Shannon Gourley PhD

Department of Pediatrics
Associate Professor

(404) 727-2482
shannon.l.gourley@emory.edu

Academic Appointment

Training Faculty, Training Program in the Neurobiology of Drug Abuse at Emory, Emory School of Medicine
Training Faculty, Emory Graduate Program in Neuroscience
Research Faculty, Emory National Primate Research Center
Assistant Professor, Department of Pediatrics, Emory School of Medicine

Education

Degrees

PhD from Yale University
BS from Tufts University
MA from New York University

Research

Focus

We study stress hormone and psychostimulant dynamics, particularly in adolscent populations. We utilize murine models of depression and addiction, appetitive conditioning, confocal microscopy, viral-mediated gene silencing, and pharmacological strategies to better understand how adolescence, cytoskeletal dynamics, vulnerability genes, and behavioral traits impact long-term behavioral outcomes, complex decision-making, and disease vulnerability.

Publications

Action inflexibility and compulsive-like behavior accompany neurobiological alterations in the anterior orbitofrontal cortex and associated striatal nuclei.
Sci Rep Volume: 15 Page(s): 1863
01/13/2025 Authors: Butkovich LM; Yount ST; Allen AT; Seo EH; Swanson AM; Gourley SL
Social experience in adolescence shapes prefrontal cortex structure and function in adulthood.
Mol Psychiatry Volume: 29 Page(s): 2787 - 2798
09/01/2024 Authors: Li DC; Hinton EA; Guo J; Knight KA; Sequeira MK; Wynne ME; Dighe NM; Gourley SL
Cocaine disrupts action flexibility via glucocorticoid receptors.
iScience Volume: 27 Page(s): 110148
07/19/2024 Authors: Sequeira MK; Stachowicz KM; Seo EH; Yount ST; Gourley SL
A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit.
Prog Neurobiol Volume: 238 Page(s): 102632
07/01/2024 Authors: Yount ST; Wang S; Allen AT; Shapiro LP; Butkovich LM; Gourley SL
Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala.
Prog Neurobiol Volume: 238 Page(s): 102629
07/01/2024 Authors: Heaton EC; Seo EH; Butkovich LM; Yount ST; Gourley SL
Neuronal Ensembles in the Amygdala Allow Social Information to Motivate Later Decisions.
J Neurosci Volume: 44
04/17/2024 Authors: Kietzman HW; Trinoskey-Rice G; Seo EH; Guo J; Gourley SL
Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex.
Neurobiol Learn Mem Volume: 203 Page(s): 107789
09/01/2023 Authors: Davies RA; Barbee BR; Garcia-Sifuentes Y; Butkovich LM; Gourley SL
Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom.
Neurosci Biobehav Rev Volume: 150 Page(s): 105196
07/01/2023 Authors: Kalivas PW; Gourley SL; Paulus MP
Associations between nesting, stereotypy, and working memory in deer mice: response to levetiracetam.
Pharmacol Rep Volume: 75 Page(s): 647 - 656
06/01/2023 Authors: Hurter B; Gourley SL; Wolmarans DW
GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae.
Neuropsychopharmacology Volume: 48 Page(s): 1108 - 1117
06/01/2023 Authors: Li DC; Pitts EG; Dighe NM; Gourley SL
Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortex.
iScience Volume: 26 Page(s): 106240
04/21/2023 Authors: Sequeira MK; Swanson AM; Kietzman HW; Gourley SL
Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice.
PNAS Nexus Volume: 2 Page(s): pgad085
04/01/2023 Authors: Curtis MA; Dhamsania RK; Branco RC; Guo J-D; Creeden J; Neifer KL; Black CA; Winokur EJ; Andari E; Dias BG
How social information impacts action in rodents and humans: the role of the prefrontal cortex and its connections.
Neurosci Biobehav Rev Volume: 147 Page(s): 105075
