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Profile

Svetlana Atasheva PhD

  • Department of Pediatrics
    Assistant Professor
  • (404) 727-2990
  • svetlana.atasheva@emory.edu
Head shot of Svetlana Atasheva

Research

Publications

  • Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells invivo using the engineered AVID adenovirus vector platform.
    Mol Ther Volume: 32 Page(s): 3743 - 3745
    10/02/2024 Authors: Yao J; Atasheva S; Wagner N; Di Paolo NC; Stewart PL; Shayakhmetov DM
  • Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells in vivo using the engineered AVID adenovirus vector platform.
    Mol Ther Volume: 32 Page(s): 103 - 123
    01/03/2024 Authors: Yao J; Atasheva S; Wagner N; Di Paolo NC; Stewart PL; Shayakhmetov DM
  • p38MAPK guards the integrity of endosomal compartments through regulating necrotic death.
    Sci Rep Volume: 12 Page(s): 16357
    09/29/2022 Authors: Yao J; Atasheva S; Toy R; Blanchard EL; Santangelo PJ; Roy K; Mocarski ES; Shayakhmetov DM
  • Cytokine Responses to Adenovirus and Adenovirus Vectors.
    Viruses Volume: 14
    04/24/2022 Authors: Atasheva S; Shayakhmetov DM
  • Oncolytic Viruses for Systemic Administration: Engineering a Whole Different Animal.
    Mol Ther Volume: 29 Page(s): 904 - 907
    03/03/2021 Authors: Atasheva S; Shayakhmetov DM
  • Systemic cancer therapy with engineered adenovirus that evades innate immunity.
    Sci Transl Med Volume: 12
    11/25/2020 Authors: Atasheva S; Emerson CC; Yao J; Young C; Stewart PL; Shayakhmetov DM
  • Cellular dynamics of productive anti-tumor response mediating long-term rejection of disseminated lung tumors after systemic therapy with oncolytic adenovirus
    Volume: 80
    08/01/2020 Authors: Yao J; Atasheva S; Young CB; Shayakhmetov DM
  • Tumor-targeted oncolytic adenovirus demonstrates high cytotoxicity for human lung and renal cell carcinomas independently of the level of tumor PD-L1 expression.
    Volume: 38
    05/20/2020 Authors: Yao J; Atasheva S; Young C; Master VA; Shayakhmetov D
  • Cellular Innate Immune Mechanisms Mediating Long-Term Rejection of Disseminated Lung Tumors after Systemic Therapy with Oncolytic Adenovirus
    Volume: 28 Page(s): 156 - 156
    04/28/2020 Authors: Yao J; Atasheva S; Young C; Shayakhmetov D
  • Single-Cell Transcriptomics Analysis of a Complete Response Phenotype in Mice with Disseminated Lung Cancer after Systemic Therapy with Oncolytic Adenovirus
    Volume: 28 Page(s): 591 - 591
    04/28/2020 Authors: Atasheva S; Yao J; Young C; Shayakhmetov D
  • Innate immunity to adenovirus: lessons from mice.
    FEBS Lett Volume: 593 Page(s): 3461 - 3483
    12/01/2019 Authors: Atasheva S; Yao J; Shayakhmetov DM
  • Preclinical assessment of efficacy and safety of novel oncolytic adenovirus for therapy of disseminated lung cancer
    Volume: 79
    07/01/2019 Authors: Atasheva S; Yao J; Young C; Di Paolo NC; Wyche H; Shayakhmetov DM
  • Development of an Oncolytic Adenovirus for Systemic Intravascular Administration for Treatment of Solid and Disseminated Tumors in Mouse Lung Adenocarcinoma Model
    Volume: 27 Page(s): 123 - 124
    04/22/2019 Authors: Atasheva S; Emerson C; Young C; Stewart P; Shayakhmetov D
  • Pre-Clinical Assessment of Efficacy and Safety of Novel Oncolytic Adenovirus for Therapy of Disseminated Lung Cancer
    Volume: 27 Page(s): 121 - 122
    04/22/2019 Authors: Atasheva S; Yao J; Young C; Di Paolo N; Wyche H; Shayakhmetov D
  • Molecular Determinants Limiting Productive Replication of Human Adenovirus in Mouse Cells
    Volume: 25 Page(s): 266 - 266
    05/01/2017 Authors: Atasheva S; Shayakhmetov D
  • Adenovirus sensing by the immune system.
    Curr Opin Virol Volume: 21 Page(s): 109 - 113
    12/01/2016 Authors: Atasheva S; Shayakhmetov DM
  • Functional Role of Adenovirus Penton in Modulating In Vivo Properties of Liver-Targeted and Liver-Detargeted Adenovirus Variants
    Volume: 24 Page(s): S7 - S7
    05/01/2016 Authors: Atasheva S; Emerson C; Di Paolo NC; Irons E; Gulati N; Stewart P; Shayakhmetov DM
  • Adenovirus Variant With a Defined Set of Genetic Mutations in the Penton and Hexon Escapes Liver Sequestration After Intravascular Administration
    Volume: 23 Page(s): S20 - S20
    05/01/2015 Authors: Atasheva S; Di Paolo N; Doronin K; Shayakhmetov D
  • IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.
    PLoS Pathog Volume: 11 Page(s): e1004863
