Sandra Garraway

Department of Cell Biology
Associate Professor

(404) 727-7417
smgarraway@emory.edu
Website

Academic Appointment

Assistant Professor, Emory University

Education

Degrees

PhD from University of Manitoba
B.Sc. from University of Guelph

Research

Focus

Maladaptive neuroplasticity after spinal cord injury often leads to impaired functional recovery and the development of chronic neuropathic pain. My research focuses on understanding the cellular/molecular mechanisms underlying maladaptive spinal plasticity. Studies utilizing behavioral, molecular and electrophysiological techniques will investigate neuronal/glial interactions and contributions made by concurrent peripheral noxious input.

Publications

Emergent epileptiform activity in spinal sensory circuits drives ectopic bursting in afferent axons and sensory dysfunction after cord injury.
Pain Volume: 166 Page(s): e27 - e35
02/01/2025 Authors: Bryson M; Kloefkorn H; Idlett-Ali S; Carrasco DI; Noble DJ; Martin K; Sawchuk MA; Au Yong N; Garraway SM; Hochman S
TrkB Agonist (7,8-DHF)-Induced Responses in Dorsal Root Ganglia Neurons Are Decreased after Spinal Cord Injury: Implication for Peripheral Pain Mechanisms.
eNeuro Volume: 12
01/01/2025 Authors: Jang K; Garraway SM
Diet-microbiome interactions promote enteric nervous system resilience following spinal cord injury.
NPJ Biofilms Microbiomes Volume: 10 Page(s): 75
08/29/2024 Authors: Hamilton AM; Blackmer-Raynolds L; Li Y; Kelly SD; Kebede N; Williams AE; Chang J; Garraway SM; Srinivasan S; Sampson TR
Diet-microbiome interactions promote enteric nervous system resilience following spinal cord injury.