04/01/2023 Authors: Kietzman HW; Gourley SL
Dysregulation of Prefrontal Oligodendrocyte Lineage Cells Across Mouse Models of Adversity and Human Major Depressive Disorder Oligodendrocyte dysregulation in mouse models of stress and MDD.
bioRxiv
03/10/2023 Authors: Sharma S; Ma W; Ressler KJ; Anderson T; Li DC; Jin P; Gourley SL; Qin Z
Medial orbitofrontal neurotrophin systems integrate hippocampal input into outcome-specific value representations.
Cell Rep Volume: 40 Page(s): 111334
09/13/2022 Authors: Woon EP; Butkovich LM; Peluso AA; Elbasheir A; Taylor K; Gourley SL
A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory.
Nat Neurosci Volume: 25 Page(s): 1213 - 1224
09/01/2022 Authors: Li DC; Dighe NM; Barbee BR; Pitts EG; Kochoian B; Blumenthal SA; Figueroa J; Leong T; Gourley SL
Social incentivization of instrumental choice in mice requires amygdala-prelimbic cortex-nucleus accumbens connectivity.
Nat Commun Volume: 13 Page(s): 4768
08/15/2022 Authors: Kietzman HW; Trinoskey-Rice G; Blumenthal SA; Guo JD; Gourley SL
Correction to: Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model.
Neuropsychopharmacology Volume: 47 Page(s): 1733
08/01/2022 Authors: Gross C; Banerjee A; Tiwari D; Longo F; White AR; Allen AG; Schroeder-Carter LM; Krzeski JC; Elsayed NA; Puckett R
LRcell: detecting the source of differential expression at the sub-cell-type level from bulk RNA-seq data.
Brief Bioinform Volume: 23
05/13/2022 Authors: Ma W; Sharma S; Jin P; Gourley SL; Qin ZS
Isoform-selective PI3-kinase Inhibition Confers Partial Resilience to Cocaine Cessation-induced Anxiety-like Behavior.
FASEB J Volume: 36 Suppl 1
05/01/2022 Authors: Barbee BR; Gourley SL
Cell adhesion presence during adolescence controls the architecture of projection-defined prefrontal cortical neurons and reward-related action strategies later in life.
Dev Cogn Neurosci Volume: 54 Page(s): 101097
04/01/2022 Authors: Kietzman HW; Shapiro LP; Trinoskey-Rice G; Gourley SL
Inter-individual variability amplified through breeding reveals control of reward-related action strategies by Melanocortin-4 Receptor in the dorsomedial striatum.
Commun Biol Volume: 5 Page(s): 116
02/08/2022 Authors: Allen AT; Heaton EC; Shapiro LP; Butkovich LM; Yount ST; Davies RA; Li DC; Swanson AM; Gourley SL
Pyk2 Stabilizes Striatal Medium Spiny Neuron Structure and Striatal-Dependent Action.
Cells Volume: 10
12/07/2021 Authors: Gourley SL; Srikanth KD; Woon EP; Gil-Henn H
Glucocorticoid Receptor Contributions to the Disruption of Action Selection by Cocaine
Volume: 46 Page(s): 408 - 408
12/01/2021 Authors: Sequeira M; Gourley S
An Integrated Amygdalo-Fronto-Striatal Network Governs Causal Learning and Memory
Volume: 46 Page(s): 429 - 429
12/01/2021 Authors: Li D; Dighe N; Barbee B; Pitts E; Kochoian B; Gourley S
Persistent behavioral and neurobiological consequences of social isolation during adolescence.
Semin Cell Dev Biol Volume: 118 Page(s): 73 - 82
10/01/2021 Authors: Li DC; Hinton EA; Gourley SL
A dubious distinction for females: rapid achievement of prefrontal cortical hypoactivity and cognitive deficit upon remifentanil self-administration.
Neuropsychopharmacology Volume: 46 Page(s): 1707 - 1708
09/01/2021 Authors: Gourley SL
Cell Adhesion Factors in the Orbitofrontal Cortex Control Cue-Induced Reinstatement of Cocaine Seeking and Amygdala-Dependent Goal Seeking.
J Neurosci Volume: 41 Page(s): 5923 - 5936
07/07/2021 Authors: Whyte AJ; Trinoskey-Rice G; Davies RA; Woon EP; Foster SL; Shapiro LP; Li DC; Srikanth KD; Gil-Henn H; Gourley SL
