School of Medicine Homepage
Emory University Shield
  • About
    • Our Vision
    • Academic Departments
    • Our Leadership
    • Health Care Partnerships
    • Diversity, Equity, & Inclusion
    • Location
    • Supporting Our People
    • Our Faculty
    • History
    • News
    • Events
    • Contact Us
  • Education
    • Degree and Certificate Programs
    • Academic Departments
    • Residents & Fellows
    • Postdoctoral Training
    • Continuing Medical Education
    • Admissions
    • Cost and Financial Aid
    • Student Resources
  • Research
    • Research Innovation
    • Conducting Research
    • Core Facilities
    • Research Centers
    • Research Training
    • Academic Departments
    • Find a Researcher
    • Research News
  • Clinical Experience
    • Where We Work
    • Caring for a Diverse Population
    • Faculty Clinical Experience
    • Advanced Patient Care
    • Academic Departments
    • Community Learning
  • Giving
  • Directory

Directory section navigation

  • Faculty Profiles

Emory University School of Medicine

  • About
    • Sub link
      Our Vision
    • Sub link
      Academic Departments
    • Sub link
      Our Leadership
    • Sub link
      Health Care Partnerships
    • Sub link
      Diversity, Equity, & Inclusion
    • Sub link
      Location
    • Sub link
      Supporting Our People
    • Sub link
      Our Faculty
    • Sub link
      History
    • Sub link
      News
    • Sub link
      Events
    • Sub link
      Contact Us
  • Education
    • Sub link
      Degree and Certificate Programs
    • Sub link
      Academic Departments
    • Sub link
      Residents & Fellows
    • Sub link
      Postdoctoral Training
    • Sub link
      Continuing Medical Education
    • Sub link
      Admissions
    • Sub link
      Cost and Financial Aid
    • Sub link
      Student Resources
  • Research
    • Sub link
      Research Innovation
    • Sub link
      Conducting Research
    • Sub link
      Core Facilities
    • Sub link
      Research Centers
    • Sub link
      Research Training
    • Sub link
      Academic Departments
    • Sub link
      Find a Researcher
    • Sub link
      Research News
  • Clinical Experience
    • Sub link
      Where We Work
    • Sub link
      Caring for a Diverse Population
    • Sub link
      Faculty Clinical Experience
    • Sub link
      Advanced Patient Care
    • Sub link
      Academic Departments
    • Sub link
      Community Learning
  • Giving
  • Directory
  • Home School of Medicine Home
  • Directory

Profile

Rabindra Tirouvanziam PhD, Engineer

  • Department of Pediatrics
    Associate Professor
  • (404) 712-7684
  • tirouvanziam@emory.edu
  • Lab Website
  • MyNCBI
  • Emory Children's Center
    Pediatrics
    2015 Uppergate Dr, Rm 360
Head shot of Rabindra Tirouvanziam

Overview

The Tirouvanziam laboratory focuses on mechanisms of innate immunity in humans and their relations to chronic human disease. In recent years, these efforts have led us to conduct phase 1 and 2 interventional trials in CF (with CF Foundation and FDA support) and in autism, along with prospective studies in allergy and asthma.
Our group maintains active projects in other diseases and conditions affecting the respiratory system (chronic obstructive pulmonary disease, lung transplant), immune system (allergy, fungal colonization, malaria, Fanconi anemia) and central nervous system (autism, schizophrenia). We have fruitful collaborations with groups at several academic institutions, including Emory University, Georgia Tech, Stanford University, University of Alabama at Birmingham, University of Montpellier (France) and University of Lausanne (Switzerland).
Our approach emphasizes sample collection from patients and direct, high-content analyses by flow and image cytometry (to characterize metabolic and activation markers reflecting adaptation in immune cells) and mass spectrometry (to characterize small molecule signals exchanged by mucosal cells, viruses / bacteria / fungi and immune cells).
From an engineering standpoint, we are interested in identifying better in vivo targets and in developing adequate measurement methods to enable better immuno-inflammatory monitoring at the clinic and at home.

Academic Appointment

  • Assistant Professor, Department of Pediatrics, Emory University

Education

Degrees

  • PhD Developmental Biology, Immunology from Agro Paris-Tech
  • MSc from Paris 12 Val de Marne University, Paris
  • Engineer Biotechnology from Agro Paris-Tech

Research

Focus

  • The Tirouvanziam laboratory focuses on immunoinflammatory mechanisms involved in chronic diseases such as cystic fibrosis, allergy, and autism. We use high-content analysis of patient samples by flow / imaging cytometry and mass spectrometry, as well as culture systems, to identify new targets and endpoints for improved diagnostics, monitoring and therapy.

Publications

  • Suppression of LKB1-mutant lung adenocarcinoma by natural killer cells from females.
    J Natl Cancer Inst
    06/13/2025 Authors: Fan Y; Jin R; Monterroza L; Liu X; Huang C; Marra A; Mo X; Fu H; Gilbert-Ross M; Marcus AI
  • High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array.
    APL Bioeng Volume: 9 Page(s): 026110
    06/01/2025 Authors: Viola H; Chen L-H; Jo S; Washington K; Selva C; Li A; Feng D; Giacalone V; Stephenson ST; Cottrill K
  • Innate Immunity in Cystic Fibrosis: Varied Effects of CFTR Modulator Therapy on Cell-to-Cell Communication.
    Int J Mol Sci Volume: 26
    03/14/2025 Authors: Hynes J; Taggart CC; Tirouvanziam R; Coppinger JA
  • Inflammatory profiles in sputum and blood of people with TB with and without HIV coinfection.
    Tuberculosis (Edinb) Volume: 151 Page(s): 102612
    03/01/2025 Authors: Auld SC; Queiroz ATL; Araujo-Pereira M; Maenetje P; Mofokeng N; Mngomezulu L; Masilela D; Dobosh B; Tirouvanziam R; Kornfeld H
  • Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19.
    Sci Transl Med Volume: 16 Page(s): eadq1789
    11/06/2024 Authors: Babcock BR; Kosters A; Eddins DJ; Donaire MSB; Sarvadhavabhatla S; Pae V; Beltran F; Murray VW; Gill G; Xie G
  • Development of robust antiviral assays using relevant apical-out human airway organoids.
    bioRxiv
    07/12/2024 Authors: Lee J-H; LeCher JC; Parigoris E; Shinagawa N; Sentosa J; Manfredi C; Goh SL; De R; Tao S; Zandi K
  • Tumor-Intrinsic Enhancer of Zeste Homolog 2 Controls Immune Cell Infiltration, Tumor Growth, and Lung Metastasis in a Triple-Negative Breast Cancer Model.
    Int J Mol Sci Volume: 25
    05/15/2024 Authors: Monterroza L; Parrilla MM; Samaranayake SG; Rivera-Rodriguez DE; Yoon SB; Bommireddy R; Hosten J; Barragan LC; Marcus A; Dobosh BS
  • HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY.
    bioRxiv
    05/14/2024 Authors: Viola H; Chen L-H; Jo S; Washington K; Selva C; Li A; Feng D; Giacalone V; Stephenson ST; Cottrill K
  • Key inflammatory markers in bronchoalveolar lavage predict bronchiectasis progression in young children with CF.
    J Cyst Fibros Volume: 23 Page(s): 450 - 456
    05/01/2024 Authors: Horati H; Margaroli C; Chandler JD; Kilgore MB; Manai B; Andrinopoulou E-R; Peng L; Guglani L; Tiddens HAMW; Caudri D
  • Inflammatory profiles in sputum and blood of people with TB with and without HIV coinfection.

