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Profile

Shoichiro Ono PhD

  • Department of Pathology and Laboratory Medicine
    Associate Professor
  • (404) 727-3916
  • sono@emory.edu
Head shot of Shoichiro Ono

Academic Appointment

  • Associate Professor, Department of Cell Biology, Emory University
  • Associate Professor, Department of Pathology, Emory University

Education

Degrees

  • PhD from Chiba University
  • BA from Chiba University
  • M.Sc from Chiba University

Research

Focus

  • Regulation of actin filament dynamics in muscle development, embryogenesis, endocytosis and cell motility. Actin filaments are the core of the actin cytoskeleton and play fundamental roles in a number of cell biological processes. Defects in regulation of the actin cytoskeleton often cause human diseases. My research focus is to understand the basic mechanisms by which actin polymerization, depolymerization, cytoskeletal organization are regulated.

Publications

  • Overexpression of Lifeact in the C. elegans body wall muscle causes sarcomere disorganization and embryonic or larval lethality.
    Front Cell Dev Biol Volume: 12 Page(s): 1504980
    01/01/2024 Authors: Ono S
  • Segregated localization of two calponin-related proteins within sarcomeric thin filaments in Caenorhabditis elegans striated muscle.
    Cytoskeleton (Hoboken) Volume: 81 Page(s): 127 - 140
    01/01/2024 Authors: Ono S
  • The -arrestin SUP-13/ARRD-15 promotes isoform turnover of actin-interacting protein 1 in Caenorhabditis elegans striated muscle.
    PNAS Nexus Volume: 2 Page(s): pgad330
    10/01/2023 Authors: Lewis M; Ono K; Qin Z; Johnsen RC; Baillie DL; Ono S
  • Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments.
    Front Cell Dev Biol Volume: 11 Page(s): 1208913
    01/01/2023 Authors: Ono S; Watabe E; Morisaki K; Ono K; Kuroyanagi H
  • Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle.
    Eur J Cell Biol Volume: 101 Page(s): 151215
    04/01/2022 Authors: Ono S; Lewis M; Ono K
  • Imaging of Actin Cytoskeleton in the Nematode Caenorhabditis elegans.
    Methods Mol Biol Volume: 2364 Page(s): 149 - 158
    01/01/2022 Authors: Ono S
  • Diversification of the calponin family proteins by gene amplification and repeat expansion of calponin-like motifs.
    Cytoskeleton (Hoboken) Volume: 78 Page(s): 199 - 205
    05/01/2021 Authors: Ono S
  • Native cyclase-associated protein and actin from Xenopus laevis oocytes form a unique 4:4 complex with a tripartite structure.
    J Biol Chem Volume: 296 Page(s): 100649
    01/01/2021 Authors: Kodera N; Abe H; Nguyen PDN; Ono S
  • Mechanochemical coupling of formin-induced actin interaction at the level of single molecular complex.
    Biomech Model Mechanobiol Volume: 19 Page(s): 1509 - 1521
    10/01/2020 Authors: Li Z; Lee H; Eskin SG; Ono S; Zhu C; McIntire LV
  • Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction.
    J Biol Chem Volume: 295 Page(s): 12014 - 12027
    08/21/2020 Authors: Ono S; Ono K
  • Dynamic Phosphorylation and Dephosphorylation of CAP1 (Cyclase-Associated Protein 1) by Antagonistic Signaling through CDK5 and cAMP are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion
    Volume: 34
    04/01/2020 Authors: Xiao Y; Zhang H; Ramsey A; Karki U; Akana L; Xie J; Xu J; Kelly T; Ono S; Zhou G
  • Cofilin-induced structural changes in actin filaments stay local.
    Proc Natl Acad Sci U S A Volume: 117 Page(s): 3349 - 3351
    02/18/2020 Authors: Ono S
  • Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditiselegans.
    FEBS J Volume: 287 Page(s): 659 - 670
    02/01/2020 Authors: Ono K; Qin Z; Johnsen RC; Baillie DL; Ono S
  • Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion.
    Mol Cell Biol Volume: 40
    01/30/2020 Authors: Zhang H; Ramsey A; Xiao Y; Karki U; Xie JY; Xu J; Kelly T; Ono S; Zhou G-L
  • Publisher Correction: An actin-based viscoplastic lock ensures progressive body-axis elongation.
