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Shawn Hochman PhD

Department of Cell Biology
Professor

(404) 712-3131
shochm2@emory.edu

Academic Appointment

Education

Degrees

PhD from University of Manitoba
B.Sc.(Hons.) from University of Manitoba

Research

Focus

Neuromodulation and plasticity of spinal cord functional systems involved in the control of sensory, motor and autonomic pathways. Restless Legs Syndrome (RLS). Developing an animal model of the relaxation response.

Publications

Optogenetic methods to stimulate gamma motor neuron axons ex vivo.
Exp Physiol
02/03/2025 Authors: Karekal A; Mandawe R; Chun C; Byri SK; Cheline D; Ortiz S; Hochman S; Wilkinson KA
Emergent epileptiform activity in spinal sensory circuits drives ectopic bursting in afferent axons and sensory dysfunction after cord injury.
Pain Volume: 166 Page(s): e27 - e35
02/01/2025 Authors: Bryson M; Kloefkorn H; Idlett-Ali S; Carrasco DI; Noble DJ; Martin K; Sawchuk MA; Au Yong N; Garraway SM; Hochman S
Relating Spinal Injury-Induced Neuropathic Pain and Spontaneous Afferent Activity to Sleep and Respiratory Dysfunction.
J Neurotrauma Volume: 40 Page(s): 2654 - 2666
12/01/2023 Authors: Idlett-Ali S; Kloefkorn H; Goolsby W; Hochman S
Emergent epileptiform activity drives spinal sensory circuits to generate ectopic bursting in intraspinal afferent axons after cord injury.
bioRxiv
07/12/2023 Authors: Bryson M; Kloefkorn H; Idlett-Ali S; Martin K; Garraway SM; Hochman S
Effect of temperature and geometry on action potential propagation failure at axonal branch points in sympathetic preganglionic neurons
Volume: 51 Page(s): S80 - S80
01/01/2023 Authors: Wu Y; Halder M; Sokoloff A; Li Y; Sawchuk M; Hochman S; Prinz AA
Scoring sleep using respiration and movement-based features.
MethodsX Volume: 9 Page(s): 101682
01/01/2022 Authors: Kloefkorn H; Aiani LM; Hochman S; Pedersen NP
Sympathetic postganglionic neurons as a potential locus of modulation and plasticity in the sympathetic pathway
Volume: 49 Page(s): S148 - S149
12/01/2021 Authors: Chang NH; McKinnon M; Hochman S; Prinz AA
Enhanced ensemble computational models of mouse thoracic sympathetic postganglionic neurons with offline compensation of electrode artifacts
Volume: 49 Page(s): S147 - S147
12/01/2021 Authors: Pusuluri K; Li Y; Hochman S; Prinz AA
Isolation and Electrophysiology of Murine Sympathetic Postganglionic Neurons in the Thoracic Paravertebral Ganglia.
Bio Protoc Volume: 11 Page(s): e4189
10/20/2021 Authors: Halder M; McKinnon ML; Li Y; Wenner P; Hochman S
Development of an Optogenetic Method to Stimulate Gamma Motor Neurons In Vitro
Volume: 35
05/01/2021 Authors: Cheline D; Karekal A; Mandawe R; Byri S; Hochman S; Wilkinson K
Nicotinic receptor modulation of primary afferent excitability with selective regulation of A-mediated spinal actions.
J Neurophysiol Volume: 125 Page(s): 568 - 585
02/01/2021 Authors: Shreckengost J; Halder M; Mena-Avila E; Garcia-Ramirez DL; Quevedo J; Hochman S
Noninvasive three-state sleep-wake staging in mice using electric field sensors.
J Neurosci Methods Volume: 344 Page(s): 108834
10/01/2020 Authors: Kloefkorn H; Aiani LM; Lakhani A; Nagesh S; Moss A; Goolsby W; Rehg JM; Pedersen NP; Hochman S
The activation of D2 and D3 receptor subtypes inhibits pathways mediating primary afferent depolarization (PAD) in the mouse spinal cord.
