Publications

• Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague-dawley rat.
  Geroscience Volume: 47 Page(s): 3007 - 3026
  06/01/2025 Authors: Nist KM; Bard H; McBride B; Capriglione AL; Moreira JD; Farb DH; Wainford RD
• Pharmacokinetics and Pharmacodynamics of neffy, Epinephrine Nasal Spray, in Pediatric Allergy Patients.
  J Allergy Clin Immunol Pract Volume: 13 Page(s): 1335 - 1341.e1
  06/01/2025 Authors: Fleischer DM; Li HH; Talreja N; Lockey RF; Kaliner MA; Wainford RD; Greenhawt MJ; Casale TB; Lowenthal R; Tanimoto S
• Proposed mechanism of cardiovascular responses for bolus injection of epinephrine from epinephrine autoinjectors.
  J Allergy Clin Immunol Pract Volume: 13 Page(s): 944 - 946.e1
  04/01/2025 Authors: Kaliner MA; Wainford RD; Ebisawa M; Casale TB; Lieberman J; Lowenthal R; Tanimoto S
• Integrated renal and sympathetic mechanisms underlying the development of sex- and age-dependent hypertension and the salt sensitivity of blood pressure.
  Geroscience Volume: 46 Page(s): 6435 - 6458
  12/01/2024 Authors: Frame AA; Nist KM; Kim K; Puleo F; Moreira JD; Swaldi H; McKenna J; Wainford RD
• Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague Dawley rats.
  Physiol Genomics
  11/16/2024 Authors: Amraei R; Lampl N; Nist KM; Zhang Y; Wainford RD
• Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats.
  Am J Physiol Renal Physiol Volume: 327 Page(s): F277 - F289
  08/01/2024 Authors: Kim K; Nist KM; Puleo F; McKenna J; Wainford RD
• Renal denervation restores biomechanics of carotid arteries in a rat model of hypertension.
  Sci Rep Volume: 14 Page(s): 495
  01/04/2024 Authors: Gkousioudi A; Razzoli M; Moreira JD; Wainford RD; Zhang Y
• Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension.
  J Hypertens Volume: 42 Page(s): 23 - 49
  01/01/2024 Authors: Charchar FJ; Prestes PR; Mills C; Ching SM; Neupane D; Marques FZ; Sharman JE; Vogt L; Burrell LM; Korostovtseva L
• Compromised homeostasis in aged carotid arteries revealed by microstructural studies of elastic lamellae.
  J Mech Behav Biomed Mater Volume: 148 Page(s): 106187
  12/01/2023 Authors: Gkousioudi A; Sigaeva T; Yu X; Seta F; Wainford RD; Zhang Y
• Renal denervation restores biomechanics of carotid arteries in a rat model of hypertension.
  Res Sq
  09/05/2023 Authors: Gkousioudi A; Razzoli M; Moreira JD; Wainford RD; Zhang Y
• 2022 World Hypertension League, Resolve To Save Lives and International Society of Hypertension dietary sodium (salt) global call to action.
  J Hum Hypertens Volume: 37 Page(s): 428 - 437
  06/01/2023 Authors: Campbell NRC; Whelton PK; Orias M; Wainford RD; Cappuccio FP; Ide N; Neal B; Cohn J; Cobb LK; Webster J
• Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension.
  Cardiovasc Res Volume: 119 Page(s): 381 - 409
  03/31/2023 Authors: Schutte AE; Jafar TH; Poulter NR; Damasceno A; Khan NA; Nilsson PM; Alsaid J; Neupane D; Kario K; Beheiry H
• SYMPATHETIC REGULATION OF SALT SENSITIVITY
  Volume: 41 Page(s): E112 - E112
  01/01/2023 Authors: Wainford R
• Renin-Angiotensin System Inhibitors in Patients With COVID-19: A Meta-Analysis of Randomized Controlled Trials Led by the International Society of Hypertension.
  J Am Heart Assoc Volume: 11 Page(s): e026143
  09/06/2022 Authors: Gnanenthiran SR; Borghi C; Burger D; Caramelli B; Charchar F; Chirinos JA; Cohen JB; Cremer A; Di Tanna GL; Duvignaud A
• Age-Dependent Hypertension-Related Cognitive Impairment And Neuroinflammation In Sprague Dawley Rats Can Be Reversed By An AT1R Antagonism
  Volume: 79
  09/01/2022 Authors: Nist KM; Wainford RD
• Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging.
