Steven Liang
- Department of Radiology and Imaging Sciences
Associate Professor
Overview
Dr. Steven Liang comes to Emory Radiology from Harvard University and Massachusetts General Hospital, where he was Associate Professor and Director of Radiochemistry and Biomarker Development, in the Division of Nuclear Medicine and Molecular Imaging. He has completed the Society of Nuclear Medicine and Molecular Imaging Future Leaders Academy, and has received numerous honors, including the Distinguished Investigator, Academy for Radiology and Biomedical Imaging Research, the Hal O'Brien Rising Star Award, the OKeanos-CAPA Young Investigator Award, RPSC SNMMI Young Investigator Award, and the Emory 1% Award. He received his PhD from the University of British Columbia and completed a post-doctoral fellowship with EJ Corey at Harvard University supported by the Natural Sciences and Engineering Research Council of Canada.
Academic Appointment
- Head, Emory Positron Emission Tomography Imaging Center, Emory University School of Medicine
- Associate Professor of Radiology and Imaging Sciences and Chemistry, Emory University School of Medicine
- Endowed Directorship of Radiochemistry, Cyclotron Facility and Radiopharmacy, Emory University School of Medicine
- Director, Radiopharmaceutical Discovery Laboratory, Emory University School of Medicine
Education
Degrees
- PhD from University of British Columbia
Research
Publications
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Diagnostic performance of [18F]FAPI-04 PET/CT in suspected recurrent hepatocellular carcinoma: prospective comparison with contrast-enhanced CT/MRI.
Eur J Nucl Med Mol Imaging
04/15/2025 Authors: Liang J; Weng S; Zhang J; Jiang S; Li W; Li S; Rong J; Liu H; Chen H; Liu Z -
Novel Cyclic Peptides as Interleukin-23 Inhibitor for Treating Inflammatory Disorders.
ACS Med Chem Lett Volume: 16 Page(s): 532 - 533
04/10/2025 Authors: Hu Q-L; Liang SH -
6-Aryl Isoindolin-1-ones: Novel mGluR2 Negative Allosteric Modulators.
ACS Med Chem Lett Volume: 16 Page(s): 512 - 513
04/10/2025 Authors: Li Y; Liang SH -
Novel Triazole-Substituted Imidazo[1,2-a]Pyrimidine Compounds as cGAS inhibitors.
ACS Med Chem Lett Volume: 16 Page(s): 530 - 531
04/10/2025 Authors: Zhao T; Liang SH -
Novel Pyrazolo[1,5-a]pyrimidine-3,5-diamines as nSMase2 Inhibitors.
ACS Med Chem Lett Volume: 16 Page(s): 534 - 535
04/10/2025 Authors: Rong J; Liang SH -
Preparation of Substituted Heterocycles and Their Use as DNA Polymerase Theta (POLQ) Inhibitors.
ACS Med Chem Lett Volume: 16 Page(s): 536 - 537
04/10/2025 Authors: Zhou X; Liang SH -
Development of CD73 Inhibitors in Tumor Immunotherapy and Opportunities in Imaging and Combination Therapy.
J Med Chem Volume: 68 Page(s): 6860 - 6869
04/10/2025 Authors: Bi C; Patel JS; Liang SH -
Novel 6-Aryl isoindolin-1-one Derivatives as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 2.
ACS Med Chem Lett Volume: 16 Page(s): 510 - 511
04/10/2025 Authors: Li Y; Liang SH -
Enhancing the Stability of 211At Radiopharmaceuticals: Insights from Ortho-Substituent Strategies.
ACS Med Chem Lett Volume: 16 Page(s): 504 - 507
04/10/2025 Authors: Zhao T; Liang SH -
Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.
Nat Commun Volume: 16 Page(s): 2803
03/21/2025 Authors: Bhere D; Choi SH; van de Donk P; Hope D; Gortzak K; Kunnummal A; Khalsa J; Lechtich ER; Reinshagen C; Leon V -
Development of a Novel 18F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography.
ACS Pharmacol Transl Sci Volume: 8 Page(s): 800 - 807
03/14/2025 Authors: Rong J; Zhao C; Chaudhary AF; Chen J; Zhou X; Zhang K; Song Z; Sun Z; Gao Y; Zhang Z -
Identification of Phosphodiesterase-7 Inhibitors with Spiro[[1,3]oxazolo[5,4-f]quinazoline-9,1'-cyclohexan]-7-one Scaffold for the Treatment of Chronic Fatigue.
ACS Med Chem Lett Volume: 16 Page(s): 356 - 357
03/13/2025 Authors: Song Z; Liang SH -
Identification of Indazole- and Azaindazole-Substituted Cyclopentapyrroles as G2019S Leucine-Rich Repeat Kinase 2 Inhibitors for the Treatment of CNS Disorders.
ACS Med Chem Lett Volume: 16 Page(s): 368 - 370
03/13/2025 Authors: Feng S; Liang SH -
Novel Piperazine Derivatives as Selective Antagonists of GluN2B-Containing NMDARs under Acidic pH Conditions.
ACS Med Chem Lett Volume: 16 Page(s): 354 - 355
03/13/2025 Authors: Li Y; Liang SH -
Novel Cyclic Peptides Inhibiting Tumor Necrosis Factor Receptor 1 Activity.
ACS Med Chem Lett Volume: 16 Page(s): 363 - 365
03/13/2025 Authors: Hu Q-L; Liang SH -
Novel 5,6-Fused and 6,6-Fused Bicyclic Compounds as 15-Prostaglandin Dehydrogenase Modulators.
ACS Med Chem Lett Volume: 16 Page(s): 366 - 367
03/13/2025 Authors: Rong J; Liang SH -
Novel Pyrimidinyl Sulfonamide Derivatives as GPR17 Modulators.
ACS Med Chem Lett Volume: 16 Page(s): 361 - 362
03/13/2025 Authors: Zhao T; Liang SH -
Hydroquinazoline Derivatives as Novel Natriuretic Peptide Receptor 1 (NPR1) Activators.
ACS Med Chem Lett Volume: 16 Page(s): 358 - 360
03/13/2025 Authors: Zhou X; Liang SH -
Radiosynthesis and evaluation of novel 18F labeled PET ligands for imaging monoacylglycerol lipase.
Eur J Med Chem Volume: 285 Page(s): 117246
03/05/2025 Authors: Li Y; Mori W; Chaudhary A; Zhao C; Yamasaki T; Zhang Z; Feng S; Ware T; Rong J; Fujinaga M -
Development of a Novel 18F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography.
Mol Pharm Volume: 22 Page(s): 1657 - 1666
03/03/2025 Authors: Rong J; Zhao C; Chaudhary AF; Jones E; Van R; Song Z; Li Y; Chen J; Zhou X; Patel JS -
Novel Heterocyclic Piperazine Amide Derivatives as Alpha-synuclein PET Ligands for Diagnosis of Parkinson's Disease.
ACS Med Chem Lett Volume: 16 Page(s): 184 - 185
02/13/2025 Authors: Li Y; Liang SH -
Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents.
ACS Med Chem Lett Volume: 16 Page(s): 180 - 181
02/13/2025 Authors: Hu Q-L; Liang SH -
Imaging Alpha-synuclein with Novel 5H-Imidazo[1,5-b][1,2,4]triazole Radioligands for the Diagnosis of Parkinson's Disease.
ACS Med Chem Lett Volume: 16 Page(s): 182 - 183
02/13/2025 Authors: Song Z; Liang SH -
Novel Tricyclic KRAS Inhibitors for the Treatment of Cancer.
ACS Med Chem Lett Volume: 16 Page(s): 178 - 179
02/13/2025 Authors: Zhao T; Liang SH -
Discovery of 18F Labeled AZD5213 Derivatives as Novel Positron Emission Tomography (PET) Radioligands Targeting Histamine Subtype-3 Receptor.
Chembiochem Volume: 26 Page(s): e202400655
02/03/2025 Authors: Song Z; Li Y; Dahl K; Chaudhary A; Sun Z; Zhou X; Chen J; Gao Y; Rong J; Zhao C -
Synthesis, preclinical assessment, and first-in-human study of [18F]d4-FET for brain tumor imaging.
Eur J Nucl Med Mol Imaging Volume: 52 Page(s): 864 - 875
02/01/2025 Authors: Hou L; Chen Z; Chen F; Sheng L; Ye W; Dai Y; Guo X; Dong C; Li G; Liao K -
Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18kDa (TSPO) in neuroinflammatory rodent models and non-human primates.
Acta Pharmacol Sin Volume: 46 Page(s): 393 - 403
02/01/2025 Authors: Liao K; Chen J-H; Ma J; Dong C-C; Bi C-Y; Gao Y-B; Jiang Y-F; Wang T; Wei H-Y; Hou L -
Preclinical Evaluation of [ 18 F]P4B-2412 as Phosphodiesterase 4B Radioligand for Positron Emission Tomography Imaging.
bioRxiv
01/16/2025 Authors: Song Z; Li Y; Feng S; Chen J; Zhou X; Zhang Z; Sun Z; Rong J; Zhao C; Chaudhary A -
Brain development during the lifespan of cynomolgus monkeys.
Neuroimage Volume: 305 Page(s): 120952
01/01/2025 Authors: Tan Z; Nie B; Wu H; Li B; Shang J; Zhang T; Xiao Z; Dong C; Zeng C; Wu B -
Discovery of a highly specific radiolabeled antibody targeting B-cell maturation antigen: Applications in PET imaging of multiple myeloma.