    Nature Volume: 574 Page(s): E17
    10/01/2019 Authors: Lardennois A; Psti G; Ferraro T; Llense F; Mahou P; Pontabry J; Rodriguez D; Kim S; Ono S; Beaurepaire E
  • Publisher Correction: An actin-based viscoplastic lock ensures progressive body-axis elongation.
    Nature Volume: 573 Page(s): E4
    09/01/2019 Authors: Lardennois A; Psti G; Ferraro T; Llense F; Mahou P; Pontabry J; Rodriguez D; Kim S; Ono S; Beaurepaire E
  • An actin-based viscoplastic lock ensures progressive body-axis elongation.
    Nature Volume: 573 Page(s): 266 - 270
    09/01/2019 Authors: Lardennois A; Psti G; Ferraro T; Llense F; Mahou P; Pontabry J; Rodriguez D; Kim S; Ono S; Beaurepaire E
  • Force-history dependence and cyclic mechanical reinforcement of actin filaments at the single molecular level.
    J Cell Sci Volume: 132
    02/04/2019 Authors: Lee H; Eskin SG; Ono S; Zhu C; McIntire LV
  • Real-Time Single-Molecule Kinetic Analyses of AIP1-Enhanced Actin Filament Severing in the Presence of Cofilin.
    J Mol Biol Volume: 431 Page(s): 308 - 322
    01/18/2019 Authors: Hayakawa K; Sekiguchi C; Sokabe M; Ono S; Tatsumi H
  • Mutations in Caenorhabditis elegans actin, which are equivalent to human cardiomyopathy mutations, cause abnormal actin aggregation in nematode striated muscle.
    F1000Res Volume: 8 Page(s): 279
    01/01/2019 Authors: Hayashi Y; Ono K; Ono S
  • Kettin, a large actin-binding protein with immunoglobulin-like repeats, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans
    Volume: 29 Page(s): 70 - 71
    12/15/2018 Authors: Ono K; Qin Z; Johnsen RC; Baillie DL; Ono S
  • Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation.
    Biochem Biophys Res Commun Volume: 506 Page(s): 315 - 322
    11/25/2018 Authors: Ono S
  • Alternative splicing of the Caenorhabditis elegans lev-11 tropomyosin gene is regulated in a tissue-specific manner.
    Cytoskeleton (Hoboken) Volume: 75 Page(s): 427 - 436
    10/01/2018 Authors: Watabe E; Ono S; Kuroyanagi H
  • Tropomyosin isoforms differentially affect muscle contractility in the head and body regions of the nematode Caenorhabditis elegans.
    Mol Biol Cell Volume: 29 Page(s): 1075 - 1088
    05/01/2018 Authors: Barnes DE; Watabe E; Ono K; Kwak E; Kuroyanagi H; Ono S
  • Conserved hydrophobic residues in the CARP/-sheet domain of cyclase-associated protein are involved in actin monomer regulation.
    Cytoskeleton (Hoboken) Volume: 74 Page(s): 343 - 355
    09/01/2017 Authors: Iwase S; Ono S
  • A plague of actin disassembly.
    J Biol Chem Volume: 292 Page(s): 8101 - 8102
    05/12/2017 Authors: Ono S
  • Mutation of arrd-15, a gene encoding an alpha-arrestin, suppresses actin disorganization phenotypes in unc-78 AIP1 mutants in C. elegans.
    Volume: 28
    01/01/2017 Authors: Ono K; Iwase S; Qin Z; Baillie DL; Ono S
  • The C-terminal dimerization motif of cyclase-associated protein is essential for actin monomer regulation.
    Biochem J Volume: 473 Page(s): 4427 - 4441
    12/01/2016 Authors: Iwase S; Ono S
  • Regulation of actin catch-slip bonds with a RhoA-formin module.
    Sci Rep Volume: 6 Page(s): 35058
    10/12/2016 Authors: Lee C-Y; Lou J; Wen K-K; McKane M; Eskin SG; Rubenstein PA; Chien S; Ono S; Zhu C; McIntire LV
  • A Novel Alternative Exon of the Caenorhabditis Elegans Lev-11 Tropomyosin Gene is used to Express a Head-Muscle-Specific Isoform
    Volume: 30
    04/01/2016 Authors: Barnes DE; Kuroyanagi H; Ono K; Kwak ET; Ono S
  • A Novel Alternative Exon of the Caenorhabditis Elegans Lev-11 Tropomyosin Gene is used to Express a Head-Muscle-Specific Isoform
    Volume: 30
    04/01/2016 Authors: Barnes DE; Kuroyanagi H; Ono K; Kwak ET; Ono S
  • Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad.
