Sumin Kang PhD

Department of Hematology and Medical Oncology
Professor

Emory University
Hematology and Medical Oncology
1365C Clifton Rd NE, Winship Cancer Institute, Suite C3006

Academic Appointment

Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute

Education

Degrees

PhD from Yonsei University
MS from Yonsei University
BS from Seoul Women’s University

Research

Focus

Main Focus of my research focuses on phosphor-proteomics based studies to elucidate signaling mechanisms underlying protein kinase-dependent oncogenesis and tumor metastasis; translational and preclinical studies using in vitro cell assays and in vivo mouse models of tumors and metastases to evaluate small molecule protein kinase inhibitors to treat human cancers.

Publications

Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis.
Proc Natl Acad Sci U S A Volume: 120 Page(s): e2217332120
06/06/2023 Authors: Boese AC; Kang J; Hwang JS; Kim J; Eun K; Malin CM; Magliocca KR; Pan C; Jin L; Kang S
EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer.
Cell Rep Volume: 41 Page(s): 111827
12/13/2022 Authors: Kang J; Chun J; Hwang JS; Pan C; Li J; Boese AC; Young I; Malin CM; Kang Y; Gibbons DL
Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24.
Immunomedicine Volume: 2
12/01/2022 Authors: Boese AC; Hwang JS; Young I; Malin CM; Avalos V; Kang J; Kang S
Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1.
Nat Commun Volume: 12 Page(s): 4960
08/16/2021 Authors: Pan C; Kang J; Hwang JS; Li J; Boese AC; Wang X; Yang L; Boggon TJ; Chen GZ; Saba NF
Mitochondrial metabolism-mediated redox regulation in cancer progression.
Redox Biol Volume: 42 Page(s): 101870
06/01/2021 Authors: Boese AC; Kang S
A DGKA-cJUN-WEE1 signaling axis provides platinum resistance in ovarian cancer
Volume: 80
08/01/2020 Authors: Li J; Pan C; Boese AC; Umano A; Kang S
Hsp90B protects MAST1 from CHIP-mediated ubiquitination and degradation providing cisplatin resistance
Volume: 80
08/01/2020 Authors: Pan C; Li J; Boese A; Kang S
DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Clin Cancer Res Volume: 26 Page(s): 3843 - 3855
07/15/2020 Authors: Li J; Pan C; Boese AC; Kang J; Umano AD; Magliocca KR; Yang W; Zhang Y; Lonial S; Jin L
New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
J Thorac Oncol Volume: 15 Page(s): 520 - 540
04/01/2020 Authors: Poirier JT; George J; Owonikoko TK; Berns A; Brambilla E; Byers LA; Carbone D; Chen HJ; Christensen CL; Dive C
Tumor Progression of Breast Cancer during Hyperinsulinemic Obesity.
Trends Mol Med Volume: 26 Page(s): 354 - 356
04/01/2020 Authors: Boese AC; Kang S
Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
J Clin Invest Volume: 129 Page(s): 4110 - 4123
10/01/2019 Authors: Pan C; Chun J; Li D; Boese AC; Li J; Kang J; Umano A; Jiang Y; Song L; Magliocca KR
Metabolic product of inositol-trisphosphate 3-kinase B confers chemotherapy resistance by managing redox homeostasis
Volume: 79
07/01/2019 Authors: Pan C; Chun J; Boese A; Kang J; Li J; Jin L; Kang S
Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.
J Clin Invest Volume: 129 Page(s): 2431 - 2445
05/13/2019 Authors: Pan C; Jin L; Wang X; Li Y; Chun J; Boese AC; Li D; Kang H-B; Zhang G; Zhou L
Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression.
Nat Metab Volume: 1 Page(s): 390 - 403
03/01/2019 Authors: Ni F; Yu W-M; Li Z; Graham DK; Jin L; Kang S; Rossi MR; Li S; Broxmeyer HE; Qu C-K
Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.
Sci Adv Volume: 4 Page(s): eaat2681
10/01/2018 Authors: Zheng H; Yu W-M; Shen J; Kang S; Hambardzumyan D; Li JY; Shen Y; Kenney AM; Chen J; Qu C-K
MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation.
Cancer Cell Volume: 34 Page(s): 315 - 330.e7
02/01/2018 Authors: Jin L; Chun J; Pan C; Li D; Lin R; Alesi GN; Wang X; Kang H-B; Song L; Wang D