06/08/2024 Authors: Hamilton AM; Blackmer-Raynolds L; Li Y; Kelly S; Kebede N; Williams A; Chang J; Garraway SM; Srinivasan S; Sampson TR
Sodium Bicarbonate Decreases Alcohol Consumption in Mice.
Int J Mol Sci Volume: 25
05/03/2024 Authors: Lin J; Rivadeneira AP; Ye Y; Ryu C; Parvin S; Jang K; Garraway SM; Choi I
A review of dorsal root ganglia and primary sensory neuron plasticity mediating inflammatory and chronic neuropathic pain.
Neurobiol Pain Volume: 15 Page(s): 100151
01/01/2024 Authors: Jang K; Garraway SM
Emergent epileptiform activity drives spinal sensory circuits to generate ectopic bursting in intraspinal afferent axons after cord injury.
bioRxiv
07/12/2023 Authors: Bryson M; Kloefkorn H; Idlett-Ali S; Martin K; Garraway SM; Hochman S
Atrial Natriuretic Peptide and the Epithelial Sodium Channel Contribute to Spinal Cord Injury-Induced Polyuria in Mice.
J Neurotrauma Volume: 39 Page(s): 724 - 734
05/01/2022 Authors: Sun X-S; Wang X-L; Bai M; Song C; Eaton DC; Yue Q; Martin KK; Cai H; Garraway S; Wang L-H
C-low threshold mechanoreceptor activation becomes sufficient to trigger affective pain in spinal cord-injured mice in association with increased respiratory rates.
Front Integr Neurosci Volume: 16 Page(s): 1081172
01/01/2022 Authors: Noble DJ; Dongmo R; Parvin S; Martin KK; Garraway SM
Pharmacogenetic inhibition of TrkB signaling in adult mice attenuates mechanical hypersensitivity and improves locomotor function after spinal cord injury.
Front Cell Neurosci Volume: 16 Page(s): 987236
01/01/2022 Authors: Martin KK; Noble DJ; Parvin S; Jang K; Garraway SM
Spinal Cord Injury Increases Pro-inflammatory Cytokine Expression in Kidney at Acute and Sub-chronic Stages.
Inflammation Volume: 44 Page(s): 2346 - 2361
12/01/2021 Authors: Parvin S; Williams CR; Jarrett SA; Garraway SM
Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model.
Neuropsychopharmacology Volume: 46 Page(s): 2011 - 2020
10/01/2021 Authors: Wong JC; Grieco SF; Dutt K; Chen L; Thelin JT; Inglis GAS; Parvin S; Garraway SM; Xu X; Goldin AL
MICROBIOME ALTERATIONS LEAD TO IMPAIRED GASTROINTESTINAL MOTILITY FOLLOWING SPINAL CORD INJURY
Volume: 160 Page(s): S735 - S735
05/01/2021 Authors: Hamilton AM; Chang J; Garraway SM; Srinivasan S; Sampson TR
Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.
Behav Brain Res Volume: 401 Page(s): 113065
03/05/2021 Authors: Choi I; Beedholm K; Dam VS; Bae S-H; Noble DJ; Garraway SM; Aalkjaer C; Boedtkjer E
Spontaneous and Stimulus-Evoked Respiratory Rate Elevation Corresponds to Development of Allodynia in Spinal Cord-Injured Rats.
J Neurotrauma Volume: 36 Page(s): 1909 - 1922
06/15/2019 Authors: Noble DJ; Martin KK; Parvin S; Garraway SM
Peripheral Inflammation Accelerates the Onset of Mechanical Hypersensitivity after Spinal Cord Injury and Engages Tumor Necrosis Factor Signaling Mechanisms.
J Neurotrauma Volume: 36 Page(s): 2000 - 2010
06/15/2019 Authors: Martin KK; Parvin S; Garraway SM
Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death.
Front Syst Neurosci Volume: 12 Page(s): 27
01/01/2018 Authors: Turtle JD; Strain MM; Reynolds JA; Huang Y-J; Lee KH; Henwood MK; Garraway SM; Grau JW
When Pain Hurts: Nociceptive Stimulation Induces a State of Maladaptive Plasticity and Impairs Recovery after Spinal Cord Injury.
J Neurotrauma Volume: 34 Page(s): 1873 - 1890
05/15/2017 Authors: Grau JW; Huang Y-J; Turtle JD; Strain MM; Miranda RC; Garraway SM; Hook MA
Neurobiological Effects of Morphine after Spinal Cord Injury.
J Neurotrauma Volume: 34 Page(s): 632 - 644
02/01/2017 Authors: Hook MA; Woller SA; Bancroft E; Aceves M; Funk MK; Hartman J; Garraway SM
Slow Breathing Can Be Operantly Conditioned in the Rat and May Reduce Sensitivity to Experimental Stressors.
Front Physiol Volume: 8 Page(s): 854
01/01/2017 Authors: Noble DJ; Goolsby WN; Garraway SM; Martin KK; Hochman S
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Exp Neurol Volume: 285 Page(s): 82 - 95
11/01/2016 Authors: Huang Y-J; Lee KH; Murphy L; Garraway SM; Grau JW
Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in Uninjured and Injured Spinal Cord.
Neural Plast Volume: 2016 Page(s): 9857201
01/01/2016 Authors: Garraway SM; Huie JR
NOCICEPTIVE STIMULATION INDUCES CASPASE 1 ACTIVATION FOLLOWING SPINAL CORD INJURY
Volume: 32 Page(s): A91 - A91
06/15/2015 Authors: Turtle J; Strain M; Reynolds J; Huang Y-J; Garraway S; Grau J
Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis.
Pain Volume: 155 Page(s): 2344 - 2359
11/01/2014 Authors: Garraway SM; Woller SA; Huie JR; Hartman JJ; Hook MA; Miranda RC; Huang Y-J; Ferguson AR; Grau JW