    Mol Biol Cell Volume: 27 Page(s): 1131 - 1142
    04/01/2016 Authors: Ono K; Ono S
  • Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.
    J Biol Chem Volume: 291 Page(s): 5146 - 5156
    03/04/2016 Authors: Nomura K; Hayakawa K; Tatsumi H; Ono S
  • Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion.
    Cytoskeleton (Hoboken) Volume: 73 Page(s): 117 - 130
    03/01/2016 Authors: Barnes DE; Hwang H; Ono K; Lu H; Ono S
  • Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.
    Sci Rep Volume: 6 Page(s): 19900
    01/29/2016 Authors: Hwang H; Barnes DE; Matsunaga Y; Benian GM; Ono S; Lu H
  • Mutational analysis of conserved hydrophobic residues in the C-terminal actin-monomer binding region of cyclase-associated protein
    Volume: 27
    01/01/2016 Authors: Iwase S; Ono S
  • Basic Methods to Visualize Actin Filaments In Vitro Using Fluorescence Microscopy for Observation of Filament Severing and Bundling.
    Methods Mol Biol Volume: 1365 Page(s): 187 - 193
    01/01/2016 Authors: Ono S
  • NMR assignments of actin depolymerizing factor (ADF) like UNC-60A and cofilin like UNC-60B proteins of Caenorhabditis elegans.
    Biomol NMR Assign Volume: 9 Page(s): 261 - 265
    10/01/2015 Authors: Shukla VK; Kabra A; Yadav R; Ono S; Kumar D; Arora A
  • UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility.
    Mol Biol Cell Volume: 26 Page(s): 1687 - 1698
    05/01/2015 Authors: Ono K; Obinata T; Yamashiro S; Liu Z; Ono S
  • C. elegans Troponin I Peptides from Helix 4 and the COOH-terminus Bind Troponin C in vitro: Novel Implications for the Structural Basis of Troponin's Regulatory Mechanism
    Volume: 29
    04/01/2015 Authors: Barnes D; Ono S
  • Essential role of the C-terminal dimerization motif of cyclase-associated protein for recycling of ADF/cofilin-bound actin monomers for polymerization
    MOLECULAR BIOLOGY OF THE CELL Volume: 26
    01/01/2015 Authors: Iwase S; Ono S
  • CLIK-1 and UNC-87, two C-elegans calponin-related proteins, have partially redundant functions in nematode reproduction and muscle contractility
    MOLECULAR BIOLOGY OF THE CELL Volume: 26
    01/01/2015 Authors: Ono K; Ono S
  • Solution structures and dynamics of ADF/cofilins UNC-60A and UNC-60B from Caenorhabditis elegans.
    Biochem J Volume: 465 Page(s): 63 - 78
    01/01/2015 Authors: Shukla VK; Kabra A; Maheshwari D; Yadav R; Jain A; Tripathi S; Ono S; Kumar D; Arora A
  • Calponin-like protein isoforms regulate actomyosin contractility in C. elegans
    Volume: 25
    12/01/2014 Authors: Ono K; Obinata T; Yamashiro S; Liu Z; Ono S
  • Identification of kinases that phosphorylate Xenopus Slingshot phosphatase during oocyte maturation.
    Volume: 25
    12/01/2014 Authors: Iwase S; Ono S; Abe H
  • Regulation of structure and function of sarcomeric actin filaments in striated muscle of the nematode Caenorhabditis elegans.
    Anat Rec (Hoboken) Volume: 297 Page(s): 1548 - 1559
    09/01/2014 Authors: Ono S
  • The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestine.
    Dev Dyn Volume: 243 Page(s): 753 - 764
    06/01/2014 Authors: Cox-Paulson E; Cannataro V; Gallagher T; Hoffman C; Mantione G; Mcintosh M; Silva M; Vissichelli N; Walker R; Simske J
  • Two actin-interacting protein 1 isoforms function redundantly in the somatic gonad and are essential for reproduction in Caenorhabditis elegans.
    Cytoskeleton (Hoboken) Volume: 71 Page(s): 36 - 45
    01/01/2014 Authors: Ono K; Ono S
  • The role of cyclase-associated protein in regulating actin filament dynamics - more than a monomer-sequestration factor.