Neurosci Lett Volume: 736 Page(s): 135257
09/25/2020 Authors: Milla-Cruz JJ; Mena-Avila E; Calvo JR; Hochman S; Villaln CM; Quevedo JN
Activation of -adrenoceptors depresses synaptic transmission of myelinated afferents and inhibits pathways mediating primary afferent depolarization (PAD) in the in vitro mouse spinal cord.
Exp Brain Res Volume: 238 Page(s): 1293 - 1303
05/01/2020 Authors: Mena-Avila E; Milla-Cruz JJ; Calvo JR; Hochman S; Villaln CM; Arias-Montao J-A; Quevedo JN
Disc degeneration induces a mechano-sensitization of disc afferent nerve fibers that associates with low back pain.
Osteoarthritis Cartilage Volume: 27 Page(s): 1608 - 1617
11/01/2019 Authors: Park EH; Moon SW; Suh HR; Hochman S; Lee M-G; Kim YI; Jang IT; Han HC
Assessment of axonal recruitment using model-guided preclinical spinal cord stimulation in the ex vivo adult mouse spinal cord.
J Neurophysiol Volume: 122 Page(s): 1406 - 1420
10/01/2019 Authors: Idlett S; Halder M; Zhang T; Quevedo J; Brill N; Gu W; Moffitt M; Hochman S
Dramatically Amplified Thoracic Sympathetic Postganglionic Excitability and Integrative Capacity Revealed with Whole-Cell Patch-Clamp Recordings.
eNeuro Volume: 6
01/01/2019 Authors: McKinnon ML; Tian K; Li Y; Sokoloff AJ; Galvin ML; Choi MH; Prinz A; Hochman S
Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation.
Front Physiol Volume: 10 Page(s): 1176
01/01/2019 Authors: Noble DJ; Hochman S
Editorial: Neuromodulatory Control of Spinal Function in Health and Disease.
Front Neural Circuits Volume: 13 Page(s): 84
01/01/2019 Authors: Noga BR; Hochman S; Hultborn H
Unobtrusive Heartbeat Detection from Mice Using Sensors Embedded in the Nest.
Annu Int Conf IEEE Eng Med Biol Soc Volume: 2018 Page(s): 1604 - 1607
07/01/2018 Authors: Gurel NZ; Jeong HK; Kloefkorn H; Hochman S; Inan OT
Evidence Supporting a Role for Autonomic Modulation of C-Low Threshold Mechanoreceptors
Volume: 32
04/01/2018 Authors: Provost M; Goolsby B; Hochman S
Plasticity of sympathetic post-ganglionic neuron after spinal cord injury
Volume: 32
04/01/2018 Authors: Li Y; McKinnon ML; Hochman S
Spinal Contusion Injury Induces Long Lasting Changes in Home Cage Activity and Respiration which Correlate with Spontaneous and Evoked Indices of Neuropathic Pain
Volume: 32
04/01/2018 Authors: Kloefkorn H; Idlett S; Halder M; Hochman S
Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.
J Neurophysiol Volume: 118 Page(s): 2956 - 2974
12/01/2017 Authors: Ziskind-Conhaim L; Hochman S
Use of electric field sensors for recording respiration, heart rate, and stereotyped motor behaviors in the rodent home cage.
J Neurosci Methods Volume: 277 Page(s): 88 - 100
02/01/2017 Authors: Noble DJ; MacDowell CJ; McKinnon ML; Neblett TI; Goolsby WN; Hochman S
Slow Breathing Can Be Operantly Conditioned in the Rat and May Reduce Sensitivity to Experimental Stressors.
Front Physiol Volume: 8 Page(s): 854
01/01/2017 Authors: Noble DJ; Goolsby WN; Garraway SM; Martin KK; Hochman S
Metabolic recruitment of spinal locomotion: intracellular neuromodulation by trace amines and their receptors.
Neural Regen Res Volume: 10 Page(s): 1940 - 1942
12/01/2015 Authors: Hochman S
An in vitro adult mouse muscle-nerve preparation for studying the firing properties of muscle afferents.
J Vis Exp Page(s): 51948
09/24/2014 Authors: Franco JA; Kloefkorn HE; Hochman S; Wilkinson KA