Eur J Nucl Med Mol Imaging Volume: 52 Page(s): 599 - 610
01/01/2025 Authors: Ma J; Zhang S; Yang N; Shang J; Gao X; Chen J; Wei H; Li Y; Zeng H; Xu H -
Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.
J Neurochem Volume: 168 Page(s): 3936 - 3949
12/01/2024 Authors: Song R; Zhang J; Perszyk RE; Camp CR; Tang W; Kannan V; Li J; Xu Y; Chen J; Li Y -
Development of a Candidate 11C-Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography.
ACS Omega Volume: 9 Page(s): 44154 - 44163
11/05/2024 Authors: Rong J; Yamasaki T; Chen J; Kumata K; Zhao C; Fujinaga M; Hu K; Mori W; Zhang Y; Xie L -
Imaging Pulmonary Fibrosis and Treatment Efficacy In Vivo with Autotaxin-Specific PET Ligand [18F]ATX-1905.
Mol Pharm Volume: 21 Page(s): 5171 - 5181
10/07/2024 Authors: Deng X; Liu J; Zhou J; Shi Y; Song S; Chen J; Li Y; Yu B; Liang SH; Zhu X -
Half-Curcumin-Based Chemiluminescence Probes and Their Applications in Detecting Quasi-Stable Oxidized Proteins.
Angew Chem Int Ed Engl Volume: 63 Page(s): e202409896
10/01/2024 Authors: Yang J; Zhu B; Zhang J; Liang SH; Shen S; Ran C -
Discovery and evaluation of a novel 18F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity.
Acta Pharm Sin B Volume: 14 Page(s): 4014 - 4027
09/01/2024 Authors: Hu J; Li Y; Dong C; Wei H; Liao K; Wei J; Zhao C; Chaudhary A; Chen J; Xu H -
Radiosynthesis and Evaluation of 11C-Labeled Isoindolone-Based Positive Allosteric Modulators for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor 2.
ACS Pharmacol Transl Sci Volume: 7 Page(s): 2414 - 2423
08/09/2024 Authors: Li Y; Dahl K; Johnstrm P; Varns K; Farde L; Halldin C; Medd A; Maier D; Powell ME; Chen J -
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development.
Brain Volume: 147 Page(s): 1622 - 1635
05/03/2024 Authors: Ahmed H; Wang Y; Griffiths WJ; Levey AI; Pikuleva I; Liang SH; Haider A -
Development of Pyridothiophene Compounds for PET Imaging of -Synuclein.
Chemistry Volume: 30 Page(s): e202303921
04/22/2024 Authors: Pees A; Tong J; Birudaraju S; Munot YS; Liang SH; Saturnino Guarino D; Mach RH; Mathis CA; Vasdev N -
Preclinical Evaluation of Azabenzimidazole-Based PET Radioligands for -8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging.
Chembiochem Volume: 25 Page(s): e202300813
03/15/2024 Authors: Chen J; Li Y; Yu Q; Patel JS; Zhou X; Zhang K; Rong J; Zhao C; Chaudhary AF; Zhang W -
Preclinical Evaluation of Novel Positron Emission Tomography (PET) Probes for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2).
J Med Chem Volume: 67 Page(s): 2559 - 2569
02/22/2024 Authors: Chen Z; Chen J; Mori W; Yi Y; Rong J; Li Y; Leon ERC; Shao T; Song Z; Yamasaki T -
Co-Catalyzed Hydrofluorination of Alkenes: Photocatalytic Method Development and Electroanalytical Mechanistic Investigation.
J Am Chem Soc Volume: 146 Page(s): 4380 - 4392
02/21/2024 Authors: Liu J; Rong J; Wood DP; Wang Y; Liang SH; Lin S -
Radiosynthesis and evaluation of a novel 18F-labeled tracer for PET imaging of glycogen synthase kinase 3.
Am J Nucl Med Mol Imaging Volume: 14 Page(s): 327 - 336
01/01/2024 Authors: Xiao Z; Li Y; Haider A; Pfister SK; Rong J; Chen J; Zhao C; Zhou X; Song Z; Gao Y -
Radiosynthesis and preclinical evaluation of a carbon-11 labeled PET ligand for imaging metabotropic glutamate receptor 7.
Am J Nucl Med Mol Imaging Volume: 14 Page(s): 306 - 315
01/01/2024 Authors: Li Y; Xiao Z; Mori W; Sun J; Yamasaki T; Rong J; Fujinaga M; Chen J; Kumata K; Zhao C -
Poly(ADP-ribose) polymerase (PARP)-targeted PET imaging in non-oncology application: a pilot study in preclinical models of nonalcoholic steatohepatitis.
Am J Nucl Med Mol Imaging Volume: 14 Page(s): 41 - 47
01/01/2024 Authors: Jeppesen TE; Shao T; Chen J; Patel JS; Zhou X; Kjaer A; Liang SH -
Radiodifluoromethylation of well-functionalized molecules.
Am J Nucl Med Mol Imaging Volume: 14 Page(s): 82 - 86
01/01/2024 Authors: Zhang W; Li Y; Liang SH -
Characterization of (R)- and (S)-[18F]OF-NB1 in Rodents as Positron Emission Tomography Probes for Imaging GluN2B Subunit-Containing N-Methyl-d-Aspartate Receptors.
ACS Chem Neurosci Volume: 14 Page(s): 4323 - 4334
12/20/2023 Authors: Ahmed H; Wallimann R; Gisler L; Elghazawy NH; Gruber S; Keller C; Liang SH; Sippl W; Haider A; Ametamey SM -
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors.
J Med Chem Volume: 66 Page(s): 16018 - 16031
12/14/2023 Authors: Korff M; Chaudhary A; Li Y; Zhou X; Zhao C; Rong J; Chen J; Xiao Z; Elghazawy NH; Sippl W -
Preliminary Exploration of Pseudo-CT-Based Attenuation Correction for Simultaneous PET/MRI Brain Imaging in Nonhuman Primates.
ACS Omega Volume: 8 Page(s): 45438 - 45446
12/05/2023 Authors: Yoo C-H; DuBois JM; Wang L; Tang Y; Hou L; Xu H; Chen J; Liang SH; Izquierdo-Garcia D; Wey H-Y -
Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor.
Biomed Pharmacother Volume: 168 Page(s): 115842
12/01/2023 Authors: Chen J; Ran W; Huang Y; Wei J; Rong J; Wei H; Li Y; Li G; Chen Z; Collier L -
A Photolabile Curcumin-Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Alzheimer's Disease Treatment.
Angew Chem Int Ed Engl Volume: 62 Page(s): e202312519
11/06/2023 Authors: Kuang S; Zhu B; Zhang J; Yang F; Wu B; Ding W; Yang L; Shen S; Liang SH; Mondal P -
Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Nonhuman Primates.
ACS Chem Neurosci Volume: 14 Page(s): 3752 - 3760
10/18/2023 Authors: Haider A; Wang L; Gobbi L; Li Y; Chaudhary A; Zhou X; Chen J; Zhao C; Rong J; Xiao Z -
Development of Novel 11C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging.
ACS Med Chem Lett Volume: 14 Page(s): 1419 - 1426
10/12/2023 Authors: Rong J; Yamasaki T; Li Y; Kumata K; Zhao C; Haider A; Chen J; Xiao Z; Fujinaga M; Hu K -
Spirocyclic Iodonium Ylides for Fluorine-18 Radiolabeling of Non-Activated Arenes: From Concept to Clinical Research.
Chem Rec Volume: 23 Page(s): e202300072
09/01/2023 Authors: Chass M; Pees A; Lindberg A; Liang SH; Vasdev N -
Imaging Cholinergic Receptors in the Brain by Positron Emission Tomography.
J Med Chem Volume: 66 Page(s): 10889 - 10916
08/24/2023 Authors: Zhang J-J; Fu H; Lin R; Zhou J; Haider A; Fang W; Elghazawy NH; Rong J; Chen J; Li Y -
Radiochemistry for positron emission tomography.
Nat Commun Volume: 14 Page(s): 3257
06/05/2023 Authors: Rong J; Haider A; Jeppesen TE; Josephson L; Liang SH -
Small-animal PET study for noninvasive quantification of transmembrane AMPA receptor regulatory protein -8 (TARP -8) in the brain.
J Cereb Blood Flow Metab Volume: 43 Page(s): 893 - 904
06/01/2023 Authors: Yamasaki T; Ishii H; Hiraishi A; Kumata K; Wakizaka H; Zhang Y; Kurihara Y; Ogawa M; Nengaki N; Chen J -
Precision of quantitative parameters of 18F-FDG PET/CT in a rabbit VX2 tumor model.
Quant Imaging Med Surg Volume: 13 Page(s): 3816 - 3826
06/01/2023 Authors: Guo B; Hu L; Cai Q; Cheng Y; Shang J; Tang Y; Ling X; Gong J; Liang SH; Wang L -
Evaluation of [18F]Favipiravir in Rodents and Nonhuman Primates (NHP) with Positron Emission Tomography.
Pharmaceuticals (Basel) Volume: 16
03/31/2023 Authors: Rong J; Zhao C; Xia X; Li G; Haider A; Wei H; Chen J; Xiao Z; Li Y; Zhou X -
Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F]LW223 as a TSPO-targeted PET radioligand.
Pharmacol Res Volume: 189 Page(s): 106681
03/01/2023 Authors: Tan Z; Haider A; Zhang S; Chen J; Wei J; Liao K; Li G; Wei H; Dong C; Ran W -
Aryl Radical Enabled, Copper-Catalyzed Sonogashira-Type Cross-Coupling of Alkynes with Alkyl Iodides.