  Front Bioeng Biotechnol Volume: 10 Page(s): 862996
  01/01/2022 Authors: Gkousioudi A; Yu X; Ferruzzi J; Qian J; Wainford RD; Seta F; Zhang Y
• Central Gi2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity.
  Front Endocrinol (Lausanne) Volume: 13 Page(s): 895466
  01/01/2022 Authors: Amraei R; Moreira JD; Wainford RD
• Renin-Angiotensin System Inhibitors in Patients With Covid-19: A Prospective Meta-analysis of Randomised Controlled Trials Led by the International Society of Hypertension
  Volume: 144 Page(s): E577 - E578
  12/21/2021 Authors: Gnanenthiran S; Borghi C; Burger DE; Caramelli B; Chirinos JA; Cohen J; Cremer A; Di Tanna GL; Freilich D; Gracia-Ramos A
• The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging.
  Behav Neurosci Volume: 135 Page(s): 680 - 692
  10/01/2021 Authors: Farris CW; Killiany RJ; O'Donoghue E; Koo B-B; Wainford RD; Moss MB; Rosene DL; Moore TL
• An exploratory analysis of comparative plasma metabolomic and lipidomic profiling in salt-sensitive and salt-resistant individuals from The Dietary Approaches to Stop Hypertension Sodium Trial.
  J Hypertens Volume: 39 Page(s): 1972 - 1981
  10/01/2021 Authors: Chaudhary P; Velkoska E; Wainford RD
• Vascular Remodeling And Impaired Vascular Smooth Muscle Cell Plasticity In Age And Sex-dependent Hypertension
  Volume: 78
  09/01/2021 Authors: Amraei R; Nist K; Moreira J; Wainford RD
• AT1R-Dependent Blood-Brain Barrier Disruption Precedes Neuroinflammation In Age-Dependent Hypertension
  Volume: 78
  09/01/2021 Authors: Nist KM; Moreira J; Wainford RD
• Association of urinary sodium and potassium excretion with systolic blood pressure in the Dietary Approaches to Stop Hypertension Sodium Trial.
  J Hum Hypertens Volume: 35 Page(s): 577 - 587
  07/01/2021 Authors: Chaudhary P; Wainford RD
• Prospective meta-analysis protocol on randomised trials of renin-angiotensin system inhibitors in patients with COVID-19: an initiative of the International Society of Hypertension.
  BMJ Open Volume: 11 Page(s): e043625
  02/16/2021 Authors: Gnanenthiran SR; Borghi C; Burger D; Charchar F; Poulter NR; Schlaich MP; Steckelings UM; Stergiou G; Tomaszewski M; Unger T
• Natriuresis During an Acute Intravenous Sodium Chloride Infusion in Conscious Sprague Dawley Rats Is Mediated by a Blood Pressure-Independent 1-Adrenoceptor-Mediated Mechanism.
  Front Physiol Volume: 12 Page(s): 784957
  01/01/2021 Authors: Frame AA; Nist KM; Kim K; Kuwabara JT; Wainford RD
• Sensory Afferent Renal Nerve Activated Gi2 Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges.
  Front Physiol Volume: 12 Page(s): 771167
  01/01/2021 Authors: Moreira JD; Nist KM; Carmichael CY; Kuwabara JT; Wainford RD
• Neuroanatomical characterization of Gi2-expressing neurons in the hypothalamic paraventricular nucleus of male and female Sprague-Dawley rats.
  Physiol Genomics Volume: 53 Page(s): 12 - 21
  01/01/2021 Authors: Chaudhary P; Wainford RD
• Sympathetic Regulation of the NCC (Sodium Chloride Cotransporter) in Dahl Salt-Sensitive Hypertension.
  Hypertension Volume: 76 Page(s): 1461 - 1469
  11/01/2020 Authors: Puleo F; Kim K; Frame AA; Walsh KR; Ferdaus MZ; Moreira JD; Comsti E; Faudoa E; Nist KM; Abkin E
• Pvn-specific Microgliosis And Inflammation Precedes Sympathoexcitation In g[alpha]I2Protein-dependent, Salt-sensitive Hypertension.
  Volume: 76
  09/01/2020 Authors: Moreira JD; Chaudhary P; Nist KM; Wainford RD
• May Measurement Month 2018: results of blood pressure screening from 41 countries.