    04/24/2024 Authors: Auld SC; Queiroz ATL; Araujo-Pereira M; Maenetje P; Mofokeng N; Mngomezulu L; Masilela D; Dobosh B; Tirouvanziam R; Kornfeld H
  • Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections.
    Viruses Volume: 16
    04/22/2024 Authors: Hurwitz SJ; De R; LeCher JC; Downs-Bowen JA; Goh SL; Zandi K; McBrayer T; Amblard F; Patel D; Kohler JJ
  • Nasal airway inflammatory responses and pathogen detection in infants with cystic fibrosis.
    J Cyst Fibros Volume: 23 Page(s): 219 - 225
    03/01/2024 Authors: Kopp BT; Ross SE; Bojja D; Guglani L; Chandler JD; Tirouvanziam R; Thompson M; Slaven JE; Chmiel JF; Siracusa C
  • OMIP-100: A flow cytometry panel to investigate human neutrophil subsets.
    Cytometry A Volume: 105 Page(s): 81 - 87
    02/01/2024 Authors: Schofield CJ; Tirouvanziam R; Garratt LW
  • Substrate-dependent metabolomic signatures of myeloperoxidase activity in airway epithelial cells: Implications for early cystic fibrosis lung disease.
    Free Radic Biol Med Volume: 206 Page(s): 180 - 190
    09/01/2023 Authors: Kim SO; Shapiro JP; Cottrill KA; Collins GL; Shanthikumar S; Rao P; Ranganathan S; Stick SM; Orr ML; Fitzpatrick AM
  • The role of innate and adaptive immunity in the sex bias of LKB1-mutant lung adenocarcinoma
    Volume: 83
    04/01/2023 Authors: Fan Y; Monterroza L; Jin R; Liu X; Selvaraj P; Tirouvanziam R; Zhou W
  • Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load.
    Blood Adv Volume: 7 Page(s): 778 - 799
    03/14/2023 Authors: Eddins DJ; Yang J; Kosters A; Giacalone VD; Pechuan-Jorge X; Chandler JD; Eum J; Babcock BR; Dobosh BS; Hernndez MR
  • Pulmonary exacerbations in early cystic fibrosis lung disease are marked by strong modulation of CD3 and PD-1 on luminal T cells.
    Front Immunol Volume: 14 Page(s): 1194253
    01/01/2023 Authors: Giacalone VD; Giraldo DM; Silva GL; Hosten J; Peng L; Guglani L; Tirouvanziam R
  • Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease.
    Front Immunol Volume: 14 Page(s): 1202009
    01/01/2023 Authors: Slimmen LJM; Giacalone VD; Schofield C; Horati H; Mana BHAN; Estevo SC; Garratt LW; Peng L; Tirouvanziam R; Janssens HM
  • MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques.
    Sci Data Volume: 9 Page(s): 722
    11/24/2022 Authors: DeBarry JD; Nural MV; Pakala SB; Nayak V; Warrenfeltz S; Humphrey J; Lapp SA; Cabrera-Mora M; Brito CFA; Jiang J
  • Immunometabolic Analysis of Synovial Fluid from Juvenile Idiopathic Arthritis Patients.
    Immunohorizons Volume: 6 Page(s): 768 - 778
    11/01/2022 Authors: Giacalone VD; Cammarata-Mouchtouris A; Moncada-Giraldo D; Shenoy SPV; Ponder LA; Gergely TR; Kim SO; Chandler JD; Vega-Fernandez P; Manos CK
  • Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease.
    J Cyst Fibros Volume: 21 Page(s): 967 - 976
    11/01/2022 Authors: Margaroli C; Horati H; Garratt LW; Giacalone VD; Schofield C; Dittrich AS; Rosenow T; Dobosh BS; Lim HS; Frey DL
  • Neutrophil-derived extracellular vesicles promote feed-forward inflammasome signaling in cystic fibrosis airways.
    J Leukoc Biol Volume: 112 Page(s): 707 - 716
    10/01/2022 Authors: Forrest OA; Dobosh B; Ingersoll SA; Rao S; Rojas A; Laval J; Alvarez JA; Brown MR; Tangpricha V; Tirouvanziam R
  • Pilot study of inflammatory biomarkers in matched induced sputum and bronchoalveolar lavage of 2-year-olds with cystic fibrosis.
    Pediatr Pulmonol Volume: 57 Page(s): 2189 - 2198
    09/01/2022 Authors: Giacalone VD; Moncada-Giraldo D; Margaroli C; Brown MR; Silva GL; Chandler JD; Peng L; Tirouvanziam R; Guglani L; IMPEDE-CF Program
  • Inhibition of Recruitment and Activation of Neutrophils by Pyridazinone-Scaffold-Based Compounds.
    Int J Mol Sci Volume: 23
    06/29/2022 Authors: Moniot A; Braux J; Siboni R; Guillaume C; Audonnet S; Allart-Simon I; Sapi J; Tirouvanziam R; Grard S; Gangloff SC
  • Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes.
    Cell Rep Volume: 39 Page(s): 110945
    06/14/2022 Authors: Dobosh B; Zandi K; Giraldo DM; Goh SL; Musall K; Aldeco M; LeCher J; Giacalone VD; Yang J; Eddins DJ
  • Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study.
    Nutr Metab (Lond) Volume: 19 Page(s): 37
    05/21/2022 Authors: Bellissimo MP; Fleischer CC; Reiter DA; Goss AM; Zhou L; Smith MR; Kohlmeier J; Tirouvanziam R; Tran PH; Hao L
  • Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an invitro model of airway infection.
    Immunol Cell Biol Volume: 100 Page(s): 352 - 370
    05/01/2022 Authors: Laucirica DR; Schofield CJ; McLean SA; Margaroli C; Agudelo-Romero P; Stick SM; Tirouvanziam R; Kicic A; Garratt LW; Western Australian Epithelial Research Program (WAERP)
  • Inactivation of SARS-CoV-2 and COVID-19 Patient Samples for Contemporary Immunology and Metabolomics Studies.
    Immunohorizons Volume: 6 Page(s): 144 - 155
    02/16/2022 Authors: Eddins DJ; Bassit LC; Chandler JD; Haddad NS; Musall KL; Yang J; Kosters A; Dobosh BS; Hernndez MR; Ramonell RP
  • Autoantibodies to red blood cell surface Glycophorin A impact the activation poise of circulating leukocytes.
    Transfusion Volume: 62 Page(s): 217 - 226
    01/01/2022 Authors: Klein MN; Larkin EJ; Marshall JN; Fan X; Parry P; Tirouvanziam R; Fontaine MJ
  • Plasmodium knowlesi Cytoadhesion Involves SICA Variant Proteins.
    Front Cell Infect Microbiol Volume: 12 Page(s): 888496
    01/01/2022 Authors: Peterson MS; Joyner CJ; Lapp SA; Brady JA; Wood JS; Cabrera-Mora M; Saney CL; Fonseca LL; Cheng WT; Jiang J
  • A High-Throughput Distal Lung Air-Blood Barrier Model Enabled By Density-Driven Underside Epithelium Seeding.
    Adv Healthc Mater Volume: 11 Page(s): e2102450
    01/01/2022 Authors: Viola H; Washington K; Selva C; Grunwell J; Tirouvanziam R; Takayama S
  • Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi.
    Malar J Volume: 20 Page(s): 486
    12/30/2021 Authors: Peterson MS; Joyner CJ; Brady JA; Wood JS; Cabrera-Mora M; Saney CL; Fonseca LL; Cheng WT; Jiang J; Lapp SA
  • Mass production of human airway-like neutrophils via transmigration in an organotypic model of human airways.
    STAR Protoc Volume: 2 Page(s): 100892
    12/17/2021 Authors: Dobosh B; Giacalone VD; Margaroli C; Tirouvanziam R
  • Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
    J Cyst Fibros Volume: 20 Page(s): 941 - 948
    11/01/2021 Authors: Garratt LW; Breuer O; Schofield CJ; McLean SA; Laucirica DR; Tirouvanziam R; Clements BS; Kicic A; Ranganathan S; Stick SM