ACS Catal Volume: 13 Page(s): 2761 - 2770
02/17/2023 Authors: Zeng X; Wang C; Yan W; Rong J; Song Y; Xiao Z; Cai A; Liang SH; Liu W -
Aryl Radical Enabled, Copper-Catalyzed Sonogashira-Type Cross- Coupling of Alkynes with Alkyl Iodides
ACS CATALYSIS Volume: 13 Page(s): 2761 - 2770
02/17/2023 Authors: Zeng X; Wang C; Yan W; Rong J; Song Y; Xiao Z; Cai A; Liang SH; Liu W -
Translational molecular imaging and drug development in Parkinson's disease.
Mol Neurodegener Volume: 18 Page(s): 11
02/10/2023 Authors: Haider A; Elghazawy NH; Dawoud A; Gebhard C; Wichmann T; Sippl W; Hoener M; Arenas E; Liang SH -
Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand.
J Med Chem Volume: 66 Page(s): 1712 - 1724
02/09/2023 Authors: Chen Z; Chen J; Chen L; Yoo C-H; Rong J; Fu H; Shao T; Coffman K; Steyn SJ; Davenport AT -
Rest/stress myocardial perfusion imaging by positron emission tomography with 18F-Flurpiridaz: A feasibility study in mice.
J Nucl Cardiol Volume: 30 Page(s): 62 - 73
02/01/2023 Authors: Bengs S; Warnock GI; Portmann A; Mikail N; Rossi A; Ahmed H; Etter D; Treyer V; Gisler L; Pfister SK -
Evaluation of [18F]PF-06455943 as a Potential LRRK2 PET Imaging Agent in the Brain of Nonhuman Primates.
ACS Chem Neurosci Volume: 14 Page(s): 370 - 377
02/01/2023 Authors: Yoo C-H; Chen Z; Rani N; Chen J; Rong J; Chen L; Zhang L; Liang SH; Wey H-Y -
Evaluation of [F-18]PF-06455943 as a Potential LRRK2 PET Imaging Agent in the Brain of Nonhuman Primates
JOURNAL OF FLUIDS AND STRUCTURES Volume: 117 Page(s): 370 - 377
02/01/2023 Authors: Yoo C-H; Chen Z; Rani N; Chen J; Rong J; Chen L; Zhang L; Liang SH; Wey H-Y -
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors.
Res Sq
01/27/2023 Authors: Korff M; Chaudhary A; Li Y; Zhou X; Zhao C; Rong J; Chen J; Xiao Z; Elghazawy NH; Sippl W -
Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4.
Acta Pharm Sin B Volume: 13 Page(s): 213 - 226
01/01/2023 Authors: Haider A; Deng X; Mastromihalis O; Pfister SK; Jeppesen TE; Xiao Z; Pham V; Sun S; Rong J; Zhao C -
A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network.
Acta Pharmacol Sin Volume: 43 Page(s): 3002 - 3010
11/01/2022 Authors: Cheng R; Fujinaga M; Yang J; Rong J; Haider A; Ogasawara D; Van RS; Shao T; Chen Z; Zhang X -
Assessment of cholesterol homeostasis in the living human brain.
Sci Transl Med Volume: 14 Page(s): eadc9967
10/05/2022 Authors: Haider A; Zhao C; Wang L; Xiao Z; Rong J; Xia X; Chen Z; Pfister SK; Mast N; Yutuc E -
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
J Med Chem Volume: 65 Page(s): 10755 - 10808
08/25/2022 Authors: Fu H; Rong J; Chen Z; Zhou J; Collier T; Liang SH -
Development and Validation of [3H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs.
Pharmaceuticals (Basel) Volume: 15
08/02/2022 Authors: Ahmed H; Gisler L; Elghazawy NH; Keller C; Sippl W; Liang SH; Haider A; Ametamey SM -
Synthesis and 18F Labeling of Alkenyl Sulfonyl Fluorides via an Unconventional Elimination Pathway.
Org Lett Volume: 24 Page(s): 4992 - 4997
07/15/2022 Authors: Zhang W; Deng X; Zhang F-X; Lin J-H; Xiao J-C; Liang SH -
Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography.
J Med Chem Volume: 65 Page(s): 9144 - 9158
07/14/2022 Authors: Yu Q; Kumata K; Rong J; Chen Z; Yamasaki T; Chen J; Xiao Z; Ishii H; Hiraishi A; Shao T -
Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.
Nat Commun Volume: 13 Page(s): 2810
05/19/2022 Authors: Bhere D; Choi SH; van de Donk P; Hope D; Gortzak K; Kunnummal A; Khalsa J; Revai Lechtich E; Reinshagen C; Leon V -
Radiosynthesis of 6-(2-cyclobutyl-5-(methyl-11C)-3H-imidazo[4,5-b]pyridin-3-yl)benzo[d]thiazol-2(3H)-one and (2-cyclobutyl-3-(1H-indazol-5-yl)-5-[11C]methyl-3H-imidazo[4,5-b]pyridine for imaging gamma-8 dependent transmembrane AMPA receptor regulatory protein
Volume: 108 Page(s): S97 - S98
05/01/2022 Authors: Yu Q; Kumata K; Collier T; Tomita S; Zhang M-R; Liang S -
Synthesis and evaluation of novel PET ligands for imaging Orexin2 receptor (OX2R)
Volume: 108 Page(s): S101 - S101
05/01/2022 Authors: Rong J; Yamasaki T; Zhao C; Chen J; Xiao Z; Li Y; Collier T; Zhang M-R; Liang S -
Synthesis of a carbon-11 labeled metabotropic glutamate receptor 7 ligand for PET neuroimaging
Volume: 108 Page(s): S112 - S112
05/01/2022 Authors: Xiao Z; Zhao C; Haider A; Rong J; Zhang M-R; Liang S -
Molecular imaging of LPS induced neuroinflammation with P2x7 targeted [F-18]JNJ-64413739 by positron emission tomography
Volume: 108 Page(s): S92 - S93
05/01/2022 Authors: Chen J; Collier T; Liang S -
Structure-activity relationship of pyrazol-4-yl-pyridine derivatives for imaging the muscarinic acetylcholine receptor M-4
Volume: 108 Page(s): S25 - S25
05/01/2022 Authors: Haider A; Deng X; Pfister S; Jeppesen T; Xiao Z; Rong J; Connors T; Collier T; Mu L; Schibli R -
Molecular imaging of Poly (ADP-ribose) polymerase for nnalcoholic steatohepatitis detection in preclinical models
Volume: 108 Page(s): S67 - S68
05/01/2022 Authors: Jeppesen T; Shao T; Collier T; Liang S -
Synthesis of a carbon-11 labeled spiro-quinazolinone based PDE7 ligand for PET neuroimaging
Volume: 108 Page(s): S111 - S112
05/01/2022 Authors: Xiao Z; Sun J; Fujinaga M; Zhao C; Haider A; Rong J; Shao Y; Collier T; Lloyd KC; Wang L -
Radiosynthesis of [F-18]VU6010572 as a PET radiotracer for imaging metabotropic glutamate receptor 3 (mGluR3)
Volume: 108 Page(s): S100 - S101
05/01/2022 Authors: Rong J; Chen J; Zhao C; Zhiwei X; Collier T; Shao Y; Liang S -
Radiolabeling and preclinical evaluation of a novel PET ligand for imaging phosphodiesterase (PDE) 4B
Volume: 108 Page(s): S91 - S92
05/01/2022 Authors: Chen J; Collier T; Liang S -
Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination.
Acta Pharm Sin B Volume: 12 Page(s): 1963 - 1975
04/01/2022 Authors: Xiao Z; Wei H; Xu Y; Haider A; Wei J; Yuan S; Rong J; Zhao C; Li G; Zhang W -
Preliminary evaluation of [11C]MAGL-0519 as a promising PET ligand for the diagnosis of Hepatocellular carcinoma.
Bioorg Chem Volume: 120 Page(s): 105620
03/01/2022 Authors: Shao T; Chen Z; Cheng R; Collier L; Josephson L; Chung RT; Liang SH -
[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models.
Acta Pharm Sin B Volume: 12 Page(s): 308 - 315
01/01/2022 Authors: Shao T; Chen Z; Rong J; Belov V; Chen J; Jeyarajan A; Deng X; Fu H; Yu Q; Rwema SH -
The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO.
J Med Chem Volume: 64 Page(s): 17656 - 17689
12/23/2021 Authors: Chen Z; Haider A; Chen J; Xiao Z; Gobbi L; Honer M; Grether U; Arnold SE; Josephson L; Liang SH -
A Swine Hind Limb Ischemia Model Useful for Testing Peripheral Artery Disease Therapeutics.
J Cardiovasc Transl Res Volume: 14 Page(s): 1186 - 1197
12/01/2021 Authors: Deppen JN; Ginn SC; Kim NH; Wang L; Voll RJ; Liang SH; Goodman MM; Oshinski JN; Levit RD -
Development of a triazolobenzodiazepine-based PET probe for subtype-selective vasopressin 1A receptor imaging.
Pharmacol Res Volume: 173 Page(s): 105886
11/01/2021 Authors: Haider A; Xiao Z; Xia X; Chen J; Van RS; Kuang S; Zhao C; Rong J; Shao T; Ramesh P -
Imaging Autotaxin In Vivo with 18F-Labeled Positron Emission Tomography Ligands.