Serotonin, dopamine and noradrenaline adjust actions of myelinated afferents via modulation of presynaptic inhibition in the mouse spinal cord.
PLoS One Volume: 9 Page(s): e89999
01/01/2014 Authors: Garca-Ramrez DL; Calvo JR; Hochman S; Quevedo JN
Anatomical and functional evidence for trace amines as unique modulators of locomotor function in the mammalian spinal cord.
Front Neural Circuits Volume: 8 Page(s): 134
01/01/2014 Authors: Gozal EA; O'Neill BE; Sawchuk MA; Zhu H; Halder M; Chou C-C; Hochman S
Force-sensitive afferents recruited during stance encode sensory depression in the contralateral swinging limb during locomotion.
Ann N Y Acad Sci Volume: 1279 Page(s): 103 - 113
03/01/2013 Authors: Hochman S; Hayes HB; Speigel I; Chang Y-H
Enabling techniques for in vitro studies on mammalian spinal locomotor mechanisms.
Front Biosci (Landmark Ed) Volume: 17 Page(s): 2158 - 2180
06/01/2012 Authors: Hochman S; Gozal EA; Hayes HB; Anderson JT; DeWeerth SP; Chang Y-H
Stance-phase force on the opposite limb dictates swing-phase afferent presynaptic inhibition during locomotion.
J Neurophysiol Volume: 107 Page(s): 3168 - 3180
06/01/2012 Authors: Hayes HB; Chang Y-H; Hochman S
Changes in mouse serotonin and dopamine receptor labeling in the intermediolateral nucleus after spinal cord injury
Volume: 26
04/01/2012 Authors: O'Neill BE; Hochman S; Sawchuk M; Zimmerman A
Isolating a role for deep breathing in reducing activation of stress-related limbic circuits
Volume: 26
04/01/2012 Authors: Noble DJ; Sawchuk M; O'Neill B; Hochman S
Acute inflammation alters the response to stretch in mouse extensor digitorum longus muscle afferents
Volume: 26
04/01/2012 Authors: Wilkinson KA; Hochman S
Monoaminergic modulation of spinal viscero-sympathetic function in the neonatal mouse thoracic spinal cord.
PLoS One Volume: 7 Page(s): e47213
01/01/2012 Authors: Zimmerman AL; Sawchuk M; Hochman S
Characterization of muscle spindle afferents in the adult mouse using an in vitro muscle-nerve preparation.
PLoS One Volume: 7 Page(s): e39140
01/01/2012 Authors: Wilkinson KA; Kloefkorn HE; Hochman S
Long-term patch recordings from adult spinal neurons herald new era of opportunity.
J Neurophysiol Volume: 106 Page(s): 2794 - 2795
12/01/2011 Authors: Hochman S
Characterization of adult mouse muscle spindle afferents in an in vitro isolated muscle nerve preparation
Volume: 25
04/01/2011 Authors: Wilkinson K; Kloefkorn H; Hochman S
Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and 2 ligands.
Eur Neurol Volume: 66 Page(s): 18 - 29
01/01/2011 Authors: Thorpe AJ; Clair A; Hochman S; Clemens S
Selective stimulation of the spinal cord surface using a stretchable microelectrode array.
Front Neuroeng Volume: 4 Page(s): 5
01/01/2011 Authors: Meacham KW; Guo L; Deweerth SP; Hochman S
A PDMS-based conical-well microelectrode array for surface stimulation and recording of neural tissues.
IEEE Trans Biomed Eng Volume: 57 Page(s): 2485 - 2494
10/01/2010 Authors: Guo L; Meacham KW; Hochman S; DeWeerth SP
Presynaptic inhibition of primary afferents by depolarization: observations supporting nontraditional mechanisms.
Ann N Y Acad Sci Volume: 1198 Page(s): 140 - 152
06/01/2010 Authors: Hochman S; Shreckengost J; Kimura H; Quevedo J
Bicuculline-sensitive primary afferent depolarization remains after greatly restricting synaptic transmission in the mammalian spinal cord.