  Eur Heart J Suppl Volume: 22 Page(s): H1 - H4
  08/01/2020 Authors: Poulter NR; Borghi C; Burger D; Castillo RR; Damasceno A; Ito S; Jose AP; Kruger R; Morgan T; Nilsson PM
• May Measurement Month 2019: The Global Blood Pressure Screening Campaign of the International Society of Hypertension.
  Hypertension Volume: 76 Page(s): 333 - 341
  08/01/2020 Authors: Beaney T; Schutte AE; Stergiou GS; Borghi C; Burger D; Charchar F; Cro S; Diaz A; Damasceno A; Espeche W
• 2020 International Society of Hypertension Global Hypertension Practice Guidelines.
  Hypertension Volume: 75 Page(s): 1334 - 1357
  06/01/2020 Authors: Unger T; Borghi C; Charchar F; Khan NA; Poulter NR; Prabhakaran D; Ramirez A; Schlaich M; Stergiou GS; Tomaszewski M
• 2020 International Society of Hypertension global hypertension practice guidelines.
  J Hypertens Volume: 38 Page(s): 982 - 1004
  06/01/2020 Authors: Unger T; Borghi C; Charchar F; Khan NA; Poulter NR; Prabhakaran D; Ramirez A; Schlaich M; Stergiou GS; Tomaszewski M
• Highlights from the International Society of Hypertension's New Investigators Network during 2019.
  J Hypertens Volume: 38 Page(s): 968 - 973
  05/01/2020 Authors: Kruger R; Brunstrm M; Burger D; Charchar F; Climie R; Mirabito Colafella KM; Kempny P; Korostovtseva L; Marques FZ; Picone D
• Hypothalamic Paraventricular Nucleus Gi2 (Guanine Nucleotide-Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein-Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure.
  Hypertension Volume: 75 Page(s): 1002 - 1011
  04/01/2020 Authors: Carmichael CY; Kuwabara JT; Pascale CL; Moreira JD; Mahne SE; Kapusta DR; Rosene DL; Williams JS; Cunningham JT; Wainford RD
• Neuroinflammation and Age-Dependent Salt-Sensitive Hypertension
  Volume: 34
  04/01/2020 Authors: Nist K; Wainford R
• Impaired NCC Activity and Regulation on Dietary High Dietary Salt Intake in Aged Sprague Dawley Rats Is Associated with Increased Salt Sensitivity of Blood Pressure
  Volume: 34
  04/01/2020 Authors: Kim K; Puleo F; Frame A; Wainford R
• Anatomical Characterization Of G alpha i(2) Expressing Hypothalamic Paraventricular Nucleus Neurons
  Volume: 34
  04/01/2020 Authors: Chaudhary P; Wainford R
• Microglial-Mediated PVN Inflammation Precedes Sympathoexcitation but not Hypertension in the Development of Gai(2) Protein-Dependent Salt Sensitive Hypertension
  Volume: 34
  04/01/2020 Authors: Moreira J; Chaudhary P; Nist K; Wainford R
• Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gi2 protein-dependent, salt-sensitive hypertension.
  Exp Physiol Volume: 104 Page(s): 1892 - 1910
  12/01/2019 Authors: Moreira JD; Chaudhary P; Frame AA; Puleo F; Nist KM; Abkin EA; Moore TL; George JC; Wainford RD
• Sympathetic regulation of NCC in norepinephrine-evoked salt-sensitive hypertension in Sprague-Dawley rats.
  Am J Physiol Renal Physiol Volume: 317 Page(s): F1623 - F1636
  12/01/2019 Authors: Frame AA; Puleo F; Kim K; Walsh KR; Faudoa E; Hoover RS; Wainford RD
• May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension (vol 40, pg 2006, 2019)
  EUROPEAN HEART JOURNAL Volume: 40 Page(s): 3109 - 3109
  10/01/2019 Authors: Beaney T; Burrell LM; Castillo RR; Charchar FJ; Cro S; Damasceno A; Kruger R; Nilsson PM; Prabhakaran D; Ramirez AJ
• Increased Urinary Potassium Excretion Does Not Associate With Reduced Systolic Blood Pressure in the Dietary Approaches to Stop Hypertension Sodium Trial
  Volume: 74
  09/01/2019 Authors: Chaudhary P; Wainford RD
• Pvn-Specific Microgliosis Drives Inflammation in G-Alpha-i(2) Protein Dependent Salt Sensitive Hypertension and Gnai2 Snps Correlate With Essential Hypertension
  Volume: 74
  09/01/2019 Authors: Moreira JD; Chaudhary P; Nist KM; Abkin E; Frame AA; Puleo F; Wainford RD
• Sex Differences in the Development of Age-Dependent Hypertension and the Salt Sensitivity of Blood Pressure
  Volume: 74
  09/01/2019 Authors: Puleo FJ; Frame AA; Chaudhary P; Wainford RD
• Role of the afferent renal nerves in sodium homeostasis and blood pressure regulation in rats.
