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Profile

Sumin Kang PhD

  • Department of Hematology and Medical Oncology
    Professor
  • (404) 778-1880
  • smkang@emory.edu
  • Kang lab website
  • Emory University
    Hematology and Medical Oncology
    1365C Clifton Rd NE, Winship Cancer Institute, Suite C3006
Head shot of Sumin Kang

Academic Appointment

  • Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute

Education

Degrees

  • PhD from Yonsei University
  • MS from Yonsei University
  • BS from Seoul Women’s University

Research

Focus

  • Main Focus of my research focuses on phosphor-proteomics based studies to elucidate signaling mechanisms underlying protein kinase-dependent oncogenesis and tumor metastasis; translational and preclinical studies using in vitro cell assays and in vivo mouse models of tumors and metastases to evaluate small molecule protein kinase inhibitors to treat human cancers.

Publications

  • Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis.
    Proc Natl Acad Sci U S A Volume: 120 Page(s): e2217332120
    06/06/2023 Authors: Boese AC; Kang J; Hwang JS; Kim J; Eun K; Malin CM; Magliocca KR; Pan C; Jin L; Kang S
  • EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer.
    Cell Rep Volume: 41 Page(s): 111827
    12/13/2022 Authors: Kang J; Chun J; Hwang JS; Pan C; Li J; Boese AC; Young I; Malin CM; Kang Y; Gibbons DL
  • Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24.
    Immunomedicine Volume: 2
    12/01/2022 Authors: Boese AC; Hwang JS; Young I; Malin CM; Avalos V; Kang J; Kang S
  • Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1.
    Nat Commun Volume: 12 Page(s): 4960
    08/16/2021 Authors: Pan C; Kang J; Hwang JS; Li J; Boese AC; Wang X; Yang L; Boggon TJ; Chen GZ; Saba NF
  • Mitochondrial metabolism-mediated redox regulation in cancer progression.
    Redox Biol Volume: 42 Page(s): 101870
    06/01/2021 Authors: Boese AC; Kang S
  • A DGKA-cJUN-WEE1 signaling axis provides platinum resistance in ovarian cancer
    Volume: 80
    08/01/2020 Authors: Li J; Pan C; Boese AC; Umano A; Kang S
  • Hsp90B protects MAST1 from CHIP-mediated ubiquitination and degradation providing cisplatin resistance
    Volume: 80
    08/01/2020 Authors: Pan C; Li J; Boese A; Kang S
  • DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
    Clin Cancer Res Volume: 26 Page(s): 3843 - 3855
    07/15/2020 Authors: Li J; Pan C; Boese AC; Kang J; Umano AD; Magliocca KR; Yang W; Zhang Y; Lonial S; Jin L
  • New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
    J Thorac Oncol Volume: 15 Page(s): 520 - 540
    04/01/2020 Authors: Poirier JT; George J; Owonikoko TK; Berns A; Brambilla E; Byers LA; Carbone D; Chen HJ; Christensen CL; Dive C
  • Tumor Progression of Breast Cancer during Hyperinsulinemic Obesity.
    Trends Mol Med Volume: 26 Page(s): 354 - 356
    04/01/2020 Authors: Boese AC; Kang S
  • Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
    J Clin Invest Volume: 129 Page(s): 4110 - 4123
    10/01/2019 Authors: Pan C; Chun J; Li D; Boese AC; Li J; Kang J; Umano A; Jiang Y; Song L; Magliocca KR
  • Metabolic product of inositol-trisphosphate 3-kinase B confers chemotherapy resistance by managing redox homeostasis
    Volume: 79