    J Cell Sci Volume: 126 Page(s): 3249 - 3258
    08/01/2013 Authors: Ono S
  • ATP-dependent regulation of actin monomer-filament equilibrium by cyclase-associated protein and ADF/cofilin.
    Biochem J Volume: 453 Page(s): 249 - 259
    07/15/2013 Authors: Nomura K; Ono S
  • Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes
    MOLECULAR BIOLOGY OF THE CELL Volume: 24 Page(s): 1933 - 1946
    06/15/2013 Authors: Iwase S; Sato R; De Bock P-J; Gevaert K; Fujiki S; Tawada T; Kuchitsu M; Yamagishi Y; Ono S; Abe H
  • Regulatory role of the second gelsolin-like domain of Caenorhabditis elegans gelsolin-like protein 1 (GSNL-1) in its calcium-dependent conformation and actin-regulatory activities.
    Cytoskeleton (Hoboken) Volume: 70 Page(s): 228 - 239
    04/01/2013 Authors: Liu Z; Ono S
  • Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds.
    Proc Natl Acad Sci U S A Volume: 110 Page(s): 5022 - 5027
    03/26/2013 Authors: Lee C-Y; Lou J; Wen K-K; McKane M; Eskin SG; Ono S; Chien S; Rubenstein PA; Zhu C; McIntire LV
  • Procaspase-7 regulates cell actin-cytoskeleton turnover and modulates cell adhesion and motility
    MOLECULAR BIOLOGY OF THE CELL Volume: 24
    01/01/2013 Authors: Brentnall MR; Bray B; Ono S; Marcus AI; Boise LH
  • C. elegans AIP1 promotes disassembly of ADF/cofilin-bound actin filaments in a pH-dependent manner
    MOLECULAR BIOLOGY OF THE CELL Volume: 24
    01/01/2013 Authors: Nomura K; Ono S
  • Actin-interacting protein 1 (AIP1) is essential for reproduction in Caenorhabditis elegans
    MOLECULAR BIOLOGY OF THE CELL Volume: 24
    01/01/2013 Authors: Ono K; Ono S
  • Complexity of tropomyosin isoforms in C. elegans generated by alternative splicing of the lev-11 gene
    MOLECULAR BIOLOGY OF THE CELL Volume: 24
    01/01/2013 Authors: Barnes DE; Kwak E; Ono S
  • CAS-1, a C. elegans cyclase-associated protein, is required for sarcomeric actin assembly in striated muscle.
    J Cell Sci Volume: 125 Page(s): 4077 - 4089
    09/01/2012 Authors: Nomura K; Ono K; Ono S
  • Tropomodulin protects -catenin-dependent junctional-actin networks under stress during epithelial morphogenesis.
    Curr Biol Volume: 22 Page(s): 1500 - 1505
    08/21/2012 Authors: Cox-Paulson EA; Walck-Shannon E; Lynch AM; Yamashiro S; Zaidel-Bar R; Eno CC; Ono S; Hardin J
  • Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
    PLoS Genet Volume: 8 Page(s): e1002991
    01/01/2012 Authors: Ohno G; Ono K; Togo M; Watanabe Y; Ono S; Hagiwara M; Kuroyanagi H
  • Biochemical and cell biological analysis of actin in the nematode Caenorhabditis elegans.
    Methods Volume: 56 Page(s): 11 - 17
    01/01/2012 Authors: Ono S; Pruyne D
  • CAS-2, a second cyclase-associated protein isoform in C. elegans, regulates ADF/cofilin-dependent actin filament dynamics in an ATP-dependent manner.
    MOLECULAR BIOLOGY OF THE CELL Volume: 23
    01/01/2012 Authors: Nomura K; Ono K; Ono S
  • Functional analysis of the N-terminal extension of troponin I muscle contraction and organization in C. elegans striated muscle
    MOLECULAR BIOLOGY OF THE CELL Volume: 23
    01/01/2012 Authors: Barnes DE; Ono K; Ono S
  • Calcium-sensitive activity and conformation of Caenorhabditis elegans gelsolin-like protein 1 are altered by mutations in the first gelsolin-like domain.
    J Biol Chem Volume: 286 Page(s): 34051 - 34059
    09/30/2011 Authors: Liu Z; Kanzawa N; Ono S
  • The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegans.
    Mol Biol Cell Volume: 22 Page(s): 2258 - 2269
    07/01/2011 Authors: Ono S; Nomura K; Hitosugi S; Tu DK; Lee JA; Baillie DL; Ono K
  • Detection of a troponin I-like protein in non-striated muscle of the tardigrades (water bears).