J Med Chem Volume: 64 Page(s): 15053 - 15068
10/28/2021 Authors: Deng X; Salgado-Polo F; Shao T; Xiao Z; Van R; Chen J; Rong J; Haider A; Shao Y; Josephson L -
Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold.
J Med Chem Volume: 64 Page(s): 14283 - 14298
10/14/2021 Authors: Rong J; Mori W; Xia X; Schafroth MA; Zhao C; Van RS; Yamasaki T; Chen J; Xiao Z; Haider A -
Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery.
J Med Chem Volume: 64 Page(s): 7083 - 7109
06/10/2021 Authors: Sun J; Xiao Z; Haider A; Gebhard C; Xu H; Luo H-B; Zhang H-T; Josephson L; Wang L; Liang SH -
Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping.
Acta Pharm Sin B Volume: 11 Page(s): 1686 - 1695
06/01/2021 Authors: Chen Z; Mori W; Rong J; Schafroth MA; Shao T; Van RS; Ogasawara D; Yamasaki T; Hiraishi A; Hatori A -
Radiosynthesis and PET Evaluation of a novel F-18-labeled modulator for muscarinic acetylcholine receptor subtype 4
Volume: 62
05/01/2021 Authors: Deng X; Rong J; Shao T; Zhang M-R; Sun S; Liang S -
Molecular imaging of alcoholic liver disease with phosphodiesterase (PDE) 4B targeted [F-18]PF-06445974 and positron emission tomography
Volume: 96-97 Page(s): S18 - S18
05/01/2021 Authors: Shao T; Chen J; Liang S -
Molecular imaging of cerebral dysfunction following liver failure with cannabinoid receptor type I targeted [F-18]MK-9470 and positron emission tomography
Volume: 96-97 Page(s): S53 - S54
05/01/2021 Authors: Shao T; Yu Q; Liang S -
Comparison of [C-11]FAAH-1906 and [C-11]MK3168 for PET Imaging of FAAH in the Brain of Non-human Primate
Volume: 62
05/01/2021 Authors: Wei H; Hou L; Chen Z; Ye W; Gan J; Li G; Wei J; Zhu H; Xu H; Liang S -
Translational PET imaging evaluation of [F-18]Favipiravir by positron emission tomography
Volume: 96-97 Page(s): S54 - S54
05/01/2021 Authors: Rong J; Xia X; Chen J; Shao T; Xiao Z; Zhao C; Pang F; Wang L; Liang S -
Development of a novel tight-binding reversible PET ligand for imaging monoacylglycerol lipase
Volume: 62
05/01/2021 Authors: Rong J; Xia X; Zhang M-R; Wang L; Liang S -
Subtype-selective vasopressin 1A receptor imaging by positron emission tomography
Volume: 96-97 Page(s): S58 - S58
05/01/2021 Authors: Haider A; Liang S; Xiao Z; Xia X; Kuang S; Van R; Chen J; Zhao C; Rong J -
A novel PET ligand for imaging monoacylglycerol lipase in naive and mouse models of Alzheimer's disease
Volume: 96-97 Page(s): S21 - S21
05/01/2021 Authors: Rong J; Chen J; Xia X; Zhao C; Shao T; Xiao Z; Pang F; Liang S -
Molecular imaging of murine liver fibrosis with sphingosine-1phosphate receptor 1 targeted PET ligand
Volume: 96-97 Page(s): S55 - S56
05/01/2021 Authors: Shao T; Chen J; Tu Z; Liang S -
[18F]-Alfatide PET Imaging of Nonalcoholic steatohepatitis (NASH) Through Noninvasive Measurement of Integrin alpha v beta 3 in Preclinical Models
Volume: 62
05/01/2021 Authors: Shao T; Lang L; Liang S -
Development of a novel F-18-labeled PET ligand for imaging phosphodiesterase (PDE) 4B
Volume: 62
05/01/2021 Authors: Chen J; Shao T; Sun S; Liang S -
Synthesis and Preliminary Evaluation of a Carbon-11 Labeled Probe for Imaging the Trace Amine-Associated Receptor 1 (TAAR1)
Volume: 62
05/01/2021 Authors: Haider A; Sun J; Chen J; Kumata K; Rong J; Shao T; Wang L; Xu H; Zhang M-R; Liang S -
Evaluation of CB2 PET Radioligand F-18 RoSMA18-d(6) in Non-Human Primates and Experimental Autoimmune Encephalomyelitis
Volume: 62
05/01/2021 Authors: Haider A; Gobbib L; Ronga J; Chen J; Shao T; Raposo C; Honer MH; Ahmed H; Grether UG; Liang S -
Spirocyclic Iodonium Ylide (SCIDY)-mediated radiofluorination of a novel PDE10A PET Ligand for neuroimaging
Volume: 62
05/01/2021 Authors: Xiao Z; Xu Y; Che C; Wei J; Haider A; Li G; Yuan S; Wei H; Liang S; Wang L -
Molecular imaging of Nonalcoholic steatohepatitis (NASH) with Autotaxin-targeted [18F]ATX-1905 and Positron Emission Tomography
Volume: 62
05/01/2021 Authors: Shao T; Deng X; Liang S -
Development of a novel PET tracer for imaging of gamma-8 dependent transmembrane AMPA receptor regulatory protein
Volume: 96-97 Page(s): S66 - S68
05/01/2021 Authors: Yu Q; Zhang M-R; Liang S -
Synthesis, radiolabeling and biological evaluation of a novel trace amine-associated receptor 1 (TAAR1) PET radioligand
Volume: 96-97 Page(s): S37 - S38
05/01/2021 Authors: Haider A; Sun J; Chen J; Rong J; Shao T; Wang L; Xu H; Zhang M-R; Liang S -
In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R.
ACS Chem Neurosci Volume: 12 Page(s): 998 - 1006
03/17/2021 Authors: Knight AC; Varlow C; Zi T; Liang SH; Josephson L; Schmidt K; Patel S; Vasdev N -
Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators.
Acta Pharmacol Sin Volume: 42 Page(s): 491 - 498
03/01/2021 Authors: Sun J-Y; Kumata K; Chen Z; Zhang Y-D; Chen J-H; Hatori A; Fu H-L; Rong J; Deng X-Y; Yamasaki T -
Recent developments on PET radiotracers for TSPO and their applications in neuroimaging.
Acta Pharm Sin B Volume: 11 Page(s): 373 - 393
02/01/2021 Authors: Zhang L; Hu K; Shao T; Hou L; Zhang S; Ye W; Josephson L; Meyer JH; Zhang M-R; Vasdev N -
Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development.
J Med Chem Volume: 64 Page(s): 123 - 149
01/14/2021 Authors: Hou L; Rong J; Haider A; Ogasawara D; Varlow C; Schafroth MA; Mu L; Gan J; Xu H; Fowler CJ -
Synthesis and preliminary evaluation of a novel positron emission tomography (PET) ligand for imaging fatty acid amide hydrolase (FAAH).
Bioorg Med Chem Lett Volume: 30 Page(s): 127513
11/01/2020 Authors: Chen Z; Hou L; Gan J; Cai Q; Ye W; Chen J; Tan Z; Zheng C; Li G; Xu H -
Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).
J Med Chem Volume: 63 Page(s): 11469 - 11483
10/22/2020 Authors: Yamasaki T; Zhang X; Kumata K; Zhang Y; Deng X; Fujinaga M; Chen Z; Mori W; Hu K; Wakizaka H -
Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography
Fluorination Page(s): 1 - 14
09/08/2020 Authors: Rong J; Liang H -
Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.
Bioorg Med Chem Lett Volume: 30 Page(s): 127326
08/15/2020 Authors: Deng X; Zhang Y; Chen Z; Kumata K; Van R; Rong J; Shao T; Hatori A; Mori W; Yu Q -
[18F]-Alfatide PET imaging of integrin v3 for the non-invasive quantification of liver fibrosis.
J Hepatol Volume: 73 Page(s): 161 - 169
07/01/2020 Authors: Shao T; Chen Z; Belov V; Wang X; Rwema SH; Kumar V; Fu H; Deng X; Rong J; Yu Q -
Classics in Neuroimaging: Imaging the Endocannabinoid Pathway with PET.
ACS Chem Neurosci Volume: 11 Page(s): 1855 - 1862
07/01/2020 Authors: Varlow C; Boileau I; Wey H-Y; Liang SH; Vasdev N -
Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy.
Nat Commun Volume: 11 Page(s): 2778
06/08/2020 Authors: Hu K; Xie L; Zhang Y; Hanyu M; Yang Z; Nagatsu K; Suzuki H; Ouyang J; Ji X; Wei J -
Fifty Years of Radiopharmaceuticals.
J Nucl Med Technol Volume: 48 Page(s): 34S - 39S
06/01/2020 Authors: Brugarolas P; Comstock J; Dick DW; Ellmer T; Engle JW; Lapi SE; Liang SH; Parent EE; Kishore Pillarsetty NV; Selivanova S -
Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' [11C]CO2 fixation method.