    07/01/2019 Authors: Pan C; Chun J; Boese A; Kang J; Li J; Jin L; Kang S
  • Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.
    J Clin Invest Volume: 129 Page(s): 2431 - 2445
    05/13/2019 Authors: Pan C; Jin L; Wang X; Li Y; Chun J; Boese AC; Li D; Kang H-B; Zhang G; Zhou L
  • Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression.
    Nat Metab Volume: 1 Page(s): 390 - 403
    03/01/2019 Authors: Ni F; Yu W-M; Li Z; Graham DK; Jin L; Kang S; Rossi MR; Li S; Broxmeyer HE; Qu C-K
  • Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.
    Sci Adv Volume: 4 Page(s): eaat2681
    10/01/2018 Authors: Zheng H; Yu W-M; Shen J; Kang S; Hambardzumyan D; Li JY; Shen Y; Kenney AM; Chen J; Qu C-K
  • MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation.
    Cancer Cell Volume: 34 Page(s): 315 - 330.e7
    02/01/2018 Authors: Jin L; Chun J; Pan C; Li D; Lin R; Alesi GN; Wang X; Kang H-B; Song L; Wang D
  • Glutamate dehydrogenase 1 mediates metabolic reprogramming and promotes tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer
    Volume: 78
    07/01/2018 Authors: Kang S; Jin L; Pan C; Chun J
  • A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
    FASEB J Volume: 32 Page(s): 875 - 887
    02/01/2018 Authors: Wang L; Iorio C; Yan K; Yang H; Takeshita S; Kang S; Neel BG; Yang W
  • The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.
    Mol Cell Volume: 69 Page(s): 87 - 99.e7
    01/04/2018 Authors: Jin L; Chun J; Pan C; Kumar A; Zhang G; Ha Y; Li D; Alesi GN; Kang Y; Zhou L
  • Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
    Oncogene Volume: 36 Page(s): 3797 - 3806
    07/06/2017 Authors: Jin L; Chun J; Pan C; Alesi GN; Li D; Magliocca KR; Kang Y; Chen ZG; Shin DM; Khuri FR
  • Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
    Mol Cell Volume: 64 Page(s): 859 - 874
    12/01/2016 Authors: Fan J; Lin R; Xia S; Chen D; Elf SE; Liu S; Pan Y; Xu H; Qian Z; Wang M
  • RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis.
    Oncogene Volume: 35 Page(s): 5412 - 5421
    10/13/2016 Authors: Alesi GN; Jin L; Li D; Magliocca KR; Kang Y; Chen ZG; Shin DM; Khuri FR; Kang S
  • Glutaminolysis as a target for cancer therapy.
    Oncogene Volume: 35 Page(s): 3619 - 3625
    07/14/2016 Authors: Jin L; Alesi GN; Kang S
  • RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis
    Volume: 76
    04/01/2016 Authors: Alesi G; Jin L; Li D; Magliocca K; Kang Y; Chen ZG; Shin DM; Khuri FR; Kang S
  • 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nat Cell Biol Volume: 17 Page(s): 1484 - 1496
    11/01/2015 Authors: Lin R; Elf S; Shan C; Kang H-B; Ji Q; Zhou L; Hitosugi T; Zhang L; Zhang S; Seo JH
  • Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.
    Mol Cell Volume: 59 Page(s): 345 - 358
    08/06/2015 Authors: Kang H-B; Fan J; Lin R; Elf S; Ji Q; Zhao L; Jin L; Seo JH; Shan C; Arbiser JL
  • Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth
    Volume: 75
    08/01/2015 Authors: Jin L; Li D; Alesi G; Fan J; Kang H-B; Zhou L; Boggon T; Magliocca K; He C; Arellano M
  • Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
    Cancer Cell Volume: 27 Page(s): 257 - 270
    02/09/2015 Authors: Jin L; Li D; Alesi GN; Fan J; Kang H-B; Lu Z; Boggon TJ; Jin P; Yi H; Wright ER