J Neurosci Volume: 30 Page(s): 5283 - 5288
04/14/2010 Authors: Shreckengost J; Calvo J; Quevedo J; Hochman S
Heterogeneity of membrane properties in sympathetic preganglionic neurons of neonatal mice: evidence of four subpopulations in the intermediolateral nucleus.
J Neurophysiol Volume: 103 Page(s): 490 - 498
01/01/2010 Authors: Zimmerman A; Hochman S
Phenotypic diversity and expression of GABAergic inhibitory interneurons during postnatal development in lumbar spinal cord of glutamic acid decarboxylase 67-green fluorescent protein mice.
Neuroscience Volume: 163 Page(s): 909 - 919
10/20/2009 Authors: Dougherty KJ; Sawchuk MA; Hochman S
An in vitro spinal cord-hindlimb preparation for studying behaviorally relevant rat locomotor function.
J Neurophysiol Volume: 101 Page(s): 1114 - 1122
02/01/2009 Authors: Hayes HB; Chang Y-H; Hochman S
Unaltered D1, D2, D4, and D5 dopamine receptor mRNA expression and distribution in the spinal cord of the D3 receptor knockout mouse.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol Volume: 194 Page(s): 957 - 962
11/01/2008 Authors: Zhu H; Clemens S; Sawchuk M; Hochman S
Depression of spinal sensory transmission during REM sleep: dopaminergic involvement and insights into restless legs syndrome. Focus on "state-dependent changes in glutamate, glycine, GABA, and dopamine levels in cat lumbar spinal cord".
J Neurophysiol Volume: 100 Page(s): 549 - 550
08/01/2008 Authors: Hochman S
Spinal cord injury causes plasticity in a subpopulation of lamina I GABAergic interneurons.
J Neurophysiol Volume: 100 Page(s): 212 - 223
07/01/2008 Authors: Dougherty KJ; Hochman S
Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function.
Gastroenterology Volume: 134 Page(s): 1424 - 1435
05/01/2008 Authors: Anitha M; Joseph I; Ding X; Torre ER; Sawchuk MA; Mwangi S; Hochman S; Sitaraman SV; Anania F; Srinivasan S
A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord.
Biomed Microdevices Volume: 10 Page(s): 259 - 269
04/01/2008 Authors: Meacham KW; Giuly RJ; Guo L; Hochman S; DeWeerth SP
Expression and distribution of all dopamine receptor subtypes (D(1)-D(5)) in the mouse lumbar spinal cord: a real-time polymerase chain reaction and non-autoradiographic in situ hybridization study.
Neuroscience Volume: 149 Page(s): 885 - 897
11/23/2007 Authors: Zhu H; Clemens S; Sawchuk M; Hochman S
Spinal cord.
Curr Biol Volume: 17 Page(s): R950 - R955
11/20/2007 Authors: Hochman S
Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective.
Neurology Volume: 67 Page(s): 125 - 130
07/11/2006 Authors: Clemens S; Rye D; Hochman S
Noradrenaline unmasks novel self-reinforcing motor circuits within the mammalian spinal cord.
J Neurosci Volume: 26 Page(s): 5920 - 5928
05/31/2006 Authors: Machacek DW; Hochman S
Divergence between motoneurons: gene expression profiling provides a molecular characterization of functionally discrete somatic and autonomic motoneurons.
Physiol Genomics Volume: 24 Page(s): 276 - 289
02/14/2006 Authors: Cui D; Dougherty KJ; Machacek DW; Sawchuk M; Hochman S; Baro DJ
Properties of mouse spinal lamina I GABAergic interneurons.
J Neurophysiol Volume: 94 Page(s): 3221 - 3227
11/01/2005 Authors: Dougherty KJ; Sawchuk MA; Hochman S
Serotonin 5-HT2 receptors induce a long-lasting facilitation of spinal reflexes independent of ionotropic receptor activity.
