Raymond Schinazi PhD, DSc
Academic Appointment
- Voluntary Professor of Medicine, University of Miami School of Medicine
- Professor of Pediatrics, Department of Pediatrics, Atlanta
- Professor & Director, Department of Pediatrics, Emory University School of Medicine
- Adjunct Associate Professor, Department of Chemistry, Georgia State University
- Affiliate Scientist, Division of Pathobiology and Immunobiology, Emory University Emory National Primate Center
- Vision Research Faculty, Department of Ophthalmology, Emory University School of Medicine
Education
Degrees
- BS from University of Bath
- PhD from University of Bath
Research
Publications
-
Combating yellow fever virus with 7-deaza-7-fluoro-2'-C-methyladenosine.
Antimicrob Agents Chemother Volume: 69 Page(s): e0188924
05/07/2025 Authors: LeCher JC; Costa VV; Rust LN; Bassit LC; Patel D; Rezaei S; Moua J; Santos FRDS; Goncalves MR; Queroz-Junior CM -
Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome.
Sci Adv Volume: 11 Page(s): eadi9885
03/21/2025 Authors: Hargarten JC; Ssebambulidde K; Anjum SH; Vaughan MJ; Xu J; Ganguly A; Dulek B; Otaizo-Carrasquero F; Song B; Tao S -
Reader comment on: "Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir".
Toxicol Sci Volume: 204 Page(s): 116 - 117
03/01/2025 Authors: Frederick CB; Schinazi RF; Swanstrom R -
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
J Med Chem Volume: 67 Page(s): 21126 - 21142
12/12/2024 Authors: Vendeville S; Amblard F; Bassit L; Beigelman LN; Blatt LM; Chen X; Chou L; Kum DB; Chanda S; Deval J -
Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization.
Virology Volume: 600 Page(s): 110255
12/01/2024 Authors: Oo A; Chen Z; Cao D; Cho Y-J; Liang B; Schinazi RF; Kim B -
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
mBio Volume: 15 Page(s): e0046524
11/13/2024 Authors: Dinh T; Tber Z; Rey JS; Mengshetti S; Annamalai AS; Haney R; Briganti L; Amblard F; Fuchs JR; Cherepanov P -
Cannabinoid-Inspired Inhibitors of the SARS-CoV-2 Coronavirus 2'-O-Methyltransferase (2'-O-MTase) Non-Structural Protein (Nsp10-16).
Molecules Volume: 29
10/28/2024 Authors: Benjamin MM; Hanna GS; Dickinson CF; Choo Y-M; Wang X; Downs-Bowen JA; De R; McBrayer TR; Schinazi RF; Nielson SE -
Protocol for the creation and characterization of SARS-CoV-2 variant testing panels using remnant clinical samples for diagnostic assay testing.
STAR Protoc Volume: 5 Page(s): 103146
09/20/2024 Authors: Bassit L; Bowers HB; Greenleaf M; Sabino C; Lai E; Yu G; Piantadosi A; Wang E; O'Sick W; McLendon K -
N4-Hydroxycytidine/molnupiravir inhibits RNA virus-induced encephalitis by producing less fit mutated viruses.
PLoS Pathog Volume: 20 Page(s): e1012574
09/01/2024 Authors: Ojha D; Hill CS; Zhou S; Evans A; Leung JM; Schneider CA; Amblard F; Woods TA; Schinazi RF; Baric RS -
Development of robust antiviral assays using relevant apical-out human airway organoids.
bioRxiv
07/12/2024 Authors: Lee J-H; LeCher JC; Parigoris E; Shinagawa N; Sentosa J; Manfredi C; Goh SL; De R; Tao S; Zandi K -
Direct Synthesis of Aryloxy Phosphonamidate Nucleotide Prodrugs Using the Cross Metathesis Assisted by Ultrasonic Irradiation.
Org Lett Volume: 26 Page(s): 4841 - 4846
06/14/2024 Authors: Choi SM; Nam YE; An YJ; Choi ER; Park H; Schinazi RF; Cho JH -
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Blood Volume: 143 Page(s): 1953 - 1964
05/09/2024 Authors: Abdelrazak Morsy MH; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B -
Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections.
Viruses Volume: 16
04/22/2024 Authors: Hurwitz SJ; De R; LeCher JC; Downs-Bowen JA; Goh SL; Zandi K; McBrayer T; Amblard F; Patel D; Kohler JJ -
Biophysics-Guided Lead Discovery of HBV Capsid Assembly Modifiers.
ACS Infect Dis Volume: 10 Page(s): 1162 - 1173
04/12/2024 Authors: Fan Z; Pavlova A; Jenkins MC; Bassit L; Salman M; Lynch DL; Patel D; Korablyov M; Finn MG; Schinazi RF -
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
Eur J Med Chem Volume: 268 Page(s): 116263
03/15/2024 Authors: Amblard F; LeCher JC; De R; Zhou S; Liu P; Goh SL; Tao S; Patel D; Downs-Bowen J; Zandi K -
Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV-2 2'-O-Methyltransferase.
J Nat Prod Volume: 87 Page(s): 217 - 227
02/23/2024 Authors: Hanna GS; Benjamin MM; Choo Y-M; De R; Schinazi RF; Nielson SE; Hevel JM; Hamann MT -
Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
Nucleic Acids Res Volume: 52 Page(s): 1207 - 1225
02/09/2024 Authors: Xu P; Yang T; Kundnani DL; Sun M; Marsili S; Gombolay AL; Jeon Y; Newnam G; Balachander S; Bazzani V -
The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir.
bioRxiv
01/26/2024 Authors: Dinh T; Tber Z; Rey JS; Mengshetti S; Annamalai AS; Haney R; Briganti L; Amblard F; Fuchs JR; Cherepanov P -
SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
Blood Volume: 143 Page(s): 1953 - 1964
01/18/2024 Authors: Morsy MHA; Lilienthal I; Lord M; Merrien M; Wasik AM; Sureda-Gmez M; Amador V; Johansson HJ; Lehti J; Garcia-Torre B -
Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
Bioorg Chem Volume: 141 Page(s): 106923
12/01/2023 Authors: Amblard F; Chen Z; Wiseman J; Zhou S; Liu P; Salman M; Verma K; Azadi N; Downs-Bowen J; Tao S -
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutires syndrome SAMHD1 dNTPase ortholog.
J Biol Chem Volume: 299 Page(s): 105148
09/01/2023 Authors: Maehigashi T; Lim C; Wade LR; Bowen NE; Knecht KM; Alvarez NN; Kelly WG; Schinazi RF; Kim D-H; Xiong Y -
N4 -Hydroxycytidine/Molnupiravir Inhibits RNA-Virus Induced Encephalitis by Producing Mutated Viruses with Reduced Fitness.
bioRxiv
08/23/2023 Authors: Ojha D; Hill CS; Zhou S; Evans AB; Leung JM; Lewis CS; Amblard F; Schinazi RF; Baric RS; Peterson KE -
Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages.
J Biol Chem Volume: 299 Page(s): 104984
08/01/2023 Authors: Bowen NE; Tao S; Cho Y-J; Schinazi RF; Kim B -
Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies.
Vaccine Volume: 41 Page(s): 3171 - 3177
05/11/2023 Authors: Roper RL; Garzino-Demo A; Del Rio C; Brchot C; Gallo R; Hall W; Esparza J; Reitz M; Schinazi RF; Parrington M -
TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques.
Nat Commun Volume: 14 Page(s): 1914
04/06/2023 Authors: Upadhyay AA; Viox EG; Hoang TN; Boddapati AK; Pino M; Lee MY-H; Corry J; Strongin Z; Cowan DA; Beagle EN -
Synthesis of 4'-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents.
Viruses Volume: 15
02/16/2023 Authors: Biteau NG; Amichai SA; Azadi N; De R; Downs-Bowen J; Lecher JC; MacBrayer T; Schinazi RF; Amblard F -
Botanical inhibitors of SARS-CoV-2 viral entry: a phylogenetic perspective.
Sci Rep Volume: 13 Page(s): 1244
01/23/2023 Authors: Risener CJ; Woo S; Samarakoon T; Caputo M; Edwards E; Klepzig K; Applequist W; Zandi K; Goh SL; Downs-Bowen JA -
The premise of capsid assembly modulators towards eliminating HBV persistence.
Expert Opin Drug Discov Volume: 18 Page(s): 1031 - 1041
01/01/2023 Authors: Bassit L; Amblard F; Patel D; Biteau N; Chen Z; Kasthuri M; Zhou S; Schinazi RF -
Lessons Learned from In-Person Conferences in the Times of COVID-19.
Int J Environ Res Public Health Volume: 20
12/28/2022 Authors: Ehteshami M; Edgar CL; Delgado Ayala LY; Hagan M; Martin GS; Lam W; Schinazi RF -
Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial.
J Intern Med Volume: 292 Page(s): 925 - 940
12/01/2022 Authors: Jdersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzn S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G -
Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice.
Microorganisms Volume: 10
10/22/2022 Authors: LeCher JC; Zandi K; Costa VV; Amblard F; Tao S; Patel D; Lee S; da Silva Santos FR; Goncalves MR; Queroz-Junior CM -
HIV nucleoside reverse transcriptase inhibitors.
Eur J Med Chem Volume: 240 Page(s): 114554
10/05/2022 Authors: Amblard F; Patel D; Michailidis E; Coats SJ; Kasthuri M; Biteau N; Tber Z; Ehteshami M; Schinazi RF -
Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
Pharmaceuticals (Basel) Volume: 15
09/14/2022 Authors: Amblard F; LeCher JC; De R; Goh SL; Li C; Kasthuri M; Biteau N; Zhou L; Tber Z; Downs-Bowen J -
Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2.
Molecules Volume: 27
08/24/2022 Authors: Patel D; Ono SK; Bassit L; Verma K; Amblard F; Schinazi RF -
The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach.
Eur J Pharm Sci Volume: 175 Page(s): 106220
08/01/2022 Authors: Mirza MU; Alanko I; Vanmeert M; Muzzarelli KM; Salo-Ahen OMH; Abdullah I; Kovari IA; Claes S; De Jonghe S; Schols D -
Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes.
Cell Rep Volume: 39 Page(s): 110945
06/14/2022 Authors: Dobosh B; Zandi K; Giraldo DM; Goh SL; Musall K; Aldeco M; LeCher J; Giacalone VD; Yang J; Eddins DJ -
In silico design of a novel nucleotide antiviral agent by free energy perturbation.
Chem Biol Drug Des Volume: 99 Page(s): 801 - 815
06/01/2022 Authors: Patel D; Cox BD; Kasthuri M; Mengshetti S; Bassit L; Verma K; Ollinger-Russell O; Amblard F; Schinazi RF -
Identification of Botanical Viral Entry Inhibitors for SARS-CoV-2.
FASEB J Volume: 36 Suppl 1
05/01/2022 Authors: Risener CJ; Woo S; Samarakoon T; Caputo M; Edwards E; Zandi K; Goh SL; Downs-Bowen JA; Schinazi RF; Quave CL -
The best backbone for HIV prevention, treatment, and elimination: Emtricitabine+tenofovir.
Antivir Ther Volume: 27 Page(s): 13596535211067599
04/01/2022 Authors: Schinazi RF; Patel D; Ehteshami M -
The Mechanism of Action of Hepatitis B Virus Capsid Assembly Modulators Can Be Predicted from Binding to Early Assembly Intermediates.
J Med Chem Volume: 65 Page(s): 4854 - 4864
03/24/2022 Authors: Pavlova A; Bassit L; Cox BD; Korablyov M; Chipot C; Patel D; Lynch DL; Amblard F; Schinazi RF; Gumbart JC -
Assessment of the Abbott BinaxNOW SARS-CoV-2 rapid antigen test against viral variants of concern.
iScience Volume: 25 Page(s): 103968
03/18/2022 Authors: Rao A; Bassit L; Lin J; Verma K; Bowers HB; Pachura K; Greenleaf M; Sullivan J; Lai E; Creager RS -
Elimination of Aicardi-Goutires syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication.
J Biol Chem Volume: 298 Page(s): 101635
03/01/2022 Authors: Oo A; Zandi K; Shepard C; Bassit LC; Musall K; Goh SL; Cho Y-J; Kim D-H; Schinazi RF; Kim B -
Cognitively Based Compassion Training for HIV Immune Nonresponders-An Attention-Placebo Randomized Controlled Trial.
J Acquir Immune Defic Syndr Volume: 89 Page(s): 340 - 348
03/01/2022 Authors: Titanji BK; Tejani M; Farber EW; Mehta CC; Pace TW; Meagley K; Gavegnano C; Harrison T; Kokubun CW; Negi SD -
Inactivation of SARS-CoV-2 and COVID-19 Patient Samples for Contemporary Immunology and Metabolomics Studies.
Immunohorizons Volume: 6 Page(s): 144 - 155
02/16/2022 Authors: Eddins DJ; Bassit LC; Chandler JD; Haddad NS; Musall KL; Yang J; Kosters A; Dobosh BS; Hernndez MR; Ramonell RP -
Lethal mutagenesis as an antiviral strategy.
Science Volume: 375 Page(s): 497 - 498
02/04/2022 Authors: Swanstrom R; Schinazi RF -
GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition.
Viruses Volume: 14
01/12/2022 Authors: Bestion E; Zandi K; Belouzard S; Andreani J; Lepidi H; Novello M; Rouquairol C; Baudoin J-P; Rachid M; La Scola B -
Diastereoselective Synthesis of 2'-Dihalopyrimidine Ribonucleoside Inhibitors of Hepatitis C Virus Replication.
ACS Omega Volume: 7 Page(s): 1452 - 1461
01/11/2022 Authors: Zhou L; Zhang H; Li C; De Schutter C; Sari O; Mengshetti S; Zhou S; Kasthuri M; Coats SJ; Schinazi RF -
Randomized Trial of Ruxolitinib in Antiretroviral-Treated Adults With Human Immunodeficiency Virus.
Clin Infect Dis Volume: 74 Page(s): 95 - 104
01/07/2022 Authors: Marconi VC; Moser C; Gavegnano C; Deeks SG; Lederman MM; Overton ET; Tsibris A; Hunt PW; Kantor A; Sekaly R-P -
An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza.
Pathog Immun Volume: 7 Page(s): 104 - 121
01/01/2022 Authors: Merigeon EY; Yang D; Ihms EA; Bassit LC; Fitzpatrick EA; Jonsson CB; Schinazi RF; Block DS; Olsen HS -
Reply to Jorgensen, et al.
Clin Infect Dis Volume: 73 Page(s): e3978 - e3979
12/06/2021 Authors: Titanji BK; Farley MM; Schinazi RF; Marconi VC -
Response to Correspondence: Baricitinib: Impact on Coronavirus Disease 2019 (COVID-19) Coagulopathy? Jorgensen et al.
Clin Infect Dis Volume: 73 Page(s): e3980 - e3981
12/06/2021 Authors: Titanji BK; Farley MM; Schinazi RF; Marconi VC -
Pharmacokinetics of Ruxolitinib in HIV Suppressed Individuals on Antiretroviral Agent Therapy from the ACTG A5336 Study.
J Clin Pharmacol Volume: 61 Page(s): 1555 - 1566
12/01/2021 Authors: Hurwitz SJ; Tao S; Gavegnano C; Jiang Y; Tressler RL; Tsibris A; Del Rio C; Overton ET; Lederman MM; Kantor A -
Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses.
J Nat Prod Volume: 84 Page(s): 3001 - 3007
11/26/2021 Authors: Hanna GS; Choo Y-M; Harbit R; Paeth H; Wilde S; Mackle J; Verga J-U; Wolf BJ; Thomas OP; Croot P -
Single-Amplicon Multiplex Real-Time Reverse Transcription-PCR with Tiled Probes To Detect SARS-CoV-2 spike Mutations Associated with Variants of Concern.
J Clin Microbiol Volume: 59 Page(s): e0144621
11/18/2021 Authors: Babiker A; Immergluck K; Stampfer SD; Rao A; Bassit L; Su M; Nguyen V; Stittleburg V; Ingersoll JM; Bradley HL -
Design, antihuman immunodeficiency activity and molecular docking studies of synthesized 2-aryl and 2-pyrimidinyl pyrrolidines.
Mol Divers Volume: 25 Page(s): 2045 - 2052
11/01/2021 Authors: Gasparyan SP; Martirosyan AH; Alexanyan MV; Harutyunyan GK; Chilingaryan GV; Coats S; Schinazi RF -
Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens.
Emerg Infect Dis Volume: 27 Page(s): 2887 - 2891
11/01/2021 Authors: Immergluck K; Gonzalez MD; Frediani JK; Levy JM; Figueroa J; Wood A; Rogers BB; O'Neal J; Elias-Marcellin R; Suessmith A -
Reply to Troth et al.
J Infect Dis Volume: 224 Page(s): 1443 - 1444
10/28/2021 Authors: Zhou S; Hill CS; Woodburn BMD; Schinazi RF; Swanstrom R -
TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques.
bioRxiv
10/05/2021 Authors: Upadhyay AA; Hoang TN; Pino M; Boddapati AK; Viox EG; Lee MYH; Corry J; Strongin Z; Cowan DA; Beagle EN -
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
J Biol Chem Volume: 297 Page(s): 101170
10/01/2021 Authors: Bowen NE; Temple J; Shepard C; Oo A; Arizaga F; Kapoor-Vazirani P; Persaud M; Yu CH; Kim D-H; Schinazi RF -
-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells.
