • TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.
    Front Cell Neurosci Volume: 12 Page(s): 485
    01/01/2018 Authors: Zheng C; Chen G; Tan Y; Zeng W; Peng Q; Wang J; Cheng C; Yang X; Nie S; Xu Y
  • Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms.
    Neuroscience Volume: 340 Page(s): 23 - 33
    01/06/2017 Authors: Han C; Nie S; Chen G; Ma K; Xiong N; Zhang Z; Xu Y; Wang T; Papa SM; Cao X
  • Antidyskinetic Effects of MEK Inhibitor Are Associated with Multiple Neurochemical Alterations in the Striatum of Hemiparkinsonian Rats.
    Front Neurosci Volume: 11 Page(s): 112
    01/01/2017 Authors: Chen G; Nie S; Han C; Ma K; Xu Y; Zhang Z; Papa SM; Cao X
  • Physiology of freezing of gait.
    Ann Neurol Volume: 80 Page(s): 644 - 659
    11/01/2016 Authors: Snijders AH; Takakusaki K; Debu B; Lozano AM; Krishna V; Fasano A; Aziz TZ; Papa SM; Factor SA; Hallett M
  • Effects of a novel phosphodiesterase 10A inhibitor in non-human primates: A therapeutic approach for schizophrenia with improved side effect profile.
    Neuropharmacology Volume: 110 Page(s): 449 - 457
    11/01/2016 Authors: Masilamoni GJ; Uthayathas S; Koenig G; Leventhal L; Papa SM
  • Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson's disease.
    Proc Natl Acad Sci U S A Volume: 113 Page(s): 9629 - 9634
    08/23/2016 Authors: Singh A; Mewes K; Gross RE; DeLong MR; Obeso JA; Papa SM
  • Nalbuphine Efficacy for L-Dopa-induced Dyskinesia in Parkinson Disease
    Volume: 13 Page(s): 650 - 650
    07/01/2016 Authors: Mouradian MM; Papa SM; Voronkov M; Braithwaite SP
  • MEK inhibitors have antidyskinetic effects in hemiParkinsonian rats that are associated with critical neurochemical alterations in the striatum
    Volume: 31 Page(s): S293 - S293
    06/01/2016 Authors: Chen G; Nie S; Ma K; Han C; Xu Y; Zhang Z; Papa SM; Cao X
  • Intrastriatal injection of ionomycin profoundly changes motor response to L-DOPA and its underlying molecular mechanisms
    Volume: 31 Page(s): S286 - S286
    06/01/2016 Authors: Han C; Nie S; Chen G; Ma K; Xiong N; Zhang Z; Xu Y; Wang T; Papa SM; Cao X
  • Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates.
    Neurosci Bull Volume: 31 Page(s): 705 - 713
    12/01/2015 Authors: Singh A; Gutekunst CA; Uthayathas S; Finberg JPM; Mewes K; Gross RE; Papa SM; Feld Y
  • Interaction between hyperdirect and indirect basal ganglia pathways.
    Mov Disord Volume: 30 Page(s): 909
    06/01/2015 Authors: Papa SM; Wichmann T
  • Dual -agonist/-antagonist opioid receptor modulation reduces levodopa-induced dyskinesia and corrects dysregulated striatal changes in the nonhuman primate model of Parkinson disease.
    Ann Neurol Volume: 77 Page(s): 930 - 941
    06/01/2015 Authors: Potts LF; Park ES; Woo J-M; Dyavar Shetty BL; Singh A; Braithwaite SP; Voronkov M; Papa SM; Mouradian MM
  • Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates.
    J Neurophysiol Volume: 113 Page(s): 1533 - 1544
    03/01/2015 Authors: Singh A; Liang L; Kaneoke Y; Cao X; Papa SM
  • A new quantitative rating scale for dyskinesia in nonhuman primates.
    Behav Pharmacol Volume: 26 Page(s): 109 - 116
    02/01/2015 Authors: Potts LF; Uthayathas S; Greven ACM; Dyavarshetty B; Mouradian MM; Papa SM
  • Levetiracetam Ameliorates L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats Inducing Critical Molecular Changes in the Striatum.