  • 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling
    Volume: 74
    10/01/2014 Authors: Shan C; Elf SE; Gu T-L; Khoury HJ; Boggon T; Kang S; Chen J
  • Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect
    Volume: 74
    10/01/2014 Authors: Fan J; Gu T-L; Boggon T; Kang S; Chen J
  • RSK2-mediated phosphorylation of stathmin promotes microtubule polymerization, providing a pro-invasive advantage to metastatic cancer cells
    Volume: 74
    10/01/2014 Authors: Alesi G; Li D; Jin L; Chen GZ; Shin DM; Khuri F; Kang S
  • Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.
    J Biol Chem Volume: 289 Page(s): 26533 - 26541
    09/19/2014 Authors: Fan J; Kang H-B; Shan C; Elf S; Lin R; Xie J; Gu T-L; Aguiar M; Lonning S; Chung T-W
  • Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
    Mol Cell Volume: 55 Page(s): 552 - 565
    08/21/2014 Authors: Shan C; Elf S; Ji Q; Kang H-B; Zhou L; Hitosugi T; Jin L; Lin R; Zhang L; Seo JH
  • Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
    Mol Cell Volume: 53 Page(s): 534 - 548
    02/20/2014 Authors: Fan J; Shan C; Kang H-B; Elf S; Xie J; Tucker M; Gu T-L; Aguiar M; Lonning S; Chen H
  • The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis.
    J Biol Chem Volume: 288 Page(s): 32528 - 32538
    11/08/2013 Authors: Li D; Jin L; Alesi GN; Kim Y-M; Fan J; Seo JH; Wang D; Tucker M; Gu T-L; Lee BH
  • p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.
    Mol Cell Biol Volume: 33 Page(s): 2574 - 2585
    07/01/2013 Authors: Jin L; Li D; Lee JS; Elf S; Alesi GN; Fan J; Kang H-B; Wang D; Fu H; Taunton J
  • p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis.
    Volume: 73
    04/15/2013 Authors: Jin L; Li D; Lee J; Alesi GN; Fan J; Kang H-B; Wang D; Fu H; Taunton J; Boggon TJ
  • RSK2/CREB/Fascin-1 signaling is important for tumor metastasis.
    Volume: 73
    04/15/2013 Authors: Li D; Jin L; Alesi G; Kim YM; Wang D; Lee BH; Taunton J; Magliocca KR; Chen ZG; Kang S
  • Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
    Nat Commun Volume: 4 Page(s): 1790
    01/01/2013 Authors: Hitosugi T; Zhou L; Fan J; Elf S; Zhang L; Xie J; Wang Y; Gu T-L; Alekovi M; LeRoy G
  • Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors.
    J Am Chem Soc Volume: 134 Page(s): 20214 - 20217
    12/19/2012 Authors: Gushwa NN; Kang S; Chen J; Taunton J
  • Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
    Cancer Cell Volume: 22 Page(s): 585 - 600
    11/13/2012 Authors: Hitosugi T; Zhou L; Elf S; Fan J; Kang H-B; Seo JH; Shan C; Dai Q; Zhang L; Xie J
  • RSK2 mediates anti-anoikis signals by regulating downstream factors through both transcription -independent and -dependent manner in human cancers
    CANCER RESEARCH Volume: 72
    04/15/2012 Authors: Lee JS; Jin L; Li D; Kim LS; Taunton J; Chen GZ; Shin DM; Kang S
  • Oncogenic tyrosine kinases are localized to mitochondria and regulate cancer metabolism by phosphorylating key components of pyruvate dehydrogenase kinase complex
    CANCER RESEARCH Volume: 72
    04/15/2012 Authors: Chen J; Hitosugi T; Fan J; Kang S; Gu T-L; Boggon T
  • Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
    Mol Cell Volume: 44 Page(s): 864 - 877
    12/23/2011 Authors: Hitosugi T; Fan J; Chung T-W; Lythgoe K; Wang X; Xie J; Ge Q; Gu T-L; Polakiewicz RD; Roesel JL
  • Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
    Mol Cell Biol Volume: 31 Page(s): 4938 - 4950
    12/01/2011 Authors: Fan J; Hitosugi T; Chung T-W; Xie J; Ge Q; Gu T-L; Polakiewicz RD; Chen GZ; Boggon TJ; Lonial S
  • Targeting RSK2 in myeloid leukemia: right for FLT3 but wrong for BCR-ABL.
    Cell Cycle Volume: 10 Page(s): 3611 - 3612
    11/01/2011 Authors: Lee BH; Kang S
  • p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
    Blood Volume: 117 Page(s): 6885 - 6894
    06/23/2011 Authors: Elf S; Blevins D; Jin L; Chung T-W; Williams IR; Lee BH; Lin J-X; Leonard WJ; Taunton J; Khoury HJ
  • Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth
    CANCER RESEARCH Volume: 71
    04/15/2011 Authors: Fan J; Hitosugi T; Chung T-W; Wang X; Gu T-L; Roesel JL; Chen ZG; Boggon T; Khuri FR; Kang S
  • Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth
    CANCER RESEARCH Volume: 71
    04/15/2011 Authors: Fan J; Hitosugi T; Chung T-W; Wang X; Gu T-L; Roesel JL; Chen ZG; Boggon T; Khuri FR; Kang S
  • RSK2 phosphorylates and activates CREB to promote HNSCC cell invasion through upregulation of pro-metastatic MCAM and Fascin-1
    CANCER RESEARCH Volume: 71
    04/15/2011 Authors: Jin L; Kim Y-M; Zhou W; Taunton J; Chen GZ; Shin DM; Khuri FR; Kang S
  • Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
    CANCER RESEARCH Volume: 71
    04/15/2011 Authors: Chung T-W; Hitosugi T; Fan J; Wang X; Gu T-L; Roesei JL; Boggon T; Chen ZG; Khuri FR; Kang S
  • Targeting RSK2 in human malignancies.
    Expert Opin Ther Targets Volume: 15 Page(s): 11 - 20
    01/01/2011 Authors: Kang S; Chen J
  • Constitutively active FGFR3 with Lys650Glu mutation enhances bortezomib sensitivity in plasma cell malignancy.
    Anticancer Res Volume: 31 Page(s): 113 - 122
    01/01/2011 Authors: Otsuka M; Mizuki M; Fujita J; Kang S; Kanakura Y
  • ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1.
    J Biol Chem Volume: 285 Page(s): 41310 - 41319
    12/31/2010 Authors: Oh Y-T; Liu X; Yue P; Kang S; Chen J; Taunton J; Khuri FR; Sun S-Y
  • Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth
    Volume: 116 Page(s): 1294 - 1294
    11/19/2010 Authors: Hitosugi T; Kang S; Vander Heiden M; Chung T-W; Elf S; Lythgoe K; Dong S; Lonial S; Wang X; Chen G
  • p90RSK2 Is Essential for FLT3-ITD-, but Dispensable for BCR-ABL-Induced Myeloid Leukemia.
    Volume: 116 Page(s): 718 - 719
    11/19/2010 Authors: Elf S; Chung T-W; Blevins DP; Williams I; Khoury HJ; Taunton J; Kang S
  • p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
    J Clin Invest Volume: 120 Page(s): 1165 - 1177
    04/01/2010 Authors: Kang S; Elf S; Lythgoe K; Hitosugi T; Taunton J; Zhou W; Xiong L; Wang D; Muller S; Fan S
  • Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth
    Volume: 70
    04/01/2010 Authors: Hitosugi T; Kang S; Heiden MGV; Chung T-W; Lonial S; Wang X; Chen GZ; Xie J; Gu T-L; Polakiewicz RD
  • Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
    Sci Signal Volume: 2 Page(s): ra73
    11/17/2009 Authors: Hitosugi T; Kang S; Vander Heiden MG; Chung T-W; Elf S; Lythgoe K; Dong S; Lonial S; Wang X; Chen GZ
  • NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association.