J Infect Dis Volume: 224 Page(s): 415 - 419
08/02/2021 Authors: Zhou S; Hill CS; Sarkar S; Tse LV; Woodburn BMD; Schinazi RF; Sheahan TP; Baric RS; Heise MT; Swanstrom R -
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration.
Sci Rep Volume: 11 Page(s): 14604
07/16/2021 Authors: Frediani JK; Levy JM; Rao A; Bassit L; Figueroa J; Vos MB; Wood A; Jerris R; Van Leung-Pineda; Gonzalez MD -
Capsid assembly modulator ALG-000111 and its prodrug ALG-000286 display excellent in vitro and in vivo antiviral activity
Volume: 75 Page(s): S744 - S745
07/01/2021 Authors: Debing Y; Kum DB; Liu C; Deval J; Vanrusselt H; Sanchez AA; Zhang Q; Mukherjee S; Misner D; Chanda S -
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template.
J Biol Chem Volume: 297 Page(s): 100770
07/01/2021 Authors: Gordon CJ; Tchesnokov EP; Schinazi RF; Gtte M -
Non-alcoholic fatty liver disease is a risk factor for occurrence of hepatocellular carcinoma after sustained virologic response in chronic hepatitis C patients: A prospective four-years follow-up study.
Metabol Open Volume: 10 Page(s): 100090
06/01/2021 Authors: Ji D; Chen G-F; Niu X-X; Zhang M; Wang C; Shao Q; Wu V; Wang Y; Cheng G; Hurwitz SJ -
The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change.
IEEE Open J Eng Med Biol Volume: 2 Page(s): 142 - 151
04/28/2021 Authors: Nehl E; Heilman S; Ku D; Gottfried D; Farmer S; Mannino R; Tyburski E; Sullivan J; Suessmith A; Bassit L -
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
Microorganisms Volume: 9
04/22/2021 Authors: Zandi K; Musall K; Oo A; Cao D; Liang B; Hassandarvish P; Lan S; Slack RL; Kirby KA; Bassit L -
Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 2019.
Clin Infect Dis Volume: 72 Page(s): 1247 - 1250
04/08/2021 Authors: Titanji BK; Farley MM; Mehta A; Connor-Schuler R; Moanna A; Cribbs SK; O'Shea J; DeSilva K; Chan B; Edwards A -
Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(E)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs.
Molecules Volume: 26
03/09/2021 Authors: Abuduaini T; Roy V; Marlet J; Gaudy-Graffin C; Brand D; Baronti C; Touret F; Coutard B; McBrayer TR; Schinazi RF -
Covid-19 will not "magically disappear": Why access to widespread testing is paramount.
Am J Hematol Volume: 96 Page(s): 174 - 178
02/01/2021 Authors: George PE; Stokes CL; Bassit LC; Chahroudi A; Figueroa J; Griffiths MA; Heilman S; Ku DN; Nehl EJ; Leong T -
Discovery and structure activity relationship of glyoxamide derivatives as anti-hepatitis B virus agents.
Bioorg Med Chem Volume: 31 Page(s): 115952
02/01/2021 Authors: Amblard F; Boucle S; Bassit L; Chen Z; Sari O; Cox B; Verma K; Ozturk T; Ollinger-Russell O; Schinazi RF -
Disproportionate presence of adenosine in mitochondrial and chloroplast DNA of Chlamydomonas reinhardtii.
iScience Volume: 24 Page(s): 102005
01/22/2021 Authors: El-Sayed WMM; Gombolay AL; Xu P; Yang T; Jeon Y; Balachander S; Newnam G; Tao S; Bowen NE; Brna T -
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Cell Volume: 184 Page(s): 460 - 475.e21
01/21/2021 Authors: Hoang TN; Pino M; Boddapati AK; Viox EG; Starke CE; Upadhyay AA; Gumber S; Nekorchuk M; Busman-Sahay K; Strongin Z -
Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator.
Viruses Volume: 13
01/15/2021 Authors: Hurwitz SJ; McBrearty N; Arzumanyan A; Bichenkov E; Tao S; Bassit L; Chen Z; Kohler JJ; Amblard F; Feitelson MA -
Moving Fast Toward Hepatitis B Virus Elimination.
Adv Exp Med Biol Volume: 1322 Page(s): 115 - 138
01/01/2021 Authors: Bassit L; Ono SK; Schinazi RF -
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
Curr Res Pharmacol Drug Discov Volume: 2 Page(s): 100045
01/01/2021 Authors: Tao S; Zandi K; Bassit L; Ong YT; Verma K; Liu P; Downs-Bowen JA; McBrayer T; LeCher JC; Kohler JJ -
RADx Variant Task Force Program for Assessing the Impact of Variants on SARS-CoV-2 Molecular and Antigen Tests.
IEEE Open J Eng Med Biol Volume: 2 Page(s): 286 - 290
01/01/2021 Authors: Creager R; Blackwood J; Pribyl T; Bassit L; Rao A; Greenleaf M; Frank F; Lam W; Ortlund E; Schinazi R -
The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency.
Front Immunol Volume: 12 Page(s): 720697
01/01/2021 Authors: de Armas LR; Gavegnano C; Pallikkuth S; Rinaldi S; Pan L; Battivelli E; Verdin E; Younis RT; Pahwa R; Williams SL -
COVID-19: Discovery, diagnostics and drug development.
J Hepatol Volume: 74 Page(s): 168 - 184
01/01/2021 Authors: Asselah T; Durantel D; Pasmant E; Lau G; Schinazi RF -
The case for simplifying and using absolute targets for viral hepatitis elimination goals.
J Viral Hepat Volume: 28 Page(s): 12 - 19
01/01/2021 Authors: Polaris Observatory Collaborators -
Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase.
J Chem Inf Model Volume: 60 Page(s): 6566 - 6578
12/28/2020 Authors: Freedman H; Kundu J; Tchesnokov EP; Law JLM; Nieman JA; Schinazi RF; Tyrrell DL; Gotte M; Houghton M -
Repurposing Nucleoside Analogs for Human Coronaviruses.
Antimicrob Agents Chemother Volume: 65
12/16/2020 Authors: Zandi K; Amblard F; Musall K; Downs-Bowen J; Kleinbard R; Oo A; Cao D; Liang B; Russell OO; McBrayer T -
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.
J Biol Chem Volume: 295 Page(s): 16975 - 16986
12/11/2020 Authors: Coggins SA; Kim D-H; Schinazi RF; Desrosier RC; Kim B -
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.
J Biol Chem Volume: 295 Page(s): 16975 - 16986
12/11/2020 Authors: Coggins SA; Kim D-H; Schinazi RF; Desrosier RC; Kim B -
Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020.
Emerg Infect Dis Volume: 26 Page(s): 2974 - 2978
12/01/2020 Authors: Hu WT; Howell JC; Ozturk T; Benameur K; Bassit LC; Ramonell R; Cashman KS; Pirmohammed S; Roback JD; Marconi VC -
Novel method to quantify phenotypic markers of HIV-associated neurocognitive disorder in a murine SCID model.
J Neurovirol Volume: 26 Page(s): 838 - 845
12/01/2020 Authors: Gavegnano C; Haile W; Koneru R; Hurwitz SJ; Kohler JJ; Tyor WR; Schinazi RF -
Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance.
Molecules Volume: 25
10/21/2020 Authors: Bertoletti N; Chan AH; Schinazi RF; Anderson KS -
GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition.
bioRxiv
10/06/2020 Authors: Halfon P; Bestion E; Zandi K; Andreani J; Baudoin J-P; La Scola B; Mege J-L; Mezouar S; Schinazi RF -
Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery.
J Biol Chem Volume: 295 Page(s): 13432 - 13443
09/25/2020 Authors: Coggins SA; Mahboubi B; Schinazi RF; Kim B -
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
bioRxiv
09/16/2020 Authors: Hoang TN; Pino M; Boddapati AK; Viox EG; Starke CE; Upadhyay AA; Gumber S; Busman-Sahay K; Strongin Z; Harper JL -
Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122.
Gastroenterology Volume: 159 Page(s): 999 - 1014.e9
09/01/2020 Authors: Chai C; Cox B; Yaish D; Gross D; Rosenberg N; Amblard F; Shemuelian Z; Gefen M; Korach A; Tirosh O -
Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020.
Emerg Infect Dis Volume: 26 Page(s): 2016 - 2021
09/01/2020 Authors: Benameur K; Agarwal A; Auld SC; Butters MP; Webster AS; Ozturk T; Howell JC; Bassit LC; Velasquez A; Schinazi RF -
Erratum for Amblard et al., "Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice".
Antimicrob Agents Chemother Volume: 64
08/20/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O -
7-Deaza-7-fluoro-2'-C-methyladenosine inhibits Zika virus infection and viral-induced neuroinflammation.
Antiviral Res Volume: 180 Page(s): 104855
08/01/2020 Authors: Del Sarto JL; Rocha RDPF; Bassit L; Olmo IG; Valiate B; Queiroz-Junior CM; Pedrosa CDSG; Ribeiro FM; Guimares MZ; Rehen S -
Novel cell culture 3D model for HBV/HIV co-infection and antiviral evaluation
Volume: 73 Page(s): S871 - S872
08/01/2020 Authors: Bassit L; Gavegnano C; Verma K; Kleinbard R; Kohler J; Mead J; Schinazi RF -
Multivariant surface quasispecies in a hepatitis B virus chronically infected individual with concomitant and continually positive surface antigen and anti-HBS biomarkers
Volume: 73 Page(s): S847 - S848
08/01/2020 Authors: Ono SK; Craig J; Bassit L; Abreu R; Gonzalez D; Carrilho FJ; Schinazi RF -
Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine.
Nat Commun Volume: 11 Page(s): 2447
05/15/2020 Authors: Balachander S; Gombolay AL; Yang T; Xu P; Newnam G; Keskin H; El-Sayed WMM; Bryksin AV; Tao S; Bowen NE -
Cross-sectional IgM and IgG profiles in SARS-CoV-2 infection.
medRxiv
05/14/2020 Authors: Ozturk T; Howell JC; Benameur K; Ramonell R; Cashman KS; Pirmohammed S; Bassit LC; Roback JD; Marconi VC; Schinazi RF -
Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
J Virol Volume: 94
03/31/2020 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B -
SAMHD1 Functions and Human Diseases.
Viruses Volume: 12
03/31/2020 Authors: Coggins SA; Mahboubi B; Schinazi RF; Kim B -
Synthesis of 4'-Substituted-2'-Deoxy-2'--Fluoro Nucleoside Analogs as Potential Antiviral Agents.
Molecules Volume: 25
03/11/2020 Authors: Kasthuri M; Li C; Verma K; Russell OO; Dickson L; McCormick L; Bassit L; Amblard F; Schinazi RF -
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
EMBO Mol Med Volume: 12 Page(s): e10419
03/06/2020 Authors: Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CB; Sandhow L; Kutzner J; Hed Myrberg I; Bunten SS; Axelsson H; Zhang SM -
Disentangling the lifespans of hepatitis C virus-infected cells and intracellular vRNA replication-complexes during direct-acting anti-viral therapy.
J Viral Hepat Volume: 27 Page(s): 261 - 269
03/01/2020 Authors: Cardozo EF; Ji D; Lau G; Schinazi RF; Chen G-F; Ribeiro RM; Perelson AS -
Potent in vitro activity of -D-4'-chloromethyl-2'-deoxy-2'-fluorocytidine against Nipah virus.
Antiviral Res Volume: 175 Page(s): 104712
03/01/2020 Authors: Lo MK; Amblard F; Flint M; Chatterjee P; Kasthuri M; Li C; Russell O; Verma K; Bassit L; Schinazi RF -
Targeting Inflammation to Reduce Atherosclerotic Cardiovascular Risk in People With HIV Infection.
J Am Heart Assoc Volume: 9 Page(s): e014873
02/04/2020 Authors: Titanji B; Gavegnano C; Hsue P; Schinazi R; Marconi VC -
Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.
Antimicrob Agents Chemother Volume: 64
01/27/2020 Authors: Amblard F; Boucle S; Bassit L; Cox B; Sari O; Tao S; Chen Z; Ozturk T; Verma K; Russell O -
Viral protein X reduces the incorporation of mutagenic noncanonical rNTPs during lentivirus reverse transcription in macrophages.
J Biol Chem Volume: 295 Page(s): 657 - 666
01/10/2020 Authors: Oo A; Kim D-H; Schinazi RF; Kim B -
Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.
Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 671 - 687
01/01/2020 Authors: Cho JH; Bassit LC; Amblard F; Schinazi RF -
Intracellular metabolism and potential cardiotoxicity of a -D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.
Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 204 - 224
01/01/2020 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Ehteshami M; Jiang Y; Amblard F; Coats SJ -
Novel 1'-homo-N-2'-deoxy--nucleosides: synthesis, characterization and biological activity.
RSC Adv Volume: 10 Page(s): 15815 - 15824
01/01/2020 Authors: Carnero A; Martn-Nieves V; Sanghvi YS; Russel OO; Bassit L; Schinazi RF; Fernndez S; Ferrero M -
Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus.
Viruses Volume: 11
11/08/2019 Authors: Liu D; Tedbury PR; Lan S; Huber AD; Puray-Chavez MN; Ji J; Michailidis E; Saeed M; Ndongwe TP; Bassit LC -
Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation.
Virology Volume: 537 Page(s): 36 - 44
11/01/2019 Authors: Coggins SA; Holler JM; Kimata JT; Kim D-H; Schinazi RF; Kim B -
Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages.
Retrovirology Volume: 16 Page(s): 29
10/26/2019 Authors: Shepard C; Xu J; Holler J; Kim D-H; Mansky LM; Schinazi RF; Kim B -
Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.
Bioorg Med Chem Lett Volume: 29 Page(s): 126639
10/15/2019 Authors: Zhang H; Zhou L; Amichai S; Zandi K; Cox B; Schinazi R; Amblard F -
PRECLINICAL ASSESSMENT OF A NOVEL CAPSID ASSEMBLY MODULATOR, ALG-001075, DEMONSTRATES BEST-IN-CLASS IN VITRO POTENCY AND IN VIVO ANTIVIRAL EFFICACY
Volume: 70 Page(s): 437A - 437A
10/01/2019 Authors: Debing Y; Jekle A; Vendeville S; Stevens SK; Deval J; Zhang Q; Lin T-I; Misner D; Chanda S; Schinazi RF -
Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro.
J Neuroinflammation Volume: 16 Page(s): 182
09/27/2019 Authors: Gavegnano C; Haile WB; Hurwitz S; Tao S; Jiang Y; Schinazi RF; Tyor WR -
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci Volume: 28 Page(s): 1664 - 1675
09/01/2019 Authors: Bertoletti N; Chan AH; Schinazi RF; Yin YW; Anderson KS -
Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
Antimicrob Agents Chemother Volume: 63
09/01/2019 Authors: Zandi K; Amblard F; Amichai S; Bassit L; Tao S; Jiang Y; Zhou L; Ollinger Russell O; Mengshetti S; Schinazi RF -
A global scientific strategy to cure hepatitis B.
Lancet Gastroenterol Hepatol Volume: 4 Page(s): 545 - 558
07/01/2019 Authors: Revill PA; Chisari FV; Block JM; Dandri M; Gehring AJ; Guo H; Hu J; Kramvis A; Lampertico P; Janssen HLA -
Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses.
Antimicrob Agents Chemother Volume: 63
07/01/2019 Authors: Zandi K; Bassit L; Amblard F; Cox BD; Hassandarvish P; Moghaddam E; Yueh A; Libanio Rodrigues GO; Passos I; Costa VV -
Potential drug-drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals.
Int J Infect Dis Volume: 83 Page(s): 98 - 101
06/01/2019 Authors: Mukonzo J; Aklillu E; Marconi V; Schinazi RF -
Inhibiting Mononuclear Phagocyte Functions in a HIV Associated Neurocognitive Disorders Mouse Model
Volume: 92
04/09/2019 Authors: Tyor W; Haile W; Gavegnano C; Bimonte-Nelson H; Koneru R; Maroun L; Schinazi R -
Novel HBV capsid assembly modulator inhibits pregenomic RNA encapsidation by accelerating capsid assembly kinetics and disrupting core protein dephosphorylation
Volume: 70 Page(s): E457 - E457
04/01/2019 Authors: Bassit L; Verma K; Ono SK; Cox B; Amblard F; Schinazi RF -
Synthetic efforts towards the preparation of 2 '-dihalogenated nucleotide prodrugs
Volume: 257
03/31/2019 Authors: Mengshetti S; Zhou L; Sari O; De Shutter C; Zhou S; Chen Z; Zhang H; Khalil A; Li H; Ovadia R -
Efficient synthetic methods of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their phosphoramidate prodrugs
Volume: 257
03/31/2019 Authors: Cho JH; Choi SM; Kim JS; Amblard F; Bassit LC; Schinazi RF -
Synthesis of 2-fluoro-substituted and 2,6-modified purine 2',3'-dideoxy-2',3'-difluoro-d-arabinofuranosyl nucleosides from d-xylose.
Tetrahedron Volume: 75 Page(s): 2037 - 2046
03/29/2019 Authors: Sivets GG; Amblard F; Schinazi RF -
Discovery of a Series of 2'--Fluoro,2'--bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
J Med Chem Volume: 62 Page(s): 1859 - 1874
02/28/2019 Authors: Mengshetti S; Zhou L; Sari O; De Schutter C; Zhang H; Cho JH; Tao S; Bassit LC; Verma K; Domaoal RA -
Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.