Glutamate dehydrogenase 1 mediates metabolic reprogramming and promotes tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer
Volume: 78
07/01/2018 Authors: Kang S; Jin L; Pan C; Chun J
A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
FASEB J Volume: 32 Page(s): 875 - 887
02/01/2018 Authors: Wang L; Iorio C; Yan K; Yang H; Takeshita S; Kang S; Neel BG; Yang W
The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
Mol Cell Volume: 69 Page(s): 87 - 99.e7
01/04/2018 Authors: Jin L; Chun J; Pan C; Kumar A; Zhang G; Ha Y; Li D; Alesi GN; Kang Y; Zhou L
Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
Oncogene Volume: 36 Page(s): 3797 - 3806
07/06/2017 Authors: Jin L; Chun J; Pan C; Alesi GN; Li D; Magliocca KR; Kang Y; Chen ZG; Shin DM; Khuri FR
Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Mol Cell Volume: 64 Page(s): 859 - 874
12/01/2016 Authors: Fan J; Lin R; Xia S; Chen D; Elf SE; Liu S; Pan Y; Xu H; Qian Z; Wang M
RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
Oncogene Volume: 35 Page(s): 5412 - 5421
10/13/2016 Authors: Alesi GN; Jin L; Li D; Magliocca KR; Kang Y; Chen ZG; Shin DM; Khuri FR; Kang S
Glutaminolysis as a target for cancer therapy.
Oncogene Volume: 35 Page(s): 3619 - 3625
07/14/2016 Authors: Jin L; Alesi GN; Kang S
RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis
Volume: 76
04/01/2016 Authors: Alesi G; Jin L; Li D; Magliocca K; Kang Y; Chen ZG; Shin DM; Khuri FR; Kang S
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Nat Cell Biol Volume: 17 Page(s): 1484 - 1496
11/01/2015 Authors: Lin R; Elf S; Shan C; Kang H-B; Ji Q; Zhou L; Hitosugi T; Zhang L; Zhang S; Seo JH
Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.
Mol Cell Volume: 59 Page(s): 345 - 358
08/06/2015 Authors: Kang H-B; Fan J; Lin R; Elf S; Ji Q; Zhao L; Jin L; Seo JH; Shan C; Arbiser JL
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth
Volume: 75
08/01/2015 Authors: Jin L; Li D; Alesi G; Fan J; Kang H-B; Zhou L; Boggon T; Magliocca K; He C; Arellano M
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
Cancer Cell Volume: 27 Page(s): 257 - 270
02/09/2015 Authors: Jin L; Li D; Alesi GN; Fan J; Kang H-B; Lu Z; Boggon TJ; Jin P; Yi H; Wright ER
6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling
Volume: 74
10/01/2014 Authors: Shan C; Elf SE; Gu T-L; Khoury HJ; Boggon T; Kang S; Chen J
Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect
Volume: 74
10/01/2014 Authors: Fan J; Gu T-L; Boggon T; Kang S; Chen J
RSK2-mediated phosphorylation of stathmin promotes microtubule polymerization, providing a pro-invasive advantage to metastatic cancer cells
Volume: 74
10/01/2014 Authors: Alesi G; Li D; Jin L; Chen GZ; Shin DM; Khuri F; Kang S
Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.
J Biol Chem Volume: 289 Page(s): 26533 - 26541
09/19/2014 Authors: Fan J; Kang H-B; Shan C; Elf S; Lin R; Xie J; Gu T-L; Aguiar M; Lonning S; Chung T-W
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Mol Cell Volume: 55 Page(s): 552 - 565
08/21/2014 Authors: Shan C; Elf S; Ji Q; Kang H-B; Zhou L; Hitosugi T; Jin L; Lin R; Zhang L; Seo JH
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
Mol Cell Volume: 53 Page(s): 534 - 548
02/20/2014 Authors: Fan J; Shan C; Kang H-B; Elf S; Xie J; Tucker M; Gu T-L; Aguiar M; Lonning S; Chen H
The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis.
J Biol Chem Volume: 288 Page(s): 32528 - 32538
11/08/2013 Authors: Li D; Jin L; Alesi GN; Kim Y-M; Fan J; Seo JH; Wang D; Tucker M; Gu T-L; Lee BH
p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.
Mol Cell Biol Volume: 33 Page(s): 2574 - 2585
07/01/2013 Authors: Jin L; Li D; Lee JS; Elf S; Alesi GN; Fan J; Kang H-B; Wang D; Fu H; Taunton J
p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis.
Volume: 73
04/15/2013 Authors: Jin L; Li D; Lee J; Alesi GN; Fan J; Kang H-B; Wang D; Fu H; Taunton J; Boggon TJ