    Bioarchitecture Volume: 1 Page(s): 96 - 102
    03/01/2011 Authors: Obinata T; Ono K; Ono S
  • Structure, Conformational Dynamics, and Evolutionary Conservation of Human Fascin-1
    Volume: 100 Page(s): 34 - 34
    02/02/2011 Authors: Sedeh R; Fedorov A; Fedorov E; Ono S; Matsumura F; Almo S; Bathe M
  • Effects of Caldesmon and Cofilin on the Depolymerization of Actin Filaments
    Volume: 22
    01/01/2011 Authors: Huang R; Nomura K; Ono S; Wang C-LA
  • Cyclase-associated Protein 1 (CAS-1) Promotes Actin Filament Turnover in Cooperation with ADF/Cofilin And Is Essential for Muscle Actin Organization in C. elegans
    Volume: 22
    01/01/2011 Authors: Nomura K; Ono K; Ono S
  • Dynamic regulation of sarcomeric actin filaments in striated muscle.
    Cytoskeleton (Hoboken) Volume: 67 Page(s): 677 - 692
    11/01/2010 Authors: Ono S
  • Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein.
    J Mol Biol Volume: 400 Page(s): 589 - 604
    07/16/2010 Authors: Sedeh RS; Fedorov AA; Fedorov EV; Ono S; Matsumura F; Almo SC; Bathe M
  • Distinct roles of four gelsolin-like domains of Caenorhabditis elegans gelsolin-like protein-1 in actin filament severing, barbed end capping, and phosphoinositide binding.
    Biochemistry Volume: 49 Page(s): 4349 - 4360
    05/25/2010 Authors: Liu Z; Klaavuniemi T; Ono S
  • Rickettsia pays the piper; new actors and some bad actin'.
    Cell Host Microbe Volume: 7 Page(s): 335 - 336
    05/20/2010 Authors: Kalman D; Ono S
  • Troponin I controls ovulatory contraction of non-striated actomyosin networks in the C. elegans somatic gonad.
    J Cell Sci Volume: 123 Page(s): 1557 - 1566
    05/01/2010 Authors: Obinata T; Ono K; Ono S
  • Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells.
    Int Immunol Volume: 22 Page(s): 113 - 128
    02/01/2010 Authors: Fifadara NH; Beer F; Ono S; Ono SJ
  • Actin-ADF/cofilin rod formation in Caenorhabditis elegans muscle requires a putative F-actin binding site of ADF/cofilin at the C-terminus.
    Cell Motil Cytoskeleton Volume: 66 Page(s): 398 - 408
    07/01/2009 Authors: Ono K; Ono S
  • Reconstitution of Connective Tissue Type Conjunctival Mast Cells in KitW-sh/W-sh Mice by Adoptive Transfer of Bone Marrow-Derived Cultured Mast Cells
    Volume: 123 Page(s): S128 - S128
    02/01/2009 Authors: Fukuda K; Ohbayashi M; Morohoshi K; Fifadara N; Kuo C; Ono SJ
  • Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans.
    J Cell Sci Volume: 121 Page(s): 3867 - 3877
    12/01/2008 Authors: Yamashiro S; Cox EA; Baillie DL; Hardin JD; Ono S
  • Caenorhabditis elegans gelsolin-like protein 1 is a novel actin filament-severing protein with four gelsolin-like repeats.
    J Biol Chem Volume: 283 Page(s): 26071 - 26080
    09/19/2008 Authors: Klaavuniemi T; Yamashiro S; Ono S
  • Essential role of ADF/cofilin for assembly of contractile actin networks in the C. elegans somatic gonad.
    J Cell Sci Volume: 121 Page(s): 2662 - 2670
    08/15/2008 Authors: Ono K; Yamashiro S; Ono S
  • UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
    J Cell Sci Volume: 120 Page(s): 3022 - 3033
    09/01/2007 Authors: Yamashiro S; Gimona M; Ono S
  • Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.
    Dev Dyn Volume: 236 Page(s): 1093 - 1105
    04/01/2007 Authors: Ono K; Yu R; Ono S
  • Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics.
    Int Rev Cytol Volume: 258 Page(s): 1 - 82
    01/01/2007 Authors: Ono S
  • Dual roles of tropomyosin as an F-actin stabilizer and a regulator of muscle contraction in Caenorhabditis elegans body wall muscle.