Biochemistry Volume: 58 Page(s): 900 - 907
02/19/2019 Authors: Muzzarelli KM; Kuiper B; Spellmon N; Brunzelle J; Hackett J; Amblard F; Zhou S; Liu P; Kovari IA; Yang Z -
Synthesis and anti-HCV activity of -d-2'-deoxy-2'--chloro-2'--fluoro and -d-2'-deoxy-2'--bromo-2'--fluoro nucleosides and their phosphoramidate prodrugs.
Bioorg Med Chem Volume: 27 Page(s): 664 - 676
02/15/2019 Authors: Ovadia R; Khalil A; Li H; De Schutter C; Mengshetti S; Zhou S; Bassit L; Coats SJ; Amblard F; Schinazi RF -
Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".
J Virol Volume: 93
02/01/2019 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B -
Long-term virological and adherence outcomes to antiviral treatment in a 4-year cohort chronic HBV study.
Antivir Ther Volume: 24 Page(s): 567 - 579
01/01/2019 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Ferreira AS; Hori PC; Ganova-Raeva LM; Khudyakov Y; Schinazi RF; Carrilho FJ -
Disparate effects of cytotoxic chemotherapy on the antiviral activity of antiretroviral therapy: implications for treatments of HIV-infected cancer patients.
Antivir Ther Volume: 24 Page(s): 177 - 186
01/01/2019 Authors: Medina-Moreno S; Zapata JC; Cottrell ML; Le NM; Tao S; Bryant J; Sausville E; Schinazi RF; Kashuba AD; Redfield RR -
Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts.
J Biol Chem Volume: 293 Page(s): 16402 - 16412
10/19/2018 Authors: Mereby SA; Maehigashi T; Holler JM; Kim D-H; Schinazi RF; Kim B -
Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages.
Retrovirology Volume: 15 Page(s): 69
10/13/2018 Authors: Mahboubi B; Gavegnano C; Kim D-H; Schinazi RF; Kim B -
Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex.
Nucleic Acids Res Volume: 46 Page(s): 9711 - 9725
10/12/2018 Authors: Handa S; Jiang Y; Tao S; Foreman R; Schinazi RF; Miller JF; Ghosh P -
Mononuclear Phagocyte Inhibition in a HIV Associated Neurocognitive Disorders Mouse Model
Volume: 84 Page(s): S62 - S63
10/01/2018 Authors: Tyor W; Gavegnano C; Haile W; Bimonte-Nelson H; Koneru R; Maroun L; Schinazi R -
Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.
J Virol Volume: 92
09/15/2018 Authors: Mavigner M; Habib J; Deleage C; Rosen E; Mattingly C; Bricker K; Kashuba A; Amblard F; Schinazi RF; Lawson B -
Rational development of HBV capsid assembly modifiers aided by molecular dynamics
Volume: 256
08/19/2018 Authors: Pavlova A; Bassit L; Cox B; Korablyov M; Chipot C; Schinazi R; Gumbart J -
HIV transmission in discordant couples in Africa in the context of antiretroviral therapy availability.
AIDS Volume: 32 Page(s): 1613 - 1623
07/31/2018 Authors: Woodson E; Goldberg A; Michelo C; Basu D; Tao S; Schinazi R; Jiang Y; Kilembe W; Karita E; Allen S -
Correction: Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice.
Oncotarget Volume: 9 Page(s): 30472
07/13/2018 Authors: Reeves PM; Abbaslou MA; Kools FRW; Vutipongsatorn K; Tong X; Gavegnano C; Schinazi RF; Poznansky MC -
Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.
Bioorg Med Chem Lett Volume: 28 Page(s): 2165 - 2170
07/01/2018 Authors: Amblard F; Zhou S; Liu P; Yoon J; Cox B; Muzzarelli K; Kuiper BD; Kovari LC; Schinazi RF -
Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient.
Hepatology Volume: 67 Page(s): 2051 - 2054
05/01/2018 Authors: Ono SK; Bassit L; Van Vaisberg V; Avancini Ferreira Alves V; Caldini EG; Herman BD; Shabman R; Fedorova NB; Paranagu-Vezozzo D; Sampaio CT -
Mobile Health Intervention to Reduce HIV Transmission: A Randomized Trial of Behaviorally Enhanced HIV Treatment as Prevention (B-TasP).
J Acquir Immune Defic Syndr Volume: 78 Page(s): 34 - 42
05/01/2018 Authors: Kalichman SC; Cherry C; Kalichman MO; Eaton LA; Kohler JJ; Montero C; Schinazi RF -
The effects of JAK inhibitors in a mouse model of HIV neurocognitive disorders
Volume: 90
04/10/2018 Authors: Tyor W; Haile W; Gavegnano C; Bimonte-Nelson H; Koneru R; Schinazi R -
Baricitinib Reverses HIV Associated Neurocognitive Disorders in a SCID Murine Model
Volume: 13 Page(s): S29 - S29
04/01/2018 Authors: Gavegnano C; Haile W; Koneru R; Tao S; Hurwitz S; Schinazi R; Tyor W -
Baricitinib Reverses HIV Associated Neurocognitive Disorders in a SCID Murine Model
Volume: 24 Page(s): S29 - S29
04/01/2018 Authors: Gavegnano C; Haile W; Koneru R; Tao S; Hurwitz S; Schinazi R; Tyor W -
A research agenda for curing chronic hepatitis B virus infection.
Hepatology Volume: 67 Page(s): 1127 - 1131
03/01/2018 Authors: Alter H; Block T; Brown N; Brownstein A; Brosgart C; Chang K-M; Chen P-J; Chisari FV; Cohen C; El-Serag H -
Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop.
Antiviral Res Volume: 150 Page(s): 93 - 100
02/01/2018 Authors: Block TM; Alter H; Brown N; Brownstein A; Brosgart C; Chang K-M; Chen P-J; Cohen C; El-Serag H; Feld J -
Towards HBV curative therapies.
Liver Int Volume: 38 Suppl 1 Page(s): 102 - 114
02/01/2018 Authors: Schinazi RF; Ehteshami M; Bassit L; Asselah T -
Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure?
Liver Int Volume: 38 Suppl 1 Page(s): 7 - 13
02/01/2018 Authors: Asselah T; Marcellin P; Schinazi RF -
Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus.
Infect Disord Drug Targets Volume: 18 Page(s): 224 - 232
01/01/2018 Authors: Kuiper BD; Muzzarelli KM; Keusch BJ; Holcomb J; Amblard F; Liu P; Zhou S; Kovari IA; Yang Z; Schinazi RF -
Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination.
J Org Chem Volume: 82 Page(s): 13171 - 13178
12/15/2017 Authors: De Schutter C; Sari O; Coats SJ; Amblard F; Schinazi RF -
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
PLoS Pathog Volume: 13 Page(s): e1006740
12/01/2017 Authors: Gavegnano C; Brehm JH; Dupuy FP; Talla A; Ribeiro SP; Kulpa DA; Cameron C; Santos S; Hurwitz SJ; Marconi VC -
Synthesis and anti-HCV activity of a series of -d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.
Bioorg Med Chem Lett Volume: 27 Page(s): 5296 - 5299
12/01/2017 Authors: Chen Z; Cox BD; Garnier-Amblard EC; McBrayer TR; Coats SJ; Schinazi RF; Amblard F -
Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice.
Oncotarget Volume: 8 Page(s): 94040 - 94053
11/07/2017 Authors: Reeves PM; Abbaslou MA; Kools FRW; Vutipongsatorn K; Tong X; Gavegnano C; Schinazi RF; Poznansky MC -
Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease.
Biochem Biophys Res Commun Volume: 492 Page(s): 668 - 673
10/28/2017 Authors: Kuiper BD; Slater K; Spellmon N; Holcomb J; Medapureddy P; Muzzarelli KM; Yang Z; Ovadia R; Amblard F; Kovari IA -
Metabolism of Nucleosides and Nucleotides Prodrugs.
Curr Pharm Des
10/11/2017 Authors: De Schutter C; Ehteshami M; Hammond ET; Amblard F; Schinazi RF -
Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.
Eur J Med Chem Volume: 138 Page(s): 407 - 421
09/29/2017 Authors: Sari O; Boucle S; Cox BD; Ozturk T; Russell OO; Bassit L; Amblard F; Schinazi RF -
A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase is dispensable for HIV-1 infection in dividing and nondividing cells.
J Biol Chem Volume: 292 Page(s): 14016 - 14025
08/25/2017 Authors: Goetze RW; Kim D-H; Schinazi RF; Kim B -
Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network.
Antiviral Res Volume: 144 Page(s): 223 - 246
08/01/2017 Authors: Aliota MT; Bassit L; Bradrick SS; Cox B; Garcia-Blanco MA; Gavegnano C; Friedrich TC; Golos TG; Griffin DE; Haddow AD -
Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.
Antimicrob Agents Chemother Volume: 61
08/01/2017 Authors: Ehteshami M; Zhou L; Amiralaei S; Shelton JR; Cho JH; Zhang H; Li H; Lu X; Ozturk T; Stanton R -
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
J Med Chem Volume: 60 Page(s): 5424 - 5437
07/13/2017 Authors: Zhou S; Mahmoud S; Liu P; Zhou L; Ehteshami M; Bassit L; Tao S; Domaoal RA; Sari O; Schutter CD -
Pharmacokinetics and Placental Transfer of Elvitegravir, Dolutegravir, and Other Antiretrovirals during Pregnancy.
Antimicrob Agents Chemother Volume: 61
06/01/2017 Authors: Rimawi BH; Johnson E; Rajakumar A; Tao S; Jiang Y; Gillespie S; Schinazi RF; Mirochnick M; Badell ML; Chakraborty R -
Characterization of -d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
Antimicrob Agents Chemother Volume: 61
04/01/2017 Authors: Ehteshami M; Tao S; Zandi K; Hsiao H-M; Jiang Y; Hammond E; Amblard F; Russell OO; Merits A; Schinazi RF -
Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.
Tetrahedron Lett Volume: 58 Page(s): 642 - 644
02/15/2017 Authors: Sari O; Bassit L; Gavegnano C; McBrayer TR; McCormick L; Cox B; Coats SJ; Amblard F; Schinazi RF -
Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.
Bioorg Med Chem Lett Volume: 27 Page(s): 904 - 910
02/15/2017 Authors: Boucle S; Lu X; Bassit L; Ozturk T; Russell OO; Amblard F; Coats SJ; Schinazi RF -
Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates.
Nucleosides Nucleotides Nucleic Acids Volume: 36 Page(s): 66 - 82
01/02/2017 Authors: Mahmoud S; Li H; McBrayer TR; Bassit L; Hammad SF; Coats SJ; Amblard F; Schinazi RF -
Jak Inhibitors Modulate Production of Replication-Competent Zika Virus in Human Hofbauer, Trophoblasts, and Neuroblastoma cells.
Pathog Immun Volume: 2 Page(s): 199 - 218
01/01/2017 Authors: Gavegnano C; Bassit LC; Cox BD; Hsiao H-M; Johnson EL; Suthar M; Chakraborty R; Schinazi RF -
From HCV To HBV Cure.
Liver Int Volume: 37 Suppl 1 Page(s): 73 - 80
01/01/2017 Authors: Schinazi RF; Asselah T -
Substrates and Inhibitors of SAMHD1.
PLoS One Volume: 12 Page(s): e0169052
01/01/2017 Authors: Hollenbaugh JA; Shelton J; Tao S; Amiralaei S; Liu P; Lu X; Goetze RW; Zhou L; Nettles JH; Schinazi RF -
Anti-human immunodeficiency activity of novel 2-arylpyrrolidine analogs.
Med Chem Res Volume: 26 Page(s): 101 - 108
01/01/2017 Authors: Martirosyan AH; Gasparyan SP; Alexanyan MV; Harutyunyan GK; Panosyan HA; Schinazi RF -
Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs.
Chem Rev Volume: 116 Page(s): 14379 - 14455
12/14/2016 Authors: Shelton J; Lu X; Hollenbaugh JA; Cho JH; Amblard F; Schinazi RF -
Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities.
Clin Liver Dis Volume: 20 Page(s): 737 - 749
11/01/2016 Authors: Boucle S; Bassit L; Ehteshami M; Schinazi RF -
Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study.
Lancet Gastroenterol Hepatol Volume: 1 Page(s): 97 - 104
10/01/2016 Authors: Lau G; Benhamou Y; Chen G; Li J; Shao Q; Ji D; Li F; Li B; Liu J; Hou J -
Semi-quantitative Detection of HIV-1 RNA in Plasma Using an In-house RT-PCR Technique for Monitoring Self-reported Antiretroviral Treatment Adherence
Volume: 32 Page(s): 409 - 409
10/01/2016 Authors: Michelo C; Sharkey T; Mfune T; Basu D; Tao S; Jiang Y; Schinazi R; Kilembe W; Allen S; Hunter E -
Acute HIV-1 Transmission in Zambian Couples in the Post-HAART Era: Treatment Failure or Lack of Adherence?
Volume: 32 Page(s): 257 - 257
10/01/2016 Authors: Woodson E; Basu D; Goldberg A; Kilembe W; Inambao M; Tao S; Schinazi R; Hunter E; Allen S -
Randomized Factorial Trial of Phone-Delivered Support Counseling and Daily Text Message Reminders for HIV Treatment Adherence.
J Acquir Immune Defic Syndr Volume: 73 Page(s): 47 - 54
09/01/2016 Authors: Kalichman SC; Kalichman MO; Cherry C; Eaton LA; Cruess D; Schinazi RF -
Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorg Med Chem Lett Volume: 26 Page(s): 4101 - 4105
08/15/2016 Authors: Stanton RA; Lu X; Detorio M; Montero C; Hammond ET; Ehteshami M; Domaoal RA; Nettles JH; Feraud M; Schinazi RF -
The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model.
Neurobiol Dis Volume: 92 Page(s): 137 - 143
08/01/2016 Authors: Haile WB; Gavegnano C; Tao S; Jiang Y; Schinazi RF; Tyor WR -
Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
Antimicrob Agents Chemother Volume: 60 Page(s): 4659 - 4669
08/01/2016 Authors: Ehteshami M; Tao S; Ozturk T; Zhou L; Cho JH; Zhang H; Amiralaei S; Shelton JR; Lu X; Khalil A -
SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.
Virology Volume: 495 Page(s): 92 - 100
08/01/2016 Authors: Bonifati S; Daly MB; St Gelais C; Kim SH; Hollenbaugh JA; Shepard C; Kennedy EM; Kim D-H; Schinazi RF; Kim B -
Zika Virus Infects Human Placental Macrophages.
Cell Host Microbe Volume: 20 Page(s): 83 - 90
07/13/2016 Authors: Quicke KM; Bowen JR; Johnson EL; McDonald CE; Ma H; O'Neal JT; Rajakumar A; Wrammert J; Rimawi BH; Pulendran B -
HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.
HIV Med Volume: 17 Page(s): 411 - 424
06/01/2016 Authors: Lambert CT; Sandesara PB; Hirsh B; Shaw LJ; Lewis W; Quyyumi AA; Schinazi RF; Post WS; Sperling L -
Editorial overview: Antiviral strategies.
Curr Opin Virol Volume: 18 Page(s): v - vi
06/01/2016 Authors: De Clercq E; Schinazi RF -
Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.
Virology Volume: 493 Page(s): 162 - 172
06/01/2016 Authors: Clark KB; Hsiao H-M; Bassit L; Crowe JE; Schinazi RF; Perng GC; Villinger F -
A new oxygen modification cyclooctaoxygen binds to nucleic acids as sodium crown complex.
Biochim Biophys Acta Volume: 1860 Page(s): 785 - 794
04/01/2016 Authors: Kesel AJ; Day CW; Montero CM; Schinazi RF -
A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin.
Antimicrob Agents Chemother Volume: 60 Page(s): 2018 - 2027
04/01/2016 Authors: Kulkarni AS; Damha MJ; Schinazi RF; Mo H; Doehle B; Sagan SM; Gtte M -
Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.
Virology Volume: 491 Page(s): 106 - 114
04/01/2016 Authors: Hollenbaugh JA; Montero C; Schinazi RF; Munger J; Kim B -
Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.
ACS Med Chem Lett Volume: 7 Page(s): 17 - 22
01/14/2016 Authors: Zhou L; Zhang H; Tao S; Ehteshami M; Cho JH; McBrayer TR; Tharnish P; Whitaker T; Amblard F; Coats SJ -
HIV latency reversal research and the potential effects on the central nervous system: is concern warranted?
J Int AIDS Soc Volume: 19 Page(s): 21008
01/01/2016 Authors: Anderson AM; Schinazi RF; Tyor WR -
NOVEL CAPSID ASSEMBLY EFFECTORS INHIBIT HBV CCCDNA FORMATION IN AN HBEAG REPORTER CELL-BASED ASSAY
Volume: 64 Page(s): S162 - S162
01/01/2016 Authors: Bassit L; Boucle S; Amblard F; Zhou L; Zhang HW; Hsiao H-M; Ozturk T; Russell O; Schinazi RF -
Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses.
J Biol Chem Volume: 290 Page(s): 30078 - 30086
12/11/2015 Authors: Lenzi GM; Domaoal RA; Kim D-H; Schinazi RF; Kim B -
Complete cure after three weeks of all-oral triple-direct acting antiviral (DAA) regimens in non-cirrhotic chronic hepatitis C genotype 1b Chinese subjects (SODAPI STUDY)
HEPATOLOGY Volume: 62 Page(s): 1394A - 1394A
12/01/2015 Authors: Lau GK; Benhamou Y; Chen G; Li J; Shao Q; Ji D; Li F; Li B; Liu J; Hou J -
Synthesis of dihydropyrimidine ,-diketobutanoic acid derivatives targeting HIV integrase.