Bioorg Med Chem Lett Volume: 30 Page(s): 127068
05/01/2020 Authors: Chen Z; Chen J; Mast N; Rong J; Deng X; Shao T; Fu H; Yu Q; Sun J; Shao Y -
Molecular imaging of murine hepatic encephalopathy with cannabinoid receptor type I targeted [F-18]MK-9470 by positron emission tomography
Volume: 61
05/01/2020 Authors: Shao T; Yu Q; Liang S -
Preclinical evaluation of radiolabeled negative allosteric modulators for PET imaging of metabotropic glutamate receptor 2
Volume: 61
05/01/2020 Authors: Wang L; Zhang X; Chen Z; Xu H; Shao Y; Sheffler D; Zhang M-R; Liang S -
Synthesis and preclinical evaluation of C-11-labeled (6-aryl-1H-pyrrolo[3,2-b]pyridin-1-yl)acetamide for imaging GluN2B subunit of NMDA receptors
Volume: 61
05/01/2020 Authors: Sun J; Chen Z; Chen J; Fu H; Shao T; Wang L; Xu H; Zhang M-R; Liang S -
Synthesis of a carbon-11 labeled ligand targeting trace amine associated receptor 1
Volume: 61
05/01/2020 Authors: Sun J; Chen J; Chen Z; Shao Y; Wang L; Xu H; Liang S -
In-loop [C-11]CO(2)fixation: Application to the synthesis of a C-11-labeled cholesterol 24-hydroxylase inhibitor
Volume: 61
05/01/2020 Authors: Chen Z; Chen J; Mast N; Rong J; Shao Y; Wey H-Y; Josephson L; Pikuleva I; Liang S -
Development and preliminary evaluation of an aryl F-18-labeled PET tracer for imaging PDE10A
Volume: 61
05/01/2020 Authors: Cai Q; Hou L; Xiao Z; Che C; Li G; Zhang L; Xu H; Liang S; Wang L -
Synthesis of a C-11-labeled D-amino acid oxidase inhibitor for PET imaging
Volume: 61
05/01/2020 Authors: Deng X; Shao T; Shao Y; Josephson L; Wey H-Y; Zhang M-R; Liang S -
Synthesis of a F-18-Labeled autotaxin inhibitor for PET imaging
Volume: 61
05/01/2020 Authors: Deng X; Salgado-Polo F; Shao T; Shao Y; Josephson L; Perrakis A; Liang S -
Radiosynthesis of 6-(C-11-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one as a novel PET tracer towards imaging of gamma-8 dependent transmembrane AMPA receptor regulatory protein
Volume: 61
05/01/2020 Authors: Yu Q; Chen Z; Shao T; Shao Y; Zhang M-R; Liang S -
Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds.
Chem Commun (Camb) Volume: 56 Page(s): 4164 - 4167
04/14/2020 Authors: Xiao Z; Wang L; Wei J; Ran C; Liang SH; Shang J; Chen G-Y; Zheng C -
Discovery and Optimization of -Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia.
J Med Chem Volume: 63 Page(s): 3370 - 3380
03/26/2020 Authors: Liang J; Huang Y-Y; Zhou Q; Gao Y; Li Z; Wu D; Yu S; Guo L; Chen Z; Huang L -
Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors.
Tetrahedron Lett Volume: 61
03/19/2020 Authors: Chen J; Gan J; Sun J; Chen Z; Fu H; Rong J; Deng X; Shang J; Gong J; Shao T -
A concisely automated synthesis of TSPO radiotracer [18 F]FDPA based on spirocyclic iodonium ylide method and validation for human use.
J Labelled Comp Radiopharm Volume: 63 Page(s): 119 - 128
03/01/2020 Authors: Wang L; Yao S; Tang R; Zhu H; Zhang L; Gong J; Chen Q; Collier TL; Xu H; Liang SH -
Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's Disease.
Molecules Volume: 25
02/22/2020 Authors: Varlow C; Murrell E; Holland JP; Kassenbrock A; Shannon W; Liang SH; Vasdev N; Stephenson NA -
Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging -8 dependent transmembrane AMPA receptor regulatory protein by PET.
Bioorg Med Chem Lett Volume: 30 Page(s): 126879
02/15/2020 Authors: Yu Q; Kumata K; Li H; Zhang Y; Chen Z; Zhang X; Shao T; Hatori A; Yamasaki T; Xie L -
Salen-based bifunctional chemosensor for copper (II) ions: Inhibition of copper-induced amyloid- aggregation.
Anal Chim Acta Volume: 1097 Page(s): 144 - 152
02/08/2020 Authors: Yu H-J; Zhao W; Zhou Y; Cheng G-J; Sun M; Wang L; Yu L; Liang SH; Ran C -
Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2.
Theranostics Volume: 10 Page(s): 11178 - 11196
01/01/2020 Authors: Zhang X; Zhang Y; Chen Z; Shao T; Van R; Kumata K; Deng X; Fu H; Yamasaki T; Rong J -
Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment.
Front Oncol Volume: 10 Page(s): 317
01/01/2020 Authors: Lin X; Xiao Z; Chen T; Liang SH; Guo H -
A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model.
Neuroimage Volume: 203 Page(s): 116163
12/01/2019 Authors: Nie B; Wang L; Hu Y; Liang S; Tan Z; Chai P; Tang Y; Shang J; Pan Z; Zhao X -
Structural Basis for Achieving GSK-3 Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
J Med Chem Volume: 62 Page(s): 9600 - 9617
11/14/2019 Authors: Bernard-Gauthier V; Mossine AV; Knight A; Patnaik D; Zhao W-N; Cheng C; Krishnan HS; Xuan LL; Chindavong PS; Reis SA -
Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes.
J Med Chem Volume: 62 Page(s): 8866 - 8872
10/10/2019 Authors: Chen Z; Mori W; Fu H; Schafroth MA; Hatori A; Shao T; Zhang G; Van RS; Zhang Y; Hu K -
MOLECULAR IMAGING OF MURINE HEPATIC ENCEPHALOPATHY WITH CANNABINOID RECEPTOR TYPE ITARGETED [F-18]MK-9470 AND POSITRON EMISSION TOMOGRAPHY
Volume: 70 Page(s): 1239A - 1239A
10/01/2019 Authors: Shao T; Yu Q; Bloom PP; Lin W; Liang S; Chung RT -
[F-18]-ALFATIDE PET IMAGING OF LIVER FIBROGENESIS THROUGH NONINVASIVE MEASUREMENT OF INTEGRIN alpha v beta 3 IN PRECLINICAL MODELS
Volume: 70 Page(s): 1238A - 1239A
10/01/2019 Authors: Shao T; Chen Z; Rwema SH; Lin W; Liang S; Chung RT -
ASSESSMENT OF A MONOACYLGLYCEROL LIPASE-TARGETED PET PROBE FOR LIVER FIBROSIS DETECTION AND STAGING IN PRECLINICAL MODELS
Volume: 70 Page(s): 1238A - 1238A
10/01/2019 Authors: Shao T; Schaefer E; Chen Z; Lin W; Liang S; Chung RT -
Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase2 (LRRK2) in Parkinson's Disease.
ChemMedChem Volume: 14 Page(s): 1580 - 1585
09/04/2019 Authors: Chen Z; Shao T; Gao W; Fu H; Collier TL; Rong J; Deng X; Yu Q; Zhang X; Davenport AT -
[18 F]Ethenesulfonyl Fluoride as a Practical Radiofluoride Relay Reagent.
Chemistry Volume: 25 Page(s): 7613 - 7617
06/07/2019 Authors: Zhang B; Fraser BH; Klenner MA; Chen Z; Liang SH; Massi M; Robinson AJ; Pascali G -
Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.
ACS Chem Neurosci Volume: 10 Page(s): 2263 - 2275
05/15/2019 Authors: Fu H; Tang W; Chen Z; Belov VV; Zhang G; Shao T; Zhang X; Yu Q; Rong J; Deng X -
Development of a novel PET ligand for imaging leucine rich repeat kinase 2
Volume: 62 Page(s): S232 - S233
05/01/2019 Authors: Chen Z; Shao T; Fu H; Wang L; Collier T; Wey H-Y; Shao Y; Josephson L; Liang S -
Facile 18F labeling of non-activated arenes via a spirocyclic iodonium(III) ylide method and its application in the synthesis of the mGluR5 PET radiopharmaceutical [18F]FPEB.