Organization of sensory input to the nociceptive-specific cutaneous trunk muscle reflex in rat, an effective experimental system for examining nociception and plasticity.
J Comp Neurol Volume: 522 Page(s): 1048 - 1071
04/01/2014 Authors: Petruska JC; Barker DF; Garraway SM; Trainer R; Fransen JW; Seidman PA; Soto RG; Mendell LM; Johnson RD
Regulatory effects of intermittent noxious stimulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion.
Front Neural Circuits Volume: 8 Page(s): 117
01/01/2014 Authors: Strickland ER; Woller SA; Garraway SM; Hook MA; Grau JW; Miranda RC
Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury.
Front Neural Circuits Volume: 8 Page(s): 100
01/01/2014 Authors: Grau JW; Huie JR; Lee KH; Hoy KC; Huang Y-J; Turtle JD; Strain MM; Baumbauer KM; Miranda RM; Hook MA
Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation.
Neuroscience Volume: 200 Page(s): 74 - 90
01/03/2012 Authors: Huie JR; Garraway SM; Baumbauer KM; Hoy KC; Beas BS; Montgomery KS; Bizon JL; Grau JW
Impact of behavioral control on the processing of nociceptive stimulation.
Front Physiol Volume: 3 Page(s): 262
01/01/2012 Authors: Grau JW; Huie JR; Garraway SM; Hook MA; Crown ED; Baumbauer KM; Lee KH; Hoy KC; Ferguson AR
Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury.
Front Physiol Volume: 3 Page(s): 399
01/01/2012 Authors: Ferguson AR; Huie JR; Crown ED; Baumbauer KM; Hook MA; Garraway SM; Lee KH; Hoy KC; Grau JW
Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats.
Neuroscience Volume: 199 Page(s): 86 - 102
12/29/2011 Authors: Garraway SM; Turtle JD; Huie JR; Lee KH; Hook MA; Woller SA; Grau JW
Cav1.2 L-type Ca channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.
J Neurosci Volume: 31 Page(s): 13562 - 13575
09/21/2011 Authors: Schierberl K; Hao J; Tropea TF; Ra S; Giordano TP; Xu Q; Garraway SM; Hofmann F; Moosmang S; Striessnig J
siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats.
J Pain Volume: 10 Page(s): 380 - 390
04/01/2009 Authors: Garraway SM; Xu Q; Inturrisi CE
Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity.
J Neurosci Volume: 28 Page(s): 14087 - 14096
12/24/2008 Authors: Xu Q; Garraway SM; Weyerbacher AR; Shin SJ; Inturrisi CE
Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn.
J Pharmacol Exp Ther Volume: 322 Page(s): 982 - 988
09/01/2007 Authors: Garraway SM; Xu Q; Inturrisi CE
Spinal cord transection enhances afferent-evoked inhibition in lamina II neurons and abolishes BDNF-induced facilitation of their sensory input.
J Neurotrauma Volume: 24 Page(s): 379 - 390
02/01/2007 Authors: Garraway SM; Mendell LM
BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injury.
J Neurophysiol Volume: 94 Page(s): 1798 - 1804
09/01/2005 Authors: Garraway SM; Anderson AJ; Mendell LM
Spatial and temporal gene expression profiling of the contused rat spinal cord.
Exp Neurol Volume: 189 Page(s): 204 - 221
10/01/2004 Authors: Aimone JB; Leasure JL; Perreau VM; Thallmair M; Christopher Reeve Paralysis Foundation Research Consortium
BDNF sensitizes the response of lamina II neurons to high threshold primary afferent inputs.
Eur J Neurosci Volume: 18 Page(s): 2467 - 2476
11/01/2003 Authors: Garraway SM; Petruska JC; Mendell LM
Serotonin 5-HT(2) receptor activation induces a long-lasting amplification of spinal reflex actions in the rat.
J Physiol Volume: 537 Page(s): 201 - 207
11/15/2001 Authors: Machacek DW; Garraway SM; Shay BL; Hochman S
Modulatory actions of serotonin, norepinephrine, dopamine, and acetylcholine in spinal cord deep dorsal horn neurons.
J Neurophysiol Volume: 86 Page(s): 2183 - 2194
11/01/2001 Authors: Garraway SM; Hochman S
Serotonin increases the incidence of primary afferent-evoked long-term depression in rat deep dorsal horn neurons.
J Neurophysiol Volume: 85 Page(s): 1864 - 1872
05/01/2001 Authors: Garraway SM; Hochman S
Pharmacological characterization of serotonin receptor subtypes modulating primary afferent input to deep dorsal horn neurons in the neonatal rat.
Br J Pharmacol Volume: 132 Page(s): 1789 - 1798
04/01/2001 Authors: Garraway SM; Hochman S
Membrane properties of deep dorsal horn neurons from neonatal rat spinal cord in vitro.
Brain Res Volume: 767 Page(s): 214 - 219
09/05/1997 Authors: Hochman S; Garraway SM; Pockett S
Primary afferent-evoked synaptic plasticity in deep dorsal horn neurons from neonatal rat spinal cord in vitro.
Neurosci Lett Volume: 230 Page(s): 61 - 64
07/11/1997 Authors: Garraway SM; Pockett S; Hochman S

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Sandra Garraway

Academic Appointment

Education

Degrees

Research

Focus

Publications