Eur J Med Chem Volume: 104 Page(s): 127 - 138
11/02/2015 Authors: Sari O; Roy V; Mtifiot M; Marchand C; Pommier Y; Bourg S; Bonnet P; Schinazi RF; Agrofoglio LA -
Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cells.
Virology Volume: 485 Page(s): 313 - 321
11/01/2015 Authors: Hollenbaugh JA; Schader SM; Schinazi RF; Kim B -
Ligand similarity guided receptor selection enhances docking accuracy and recall for non-nucleoside HIV reverse transcriptase inhibitors.
J Mol Model Volume: 21 Page(s): 282
11/01/2015 Authors: Stanton RA; Nettles JH; Schinazi RF -
Four years real-life experience with antiviral adherence in chronic hepatitis B infection in a tertiary university hospital
Volume: 62 Page(s): 963A - 963A
10/01/2015 Authors: Abreu RM; Bassit LC; Tao S; Jiang Y; Paranagua-Vezozzo D; Schinazi RF; Carrilho FJ; Ono SK -
Anti-HIV activity of new pyrazolobenzothiazine 5,5-dioxide-based acetohydrazides.
Med Chem Res Volume: 24 Page(s): 3671 - 3680
10/01/2015 Authors: Khalid Z; Aslam S; Ahmad M; Munawar MA; Montero C; Detorio M; Parvez M; Schinazi RF -
Role of Marine Natural Products in the Genesis of Antiviral Agents.
Chem Rev Volume: 115 Page(s): 9655 - 9706
09/23/2015 Authors: Gogineni V; Schinazi RF; Hamann MT -
Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
Bioorg Med Chem Lett Volume: 25 Page(s): 3711 - 3715
09/01/2015 Authors: Boucle S; Tao S; Amblard F; Stanton RA; Nettles JH; Li C; McBrayer TR; Whitaker T; Coats SJ; Schinazi RF -
Predicting Zika virus structural biology: Challenges and opportunities for intervention.
Antivir Chem Chemother Volume: 24 Page(s): 118 - 126
08/01/2015 Authors: Cox BD; Stanton RA; Schinazi RF -
Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.
Gut Volume: 64 Page(s): 1314 - 1326
08/01/2015 Authors: Zeisel MB; Lucifora J; Mason WS; Sureau C; Beck J; Levrero M; Kann M; Knolle PA; Benkirane M; Durantel D -
Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase .
Proc Natl Acad Sci U S A Volume: 112 Page(s): 8596 - 8601
07/14/2015 Authors: Sohl CD; Szymanski MR; Mislak AC; Shumate CK; Amiralaei S; Schinazi RF; Anderson KS; Yin YW -
Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.
Tetrahedron Lett Volume: 56 Page(s): 3587 - 3590
06/03/2015 Authors: Cho JH; Coats SJ; Schinazi RF -
Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial.
Clin Infect Dis Volume: 60 Page(s): 1708 - 1714
06/01/2015 Authors: Vanpouille C; Lisco A; Grivel J-C; Bassit LC; Kauffman RC; Sanchez J; Schinazi RF; Lederman MM; Rodriguez B; Margolis L -
Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients.
AIDS Volume: 29 Page(s): 1113 - 1115
06/01/2015 Authors: Lahiri CD; Tao S; Jiang Y; Sheth AN; Acosta EP; Marconi VC; Armstrong WS; Schinazi RF; Vunnava A; Sanford S -
Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis.
Oncotarget Volume: 6 Page(s): 11047 - 11060
05/10/2015 Authors: Stoyanov E; Ludwig G; Mizrahi L; Olam D; Schnitzer-Perlman T; Tasika E; Sass G; Tiegs G; Jiang Y; Nie T -
-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
J Med Chem Volume: 58 Page(s): 3445 - 3458
04/23/2015 Authors: Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Pradere U; Cho JH -
Structural informatics modeling of Daclatasvir and analogs reveals asymmetric binding to HCV-NS5A: Dual mechanisms responsible for picomolar activity and acquired resistance
Volume: 249
03/22/2015 Authors: Nettles J; Stanton R; Broyde J; Amblard F; Zhang H; Zhou L; Shi J; McBrayer T; Whitaker T; Coats S -
Molecular docking and antiviral activity of N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides.
Bioorg Med Chem Lett Volume: 25 Page(s): 1348 - 1351
03/15/2015 Authors: Ahmad M; Aslam S; Rizvi SUF; Muddassar M; Ashfaq UA; Montero C; Ollinger O; Detorio M; Gardiner JM; Schinazi RF -
Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template.
Antiviral Res Volume: 115 Page(s): 75 - 82
03/01/2015 Authors: Nguyen LA; Domaoal RA; Kennedy EM; Kim D-H; Schinazi RF; Kim B -
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease.
Virology Volume: 476 Page(s): 196 - 205
02/01/2015 Authors: Kennedy EM; Bassit LC; Mueller H; Kornepati AVR; Bogerd HP; Nie T; Chatterjee P; Javanbakht H; Schinazi RF; Cullen BR -
Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.
Future Microbiol Volume: 10 Page(s): 1773 - 1782
01/01/2015 Authors: Sluis-Cremer N; Wainberg MA; Schinazi RF -
Synthesis and antiviral evaluation of 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl 2,6-disubstituted purine nucleosides.
Heterocycl Comm Volume: 21 Page(s): 315 - 327
01/01/2015 Authors: Schinazi RF; Sivets GG; Detorio MA; McBrayer TR; Whitaker T; Coats SJ; Amblard F -
Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses.
Retrovirology Volume: 11 Page(s): 111
12/19/2014 Authors: Lenzi GM; Domaoal RA; Kim D-H; Schinazi RF; Kim B -
Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.
J Med Chem Volume: 57 Page(s): 10031 - 10043
12/11/2014 Authors: Nettles JH; Stanton RA; Broyde J; Amblard F; Zhang H; Zhou L; Shi J; McBrayer TR; Whitaker T; Coats SJ -
Nonlinear dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
PURINERGIC SIGNALLING Volume: 10 Page(s): 696 - 696
12/01/2014 Authors: Hollenbaugh JA; Tao S; Lenzi G; Ryu S; Kim D-H; Schinazi RF; Kim B -
Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
Bioorg Med Chem Volume: 22 Page(s): 6665 - 6671
12/01/2014 Authors: Cho JH; Bondana L; Detorio MA; Montero C; Bassit LC; Amblard F; Coats SJ; Schinazi RF -
Erratum to: Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.
Arch Pharm Res Volume: 37 Page(s): 1504
11/01/2014 Authors: Aslam S; Ahmad M; Zia-Ur-Rehman M; Montero C; Detorio M; Parvez M; Schinazi RF -
Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.
Arch Pharm Res Volume: 37 Page(s): 1380 - 1393
11/01/2014 Authors: Aslam S; Ahmad M; Zia-Ur-Rehman M; Montero C; Detorio M; Parvez M; Schinazi RF -
GENETIC DIVERSITY OF RT-SHIV RESIDUAL VIREMIA AND VIRAL RESERVOIRS IN RHESUS MACAQUES AFTER TREATMENT WITH FIVE ANTIRETROVIRAL AGENTS
JOURNAL OF MEDICAL PRIMATOLOGY Volume: 43 Page(s): 403 - 403
10/01/2014 Authors: Kauffman RC; Villalobos A; Bowen JH; Schinazi RF; North TW -
JAK INHIBITORS TOFACITINIB AND RUXOLITINIB EMPLOY A NOVEL MECHANISM TO INHIBIT HIV-1 REPLICATION AND PRO-HIV EVENTS IN PRIMARY RHESUS MACAQUE AND HUMAN LYMPHOCYTES AND MACROPHAGES
JOURNAL OF MEDICAL PRIMATOLOGY Volume: 43 Page(s): 381 - 381
10/01/2014 Authors: Gavegnano C; Montero C; Dupuy F; Brehm J; Sekaly R; Schinazi RF -
Synthesis of nucleoside phosphate and phosphonate prodrugs.
Chem Rev Volume: 114 Page(s): 9154 - 9218
09/24/2014 Authors: Pradere U; Garnier-Amblard EC; Coats SJ; Amblard F; Schinazi RF -
dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.
Retrovirology Volume: 11 Page(s): 63
08/27/2014 Authors: Hollenbaugh JA; Tao S; Lenzi GM; Ryu S; Kim D-H; Diaz-Griffero F; Schinazi RF; Kim B -
Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women.
Antimicrob Agents Chemother Volume: 58 Page(s): 4014 - 4019
07/01/2014 Authors: Geisler WM; Pascual MLG; Mathew J; Koltun WD; Morgan F; Batteiger BE; Mayes A; Tao S; Hurwitz SJ; Sayada C -
Cost analysis of sofosbuvir/ribavirin versus sofosbuvir/simeprevir for genotype 1 hepatitis C virus in interferon-ineligible/intolerant individuals.
Hepatology Volume: 60 Page(s): 37 - 45
07/01/2014 Authors: Hagan LM; Sulkowski MS; Schinazi RF -
Enhanced antiretroviral therapy in rhesus macaques improves RT-SHIV viral decay kinetics.
Antimicrob Agents Chemother Volume: 58 Page(s): 3927 - 3933
07/01/2014 Authors: North TW; Villalobos A; Hurwitz SJ; Deere JD; Higgins J; Chatterjee P; Tao S; Kauffman RC; Luciw PA; Kohler JJ -
Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.
J Biol Chem Volume: 289 Page(s): 16640
06/13/2014 Authors: Amie SM; Daly MB; Noble E; Schinazi RF; Bambara RA; Kim B -
Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.
Antivir Chem Chemother Volume: 23 Page(s): 197 - 215
04/11/2014 Authors: Kesel AJ; Huang Z; Murray MG; Prichard MN; Caboni L; Nevin DK; Fayne D; Lloyd DG; Detorio MA; Schinazi RF -
Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors against feline immunodeficiency virus in feline peripheral blood mononuclear cells.
Am J Vet Res Volume: 75 Page(s): 273 - 281
03/01/2014 Authors: Schwartz AM; McCrackin MA; Schinazi RF; Hill PB; Vahlenkamp TW; Tompkins MB; Hartmann K -
HCV direct-acting antiviral agents: the best interferon-free combinations.
Liver Int Volume: 34 Suppl 1 Page(s): 69 - 78
02/01/2014 Authors: Schinazi R; Halfon P; Marcellin P; Asselah T -
Chutes and ladders in hepatitis C nucleoside drug development.
Antiviral Res Volume: 102 Page(s): 119 - 147
02/01/2014 Authors: Coats SJ; Garnier-Amblard EC; Amblard F; Ehteshami M; Amiralaei S; Zhang H; Zhou L; Boucle SRL; Lu X; Bondada L -
Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine.
Antiviral Res Volume: 101 Page(s): 62 - 67
01/01/2014 Authors: Meteer JD; Schinazi RF; Mellors JW; Sluis-Cremer N -
Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.
Antimicrob Agents Chemother Volume: 58 Page(s): 1977 - 1986
01/01/2014 Authors: Gavegnano C; Detorio M; Montero C; Bosque A; Planelles V; Schinazi RF -
Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.
PLoS One Volume: 9 Page(s): e86997
01/01/2014 Authors: Wadford DA; Kauffman RC; Deere JD; Aoki ST; Stanton RA; Higgins J; Van Rompay KKA; Villalobos A; Nettles JH; Schinazi RF -
Comparison of Three 2 '-C-Methyl Guanosine Prodrugs for Hepatitis C including a Novel beta-D-2 '-C-Me-2,6-Diaminopurine Ribonucleoside Phosphoramidate (RS-1389): Interspecies Hepatocyte and Human Cardiomyocyte Metabolism Profiles
Volume: 60 Page(s): 1170A - 1171A
01/01/2014 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Coats SJ; Schinazi RF -
HCV Nucleoside Inhibitors can Exhibit Genotype Specific Differences in Activity
Volume: 60 Page(s): 1169A - 1170A
01/01/2014 Authors: Anton ED; Strommen K; Huang W; Rivera AA; Petropoulos CJ; Amblard F; Schinazi RF; Reeves JD -
A 4-N-Hydroxycytidine Ribonucleoside Phosphoramidate Delivers Intracellularly Three Distinct Active 5 '-Triphosphate Nucleosides that are Potent Inhibitors of HCV Polymerase
Volume: 60 Page(s): 1162A - 1162A
01/01/2014 Authors: Schinazi RF; Amblard F; Tao S; Ehteshami M; Amiralaei S; Li H; Shelton J; Whitaker T; McBrayer TR; Coats SJ -
Residual viremia in an RT-SHIV rhesus macaque HAART model marked by the presence of a predominant plasma clone and a lack of viral evolution.
PLoS One Volume: 9 Page(s): e88258
01/01/2014 Authors: Kauffman RC; Villalobos A; Bowen JH; Adamson L; Schinazi RF -
Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART.
PLoS One Volume: 9 Page(s): e87914
01/01/2014 Authors: Deere JD; Kauffman RC; Cannavo E; Higgins J; Villalobos A; Adamson L; Schinazi RF; Luciw PA; North TW -
Approaches to hepatitis C treatment and cure using NS5A inhibitors.
Infect Drug Resist Volume: 7 Page(s): 41 - 56
01/01/2014 Authors: Kohler JJ; Nettles JH; Amblard F; Hurwitz SJ; Bassit L; Stanton RA; Ehteshami M; Schinazi RF -
All-oral, interferon-free treatment for chronic hepatitis C: cost-effectiveness analyses.
J Viral Hepat Volume: 20 Page(s): 847 - 857
12/01/2013 Authors: Hagan LM; Yang Z; Ehteshami M; Schinazi RF -
Treatment as prevention and cure towards global eradication of hepatitis C virus.
Trends Microbiol Volume: 21 Page(s): 625 - 633
12/01/2013 Authors: Hagan LM; Wolpe PR; Schinazi RF -
Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem Lett Volume: 23 Page(s): 6325 - 6330
12/01/2013 Authors: Bondada L; Rondla R; Pradere U; Liu P; Li C; Bobeck D; McBrayer T; Tharnish P; Courcambeck J; Halfon P -
Synthesis, docking, and biological studies of phenanthrene -diketo acids as novel HIV-1 integrase inhibitors.
Bioorg Med Chem Lett Volume: 23 Page(s): 6146 - 6151
11/15/2013 Authors: Sharma H; Sanchez TW; Neamati N; Detorio M; Schinazi RF; Cheng X; Buolamwini JK -
Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly.
Antimicrob Agents Chemother Volume: 57 Page(s): 5344 - 5354
11/01/2013 Authors: Wu G; Liu B; Zhang Y; Li J; Arzumanyan A; Clayton MM; Schinazi RF; Wang Z; Goldmann S; Ren Q -
Prodrug strategies for improved efficacy of nucleoside antiviral inhibitors.
Curr Opin HIV AIDS Volume: 8 Page(s): 556 - 564
11/01/2013 Authors: Hurwitz SJ; Schinazi RF -
Significance of endangered and threatened plant natural products in the control of human disease.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 16832 - 16837
10/15/2013 Authors: Ibrahim MA; Na M; Oh J; Schinazi RF; McBrayer TR; Whitaker T; Doerksen RJ; Newman DJ; Zachos LG; Hamann MT -
Phosphoramidate Prodrugs of beta-D-2 '-C-Me-2,6-diaminopurine Ribonucleoside are Potent Inhibitors of Hepatitis C Virus (HCV) Replication Delivering Two Active Nucleoside Triphosphates
Volume: 58 Page(s): 437A - 437A
10/01/2013 Authors: Schinazi RF; Zhou L; Zhang H; Ehteshami M; Tao S; Bassit LC; Suesserman J; Whitaker T; McBrayer TR; Cho J-H -
Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides.
Eur J Med Chem Volume: 67 Page(s): 398 - 408
09/01/2013 Authors: Hamada M; Roy V; McBrayer TR; Whitaker T; Urbina-Blanco C; Nolan SP; Balzarini J; Snoeck R; Andrei G; Schinazi RF -
Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.
ACS Med Chem Lett Volume: 4 Page(s): 747 - 751
08/08/2013 Authors: Bondada L; Detorio M; Bassit L; Tao S; Montero CM; Singletary TM; Zhang H; Zhou L; Cho J-H; Coats SJ -
Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.
J Biol Chem Volume: 288 Page(s): 20683 - 20691
07/12/2013 Authors: Amie SM; Daly MB; Noble E; Schinazi RF; Bambara RA; Kim B -
Epigenetic effects of viral proteins on global levels of 5-hydroxymethylcytosine in HBV- and HCV-associated hepatocellular carcinoma in mice
CANCER RESEARCH Volume: 73
07/01/2013 Authors: Jiang Y; Nie T; Kohler J; Bassit L; Goldenberg D; Feitelson M; Schinazi RF -
Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett Volume: 23 Page(s): 3385 - 3388
06/01/2013 Authors: Zhou L; Amblard F; Zhang H; McBrayer TR; Detorio MA; Whitaker T; Coats SJ; Schinazi RF -
Randomized clinical trial of HIV treatment adherence counseling interventions for people living with HIV and limited health literacy.
