Publications

• Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas.
  Nat Commun Volume: 16 Page(s): 4114
  05/02/2025 Authors: Mumme HL; Huang C; Ohlstrom D; Bakhtiari M; Raikar SS; DeRyckere D; Qayed M; Castellino SM; Wechsler DS; Porter CC
• Single-Cell Analysis of Debrided Diabetic Foot Ulcers Reveals Dysregulated Wound Healing Environment in Non-Hispanic Black Patients.
  J Invest Dermatol Volume: 145 Page(s): 678 - 690
  03/01/2025 Authors: Choi D; Bakhtiari M; Pilcher W; Huang C; Thomas BE; Mumme H; Blanco G; Rajani R; Schechter MC; Fayfman M
• MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity.
  Leukemia Volume: 38 Page(s): 2685 - 2698
  12/01/2024 Authors: Huelse JM; Bhasin SS; Jacobsen KM; Yim J; Thomas BE; Branella GM; Bakhtiari M; Chimenti ML; Baxter TA; Raikar SS
• Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics.
  Circ Res Volume: 135 Page(s): 110 - 134
  06/21/2024 Authors: Michaud ME; Mota L; Bakhtiari M; Thomas BE; Tomeo J; Pilcher W; Contreras M; Ferran C; Bhasin SS; Pradhan-Nabzdyk L
• A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma.
  bioRxiv
  05/17/2024 Authors: Pilcher WC; Yao L; Gonzalez-Kozlova E; Pita-Juarez Y; Karagkouni D; Acharya CR; Michaud ME; Hamilton M; Nanda S; Song Y
• Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells.
  J Virol Volume: 98 Page(s): e0019424
  05/14/2024 Authors: Moore KM; Pelletier A-N; Lapp S; Metz A; Tharp GK; Lee M; Bhasin SS; Bhasin M; Skaly R-P; Bosinger SE
• Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantation.
  bioRxiv
  03/02/2024 Authors: Michaud ME; Mota L; Bakhtiari M; Thomas BE; Tomeo J; Pilcher W; Contreras M; Ferran C; Bhasin S; Pradhan-Nabzdyk L
• Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells.
  
  01/21/2024 Authors: Moore KM; Pelletier A-N; Lapp S; Metz A; Tharp GK; Lee M; Bhasin SS; Bhasin M; Skaly R-P; Bosinger SE
• ARMH1 is a novel marker associated with poor pediatric AML outcomes that affect the fatty acid synthesis and cell cycle pathways.
  Front Oncol Volume: 14 Page(s): 1445173
  01/01/2024 Authors: Bakhtiari M; Jordan SC; Mumme HL; Sharma R; Shanmugam M; Bhasin SS; Bhasin M
• Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia.
  Genome Med Volume: 15 Page(s): 83
  10/16/2023 Authors: Mumme HL; Raikar SS; Bhasin SS; Thomas BE; Lawrence T; Weinzierl EP; Pang Y; DeRyckere D; Gawad C; Wechsler DS
• Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia.
  Nat Commun Volume: 14 Page(s): 6209
  10/05/2023 Authors: Mumme H; Thomas BE; Bhasin SS; Krishnan U; Dwivedi B; Perumalla P; Sarkar D; Ulukaya GB; Sabnis HS; Park SI
• Single-cell profiling reveals inflammaging-associated dysregulations in rapidly progressing multiple myeloma patients
  Volume: 23 Page(s): S263 - S264
  09/01/2023 Authors: Pilcher W; Yao L; Kozlova EG; Pita-Juarez Y; Karagkouni D; Ma Y; Thomas B; Satpathy S; Bhasin S; Song Y
• Taxane chemotherapy induces stromal injury that leads to breast cancer dormancy escape.
  PLoS Biol Volume: 21 Page(s): e3002275
  09/01/2023 Authors: Ganesan R; Bhasin SS; Bakhtiary M; Krishnan U; Cheemarla NR; Thomas BE; Bhasin MK; Sukhatme VP
• Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis.
  Sci Rep Volume: 13 Page(s): 12556
  08/02/2023 Authors: Bhasin SS; Thomas BE; Summers RJ; Sarkar D; Mumme H; Pilcher W; Emam M; Raikar SS; Park SI; Castellino SM
• The 'omics of obesity in B-cell acute lymphoblastic leukemia.