  • Mechanistic analysis and significance of sphingomyelinase-mediated decreases in transepithelial CFTR currents in nHBEs.
    Physiol Rep Volume: 9 Page(s): e15023
    09/01/2021 Authors: Cottrill KA; Giacalone VD; Margaroli C; Bridges RJ; Koval M; Tirouvanziam R; McCarty NA
  • Findings from a feasibility study of estradiol for hypogonadal women with cystic fibrosis-related bone disease.
    Pilot Feasibility Stud Volume: 7 Page(s): 160
    08/19/2021 Authors: Wu M; Tirouvanziam R; Arora N; Tangpricha V
  • A High-Throughput Distal Lung Air-Blood Barrier Model Enabled By Density-Driven Underside Epithelium Seeding.
    Adv Healthc Mater Volume: 10 Page(s): e2100879
    08/01/2021 Authors: Viola H; Washington K; Selva C; Grunwell J; Tirouvanziam R; Takayama S
  • Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophils.
    Cell Rep Med Volume: 2 Page(s): 100239
    04/20/2021 Authors: Margaroli C; Moncada-Giraldo D; Gulick DA; Dobosh B; Giacalone VD; Forrest OA; Sun F; Gu C; Gaggar A; Kissick H
  • Elevated levels of inflammatory plasma biomarkers are associated with risk of HIV infection.
    Retrovirology Volume: 18 Page(s): 8
    03/17/2021 Authors: McInally S; Wall K; Yu T; Tirouvanziam R; Kilembe W; Gilmour J; Allen SA; Hunter E
  • Functional and Transcriptional Adaptations of Blood Monocytes Recruited to the Cystic Fibrosis Airway Microenvironment In Vitro.
    Int J Mol Sci Volume: 22
    03/03/2021 Authors: Ford BD; Moncada Giraldo D; Margaroli C; Giacalone VD; Brown MR; Peng L; Tirouvanziam R
  • Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease.
    Exp Dermatol Volume: 29 Page(s): 1191 - 1198
    12/01/2020 Authors: Margaroli C; Bradley B; Thompson C; Brown MR; Giacalone VD; Bhatt L; Stoff B; Ahuja S; Springman E; Tirouvanziam R
  • Oral Glutathione and Growth in Cystic Fibrosis: A Multicenter, Randomized, Placebo-controlled, Double-blind Trial.
    J Pediatr Gastroenterol Nutr Volume: 71 Page(s): 771 - 777
    12/01/2020 Authors: Bozic M; Goss CH; Tirouvanziam RM; Baines A; Kloster M; Antoine L; Borowitz D; Schwarzenberg SJ; GROW study group
  • MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.
    Mol Psychiatry Volume: 25 Page(s): 2889 - 2904
    11/01/2020 Authors: Dwir D; Giangreco B; Xin L; Tenenbaum L; Cabungcal J-H; Steullet P; Goupil A; Cleusix M; Jenni R; Chtarto A
  • Airway profile of bioactive lipids predicts early progression of lung disease in cystic fibrosis.
    J Cyst Fibros Volume: 19 Page(s): 902 - 909
    11/01/2020 Authors: Horati H; Janssens HM; Margaroli C; Veltman M; Stolarczyk M; Kilgore MB; Chou J; Peng L; Tiddens HAMW; Chandler JD
  • Correction: MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.
    Mol Psychiatry Volume: 25 Page(s): 3105
    11/01/2020 Authors: Dwir D; Giangreco B; Xin L; Tenenbaum L; Cabungcal J-H; Steullet P; Goupil A; Cleusix M; Jenni R; Chtarto A
  • IMPACT OF ESTROGEN ON QUALITY OF LIFE AND BONE ACCRUAL FOR WOMEN WITH CF
    Volume: 55 Page(s): S85 - S85
    10/01/2020 Authors: Wu M; Bettermann E; Arora N; Hunt WR; Tirouvanziam R; McCracken C; Tangpricha V
  • INDUCED SPUTUM COLLECTION AS A NON-INVASIVE METHOD TO INVESTIGATE INFLAMMATORY MARKERS OF EARLY CF LUNG DISEASE
    Volume: 55 Page(s): S42 - S42
    10/01/2020 Authors: Giacalone VD; Moncada DM; Margaroli C; Brown M; Silva GL; Peng L; Chandler JD; Tirouvanziam R; Guglani L
  • METABOLOMICS OF INDUCED SPUTUM IN EARLY CYSTIC FIBROSIS
    Volume: 55 Page(s): S52 - S53
    10/01/2020 Authors: Moncada DM; Giacalone VD; Kilgore MB; Brown M; Silva GL; Esther CR; Tirouvanziam R; Guglani L; Chandler JD
  • VIRAL-BACTERIAL CO-INFECTION INDUCES A PATHOLOGICAL NEUTROPHIL PHENOTYPE OBSERVED IN CYSTIC FIBROSIS AIRWAYS
    Volume: 25 Page(s): 53 - 53
    06/01/2020 Authors: Laucirica D; Schofield C; Mclean S; Margaroli C; Stick S; Tirouvanziam R; Kicic A; Garratt L; Waerp; Arest CF
  • Immunomodulation in Cystic Fibrosis: Why and How?
    Int J Mol Sci Volume: 21
    05/08/2020 Authors: Giacalone VD; Dobosh BS; Gaggar A; Tirouvanziam R; Margaroli C
  • Transcriptional reprogramming drives neutrophil phenotype and function in chronic lung disease
    Volume: 204
    05/01/2020 Authors: Margaroli C; Giraldo DM; Arafat-Gulick D; Dobosh B; Giacalone V; Kissick H; Forrest OA; Gu C; Gibson G; Tirouvanziam RM
  • CD3 downregulation on T-cells is concomitant with arginase upregulation on myeloid cells in the synovial fluid of patients with juvenile idopathic arthritis
    Volume: 204
    05/01/2020 Authors: Giacalone VD; Cammarata-Mouchtouris A; Moncada D; Shenoy S; Ponder L; Gergely T; Vega-Fernandez P; Manos C; Flanagan E; Prahalad S
  • Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease.
    Int J Mol Sci Volume: 21
    01/28/2020 Authors: Giacalone VD; Margaroli C; Mall MA; Tirouvanziam R
  • The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients.
    Oncoimmunology Volume: 9 Page(s): 1747731
    01/01/2020 Authors: Margaroli C; Cardenas MA; Jansen CS; Moon Reyes A; Hosseinzadeh F; Hong G; Zhang Y; Kissick H; Tirouvanziam R; Master VA
  • Neutrophil-targeted, protease-activated pulmonary drug delivery blocks airway and systemic inflammation.
    JCI Insight Volume: 4
    12/05/2019 Authors: Mejas JC; Forrest OA; Margaroli C; Frey Rubio DA; Viera L; Li J; Xu X; Gaggar A; Tirouvanziam R; Roy K
  • Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair.
    APL Bioeng Volume: 3 Page(s): 041503
    12/01/2019 Authors: Viola H; Chang J; Grunwell JR; Hecker L; Tirouvanziam R; Grotberg JB; Takayama S
  • DISCOVERY OF AIRWAY FLUID PROTEINS ASSOCIATED WITH PROGRESSIVE AIRWAY DISEASE IN YOUNG CHILDREN WITH CYSTIC FIBROSIS
    Volume: 54 Page(s): S328 - S328
    10/01/2019 Authors: Chou J; Horati H; Margaroli C; Tiddens HA; Scholte BJ; Chandler JD; Tirouvanziam R; Janssens HM; Peng L
  • SUBSETTING OF EXTRACELLULAR VESICLES FROM ADULT CYSTIC FIBROSIS PATIENTS BASED ON SURFACE NEUTROPHIL ELASTASE LEVELS
    Volume: 54 Page(s): S211 - S211
    10/01/2019 Authors: Dobosh B; Liu S; Chen M; Strickland K; Tirouvanziam R
  • ACTIVE TRANSCRIPTIONAL MODULATION OF PATHOLOGICAL EXTRACELLULAR VESICLES BY HUMAN CF AIRWAY NEUTROPHILS
    Volume: 54 Page(s): S156 - S156
    10/01/2019 Authors: Margaroli C; Dobosh B; Giraldo MD; Arafat-Gulick D; Kissick H; Forrest OA; Sun F; Wu R; Gibson G; Tirouvanziam R
  • INDUCED SPUTUM AS AN ALTERNATIVE TO BRONCHOALVEOLAR LAVAGE FOR EVALUATION OF AIRWAY INFLAMMATION IN YOUNG CHILDREN WITH CYSTIC FIBROSIS
    Volume: 54 Page(s): S157 - S158
    10/01/2019 Authors: Giacalone VD; Margaroli C; Dobosh B; Brown M; Silva GL; Peng L; Chandler JD; Tirouvanziam R; Guglani L