    Parkinsons Dis Volume: 2015 Page(s): 253878
    01/01/2015 Authors: Du H; Nie S; Chen G; Ma K; Xu Y; Zhang Z; Papa SM; Cao X
  • Profound Activity Changes in Striatal Output Neurons in Parkinsonian Patients
    Volume: 76 Page(s): S45 - S45
    10/01/2014 Authors: Singh A; Mewes K; Gross R; DeLong MR; Papa SM
  • Modeling Parkinson's disease in monkeys for translational studies, a critical analysis.
    Exp Neurol Volume: 256 Page(s): 133 - 143
    06/01/2014 Authors: Potts LF; Wu H; Singh A; Marcilla I; Luquin MR; Papa SM
  • NMDA and AMPA receptor antagonists reduce abnormal striatal neuronal activity and facilitate dopamine modulation
    Volume: 29 Page(s): S287 - S287
    05/01/2014 Authors: Singh A; Burke KJ; Whithear JS; Dyavarshetty B; Papa SM
  • Fibroblast transplantion in the internal pallidum reduces L-Dopa-induced dyskinesias in MPTP treated non-human primates
    Volume: 29 Page(s): S41 - S41
    05/01/2014 Authors: Feld Y; Singh A; Gutekunst C-A; Uthayathas S; Gross RE; Papa SM
  • Pathological striatal activity in patients with advanced Parkinson's disease
    Volume: 29 Page(s): S287 - S287
    05/01/2014 Authors: Singh A; Mewes K; DeLong MR; Papa SM
  • Phosphodiesterase 10A inhibitor MP-10 effects in primates: comparison with risperidone and mechanistic implications.
    Neuropharmacology Volume: 77 Page(s): 257 - 267
    02/01/2014 Authors: Uthayathas S; Masilamoni GJ; Shaffer CL; Schmidt CJ; Menniti FS; Papa SM
  • Stabilization of Dopamine Responses in Striatal Neurons by Blockade of NMDA Receptor Transmission in Parkinsonian Monkeys
    Volume: 74 Page(s): S41 - S41
    10/01/2013 Authors: Singh A; Burke KJ; Whithear JS; Shetty BLD; Papa SM
  • Altered Striatal Activity as a Therapeutic Target in Parkinson's Disease
    NEUROTHERAPEUTICS Volume: 10 Page(s): 542 - 543
    07/01/2013 Authors: Singh A; Potts LF; Mewes K; Gross R; DeLong MR; Papa SM
  • The synthetic opioid nalbuphine reduces L-dopa-induced dyskinesia in non-human primates
    MOVEMENT DISORDERS Volume: 28 Page(s): S216 - S216
    06/01/2013 Authors: Potts LF; Greven A; Shetty BLD; Whithear JS; Braithwaite SP; Voronkov M; Papa SM; Mouradian MM
  • A new, quantitative scale for evaluating L-dopa-induced dyskinesia in non-human primates
    MOVEMENT DISORDERS Volume: 28 Page(s): S115 - S115
    06/01/2013 Authors: Potts LF; Uthayathas S; Greven A; Shetty BD; Whithear JS; Mouradian MM; Papa SM
  • Assessment of adverse effects of neurotropic drugs in monkeys with the "drug effects on the nervous system" (DENS) scale.
    J Neurosci Methods Volume: 215 Page(s): 97 - 102
    04/30/2013 Authors: Uthayathas S; Shaffer CL; Menniti FS; Schmidt CJ; Papa SM
  • Non-human primate FOG develops with advanced parkinsonism induced by MPTP Treatment.
    Exp Neurol Volume: 237 Page(s): 464 - 469
    10/01/2012 Authors: Revuelta GJ; Uthayathas S; Wahlquist AE; Factor SA; Papa SM
  • The Discharge of Striatal Neurons Is Profoundly Altered in Patients with Parkinson's Disease
    Volume: 72 Page(s): S130 - S131
    01/01/2012 Authors: Singh A; Potts LF; Mewes K; Gross R; DeLong MR; Papa SM
  • Striatal overexpression of DeltaFosB reproduces chronic levodopa-induced involuntary movements.