Nat Protoc Volume: 14 Page(s): 1530 - 1545
05/01/2019 Authors: Liang SH; Wang L; Stephenson NA; Rotstein BH; Vasdev N -
A novel [F-18]fluoride relay reagent for radiofluorination reactions
Volume: 62 Page(s): S172 - S173
05/01/2019 Authors: Zhang B; Fraser B; Klenner M; Chen Z; Liang S; Massi M; Robinson A; Pascali G -
Novel C-11-labeled and F-18-labeled allosteric modulators for M-4 imaging
Volume: 62 Page(s): S246 - S248
05/01/2019 Authors: Deng X; Chen Z; Zhang X; Shao T; Sun S; Shao Y; Josephson L; Liang S -
Efficient radio thesis and preliminary autoradiography evaluation of a potent "C -labeled L 2 inhibitor
Volume: 60
05/01/2019 Authors: Chen Z; Shao T; Fu H; Wang L; Shao Y; Wey H-Y; Collier L; Josephson L; Liang S -
Radiosynthesis and Preclinical Evaluation of [C-11]PF-06447475 for LRRK2 imaging
Volume: 60
05/01/2019 Authors: Chen Z; Wang L; Ishii H; Yamasaki T; Shao T; Shao Y; Josephson L; Zhang M-R; Liang S -
Design, sy thesis and evaluation of reversible and irreversible monoacylglycerol lipase PET tracers using a 'tail-tching' strategy on a piperazinyl azetidine skeleton
Volume: 60
05/01/2019 Authors: Chen Z; Mori W; Deng X; Cheng R; Fu H; Shao Y; Josephson L; Zhang M-R; Liang S -
Spirocyclic iodonium ylide (SCIDY)-mediated automatic radiolabeling of [F-18]FDPA and validation for human use
Volume: 62 Page(s): S323 - S324
05/01/2019 Authors: Wang L; Yao S; Zhu H; Tang R; Xu H; Liang S -
Radiosynthesis and preclinical evaluation of a novel F-18-labeled MAGL inhibitor PF-06795071 for MAGL imaging
Volume: 60
05/01/2019 Authors: Chen Z; Fu H; Wang L; Shao Y; Josephson L; Liang S -
Preclinical evaluation of [C-11]AZ13713945 and its analogs as muscarinic acetylcholine receptor M4 PET ligands
Volume: 62 Page(s): S235 - S236
05/01/2019 Authors: Deng X; Hatori A; Shao T; Kumata K; Chen Z; Shao Y; Sun S; Josephson L; Zhang M-R; Liang S -
Radiosynthesis of 6-(2-cyclobutyl-5-[11C]methyl-3H-imidazo[4,5-b]pyridin-3-yl)benzo[d]thiazol-2(3H)-one as a novel PET tracer for imaging of gamma-8 dependent transmembrane PA receptor regulatory protein
Volume: 60
05/01/2019 Authors: Yu Q; Chen Z; Kumata K; Shao T; Wey H-Y; Shao Y; Josephson L; Zhang M-R; Liang S -
Synthesis and preclinical evaluation of "C labeled (6-ary1-1H-pyrrolo[3,2-b]pyridin-1 yl)acetamide for imaging GluN2B subunit of rector NMDA
Volume: 60
05/01/2019 Authors: Sun J; Chen Z; Wang L; Liang S; Xu H -
Preclinica 18-ld rb eliil l iono a Flabepoeasa potent PET imaging ligand for GluN2B subunit in NMDA receptors
Volume: 60
05/01/2019 Authors: Fu H; Shao T; Chen Z; Shao Y; Sun S; Josephson L; Wey H-Y; Daunais J; Li Z; Liang S -
Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton.
J Med Chem Volume: 62 Page(s): 3336 - 3353
04/11/2019 Authors: Chen Z; Mori W; Deng X; Cheng R; Ogasawara D; Zhang G; Schafroth MA; Dahl K; Fu H; Hatori A -
PET imaging of EGFR expression using an 18F-labeled RNA aptamer.
Eur J Nucl Med Mol Imaging Volume: 46 Page(s): 948 - 956
04/01/2019 Authors: Cheng S; Jacobson O; Zhu G; Chen Z; Liang SH; Tian R; Yang Z; Niu G; Zhu X; Chen X -
Half-curcumin analogues as PET imaging probes for amyloid beta species.
Chem Commun (Camb) Volume: 55 Page(s): 3630 - 3633
03/21/2019 Authors: Yang J; Cheng R; Fu H; Yang J; Kumar M; Lu J; Xu Y; Liang SH; Cui M; Ran C -
Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions.
Angew Chem Int Ed Engl Volume: 58 Page(s): 2580 - 2605
02/25/2019 Authors: Deng X; Rong J; Wang L; Vasdev N; Zhang L; Josephson L; Liang SH -
Synthesis and Preliminary Evaluation of 11 C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype4.
ChemMedChem Volume: 14 Page(s): 303 - 309
02/05/2019 Authors: Deng X; Hatori A; Chen Z; Kumata K; Shao T; Zhang X; Yamasaki T; Hu K; Yu Q; Ma L -
Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors.
J Med Chem Volume: 62 Page(s): 403 - 419
01/24/2019 Authors: Fu H; Chen Z; Josephson L; Li Z; Liang SH -
PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease.
Mol Imaging Volume: 18 Page(s): 1536012119871455
01/01/2019 Authors: Shao T; Josephson L; Liang SH -
Correction to: PET imaging of EGFR expression using an 18F-labeled RNA aptamer.
Eur J Nucl Med Mol Imaging Volume: 45 Page(s): 2245
11/01/2018 Authors: Cheng S; Jacobson O; Zhu G; Chen Z; Liang SH; Tian R; Yang Z; Niu G; Zhu X; Chen X -
Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging 8-dependent transmembrane AMPA receptor regulatory protein.
Eur J Med Chem Volume: 157 Page(s): 898 - 908
09/05/2018 Authors: Chen Z; Mori W; Zhang X; Yamasaki T; Dunn PJ; Zhang G; Fu H; Shao T; Zhang Y; Hatori A -
Use of a single quadrupole mass spectrometer in radiochemistry
Volume: 256
08/19/2018 Authors: Collier T; Liang S; Vasdev N -
Novel radiofluorination technology to facilitate PET imaging studies and drug discovery
Volume: 256
08/19/2018 Authors: Liang S -
Spirocyclic iodonium ylide (SCIDY) mediated 18F-fluorination: A general method for the preparation of PET radiopharmaceuticals
Volume: 256
08/19/2018 Authors: Liang S -
Ru-Photoredox-Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids through N-(acyloxy)phthalimide.
Org Lett Volume: 20 Page(s): 4824 - 4827
08/17/2018 Authors: Zheng C; Wang Y; Xu Y; Chen Z; Chen G; Liang SH -
First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR127303.
Neuroimage Volume: 176 Page(s): 313 - 320
08/01/2018 Authors: Yamasaki T; Mori W; Zhang Y; Hatori A; Fujinaga M; Wakizaka H; Kurihara Y; Wang L; Nengaki N; Ohya T -
Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry.
J Fluor Chem Volume: 210 Page(s): 46 - 55
06/01/2018 Authors: Collier TL; Dahl K; Stephenson NA; Holland JP; Riley A; Liang SH; Vasdev N -
Preclinical evaluation of C-11-JNJ55511118 and C-11-JNJ56022486 for imaging subtype-selective AMPA receptor
Volume: 59
05/01/2018 Authors: Chen Z; Zhang X; Shao T; Vasdev N; Shao Y; Tomita S; Zhang M-R; Liang S -
Radiosynthesis and preclinical evaluation of < C-11 > PBT2 for probing the metal hypothesis of Alzheimer's disease
Volume: 59
05/01/2018 Authors: Krishnan H; Bernard-Gauthier V; Placzek M; Dahl K; Collier T; Ran C; Hooker J; Liang S; Vasdev N -
Synthesis and preclinical evaluation of C-11-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for development of TARP gamma-8 dependent AMPAR PET tracers
Volume: 59
05/01/2018 Authors: Chen Z; Zhang X; Shao T; Shao Y; Tomita S; Zhang M-R; Liang S -
Development of C-11-labeled mGluR(2) negative allosteric modulators for PET imaging
Volume: 59
05/01/2018 Authors: Zhang X; Chen Z; Kang HJ; Sheffler D; Cosford N; Vasdev N; Shao Y; Zhang M-R; Liang S -
Novel C-11-labeled positive allosteric modulators for imaging muscarinic acetylcholine receptor M-4
Volume: 59
05/01/2018 Authors: Deng X; Chen Z; Zhang X; Shao T; Shao Y; Liang S -
PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [11C]PBR28.
Mol Imaging Biol Volume: 20 Page(s): 188 - 193
04/01/2018 Authors: Ran C; Albrecht DS; Bredella MA; Yang J; Yang J; Liang SH; Cypess AM; Loggia ML; Atassi N; Moore A -
Recent Advances in 18F Radiochemistry: A Focus on B-18F, Si-18F, Al-18F, and C-18F Radiofluorination via Spirocyclic Iodonium Ylides.
J Nucl Med Volume: 59 Page(s): 568 - 572
04/01/2018 Authors: Bernard-Gauthier V; Lepage ML; Waengler B; Bailey JJ; Liang SH; Perrin DM; Vasdev N; Schirrmacher R -
In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies.
J Med Chem Volume: 61 Page(s): 2278 - 2291
03/22/2018 Authors: Cheng R; Mori W; Ma L; Alhouayek M; Hatori A; Zhang Y; Ogasawara D; Yuan G; Chen Z; Zhang X -
"In-loop" [11 C]CO2 fixation: Prototype and proof of concept.
J Labelled Comp Radiopharm Volume: 61 Page(s): 252 - 262
03/01/2018 Authors: Dahl K; Collier TL; Cheng R; Zhang X; Sadovski O; Liang SH; Vasdev N -
Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [11C]PBT2.
Mol Pharm Volume: 15 Page(s): 695 - 702
02/05/2018 Authors: Krishnan HS; Bernard-Gauthier V; Placzek MS; Dahl K; Narayanaswami V; Livni E; Chen Z; Yang J; Collier TL; Ran C -
The Binding of BF-227-Like Benzoxazoles to Human -Synuclein and Amyloid Peptide Fibrils.
Mol Imaging Volume: 17 Page(s): 1536012118796297
01/01/2018 Authors: Josephson L; Stratman N; Liu Y; Qian F; Liang SH; Vasdev N; Patel S -
18 F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.
Chemistry Volume: 23 Page(s): 15553 - 15577
11/07/2017 Authors: Krishnan HS; Ma L; Vasdev N; Liang SH -
Discovery of PET radiopharmaceuticals at the academia-industry interface.
Drug Discov Today Technol Volume: 25 Page(s): 19 - 26
11/01/2017 Authors: Bernard-Gauthier V; Collier TL; Liang SH; Vasdev N -
Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2.