  • FEASIBILITY OF EXHALED BREATH CONDENSATE COLLECTION AND METABOLOMICS IN YOUNG CHILDREN WITH CYSTIC FIBROSIS: A PILOT STUDY
    Volume: 54 Page(s): S341 - S341
    10/01/2019 Authors: Chandler JD; Kilgore MB; Silva GL; Peng L; Tirouvanziam R; Guglani L
  • SKELETAL AND REPRODUCTIVE HEALTH IN PREMENOPAUSAL WOMEN WITH CF
    Volume: 54 Page(s): S227 - S227
    10/01/2019 Authors: Wu M; Hunt WR; Tirouvanziam R; Tangpricha V
  • Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes.
    PLoS Pathog Volume: 15 Page(s): e1007974
    09/01/2019 Authors: Joyner CJ; Brito CFA; Saney CL; Joice Cordy R; Smith ML; Lapp SA; Cabrera-Mora M; Kyu S; Lackman N; Nural MV
  • Single-Step Purification of Sputum Extracellular vesicles from Cystic Fibrosis patients using aF4-MALS
    Volume: 202
    05/01/2019 Authors: Dobosh B; Liu S; Chen M; Tirouvanziam RM
  • Leukotriene B4 pathway and tissue damage markers are expressed by granulocytes in lesional skin in bullous pemphigoid
    Volume: 139 Page(s): S179 - S179
    05/01/2019 Authors: Margaroli C; Bradley B; Bhatt L; Ahuja S; Springman E; Tirouvanziam R; Feldman RJ
  • Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis.
    Am J Respir Crit Care Med Volume: 199 Page(s): 873 - 881
    04/01/2019 Authors: Margaroli C; Garratt LW; Horati H; Dittrich AS; Rosenow T; Montgomery ST; Frey DL; Brown MR; Schultz C; Guglani L
  • MINIATURISATION OF AN IN VITRO TRANSMIGRATION MODEL OF NEUTROPHIL RECRUITMENT TO CYSTIC FIBROSIS AIRWAYS
    Volume: 24 Page(s): 117 - 117
    03/01/2019 Authors: Laucirica D; Mclean S; Schofield C; Margaroli C; Stick S; Tirouvanziam R; Kicic A; Garratt L; Arest CF
  • Vitamin D for the Immune System in Cystic Fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled clinical trial.
    Am J Clin Nutr Volume: 109 Page(s): 544 - 553
    03/01/2019 Authors: Tangpricha V; Lukemire J; Chen Y; Binongo JNG; Judd SE; Michalski ES; Lee MJ; Walker S; Ziegler TR; Tirouvanziam R
  • Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections.
    Sci Rep Volume: 9 Page(s): 2874
    02/27/2019 Authors: Grunwell JR; Giacalone VD; Stephenson S; Margaroli C; Dobosh BS; Brown MR; Fitzpatrick AM; Tirouvanziam R
  • Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance.
    J Allergy Clin Immunol Pract Volume: 7 Page(s): 516 - 525.e6
    02/01/2019 Authors: Grunwell JR; Stephenson ST; Tirouvanziam R; Brown LAS; Brown MR; Fitzpatrick AM
  • Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.
    Cell Volume: 176 Page(s): 113 - 126.e15
    01/10/2019 Authors: Genschmer KR; Russell DW; Lal C; Szul T; Bratcher PE; Noerager BD; Abdul Roda M; Xu X; Rezonzew G; Viera L
  • Resistin is elevated in cystic fibrosis sputum and correlates negatively with lung function.
    J Cyst Fibros Volume: 18 Page(s): 64 - 70
    01/01/2019 Authors: Forrest OA; Chopyk DM; Gernez Y; Brown MR; Conrad CK; Moss RB; Tangpricha V; Peng L; Tirouvanziam R
  • Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis.
    J Leukoc Biol Volume: 104 Page(s): 665 - 675
    10/01/2018 Authors: Forrest OA; Ingersoll SA; Preininger MK; Laval J; Limoli DH; Brown MR; Lee FE; Bedi B; Sadikot RT; Goldberg JB
  • Determination of thiocyanate in exhaled breath condensate.
    Free Radic Biol Med Volume: 126 Page(s): 334 - 340
    10/01/2018 Authors: Chandler JD; Horati H; Walker DI; Pagliano E; Tirouvanziam R; Veltman M; Scholte BJ; Janssens HM; Go Y-M; Jones DP
  • Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease.
    Eur Respir J Volume: 52
    10/01/2018 Authors: Chandler JD; Margaroli C; Horati H; Kilgore MB; Veltman M; Liu HK; Taurone AJ; Peng L; Guglani L; Uppal K
  • EXPRESSION OF THE EXHAUSTION MARKER PROGRAMMED CELL DEATH 1 ON AIRWAY MACROPHAGES CORRELATES POSITIVELY WITH EARLY CYSTIC FIBROSIS LUNG DISEASE
    Volume: 53 Page(s): 190 - 190
    09/01/2018 Authors: Horati H; Margaroli C; Scholte BJ; Veltman M; Peng L; Tiddens HA; Gugliani L; Tirouvanziam R; Janssens HM
  • OXIDATIVE STRESS IN CF AIRWAYS CONTROLS CYTOKINE AND GROWTH FACTOR SHEDDING AND CORRELATES WITH LUNG DISEASE
    Volume: 53 Page(s): 189 - 189
    09/01/2018 Authors: Scholte BJ; Horati H; Veltman M; Margaroli C; Tiddens HA; Tirouvanziam R; Janssens HM
  • METHIONINE OXIDATION BY MYELOPEROXIDASE IS ASSOCIATED WITH EARLY CYSTIC FIBROSIS LUNG DISEASE
    Volume: 53 Page(s): 262 - 262
    09/01/2018 Authors: Chandler JD; Margaroli C; Horati H; Kilgore MB; Veltman M; Liu HK; Taurone AJ; Peng L; Guglani L; Uppal K
  • TRANSMIGRATION INTO THE CF AIRWAY MICROENVIRONMENT ALTERS MONOCYTE PHENOTYPE AND METABOLISM
    Volume: 53 Page(s): 175 - 175
    09/01/2018 Authors: Ford BD; Margaroli C; Forrest OA; Brown M; Tirouvanziam R
  • TRANSCRIPTIONAL ADAPTATION IN NEUTROPHILS RECRUITED TO CYSTIC FIBROSIS AIRWAYS UNDERLIES CHANGES IN CANONICAL IMMUNE FUNCTIONS
    Volume: 53 Page(s): 186 - 186
    09/01/2018 Authors: Margaroli C; Arafat-Gulick D; Kissick H; Forrest OA; Sun F; Garimalla S; Wu R; Gibson G; Tirouvanziam R
  • Adenosine Production by Biomaterial-Supported Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response in Myocardial Ischemia/Reperfusion Injury.
    J Am Heart Assoc Volume: 7
    01/13/2018 Authors: Shin EY; Wang L; Zemskova M; Deppen J; Xu K; Strobel F; Garca AJ; Tirouvanziam R; Levit RD
  • Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine.
    J Innate Immun Volume: 10 Page(s): 487 - 501
    01/01/2018 Authors: Hartl D; Tirouvanziam R; Laval J; Greene CM; Habiel D; Sharma L; Yildirim A; Dela Cruz CS; Hogaboam CM
  • CD73-Mediated Adenosine Production by Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response Following Myocardial Ischemia/Reperfusion Injury
    Volume: 136
    11/14/2017 Authors: Shin EY; Wang L; Zemskova M; Deppen J; Xu K; Garcia AJ; Dahlman J; Tirouvanziam R; Levit RD
  • Leukocyte and plasma activation profiles in chronically transfused patients with a history of allergic reactions.
    Transfusion Volume: 57 Page(s): 2639 - 2648
    11/01/2017 Authors: Fontaine MJ; Shih H; Schubert R; Wong W; Andrews J; Jeng M; Tirouvanziam R
  • CYNOMOLGI MALARIA IN RHESUS MACAQUES INDUCES PHENOTYPIC AND FUNCTIONAL CHANGES IN NEUTROPHILS
    Volume: 95 Page(s): 416 - 416
    11/01/2017 Authors: Joyner C; Lamb TJ; Ibegbu CC; Tirouvanziam R; Galinski MR
  • A MULTI-'OMIC SYSTEMS BIOLOGY APPROACH TO IDENTIFYING HOST AND PARASITE FEATURES THAT CONFER RESILIENCE TO MALARIA INFECTION
    Volume: 95 Page(s): 263 - 264
    11/01/2017 Authors: Joice R; Tirouvanziam R; Gutierrez JB; Moreno A; Kissinger JC; Galinski MR