The PI3-Kinase p110 Isoform Controls Severity of Cocaine-Induced Sequelae and Alters the Striatal Transcriptome.
Biol Psychiatry Volume: 89 Page(s): 959 - 969
05/15/2021 Authors: Shapiro LP; Pitts EG; Li DC; Barbee BR; Hinton EA; Bassell GJ; Gross C; Gourley SL
Social Deprivation During Adolescence Disrupts GoalGuided Action and Prefrontal Cortical Neurobiology in Adulthood, Despite Social Reintegration
Volume: 89 Page(s): S52 - S52
05/01/2021 Authors: Li D; Gourley S
The stressed orbitofrontal cortex.
Behav Neurosci Volume: 135 Page(s): 202 - 209
04/01/2021 Authors: Sequeira MK; Gourley SL
Cocaine Elevates Calcium-Dependent Activator Protein for Secretion 2 in the Mouse Orbitofrontal Cortex.
Dev Neurosci Volume: 43 Page(s): 376 - 382
01/01/2021 Authors: Trinoskey-Rice GE; Woon EP; Pitts EG; Gourley SL
Cumulative Stress Burden on Motivated Action Revealed.
Biol Psychiatry Volume: 88 Page(s): 514 - 516
10/01/2020 Authors: Kietzman HW; Gourley SL
Reward-related dynamical coupling between basolateral amygdala and nucleus accumbens.
Brain Struct Funct Volume: 225 Page(s): 1873 - 1888
07/01/2020 Authors: Hsu C-C; Madsen TE; O'Gorman E; Gourley SL; Rainnie DG
Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal-directed action: A brief review.
J Neurosci Res Volume: 98 Page(s): 1020 - 1030
06/01/2020 Authors: Woon EP; Sequeira MK; Barbee BR; Gourley SL
Convergent Experimental Systems for Dissecting the Neurobiology of Intrusive Thought A Road Map
Page(s): 53 - 76
01/01/2020 Authors: Gourley SL; Bonci A; Bruchas MR; Flagel SB; Haber SN; Kalivas PW; Milton AL; Phillips PEM; Picciotto MR; Seamans JK
Morphological Responses of Excitatory Prelimbic and Orbitofrontal Cortical Neurons to Excess Corticosterone in Adolescence and Acute Stress in Adulthood.
Front Neuroanat Volume: 14 Page(s): 45
01/01/2020 Authors: Barfield ET; Sequeira MK; Parsons RG; Gourley SL
Linking actions with their consequences within the ventrolateral orbital cortex.
Neuropsychopharmacology Volume: 45 Page(s): 227 - 228
01/01/2020 Authors: Li DC; Gourley SL
Action-Outcome Expectancies Require Orbitofrontal Neurotrophin Systems in Nave and Cocaine-Exposed Mice.
Neurotherapeutics Volume: 17 Page(s): 165 - 177
01/01/2020 Authors: Pitts EG; Barfield ET; Woon EP; Gourley SL
Cell Adhesion Systems in the Orbitofrontal Cortex Confer Resilience to Cocaine
Volume: 44 Page(s): 10 - 11
12/01/2019 Authors: Gourley S
Glucocorticoid-sensitive ventral hippocampal-orbitofrontal cortical connections support goal-directed action - Curt Richter Award Paper 2019.
Psychoneuroendocrinology Volume: 110 Page(s): 104436
12/01/2019 Authors: Barfield ET; Gourley SL
1-Integrins in the Developing Orbitofrontal Cortex Are Necessary for Expectancy Updating in Mice.
J Neurosci Volume: 39 Page(s): 6644 - 6655
08/21/2019 Authors: DePoy LM; Shapiro LP; Kietzman HW; Roman KM; Gourley SL
Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex.
J Neurosci Volume: 39 Page(s): 4595 - 4605
06/05/2019 Authors: Whyte AJ; Kietzman HW; Swanson AM; Butkovich LM; Barbee BR; Bassell GJ; Gross C; Gourley SL
Anatomical specialties for value information.
Nat Neurosci Volume: 22 Page(s): 685 - 686
05/01/2019 Authors: Gourley SL
Corrigendum to "Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts" [Neurosci. Biobehav. Rev. 95 (2018) 535-558].
Neurosci Biobehav Rev Volume: 99 Page(s): 329
04/01/2019 Authors: Barfield ET; Gourley SL
Rho-kinase inhibition has antidepressant-like efficacy and expedites dendritic spine pruning in adolescent mice.