ACS Chem Neurosci Volume: 8 Page(s): 1937 - 1948
09/20/2017 Authors: Zhang X; Kumata K; Yamasaki T; Cheng R; Hatori A; Ma L; Zhang Y; Xie L; Wang L; Kang HJ -
Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and 64CuCl2.
Sci Rep Volume: 7 Page(s): 8298
08/15/2017 Authors: Yang J; Yang J; Wang L; Moore A; Liang SH; Ran C -
A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation.
J Med Chem Volume: 60 Page(s): 5222 - 5227
06/22/2017 Authors: Wang L; Cheng R; Fujinaga M; Yang J; Zhang Y; Hatori A; Kumata K; Yang J; Vasdev N; Du Y -
[11C]Cyanation of arylboronic acids in aqueous solutions.
Chem Commun (Camb) Volume: 53 Page(s): 6597 - 6600
06/21/2017 Authors: Ma L; Placzek MS; Hooker JM; Vasdev N; Liang SH -
Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib.
Nat Commun Volume: 8 Page(s): 15761
06/08/2017 Authors: Collier TL; Normandin MD; Stephenson NA; Livni E; Liang SH; Wooten DW; Esfahani SA; Stabin MG; Mahmood U; Chen J -
Novel C-11-labeled negative allosteric modulators for mGluR(2) imaging
Volume: 58
05/01/2017 Authors: Zhang X; Wang L; Zhang M-R; Liang S -
Spirocyclic iodonium ylide-based synthesis of [18F] FDPA and preliminary PET studies in neuroinflammation
Volume: 58
05/01/2017 Authors: Wang L; Cheng R; Fujinaga M; Vasdev N; Zhang M-R; Liang S -
Nucleophilic Radiolabeling of Aryl-CF2H from [F-18] Fluoride Ion
Volume: 58
05/01/2017 Authors: Yuan G; Wang L; Vasdev N; Liang S -
Radiosynthesis of C-11-labeled quinoline carboxamide for imaging mGluR(2)
Volume: 60 Page(s): S243 - S243
05/01/2017 Authors: Zhang X; Wang L; Liang S -
Spirocyclic iodonium ylide-based radiolabeling of [F-18]F-DPA and preliminary PET imaging studies
Volume: 60 Page(s): S258 - S258
05/01/2017 Authors: Wang L; Cheng R; Fujinaga M; Vasdev N; Zhang M-R; Liang S -
Metal-free F-18-fluorination of Aryl-CF2H via Nucleophilic Radiofluorination and Oxidative C-H Activation
Volume: 60 Page(s): S322 - S322
05/01/2017 Authors: Yuan G; Wang F; Wang L; Vasdev N; Tang P; Liang S -
Radiosynthesis of [C-11] SL25.1188 via "in-Loop" [C-11] CO2 Fixation: Pre-clinical Evaluation for MAO-B Activity in Alzheimer's Disease
Volume: 58
05/01/2017 Authors: Dahl K; Collier T; Cheng R; Svedberg M; Toth M; Das A; Nag S; Liang S; Halldin C; Vasdev N -
An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18 F-Labeled -SCF3 Carbonyl Compounds.
Angew Chem Int Ed Engl Volume: 56 Page(s): 3196 - 3200
03/13/2017 Authors: Zheng J; Cheng R; Lin J-H; Yu D-H; Ma L; Jia L; Zhang L; Wang L; Xiao J-C; Liang SH -
Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3 Ligands for Positron Emission Tomography Imaging.
ACS Med Chem Lett Volume: 8 Page(s): 287 - 292
03/09/2017 Authors: Hu K; Patnaik D; Collier TL; Lee KN; Gao H; Swoyer MR; Rotstein BH; Krishnan HS; Liang SH; Wang J -
Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics.
Int J Med Chem Volume: 2017 Page(s): 4852537
01/01/2017 Authors: Yuan G; Jankins TC; Patrick CG; Philbrook P; Sears O; Hatfield S; Sitkovsky M; Vasdev N; Liang SH; Ondrechen MJ -
Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET.
Mol Imaging Volume: 16 Page(s): 1536012117736669
01/01/2017 Authors: Collier TL; Maresca KP; Normandin MD; Richardson P; McCarthy TJ; Liang SH; Waterhouse RN; Vasdev N -
Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors.
Beilstein J Org Chem Volume: 13 Page(s): 2922 - 2927
01/01/2017 Authors: Collier TL; Liang SH; Mann JJ; Vasdev N; Kumar JSD -
Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation.
Chem Commun (Camb) Volume: 53 Page(s): 126 - 129
12/20/2016 Authors: Yuan G; Wang F; Stephenson NA; Wang L; Rotstein BH; Vasdev N; Tang P; Liang SH -
Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification.
Sci Rep Volume: 6 Page(s): 35613
10/20/2016 Authors: Yang J; Yang J; Liang SH; Xu Y; Moore A; Ran C -
Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors.
Bioorg Med Chem Lett Volume: 26 Page(s): 4857 - 4860
10/01/2016 Authors: Yuan G; Jones GB; Vasdev N; Liang SH -
Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines.
Angew Chem Int Ed Engl Volume: 55 Page(s): 11882 - 11886
09/19/2016 Authors: Yuan Z; Cheng R; Chen P; Liu G; Liang SH -
Synthesis of (18) F-Difluoromethylarenes from Aryl (Pseudo) Halides.
Angew Chem Int Ed Engl Volume: 55 Page(s): 10786 - 10790
08/26/2016 Authors: Shi H; Braun A; Wang L; Liang SH; Vasdev N; Ritter T -
(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.
Chem Soc Rev Volume: 45 Page(s): 4708 - 4726
08/22/2016 Authors: Rotstein BH; Liang SH; Placzek MS; Hooker JM; Gee AD; Doll F; Wilson AA; Vasdev N -
Radiosynthesis of fluorine-18 labeled difluoromethylarenes
Volume: 252
08/20/2016 Authors: Liang S; Shi H; Ritter T; Vasdev N -
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Angew Chem Int Ed Engl Volume: 55 Page(s): 9601 - 9605
08/08/2016 Authors: Liang SH; Chen JM; Normandin MD; Chang JS; Chang GC; Taylor CK; Trapa P; Plummer MS; Para KS; Conn EL -
Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides.
Chem Sci Volume: 7 Page(s): 4407 - 4417
07/01/2016 Authors: Rotstein BH; Wang L; Liu RY; Patteson J; Kwan EE; Vasdev N; Liang SH -
Synthesis and preliminary pet imaging of C-11- and F-18-isotopologues of the ROS1/ALK inhibitor PF-06463922 in nonhuman primates
Volume: 57
05/01/2016 Authors: Collier T; Normandin M; Stephenson N; Livni E; Liang S; Richardson P; Maresca K; Waterhouse R; El Fakhri G; Vasdev N -
Microfluidic 2-step radiosynthesis of [F-18]FEMPT, a high affinity PET radiotracer for 5-HT1AR
Volume: 57
05/01/2016 Authors: Collier T; Liang S; Mann J; Vasdev N; Kumar D -
Practical Synthesis of F-18-Difluoromethylarenes from Aryl Halides
Volume: 57
05/01/2016 Authors: Liang S; Shi H; Tobias R; Vasdev N -
Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([C]MPPO) Based on -Ketoheterocyclic Scaffold.
ACS Chem Neurosci Volume: 7 Page(s): 109 - 118
01/20/2016 Authors: Wang L; Yui J; Wang Q; Zhang Y; Mori W; Shimoda Y; Fujinaga M; Kumata K; Yamasaki T; Hatori A -
Discovery of a novel fluorescent probe for the sensitive detection of -amyloid deposits.
Biosens Bioelectron Volume: 75 Page(s): 136 - 141
01/15/2016 Authors: Ren W; Xu M; Liang SH; Xiang H; Tang L; Zhang M; Ding D; Li X; Zhang H; Hu Y -
Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics.
Angew Chem Int Ed Engl Volume: 55 Page(s): 528 - 533
01/11/2016 Authors: Rashidian M; Wang L; Edens JG; Jacobsen JT; Hossain I; Wang Q; Victora GD; Vasdev N; Ploegh H; Liang SH -
Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors.
Curr Top Med Chem Volume: 16 Page(s): 1830 - 1842
01/01/2016 Authors: Kassenbrock A; Vasdev N; Liang SH -
Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry.
Curr Top Med Chem Volume: 16 Page(s): 1200 - 1216
01/01/2016 Authors: Feng M; Tang B; Liang SH; Jiang X -
Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase.
Theranostics Volume: 6 Page(s): 1145 - 1159
01/01/2016 Authors: Wang L; Mori W; Cheng R; Yui J; Hatori A; Ma L; Zhang Y; Rotstein BH; Fujinaga M; Shimoda Y -
Preclinical PET Neuroimaging of [11C]Bexarotene.
Mol Imaging Volume: 15
01/01/2016 Authors: Rotstein BH; Placzek MS; Krishnan HS; Pekoak A; Collier TL; Wang C; Liang SH; Burstein ES; Hooker JM; Vasdev N -
Difluorocarbene-Derived Trifluoromethylthiolation and [(18)F]Trifluoromethylthiolation of Aliphatic Electrophiles.
Angew Chem Int Ed Engl Volume: 54 Page(s): 13236 - 13240
11/02/2015 Authors: Zheng J; Wang L; Lin J-H; Xiao J-C; Liang SH -
18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression.