  J Natl Cancer Inst Monogr Volume: 2023 Page(s): 12 - 29
  05/04/2023 Authors: Geitgey DK; Lee M; Cottrill KA; Jaffe M; Pilcher W; Bhasin S; Randall J; Ross AJ; Salemi M; Castillo-Castrejon M
• Targeting a positive feedback loop of MERTK and STAT3 during macrophage differentiation may provide anti-tumor immune function
  Volume: 83
  04/01/2023 Authors: Yan D; Huelse JM; Bhasin SS; Bhasin M; DeRyckere D; Graham DK
• Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma.
  NPJ Genom Med Volume: 8 Page(s): 3
  01/26/2023 Authors: Pilcher W; Thomas BE; Bhasin SS; Jayasinghe RG; Yao L; Gonzalez-Kozlova E; Dasari S; Kim-Schulze S; Rahman A; Patton J
• The Simple prEservatioN of Single cElls method for cryopreservation enables the generation of single-cell immune profiles from whole blood.
  Front Immunol Volume: 14 Page(s): 1271800
  01/01/2023 Authors: Satpathy S; Thomas BE; Pilcher WJ; Bakhtiari M; Ponder LA; Pacholczyk R; Prahalad S; Bhasin SS; Munn DH; Bhasin MK
• Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis.
  Cancer Res Commun Volume: 2 Page(s): 1255 - 1265
  10/01/2022 Authors: Yao L; Jayasinghe RG; Lee BH; Bhasin SS; Pilcher W; Doxie DB; Gonzalez-Kozlova E; Dasari S; Fiala MA; Pita-Juarez Y
• Survival Genie, a web platform for survival analysis across pediatric and adult cancers.
  Sci Rep Volume: 12 Page(s): 3069
  02/23/2022 Authors: Dwivedi B; Mumme H; Satpathy S; Bhasin SS; Bhasin M
• Single cell transcriptomic landscape of diabetic foot ulcers.
  Nat Commun Volume: 13 Page(s): 181
  01/10/2022 Authors: Theocharidis G; Thomas BE; Sarkar D; Mumme HL; Pilcher WJR; Dwivedi B; Sandoval-Schaefer T; Srbulescu RF; Kafanas A; Mezghani I
• A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies.
  Haematologica Volume: 106 Page(s): 2759 - 2762
  10/01/2021 Authors: Vandorpe DH; Shmukler BE; Ilboudo Y; Bhasin S; Thomas B; Rivera A; Wohlgemuth JG; Dlott JS; Snyder LM; Sieff C
• Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model.
  Haematologica Volume: 106 Page(s): 1330 - 1342
  05/01/2021 Authors: Stroopinsky D; Liegel J; Bhasin M; Cheloni G; Thomas B; Bhasin S; Panchal R; Ghiasuddin H; Rahimian M; Nahas M
• Single Cell Transcriptomics Revealed AML and Non-AML Cell Clusters Relevant to Relapse and Remission in Pediatric AML
  Volume: 136
  11/05/2020 Authors: Thomas BE; Perumalla P; Bhasin SS; Sarkar D; Dwivedi B; Park SI; DeRyckere D; Henry CJ; Raikar SS; Porter CC
• Identification and Validation of CD138-Multiple Myeloma Immune and Tumor Subpopulations Using Cross Center Scrna-Seq Data
  Volume: 136
  11/05/2020 Authors: Jayasinghe RG; Yao L; Thomas B; Bhasin SS; Fernandez N; Avigan DE; Kourelis T; Dhodapkar MV; Vij R; Mehr S
• Characterization of Plasma and Immune Cells Molecular Landscape That Play a Role in Rapid Progression of Multiple Myeloma Using Cross Center Scrna-Seq Study
  Volume: 136
  11/05/2020 Authors: Bhasin M; Thomas BE; Jayasinghe RG; Fernandez N; Bhasin SS; Kourelis T; Dhodapkar MV; Vij R; Kumar SK; Mehr S
• Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers.