  Exp Physiol Volume: 104 Page(s): 1306 - 1323
  08/01/2019 Authors: Frame AA; Carmichael CY; Kuwabara JT; Cunningham JT; Wainford RD
• May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension.
  Eur Heart J Volume: 40 Page(s): 2006 - 2017
  07/01/2019 Authors: Beaney T; Burrell LM; Castillo RR; Charchar FJ; Cro S; Damasceno A; Kruger R; Nilsson PM; Prabhakaran D; Ramirez AJ
• May Measurement Month 2017: Results of 39 national blood pressure screening programmes.
  Eur Heart J Suppl Volume: 21 Page(s): D1 - D4
  04/01/2019 Authors: Poulter NR; Borghi C; Castillo RR; Charchar FJ; Ramirez AJ; Schlaich MP; Schutte AE; Stergiou G; Unger T; Wainford RD
• A selective impairment in the mechanosensitive afferent renal nerve-mediated sympathoinhibitory reno-renal reflex contributes to age-related hypertension
  Volume: 33
  04/01/2019 Authors: Frame AA; Puleo FJ; Faudoa E; Moreira JD; Wainford RD
• alpha 1-Adrenoceptor Antagonism Attenuates the Development and Progression of Dahl Salt Sensitive Rat Hypertension by Modulating NCC Activity
  Volume: 33
  04/01/2019 Authors: Puleo F; Frame AA; Moreira JD; Faudoa E; Wainford RD
• Moving the Needle on Hypertension: What Knowledge Is Needed?
  Volume: 54 Page(s): 248 - 256
  01/01/2019 Authors: Frame AA; Farquhar WB; Latulippe ME; McDonough AA; Wainford RD; Wynne BM
• GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study.
  Physiol Genomics Volume: 50 Page(s): 724 - 725
  09/01/2018 Authors: Zhang X; Frame AA; Williams JS; Wainford RD
• PVN Inflammation Contributes to Brain G[alpha]I2 Protein Dependent Sympathetically Mediated Salt Sensitive Hypertension
  Volume: 72
  09/01/2018 Authors: Wainford RD; George J
• Renal and Neural Mechanisms of Age-Related Hypertension
  Volume: 72
  09/01/2018 Authors: Frame AA; Wainford RD
• May Measurement Month 2017: an analysis of blood pressure screening results worldwide.
  Lancet Glob Health Volume: 6 Page(s): e736 - e743
  07/01/2018 Authors: Beaney T; Schutte AE; Tomaszewski M; Ariti C; Burrell LM; Castillo RR; Charchar FJ; Damasceno A; Kruger R; Lackland DT
• Mechanisms of altered renal sodium handling in age-related hypertension.
  Am J Physiol Renal Physiol Volume: 315 Page(s): F1 - F6
  07/01/2018 Authors: Frame AA; Wainford RD
• How to Reduce Dietary Salt Intake: Just Add Spice?
  Hypertension Volume: 70 Page(s): 1087 - 1088
  12/01/2017 Authors: Wainford RD
• Sympathetically Alpha-1 Adrenoceptor Mediated Regulation of the NCC in Rat Models of Salt Sensitive and Neurogenic Hypertension.
  Volume: 70
  09/01/2017 Authors: Wainford RD; Frame AA
• PVN Galphai2 Protein Over Expression Attenuates Dahl Salt Sensitive Hypertension and GNAI2 Polymorphic Variance Represents a Clinical Biomarker of the Salt Sensitivity of Blood Pressure.
  Volume: 70
  09/01/2017 Authors: Wainford RD; Zhang X
• Sympathetic and Renal Mechanisms of Age-related Hypertension
  Volume: 70
  09/01/2017 Authors: Wainford RD; Frame AA
• Renal sodium handling and sodium sensitivity.