  • Corrigendum to "Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration" [Metabolism vol. 70, May 2017, pages 31-41].
    Metabolism Volume: 74 Page(s): 41 - 42
    09/01/2017 Authors: Alvarez JA; Chong EY; Walker DI; Chandler JD; Michalski ES; Grossmann RE; Uppal K; Li S; Frediani JK; Tirouvanziam R
  • HIGH-DOSE VITAMIN D3 DURING ACUTE PULMONARY EXACERBATION IN CYSTIC FIBROSIS: A MULTI-CENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
    Volume: 52 Page(s): S471 - S472
    09/01/2017 Authors: Tangpricha V; Michalski E; Lukemire J; Binongo J; Judd S; Ziegler T; Walker SD; Tirouvanziam R; Zughaier S; Lee M
  • HUMAN RESISTIN IS COMPARTMENTALIZED ON EXTRACELLULAR VESICLES IN CYSTIC FIBROSIS AIRWAY FLUID
    Volume: 52 Page(s): S334 - S334
    09/01/2017 Authors: Forrest OA; Brown M; Alvarez J; Tangpricha V; Tirouvanziam R
  • MIGRATION INTO CF AIRWAY FLUID PROMOTES ADAPTIVE TRANSCRIPTIONAL REPROGRAMMING OF HUMAN NEUTROPHILS IN VIVO AND IN VITRO
    Volume: 52 Page(s): S243 - S243
    09/01/2017 Authors: Margaroli C; Arafat-Gulick D; Kissick H; Forrest OA; Garimalla S; Gibson G; Tirouvanziam R
  • GRANULE EXOCYTOSIS BY AIRWAY NEUTROPHILS CORRELATES WITH PRAGMA-CF SCORE OF STRUCTURAL AIRWAY DAMAGE IN EARLY CF LUNG DISEASE
    Volume: 52 Page(s): S314 - S314
    09/01/2017 Authors: Horati H; Margaroli C; Scholte BJ; Veltman M; Peng L; Tiddens HA; Tirouvanziam R; Janssens HM
  • Abstract 146: Adenosine Production by Biomaterial-supported Mesenchymal Stromal Cells Reduces the Innate Inflammatory Response in Myocardial Ischemia/Reperfusion Injury
    Volume: 121
    07/21/2017 Authors: Shin EY; Wang L; Zemskova M; Deppen J; Xu K; Garcia AJ; Tirouvanziam R; Levit RD
  • The Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC) trial: Rationale and design of a multi-center, double-blind, placebo-controlled trial of high dose bolus administration of vitamin D3 during acute pulmonary exacerbation of cystic fibrosis.
    Contemp Clin Trials Commun Volume: 6 Page(s): 39 - 45
    06/01/2017 Authors: Tangpricha V; Smith EM; Binongo J; Judd SE; Ziegler TR; Walker S; Tirouvanziam R; Zughaier SM; Lee MJ; Chesdachai S
  • Plasma metabolomics in adults with cystic fibrosis during a pulmonary exacerbation: A pilot randomized study of high-dose vitamin D3 administration.
    Metabolism Volume: 70 Page(s): 31 - 41
    05/01/2017 Authors: Alvarez JA; Chong EY; Walker DI; Chandler JD; Michalski ES; Grossmann RE; Uppal K; Li S; Frediani JK; Tirouvanziam R
  • CHARACTERIZATION OF PHYSIOLOGICAL SIGNATURES OF PLASMODIUM INFECTIONS IN NONHUMAN PRIMATES USING A CONTINUOUS TELEMETRY SYSTEM
    Volume: 97 Page(s): 619 - 619
    01/01/2017 Authors: Brady J; Cabrera-Mora M; Hankus A; Karpuzoglu E; Wood JS; Humphrey JC; Nural MV; DeBarry J; Tirouvanziam R; Moreno A
  • Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease.
    Mol Cell Pediatr Volume: 3 Page(s): 38
    12/01/2016 Authors: Margaroli C; Tirouvanziam R
  • Mesenchymal Stem Cells Require CD73 Activity to Reduce Leukocyte Associated Inflammation Following Myocardial Ischemia-Reperfusion Injury
    Volume: 134
    11/11/2016 Authors: Shin E; Wang L; Garcia A; Tirouvanziam R; Levit R
  • IN VITRO TRANSMIGRATION OF NEUTROPHILS INTO CF AIRWAY FLUID INDUCES FUNCTIONAL AND METABOLIC REPROGRAMMING CHARACTERISTIC OF CF AIRWAY NEUTROPHILS IN VIVO
    Volume: 51 Page(s): 241 - 241
    10/01/2016 Authors: Forrest OA; Ingersoll S; Preininger M; Laval J; Limoli D; Brown MR; Lee F; Bedi B; Bedi B; Sadikot RT
  • RESISTIN, A NEUTROPHIL-DERIVED IMMUNOMETABOLIC MEDIATOR, IS A CELL-SURFACE ASSOCIATED AND SOLUBLE MARKER OF EARLY AND CHRONIC CF AIRWAY DISEASE
    Volume: 51 Page(s): 297 - 297
    10/01/2016 Authors: Forrest OA; Chopyk D; Ingersoll S; Brown MR; Scholte BJ; Janssens H; Alvarez JA; Tangpricha V; Tirouvanziam R
  • EFFECT OF INHALED CORTICOSTEROID THERAPY WITHDRAWAL ON CF LUNG FUNCTION AND INFLAMMATORY MARKERS
    Volume: 51 Page(s): 236 - 236
    10/01/2016 Authors: Beaty TC; Brown MR; Forrest OA; Ingersoll S; Stecenko A; Tirouvanziam R
  • UNTARGETED METABOLOMICS OF CF INFANT BALF IDENTIFIES SIGNATURES ASSOCIATED WITH EARLY AIRWAY DISEASE BASED ON PRAGMA CT SCORING
    Volume: 51 Page(s): 236 - 237
    10/01/2016 Authors: Chandler JD; Horati H; Scholte BJ; Jones DP; Peng L; Gaggar A; Janssens H; Tirouvanziam R
  • Basophil activation test determination of CD63 combined with CD203c is not superior to CD203c alone in identifying allergic bronchopulmonary aspergillosis in cystic fibrosis.
    J Allergy Clin Immunol Volume: 138 Page(s): 1195 - 1196
    10/01/2016 Authors: Gernez Y; Waters J; Tirouvanziam R; Herzenberg L; Moss R
  • BIOACTIVE LIPIDS IN BRONCHOALVEOLAR LAVAGE OF CF INFANTS CORRELATE WITH LUNG CT SCORE, REVEALING THERAPEUTIC TARGETS
    Volume: 51 Page(s): 268 - 268
    10/01/2016 Authors: Scholte BJ; Veltman M; Horati H; Koval S; Vreeken R; Harms A; Tiddens H; Janssens H; Tirouvanziam R; Stick SM
  • Functional and metabolic reprogramming drives the development of a pathogenic subset of neutrophils in inflammatory airway diseases
    Volume: 46 Page(s): 251 - 252
    08/01/2016 Authors: Forrest O; Ingersoll S; Preininger M; Laval J; Limoli D; Brown M; Lee F; Bedi B; Sadikot R; Goldberg J
  • Mesenchymal Stem Cells Reduce Neutrophil Mediated Inflammation Following Myocardial Ischemia-reperfusion Injury
    Volume: 119
    07/22/2016 Authors: Shin E; Zemskova M; Wang L; Tirouvanziam R; Garcia A; Taylor WR; Levit R
  • "Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis." Yael Gernez, Jeffrey Waters, Bojana Mirkovi, Gillian M. Lavelle, Colleen E. Dunn, Zoe A. Davies, Cassie Everson, Rabindra Tirouvanziam, Elana Silver, Sylvan Wallenstein, Sanjay H. Chotirmall, Noel G. McElvaney, Leonore A. Herzenberg and Richard B. Moss. Eur Respir J 2016; 47: 177-185.
    Eur Respir J Volume: 47 Page(s): 1892
    06/01/2016
  • Interaction Between Redox Dysregulation and Neuroinflammation During Early Development Could Lead to PVI Circuitry Impairments an Adulthood: Relevance for Schizophrenia
    Volume: 79 Page(s): 344S - 344S
    05/01/2016 Authors: Dwir D; Cabungcal J-H; Tenebaum L; Steullet P; Cuenod M; Tirouvanziam R; Do KQ
  • Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.
    Am J Respir Cell Mol Biol Volume: 54 Page(s): 359 - 369
    03/01/2016 Authors: Szul T; Bratcher PE; Fraser KB; Kong M; Tirouvanziam R; Ingersoll S; Sztul E; Rangarajan S; Blalock JE; Xu X
  • Modulatory Effects of Aspergillus Colonization and Abpa on Blood and Sputum Granulocytes in CF