J Acquir Immune Defic Syndr Volume: 63 Page(s): 42 - 50
05/01/2013 Authors: Kalichman SC; Cherry C; Kalichman MO; Amaral C; White D; Grebler T; Eaton LA; Cruess D; Detorio MA; Caliendo AM -
Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Bioorg Med Chem Lett Volume: 23 Page(s): 2031 - 2034
04/01/2013 Authors: Amblard F; Zhang H; Zhou L; Shi J; Bobeck DR; Nettles JH; Chavre S; McBrayer TR; Tharnish P; Whitaker T -
NOVEL EFFECTOR OF HBV CAPSID ASSEMBLY REDUCES THE ACTIVITY OF cccDNA AND INTERACTS SYNERGISTICALLY WITH NUCLEOSIDE ANALOGS IN THE HUMAN HEPATOCYTES
Volume: 58 Page(s): S298 - S299
04/01/2013 Authors: Bassit L; Ozturk T; Tao S; Boucle SR; Ehteshami M; Zlotnick A; Feitelson MA; Schinazi RF -
BL-8030: A NOVEL, POTENT, SELECTIVE, ORALLY AVAILABLE INHIBITOR OF HEPATITIS C VIRUS NS3/4A PROTEASE
Volume: 58 Page(s): S475 - S475
04/01/2013 Authors: Halfon P; Courcambeck J; Whitaker T; Tharnish PM; McBrayer TR; Coats SJ; Pereg Y; Tabakman R; Schumann J; Matto M -
Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages.
Antimicrob Agents Chemother Volume: 57 Page(s): 1262 - 1269
03/01/2013 Authors: Gavegnano C; Detorio MA; Bassit L; Hurwitz SJ; North TW; Schinazi RF -
Best strategies for global HCV eradication.
Liver Int Volume: 33 Suppl 1 Page(s): 68 - 79
02/01/2013 Authors: Hagan LM; Schinazi RF -
Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.
J Org Chem Volume: 78 Page(s): 723 - 727
01/18/2013 Authors: Cho JH; Amblard F; Coats SJ; Schinazi RF -
Biochemical characterization of beta-D-2 '-C-methyl-2,6-diaminopurine-ribonucleoside-5 '-triphosphate as a potent inhibitor of hepatitis C virus (HCV) polymerase
Volume: 18 Page(s): A10 - A10
01/01/2013 Authors: Ehteshami M; Amiralaei S; Shelton JR; Tao S; Suesserman JE; Zhang H-W; Zhou L; Coats SJ; Schinazi RF -
beta-D-2 '-C-Me-2,6-diaminopurine ribonucleoside phosphoramidates are potent and selective inhibitors of hepatitis C virus (HCV) and are bioconverted intracellularly to bioactive 2,6-diaminopurine- and guanosine-5 '-triphosphate forms
Volume: 18 Page(s): A57 - A57
01/01/2013 Authors: Schinazi RF; Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Detorio M -
Antiviral agents derived from novel 1-adamantyl singlet nitrenes.
Antivir Chem Chemother Volume: 23 Page(s): 113 - 128
12/07/2012 Authors: Kesel AJ; Weiss H-C; Schnleber A; Day CW; Barnard DL; Detorio MA; Schinazi RF -
Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosides.
Bioorg Med Chem Volume: 20 Page(s): 6885 - 6893
12/01/2012 Authors: Martnez-Montero S; Fernndez S; Sanghvi YS; Theodorakis EA; Detorio MA; McBrayer TR; Whitaker T; Schinazi RF; Gotor V; Ferrero M -
Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication.
Antimicrob Agents Chemother Volume: 56 Page(s): 6186 - 6191
12/01/2012 Authors: Schinazi RF; Bassit L; Clayton MM; Sun B; Kohler JJ; Obikhod A; Arzumanyan A; Feitelson MA -
Synthesis of 5'-methylene-phosphonate furanonucleoside prodrugs: application to D-2'-deoxy-2'--fluoro-2'--C-methyl nucleosides.
Org Lett Volume: 14 Page(s): 4426 - 4429
09/07/2012 Authors: Pradere U; Amblard F; Coats SJ; Schinazi RF -
Scaleable processes for the synthesis of (-)--D-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)--D-2-aminopurine dioxolane (APD).
Tetrahedron Volume: 68 Page(s): 5738 - 5743
07/22/2012 Authors: Zhou L; Coats SJ; Zhang H; Junxing S; Bobeck DR; Schinazi RF -
Synthesis and evaluation of novel potent HCV NS5A inhibitors.
Bioorg Med Chem Lett Volume: 22 Page(s): 4864 - 4868
07/15/2012 Authors: Zhang H; Zhou L; Amblard F; Shi J; Bobeck DR; Tao S; McBrayer TR; Tharnish PM; Whitaker T; Coats SJ -
Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.
Mol Pharmacol Volume: 82 Page(s): 125 - 133
07/01/2012 Authors: Sohl CD; Kasiviswanathan R; Kim J; Pradere U; Schinazi RF; Copeland WC; Mitsuya H; Baba M; Anderson KS -
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett Volume: 22 Page(s): 4064 - 4067
06/15/2012 Authors: Kim J; Wang L; Li Y; Becnel KD; Frey KM; Garforth SJ; Prasad VR; Schinazi RF; Liotta DC; Anderson KS -
Efficient synthesis of exo-N-carbamoyl nucleosides: application to the synthesis of phosphoramidate prodrugs.
Org Lett Volume: 14 Page(s): 2488 - 2491
05/18/2012 Authors: Cho JH; Coats SJ; Schinazi RF -
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.
Bioorg Med Chem Lett Volume: 22 Page(s): 3488 - 3491
05/15/2012 Authors: Shi J; Zhou L; Amblard F; Bobeck DR; Zhang H; Liu P; Bondada L; McBrayer TR; Tharnish PM; Whitaker T -
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin.
Antimicrob Agents Chemother Volume: 56 Page(s): 2604 - 2611
05/01/2012 Authors: Vanpouille C; Lisco A; Introini A; Grivel J-C; Munawwar A; Merbah M; Schinazi RF; Derudas M; McGuigan C; Balzarini J -
Use of dietary supplements among people living with HIV/AIDS is associated with vulnerability to medical misinformation on the internet.
AIDS Res Ther Volume: 9 Page(s): 1
01/10/2012 Authors: Kalichman SC; Cherry C; White D; Jones M; Kalichman MO; Detorio MA; Caliendo AM; Schinazi RF -
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs.
Nucleic Acids Res Volume: 40 Page(s): 381 - 390
01/01/2012 Authors: Herman BD; Schinazi RF; Zhang H-W; Nettles JH; Stanton R; Detorio M; Obikhod A; Pradre U; Coats SJ; Mellors JW -
Antiviral activity of nucleoside analogues against norovirus.
Antivir Ther Volume: 17 Page(s): 981 - 991
01/01/2012 Authors: Costantini VP; Whitaker T; Barclay L; Lee D; McBrayer TR; Schinazi RF; Vinj J -
Persistence and mobility of 2,4-D in unsaturated soil zone under winter wheat crop in sub-tropical region of India
AGRICULTURE ECOSYSTEMS & ENVIRONMENT Volume: 146 Page(s): 60 - 72
01/01/2012 Authors: Gupta M; Garg NK; Joshi H; Sharma MP -
Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors.
Drug Discov Today Technol Volume: 9 Page(s): e183 - e193
01/01/2012 Authors: Hurwitz SJ; Schinazi RF -
The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents.
Mol Biol Int Volume: 2012 Page(s): 625983
01/01/2012 Authors: Gavegnano C; Kennedy EM; Kim B; Schinazi RF -
Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.
Antivir Ther Volume: 17 Page(s): 1233 - 1242
01/01/2012 Authors: Shikuma CM; Nakamoto B; Shiramizu B; Liang C-Y; DeGruttola V; Bennett K; Paul R; Kallianpur K; Chow D; Gavegnano C -
Synthesis and Biological Evaluation of 4'-C,3'-O-Propylene-Linked Bicyclic Nucleosides.
European J Org Chem Volume: 2011 Page(s): 7390 - 7399
12/01/2011 Authors: Hatton W; Hunault J; Egorov M; Len C; Pipelier M; Blot V; Silvestre V; Fargeas V; An A; McBrayer T -
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
Bioorg Med Chem Lett Volume: 21 Page(s): 7094 - 7098
12/01/2011 Authors: Shi J; Zhou L; Zhang H; McBrayer TR; Detorio MA; Johns M; Bassit L; Powdrill MH; Whitaker T; Coats SJ -
Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
Bioorg Med Chem Lett Volume: 21 Page(s): 6788 - 6792
11/15/2011 Authors: Zhang H-W; Zhou L; Coats SJ; McBrayer TR; Tharnish PM; Bondada L; Detorio M; Amichai SA; Johns MD; Whitaker T -
In silico study supports the efficacy of a reduced dose regimen for stavudine.
Antiviral Res Volume: 92 Page(s): 372 - 377
11/01/2011 Authors: Hurwitz SJ; Schinazi RF -
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
Eur J Med Chem Volume: 46 Page(s): 3832 - 3844
09/01/2011 Authors: Zhang H-W; Detorio M; Herman BD; Solomon S; Bassit L; Nettles JH; Obikhod A; Tao S-J; Mellors JW; Sluis-Cremer N -
Food insufficiency and medication adherence among people living with HIV/AIDS in urban and peri-urban settings.
Prev Sci Volume: 12 Page(s): 324 - 332
09/01/2011 Authors: Kalichman SC; Pellowski J; Kalichman MO; Cherry C; Detorio M; Caliendo AM; Schinazi RF -
Sexual HIV transmission and antiretroviral therapy: a prospective cohort study of behavioral risk factors among men and women living with HIV/AIDS.
Ann Behav Med Volume: 42 Page(s): 111 - 119
08/01/2011 Authors: Kalichman SC; Cherry C; White D; Jones M; Grebler T; Kalichman MO; Detorio M; Caliendo AM; Schinazi RF -
The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase.
Antimicrob Agents Chemother Volume: 55 Page(s): 3758 - 3764
08/01/2011 Authors: Meteer JD; Koontz D; Asif G; Zhang H-W; Detorio M; Solomon S; Coats SJ; Sluis-Cremer N; Schinazi RF; Mellors JW -
Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection.
Tetrahedron Volume: 67 Page(s): 5487 - 5493
07/29/2011 Authors: Cho JH; Amblard F; Coats SJ; Schinazi RF -
Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase.
J Biol Chem Volume: 286 Page(s): 25047 - 25055
07/15/2011 Authors: Kennedy EM; Daddacha W; Slater R; Gavegnano C; Fromentin E; Schinazi RF; Kim B -
William H Prusoff dies at 90 - a renaissance man that revolutionized the treatment of herpesviruses and HIV.
Antivir Chem Chemother Volume: 21 Page(s): 219 - 220
07/04/2011 Authors: Schinazi RF -
Selection and characterization of HIV-1 with a novel S68 deletion in reverse transcriptase.
Antimicrob Agents Chemother Volume: 55 Page(s): 2054 - 2060
05/01/2011 Authors: Schinazi RF; Massud I; Rapp KL; Cristiano M; Detorio MA; Stanton RA; Bennett MA; Kierlin-Duncan M; Lennerstrand J; Nettles JH -
Synthesis and anti-HIV evaluation of 3'-triazolo nucleosides.
Nucleosides Nucleotides Nucleic Acids Volume: 30 Page(s): 264 - 270
04/01/2011 Authors: Roy V; Obikhod A; Zhang H-W; Coats SJ; Herman BD; Sluis-Cremer N; Agrofoglio LA; Schinazi RF -
Synthesis, biological evaluation, molecular modeling and 3D-QSAR studies of 3-keto salicylic acid chalcones as novel HIV-1 integrase inhibitors
Volume: 241
03/27/2011 Authors: Sharma H; Patil S; Neamati N; Schinazi RF; Buolamwini JK -
Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.
Bioorg Med Chem Volume: 19 Page(s): 2030 - 2045
03/15/2011 Authors: Sharma H; Patil S; Sanchez TW; Neamati N; Schinazi RF; Buolamwini JK -
GNS-227: A NEW POTENT AND SELECTIVE HCV NS3 PROTEASE INHIBITOR WITH A HIGH GENETIC BARRIER TO RESISTANCE
Volume: 54 Page(s): S478 - S478
03/01/2011 Authors: Halfon P; Courcambeck J; Whitaker T; Bouzidi M; Mcbrayer TR; Roche G; Tharnish PM; Pepe G; Schinazi RF; Coats SJ -
Universal profiling of HIV-1 pol for genotypic study and resistance analysis across subtypes.
Antivir Ther Volume: 16 Page(s): 1267 - 1275
01/01/2011 Authors: Nie T; Detorio M; Schinazi RF -
Frequent incorporation of non-canonical dUTP by human immunodeficiency virus type 1 reverse transcriptase in primary human macrophage
Volume: 16 Page(s): A125 - A125
01/01/2011 Authors: Kennedy EM; Daddacha W; Slater R; Gavegnano C; Fromentin E; Schinazi RE; Kim B -
Simian immunodeficiency virus macaque models of HIV latency.
Curr Opin HIV AIDS Volume: 6 Page(s): 57 - 61
01/01/2011 Authors: Deere JD; Schinazi RF; North TW -
Differential impact of mutations M184V, M184I and M184T in HIV-1 RT on entecavir incorporation and susceptibility
Volume: 16 Page(s): A65 - A65
01/01/2011 Authors: Van Maarseveen NM; Bernatchez JA; De Jong D; Schinazi RF; Gotte M; Nijhuis M -
Frequent incorporation of non-canonical dUTP by human immunodeficiency virus type 1 reverse transcriptase in primary human macrophage
Volume: 16 Page(s): A125 - A125
01/01/2011 Authors: Kennedy EM; Daddacha W; Slater R; Gavegnano C; Fromentin E; Schinazi RF; Kim B -
Differential impact of mutations M184V, M184I and M184T in HIV-1 RT on entecavir incorporation and susceptibility
Volume: 16 Page(s): A65 - A65
01/01/2011 Authors: van Maarseveen NM; Bernatchez JA; de Jong D; Schinazi RF; Goette M; Nijhuis M -
Synthesis and characterization of picomolar inhibitors of HCV NS5A in hepatocytes
Volume: 16 Page(s): A22 - A22
01/01/2011 Authors: Schinazi RF; Zhang H-W; Zhou L; Amblard F; Bobeck DR; Shi J; Whitaker T; McBrayer TR; Tharnish PM; Coats SJ -
Synthesis and characterization of picomolar inhibitors of HCV NS5A in hepatocytes
Volume: 16 Page(s): A22 - A22
01/01/2011 Authors: Schinazi RF; Zhang H-W; Zhou L; Amblard F; Bobeck DR; Shi J; Whitaker T; McBrayer TR; Tharnish PM; Coats SJ -
Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans.
Antivir Ther Volume: 16 Page(s): 1123 - 1130
01/01/2011 Authors: van Maarseveen NM; Wensing AM; de Jong D; Beilhartz GL; Obikhod A; Tao S; Pingen M; Arends JE; Hoepelman AI; Schinazi RF -
Chemoenzymatic syntheses and anti-HIV-1 activity of glucose-nucleoside conjugates as prodrugs.
Bioconjug Chem Volume: 21 Page(s): 2239 - 2249
12/15/2010 Authors: Rodrguez-Prez T; Fernndez S; Sanghvi YS; Detorio M; Schinazi RF; Gotor V; Ferrero M -
Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages.
J Biol Chem Volume: 285 Page(s): 39380 - 39391
12/10/2010 Authors: Kennedy EM; Gavegnano C; Nguyen L; Slater R; Lucas A; Fromentin E; Schinazi RF; Kim B -
In-vitro phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitor S/GSK1349572.
AIDS Volume: 24 Page(s): 2753 - 2755
11/13/2010 Authors: Charpentier C; Larrouy L; Collin G; Damond F; Matheron S; Chne G; Nie T; Schinazi R; Brun-Vzinet F; Descamps D -
Viral decay kinetics in the highly active antiretroviral therapy-treated rhesus macaque model of AIDS.
PLoS One Volume: 5 Page(s): e11640
07/23/2010 Authors: Deere JD; Higgins J; Cannavo E; Villalobos A; Adamson L; Fromentin E; Schinazi RF; Luciw PA; North TW -
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
Bioorg Med Chem Volume: 18 Page(s): 3261 - 3269
05/01/2010 Authors: Lin J; Roy V; Wang L; You L; Agrofoglio LA; Deville-Bonne D; McBrayer TR; Coats SJ; Schinazi RF; Eriksson S -
Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome.
PLoS One Volume: 5 Page(s): e9948
04/01/2010 Authors: Singh IR; Gorzynski JE; Drobysheva D; Bassit L; Schinazi RF -
Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.
J Nat Prod Volume: 73 Page(s): 383 - 387
03/26/2010 Authors: Na M; Ding Y; Wang B; Tekwani BL; Schinazi RF; Franzblau S; Kelly M; Stone R; Li X-C; Ferreira D -
Shape matters: Interfamily modeling of viral polymerases reveals insights for shared mechanisms of action and selectivity features
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 239
03/21/2010 Authors: Nettles JH; Schinazi RF -
Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS.
J Virol Volume: 84 Page(s): 2913 - 2922
03/01/2010 Authors: North TW; Higgins J; Deere JD; Hayes TL; Villalobos A; Adamson L; Shacklett BL; Schinazi RF; Luciw PA -
Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.
Antimicrob Agents Chemother Volume: 54 Page(s): 1248 - 1255
03/01/2010 Authors: Hurwitz SJ; Asif G; Fromentin E; Tharnish PM; Schinazi RF -
Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometry.
Anal Chem Volume: 82 Page(s): 1982 - 1989
03/01/2010 Authors: Fromentin E; Gavegnano C; Obikhod A; Schinazi RF -
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.