  Kidney Res Clin Pract Volume: 36 Page(s): 117 - 131
  06/01/2017 Authors: Frame AA; Wainford RD
• Hypertension and Sodium Homeostasis in Aging: Impaired Natriuretic Responses to Alterations in Fluid and Electrolyte Balance Accompany Hypertension in Aged Sprague-Dawley Rats
  Volume: 31
  04/01/2017 Authors: Frame AA; Desai AN; Hai JD; Wainford RD
• Impaired Hypothalamic PVN G-alpha i(2) Signal Transduction Attenuates Endogenous Sympathoinhibitory PVN GABAergic Tone to Evoke the Development of Salt-sensitive Hypertension
  Volume: 68
  09/01/2016 Authors: Wainford RD; Shim J
• Renal Afferents.
  Curr Hypertens Rep Volume: 18 Page(s): 69
  09/01/2016 Authors: Frame AA; Carmichael CY; Wainford RD
• Impaired Central, Renal, and Blood Pressure Responses to Alterations in Fluid and Electrolyte Homeostasis in Aged Sprague-Dawley Rats
  Volume: 68
  09/01/2016 Authors: Frame AA; Rodrigues KR; Whelan LM; Wainford RD
• Sympathetically Mediated Alpha-1 Adrenoceptor Regulation of the NCC During High Salt Intake: A New Therapeutic Target for Resistant Hypertension
  Volume: 68
  09/01/2016 Authors: Wainford RD; Walsh KR
• Afferent Renal Nerve Chemo- and Mechanosensitive Responses and the Modulation of Sodium Homeostasis and Blood Pressure
  Volume: 68
  09/01/2016 Authors: Frame AA; Carmichael CY; Walsh KR; Wainford RD
• Cross-talk Between Dietary Salt Intake And Norepinephrine In The Regulation Of Renal NCC Activity And Blood Pressure
  Volume: 30
  04/01/2016 Authors: Wainford RD; Ruan QT; Walsh KR
• The role of G alpha i(2) proteins in the regulation of PVN neuronal activation in response to isotonic volume expansion in conscious rats
  Volume: 30
  04/01/2016 Authors: Carmichael CY; Patel NM; Wipfler RE; Wainford RD
• Renal Afferent Nerve Modulation Of Sodium Homeostasis And Blood Pressure: A Sodium Sensitive Mechanism Countering The Development Of Salt-Sensitive Hypertension?
  Volume: 30
  04/01/2016 Authors: Wainford RD; Walsh KR; Carmichael CY
• Roles Of Central alpha(2) And AT1 Signal Transduction Via Gai(2) Proteins In Blood Pressure Regulation In Response To An Acute Sodium Challenge
  Volume: 30
  04/01/2016 Authors: Shim JW; Wainford RD; Carmichael CY
• Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Gi2 proteins.
  Acta Physiol (Oxf) Volume: 216 Page(s): 314 - 329
  03/01/2016 Authors: Carmichael CY; Carmichael ACT; Kuwabara JT; Cunningham JT; Wainford RD
• Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats.
  Am J Physiol Regul Integr Comp Physiol Volume: 310 Page(s): R115 - R124
  01/15/2016 Authors: Walsh KR; Kuwabara JT; Shim JW; Wainford RD
• Correction: Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.
  Clin Sci (Lond) Volume: 129 Page(s): 673
  10/01/2015 Authors: Brouwers S; Smolders I; Wainford RD; Dupont AG
• Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.
  Clin Sci (Lond) Volume: 129 Page(s): 81 - 92
  07/01/2015 Authors: Brouwers S; Smolders I; Wainford RD; Dupont AG
• NIGHTTIME HYPOTENSIVE EFFECTS OF CENTRAL ANGIOTENSIN II TYPE 2 RECEPTOR STIMULATION THROUGH IMPROVED SPONTANEOUS BAROREFLEX SENSITIVITY: MORE IN SHR THAN IN WKY
  Volume: 33 Page(s): E116 - E116
  06/01/2015 Authors: Brouwers S; Wainford RD; Smolders I; Dupont AG
• Impact of global versus renal-specific sympathoinhibition in aldosterone-induced hypertension: implications for medical device-based treatment of resistant hypertension.
  Hypertension Volume: 65 Page(s): 1160 - 1162
  06/01/2015 Authors: Carmichael CY; Wainford RD
• Hypothalamic signaling mechanisms in hypertension.