Neurobiol Dis Volume: 124 Page(s): 520 - 530
04/01/2019 Authors: Shapiro LP; Kietzman HW; Guo J; Rainnie DG; Gourley SL
Social Isolation in Adolescence Disrupts Cortical Development and Goal-Dependent Decision-Making in Adulthood, Despite Social Reintegration.
eNeuro Volume: 6
01/01/2019 Authors: Hinton EA; Li DC; Allen AG; Gourley SL
Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model.
Neuropsychopharmacology Volume: 44 Page(s): 324 - 333
01/01/2019 Authors: Gross C; Banerjee A; Tiwari D; Longo F; White AR; Allen AG; Schroeder-Carter LM; Krzeski JC; Elsayed NA; Puckett R
Social Adversity During Adolescence Weakens Goal-Directed Decision Making in Adulthood
Volume: 43 Page(s): S115 - S115
12/01/2018 Authors: Hinton E; Gourley S
Developmental Exposure to Pyrethroid Pesticide Causes an Autism-Related Phenotype and Dopamine System Alterations in Mice
Volume: 43 Page(s): S155 - S156
12/01/2018 Authors: Burkett J; Branco R; Dhamsania R; Winokur E; Gourley S; Miller G
Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts.
Neurosci Biobehav Rev Volume: 95 Page(s): 535 - 558
12/01/2018 Authors: Barfield ET; Gourley SL
Bidirectional coordination of actions and habits by TrkB in mice.
Sci Rep Volume: 8 Page(s): 4495
03/14/2018 Authors: Pitts EG; Li DC; Gourley SL
Memory Retention Involves the Ventrolateral Orbitofrontal Cortex: Comparison with the Basolateral Amygdala.
Neuropsychopharmacology Volume: 43 Page(s): 674
02/01/2018 Authors: Zimmermann KS; Li C-C; Rainnie DG; Ressler KJ; Gourley SL
Editorial: Long-Term Consequences of Adolescent Drug Use: Evidence From Pre-clinical and Clinical Models.
Front Behav Neurosci Volume: 12 Page(s): 83
01/01/2018 Authors: Whyte AJ; Torregrossa MM; Barker JM; Gourley SL
Memory Retention Involves the Ventrolateral Orbitofrontal Cortex: Comparison with the Basolateral Amygdala.
Neuropsychopharmacology Volume: 43 Page(s): 373 - 383
01/01/2018 Authors: Zimmermann KS; Li C-C; Rainnie DG; Ressler KJ; Gourley SL
Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase.
Mol Cell Neurosci Volume: 85 Page(s): 226 - 234
12/01/2017 Authors: Shapiro LP; Omar MH; Koleske AJ; Gourley SL
Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine.
Nat Commun Volume: 8 Page(s): 1861
11/30/2017 Authors: Swanson AM; DePoy LM; Gourley SL
Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure.
PLoS Biol Volume: 15 Page(s): e2003000
11/01/2017 Authors: Barfield ET; Gerber KJ; Zimmermann KS; Ressler KJ; Parsons RG; Gourley SL
Successful pharmacotherapy for the treatment of severe feeding aversion with mechanistic insights from cross-species neuronal remodeling.
Transl Psychiatry Volume: 7 Page(s): e1157
06/20/2017 Authors: Sharp WG; Allen AG; Stubbs KH; Criado KK; Sanders R; McCracken CE; Parsons RG; Scahill L; Gourley SL
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development.
J Neurosci Res Volume: 95 Page(s): 1123 - 1143
05/01/2017 Authors: Shapiro LP; Parsons RG; Koleske AJ; Gourley SL
The Rho-kinase inhibitor, fasudil, has antidepressant-like efficacy in adolescent mice
Volume: 31
04/01/2017 Authors: Shapiro L; Gourley S
Regulation of Goal-directed Action Selection by Cocaine, MDMA, and Orbitofrontal BDNF-trkB
Volume: 31
04/01/2017 Authors: Pitts E; Gourley S
Induction and Blockade of Adolescent Cocaine-Induced Habits.
Biol Psychiatry Volume: 81 Page(s): 595 - 605
04/01/2017 Authors: DePoy LM; Zimmermann KS; Marvar PJ; Gourley SL
Connections of the Mouse Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by Brain-Derived Neurotrophic Factor.
Biol Psychiatry Volume: 81 Page(s): 366 - 377