    04/01/2015 Authors: Reynaud JM; Kim DY; Atasheva S; Rasalouskaya A; White JP; Diamond MS; Weaver SC; Frolova EI; Frolov I
  • Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.
    J Virol Volume: 89 Page(s): 71 - 82
    01/01/2015 Authors: Atasheva S; Kim DY; Frolova EI; Frolov I
  • Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 10708 - 10713
    07/22/2014 Authors: Kim DY; Atasheva S; McAuley AJ; Plante JA; Frolova EI; Beasley DWC; Frolov I
  • Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication.
    J Virol Volume: 88 Page(s): 2116 - 2130
    02/01/2014 Authors: Atasheva S; Frolova EI; Frolov I
  • Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.
    J Virol Volume: 87 Page(s): 4202 - 4213
    04/01/2013 Authors: Kim DY; Atasheva S; Frolova EI; Frolov I
  • Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation.
    J Virol Volume: 87 Page(s): 2023 - 2035
    02/01/2013 Authors: Atasheva S; Kim DY; Akhrymuk M; Morgan DG; Frolova EI; Frolov I
  • Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes.
    J Virol Volume: 87 Page(s): 1997 - 2010
    02/01/2013 Authors: Foy NJ; Akhrymuk M; Akhrymuk I; Atasheva S; Bopda-Waffo A; Frolov I; Frolova EI
  • New PARP gene with an anti-alphavirus function.
    J Virol Volume: 86 Page(s): 8147 - 8160
    08/01/2012 Authors: Atasheva S; Akhrymuk M; Frolova EI; Frolov I
  • Early events in alphavirus replication determine the outcome of infection.
    J Virol Volume: 86 Page(s): 5055 - 5066
    05/01/2012 Authors: Frolov I; Akhrymuk M; Akhrymuk I; Atasheva S; Frolova EI
  • Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution.
    J Virol Volume: 85 Page(s): 8022 - 8036
    08/01/2011 Authors: Kim DY; Firth AE; Atasheva S; Frolova EI; Frolov I
  • Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.
    J Virol Volume: 85 Page(s): 4363 - 4376
    05/01/2011 Authors: Kim DY; Atasheva S; Foy NJ; Wang E; Frolova EI; Weaver S; Frolov I
  • Functional Sindbis virus replicative complexes are formed at the plasma membrane.
    J Virol Volume: 84 Page(s): 11679 - 11695
    11/01/2010 Authors: Frolova EI; Gorchakov R; Pereboeva L; Atasheva S; Frolov I
  • Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein.
    J Virol Volume: 84 Page(s): 10004 - 10015
    10/01/2010 Authors: Atasheva S; Krendelchtchikova V; Liopo A; Frolova E; Frolov I
  • Venezuelan equine Encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.
    J Virol Volume: 84 Page(s): 4158 - 4171
    05/01/2010 Authors: Atasheva S; Fish A; Fornerod M; Frolova EI
  • Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription.
    J Virol Volume: 83 Page(s): 9031 - 9044
    09/01/2009 Authors: Frolov I; Garmashova N; Atasheva S; Frolova EI
  • Structural and functional elements of the promoter encoded by the 5' untranslated region of the Venezuelan equine encephalitis virus genome.
    J Virol Volume: 83 Page(s): 8327 - 8339
    09/01/2009 Authors: Kulasegaran-Shylini R; Atasheva S; Gorenstein DG; Frolov I
  • Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus.
    Vaccine Volume: 27 Page(s): 4309 - 4319
    07/09/2009 Authors: Atasheva S; Wang E; Adams AP; Plante KS; Ni S; Taylor K; Miller ME; Frolov I; Weaver SC
  • A new role for ns polyprotein cleavage in Sindbis virus replication.
    J Virol Volume: 82 Page(s): 6218 - 6231
    07/01/2008 Authors: Gorchakov R; Frolova E; Sawicki S; Atasheva S; Sawicki D; Frolov I
  • Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in Mammalian but not in mosquito cells.
    J Virol Volume: 82 Page(s): 4028 - 4041
    04/01/2008 Authors: Atasheva S; Garmashova N; Frolov I; Frolova E
  • Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription.
    J Virol Volume: 81 Page(s): 13552 - 13565
    12/01/2007 Authors: Garmashova N; Atasheva S; Kang W; Weaver SC; Frolova E; Frolov I
  • Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells.
    Virology Volume: 362 Page(s): 475 - 487
    06/05/2007 Authors: Michel G; Petrakova O; Atasheva S; Frolov I
  • Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning.
    J Virol Volume: 81 Page(s): 5046 - 5057
    05/01/2007 Authors: Atasheva S; Gorchakov R; English R; Frolov I; Frolova E
  • Formation of nsP3-specific protein complexes during Sindbis virus replication.
    J Virol Volume: 80 Page(s): 4122 - 4134
    04/01/2006 Authors: Frolova E; Gorchakov R; Garmashova N; Atasheva S; Vergara LA; Frolov I
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