  Curr Hypertens Rep Volume: 17 Page(s): 39
  05/01/2015 Authors: Carmichael CY; Wainford RD
• Across the globe in 4 months: two International Society of Hypertension new investigator symposia in 2014.
  J Hypertens Volume: 33 Page(s): 891 - 893
  04/01/2015 Authors: Veerabhadrappa P; Burger D; Brouwers S; Christofidou P; Bikai REL; Hannah-Shmouni F; Kruger R; Marques FZ; Rehman Mian MO; Montezano AC
• The renal afferent nerves: A role in countering salt-sensitive hypertension?
  Volume: 29
  04/01/2015 Authors: Carmichael C; Su S; Wainford R
• A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin.
  Am J Physiol Regul Integr Comp Physiol Volume: 308 Page(s): R112 - R122
  01/15/2015 Authors: Foss JD; Wainford RD; Engeland WC; Fink GD; Osborn JW
• Brain Gi 2 -subunit proteins and the prevention of salt sensitive hypertension.
  Front Physiol Volume: 6 Page(s): 233
  01/01/2015 Authors: Carmichael CY; Wainford RD
• Gi2-protein-mediated signal transduction: central nervous system molecular mechanism countering the development of sodium-dependent hypertension.
  Hypertension Volume: 65 Page(s): 178 - 186
  01/01/2015 Authors: Wainford RD; Carmichael CY; Pascale CL; Kuwabara JT
• Impaired PVN Neuronal Activity In Rats Lacking Central G alpha i2 Proteins: Implications For The Pathophysiology Of Salt-Sensitive Hypertension
  Volume: 64
  09/01/2014 Authors: Carmichael CY; Carmichael AC; Vartanyan P; Wainford RD
• Animal Models of Salt-Sensitive Hypertension Show Impaired Renal Sodium Chloride Cotransporter (NCC) Function
  Volume: 64
  09/01/2014 Authors: Walsh KR; Wainford RD
• Activation of Central Angiotensin II type 2 Receptors Attenuates Neurogenic Hypertension
  Volume: 64
  09/01/2014 Authors: Brouwers S; Wainford RD; Smolders I; Dupont AG
• Presympathetic neuron dysfunction--time to reconsider increased intrinsic activity as the cause of neurogenic hypertension.
  Exp Physiol Volume: 99 Page(s): 935 - 936
  07/01/2014 Authors: Wainford RD
• Angiotensin AT2 receptors and the baroreflex control of renal sympathetic nerve activity.
  Acta Physiol (Oxf) Volume: 210 Page(s): 714 - 716
  04/01/2014 Authors: Wainford RD
• Brain Gai2 Proteins Mediate Acute Neural Blood Pressure Responses to Centrally and Peripherally Administered NaCl
  Volume: 62
  09/01/2013 Authors: Carmichael CY; Mahne S; Wainford RD
• PVN GaI2 Subunit Proteins - The Key to a Salt-resistant Phenotype?
  Volume: 62
  09/01/2013 Authors: Wainford RD; Kuwabara JT
• Norepinephrine Evoked Salt-Sensitive Hypertension Results in Impaired NCC Function, but Not Expression
  Volume: 62
  09/01/2013 Authors: Walsh K; Mahne S; Kuwabara JT; Wainford RD
• A role for Gai(2) proteins in the acute neural control of blood pressure.
  Volume: 27
  04/01/2013 Authors: Carmichael CY; Wainford RD
• A genetically based GPCR-mediated central molecular mechanism underlying the pathophysiology of salt-sensitive hypertension
  Volume: 27
  04/01/2013 Authors: Wainford RD; Carmichael CY; Kuwabara JT
• Brain Gi2-subunit protein-gated pathways are required to mediate the centrally evoked sympathoinhibitory mechanisms activated to maintain sodium homeostasis.
  J Hypertens Volume: 31 Page(s): 747 - 757
  04/01/2013 Authors: Wainford RD; Pascale CL; Kuwabara JT
• Central nervous system Gi2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway.
  Hypertension Volume: 61 Page(s): 368 - 375
  02/01/2013 Authors: Kapusta DR; Pascale CL; Kuwabara JT; Wainford RD
• Brain heterotrimeric Gi-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress.
  FASEB J Volume: 26 Page(s): 2776 - 2787
  07/01/2012 Authors: Kapusta DR; Pascale CL; Wainford RD
• Functional selectivity of central G-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central (2) -adrenoceptor activation in vivo.