  Diabetes Volume: 69 Page(s): 2157 - 2169
  10/01/2020 Authors: Theocharidis G; Baltzis D; Roustit M; Tellechea A; Dangwal S; Khetani RS; Shu B; Zhao W; Fu J; Bhasin S
• TFEB-driven lysosomal biogenesis is pivotal for PGC1-dependent renal stress resistance.
  JCI Insight Volume: 5
  08/06/2020 Authors: Lynch MR; Tran MT; Ralto KM; Zsengeller ZK; Raman V; Bhasin SS; Sun N; Chen X; Brown D; Rovira II
• Topical Application of a Mast Cell Stabilizer Improves Impaired Diabetic Wound Healing.
  J Invest Dermatol Volume: 140 Page(s): 901 - 911.e11
  04/01/2020 Authors: Tellechea A; Bai S; Dangwal S; Theocharidis G; Nagai M; Koerner S; Cheong JE; Bhasin S; Shih T-Y; Zheng Y
• Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists.
  Sci Adv Volume: 6 Page(s): eaay8230
  01/01/2020 Authors: Chen J; Haller CA; Jernigan FE; Koerner SK; Wong DJ; Wang Y; Cheong JE; Kosaraju R; Kwan J; Park DD
• Biological and behavioral markers of pain following nerve injury in humans.
  Neurobiol Pain Volume: 7 Page(s): 100038
  01/01/2020 Authors: Holmes SA; Barakat N; Bhasin M; Lopez NI; Lebel A; Zurakowski D; Thomas B; Bhasin S; Silva KE; Borra R
• Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.
  J Clin Invest Volume: 129 Page(s): 2964 - 2979
  06/17/2019 Authors: Panigrahy D; Gartung A; Yang J; Yang H; Gilligan MM; Sulciner ML; Bhasin SS; Bielenberg DR; Chang J; Schmidt BA
• TFEB-driven lysosomal biogenesis is pivotal for PGC1-dependent renal stress resistance.
  JCI Insight Volume: 5
  03/14/2019 Authors: Lynch MR; Tran MT; Ralto KM; Zsengeller ZK; Raman V; Bhasin SS; Sun N; Chen X; Brown D; Rovira II
• Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.
  Oncogenesis Volume: 8 Page(s): 15
  02/22/2019 Authors: Chen C-H; Bhasin S; Khanna P; Joshi M; Joslin PM; Saxena R; Amin S; Liu S; Sindhu S; Walker SR
• Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin.
  FASEB J Volume: 33 Page(s): 114 - 125
  01/01/2019 Authors: Chang J; Bhasin SS; Bielenberg DR; Sukhatme VP; Bhasin M; Huang S; Kieran MW; Panigrahy D
• Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGF1 Axis.
  Clin Cancer Res Volume: 24 Page(s): 6078 - 6097
  12/01/2018 Authors: Prete A; Lo AS; Sadow PM; Bhasin SS; Antonello ZA; Vodopivec DM; Ullas S; Sims JN; Clohessy J; Dvorak AM
• Downregulation of Dipeptidyl Peptidase 4 Accelerates Progression to Castration-Resistant Prostate Cancer.
  Cancer Res Volume: 78 Page(s): 6354 - 6362
  11/15/2018 Authors: Russo JW; Gao C; Bhasin SS; Voznesensky OS; Calagua C; Arai S; Nelson PS; Montgomery B; Mostaghel EA; Corey E
• Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C: Targeting fibronectin type III repeats of tenascin-C in rheumatoid arthritis.
  Int Immunopharmacol Volume: 58 Page(s): 15 - 23
  05/01/2018 Authors: Mehta BB; Tiwari A; Sharma S; Shukla A; Sharma M; Vasishta RK; Sen RK; Sharma A; Luthra-Guptasarma M
• Blocking osteopontin-fibronectin interactions reduce extracellular fibronectin deployment and arthritic immunopathology.