    Cell Motil Cytoskeleton Volume: 63 Page(s): 659 - 672
    11/01/2006 Authors: Yu R; Ono S
  • A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.
    Am J Hum Genet Volume: 78 Page(s): 947 - 960
    06/01/2006 Authors: Procaccio V; Salazar G; Ono S; Styers ML; Gearing M; Davila A; Jimenez R; Juncos J; Gutekunst C-A; Meroni G
  • Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.
    Mol Biol Cell Volume: 17 Page(s): 2722 - 2734
    06/01/2006 Authors: Ono K; Yu R; Mohri K; Ono S
  • Enhancement of actin-depolymerizing factor/cofilin-dependent actin disassembly by actin-interacting protein 1 is required for organized actin filament assembly in the Caenorhabditis elegans body wall muscle.
    Mol Biol Cell Volume: 17 Page(s): 2190 - 2199
    05/01/2006 Authors: Mohri K; Ono K; Yu R; Yamashiro S; Ono S
  • Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner.
    Cell Motil Cytoskeleton Volume: 63 Page(s): 14 - 28
    01/01/2006 Authors: Polet D; Lambrechts A; Ono K; Mah A; Peelman F; Vandekerckhove J; Baillie DL; Ampe C; Ono S
  • The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and depolymerization.
    Biochemistry Volume: 44 Page(s): 14238 - 14247
    11/01/2005 Authors: Yamashiro S; Mohri K; Ono S
  • Two mouse cofilin isoforms, muscle-type (MCF) and non-muscle type (NMCF), interact with F-actin with different efficiencies.
    J Biochem Volume: 138 Page(s): 519 - 526
    10/01/2005 Authors: Nakashima K; Sato N; Nakagaki T; Abe H; Ono S; Obinata T
  • Molecular and biochemical characterization of kettin in Caenorhabditis elegans.
    J Muscle Res Cell Motil Volume: 26 Page(s): 449 - 454
    01/01/2005 Authors: Ono S; Mohri K; Ono K
  • The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans.
    J Cell Biol Volume: 167 Page(s): 639 - 647
    11/22/2004 Authors: Anyanful A; Ono K; Johnsen RC; Ly H; Jensen V; Baillie DL; Ono S
  • Mutational analysis of C-elegans AIP1 (UNC-78) in disassembly of ADF/cofilin-bound actin filaments in vitro and actin cytoskeletal organization in vivo
    Volume: 15 Page(s): 384A - 384A
    11/01/2004 Authors: Mohri K; Yu R; Vorobiev S; Fedorov AA; Almo SC; Ono S
  • Inhibition of ADF/cofilin binding to actin filaments by UNC-87, a C-elegans calponin-repeat protein
    Volume: 15 Page(s): 384A - 384A
    11/01/2004 Authors: Yamashiro S; Woo JH; Gimona M; Ono S
  • TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats.
    Mol Biol Cell Volume: 15 Page(s): 4735 - 4748
    10/01/2004 Authors: Van Troys M; Ono K; Dewitte D; Jonckheere V; De Ruyck N; Vandekerckhove J; Ono S; Ampe C
  • Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments.
    J Biol Chem Volume: 279 Page(s): 31697 - 31707
    07/23/2004 Authors: Mohri K; Vorobiev S; Fedorov AA; Almo SC; Ono S
  • Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system.
    Mol Biol Cell Volume: 15 Page(s): 2782 - 2793
    06/01/2004 Authors: Ono K; Ono S
  • Microscopic evidence that actin-interacting protein 1 actively disassembles actin-depolymerizing factor/Cofilin-bound actin filaments.
    J Biol Chem Volume: 279 Page(s): 14207 - 14212
    04/02/2004 Authors: Ono S; Mohri K; Ono K
  • Actin brain aggregation in identical twins with dystonia and deafness: dysregulation of actin dynamics as a consequence of a bioenergetic defect
    Volume: 1657 Page(s): 44 - 45
    01/01/2004 Authors: Procaccio V; Gearing M; Ono S; Juncos J; Wallace D; Wainer B
  • Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform.
    J Cell Sci Volume: 116 Page(s): 4107 - 4118
    10/15/2003 Authors: Mohri K; Ono S
  • Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.
    J Cell Sci Volume: 116 Page(s): 2073 - 2085
    05/15/2003 Authors: Ono K; Parast M; Alberico C; Benian GM; Ono S
  • The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism.