  Br J Pharmacol Volume: 166 Page(s): 210 - 220
  05/01/2012 Authors: Wainford RD; Kapusta DR
• The GNAI2 gene - a candidate biomarker of hypertension that determines salt-resistance vs. salt-sensitivity in rat models
  Volume: 26
  04/01/2012 Authors: Wainford RD; Kapusta DR
• CNS G alpha i(2)subunit proteins - the origin of impaired fluid and electrolyte homeostasis and blood pressure regulation in a salt-sensitive phenotype?
  Volume: 26
  04/01/2012 Authors: Wainford RD; Pascale CL
• Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus.
  Endocrinology Volume: 153 Page(s): 1411 - 1420
  03/01/2012 Authors: Yoshida T; Semprun-Prieto L; Wainford RD; Sukhanov S; Kapusta DR; Delafontaine P
• ANGIOTENSIN II REDUCES FOOD INTAKE BY ALTERING OREXIGENIC NEUROPEPTIDE EXPRESSION IN THE MOUSE HYPOTHALAMUS
  Volume: 60 Page(s): 338 - 338
  01/01/2012 Authors: Yoshida T; Semprun-Prieto L; Wainford RD; Sukhanov S; Kapusta DR; Delafontaine P
• PVN G alpha i(2)-subunit Proteins Play a Critical Role in the Central Neural Mechanisms Maintaining Fluid and Electrolyte Homeostasis in Sprague-Dawley Rats Following Dietary Sodium Challenge
  Volume: 58 Page(s): E99 - E99
  11/01/2011 Authors: Pascale CL; Wainford RD
• A novel CNS G alpha i(2) protein-gated renal sympathoinhibitory mechanism is activated in salt-resistant subjects to prevent salt-sensitive hypertension
  Volume: 25
  04/01/2011 Authors: Wainford RD; Kapusta DR
• A novel CNS G alpha i(2) protein-gated renal sympathoinhibitory pathway is essential to maintain sodium and water homeostasis in response to isovolumetric sodium loading
  Volume: 25
  04/01/2011 Authors: Wainford RD
• Brain G alpha z/G alpha q subunit protein-gated pathways participate in regulating AVP secretion and urine output during conditions in which water homeostasis is challenged
  Volume: 25
  04/01/2011 Authors: Kapusta DR; Wainford RD; Ewing JE
• Endogenous CNS G alpha i(2) Proteins Mediate the Central Neural Sympathoinhibitory Responses Activated in Salt-Resistant Subjects to Prevent the Development of Salt-Sensitive Hypertension
  Volume: 56 Page(s): E71 - E71
  11/01/2010 Authors: Wainford RD; Kapusta DR
• Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats.
  Endocrinology Volume: 151 Page(s): 5403 - 5414
  11/01/2010 Authors: Wainford RD; Kapusta DR
• CNS G alpha i(2) proteins participate in the central neural regulation of sodium and water homeostasis and in countering salt-sensitive hypertension
  Volume: 24
  04/01/2010 Authors: Wainford RD; Kapusta DR
• Peripheral vs central administration of NaCl differently modulates vasopressin secretion through the regulation of PVN G alpha q sub-unit proteins
  Volume: 24
  04/01/2010 Authors: Kapusta DR; Wainford RD
• A Novel Sympathoinhibitory Role of Central G alpha i(2)Subunit Proteins in Preventing the Development of Salt-Sensitive Hypertension
  Volume: 54 Page(s): E100 - E100
  10/01/2009 Authors: Wainford RD; Kapusta DR
• Central G alpha z Subunit Proteins Are Essential to Inhibit High Salt-Induced Increases in Vasopressin Secretion, Water Retention, and Development of Hypertension
  Volume: 54 Page(s): E100 - E100
  10/01/2009 Authors: Wainford RD; Kapusta DR
• The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures.
  Toxicol In Vitro Volume: 23 Page(s): 780 - 788
  08/01/2009 Authors: Wainford RD; Weaver RJ; Hawksworth GM
• Nociceptin/Orphanin FQ (N/OFQ) stimulated diuresis is mediated via inhibition of vasopressin secretion: a role for the hypothalamic paraventricular nucleus (PVN)
  Volume: 23
  04/01/2009 Authors: Wainford RD; Glatzer NR; Tasker JG; Kapusta DR
• Participation of central G-alpha i(2)-subunit proteins in blood pressure regulation and in countering salt-sensitive hypertension
  Volume: 23
  04/01/2009 Authors: Wainford RD; Kapusta DR
• Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system.