J Infect Dis Volume: 201 Page(s): 635 - 643
02/15/2010 Authors: Vanpouille C; Lisco A; Derudas M; Saba E; Grivel J-C; Brichacek B; Scrimieri F; Schinazi R; Schols D; McGuigan C -
HCV drug discovery aimed at viral eradication.
J Viral Hepat Volume: 17 Page(s): 77 - 90
02/01/2010 Authors: Schinazi RF; Bassit L; Gavegnano C -
The base component of 3 '-azido-2 ',3 '-dideoxynucleosides determines the mutation patterns selected in HIV-1 reverse transcriptase
Volume: 15 Page(s): A81 - A81
01/01/2010 Authors: Meteer J; Koontz D; Schinazi RF; Sluis-Cremer N; Mellors JW -
The base component of 3 '-azido-2 ',3 '-dideoxynucleosides determines the mutation patterns selected in HIV-1 reverse transcriptase
Volume: 15 Page(s): A81 - A81
01/01/2010 Authors: Meteer J; Koontz D; Schinazi RF; Sluis-Cremer N; Mellors JW -
Telbivudine-5 '-triphosphate is not a substrate for HIV-1 reverse transcriptase
Volume: 15 Page(s): A106 - A106
01/01/2010 Authors: van Maarseveen NM; Wensing AMJ; Beilhartz GL; Obikhod A; Schinazi RF; Goette M; Nijhuis M -
Telbivudine-5 '-triphosphate is not a substrate for HIV-1 reverse transcriptase
Volume: 15 Page(s): A106 - A106
01/01/2010 Authors: van Maarseveen NM; Wensing AMJ; Beilhartz GL; Obikhod A; Schinazi RF; Gotte M; Nijhuis M -
Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals.
Antivir Ther Volume: 15 Page(s): 185 - 192
01/01/2010 Authors: Murphy RL; Kivel NM; Zala C; Ochoa C; Tharnish P; Mathew J; Pascual ML; Schinazi RF -
Advances in nucleoside monophosphate prodrugs as anti-HCV agents.
Antivir Ther Volume: 15 Page(s): 935 - 950
01/01/2010 Authors: Bobeck DR; Schinazi RF; Coats SJ -
Inhibition of B virus (Macacine herpesvirus 1) by conventional and experimental antiviral compounds.
Antimicrob Agents Chemother Volume: 54 Page(s): 452 - 459
01/01/2010 Authors: Krug PW; Schinazi RF; Hilliard JK -
In vitro phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitor S/GSK1349572
Volume: 15 Page(s): A58 - A58
01/01/2010 Authors: Charpentier C; Damond F; Collin G; Larrouy L; Matheron S; Chene G; Roquebert B; Nie T; Schinazi RF; Brun-Vezinet F -
Monthly unannounced pill counts for monitoring HIV treatment adherence: tests for self-monitoring and reactivity effects.
HIV Clin Trials Volume: 11 Page(s): 325 - 331
07/23/2024 Authors: Kalichman SC; Amaral C; Swetsze C; Eaton L; Kalichman MO; Cherry C; Detorio M; Caliendo AM; Schinazi RF -
In vitro phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitor S/GSK1349572
Volume: 15 Page(s): A58 - A58
01/01/2010 Authors: Charpentier C; Damond F; Collin G; Larrouy L; Matheron S; Chene G; Roquebert B; Nie T; Schinazi RF; Brun-Vezinet F -
Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
Bioorg Med Chem Lett Volume: 20 Page(s): 60 - 64
01/01/2010 Authors: Zhang H-W; Coats SJ; Bondada L; Amblard F; Detorio M; Asif G; Fromentin E; Solomon S; Obikhod A; Whitaker T -
Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay.
J Chromatogr B Analyt Technol Biomed Life Sci Volume: 877 Page(s): 3482 - 3488
11/01/2009 Authors: Fromentin E; Asif G; Obikhod A; Hurwitz SJ; Schinazi RF -
Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
Antivir Chem Chemother Volume: 20 Page(s): 99 - 106
10/19/2009 Authors: Rondla R; Coats SJ; McBrayer TR; Grier J; Johns M; Tharnish PM; Whitaker T; Zhou L; Schinazi RF -
Antiretroviral therapy in macrophages: implication for HIV eradication.
Antivir Chem Chemother Volume: 20 Page(s): 63 - 78
10/19/2009 Authors: Gavegnano C; Schinazi RF -
Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
Eur J Med Chem Volume: 44 Page(s): 3845 - 3851
10/01/2009 Authors: Amblard F; Fromentin E; Detorio M; Obikhod A; Rapp KL; McBrayer TR; Whitaker T; Coats SJ; Schinazi RF -
Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.
J Biol Chem Volume: 284 Page(s): 26439 - 26446
09/25/2009 Authors: Tchesnokov EP; Obikhod A; Schinazi RF; Gtte M -
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrob Agents Chemother Volume: 53 Page(s): 3715 - 3719
09/01/2009 Authors: Sluis-Cremer N; Koontz D; Bassit L; Hernandez-Santiago BI; Detorio M; Rapp KL; Amblard F; Bondada L; Grier J; Coats SJ -
Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.
Antiviral Res Volume: 83 Page(s): 317 - 323
09/01/2009 Authors: Sharma PL; Nettles JH; Feldman A; Rapp K; Schinazi RF -
Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.
Chem Rev Volume: 109 Page(s): 4207 - 4220
09/01/2009 Authors: Amblard F; Cho JH; Schinazi RF -
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.
J Biol Chem Volume: 284 Page(s): 21496 - 21504
08/07/2009 Authors: Tchesnokov EP; Obikhod A; Massud I; Lisco A; Vanpouille C; Brichacek B; Balzarini J; McGuigan C; Derudas M; Margolis L -
Synthesis and antiviral activity of purine 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl nucleosides.
Nucleosides Nucleotides Nucleic Acids Volume: 28 Page(s): 519 - 536
05/01/2009 Authors: Sivets GG; Kalinichenko EN; Mikhailopulo IA; Detorio MA; McBrayer TR; Whitaker T; Schinazi RF -
Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs.
Org Biomol Chem Volume: 7 Page(s): 1415 - 1423
04/07/2009 Authors: Daz-Rodrguez A; Sanghvi YS; Fernndez S; Schinazi RF; Theodorakis EA; Ferrero M; Gotor V -
Synthesis and antiviral profiles of nucleoside analogs
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 237 Page(s): 696 - 696
03/22/2009 Authors: Liotta DC; Schinazi RF -
Preparation of ribavirin analogs by copper- and ruthenium-catalyzed azide-alkyne 1,3-dipolar cycloaddition
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 237 Page(s): 725 - 725
03/22/2009 Authors: Agrofoglio LA; Pradere U; Roy V; McBrayer TR; Schinazi RF -
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.
Cardiovasc Toxicol Volume: 9 Page(s): 1 - 12
03/01/2009 Authors: Kline ER; Bassit L; Hernandez-Santiago BI; Detorio MA; Liang B; Kleinhenz DJ; Walp ER; Dikalov S; Jones DP; Schinazi RF -
5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies.
Bioorg Med Chem Volume: 17 Page(s): 1404 - 1409
02/01/2009 Authors: Liang Y; Sharon A; Grier JP; Rapp KL; Schinazi RF; Chu CK -
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.
J Med Chem Volume: 52 Page(s): 206 - 213
01/08/2009 Authors: Kim H-J; Sharon A; Bal C; Wang J; Allu M; Huang Z; Murray MG; Bassit L; Schinazi RF; Korba B -
Development of a novel universal protocol for screening and sequencing of HIV-1 pol across clades for subtype identification and analysis of drug resistance
Volume: 14 Page(s): A129 - A129
01/01/2009 Authors: Nie T; Detorio M; Schinazi RF -
Approaches for the development of antiviral compounds: the case of hepatitis C virus.
Handb Exp Pharmacol Page(s): 25 - 51
01/01/2009 Authors: Schinazi RF; Coats SJ; Bassit LC; Lennerstrand J; Nettles JH; Hurwitz SJ -
Structure-activity-resistance relationships of 6-modified 3 '-azido-2 ',3 '-dideoxyguanosine nucleotides as inhibitors of HIV-1 reverse transcriptase
Volume: 14 Page(s): A144 - A144
01/01/2009 Authors: Herman BD; Obikhod A; Detorio M; Zhang H-W; Nettles J; Coats SJ; Schinazi RF; Mellors JW; Sluis-Cremer N -
HIV-1 nucleoside analogue triphosphate levels are significantly lower in primary human macrophages than in human lymphocytes
Volume: 14 Page(s): A98 - A98
01/01/2009 Authors: Gavegnano C; Fromentin E; Schinazi RF -
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase
Volume: 14 Page(s): A21 - A21
01/01/2009 Authors: Tchesnokov EP; Obikhod A; Massud I; Lisco A; Vanpouille C; Brichacek B; Balzarini J; McGuigan C; Derudas M; Margolis L -
Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.
J Biol Chem Volume: 283 Page(s): 34218 - 34228
12/05/2008 Authors: Tchesnokov EP; Obikhod A; Schinazi RF; Gtte M -
Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model.
Antimicrob Agents Chemother Volume: 52 Page(s): 4241 - 4250
12/01/2008 Authors: Hurwitz SJ; Asif G; Kivel NM; Schinazi RF -
Preparation of ribavirin analogues by copper- and ruthenium-catalyzed azide-alkyne 1,3-dipolar cycloaddition.
Tetrahedron Volume: 64 Page(s): 9044 - 9051
09/15/2008 Authors: Pradere U; Roy V; McBrayer TR; Schinazi RF; Agrofoglio LA -
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.
Cell Host Microbe Volume: 4 Page(s): 260 - 270
09/11/2008 Authors: Lisco A; Vanpouille C; Tchesnokov EP; Grivel J-C; Biancotto A; Brichacek B; Elliott J; Fromentin E; Shattock R; Anton P -
Anti-infective pyrroloiminoquinone alkaloids from a deep-water Alaskan sponge of the genus Latrunculia
Volume: 74 Page(s): 1037 - 1037
07/01/2008 Authors: Na MK; Schinazi RF; Kelly M; Stone R; Hamann MT -
Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT.
Tetrahedron Volume: 64 Page(s): 4444 - 4452
05/01/2008 Authors: Joubert N; Amblard F; Rapp KL; Schinazi RF; Agrofoglio LA -
MEDI 321-Antiinfective secondary metabolites from marine sponges and microorganisms
Volume: 235
04/06/2008 Authors: Na M; Meujo DAF; Kevin D; Anderson M; Hill RT; Schinazi RF; Hamann MT -
Effects of HIV-1 on Endothelial Gene Expression
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Porter KM; Detorio M; Schinazi RF; Sutliff RL -
Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon vs interferon.
J Viral Hepat Volume: 15 Page(s): 314 - 321
04/01/2008 Authors: Yurdaydin C; Bozkaya H; Onder FO; Sentrk H; Karaaslan H; Akdoan M; Cetinkaya H; Erden E; Erkan-Esin O; Yalin K -
Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine.
Chem Biol Drug Des Volume: 71 Page(s): 205 - 215
03/01/2008 Authors: Bowling JJ; Pennaka HK; Ivey K; Wahyuono S; Kelly M; Schinazi RF; Valeriote FA; Graves DE; Hamann MT -
Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.
J Biol Chem Volume: 283 Page(s): 5452 - 5459
02/29/2008 Authors: Domaoal RA; McMahon M; Thio CL; Bailey CM; Tirado-Rives J; Obikhod A; Detorio M; Rapp KL; Siliciano RF; Schinazi RF -
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.
PLoS Med Volume: 5 Page(s): e28
02/01/2008 Authors: Garca-Lerma JG; Otten RA; Qari SH; Jackson E; Cong M-E; Masciotra S; Luo W; Kim C; Adams DR; Monsour M -
1-Benzyl-2-(1H-indol-3-yl)-5-oxo-pyrrolidine-2-carbonitrile.
Acta Crystallogr Sect E Struct Rep Online Volume: 64 Page(s): o368
01/04/2008 Authors: Tamazyan R; Armen A; Ashot M; Sahak G; Schinazi R -
Novel resistance profile of the potent nucleoside analogue reverse transcriptase inhibitor 3 '-azido-2 ',3 '-dideoxyguanosine
Volume: 13 Page(s): A5 - A5
01/01/2008 Authors: Meteer J; Koontz D; Rapp KL; Detorio M; Ruckstuhl M; Schinazi RF; Mellors JW -
Intracellular factors that decrease HIV-1 RNase H activity and increase the rate of zidovudine 5 '-monophosphate excision studied for RNA and DNA template dependency
Volume: 13 Page(s): A57 - A57
01/01/2008 Authors: Malmsten A; Bennett M; Orenstein E; Bluemling GR; Ruckstuhl M; Schinazi RF; Lennerstrand J -
Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system.
Antivir Chem Chemother Volume: 19 Page(s): 25 - 31
01/01/2008 Authors: Bassit L; Grier J; Bennett M; Schinazi RF -
Delayed chain-termination protects the hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase
Volume: 13 Page(s): A48 - A48
01/01/2008 Authors: Tchesnokov E; Obikhod A; Schinazi RF; Gotte M -
Monitoring medication adherence by unannounced pill counts conducted by telephone: reliability and criterion-related validity.
HIV Clin Trials Volume: 9 Page(s): 298 - 308
01/01/2008 Authors: Kalichman SC; Amaral CM; Cherry C; Flanagan J; Pope H; Eaton L; Kalichman MO; Cain D; Detorio M; Caliendo A -
Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.
Antiviral Res Volume: 75 Page(s): 198 - 209
09/01/2007 Authors: Narayanasamy J; Pullagurla MR; Sharon A; Wang J; Schinazi RF; Chu CK -
Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection.
Antimicrob Agents Chemother Volume: 51 Page(s): 3177 - 3184
09/01/2007 Authors: Menne S; Asif G; Narayanasamy J; Butler SD; George AL; Hurwitz SJ; Schinazi RF; Chu CK; Cote PJ; Gerin JL -
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
Bioorg Med Chem Lett Volume: 17 Page(s): 4428 - 4431
08/15/2007 Authors: Amblard F; Govindarajan B; Lefkove B; Rapp KL; Detorio M; Arbiser JL; Schinazi RF -
Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 51 Page(s): 2877 - 2882
08/01/2007 Authors: Asif G; Hurwitz SJ; Shi J; Hernandez-Santiago BI; Schinazi RF -
Prevention of rectal SHIV transmission in macaques by FTC or tenofovir/FTC combination
JOURNAL OF MEDICAL PRIMATOLOGY Volume: 36 Page(s): 302 - 303
08/01/2007 Authors: Garcia-Lerma JG; Otten R; Qari S; Jackson E; Cong M-E; Masciotra S; Lipscomb J; Johnson J; Luo W; Kim C -
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 51 Page(s): 2424 - 2429
07/01/2007 Authors: Asif G; Hurwitz SJ; Obikhod A; Delinsky D; Narayanasamy J; Chu CK; McClure HM; Schinazi RF -
Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents.
Bioorg Med Chem Lett Volume: 17 Page(s): 3398 - 3401
06/15/2007 Authors: Li Y; Mao S; Hager MW; Becnel KD; Schinazi RF; Liotta DC -
Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine.
Antimicrob Agents Chemother Volume: 51 Page(s): 2130 - 2135
06/01/2007 Authors: Hernandez-Santiago BI; Mathew JS; Rapp KL; Grier JP; Schinazi RF -
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.
Antimicrob Agents Chemother Volume: 51 Page(s): 2078 - 2084
06/01/2007 Authors: Lennerstrand J; Chu CK; Schinazi RF -
7-deaza neplanocin analogs inhibit hepatitis C virus (HCV) in vitro
Volume: 74 Page(s): A49 - A49
06/01/2007 Authors: Kim HJ; Wang JN; Huang ZH; Murray MG; Schinazi RF; Chu CK -
Preclinical and clinical development of the anti-HIV, anti-HBV oxathiolane nucleoside analog emtricitabine
Frontiers in Viral Hepatitis Volume: 2003 Page(s): 451 - 484
05/09/2007 Authors: Schinazi RF; Painter GR; Rimsky LT; Furman PA; Liotta DC; Quinn JB -
D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.
J Med Chem Volume: 50 Page(s): 1828 - 1839
04/19/2007 Authors: Wang J; Jin Y; Rapp KL; Schinazi RF; Chu CK -
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
Bioorg Med Chem Volume: 15 Page(s): 1212 - 1228
02/01/2007 Authors: Patil S; Kamath S; Sanchez T; Neamati N; Schinazi RF; Buolamwini JK -
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Antimicrob Agents Chemother Volume: 51 Page(s): 503 - 509
02/01/2007 Authors: Murakami E; Bao H; Ramesh M; McBrayer TR; Whitaker T; Micolochick Steuer HM; Schinazi RF; Stuyver LJ; Obikhod A; Otto MJ -
Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.
Bioorg Med Chem Volume: 15 Page(s): 839 - 846
01/15/2007 Authors: Rao JR; Schinazi RF; Chu CK -
Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
Nucleosides Nucleotides Nucleic Acids Volume: 26 Page(s): 83 - 97
01/01/2007 Authors: Chun B-K; Wang P; Hassan A; Du J; Tharnish PM; Murakami E; Stuyver L; Otto MJ; Schinazi RF; Watanabe KA -
Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma.
Antivir Chem Chemother Volume: 18 Page(s): 25 - 33
01/01/2007 Authors: Ray AS; Feng JY; Murakami E; Chu CK; Schinazi RF; Anderson KS -
Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes.