02/15/2017 Authors: Zimmermann KS; Yamin JA; Rainnie DG; Ressler KJ; Gourley SL
Adolescent Corticosterone and TrkB Pharmaco-Manipulations Sex-Dependently Impact Instrumental Reversal Learning Later in Life.
Front Behav Neurosci Volume: 11 Page(s): 237
01/01/2017 Authors: Barfield ET; Gourley SL
Adolescent cocaine self-administration induces habit behavior in adulthood: sex differences and structural consequences.
Transl Psychiatry Volume: 6 Page(s): e875
08/30/2016 Authors: DePoy LM; Allen AG; Gourley SL
Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors.
Neurobiol Dis Volume: 91 Page(s): 326 - 335
07/01/2016 Authors: Pitts EG; Taylor JR; Gourley SL
Mechanisms and Reversal of Adolescent Cocaine-Induced Habits
Volume: 79 Page(s): 303S - 304S
05/01/2016 Authors: DePoy LM; Gourley SL
The Antidepressant-like Utility of Rho-kinase Inhibition in Adolescents is TrkB -dependent
Volume: 79 Page(s): 409S - 409S
05/01/2016 Authors: Shapiro LP; Gourley SL
Regulation of Goal-directed Action Selection by Cocaine, MDMA, and Orbitofrontal BDNF-trkB
Volume: 79 Page(s): 408S - 409S
05/01/2016 Authors: Pitts EG; Garza K; Gourley S
TrkB Regulates Behavioral Vulnerabilities to Adolescent Stress Hormone Exposure
Volume: 79 Page(s): 198S - 198S
05/01/2016 Authors: Barfield ET; Gerber KJ; Zimmermann KS; Gourley SL
Reversal of the Durable Consequences of Adolescent Social Isolation
Volume: 79 Page(s): 198S - 198S
05/01/2016 Authors: Hinton EA; Allen AG; Gourley SL
Strain commonalities and differences in response-outcome decision making in mice.
Neurobiol Learn Mem Volume: 131 Page(s): 101 - 108
05/01/2016 Authors: Zimmermann KS; Hsu C-C; Gourley SL
Going and stopping: Dichotomies in behavioral control by the prefrontal cortex.
Nat Neurosci Volume: 19 Page(s): 656 - 664
04/26/2016 Authors: Gourley SL; Taylor JR
Going and stopping: dichotomies in behavioral control by the prefrontal cortex.
Nat Neurosci Volume: 19 Page(s): 656 - 664
04/26/2016 Authors: Gourley SL; Taylor JR
The Medial Orbitofrontal Cortex Regulates Sensitivity to Outcome Value.
J Neurosci Volume: 36 Page(s): 4600 - 4613
04/20/2016 Authors: Gourley SL; Zimmermann KS; Allen AG; Taylor JR
The Antidepressant-Like Utility of Rho-Kinase Inhibition in Adolescents is TrkB-Dependent
Volume: 40 Page(s): S337 - S337
12/01/2015 Authors: Shapiro L; Gourley S
Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure.
Traffic Volume: 16 Page(s): 919 - 940
09/01/2015 Authors: DePoy LM; Gourley SL
Adolescent-onset GABAA 1 silencing regulates reward-related decision making.
Eur J Neurosci Volume: 42 Page(s): 2114 - 2121
08/01/2015 Authors: Butkovich LM; DePoy LM; Allen AG; Shapiro LP; Swanson AM; Gourley SL
Voxel-based morphometry predicts shifts in dendritic spine density and morphology with auditory fear conditioning.
Nat Commun Volume: 6 Page(s): 7582
07/07/2015 Authors: Keifer OP; Hurt RC; Gutman DA; Keilholz SD; Gourley SL; Ressler KJ
Selective role of the catalytic PI3K subunit p110 in impaired higher order cognition in fragile X syndrome.
Cell Rep Volume: 11 Page(s): 681 - 688
05/05/2015 Authors: Gross C; Raj N; Molinaro G; Allen AG; Whyte AJ; Gibson JR; Huber KM; Gourley SL; Bassell GJ
The Orbitofrontal Cortex Regulates Behavioral Flexibility in Both Appetitive and Aversive Domains
Volume: 77 Page(s): 53S - 53S
05/01/2015 Authors: Zimmermann KS; Li C; Rainnie DG; Ressler KJ; Gourley SL
The ROCKII Inhibitor Fasudil Increases the Expression of Antidepressant-related Signaling Factors and has Antidepressant-like Efficacy in Adolescent Mice