RSK2/CREB/Fascin-1 signaling is important for tumor metastasis.
Volume: 73
04/15/2013 Authors: Li D; Jin L; Alesi G; Kim YM; Wang D; Lee BH; Taunton J; Magliocca KR; Chen ZG; Kang S
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Nat Commun Volume: 4 Page(s): 1790
01/01/2013 Authors: Hitosugi T; Zhou L; Fan J; Elf S; Zhang L; Xie J; Wang Y; Gu T-L; Alekovi M; LeRoy G
Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors.
J Am Chem Soc Volume: 134 Page(s): 20214 - 20217
12/19/2012 Authors: Gushwa NN; Kang S; Chen J; Taunton J
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Cancer Cell Volume: 22 Page(s): 585 - 600
11/13/2012 Authors: Hitosugi T; Zhou L; Elf S; Fan J; Kang H-B; Seo JH; Shan C; Dai Q; Zhang L; Xie J
RSK2 mediates anti-anoikis signals by regulating downstream factors through both transcription -independent and -dependent manner in human cancers
CANCER RESEARCH Volume: 72
04/15/2012 Authors: Lee JS; Jin L; Li D; Kim LS; Taunton J; Chen GZ; Shin DM; Kang S
Oncogenic tyrosine kinases are localized to mitochondria and regulate cancer metabolism by phosphorylating key components of pyruvate dehydrogenase kinase complex
CANCER RESEARCH Volume: 72
04/15/2012 Authors: Chen J; Hitosugi T; Fan J; Kang S; Gu T-L; Boggon T
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
Mol Cell Volume: 44 Page(s): 864 - 877
12/23/2011 Authors: Hitosugi T; Fan J; Chung T-W; Lythgoe K; Wang X; Xie J; Ge Q; Gu T-L; Polakiewicz RD; Roesel JL
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
Mol Cell Biol Volume: 31 Page(s): 4938 - 4950
12/01/2011 Authors: Fan J; Hitosugi T; Chung T-W; Xie J; Ge Q; Gu T-L; Polakiewicz RD; Chen GZ; Boggon TJ; Lonial S
Targeting RSK2 in myeloid leukemia: right for FLT3 but wrong for BCR-ABL.
Cell Cycle Volume: 10 Page(s): 3611 - 3612
11/01/2011 Authors: Lee BH; Kang S
p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
Blood Volume: 117 Page(s): 6885 - 6894
06/23/2011 Authors: Elf S; Blevins D; Jin L; Chung T-W; Williams IR; Lee BH; Lin J-X; Leonard WJ; Taunton J; Khoury HJ
Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Fan J; Hitosugi T; Chung T-W; Wang X; Gu T-L; Roesel JL; Chen ZG; Boggon T; Khuri FR; Kang S
Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Fan J; Hitosugi T; Chung T-W; Wang X; Gu T-L; Roesel JL; Chen ZG; Boggon T; Khuri FR; Kang S
RSK2 phosphorylates and activates CREB to promote HNSCC cell invasion through upregulation of pro-metastatic MCAM and Fascin-1
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Jin L; Kim Y-M; Zhou W; Taunton J; Chen GZ; Shin DM; Khuri FR; Kang S
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
CANCER RESEARCH Volume: 71
04/15/2011 Authors: Chung T-W; Hitosugi T; Fan J; Wang X; Gu T-L; Roesei JL; Boggon T; Chen ZG; Khuri FR; Kang S
Targeting RSK2 in human malignancies.
Expert Opin Ther Targets Volume: 15 Page(s): 11 - 20
01/01/2011 Authors: Kang S; Chen J
Constitutively active FGFR3 with Lys650Glu mutation enhances bortezomib sensitivity in plasma cell malignancy.
Anticancer Res Volume: 31 Page(s): 113 - 122
01/01/2011 Authors: Otsuka M; Mizuki M; Fujita J; Kang S; Kanakura Y
ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1.
J Biol Chem Volume: 285 Page(s): 41310 - 41319
12/31/2010 Authors: Oh Y-T; Liu X; Yue P; Kang S; Chen J; Taunton J; Khuri FR; Sun S-Y
Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth
Volume: 116 Page(s): 1294 - 1294
11/19/2010 Authors: Hitosugi T; Kang S; Vander Heiden M; Chung T-W; Elf S; Lythgoe K; Dong S; Lonial S; Wang X; Chen G
p90RSK2 Is Essential for FLT3-ITD-, but Dispensable for BCR-ABL-Induced Myeloid Leukemia.
Volume: 116 Page(s): 718 - 719
11/19/2010 Authors: Elf S; Chung T-W; Blevins DP; Williams I; Khoury HJ; Taunton J; Kang S
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