Antivir Chem Chemother Volume: 18 Page(s): 343 - 346
01/01/2007 Authors: Hernandez-Santiago BI; Obikhod A; Fromentin E; Hurwitz SJ; Schinazi RF -
Development of a novel mouse model to evaluate drug candidates against hepatitis B virus.
Antivir Chem Chemother Volume: 18 Page(s): 213 - 223
01/01/2007 Authors: Feitelson MA; Clayton MM; Sun B; Schinazi RF -
Development of a population simulation model for HIV monotherapy virological outcomes using lamivudine.
Antivir Chem Chemother Volume: 18 Page(s): 329 - 341
01/01/2007 Authors: Hurwitz SJ; Asif G; Schinazi RF -
The combination of zidovudine and amdoxovir prevents the selection of thymidine analogue mutations in primary human lymphocytes
Volume: 12 Page(s): S130 - S130
01/01/2007 Authors: Rapp KL; Ruckstuhl M; Schinazi RF -
Characterization of a novel S68 deletion in HIV-1 reverse transcriptase
Volume: 12 Page(s): S27 - S27
01/01/2007 Authors: Schinazi RF; Ruckstuhl M; Rapp KL; Lennerstrand J; Bennett M; Detorio M -
Combinations of 2'-methylcytidine analogs with interferon alpha-2b lead to synergistic inhibition of hepatitis C virus replication in a replicon system
Volume: 46 Page(s): S217 - S217
01/01/2007 Authors: Bassit L; Grier J; Bennett M; Schinazi RF -
Characterization of the Q151M and V1111 mutations of HIV-2 reverse transcriptase
Volume: 12 Page(s): S120 - S120
01/01/2007 Authors: Bennett M; Detorio M; Lennerstrand J; Brun-Vezinet F; Descamps D; Schinazi RF -
Characterization of the Q151M and V111I mutations of HIV-2 reverse transcriptase
Volume: 12 Page(s): S120 - S120
01/01/2007 Authors: Bennet M; Detorio M; Lennerstrand J; Brun-Vezinet F; Descamps D; Schinazi RF -
Anti-HCV activity and cellular pharmacology of 2 '-methyleytidine alone and in combination with non-toxic concentrations of ribavirin in the HCV replicon system
Volume: 12 Page(s): S28 - S28
01/01/2007 Authors: Hernandez-Santiago BI; Bassit L; Grier J; Schinazi RF -
The combination of zidovudine and amdoxovir prevents the selection of thymidine analogue mutations in primary human lymphocytes
Volume: 12 Page(s): S130 - S130
01/01/2007 Authors: Rapp KL; Ruckstuhl M; Schinazi RF -
Anti-HCV activity and cellular pharmacology of 2'-methylcytidine alone and in combination with non-toxic concentrations of ribavirin in the HCV replicon system
Volume: 12 Page(s): S28 - S28
01/01/2007 Authors: Hernandez-Santiago BI; Bassit L; Grier J; Schinazi RF -
Characterization of a novel S68 deletion in HIV-1 reverse transcriptase
Volume: 12 Page(s): S27 - S27
01/01/2007 Authors: Schinazi RF; Ruckstuhl M; Rapp KL; Lennerstrand J; Bennett M; Detorio M -
Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity.
Bioorg Med Chem Volume: 14 Page(s): 8495 - 8505
12/15/2006 Authors: Gul W; Hammond NL; Yousaf M; Bowling JJ; Schinazi RF; Wirtz SS; de Castro Andrews G; Cuevas C; Hamann MT -
Synthesis of neplanocin F analogues as potential antiviral agents.
Bioorg Med Chem Volume: 14 Page(s): 8314 - 8322
12/15/2006 Authors: Zhang H; Schinazi RF; Chu CK -
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Cancer Chemother Pharmacol Volume: 58 Page(s): 692 - 698
11/01/2006 Authors: Al Safarjalani ON; Rais R; Shi J; Schinazi RF; Naguib FNM; el Kouni MH -
MEDI 235-L-3,6-dioxa-[3.2.0]bicyclonucleosides: Synthesis and biological evaluation
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 232
09/10/2006 Authors: Fang X; Schinazi RF; Liotta DC -
MEDI 244-Design, synthesis and antiviral activity of cyclobutyl phosphonate nucleoside analogs as chain terminators against HIV
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 232
09/10/2006 Authors: Li Y; Schinazi RF; Liotta DC -
Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses.
Antiviral Res Volume: 71 Page(s): 322 - 334
09/01/2006 Authors: Schinazi RF; Hernandez-Santiago BI; Hurwitz SJ -
Drug-drug interaction between clevudine in combination with telbivudine or 3TC in human liver cells
Volume: 36 Page(s): S56 - S56
07/01/2006 Authors: Hernandez-Santiago BI; Delinsky DC; Schinazi RF -
Prevalence of hepatitis B and C in Constantine in 2005
Volume: 36 Page(s): S214 - S214
07/01/2006 Authors: Semra Z; Kaki BA; Smati F; Semra D; Amri K -
Facile purification of honokiol and its antiviral and cytotoxic properties.
J Med Chem Volume: 49 Page(s): 3426 - 3427
06/01/2006 Authors: Amblard F; Delinsky D; Arbiser JL; Schinazi RF -
Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.
Bioorg Med Chem Volume: 14 Page(s): 2178 - 2189
04/01/2006 Authors: Liang Y; Narayanasamy J; Schinazi RF; Chu CK -
Synthesis and antiviral activity of L-3'-fluoro-2',3'-unsaturated carbocyclic nucleosides
Volume: 231
03/26/2006 Authors: Wang J; Jin Y; Schinazi RF; Chu CK -
Synthesis of 4'-C-methylcarbocyclic nucleosides via conjugate addition of D-4-methylcyclopentenone
Volume: 231
03/26/2006 Authors: Liu P; Schinazi RF; Chu CK -
Honokiol and Magnolol: New potent antitumor compounds
Volume: 231
03/26/2006 Authors: Amblard F; Delinsky D; Arbiser JL; Schinazi RF -
3'-Deoxy-3',4'-unsaturated carbocyclic nucleosides: Synthesis of neplanocin F analogs
Volume: 231
03/26/2006 Authors: Zhang H; Schinazi RF; Chu CK -
Synthesis and anti-HIV activity of DAPD (Amdoxovir) prodrugs in vitro against M184 HIV mutant
Volume: 231
03/26/2006 Authors: Narayanasamy J; Sharon A; Pullagurla MR; Schinazi RF; Chu CK -
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.
Bioorg Med Chem Lett Volume: 16 Page(s): 1712 - 1715
03/15/2006 Authors: Clark JL; Mason JC; Hollecker L; Stuyver LJ; Tharnish PM; McBrayer TR; Otto MJ; Furman PA; Schinazi RF; Watanabe KA -
Synthesis and anti-HIV activity of D- and L-thietanose nucleosides.
J Med Chem Volume: 49 Page(s): 1635 - 1647
03/09/2006 Authors: Choo H; Chen X; Yadav V; Wang J; Schinazi RF; Chu CK -
PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.
Antivir Chem Chemother Volume: 17 Page(s): 321 - 329
01/01/2006 Authors: Liang Y; Narayanasamy J; Rapp KL; Schinazi RF; Chu CK -
Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
Antivir Chem Chemother Volume: 17 Page(s): 79 - 87
01/01/2006 Authors: Stuyver LJ; McBrayer TR; Tharnish PM; Clark J; Hollecker L; Lostia S; Nachman T; Grier J; Bennett MA; Xie M-Y -
AZT-MP and magnesium dependency for AZT resistance studied with reverse transcriptase bearing TAMs
Volume: 11 Page(s): S156 - S156
01/01/2006 Authors: Lennerstrand J; Bennett M; Bluemling GR; Ruckstuhl M; Schinazi RF -
Prevention of rectal SHIV transmission in macaques by tenofovir/FTC combination
Volume: 11 Page(s): S107 - S107
01/01/2006 Authors: Garcia-Lerma JG; Otten R; Qari S; Jackson E; Luo W; Kim C; Adams D; Bashirian S; Monsour M; Delinsky D -
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.
Bioorg Med Chem Volume: 13 Page(s): 6015 - 6024
11/01/2005 Authors: Escuret V; Aucagne V; Joubert N; Durantel D; Rapp KL; Schinazi RF; Zoulim F; Agrofoglio LA -
Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.
J Med Chem Volume: 48 Page(s): 6454 - 6460
10/06/2005 Authors: Wang P; Du J; Rachakonda S; Chun B-K; Tharnish PM; Stuyver LJ; Otto MJ; Schinazi RF; Watanabe KA -
Treatment of chronic hepatitis D (CHD) with interferon vs. interferon plus lamivudine vs. lamivudine: Short-and long-term results
Volume: 42 Page(s): 724A - 725A
10/01/2005 Authors: Yurdaydin C; Bozkaya H; Onder O; Senturk H; Fried M; Idilman R; Cetinkaya H; Schinazi R; Bozdayi MA; Uzunalimoglu O -
The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells.
J Neurooncol Volume: 74 Page(s): 275 - 280
09/01/2005 Authors: Moore C; Hernndez-Santiago BI; Hurwitz SJ; Tan C; Wang C; Schinazi RF -
In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.
Antimicrob Agents Chemother Volume: 49 Page(s): 3930 - 3932
09/01/2005 Authors: Hammond JL; Parikh UM; Koontz DL; Schlueter-Wirtz S; Chu CK; Bazmi HZ; Schinazi RF; Mellors JW -
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.
J Clin Invest Volume: 115 Page(s): 2534 - 2545
09/01/2005 Authors: Williams K; Westmoreland S; Greco J; Ratai E; Lentz M; Kim W-K; Fuller RA; Kim JP; Autissier P; Sehgal PK -
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.
J Med Chem Volume: 48 Page(s): 5504 - 5508
08/25/2005 Authors: Clark JL; Hollecker L; Mason JC; Stuyver LJ; Tharnish PM; Lostia S; McBrayer TR; Schinazi RF; Watanabe KA; Otto MJ -
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.
J Biol Chem Volume: 280 Page(s): 29047 - 29052
08/12/2005 Authors: Sluis-Cremer N; Arion D; Parikh U; Koontz D; Schinazi RF; Mellors JW; Parniak MA -
Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1.
Antimicrob Agents Chemother Volume: 49 Page(s): 3334 - 3340
08/01/2005 Authors: Moser MJ; Ruckstuhl M; Larsen CA; Swearingen AJ; Kozlowski M; Bassit L; Sharma PL; Schinazi RF; Prudent JR -
Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates.
Bioorg Med Chem Volume: 13 Page(s): 4168 - 4175
07/01/2005 Authors: Lenikowski ZJ; Paradowska E; Olejniczak AB; Studziska M; Seekamp P; Schssler U; Gabel D; Schinazi RF; Plesek J -
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-nave human immunodeficiency virus-infected patients.
Antimicrob Agents Chemother Volume: 49 Page(s): 2828 - 2833
07/01/2005 Authors: Herzmann C; Arasth K; Murphy RL; Schulbin H; Kreckel P; Drauz D; Schinazi RF; Beard A; Cartee L; Otto MJ -
Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.
Antimicrob Agents Chemother Volume: 49 Page(s): 2618 - 2624
07/01/2005 Authors: Pai SB; Bozdayi AM; Pai RB; Beker T; Sarioglu M; Turkyilmaz AR; Grier J; Yurdaydin C; Schinazi RF -
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Antimicrob Agents Chemother Volume: 49 Page(s): 2589 - 2597
07/01/2005 Authors: Hernandez-Santiago BI; Chen H; Asif G; Beltran T; Mao S; Hurwitz SJ; Grier J; McClure HM; Chu CK; Liotta DC -
Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism.
J Med Chem Volume: 48 Page(s): 3949 - 3952
06/16/2005 Authors: Chu CK; Yadav V; Chong YH; Schinazi RF -
ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.
Biochim Biophys Acta Volume: 1712 Page(s): 81 - 91
06/15/2005 Authors: Rossi S; Schinazi RF; Martini G -
Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.
J Med Chem Volume: 48 Page(s): 3736 - 3748
06/02/2005 Authors: Wang J; Jin Y; Rapp KL; Bennett M; Schinazi RF; Chu CK -
5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens.
Cancer Chemother Pharmacol Volume: 55 Page(s): 541 - 551
06/01/2005 Authors: Al Safarjalani ON; Zhou X-J; Rais RH; Shi J; Schinazi RF; Naguib FNM; El Kouni MH -
Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.
J Virol Volume: 79 Page(s): 7349 - 7354
06/01/2005 Authors: North TW; Van Rompay KKA; Higgins J; Matthews TB; Wadford DA; Pedersen NC; Schinazi RF -
Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.
Antimicrob Agents Chemother Volume: 49 Page(s): 1994 - 2001
05/01/2005 Authors: Ray AS; Hernandez-Santiago BI; Mathew JS; Murakami E; Bozeman C; Xie M-Y; Dutschman GE; Gullen E; Yang Z; Hurwitz S -
Synthesis and biological evaluation of 3,6-dioxa-[3,2,0]bicyclonucleosides.
Volume: 229 Page(s): U187 - U187
03/13/2005 Authors: Fang XG; Schinazi RF; Liotta DC -
Synthesis of novel cyclobutyl nucleoside analogs.
Volume: 229 Page(s): U188 - U188
03/13/2005 Authors: Li YF; Mao SL; Hager MW; Liotta DC; Schinazi RF -
Synthesis and anti-HIV activity of beta-D-3 '-azido-2 ',3 '-unsaturated nucleosides and beta-D-3 '-azido-3 '-deoxyribofuranosylnucleosides
Volume: 229 Page(s): U260 - U260
03/13/2005 Authors: Gadthula S; Schinazi RF; Chu CK -
Prodrugs of 1-(beta-d-dioxolane)thymine (DOT): Synthesis, anti-HIV-1 activity and stability study.
Volume: 229 Page(s): U168 - U168
03/13/2005 Authors: Liang YZ; Yadav V; Schinazi RF; Chu CK -
Synthesis of N3,5 '-cyclo-4-(beta-D-ribofuranosyl)-vic-tria-zolo[4,5-b]pyridin-5-one analogues with improved anti-hepatitis C activity in vitro.
Volume: 229 Page(s): U171 - U171
03/13/2005 Authors: Wang PY; Du DF; Rachakonda S; Chun BK; Stuyver LJ; Otto MJ; Schinazi RF; Watanabe KA -
Dioxolane-thymine nucleoside is active against a variety of clinically relevant NRTI drug resistant HIV-1 strains
Volume: 65 Page(s): A29 - A29
03/01/2005 Authors: Chu CK; Yadav V; Rapp KL; Detorio M; Schinazi RF -
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase.
Antimicrob Agents Chemother Volume: 49 Page(s): 1139 - 1144
03/01/2005 Authors: Parikh UM; Koontz DL; Chu CK; Schinazi RF; Mellors JW -
Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.
Bioorg Med Chem Volume: 13 Page(s): 1641 - 1652
03/01/2005 Authors: Shi J; Du J; Ma T; Pankiewicz KW; Patterson SE; Tharnish PM; McBrayer TR; Stuyver LJ; Otto MJ; Chu CK -
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.
Bioorg Med Chem Volume: 13 Page(s): 1239 - 1248
02/15/2005 Authors: Amblard F; Aucagne V; Guenot P; Schinazi RF; Agrofoglio LA -
Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 49 Page(s): 560 - 564
02/01/2005 Authors: Asif G; Hurwitz SJ; Gumina G; Chu CK; McClure HM; Schinazi RF -
Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha.
Nat Prod Res Volume: 19 Page(s): 177 - 182
02/01/2005 Authors: Likhitwitayawuid K; Sritularak B; Benchanak K; Lipipun V; Mathew J; Schinazi RF -
5 ',9-anhydro-3-(beta-D-ribofuranosyl)purine nucleoside analogues as potential anti-HCV agents
Volume: 7 Page(s): 319 - 327
01/01/2005 Authors: Chun BK; Clark JL; Du J; Furman PA; Hassan AE; Hollecker L; McBrayer T; Otto ME; Pankiewicz KW; Patterson SE -
Effects of M184V mutation in multi-dideoxynucleoside analog resistant HIV-1 reverse transcriptase on removal of beta-D-dioxolane-guanine monophosphate from blocked primer
Volume: 10 Page(s): S79 - S79
01/01/2005 Authors: Lennerstrand J; Espili NH; Pavlova A; Chu CK; Asif G; Schinazi RF -
A promising method for mixed population genotyping of drug-resistant HIV-1
Volume: 10 Page(s): S43 - S43
01/01/2005 Authors: Moser MJ; Beaty EL; Ruckstuhl M; Kozlowski M; Schinazi RF; Prudent JR -
Retrovirus reverse transcriptases containing a modified YXDD motif.
Antivir Chem Chemother Volume: 16 Page(s): 169 - 182
01/01/2005 Authors: Sharma PL; Nurpeisov V; Schinazi RF -
Effects of M184V mutation in multi-dideoxynucleoside analog resistant HIV-1 reverse transcriptase on removal of beta-D-dioxolane-guanine monophosphate from blocked primer
Volume: 10 Page(s): S79 - S79
01/01/2005 Authors: Lennerstrand J; Espili NH; Pavlova A; Chu CK; Asif G; Schinazi RF -
Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans.