J Nucl Med Volume: 56 Page(s): 1780 - 1785
11/01/2015 Authors: Jacobson O; Weiss ID; Wang L; Wang Z; Yang X; Dewhurst A; Ma Y; Zhu G; Niu G; Kiesewetter DO -
Ortho-Stabilized (18) F-Azido Click Agents and their Application in PET Imaging with Single-Stranded DNA Aptamers.
Angew Chem Int Ed Engl Volume: 54 Page(s): 12777 - 12781
10/19/2015 Authors: Wang L; Jacobson O; Avdic D; Rotstein BH; Weiss ID; Collier L; Chen X; Vasdev N; Liang SH -
Synthesis of 18F-Arenes from Spirocyclic Iodonium(III) Ylides via Continuous-Flow Microfluidics.
J Fluor Chem Volume: 178 Page(s): 249 - 253
10/01/2015 Authors: Calderwood S; Collier TL; Gouverneur V; Liang SH; Vasdev N -
Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer's Disease.
ACS Med Chem Lett Volume: 6 Page(s): 1025 - 1029
09/10/2015 Authors: Liang SH; Southon AG; Fraser BH; Krause-Heuer AM; Zhang B; Shoup TM; Lewis R; Volitakis I; Han Y; Greguric I -
Total Radiosynthesis: Thinking outside "the box".
Aust J Chem Volume: 68 Page(s): 1319 - 1328
09/01/2015 Authors: Liang SH; Vasdev N -
General method for radiolabeling nonactivated arenes with [18F]fluoride and its transition to clinical use
Volume: 250
08/16/2015 Authors: Liang SH; Rotstein B; Stephenson N; Wang L; Vasdev N -
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist.
Molecules Volume: 20 Page(s): 9550 - 9559
05/26/2015 Authors: Rotstein BH; Liang SH; Belov VV; Livni E; Levine DB; Bonab AA; Papisov MI; Perlis RH; Vasdev N -
Radiosynthesis and evaluation of [C-11]isradipine, a calcium channel antagonist, for PET neuroimaging
Volume: 58 Page(s): S298 - S298
05/15/2015 Authors: Rotstein BH; Bonab AA; Livni E; Perlis RH; Liang SH; Vasdev N -
Iodonium Ylide Mediated Radiofluorination: Expanded Substrate Scope and Validation of a Radiopharmaceutical for Human Use
Volume: 58 Page(s): S190 - S190
05/15/2015 Authors: Liang SH; Rotstein BH; Stephenson N; Wang L; Patteson J; Collier L; Vasdev N -
Development of [18F]FEMPT, a high affinity PET tracer for 5-HT1AR
Volume: 56
05/01/2015 Authors: Kumar JSD; Arango V; Majo V; Simpson N; Underwood M; Kassir S; Liang S; Collier T; Vasdev N; Mann J -
PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates.
ACS Chem Neurosci Volume: 6 Page(s): 535 - 541
04/15/2015 Authors: Liang SH; Holland JP; Stephenson NA; Kassenbrock A; Rotstein BH; Daignault CP; Lewis R; Collier L; Hooker JM; Vasdev N -
Iodonium ylide-mediated radiofluorination of 18F-FPEB and validation for human use.
J Nucl Med Volume: 56 Page(s): 489 - 492
03/01/2015 Authors: Stephenson NA; Holland JP; Kassenbrock A; Yokell DL; Livni E; Liang SH; Vasdev N -
PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates.
Mol Pharm Volume: 11 Page(s): 3832 - 3838
11/03/2014 Authors: Rotstein BH; Wey H-Y; Shoup TM; Wilson AA; Liang SH; Hooker JM; Vasdev N -
C(sp)-F bond formation by transition-metal-based [F]fluorination.
Angew Chem Int Ed Engl Volume: 53 Page(s): 11416 - 11418
10/20/2014 Authors: Liang SH; Vasdev N -
Iodonium metathesis reactions.
Angew Chem Int Ed Engl Volume: 53 Page(s): 9637 - 9639
09/01/2014 Authors: Kasahara T; Jang YJ; Racicot L; Panagopoulos D; Liang SH; Ciufolini MA -
Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics.
Nat Commun Volume: 5 Page(s): 4365
07/09/2014 Authors: Rotstein BH; Stephenson NA; Vasdev N; Liang SH -
Synthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging.
ACS Med Chem Lett Volume: 5 Page(s): 668 - 672
06/12/2014 Authors: Rotstein BH; Hooker JM; Woo J; Collier TL; Brady TJ; Liang SH; Vasdev N -
First human use of the tau radiopharmaceutical [F-18]T807 by microfluidic flow chemistry
Volume: 55
05/01/2014 Authors: Collier T; Yokell D; Rice P; Jackson R; Shoup T; Normandin M; Brady T; El Fakhri G; Liang S; Vasdev N -
Purification of radiotracers produced by both microfluidic and conventional modules
Volume: 55
05/01/2014 Authors: Collier T; Akula M; Liang S -
Spiro hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics
Volume: 55
05/01/2014 Authors: Liang S; Rotstein B; Stephenson N; Vasdev N -
Synthesis of [C-11]bexarotene by [C-11]CO2 fixation: Preliminary preclinical imaging in nonhuman primate
Volume: 55
05/01/2014 Authors: Rotstein B; Liang S; Collier T; Woo J; Brady T; Hooker J; Vasdev N -
Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging.
Medchemcomm Volume: 5 Page(s): 432 - 435
04/01/2014 Authors: Liang SH; Yokell DL; Jackson RN; Rice PA; Callahan R; Johnson KA; Alagille D; Tamagnan G; Collier TL; Vasdev N -
Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque.
J Labelled Comp Radiopharm Volume: 57 Page(s): 323 - 331
04/01/2014 Authors: Holland JP; Liang SH; Rotstein BH; Collier TL; Stephenson NA; Greguric I; Vasdev N -
A highly specific probe for sensing hydrogen sulfide in live cells based on copper-initiated fluorogen with aggregation-induced emission characteristics.
Theranostics Volume: 4 Page(s): 1233 - 1238
01/01/2014 Authors: Li X; Yang C; Wu K; Hu Y; Han Y; Liang SH -
First human use of a radiopharmaceutical prepared by continuous-flow microfluidic radiofluorination: proof of concept with the tau imaging agent [18F]T807.
Mol Imaging Volume: 13
01/01/2014 Authors: Liang SH; Yokell DL; Normandin MD; Rice PA; Jackson RN; Shoup TM; Brady TJ; El Fakhri G; Collier TL; Vasdev N -
Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds.
Chem Commun (Camb) Volume: 49 Page(s): 8755 - 8757
10/09/2013 Authors: Liang SH; Collier TL; Rotstein BH; Lewis R; Steck M; Vasdev N -
11CO2 fixation: a renaissance in PET radiochemistry.
Chem Commun (Camb) Volume: 49 Page(s): 5621 - 5629
06/25/2013 Authors: Rotstein BH; Liang SH; Holland JP; Collier TL; Hooker JM; Wilson AA; Vasdev N -
Deprotection and reduction of F-18-labeled compounds by rapid flow hydrogenation
Volume: 56 Page(s): S171 - S171
05/01/2013 Authors: Liang SH; Collier TL; Rotstein B; Lewis R; Steck M; Vasdev N -
Interfacing of a NanoTek microfluidic system with an H-Cube continuous-flow hydrogenation reactor and a GE FXN synthesizer
Volume: 56 Page(s): S473 - S473
05/01/2013 Authors: Collier TL; Liang SH; Vasdev N -
Chiral hypervalent iodine reagents in asymmetric reactions.
Angew Chem Int Ed Engl Volume: 50 Page(s): 11849 - 11851
12/09/2011 Authors: Liang H; Ciufolini MA -
Di-tert-butylisobutylsilyl, another useful protecting group.
Org Lett Volume: 13 Page(s): 4120 - 4123
08/05/2011 Authors: Liang H; Hu L; Corey EJ -
Oxidative spirocyclization of phenolic sulfonamides: scope and applications.
Chemistry Volume: 16 Page(s): 13262 - 13270
11/22/2010 Authors: Liang H; Ciufolini MA -
Tandem phenolic oxidative amidation-intramolecular Diels-Alder reaction: an approach to the himandrine core.
Org Lett Volume: 12 Page(s): 1760 - 1763
04/16/2010 Authors: Liang H; Ciufolini MA -
10-Ethynyl-2,3,6,6a,9,10-hexa-hydro-1H-6,9-methano-pyrrolo[2,1-i][2,1]benzo-thia-zol-10-ol 5,5-dioxide.
Acta Crystallogr Sect E Struct Rep Online Volume: 65 Page(s): o2621
10/03/2009 Authors: Patrick BO; Liang H; Canesi S; Ciufolini MA -
Synthetic studies toward sordarin: building blocks for the terpenoid core and for analogues thereof.
J Org Chem Volume: 74 Page(s): 1587 - 1597
02/20/2009 Authors: Schul A; Liang H; Vors J-P; Ciufolini MA -
Improved procedure for the bimolecular oxidative amidation of phenols.
J Org Chem Volume: 73 Page(s): 4299 - 4301
06/06/2008 Authors: Liang H; Ciufolini MA -
Sordarin, an antifungal agent with a unique mode of action.
Beilstein J Org Chem Volume: 4 Page(s): 31
01/01/2008 Authors: Liang H -
An avenue to the sordarin core adaptable to analog synthesis.
Org Lett Volume: 9 Page(s): 4119 - 4122
10/11/2007 Authors: Liang H; Schul A; Vors J-P; Ciufolini MA