    Proc Natl Acad Sci U S A Volume: 100 Page(s): 5760 - 5765
    05/13/2003 Authors: Vorobiev S; Strokopytov B; Drubin DG; Frieden C; Ono S; Condeelis J; Rubenstein PA; Almo SC
  • The distinct roles of ADF/cofilin isoforms, UNC-60A and UNC-60B, in C-elegans development
    Volume: 13 Page(s): 450A - 450A
    11/01/2002 Authors: Parast MM; Ono K; Aroian RV; Weeds AG; Ono S
  • Regulation of actin filament disassembly by UNC-78 (AIP1) and UNC-60B (ADF/cofilin) in C-elegans
    Volume: 13 Page(s): 450A - 451A
    11/01/2002 Authors: Mohri K; Weeds A; Ono S
  • Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia.
    Ann Neurol Volume: 52 Page(s): 465 - 476
    10/01/2002 Authors: Gearing M; Juncos JL; Procaccio V; Gutekunst C-A; Marino-Rodriguez EM; Gyure KA; Ono S; Santoianni R; Krawiecki NS; Wallace DC
  • Actin aggregation in identical twins with dystonia: Consequence of a defect in bioenergetics.
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY Volume: 61 Page(s): 460 - 460
    05/01/2002 Authors: Gearing M; Procaccio V; Ono S; Juncos JL; Wainer BH
  • Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics.
    J Cell Biol Volume: 156 Page(s): 1065 - 1076
    03/18/2002 Authors: Ono S; Ono K
  • Role of tropomyosin in maintaining stable actin cytoskeleton in C-elegans
    MOLECULAR BIOLOGY OF THE CELL Volume: 12 Page(s): 291A - 291A
    11/01/2001 Authors: Ono S; Ono K
  • UNC-78, a C-elegans homolog of actin-interacting protein 1, induces disassembly of actin filaments depending on stable association of ADF/cofilin with F-actin
    MOLECULAR BIOLOGY OF THE CELL Volume: 12 Page(s): 285A - 285A
    11/01/2001 Authors: Mohri K; Ono S
  • The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments.
    J Cell Biol Volume: 152 Page(s): 1313 - 1319
    03/19/2001 Authors: Ono S
  • The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site.
    J Biol Chem Volume: 276 Page(s): 5952 - 5958
    02/23/2001 Authors: Ono S; McGough A; Pope BJ; Tolbert VT; Bui A; Pohl J; Benian GM; Gernert KM; Weeds AG
  • Structural insights into the regulation of actin assembly by ADF/cofilin
    MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 176A - 176A
    12/01/2000 Authors: McGough A; Ono S; Pope B; Lappalainen P; Drubin D; Weeds A
  • The C-elegans unc-78 gene encodes an AIP1 homolog and is required for organized actin assembly into myofibrils.
    MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 185A - 185A
    12/01/2000 Authors: Ono S
  • Regulation of actin filament dynamics by ADF/cofilin (UNC-60B) and tropomyosin in C-elegans.
    MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 24A - 24A
    11/01/1999 Authors: Ono S; Mercer KB
  • Putting a new twist on actin: ADF/cofilins modulate actin dynamics.
    Trends Cell Biol Volume: 9 Page(s): 364 - 370
    09/01/1999 Authors: Bamburg JR; McGough A; Ono S
  • UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.
    J Cell Biol Volume: 145 Page(s): 491 - 502
    05/03/1999 Authors: Ono S; Baillie DL; Benian GM
  • Purification and biochemical characterization of actin from Caenorhabditis elegans: its difference from rabbit muscle actin in the interaction with nematode ADF/cofilin.
    Cell Motil Cytoskeleton Volume: 43 Page(s): 128 - 136
    01/01/1999 Authors: Ono S
  • Essential function of ADF/cofilin for actin assembly during myofibril formation in C-elegans.
    MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 16A - 16A
    11/01/1998 Authors: Ono S; Baillie DL; Benian GM
  • The crystal structure of human fascin.
    MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 384A - 384A
    11/01/1998 Authors: Fedorov AA; Fedorov L; Ono S; Matsumura F; Almo SC
  • Cofilin regulates actin dynamics by altering filament structure.
    MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 16A - 16A
    11/01/1998 Authors: McGough A; Chiu W; Drubin D; Lappalainen P; Ono S; Pope B; Weeds A
  • Regulatory roles of complexins in neurotransmitter release from mature presynaptic nerve terminals.
