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Profile

Scott Jenks

  • Department of Medicine
    Assistant Professor
  • scott.jenks@emory.edu
Head shot of Scott Jenks

Overview

Dr. Jenks grew up in northeastern Wisconsin, where he attended Ripon College from 1990-1994. During his undergraduate coursework, he became very interested in the complexity and interconnectedness of the immune system and decided to pursue a doctoral degree in immunology. During his doctoral work at the University of Chicago, he studied with Dr. Jim Miller and demonstrated that T-cell co-stimulatory signals can influence Th2 differentiation.

After receiving his PhD, Dr. Jenks did postdoctoral studies in antigen processing and immune-dominance in the laboratory of Dr. Andrea Sant at the University of Rochester. In 2005, he joined the laboratory of Dr. Iaki Sanz, where he transitioned from studying mouse models of immunity to studying human disease directly, a change that has been both challenging and rewarding. In 2012, Dr. Sanz relocated his laboratory to Emory University, and Dr. Jenks chose to join him. He presently holds an academic appointment as instructor of medicine in the Emory University Division of Rheumatology.

Dr. Jenk's research is focused on human B cell biology in relation to auto-immune disease. He is excited that recently developed techniques are now making it possible to understand the complexity that has fascinated him throughout his studies.

Academic Appointment

  • Instructor of Medicine, Medicine - Rheumatology, Emory University School of Medicine

Education

Degrees

  • PhD from University of Chicago
  • BS from Ripon College

Research

Focus

  • The role of B cells in SLE pathology, University of Rochester and Emory Univeristy Mentor: Dr. Iaki Sanz In Dr. Sanzs lab I have defined the prevalence of specific auto-antibodies reactive against apoptotic cells and the relationship of these antibodies to other autoreactive specificities and disease. I am also studying the origins and pathological role of specific B cell memory subsets that are expanded in many SLE patients.
  • Immunodominance and DM editing, University of Chicago and University of Rochester, Mentor Dr. Andrea Sant, During this post doctoral research I determined the role of the cofactor DM in determining what CD4 T cell epitopes become immunodominant in response to a complex protein antigen. This research has implications for vaccine design.
  • LFA-1 costimulation inhibits T helper type two responses. Doctoral dissertation, Mentor: Dr. Jim Miller, University of Chicago
  • The role of HSP70 in protection from intestinal epithelial cell injury, Mentor Dr.Eugene Chang, University of Chicago