J Clin Invest Volume: 120 Page(s): 1165 - 1177
04/01/2010 Authors: Kang S; Elf S; Lythgoe K; Hitosugi T; Taunton J; Zhou W; Xiong L; Wang D; Muller S; Fan S
Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth
Volume: 70
04/01/2010 Authors: Hitosugi T; Kang S; Heiden MGV; Chung T-W; Lonial S; Wang X; Chen GZ; Xie J; Gu T-L; Polakiewicz RD
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Sci Signal Volume: 2 Page(s): ra73
11/17/2009 Authors: Hitosugi T; Kang S; Vander Heiden MG; Chung T-W; Elf S; Lythgoe K; Dong S; Lonial S; Wang X; Chen GZ
NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association.
Oncogene Volume: 28 Page(s): 3825 - 3836
10/29/2009 Authors: Chan CB; Liu X; Jang S-W; Hsu SI-H; Williams I; Kang S; Chen J; Ye K
Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase.
Biochem Biophys Res Commun Volume: 386 Page(s): 55 - 59
08/14/2009 Authors: Kang S-M; Choi J-K; Kim S-J; Kim J-H; Ahn D-G; Oh J-W
Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis.
Cancer Lett Volume: 279 Page(s): 230 - 237
07/08/2009 Authors: Kang S-M; Kim S-J; Kim J-H; Lee W; Kim G-W; Lee K-H; Choi K-Y; Oh J-W
Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
Mol Cell Biol Volume: 29 Page(s): 2105 - 2117
04/01/2009 Authors: Kang S; Elf S; Dong S; Hitosugi T; Lythgoe K; Guo A; Ruan H; Lonial S; Khoury HJ; Williams IR
FGFR3 Associates with and Tyrosine-Phosphorylates p90RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation
Volume: 112 Page(s): 1276 - 1276
11/16/2008 Authors: Kang S; Elf S; Dong S; Hitosugi T; Guo A; Ruan H; Lonial S; Khoury H; Williams I; Karsenty G
Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070.
Leukemia Volume: 22 Page(s): 572 - 577
03/01/2008 Authors: Dong S; Kang S; Lonial S; Khoury HJ; Viallet J; Chen J
Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.
J Biol Chem Volume: 283 Page(s): 4652 - 4657
02/22/2008 Authors: Kang S; Dong S; Guo A; Ruan H; Lonial S; Khoury HJ; Gu T-L; Chen J
Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and BCl-2 inhibitor GX15-070
Volume: 110 Page(s): 858A - 859A
11/16/2007 Authors: Dong S; Kang S; Lonial S; Khoury HJ; Viallet J; Chen J
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
Cancer Cell Volume: 12 Page(s): 201 - 214
09/01/2007 Authors: Kang S; Dong S; Gu T-L; Guo A; Cohen MS; Lonial S; Khoury HJ; Fabbro D; Gilliland DG; Bergsagel PL
14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.
Blood Volume: 110 Page(s): 360 - 369
07/01/2007 Authors: Dong S; Kang S; Gu T-L; Kardar S; Fu H; Lonial S; Khoury HJ; Khuri F; Chen J
Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival.
Proc Natl Acad Sci U S A Volume: 104 Page(s): 9679 - 9684
06/05/2007 Authors: Liu X; Liu Z; Jang S-W; Ma Z; Shinmura K; Kang S; Dong S; Chen J; Fukasawa K; Ye K
14-3-3 integrates pro-survival signals in hematopoietic cells transformed by diverse leukemogenic tyrosine kinases, and represents a common target.
Volume: 108 Page(s): 337A - 337A
11/16/2006 Authors: Dong S; Kang S; Gu T-L; Kardar S; Lonial S; Khoury HJ; Khuri F; Fu H; Chen J
FGFR3 activates RSK2 to mediate hematopoietic transformation through both tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
Volume: 108 Page(s): 155A - 156A
11/16/2006 Authors: Kang S; Dong S; Gu T-L; Cohen MS; Lonial S; Khoury HJ; Gillilattd DG; Taunton J; Polakiewicz RD; Chen J
Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.
Proteomics Volume: 5 Page(s): 2227 - 2237
05/01/2005 Authors: Kang S-M; Shin M-J; Kim J-H; Oh J-W
Bacterial cell surface display for epitope mapping of hepatitis C virus core antigen.
FEMS Microbiol Lett Volume: 226 Page(s): 347 - 353
09/26/2003 Authors: Kang S-M; Rhee J-K; Kim E-J; Han K-H; Oh J-W

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Sumin Kang PhD

Academic Appointment

Education

Degrees

Research

Focus

Publications