    Volume: 137 Page(s): AB29 - AB29
    02/01/2016 Authors: Gernez Y; Waters J; Dunn CE; Davies Z; Everson C; Tirouvanziam R; Herzenberg L; Moss RB
  • Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis.
    Eur Respir J Volume: 47 Page(s): 177 - 185
    01/01/2016 Authors: Gernez Y; Waters J; Mirkovi B; Lavelle GM; Dunn CE; Davies ZA; Everson C; Tirouvanziam R; Silver E; Wallenstein S
  • High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial.
    Int J Chron Obstruct Pulmon Dis Volume: 11 Page(s): 799 - 807
    01/01/2016 Authors: Johnson K; McEvoy CE; Naqvi S; Wendt C; Reilkoff RA; Kunisaki KM; Wetherbee EE; Nelson D; Tirouvanziam R; Niewoehner DE
  • Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor.
    J Cyst Fibros Volume: 15 Page(s): 67 - 73
    01/01/2016 Authors: Bratcher PE; Rowe SM; Reeves G; Roberts T; Szul T; Harris WT; Tirouvanziam R; Gaggar A
  • IDENTIFICATION OF SMALL METABOLITES ASSOCIATED WITH METASTABLE AND ACUTE CYSTIC FIBROSIS AIRWAY DISEASE BY HIGH-RESOLUTION METABOLOMICS
    Volume: 50 Page(s): 228 - 228
    10/01/2015 Authors: Ingersoll S; Bernardin N; Tangpricha V; Alvarez JA; Ziegler TR; Jones DP; Tirouvanziam R
  • SPHINGOSINE 1-PHOSPHATE RECEPTOR 3 IS HIGHLY UPREGULATED ON HUMAN NEUTROPHILS UPON MIGRATION TO THE AIRWAYS
    Volume: 50 Page(s): 243 - 243
    10/01/2015 Authors: Ingersoll S; Forrest OA; Brown MR; Tirouvanziam R
  • Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.
    J Immunol Volume: 194 Page(s): 5520 - 5528
    06/01/2015 Authors: Ingersoll SA; Laval J; Forrest OA; Preininger M; Brown MR; Arafat D; Gibson G; Tangpricha V; Tirouvanziam R
  • Sphingosine 1-phosphate receptor 3 is highly upregulated on human neutrophils upon migration to the airways
    Volume: 194
    05/01/2015 Authors: Ingersoll S; Forrest O; Brown M; Tirouvanziam R
  • Increased survival and exocytosis of toxic primary granules by neutrophils in an in vitro model of Cystic Fibrosis airway disease
    Volume: 194
    05/01/2015 Authors: Forrest O; Ingersoll S; Preininger M; Laval J; Brown M; Tirouvanziam R
  • Human resistin, a neutrophil-derived metabolic and inflammatory mediator correlates with decreased lung function and NETosis in cystic fibrosis airway disease
    Volume: 194
    05/01/2015 Authors: Forrest O; Chopyk D; Ingersoll S; Yoo D-G; Brown M; Tangpricha V; Tirouvanziam R; Rada B
  • Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
    PLoS Pathog Volume: 11 Page(s): e1004770
    03/01/2015 Authors: Napier RJ; Norris BA; Swimm A; Giver CR; Harris WAC; Laval J; Napier BA; Patel G; Crump R; Peng Z
  • RECEPTOR FOR ADVANCED GLYCATION END-PRODUCT (RAGE) AS LINKING MECHANISM BETWEEN NEUROINFLAMMATION AND OXIDATIVE STRESS
    Volume: 41 Page(s): S2 - S3
    03/01/2015 Authors: Do KQ; Dwir D; Cabungcal JH; Tirouvanziam R; Cuenod M
  • Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial.
    J Cyst Fibros Volume: 14 Page(s): 219 - 227
    03/01/2015 Authors: Conrad C; Lymp J; Thompson V; Dunn C; Davies Z; Chatfield B; Nichols D; Clancy J; Vender R; Egan ME
  • COMBINED IN VIVO AND IN VITRO ANALYSES IDENTIFY THE CASPASE-1/TRPM2 AXIS AS A CONTRIBUTOR TO NEUTROPHIL-DRIVEN AIRWAY INFLAMMATION IN CYSTIC FIBROSIS
    PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 280 - 281
    09/01/2014 Authors: Forrest O; Ingersoll S; Robertson AA; Preininger M; Laval J; Brown M; O'Neill L; Cooper MA; Tangpricha V; Tirouvanziam R
  • HUMAN RESISTIN, A NEUTROPHIL-DERIVED METABOLIC AND INFLAMMATORY MEDIATOR, REACHES STRIKINGLY HIGH LEVELS IN CYSTIC FIBROSIS AIRWAY FLUID
    PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 295 - 296
    09/01/2014 Authors: Forrest O; Chopyk D; Ingersoll S; Brown M; Conrad C; Tangpricha V; Tirouvanziam R
  • DYNAMIC EXPRESSION OF T-CELL SUPPRESSIVE MOLECULES ARGINASE-1 AND PROGRAMMED DEATH LIGAND-1 BY MATURE AIRWAY NEUTROPHILS IN CYSTIC FIBROSIS
    PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 264 - 264
    09/01/2014 Authors: Ingersoll S; Forrest O; Laval J; Preininger M; Brown M; Tangpricha V; Tirouvanziam R
  • DISCOVERY-BASED, HIGH-RESOLUTION PLASMA METABOLOMICS FOLLOWING A VITAMIN D-3 INTERVENTION IN ADULT PATIENTS WITH CYSTIC FIBROSIS
    PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 418 - 419
    09/01/2014 Authors: Alvarez JA; Smith EM; Jones DP; Grossmann RE; Frediani JK; Uppal K; Tirouvanziam R; Tangpricha V; Ziegler TR
  • IVACAFTOR TREATMENT RESULTS IN MODULATION OF BLOOD LEUKOCYTE ACTIVATION IN CYSTIC FIBROSIS PATIENTS WITH THE G551D CFTR MUTATION
    PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 303 - 303
    09/01/2014 Authors: Bratcher PE; Rowe SM; Szul T; Harris WT; Tirouvanziam R; Gaggar A
  • EXOCYTOSIS OF TOXIC PRIMARY GRANULES BY HUMAN NEUTROPHILS IS ASSOCIATED WITH HIGH SURFACE TRPM2 EXPRESSION AND PINOCYTOSIS
    Volume: 49 Page(s): 265 - 266
    09/01/2014 Authors: Ingersoll S; Forrest O; Bowen J; Brown M; Tirouvanziam R
  • CTX-4430, A CANDIDATE LTA4H INHIBITOR, DOWNREGULATES NEUTROPHIL TRANSMIGRATION THROUGH HUMAN BRONCHIOLAR EPITHELIUM IN VITRO
    Volume: 49 Page(s): 290 - 291
    09/01/2014 Authors: Tirouvanziam R; Forrest O; Springman EB
  • CFTR, NEUTROPHILS, INFLAMMATION AND THE LUNG IN CF
    Volume: 49 Page(s): 203 - 204
    09/01/2014 Authors: Tirouvanziam R
  • Exocytosis of toxic primary granules by human neutrophils is associated with high surface TRPM2 expression and pinocytosis
    Volume: 192
    05/01/2014 Authors: Tirouvanziam R; Forrest O; Bowen J; Brown M; Ingersoll S
  • Involvement of the Receptor for Advanced Glycation End-product (RAGE) in Redox Dysregulation and Neuroinflammation in an Animal Model of Schizophrenia
    Volume: 75 Page(s): 185S - 186S
    05/01/2014 Authors: Dwir D; Cabungcal J-H; Steullet P; Fournier M; Tirouvanziam R; Do KQ
  • PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06.
    Mol Imaging Biol Volume: 16 Page(s): 109 - 117
    02/01/2014 Authors: Lartey FM; Ahn G-O; Shen B; Cord K-T; Smith T; Chua JY; Rosenblum S; Liu H; James ML; Chernikova S
  • Basophil Activation Is a Reliable Biomarker Of Allergic Bronchopulmonary Aspergillosis (ABPA) In CF: One Year Results Of a Longitudinal Cohort Study
    Volume: 133 Page(s): AB58 - AB58
    02/01/2014 Authors: Gernez Y; Waters J; Dunn C; Davies Z; Tirouvanziam R; Everson C; Tamaresis J; Herzenberg L; Moss RB
  • ARGINASE-1 AND PROGRAMMED CELL DEATH LIGAND 1, POTENT INDUCERS OF IMMUNE TOLERANCE, ARE UPREGULATED ON AIRWAY NEUTROPHILS IN CYSTIC FIBROSIS