  Int Immunopharmacol Volume: 55 Page(s): 297 - 305
  02/01/2018 Authors: Mehta BB; Sharma S; Vasishta RK; Sen RK; Sharma A; Luthra-Guptasarma M
• Single Cell Rna-seq Analyses of Healthy Skin and Diabetic Ulcers Reveals Fundamentally Different Cell Type-specific Transcriptional Profiles
  Volume: 26 Page(s): A3 - A4
  01/01/2018 Authors: Theocharidis G; Bhasin S; Kounas K; Thanh D; Rosenblum B; Bhasin M; Veves A
• A systems-level "misunderstanding": the plasma metabolome in Huntington's disease.
  Ann Clin Transl Neurol Volume: 2 Page(s): 756 - 768
  07/01/2015 Authors: Rosas HD; Doros G; Bhasin S; Thomas B; Gevorkian S; Malarick K; Matson W; Hersch SM
• Structures of differently aggregated and precipitated forms of gamma B crystallin: an FTIR spectroscopic and EM study.
  Protein Pept Lett Volume: 17 Page(s): 1155 - 1162
  09/01/2010 Authors: Fatima U; Sharma S; Guptasarma P
• Replacement of the active surface of a thermophile protein by that of a homologous mesophile protein through structure-guided 'protein surface grafting'.
  Biochim Biophys Acta Volume: 1784 Page(s): 1771 - 1776
  11/01/2008 Authors: Kapoor D; Kumar V; Chandrayan SK; Ahmed S; Sharma S; Datt M; Singh B; Karthikeyan S; Guptasarma P
• Dimorphic aggregation behavior of a fusion polypeptide incorporating a stable protein domain (EGFP) with an amyloidogenic sequence (retroCspA).
  FEBS Lett Volume: 582 Page(s): 2203 - 2211
  06/25/2008 Authors: Sharma S; Guptasarma P
• Evidence of native-like substructure(s) in polypeptide chains of carbonic anhydrase deposited into insoluble aggregates during thermal unfolding.
  Protein J Volume: 27 Page(s): 50 - 58
  01/01/2008 Authors: Sharma S; Guptasarma P
• Identification and characterization of a spontaneously aggregating amyloid-forming variant of human PrP((90-231)) through phage-display screening of variants randomized between residues 101 and 112.
  Int J Biochem Cell Biol Volume: 40 Page(s): 663 - 676
  01/01/2008 Authors: Verma A; Sharma S; Ganguly NK; Majumdar S; Guptasarma P; Luthra-Guptasarma M
• Confocal spectrofluorimetric evidence for the hetero-aggregation of sequence-scrambled forms of two model all-beta sheet proteins.
  Int J Biol Macromol Volume: 41 Page(s): 650 - 654
  12/01/2007 Authors: Shukla A; Sharma S; Guptasarma P
• Putative structure and characteristics of a red water-soluble pigment secreted by Penicillium marneffei.
  Med Mycol Volume: 45 Page(s): 419 - 427
  08/01/2007 Authors: Bhardwaj S; Shukla A; Mukherjee S; Sharma S; Guptasarma P; Chakraborti AK; Chakrabarti A
• Dihydrotestosterone-induced conformational perturbations in androgen receptor: Kinetic and thermodynamic insights.
  Volume: 54 Page(s): S96 - S96
  01/01/2006 Authors: Jasuja R; Miksovska J; Bhasin M; Ganley J; Chandsawangbhuwana S; Baker M; Larsen RW; Bhasin S
• Slow irreversible unfolding of Pyrococcus furiosus triosephosphate isomerase: separation and quantitation of conformers through a novel electrophoretic approach.
  Anal Biochem Volume: 347 Page(s): 49 - 59
  12/01/2005 Authors: Mukherjee S; Sharma S; Kumar S; Guptasarma P
• A novel UV laser-induced visible blue radiation from protein crystals and aggregates: scattering artifacts or fluorescence transitions of peptide electrons delocalized through hydrogen bonding?
  Arch Biochem Biophys Volume: 428 Page(s): 144 - 153
  08/15/2004 Authors: Shukla A; Mukherjee S; Sharma S; Agrawal V; Radha Kishan KV; Guptasarma P
• Androstenedione binds to androgen receptor and promotes myogenic differentiation: Is it an anabolic steroid?
  Volume: 52 Page(s): S98 - S98
  01/01/2004 Authors: Jasuja R; Pandurangan R; Artaza J; Bhasin M; Bhasin S