Publications

  • Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19.
    Sci Transl Med Volume: 16 Page(s): eadq1789
    11/06/2024 Authors: Babcock BR; Kosters A; Eddins DJ; Donaire MSB; Sarvadhavabhatla S; Pae V; Beltran F; Murray VW; Gill G; Xie G
  • High refresh rate display for natural monocular viewing in AOSLO psychophysics experiments.
    Opt Express Volume: 32 Page(s): 31142 - 31161
    08/26/2024 Authors: Moon B; Linebach G; Yang A; Jenks SK; Rucci M; Poletti M; Rolland JP
  • Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria.
    Immunity Volume: 57 Page(s): 1769 - 1779.e4
    08/13/2024 Authors: Hagadorn KA; Peterson ME; Kole H; Scott B; Skinner J; Diouf A; Takashima E; Ongoiba A; Doumbo S; Doumtabe D
  • Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus.
    Nat Commun Volume: 15 Page(s): 1899
    03/01/2024 Authors: Chen W; Hong S-H; Jenks SA; Anam FA; Tipton CM; Woodruff MC; Hom JR; Cashman KS; Faliti CE; Wang X
  • Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID.
    Nat Commun Volume: 14 Page(s): 4201
    07/14/2023 Authors: Woodruff MC; Bonham KS; Anam FA; Walker TA; Faliti CE; Ishii Y; Kaminski CY; Ruunstrom MC; Cooper KR; Truong AD
  • SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival Programs.
    Res Sq
    06/27/2023 Authors: Chen W; Hong S-H; Jenks SA; Anam FA; Tipton CM; Woodruff MC; Hom JR; Cashman KS; Faliti CE; Wang X
  • Dysregulated naive B cells and de novo autoreactivity in severe COVID-19.
    Nature Volume: 611 Page(s): 139 - 147
    11/01/2022 Authors: Woodruff MC; Ramonell RP; Haddad NS; Anam FA; Rudolph ME; Walker TA; Truong AD; Dixit AN; Han JE; Cabrera-Mora M
  • Altered B cell phenotype and CD27+ memory B cells are associated with clinical features and environmental exposure in Colombian systemic lupus erythematosus patients.
    Front Med (Lausanne) Volume: 9 Page(s): 950452
    01/01/2022 Authors: Hurtado C; Rojas-Gualdrn DF; Urrego R; Cashman K; Vsquez-Trespalacios EM; Daz-Coronado JC; Rojas M; Jenks S; Vsquez G; Sanz I
  • B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus.
    Ann Rheum Dis Volume: 80 Page(s): 1190 - 1200
    09/01/2021 Authors: Jenks SA; Wei C; Bugrovsky R; Hill A; Wang X; Rossi FM; Cashman K; Woodruff MC; Aspey LD; Lim SS
  • Relaxed peripheral tolerance drives broad de novo autoreactivity in severe COVID-19.
    medRxiv
    07/27/2021 Authors: Woodruff MC; Ramonell RP; Saini AS; Haddad NS; Anam FA; Rudolph ME; Bugrovsky R; Hom J; Cashman KS; Nguyen DC
  • Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
    Nat Immunol Volume: 21 Page(s): 1506 - 1516
    12/01/2020 Authors: Woodruff MC; Ramonell RP; Nguyen DC; Cashman KS; Saini AS; Haddad NS; Ley AM; Kyu S; Howell JC; Ozturk T
  • DNA methylation changes on immune cells in Systemic Lupus Erythematosus.
    Autoimmunity Volume: 53 Page(s): 114 - 121
    05/01/2020 Authors: Hurtado C; Acevedo Senz LY; Vsquez Trespalacios EM; Urrego R; Jenks S; Sanz I; Vsquez G
  • Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
    Immunity Volume: 52 Page(s): 203
    01/14/2020 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R
  • Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.
    Immunol Rev Volume: 292 Page(s): 76 - 89
    11/01/2019 Authors: Cashman KS; Jenks SA; Woodruff MC; Tomar D; Tipton CM; Scharer CD; Eun-Hyung Lee F; Boss JM; Sanz I
  • Epigenetic programming underpins B cell dysfunction in human SLE.
    Nat Immunol Volume: 20 Page(s): 1071 - 1082
    08/01/2019 Authors: Scharer CD; Blalock EL; Mi T; Barwick BG; Jenks SA; Deguchi T; Cashman KS; Neary BE; Patterson DG; Hicks SL
  • IFN induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation.
    Elife Volume: 8
    05/15/2019 Authors: Zumaquero E; Stone SL; Scharer CD; Jenks SA; Nellore A; Mousseau B; Rosal-Vela A; Botta D; Bradley JE; Wojciechowski W
  • Epigenetic programming underpins B cell dysfunction in human SLE
    Volume: 202
    05/01/2019 Authors: Scharer C; Blalock E; Mi T; Barwick B; Jenks S; Neary B; Patterson D; Deguchi T; Lee E-H; Wei C
  • Extrafollicular responses in humans and SLE.
    Immunol Rev Volume: 288 Page(s): 136 - 148
    03/01/2019 Authors: Jenks SA; Cashman KS; Woodruff MC; Lee FE-H; Sanz I
  • Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations.
    Front Immunol Volume: 10 Page(s): 2458
    01/01/2019 Authors: Sanz I; Wei C; Jenks SA; Cashman KS; Tipton C; Woodruff MC; Hom J; Lee FE-H
  • Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
    Immunity Volume: 49 Page(s): 725 - 739.e6
    10/16/2018 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R
  • Relationships and transitions between B and plasma cell populations in SLE patients
    Volume: 86 Page(s): 325 - 325
    10/01/2017 Authors: Goldenberg R; Tipton C; Jenks S; Lee E-HF; Sanz I; Mehr R