    Volume: 48 Page(s): 258 - 258
    10/01/2013 Authors: Ingersoll S; Laval J; Preininger M; Brown M; Tirouvanziam R
  • A 3D MODEL RECAPITULATING THE PATHOLOGICAL PHENOTYPE OF NEUTROPHILS IN CYSTIC FIBROSIS AIRWAYS
    Volume: 48 Page(s): 234 - 234
    10/01/2013 Authors: Preininger M; Laval J; Ingersoll S; Tirouvanziam R
  • MOLECULAR COMPONENTS OF THE INSULIN/INSULIN-LIKE GROWTH FACTOR-1 SIGNALING PATHWAY ARE HIGHLY EXPRESSED BY AIRWAY NEUTROPHILS IN CYSTIC FIBROSIS AND CYSTIC FIBROSIS-RELATED DIABETES
    Volume: 48 Page(s): 242 - 242
    10/01/2013 Authors: Laval J; Ingersoll S; Preininger M; Brown M; Tangpricha V; Tirouvanziam R
  • Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression.
    J Immunol Volume: 190 Page(s): 6043 - 6050
    06/15/2013 Authors: Laval J; Touhami J; Herzenberg LA; Conrad C; Taylor N; Battini J-L; Sitbon M; Tirouvanziam R
  • The long-term impact of early adversity on late-life psychiatric disorders.
    Curr Psychiatry Rep Volume: 15 Page(s): 352
    04/01/2013 Authors: Gershon A; Sudheimer K; Tirouvanziam R; Williams LM; O'Hara R
  • Blood basophils from cystic fibrosis patients with allergic bronchopulmonary aspergillosis are primed and hyper-responsive to stimulation by aspergillus allergens.
    J Cyst Fibros Volume: 11 Page(s): 502 - 510
    12/01/2012 Authors: Gernez Y; Dunn CE; Everson C; Mitsunaga E; Gudiputi L; Krasinska K; Davies ZA; Herzenberg LA; Tirouvanziam R; Moss RB
  • WHY HYPERGLYCEMIA IS BAD-LINK BETWEEN GLUCOSE, OXIDATIVE STRESS & INFLAMMATION
    Volume: 47 Page(s): 159 - 161
    09/01/2012 Authors: Stecenko A; Gibson G; Hansen J; Tirouvanziam R; Ziady AG
  • DIFFERENTIAL EXPRESSION OF THE IMMUNOMODULATORY CLEC12A AND MELANOCORTIN-1 RECEPTORS IN NEUTROPHILS HOMING TO CF AIRWAYS
    Volume: 47 Page(s): 271 - 271
    09/01/2012 Authors: Laval J; Sitbon M; Tirouvanziam R
  • PURE, FACS-SORTED, LIVE NEUTROPHILS FROM CF AIRWAYS DISPLAY MARKED CHANGES IN THEIR TRANSCRIPTIONAL PROFILE, CONSISTENT WITH REPROGRAMMING
    Volume: 47 Page(s): 268 - 268
    09/01/2012 Authors: Preininger M; Diaz D; Tirouvanziam R
  • Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients.
    J Clin Immunol Volume: 32 Page(s): 565 - 573
    06/01/2012 Authors: Gernez Y; Tirouvanziam R; Reshamwala N; Yu G; Weldon BC; Galli SJ; Herzenberg LA; Nadeau KC
  • A randomized controlled pilot trial of oral N-acetylcysteine in children with autism.
    Biol Psychiatry Volume: 71 Page(s): 956 - 961
    06/01/2012 Authors: Hardan AY; Fung LK; Libove RA; Obukhanych TV; Nair S; Herzenberg LA; Frazier TW; Tirouvanziam R
  • Distinct plasma profile of polar neutral amino acids, leucine, and glutamate in children with Autism Spectrum Disorders.
    J Autism Dev Disord Volume: 42 Page(s): 827 - 836
    05/01/2012 Authors: Tirouvanziam R; Obukhanych TV; Laval J; Aronov PA; Libove R; Banerjee AG; Parker KJ; O'Hara R; Herzenberg LA; Herzenberg LA
  • Specific Induction Of CD203c Expression In Blood Basophils Discriminates Between CF patients With Aspergillus Colonization And Those With CF-ABPA
    Volume: 129 Page(s): AB139 - AB139
    02/01/2012 Authors: Gernez Y; Everson C; Mitsunaga E; Dunn C; Herzenberg L; Tirouvanziam R; Moss R
  • Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis.
    J Pediatr Gastroenterol Nutr Volume: 53 Page(s): 40 - 47
    07/01/2011 Authors: Nguyen T; Gernez Y; Fuentebella J; Patel A; Tirouvanziam R; Reshamwala N; Bass D; Berquist WE; Cox KL; Kerner JA
  • METABOLIC CONDITIONING AND REPROGRAMMING ARE HALLMARKS OF NEUTROPHILIC INFLAMMATION IN CYSTIC FIBROSIS
    Volume: 60 Page(s): 78 - 78
    06/01/2011 Authors: Tirouvanziam R; Laval J; Gudiputi L; Touhami J; Battini J-L; Conrad C; Milla C; Moss R; Sitbon M; Herzenberg L
  • Immunoinflammatory Stress Loops in Patients with Autism and Other Chronic Neurological Disorders
    Volume: 69 Page(s): 121S - 121S
    05/01/2011 Authors: Tirouvanziam R
  • Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy.
    Int Arch Allergy Immunol Volume: 154 Page(s): 318 - 327
    01/01/2011 Authors: Gernez Y; Tirouvanziam R; Yu G; Ghosn EEB; Reshamwala N; Nguyen T; Tsai M; Galli SJ; Herzenberg LA; Herzenberg LA
  • PET imaging of cerebral ischemia-induced neuroinflammation in mice using F-18-PBR06
    Volume: 54 Page(s): S319 - S319
    01/01/2011 Authors: Lartey FM; Ahn G-O; Shen B; Cord K-T; Smith T; Chua JY; Rosenblum S; Tirouvanziam R; Palmer T; Guzman R
  • CD203C AND CD63 EXPRESSION IN BLOOD BASOPHILS DISCRIMINATE BETWEEN CF PATIENTS WITH ASPERGILLOSIS COLONIZATION AND THOSE WITH CF-ABPA
    Page(s): 241 - 241
    01/01/2011 Authors: Gemez Y; Tirouvanziam R; Dunn CE; Everson C; Davis ZA; Herzenberg LA; Moss RB
  • A MULTI-CENTER, PHASE IIB, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY OF THE EFFECTS OF N-ACETYLCYSTEINE (NAC) ON REDOX CHANGES AND LUNG INFLAMMATION IN CYSTIC FIBROSIS PATIENTS
    Page(s): 280 - 281
    01/01/2011 Authors: Tirouvanziam R; Lymp J; Thompson V; Chatfield BA; Nicholls D; Clancy JP; Vender R; Egan M; Quittell L; Michelson P
  • METABOLITE PROFILING OF CF AIRWAY FLUID SUGGESTS A ROLE FOR CATECHOLAMINES IN EARLY AND CHRONIC DISEASE
    Page(s): 240 - 240
    01/01/2011 Authors: Gudiputi L; Aronov P; Makam M; Zirbes J; Conrad C; Milla C; Herzenberg L; Moss R; Tirouvanziam R
  • THE GENE MODIFIER OF CF AIRWAY DISEASE, IFRD1, IS UPREGULATED IN CF AIRWAY NEUTROPHILS UPON RECRUITMENT FROM BLOOD AND DELINEATES TWO DISTINCT FUNCTIONAL SUBSETS
    PEDIATRIC PULMONOLOGY Page(s): 260 - 261
    01/01/2011 Authors: Miglianico M; Gudiputi L; Laval J; Conrad CK; Herzenberg L; Tirouvanziam R
  • Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy
    Volume: 65 Page(s): 503 - 503
    06/01/2010 Authors: Gernez Y; Yu G; Ghosn E; Tsai M; Galli S; Herzenberg L; Tirouvanziam R; Nadeau K
  • Neutrophils in chronic inflammatory airway diseases: can we target them and how?
    Eur Respir J Volume: 35 Page(s): 467 - 469
    03/01/2010 Authors: Gernez Y; Tirouvanziam R; Chanez P
  • Human Basophils: New Mechanisms Of Action And Role In Food Allergy
    Volume: 125 Page(s): AB86 - AB86
    02/01/2010 Authors: Gernez Y; Tirouvanziam R; Yu G; Reshamwala N; Tsai M; Galli SJ; Herzenberg LA; Nadeau KC
  • EVIDENCE FOR AIRWAY NEUTROPHIL DYSFUNCTION IN CF NEWBORNS AND INFANTS
    Page(s): 268 - 268
    01/01/2010 Authors: Tirouvanziam R; Zirbes JM; Milla C
  • HALLMARKS OF ANABOLIC REPROGRAMMING IN NEUTROPHILS RECRUITED TO CF AIRWAYS
    Page(s): 269 - 269
    01/01/2010 Authors: Laval J; Miglianico M; Touhami J; Kong R; George T; Conrad C; Herzenberg L; Battini J; Sitbon M; Tirouvanziam R