    Eur J Neurosci Volume: 10 Page(s): 2143 - 2152
    06/01/1998 Authors: Ono S; Baux G; Sekiguchi M; Fossier P; Morel NF; Nihonmatsu I; Hirata K; Awaji T; Takahashi S; Takahashi M
  • Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells.
    Mol Biol Cell Volume: 9 Page(s): 993 - 1006
    05/01/1998 Authors: Yamashiro S; Yamakita Y; Ono S; Matsumura F
  • Two Caenorhabditis elegans actin depolymerizing factor/cofilin proteins, encoded by the unc-60 gene, differentially regulate actin filament dynamics.
    J Biol Chem Volume: 273 Page(s): 3778 - 3783
    02/06/1998 Authors: Ono S; Benian GM
  • Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells.
    J Cell Biol Volume: 140 Page(s): 119 - 129
    01/12/1998 Authors: Matsumura F; Ono S; Yamakita Y; Totsukawa G; Yamashiro S
  • Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurite extension.
    Cell Motil Cytoskeleton Volume: 39 Page(s): 172 - 190
    01/01/1998 Authors: Meberg PJ; Ono S; Minamide LS; Takahashi M; Bamburg JR
  • Differential properties of two C-elegans ADF/cofilin proteins encoded by the UNC-60 gene.
    MOLECULAR BIOLOGY OF THE CELL Volume: 8 Page(s): 898 - 898
    11/01/1997 Authors: Ono S; Alberico C; Benian GM
  • Low molecular-weight G-actin binding proteins involved in the regulation of actin assembly during myofibrillogenesis.
    Cell Struct Funct Volume: 22 Page(s): 181 - 189
    02/01/1997 Authors: Obinata T; Nagaoka-Yasuda R; Ono S; Kusano K; Mohri K; Ohtaka Y; Yamashiro S; Okada K; Abe H
  • Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin.
    J Biol Chem Volume: 272 Page(s): 2527 - 2533
    01/24/1997 Authors: Ono S; Yamakita Y; Yamashiro S; Matsudaira PT; Gnarra JR; Obinata T; Matsumura F
  • Stimulus-dependent disorganization of actin filaments induced by overexpression of cofilin in C2 myoblasts.
    Cell Struct Funct Volume: 21 Page(s): 491 - 499
    12/01/1996 Authors: Ono S; Abe H; Obinata T
  • Disorganization of actin filaments induced by overexpression of cofilin in mammalian cultured cells.
    MOLECULAR BIOLOGY OF THE CELL Volume: 7 Page(s): 1175 - 1175
    12/01/1996 Authors: Ono S; Abe H; Obinata T
  • Differential assembly of cytoskeletal and sarcomeric actins in developing skeletal muscle cells in vitro.
    Zoolog Sci Volume: 13 Page(s): 509 - 517
    08/01/1996 Authors: Hayakawa K; Ono S; Nagaoka R; Saitoh O; Obinata T
  • Phosphorylation of human fascin inhibits its actin binding and bundling activities.
    J Biol Chem Volume: 271 Page(s): 12632 - 12638
    05/24/1996 Authors: Yamakita Y; Ono S; Matsumura F; Yamashiro S
  • Essential role of caldesmon in the actin filament reorganization induced by glucocorticoids.
    J Cell Biol Volume: 131 Page(s): 1223 - 1230
    12/01/1995 Authors: Castellino F; Ono S; Matsumura F; Luini A
  • Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle.
    J Biol Chem Volume: 269 Page(s): 15280 - 15286
    05/27/1994 Authors: Ono S; Minami N; Abe H; Obinata T
  • THE MOLECULAR-STRUCTURE OF MUSCLE-TYPE COFILIN AND ITS TISSUE EXPRESSION
    JOURNAL OF CELLULAR BIOCHEMISTRY Page(s): 510 - 510
    01/01/1994 Authors: OBINATA T; ABE H; MINAMI N; ONO S
  • Increased expression of cofilin in dystrophic chicken and mouse skeletal muscles.
    J Biochem Volume: 114 Page(s): 582 - 587
    10/01/1993 Authors: Hayakawa K; Minami N; Ono S; Ogasawara Y; Totsuka T; Abe H; Tanaka T; Obinata T
  • Colocalization of ADF and cofilin in intranuclear actin rods of cultured muscle cells.
    J Muscle Res Cell Motil Volume: 14 Page(s): 195 - 204
    04/01/1993 Authors: Ono S; Abe H; Nagaoka R; Obinata T
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