  • The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.
    J Immunol Volume: 197 Page(s): 3841 - 3849
    11/15/2016 Authors: Hart GT; Akkaya M; Chida AS; Wei C; Jenks SA; Tipton C; He C; Wendel BS; Skinner J; Arora G
  • Polychromatic flow cytometry in evaluating rheumatic disease patients.
    Arthritis Res Ther Volume: 17 Page(s): 561
    12/01/2015 Authors: Wei C; Jenks S; Sanz I
  • Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus.
    Nat Immunol Volume: 16 Page(s): 755 - 765
    07/01/2015 Authors: Tipton CM; Fucile CF; Darce J; Chida A; Ichikawa T; Gregoretti I; Schieferl S; Hom J; Jenks S; Feldman RJ
  • Polychromatic flow cytometry in evaluating rheumatic disease patients.
    Arthritis Res Ther Volume: 17 Page(s): 46
    03/05/2015 Authors: Wei C; Jenks S; Sanz I
  • Primary Sjgren's syndrome is characterized by distinct phenotypic and transcriptional profiles of IgD+ unswitched memory B cells.
    Arthritis Rheumatol Volume: 66 Page(s): 2558 - 2569
    09/01/2014 Authors: Roberts MEP; Kaminski D; Jenks SA; Maguire C; Ching K; Burbelo PD; Iadarola MJ; Rosenberg A; Coca A; Anolik J
  • 9G4+ autoantibodies are an important source of apoptotic cell reactivity associated with high levels of disease activity in systemic lupus erythematosus.
    Arthritis Rheum Volume: 65 Page(s): 3165 - 3175
    12/01/2013 Authors: Jenks SA; Palmer EM; Marin EY; Hartson L; Chida AS; Richardson C; Sanz I
  • Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus.
    J Immunol Volume: 191 Page(s): 4926 - 4939
    11/15/2013 Authors: Richardson C; Chida AS; Adlowitz D; Silver L; Fox E; Jenks SA; Palmer E; Wang Y; Heimburg-Molinaro J; Li Q-Z
  • Understanding The Stimulatory Pathways Responsible For Naive B Cell Activation In Systemic Lupus Erythematosus
    Volume: 65 Page(s): S13 - S13
    10/01/2013 Authors: Blalock E; Scharer C; Jenks S; Boss J; Sanz I
  • IgD-CD27-B Cells From Systemic Lupus Erythematous Patients Have Increased Expression Of Genes Involved In RNA Sensing and Toll-Like Receptor 3 Signaling Pathways
    Volume: 65 Page(s): S12 - S13
    10/01/2013 Authors: Jenks S; Ramos E; Sanz I
  • Chromatin Binding In SLE Patients Correlates With The Intensity Of Apoptotic Binding By 9G4+B Cells.
    Volume: 65 Page(s): S687 - S687
    10/01/2013 Authors: Chida AS; Li Q-Z; Mohan C; Wang Y; Jenks S; Hartson L; Sanz I
  • Plasma Cells In Acute Systemic Lupus Erythematosus Flares Are Characterized By a Highly Diversified Repertoire Accentuated By Clonal Expansions Of VH4-34 Antibodies
    Volume: 65 Page(s): S10 - S10
    10/01/2013 Authors: Tipton C; Fucile C; Rosenberg A; Jenks S; Hom J; Lee FE-H; Sanz I
  • Protein kinase C is required for lupus development in Sle mice.
    Arthritis Rheum Volume: 65 Page(s): 1022 - 1031
    04/01/2013 Authors: Oleksyn D; Pulvino M; Zhao J; Misra R; Vosoughi A; Jenks S; Tipton C; Lund F; Schwartz G; Goldman B
  • Molecular Analysis of 9G4+Antibodies in Systemic Lupus Erythematosus.
    Volume: 64 Page(s): S296 - S296
    10/01/2012 Authors: Richardson C; Chida AS; Fox E; Silver L; Adlowitz DG; Jenks S; Palmer E; Tipton C; Sanz I
  • Altered B cell receptor signaling in human systemic lupus erythematosus.
    Autoimmun Rev Volume: 8 Page(s): 209 - 213
    01/01/2009 Authors: Jenks SA; Sanz I
  • Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design.
    J Immunol Volume: 181 Page(s): 3039 - 3048
    09/01/2008 Authors: Weaver JM; Lazarski CA; Richards KA; Chaves FA; Jenks SA; Menges PR; Sant AJ
  • CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen.
    J Immunol Volume: 180 Page(s): 2149 - 2157
    02/15/2008 Authors: Larkin J; Rankin AL; Picca CC; Riley MP; Jenks SA; Sant AJ; Caton AJ
  • An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice.
    J Immunol Volume: 180 Page(s): 1619 - 1633
    02/01/2008 Authors: Menges PR; Jenks SA; Bikoff EK; Friedmann DR; Knowlden ZAG; Sant AJ
  • The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes.
    Immunol Rev Volume: 207 Page(s): 261 - 278
    10/01/2005 Authors: Sant AJ; Chaves FA; Jenks SA; Richards KA; Menges P; Weaver JM; Lazarski CA
  • The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance.
    Immunity Volume: 23 Page(s): 29 - 40
    07/01/2005 Authors: Lazarski CA; Chaves FA; Jenks SA; Wu S; Richards KA; Weaver JM; Sant AJ
  • LFA-1 co-stimulation inhibits T(h)2 differentiation by down-modulating IL-4 responsiveness.
    Int Immunol Volume: 17 Page(s): 315 - 323
    03/01/2005 Authors: Jenks SA; Eisfelder BJ; Miller J
  • Inhibition of IL-4 responses after T cell priming in the context of LFA-1 costimulation is not reversed by restimulation in the presence of CD28 costimulation.
    J Immunol Volume: 164 Page(s): 72 - 78
    01/01/2000 Authors: Jenks SA; Miller J
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