J Neurophysiol Volume: 94 Page(s): 2867 - 2877
10/01/2005 Authors: Shay BL; Sawchuk M; Machacek DW; Hochman S
Reversal of the circadian expression of tyrosine-hydroxylase but not nitric oxide synthase levels in the spinal cord of dopamine D3 receptor knockout mice.
Neuroscience Volume: 133 Page(s): 353 - 357
01/01/2005 Authors: Clemens S; Sawchuk MA; Hochman S
Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice.
J Neurosci Volume: 24 Page(s): 11337 - 11345
12/15/2004 Authors: Clemens S; Hochman S
Human immunodeficiency virus type 1 Tat protein directly activates neuronal N-methyl-D-aspartate receptors at an allosteric zinc-sensitive site.
J Neurovirol Volume: 9 Page(s): 399 - 403
06/01/2003 Authors: Song L; Nath A; Geiger JD; Moore A; Hochman S
Functional motor neurons differentiating from mouse multipotent spinal cord precursor cells in culture and after transplantation into transected sciatic nerve.
J Neurosurg Volume: 98 Page(s): 1094 - 1103
05/01/2003 Authors: MacDonald SC; Fleetwood IG; Hochman S; Dodd JG; Cheng GKW; Jordan LM; Brownstone RM
A population of oligodendrocytes derived from multipotent neural precursor cells expresses a cholinergic phenotype in culture and responds to ciliary neurotrophic factor.
J Neurosci Res Volume: 68 Page(s): 255 - 264
05/01/2002 Authors: MacDonald SC; Simcoff R; Jordan LM; Dodd JG; Cheng KW; Hochman S
The isolated rat spinal cord as an in vitro model to study the pharmacologic control of myoclonic-like activity.
Adv Neurol Volume: 89 Page(s): 275 - 287
01/01/2002 Authors: Cowley KC; Cina C; Schmidt BJ; Hochman S
Serotonin alters multi-segmental convergence patterns in spinal cord deep dorsal horn and intermediate laminae neurons in an in vitro young rat preparation.
Pain Volume: 95 Page(s): 7 - 14
01/01/2002 Authors: Shay BL; Hochman S
Serotonin 5-HT(2) receptor activation induces a long-lasting amplification of spinal reflex actions in the rat.
J Physiol Volume: 537 Page(s): 201 - 207
11/15/2001 Authors: Machacek DW; Garraway SM; Shay BL; Hochman S
Modulatory actions of serotonin, norepinephrine, dopamine, and acetylcholine in spinal cord deep dorsal horn neurons.
J Neurophysiol Volume: 86 Page(s): 2183 - 2194
11/01/2001 Authors: Garraway SM; Hochman S
Neurogenesis in postnatal mouse dorsal root ganglia.
Exp Neurol Volume: 172 Page(s): 60 - 69
11/01/2001 Authors: Namaka MP; Sawchuk M; MacDonald SC; Jordan LM; Hochman S
Serotonin increases the incidence of primary afferent-evoked long-term depression in rat deep dorsal horn neurons.
J Neurophysiol Volume: 85 Page(s): 1864 - 1872
05/01/2001 Authors: Garraway SM; Hochman S
Pharmacological characterization of serotonin receptor subtypes modulating primary afferent input to deep dorsal horn neurons in the neonatal rat.
Br J Pharmacol Volume: 132 Page(s): 1789 - 1798
04/01/2001 Authors: Garraway SM; Hochman S
Diffuse distribution of sulforhodamine-labeled neurons during serotonin-evoked locomotion in the neonatal rat thoracolumbar spinal cord.
J Comp Neurol Volume: 423 Page(s): 590 - 602
08/07/2000 Authors: Cina C; Hochman S
Facilitation of NMDA-mediated calcium flux by the HIV-1 protein Tat involves tyrosine kinase-dependent modulation of the zinc site an NMDA receptors.
JOURNAL OF NEUROCHEMISTRY Volume: 74 Page(s): S19 - S19
01/01/2000 Authors: Haughey NJ; Mattson MP; Nath A; Hochman S; Geiger JD