  • SMALL METABOLITE PROFILING OF AIRWAY FLUID UNCOVERS SPECIFIC ALTERATIONS IN CF
    Page(s): 243 - 243
    01/01/2010 Authors: Tirouvanziam R; Aronov P; Laval J; Makam M; Liu C; Chien A; Herzenberg L; Gronert K; Moss RB
  • Transcription Factors as Disease Indicators in Eosinophilic Esophagitis
    Volume: 135 Page(s): S81 - S82
    01/01/2010 Authors: Nguyen T; Gernez Y; Fuentella J; Patel A; Tirouvanziam R; Reshamwala N; Saper V; Bass D; Berquist W; Kerner J
  • Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs.
    Proc Natl Acad Sci U S A Volume: 106 Page(s): 5779 - 5783
    04/07/2009 Authors: Makam M; Diaz D; Laval J; Gernez Y; Conrad CK; Dunn CE; Davies ZA; Moss RB; Herzenberg LA; Herzenberg LA
  • Cd161 Defines Functional Memory Subset Of Cd4 And Cd8 In Asthma
    Volume: 123 Page(s): S93 - S93
    02/01/2009 Authors: Gernez Y; Atkuri K; Guyen NT; Herzenberg L; Tirouvanziam R; Nadeau K
  • Enhanced Expression of CD66b on Peripheral Blood Granulocytes in Eosinophilic Esophagitis
    Volume: 131 Page(s): S120 - S121
    01/01/2009 Authors: Nguyen T; Gernez Y; Fuentebella J; Patel A; Herzenberg L; Tirouvanziam R; Nadeau K
  • CHASING AFTER THE CF AIRWAY NEUTROPHIL: HIGH-CONTENT FLOW & IMAGE CYTOMETRY REVEAL UNSUSPECTED IMMUNE COMPETENCES
    Page(s): 231 - 232
    01/01/2009 Authors: Laval J; Makam M; Diaz D; Kong R; George T; Tirouvanziam R
  • Immunological and redox biomarkers of neutrophils function in HIV/AIDS disease
    Volume: 6
    01/01/2009 Authors: Emaleu SB; Atkuri K; Tirouvanziam R; Sahaf B; Zolopa A; Herzenberg L; Herzenberg L
  • Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways.
    Proc Natl Acad Sci U S A Volume: 105 Page(s): 4335 - 4339
    03/18/2008 Authors: Tirouvanziam R; Gernez Y; Conrad CK; Moss RB; Schrijver I; Dunn CE; Davies ZA; Herzenberg LA; Herzenberg LA
  • Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids.
    J Allergy Clin Immunol Volume: 120 Page(s): 1441 - 1448
    12/01/2007 Authors: Gernez Y; Tirouvanziam R; Nguyen KD; Herzenberg LA; Krensky AM; Nadeau KC
  • [Phospho-FACS: a powerful tool for exploring intracellular transduction cascades].
    Rev Mal Respir Volume: 24 Page(s): 955 - 964
    10/01/2007 Authors: Gernez Y; Herzenberg LA; Herzenberg LA; Tirouvanziam R
  • Modern flow cytometry: a practical approach.
    Clin Lab Med Volume: 27 Page(s): 453 - v
    09/01/2007 Authors: Tung JW; Heydari K; Tirouvanziam R; Sahaf B; Parks DR; Herzenberg LA; Herzenberg LA
  • A real-life view of imflammation in CF: Novel functional assays for immune cell analysis
    Page(s): 185 - 186
    01/01/2007 Authors: Tirouvanziam R
  • Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis.
    Drug News Perspect Volume: 19 Page(s): 609 - 614
    12/01/2006 Authors: Tirouvanziam R
  • High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis.
    Proc Natl Acad Sci U S A Volume: 103 Page(s): 4628 - 4633
    03/21/2006 Authors: Tirouvanziam R; Conrad CK; Bottiglieri T; Herzenberg LA; Moss RB; Herzenberg LA
  • Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes.
    Genetics Volume: 169 Page(s): 215 - 229
    01/01/2005 Authors: Davidson CJ; Tirouvanziam R; Herzenberg LA; Lipsick JS
  • Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes.
    Proc Natl Acad Sci U S A Volume: 101 Page(s): 2912 - 2917
    03/02/2004 Authors: Tirouvanziam R; Davidson CJ; Lipsick JS; Herzenberg LA
  • Primary inflammation in human cystic fibrosis small airways.
    Am J Physiol Lung Cell Mol Physiol Volume: 283 Page(s): L445 - L451
    08/01/2002 Authors: Tirouvanziam R; Khazaal I; Pault B
  • Ex vivo development of functional human lymph node and bronchus-associated lymphoid tissue.
    Blood Volume: 99 Page(s): 2483 - 2489
    04/01/2002 Authors: Tirouvanziam R; Khazaal I; N'Sond V; Peyrat M-A; Lim A; de Bentzmann S; Fourni JJ; Bonneville M; Pault B
  • Inflammation and infection in naive human cystic fibrosis airway grafts.
    Am J Respir Cell Mol Biol Volume: 23 Page(s): 121 - 127
    08/01/2000 Authors: Tirouvanziam R; de Bentzmann S; Hubeau C; Hinnrasky J; Jacquot J; Pault B; Puchelle E
  • Epithelial stem cell-mediated development of the human respiratory mucosa in SCID mice.
    J Cell Sci Volume: 113 ( Pt 5) Page(s): 767 - 778
    03/01/2000 Authors: Delplanque A; Coraux C; Tirouvanziam R; Khazaal I; Puchelle E; Ambros P; Gaillard D; Pault B
  • A surrogate human mucosal lymphoid sytem in the SCID mouse.
    Volume: 94 Page(s): 59B - 59B
    11/15/1999 Authors: Tirouvanziam R; Khazaal I; De Bentzmann S; Lim A; Bonneville M; Peault B
  • Ion composition and rheology of airway liquid from cystic fibrosis fetal tracheal xenografts.
    Am J Respir Cell Mol Biol Volume: 20 Page(s): 605 - 611
    04/01/1999 Authors: Baconnais S; Tirouvanziam R; Zahm JM; de Bentzmann S; Pault B; Balossier G; Puchelle E
  • [Cystic fibrosis: a complex disease and a paradigm for biomedical research].
    J Soc Biol Volume: 193 Page(s): 189 - 209
    01/01/1999 Authors: Tirouvanziam R
  • Bioelectric properties of human cystic fibrosis and non-cystic fibrosis fetal tracheal xenografts in SCID mice.
    Am J Physiol Volume: 274 Page(s): C875 - C882
    04/01/1998 Authors: Tirouvanziam R; Desternes M; Saari A; Puchelle E; Pault B; Chinet T
  • X-ray microanalysis and rheological properties of airway surface liquid
    Page(s): 329 - 330
    01/01/1998 Authors: Baconnais S; Tirouvanziam R; Zahm JM; de Bentzmann S; Peault B; Bonhomme P; Balossier G; Puchelle E
  • Gene transfer to human respiratory airways developed in SCID mice.
    Biologicals Volume: 23 Page(s): 17 - 19
    03/01/1995 Authors: Tirouvanziam R; Pault B
  • Gene transfer to human fetal pulmonary tissue developed in immunodeficient SCID mice.
    Hum Gene Ther Volume: 5 Page(s): 1131 - 1137
    09/01/1994 Authors: Pault B; Tirouvanziam R; Sombardier MN; Chen S; Perricaudet M; Gaillard D
Read more publications Fewer publications
Directory
  • Faculty Profiles
Emory University Homepage

Contact & Location

Emory University School of Medicine
100 Woodruff Circle
Atlanta, GA  30322 USA
  • Contact Us
  • Maps & Directions
  • Careers

Information For

  • Alumni
  • Faculty & Staff
  • Patients
  • Residents & Fellows
  • Students
Support the School of Medicine School of Medicine Intranet
facebook facebook twitter twitter linkedin linkedin instagram instagram youtube youtube
© 2025 Emory University
  • Privacy Policy
  • Emergency Information
  • EEO Employer-Disability/Veteran Statements