    J Neurosci Volume: 30 Page(s): 7335 - 7343
    05/26/2010 Authors: Cao X; Yasuda T; Uthayathas S; Watts RL; Mouradian MM; Mochizuki H; Papa SM
  • Quantitative autoradiographic study on receptor regulation in the basal ganglia in rat model of levodopa-induced motor complications.
    J Huazhong Univ Sci Technolog Med Sci Volume: 29 Page(s): 156 - 162
    04/01/2009 Authors: Xu Y; Zhang Z; Qin K; Papa SM; Cao X
  • Responses of Striatal Neurons to Dopamine Are Profoundly Altered in Chronic Parkinsonian Monkeys
    Volume: 66 Page(s): S51 - S51
    01/01/2009 Authors: Liang L; Kaneoke Y; Papa SM
  • Inversion of dopamine responses in striatal medium spiny neurons and involuntary movements.
    J Neurosci Volume: 28 Page(s): 7537 - 7547
    07/23/2008 Authors: Liang L; DeLong MR; Papa SM
  • Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys.
    J Pharmacol Exp Ther Volume: 323 Page(s): 318 - 326
    10/01/2007 Authors: Cao X; Liang L; Hadcock JR; Iredale PA; Griffith DA; Menniti FS; Factor S; Greenamyre JT; Papa SM
  • Chronic FRA proteins are involved in the development of motor complications associated with long-term levodopa therapy.
    Volume: 68 Page(s): A111 - A111
    03/20/2007 Authors: Cao X; Yasuda T; Mochizuki H; Papa SM
  • Patterns of striatal neuronal activity associated to motor states in the parkinsonian monkey
    Volume: 21 Page(s): S352 - S352
    01/01/2006 Authors: Liang L; Kaneoke Y; DeLong MR; Papa SM
  • Selective cannabinoid CB1 antagonist increases levodopa responses in parkinsonian monkeys
    Volume: 60 Page(s): S71 - S71
    01/01/2006 Authors: Cao X; Iredale PA; Menniti FS; Greenamyre JT; Papa SM
  • Prolongation of levodopa responses by glycineB antagonists in parkinsonian primates.
    Ann Neurol Volume: 56 Page(s): 723 - 727
    11/01/2004 Authors: Papa SM; Auberson YP; Greenamyre JT
  • Glycine(B) receptor blockade amplifies levodopa responses in MPTP parkinsonian monkeys
    Volume: 62 Page(s): A257 - A257
    04/13/2004 Authors: Papa SM; Greenamyre T
  • Patterns of GPI activity associated with different motor states in parkinsonian monkeys
    NEUROLOGY Volume: 58 Page(s): A240 - A240
    04/09/2002 Authors: Papa SM; Baron MS; DeLong MR; Kaneoke Y
  • Neuronal activity correlates of levodopa-induced dyskinesias in the basal ganglia
    NEUROLOGY Volume: 54 Page(s): A456 - A456
    04/11/2000 Authors: Papa SM; Mewes K; DeLong MR; Baron MS
  • Internal globus pallidus discharge is nearly suppressed during levodopa-induced dyskinesias.
    Ann Neurol Volume: 46 Page(s): 732 - 738
    11/01/1999 Authors: Papa SM; Desimone R; Fiorani M; Oldfield EH
  • Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease.
    Neurosci Biobehav Rev Volume: 21 Page(s): 447 - 453
    07/01/1997 Authors: Blanchet PJ; Papa SM; Metman LV; Mouradian MM; Chase TN
  • MK-801 prevents levodopa-induced motor response alterations in parkinsonian rats.