Volume: 77 Page(s): 57S - 57S
05/01/2015 Authors: Shapiro LP; Gourley SL
GABAA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection.
Neuropsychopharmacology Volume: 40 Page(s): 1027 - 1036
03/01/2015 Authors: Swanson AM; Allen AG; Shapiro LP; Gourley SL
Adolescent Corticosteroid Exposure and TrkB Activity Regulate Action Selection and Depression-like Behavior in Adulthood
Volume: 39 Page(s): S319 - S320
12/01/2014 Authors: Gourley S
Orbitofrontal Cortical Regulation of Actions and Habits
Volume: 39 Page(s): S46 - S46
12/01/2014 Authors: Gourley S
Intersections of sex and corticotropin-releasing factor.
Biol Psychiatry Volume: 75 Page(s): 838 - 839
06/01/2014 Authors: Gourley SL; Taylor JR
Early-life cocaine interferes with BDNF-mediated behavioral plasticity.
Learn Mem Volume: 21 Page(s): 253 - 257
04/15/2014 Authors: Hinton EA; Wheeler MG; Gourley SL
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors.
Front Pharmacol Volume: 5 Page(s): 228
01/01/2014 Authors: DePoy LM; Perszyk RE; Zimmermann KS; Koleske AJ; Gourley SL
Glucocorticoid receptor regulation of action selection and prefrontal cortical dendritic spines.
Commun Integr Biol Volume: 6 Page(s): e26068
11/01/2013 Authors: Swanson AM; Shapiro LP; Whyte AJ; Gourley SL
The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum.
Eur J Neurosci Volume: 38 Page(s): 2382 - 2388
08/01/2013 Authors: Gourley SL; Olevska A; Zimmermann KS; Ressler KJ; Dileone RJ; Taylor JR
Cytoskeletal determinants of stimulus-response habits.
J Neurosci Volume: 33 Page(s): 11811 - 11816
07/17/2013 Authors: Gourley SL; Olevska A; Gordon J; Taylor JR
Bidirectional Modification of Response-Outcome Decision-Making Strategies by Cocaine and Rho-Kinase
Volume: 73 Page(s): 263S - 264S
05/01/2013 Authors: Swanson AM; Gourley SL
Developmentally divergent effects of Rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity.
Behav Brain Res Volume: 243 Page(s): 171 - 175
04/15/2013 Authors: DePoy LM; Noble B; Allen AG; Gourley SL
Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience.
J Neurosci Volume: 33 Page(s): 3107 - 3112
02/13/2013 Authors: Gourley SL; Swanson AM; Koleske AJ
Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents.
Psychopharmacology (Berl) Volume: 225 Page(s): 569 - 577
02/01/2013 Authors: Olausson P; Kiraly DD; Gourley SL; Taylor JR
Rho-kinase inhibition augments goal-directed decision-making and blocks habitual responding for cocaine
Volume: 24
01/01/2013 Authors: Swanson AM; DePoy LM; Gourley SL
Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning.
Transl Psychiatry Volume: 2 Page(s): e205
12/18/2012 Authors: Choi DC; Gourley SL; Ressler KJ
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding.
Proc Natl Acad Sci U S A Volume: 109 Page(s): 20714 - 20719
12/11/2012 Authors: Gourley SL; Swanson AM; Jacobs AM; Howell JL; Mo M; Dileone RJ; Koleske AJ; Taylor JR
Integrin 1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior.
J Neurosci Volume: 32 Page(s): 2824 - 2834
02/22/2012 Authors: Warren MS; Bradley WD; Gourley SL; Lin Y-C; Simpson MA; Reichardt LF; Greer CA; Taylor JR; Koleske AJ
Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction.
Biol Psychiatry Volume: 71 Page(s): 358 - 365
02/15/2012 Authors: Guarnieri DJ; Brayton CE; Richards SM; Maldonado-Aviles J; Trinko JR; Nelson J; Taylor JR; Gourley SL; DiLeone RJ
Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.
J Neurosci Volume: 32 Page(s): 2314 - 2323
02/15/2012 Authors: Gourley SL; Olevska A; Warren MS; Taylor JR; Koleske AJ
Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice.
Psychopharmacology (Berl) Volume: 219 Page(s): 805 - 814
02/01/2012 Authors: Gourley SL; Espitia JW; Sanacora G; Taylor JR
Cell adhesion signaling pathways: First responders to cocaine exposure?
Commun Integr Biol Volume: 4 Page(s): 30 - 33
01/01/2011 Authors: Gourley SL; Taylor JR; Koleske AJ
Dissociable regulation of instrumental action within mouse prefrontal cortex.
Eur J Neurosci Volume: 32 Page(s): 1726 - 1734
11/01/2010 Authors: Gourley SL; Lee AS; Howell JL; Pittenger C; Taylor JR
Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.
J Alzheimers Dis Volume: 20 Page(s): 1003 - 1008
01/01/2010 Authors: Couch BA; DeMarco GJ; Gourley SL; Koleske AJ
Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction.
Learn Mem Volume: 16 Page(s): 756 - 760
12/01/2009 Authors: Gourley SL; Howell JL; Rios M; DiLeone RJ; Taylor JR
Recapitulation and reversal of a persistent depression-like syndrome in rodents.
Curr Protoc Neurosci Volume: Chapter 9 Page(s): Unit - 9.32
10/01/2009 Authors: Gourley SL; Taylor JR
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine.
Proc Natl Acad Sci U S A Volume: 106 Page(s): 16859 - 16864
09/29/2009 Authors: Gourley SL; Koleske AJ; Taylor JR
A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF.
Neuropsychopharmacology Volume: 34 Page(s): 707 - 716
02/01/2009 Authors: Gourley SL; Kedves AT; Olausson P; Taylor JR
Corticosterone regulates pERK1/2 map kinase in a chronic depression model.
Ann N Y Acad Sci Volume: 1148 Page(s): 509 - 514
12/01/2008 Authors: Gourley SL; Wu FJ; Taylor JR
Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone.
Biol Psychiatry Volume: 64 Page(s): 884 - 890
11/15/2008 Authors: Gourley SL; Kiraly DD; Howell JL; Olausson P; Taylor JR
Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression.
Biol Psychiatry Volume: 63 Page(s): 353 - 359
02/15/2008 Authors: Gourley SL; Wu FJ; Kiraly DD; Ploski JE; Kedves AT; Duman RS; Taylor JR
Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.
J Neurosci Volume: 27 Page(s): 10982 - 10992
10/10/2007 Authors: Sfakianos MK; Eisman A; Gourley SL; Bradley WD; Scheetz AJ; Settleman J; Taylor JR; Greer CA; Williamson A; Koleske AJ
Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat.
Biol Psychiatry Volume: 62 Page(s): 496 - 504
09/01/2007 Authors: Banasr M; Valentine GW; Li X-Y; Gourley SL; Taylor JR; Duman RS
Modeling the persistent, depressive-like state in rodents: Long-lasting effects of prior chronic corticosterone
Volume: 59 Page(s): 6S - 6S
04/15/2006 Authors: Gourley SL; Kiraly DD; Taylor JR
Vulnerability factors in addiction: Prior chronic corticosterone induces a sensitized response to cocaine
Volume: 59 Page(s): 161S - 161S
04/15/2006 Authors: Quinn JJ; Gourley SL; Taylor JR
A Rho Inhibitory Pathway That Acts in Hippocampal Synapses to Regulate Dendrite Branch Stability
Volume: 17
01/01/2006 Authors: Sfakianos M; Eisman A; Gourley S; Taylor J; Greer CA; Williamson A; Koleske AJ
Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists.
Psychopharmacology (Berl) Volume: 178 Page(s): 232 - 240
03/01/2005 Authors: Gourley SL; Debold JF; Yin W; Cook J; Miczek KA
Anxiolytic-like effects of escitalopram in maternally separated and startled rodents: Comparison with citalopram and its R-enantiomer
Volume: 53 Page(s): 44S - 44S
04/15/2003 Authors: Miczek KA; Fish EW; Gourley S; Gupta S

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Shannon Gourley PhD

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