Sohail Khoshnevis
- Department of Biochemistry
Assistant Professor
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Emory University School of Medicine
Biochemistry
1510 Clifton Rd., Room 4015 RRC
Overview
Sohail received his Ph.D. in Molecular Biology from University of Goettingen, Germany in 2010, and followed this by a postdoctoral fellowship in Physical Biochemistry at MPI-BPC. He was a Research Associate at Scripps, before joining Emory as a scientist in 2018.
Research
Publications
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Comparative analyses of disease-linked missense mutations in the RNA exosome modeled in budding yeast reveal distinct functional consequences in translation.
bioRxiv
03/19/2025 Authors: Sterrett MC; Cureton LA; Cohen LN; van Hoof A; Khoshnevis S; Fasken MB; Corbett AH; Ghalei H -
A biallelic variant of the RNA exosome gene, EXOSC4, associated with neurodevelopmental defects impairs RNA exosome function and translation.
J Biol Chem Volume: 300 Page(s): 107571
08/01/2024 Authors: Fasken MB; Leung SW; Cureton LA; Al-Awadi M; Al-Kindy A; van Hoof A; Khoshnevis S; Ghalei H; Al-Maawali A; Corbett AH -
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops).
J Biol Chem Volume: 300 Page(s): 105646
02/01/2024 Authors: de Amorim JL; Leung SW; Haji-Seyed-Javadi R; Hou Y; Yu DS; Ghalei H; Khoshnevis S; Yao B; Corbett AH -
Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity of Candida albicans.
NPJ Antimicrob Resist Volume: 2
01/01/2024 Authors: Nayak A; Khedri A; Chavarria A; Sanders KN; Ghalei H; Khoshnevis S -
A Biallelic Variant of the RNA Exosome Gene EXOSC4 Causes Translational Defects Associated with a Neurodevelopmental Disorder.
medRxiv
10/28/2023 Authors: Fasken MB; Leung SW; Cureton LA; Al-Awadi M; Al-Kindy A; Khoshnevis S; Ghalei H; Al-Maawali A; Corbett AH -
Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity of Candida albicans.
bioRxiv
10/15/2023 Authors: Nayak A; Chavarria A; Sanders KN; Ghalei H; Khoshnevis S -
The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops.
bioRxiv
04/17/2023 Authors: de Amorim JL; Leung SW; Haji-Seyed-Javadi R; Hou Y; Yu DS; Ghalei H; Khoshnevis S; Yao B; Corbett AH -
RNA structural probing of guanine and uracil nucleotides in yeast.
PLoS One Volume: 18 Page(s): e0288070
01/01/2023 Authors: Xiao K; Ghalei H; Khoshnevis S -
Studies of mutations of assembly factor Hit1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome.
J Biol Chem Volume: 298 Page(s): 102261
09/01/2022 Authors: Dreggors-Walker RE; Cohen LN; Khoshnevis S; Marchand V; Motorin Y; Ghalei H -
Ribosomal RNA 2'-O-methylations regulate translation by impacting ribosome dynamics.
Proc Natl Acad Sci U S A Volume: 119 Page(s): e2117334119
03/22/2022 Authors: Khoshnevis S; Dreggors-Walker RE; Marchand V; Motorin Y; Ghalei H