    Brain Res Volume: 736 Page(s): 202 - 205
    10/14/1996 Authors: Marin C; Papa S; Engber TM; Bonastre M; Tolosa E; Chase TN
  • Progressive choreic and dystonic dyskinesias induced by a D1 agonist in nonprimed MPTP-treated primates
    ANNALS OF NEUROLOGY Volume: 40 Page(s): T178 - T178
    09/01/1996 Authors: Papa SM; Blanchet PJ; Chase TN
  • Levodopa-induced dyskinesias improved by a glutamate antagonist in Parkinsonian monkeys.
    Ann Neurol Volume: 39 Page(s): 574 - 578
    05/01/1996 Authors: Papa SM; Chase TN
  • Reversal of levodopa-induced motor fluctuations in experimental parkinsonism by NMDA receptor blockade.
    Brain Res Volume: 701 Page(s): 13 - 18
    12/01/1995 Authors: Papa SM; Boldry RC; Engber TM; Kask AM; Chase TN
  • MK-801 reverses effects of chronic levodopa on D1 and D2 dopamine agonist-induced rotational behavior.
    Brain Res Volume: 692 Page(s): 259 - 264
    09/18/1995 Authors: Boldry RC; Papa SM; Kask AM; Chase TN
  • SUPPRESSION OF LEVODOPA-INDUCED DYSKINESIAS BY AN NMDA RECEPTOR ANTAGONIST IN MPTP TREATED MONKEYS
    NEUROLOGY Volume: 45 Page(s): 1417 - 1417
    07/01/1995 Authors: PAPA SM; BLANCHET PJ; LINFANTE I; CHASE TN
  • NMDA receptor blockade reverses motor response alterations induced by levodopa.
    Neuroreport Volume: 5 Page(s): 2586 - 2588
    12/20/1994 Authors: Engber TM; Papa SM; Boldry RC; Chase TN
  • Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration.
    Brain Res Volume: 662 Page(s): 69 - 74
    10/31/1994 Authors: Papa SM; Engber TM; Kask AM; Chase TN
  • STRIATAL NMDA RECEPTOR BLOCKADE REVERSES LEVODOPA-INDUCED WEARING-OFF
    NEUROLOGY Volume: 44 Page(s): A258 - A258
    04/01/1994 Authors: PAPA SM; ENGBER TM; CHASE TN
  • Excitatory amino acid receptor antagonists modify regional cerebral metabolic responses to levodopa in 6-hydroxydopamine-lesioned rats.
    Neuroscience Volume: 59 Page(s): 389 - 399
    03/01/1994 Authors: Engber TM; Anderson JJ; Boldry RC; Papa SM; Kuo S; Chase TN
  • EFFECTS OF CHRONIC LEVODOPA TREATMENT ON DOPAMINE, EXCITATORY AMINO-ACID, AND GAMMA-AMINOBUTYRIC-ACID RECEPTORS IN BASAL GANGLIA
    ANNALS OF NEUROLOGY Volume: 34 Page(s): 300 - 300
    08/01/1993 Authors: PAPA SM; ENGBER TM; CHASE TN
  • MOTOR RESPONSE VARIATIONS PRODUCED BY CHRONIC LEVODOPA TREATMENT IN 6-HYDROXYDOPAMINE-LESIONED RATS
    NEUROLOGY Volume: 43 Page(s): A152 - A152
    04/01/1993 Authors: PAPA SM; ENGBER TM; CHASE TN
  • Opposite effects of NMDA and AMPA receptor blockade on catalepsy induced by dopamine receptor antagonists.
    Eur J Pharmacol Volume: 232 Page(s): 247 - 253
    03/02/1993 Authors: Papa SM; Engber TM; Boldry RC; Chase TN
  • Cortical activity preceding self-initiated and externally triggered voluntary movement.
    Mov Disord Volume: 6 Page(s): 217 - 224
    01/01/1991 Authors: Papa SM; Artieda J; Obeso JA
  • Orthostatic tremor: an essential tremor variant?
    Mov Disord Volume: 3 Page(s): 97 - 108
    01/01/1988 Authors: Papa SM; Gershanik OS
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