  Am J Physiol Regul Integr Comp Physiol Volume: 296 Page(s): R280 - R288
  02/01/2009 Authors: Wainford RD; Kapusta DR
• Central G alpha q protein mediated regulation of vasopressin (AVP) secretion during high salt challenge
  Volume: 52 Page(s): E61 - E62
  10/01/2008 Authors: Wainford RD; Kapusta DR
• Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.
  Am J Physiol Regul Integr Comp Physiol Volume: 295 Page(s): R535 - R542
  08/01/2008 Authors: Wainford RD; Kurtz K; Kapusta DR
• Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway.
  Toxicology Volume: 249 Page(s): 184 - 193
  07/30/2008 Authors: Wainford RD; Weaver RJ; Stewart KN; Brown P; Hawksworth GM
• Hypertensive Dahl salt-sensitive rats produce a blunted diuresis to central N/OFQ which is restored by CNS G-alpha q protein knockdown
  Volume: 22
  04/01/2008 Authors: Wainford RD; Kapusta DR
• Central but not peripheral G-alpha i/o protein inhibition potentiates hypertension in hypertensive Dahl salt-sensitive rats: a protective role for central G-alpha i/o proteins
  Volume: 22
  04/01/2008 Authors: Wainford RD; Kapusta DR
• Central G-protein regulation of cardiovascular and renal function in conscious Sprague-Dawley rats
  Volume: 50 Page(s): E116 - E116
  10/01/2007 Authors: Wainford RD; Kurtz K; Kapusta DR
• In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor.
  Peptides Volume: 28 Page(s): 1240 - 1251
  06/01/2007 Authors: Rizzi A; Spagnolo B; Wainford RD; Fischetti C; Guerrini R; Marzola G; Baldisserotto A; Salvadori S; Regoli D; Kapusta DR
• Central G alpha i and G alpha o protein inhibition by pertussis toxin (PTX) blocks the cardiovascular depressor but not diuretic response to central nociceptin/Orphanin FQ (N/OFQ) administration in conscious Sprague-Dawley rats
  Volume: 21 Page(s): A785 - A785
  04/01/2007 Authors: Wainford RD; Kurtz K; Kapusta DR
• Chronic high NaCl intake alters the cardiovascular and renal responses to central administration of the opioid-like peptide, nociceptin/Orphanin FQ (N/OFQ), in conscious rats: relationship to brain N/OFQ peptide (NOP) receptor expression and G-protein coupling
  Volume: 21 Page(s): A513 - A514
  04/01/2007 Authors: Wainford RD; Krutz K; Kapusta DR
• c-fos, c-jun and AP-1 expression following exposure of human and rat proximal tubular cell cultures to platinum analogues: Correlation with toxicity
  Volume: 202 Page(s): 61 - 61
  09/30/2004 Authors: Wainford RD; Descotes G; Weaver R; Merdjan H; Hawksworth GM
• Early markers of nephrotoxicity following exposure of human and rat proximal tubular cell cultures to platinum analogues
  Volume: 194 Page(s): 226 - 226
  01/15/2004 Authors: Wainford RD; Descotes G; Weaver R; Merdjan H; Hawksworth GM
• C-S lyase is not involved in Cis-platin nephrotoxicity in the rat
  Volume: 194 Page(s): 239 - 240
  01/15/2004 Authors: Wainford RD; Stewart KN; Descotes G; Weaver R; Merdjan H; Hawksworth GM
• Differential protection against cisplatin toxicity in rat and human proximal tubular cultures
  Volume: 178 Page(s): 59 - 60
  08/30/2002 Authors: Wainford RD; Descotes G; Merdjan H; Weaver R; Hawksworth GM
• Early markers of toxicity following administration of platinum analogues to rat and human proximal tubular cell cultures
  Volume: 34 Page(s): 99 - 99
  01/01/2002 Authors: Wainford RD; Descotes G; Weaver R; Merdjan H; Hawksworth GM
• Differential protective effects of acivicin, AOAA and N-acetyl-L-cysteine against cisplatin toxicity in rat and human proximal tubular cell cultures
  Volume: 34 Page(s): 98 - 98
  01/01/2002 Authors: Wainford RD; Descotes G; Weaver R; Merdjan H; Hawksworth GM