NMDA receptor-mediated oscillatory properties: potential role in rhythm generation in the mammalian spinal cord.
Ann N Y Acad Sci Volume: 860 Page(s): 189 - 202
11/16/1998 Authors: Schmidt BJ; Hochman S; MacLean JN
Thin slice CNS explants maintained on collagen-coated culture dishes.
J Neurosci Methods Volume: 80 Page(s): 65 - 74
03/13/1998 Authors: Parsley CP; Cheng KW; Song L; Hochman S
Whole cell recordings of lumbar motoneurons during locomotor-like activity in the in vitro neonatal rat spinal cord.
J Neurophysiol Volume: 79 Page(s): 743 - 752
02/01/1998 Authors: Hochman S; Schmidt BJ
Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein.
Neuroscience Volume: 82 Page(s): 97 - 106
01/01/1998 Authors: Cheng J; Nath A; Knudsen B; Hochman S; Geiger JD; Ma M; Magnuson DS
NMDA receptor activation triggers voltage oscillations, plateau potentials and bursting in neonatal rat lumbar motoneurons in vitro.
Eur J Neurosci Volume: 9 Page(s): 2702 - 2711
12/01/1997 Authors: MacLean JN; Schmidt BJ; Hochman S
Membrane properties of deep dorsal horn neurons from neonatal rat spinal cord in vitro.
Brain Res Volume: 767 Page(s): 214 - 219
09/05/1997 Authors: Hochman S; Garraway SM; Pockett S
Primary afferent-evoked synaptic plasticity in deep dorsal horn neurons from neonatal rat spinal cord in vitro.
Neurosci Lett Volume: 230 Page(s): 61 - 64
07/11/1997 Authors: Garraway SM; Pockett S; Hochman S
A variation of the tissue print technique for studying isolated spinal cord cells in situ.
Neurosci Lett Volume: 223 Page(s): 85 - 88
02/21/1997 Authors: MacDonald SC; Hochman S
The human immunodeficiency virus type-1 protein Tat causes excitation of neuronal cell membranes, increases in intracellular calcium, and apoptosis
NEUROLOGY Volume: 46 Page(s): 1002 - 1002
02/01/1996 Authors: Nath A; Ma MH; Cheng JG; Haughey N; Magnuson DSK; Hochman S; Geiger JD
Lamina VII neurons are rhythmically active during locomotor-like activity in the neonatal rat spinal cord.
Neurosci Lett Volume: 197 Page(s): 9 - 12
09/01/1995 Authors: MacLean JN; Hochman S; Magnuson DS
TTX-resistant NMDA receptor-mediated voltage oscillations in mammalian lumbar motoneurons.
J Neurophysiol Volume: 72 Page(s): 2559 - 2562
11/01/1994 Authors: Hochman S; Jordan LM; Schmidt BJ
N-methyl-D-aspartate receptor-mediated voltage oscillations in neurons surrounding the central canal in slices of rat spinal cord.
J Neurophysiol Volume: 72 Page(s): 565 - 577
08/01/1994 Authors: Hochman S; Jordan LM; MacDonald JF
Effects of chronic spinalization on ankle extensor motoneurons. III. Composite Ia EPSPs in motoneurons separated into motor unit types.
J Neurophysiol Volume: 71 Page(s): 1480 - 1490
04/01/1994 Authors: Hochman S; McCrea DA
Effects of chronic spinalization on ankle extensor motoneurons. II. Motoneuron electrical properties.
J Neurophysiol Volume: 71 Page(s): 1468 - 1479
04/01/1994 Authors: Hochman S; McCrea DA
Effects of chronic spinalization on ankle extensor motoneurons. I. Composite monosynaptic Ia EPSPs in four motoneuron pools.
J Neurophysiol Volume: 71 Page(s): 1452 - 1467
04/01/1994 Authors: Hochman S; McCrea DA
Membrane electrical properties of external urethral and external anal sphincter somatic motoneurons in the decerebrate cat.
Neurosci Lett Volume: 127 Page(s): 87 - 90
06/10/1991 Authors: Hochman S; Fedirchuk B; Shefchyk SJ

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