    Oncogene Volume: 28 Page(s): 3825 - 3836
    10/29/2009 Authors: Chan CB; Liu X; Jang S-W; Hsu SI-H; Williams I; Kang S; Chen J; Ye K
  • Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase.
    Biochem Biophys Res Commun Volume: 386 Page(s): 55 - 59
    08/14/2009 Authors: Kang S-M; Choi J-K; Kim S-J; Kim J-H; Ahn D-G; Oh J-W
  • Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis.
    Cancer Lett Volume: 279 Page(s): 230 - 237
    07/08/2009 Authors: Kang S-M; Kim S-J; Kim J-H; Lee W; Kim G-W; Lee K-H; Choi K-Y; Oh J-W
  • Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
    Mol Cell Biol Volume: 29 Page(s): 2105 - 2117
    04/01/2009 Authors: Kang S; Elf S; Dong S; Hitosugi T; Lythgoe K; Guo A; Ruan H; Lonial S; Khoury HJ; Williams IR
  • FGFR3 Associates with and Tyrosine-Phosphorylates p90RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation
    Volume: 112 Page(s): 1276 - 1276
    11/16/2008 Authors: Kang S; Elf S; Dong S; Hitosugi T; Guo A; Ruan H; Lonial S; Khoury H; Williams I; Karsenty G
  • Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070.
    Leukemia Volume: 22 Page(s): 572 - 577
    03/01/2008 Authors: Dong S; Kang S; Lonial S; Khoury HJ; Viallet J; Chen J
  • Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.
    J Biol Chem Volume: 283 Page(s): 4652 - 4657
    02/22/2008 Authors: Kang S; Dong S; Guo A; Ruan H; Lonial S; Khoury HJ; Gu T-L; Chen J
  • Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and BCl-2 inhibitor GX15-070
    Volume: 110 Page(s): 858A - 859A
    11/16/2007 Authors: Dong S; Kang S; Lonial S; Khoury HJ; Viallet J; Chen J
  • FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
    Cancer Cell Volume: 12 Page(s): 201 - 214
    09/01/2007 Authors: Kang S; Dong S; Gu T-L; Guo A; Cohen MS; Lonial S; Khoury HJ; Fabbro D; Gilliland DG; Bergsagel PL
  • 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.
    Blood Volume: 110 Page(s): 360 - 369
    07/01/2007 Authors: Dong S; Kang S; Gu T-L; Kardar S; Fu H; Lonial S; Khoury HJ; Khuri F; Chen J
  • Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival.
    Proc Natl Acad Sci U S A Volume: 104 Page(s): 9679 - 9684
    06/05/2007 Authors: Liu X; Liu Z; Jang S-W; Ma Z; Shinmura K; Kang S; Dong S; Chen J; Fukasawa K; Ye K
  • 14-3-3 integrates pro-survival signals in hematopoietic cells transformed by diverse leukemogenic tyrosine kinases, and represents a common target.
    Volume: 108 Page(s): 337A - 337A
    11/16/2006 Authors: Dong S; Kang S; Gu T-L; Kardar S; Lonial S; Khoury HJ; Khuri F; Fu H; Chen J
  • FGFR3 activates RSK2 to mediate hematopoietic transformation through both tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
    Volume: 108 Page(s): 155A - 156A
    11/16/2006 Authors: Kang S; Dong S; Gu T-L; Cohen MS; Lonial S; Khoury HJ; Gillilattd DG; Taunton J; Polakiewicz RD; Chen J
  • Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.
    Proteomics Volume: 5 Page(s): 2227 - 2237
    05/01/2005 Authors: Kang S-M; Shin M-J; Kim J-H; Oh J-W
  • Bacterial cell surface display for epitope mapping of hepatitis C virus core antigen.
    FEMS Microbiol Lett Volume: 226 Page(s): 347 - 353
    09/26/2003 Authors: Kang S-M; Rhee J-K; Kim E-J; Han K-H; Oh J-W
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