Antivir Chem Chemother Volume: 16 Page(s): 117 - 127
01/01/2005 Authors: Hurwitz SJ; Otto MJ; Schinazi RF -
1-(beta-D-Dioxolane)thymine (DOT) is a TK-dependent orally bioavailable nucleoside with specific activity against HIV-1 resistant variants
Volume: 10 Page(s): S65 - S65
01/01/2005 Authors: Schinazi RF; Asif G; Detorio M; Hernandez-Santiago B; Ruckstuhl M; Yadav V; Rapp KL; Bennett M; Grier J; Xie MY -
1-(beta-D-dioxolane)thymine (DOT) is a TK-dependent orally bioavailable nucleoside with specific activity against HIV-1 resistant variants
Volume: 10 Page(s): S65 - S65
01/01/2005 Authors: Schinazi RF; Asif G; Detorio M; Hernandez-Santiago B; Ruckstuhl M; Yadav V; Rapp KL; Bennett M; Grier J; Xie MY -
A promising method for mixed population genotyping of drug-resistant HIV-1
Volume: 10 Page(s): S43 - S43
01/01/2005 Authors: Moser MJ; Beaty EL; Ruckstuhl M; Kozlowski M; Schinazi RF; Prudent JR -
Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides.
Antivir Chem Chemother Volume: 16 Page(s): 183 - 192
01/01/2005 Authors: Pai SB; Pai RB; Xie M-Y; Beker T; Shi J; Tharnish PM; Chu CK; Schinazi RF -
N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.
Nucleosides Nucleotides Nucleic Acids Volume: 24 Page(s): 1209 - 1214
01/01/2005 Authors: Du J; Hollecker L; Shi J; Chun B-K; Watanabe KA; Raymond FS; Nachman TY; Lostia S; Stuyver LJ; Otto MJ -
Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives.
Nucleosides Nucleotides Nucleic Acids Volume: 24 Page(s): 1531 - 1542
01/01/2005 Authors: Hassan AEA; Wang P; McBrayer T; Tharnish P; Stuyver L; Otto MJ; Watanabe KA; Schinazi RF -
Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides.
Nucleosides Nucleotides Nucleic Acids Volume: 24 Page(s): 1707 - 1727
01/01/2005 Authors: Gadthula S; Chu CK; Schinazi RF -
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.
Nucleosides Nucleotides Nucleic Acids Volume: 24 Page(s): 957 - 960
01/01/2005 Authors: Wang P; Hollecker L; Pankiewicz KW; Patterson SE; Whitaker T; McBrayer TR; Tharnish PM; Stuyver LJ; Schinazi RF; Otto MJ -
Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.
Nucleosides Nucleotides Nucleic Acids Volume: 24 Page(s): 875 - 879
01/01/2005 Authors: Shi J; Du J; Ma T; Pankiewicz KW; Patterson SE; Hassan AEA; Tharnish PM; McBrayer TR; Lostia S; Stuyver LJ -
Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.
Nucleosides Nucleotides Nucleic Acids Volume: 24 Page(s): 961 - 964
01/01/2005 Authors: Hassan AEA; Wang P; McBrayer TR; Tharnish PM; Stuyver LJ; Schinazi RF; Otto MJ; Watanabe KA -
Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells.
Antimicrob Agents Chemother Volume: 48 Page(s): 4636 - 4642
12/01/2004 Authors: Hernandez-Santiago BI; Beltran T; Stuyver L; Chu CK; Schinazi RF -
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.
J Med Chem Volume: 47 Page(s): 6100 - 6103
11/18/2004 Authors: Wang P; Hollecker L; Pankiewicz KW; Patterson SE; Whitaker T; McBrayer TR; Tharnish PM; Sidwell RW; Stuyver LJ; Otto MJ -
Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection.
Volume: 127 Page(s): S283 - S293
11/01/2004 Authors: Tennant BC; Toshkov IA; Peek SF; Jacob JR; Menne S; Hornbuckle WE; Schinazi RD; Korba BE; Cote PJ; Gerin JL -
Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent.
Bioorg Med Chem Lett Volume: 14 Page(s): 4991 - 4994
10/04/2004 Authors: Mao S; Bouygues M; Welch C; Biba M; Chilenski J; Schinazi RF; Liotta DC -
Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.
J Org Chem Volume: 69 Page(s): 6034 - 6041
09/03/2004 Authors: Chen X; Zhou W; Schinazi RF; Chu CK -
Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.
Antimicrob Agents Chemother Volume: 48 Page(s): 3483 - 3490
09/01/2004 Authors: Hofman MJ; Higgins J; Matthews TB; Pedersen NC; Tan C; Schinazi RF; North TW -
Synthesis of 3 '-fluoro-4 '-ethynyl-2 ',3 '-unsaturated D- and L-nucleosides.
Volume: 228 Page(s): U222 - U222
08/22/2004 Authors: Chen X; Zhou W; Schinazi RF; Chu CK -
Enantiomeric synthesis of carbocyclic D-6-azapyrimidine ribofuranucleosides.
Volume: 228 Page(s): U221 - U221
08/22/2004 Authors: Chu CK; Liu P; Schinazi RF -
Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.
J Nat Prod Volume: 67 Page(s): 1314 - 1318
08/01/2004 Authors: Rao KV; Kasanah N; Wahyuono S; Tekwani BL; Schinazi RF; Hamann MT -
Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.
Antivir Ther Volume: 9 Page(s): 529 - 536
08/01/2004 Authors: Stuyver LJ; McBrayer TR; Schrmann D; Kravec I; Beard A; Cartee L; Schinazi RF; De La Rosa A; Murphy RL; Otto MJ -
Dioxolane-thymine nucleoside (DOT) against drug-resistant HIV-1 mutants and its molecular mechanism
Volume: 9 Page(s): U30 - U31
08/01/2004 Authors: Chu CK; Chong YH; Schinazi RF -
Synthesis of novel spiro[2.3]hexane carbocyclic nucleosides via enzymatic resolution.
Org Lett Volume: 6 Page(s): 2531 - 2534
07/22/2004 Authors: Bondada L; Gumina G; Nair R; Ning XH; Schinazi RF; Chu CK -
Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents.
J Med Chem Volume: 47 Page(s): 3399 - 3408
06/17/2004 Authors: Zhou W; Gumina G; Chong Y; Wang J; Schinazi RF; Chu CK -
2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.
Bioorg Med Chem Lett Volume: 14 Page(s): 2159 - 2162
05/03/2004 Authors: Shi J; Ray AS; Mathew JS; Anderson KS; Chu CK; Schinazi RF -
Mechanism of anti-HIV activity of dioxolane nuelcosides against 3TC-resistant HIV-1 reverse transcriptase-molecular modeling approach
Volume: 62 Page(s): A42 - A42
05/01/2004 Authors: Chu CK; Schinazi RF; Chong YH -
Replication-dependent 65R-->K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V.
Virology Volume: 321 Page(s): 222 - 234
04/10/2004 Authors: Sharma PL; Nurpeisov V; Lee K; Skaggs S; Di San Filippo CA; Schinazi RF -
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.
Antiviral Res Volume: 62 Page(s): 57 - 64
04/01/2004 Authors: Murakami E; Ray AS; Schinazi RF; Anderson KS -
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
Curr Med Chem Volume: 11 Page(s): 887 - 900
04/01/2004 Authors: Pankiewicz KW; Patterson SE; Black PL; Jayaram HN; Risal D; Goldstein BM; Stuyver LJ; Schinazi RF -
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
Antimicrob Agents Chemother Volume: 48 Page(s): 1300 - 1306
04/01/2004 Authors: Feng JY; Murakami E; Zorca SM; Johnson AA; Johnson KA; Schinazi RF; Furman PA; Anderson KS -
Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.
J Med Chem Volume: 47 Page(s): 1631 - 1640
03/25/2004 Authors: Zhu W; Chong Y; Choo H; Mathews J; Schinazi RF; Chu CK -
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.
Antimicrob Agents Chemother Volume: 48 Page(s): 651 - 654
02/01/2004 Authors: Stuyver LJ; McBrayer TR; Whitaker T; Tharnish PM; Ramesh M; Lostia S; Cartee L; Shi J; Hobbs A; Schinazi RF -
Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
Curr Top Med Chem Volume: 4 Page(s): 895 - 919
01/01/2004 Authors: Sharma PL; Nurpeisov V; Hernandez-Santiago B; Beltran T; Schinazi RF -
Hepatitis B virus transgenic severe combined immunodeficient mouse model of acute and chronic liver disease.
Methods Mol Med Volume: 96 Page(s): 269 - 287
01/01/2004 Authors: Feitelson MA; Larkin JD; Schinazi RF -
Tissue disposition of 5-o-carboranyluracil--a novel agent for the boron neutron capture therapy of prostate cancer.
Nucleosides Nucleotides Nucleic Acids Volume: 23 Page(s): 291 - 306
01/01/2004 Authors: Schinazi RF; Hurwitz SJ; Liberman I; Glazkova Y; Mourier NS; Olson J; Keane T -
Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture.
Antivir Chem Chemother Volume: 15 Page(s): 43 - 55
01/01/2004 Authors: Hollecker L; Choo H; Chong Y; Chu CK; Lostia S; McBrayer TR; Stuyver LJ; Mason JC; Du J; Rachakonda S -
Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.
J Am Chem Soc Volume: 125 Page(s): 13382 - 13386
11/05/2003 Authors: Peng J; Hu J-F; Kazi AB; Li Z; Avery M; Peraud O; Hill RT; Franzblau SG; Zhang F; Schinazi RF -
Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach.
Antivir Chem Chemother Volume: 14 Page(s): 309 - 319
11/01/2003 Authors: Chong Y; Stuyver L; Otto MJ; Schinazi RF; Chu CK -
Assessment of the relative potency of emtricitabine and lamivudine.
J Acquir Immune Defic Syndr Volume: 34 Page(s): 243 - 245
10/01/2003 Authors: Schinazi RF -
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.
J Virol Volume: 77 Page(s): 10689 - 10694
10/01/2003 Authors: Stuyver LJ; McBrayer TR; Tharnish PM; Hassan AEA; Chu CK; Pankiewicz KW; Watanabe KA; Schinazi RF; Otto MJ -
Treatment modalities for hepatitis B viral infection and resistance to antiviral therapy.
Panminerva Med Volume: 45 Page(s): 165 - 173
09/01/2003 Authors: Pai SB; Pai RB; Schinazi RF -
Synthesis and biological evaluation of 5-carboxamido-2 ',3 '-dideoxy-3 '-oxacytidine.
Volume: 226 Page(s): U23 - U23
09/01/2003 Authors: Fang XG; Schinazi RF; Liotta DC -
Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.
Bioorg Med Chem Volume: 11 Page(s): 3633 - 3639
08/15/2003 Authors: Saito Y; Escuret V; Durantel D; Zoulim F; Schinazi RF; Agrofoglio LA -
Marine natural products as lead anti-HIV agents.
Mini Rev Med Chem Volume: 3 Page(s): 401 - 424
08/01/2003 Authors: Gochfeld DJ; El Sayed KA; Yousaf M; Hu JF; Bartyzel P; Dunbar DC; Wilkins SP; Zjawiony JK; Schinazi RF; Schlueter Wirtz S -
Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis.
Biochemistry Volume: 42 Page(s): 8831 - 8841
07/29/2003 Authors: Ray AS; Murakami E; Basavapathruni A; Vaccaro JA; Ulrich D; Chu CK; Schinazi RF; Anderson KS -
l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.
J Med Chem Volume: 46 Page(s): 3245 - 3256
07/17/2003 Authors: Chong Y; Gumina G; Mathew JS; Schinazi RF; Chu CK -
YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine.
J Viral Hepat Volume: 10 Page(s): 256 - 265
07/01/2003 Authors: Bozdayi AM; Uzunalimolu O; Trkyilmaz AR; Aslan N; Sezgin O; Sahin T; Bozdayi G; Cinar K; Pai SB; Pai R -
Synthesis and anti-HIV activity of enantiomerically pure D-FDOC
Volume: 8 Page(s): U22 - U22
06/01/2003 Authors: Mao S; Bouygues M; Welch C; Biba M; Chilenski J; Schinazi RF; Liotta DC -
Mechanism of anti-HIV activity of dioxolane nucleosides against lamivudine-resistant HIV-1 reverse transcriptase-molecular modelling approach
Volume: 8 Page(s): U46 - U47
06/01/2003 Authors: Chong YH; Schinazi RF; Chu CK -
Antiviral activity of the nucleoside Reverset following single oral doses in HIV-1-infected patients
Volume: 8 Page(s): U23 - U24
06/01/2003 Authors: Stuyver L; McBrayer TR; Murphy RL; Schurmann D; Kravec I; Beard A; Schinazi RF; De La Rosa A; Otto MJ -
Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.
Antimicrob Agents Chemother Volume: 47 Page(s): 1922 - 1928
06/01/2003 Authors: Chen H; Pai SB; Hurwitz SJ; Chu CK; Glazkova Y; McClure HM; Feitelson M; Schinazi RF -
K65R: a multi-nucleoside resistance mutation of low but increasing frequency
Volume: 8 Page(s): U131 - U132
06/01/2003 Authors: Parikh U; Koontz D; Hammond J; Bacheler L; Schinazi R; Meyer P; Scott W; Mellors J -
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge.
J Nat Prod Volume: 66 Page(s): 823 - 828
06/01/2003 Authors: Rao KV; Santarsiero BD; Mesecar AD; Schinazi RF; Tekwani BL; Hamann MT -
Using GENE-CODE technology to detect early emerging populations of drug-resistant human immunodeficiency virus Type I
Volume: 8 Page(s): U89 - U90
06/01/2003 Authors: Moser MJ; Sharma PL; Nurpeisov V; Schinazi RF; Prudent JR -
Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.
Antivir Chem Chemother Volume: 14 Page(s): 115 - 125
05/01/2003 Authors: Ray AS; Schinazi RF; Murakami E; Basavapathruni A; Shi J; Zorca SM; Chu CK; Anderson KS -
Synthesis of enantiomerically pure D-FDOC and its anti-HIV activity.
Volume: 225 Page(s): U231 - U231
03/01/2003 Authors: Mao SL; Liotta DC; Bouygues M; Welch CJ; Biba M; Schinazi RF -
N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.
Antivir Chem Chemother Volume: 14 Page(s): 81 - 90
03/01/2003 Authors: Shi J; Mathew JS; Tharnish PM; Rachakonda S; Pai SB; Adams M; Grier JP; Gallagher K; Zhang H; Wu J-T -
Synthesis and anti-HIV activities of L-beta-3 '-fluoro-2 ',3 '-dideoxy-2 ',3 '-didehydro-4 '-thio-nucleosides
Volume: 57 Page(s): A45 - A45
02/01/2003 Authors: Zhu W; Schinazi RF; Chu CK -
Structure-activity relationships of D- and L-3 '-fluoro-2 ',3 '-unsaturated nucleosides as anti-HIV agents.
Volume: 57 Page(s): A45 - A45
02/01/2003 Authors: Gumina G; Chong Y; Zhou W; Schinazi RF; Chu CK -
Anti-HIV activity and molecular mechanism of drug resistance of D- and L-2 '-F-4 '-S-d4N
Volume: 57 Page(s): A46 - A46
02/01/2003 Authors: Choo H; Chong Y; Schinazi RF; Chu CK -
Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
J Med Chem Volume: 46 Page(s): 389 - 398
01/30/2003 Authors: Choo H; Chong Y; Choi Y; Mathew J; Schinazi RF; Chu CK -
Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.
Antivir Chem Chemother Volume: 14 Page(s): 39 - 47
01/01/2003 Authors: Erickson-Viitanen S; Wu J-T; Shi G; Unger S; King RW; Fish B; Klabe R; Geleziunas R; Gallagher K; Otto MJ -
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.
Antimicrob Agents Chemother Volume: 47 Page(s): 244 - 254
01/01/2003 Authors: Stuyver LJ; Whitaker T; McBrayer TR; Hernandez-Santiago BI; Lostia S; Tharnish PM; Ramesh M; Chu CK; Jordan R; Shi J -
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).
Antivir Chem Chemother Volume: 14 Page(s): 49 - 59
01/01/2003 Authors: Geleziunas R; Gallagher K; Zhang H; Bacheler L; Garber S; Wu J-T; Shi G; Otto MJ; Schinazi RF; Erickson-Viitanen S -
2'-Fluoro-4'-thio-2',3'-unsaturated nucleosides: anti-HIV activity, resistance profile, and molecular modeling studies.
Nucleosides Nucleotides Nucleic Acids Volume: 22 Page(s): 611 - 615
01/01/2003 Authors: Chong Y; Choo H; Schinazi RF; Chu CK -
Synthesis and antiviral evaluation of 2',3'-dideoxy-2'-fluoro-3'- C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides.
Nucleosides Nucleotides Nucleic Acids Volume: 22 Page(s): 891 - 894
01/01/2003 Authors: Hassan AEA; Pai BS; Lostia S; Stuyver L; Otto MJ; Schinazi RF; Watanabe KA -
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.
Antimicrob Agents Chemother Volume: 46 Page(s): 3854 - 3860
12/01/2002 Authors: Stuyver LJ; Lostia S; Adams M; Mathew JS; Pai BS; Grier J; Tharnish PM; Choi Y; Chong Y; Choo H -
Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase.
Antiviral Res Volume: 56 Page(s): 189 - 205
12/01/2002 Authors: Ray AS; Murakami E; Peterson CN; Shi J; Schinazi RF; Anderson KS -
Synthesis of oxathiolane imidazole nucleosides.
Farmaco Volume: 57 Page(s): 993 - 997
12/01/2002 Authors: Kocabalkanli A; Schinazi RF -
Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors.
Antiviral Res Volume: 56 Page(s): 115 - 127
11/01/2002 Authors: Hurwitz SJ; Schinazi RF -
Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
J Med Chem Volume: 45 Page(s): 4888 - 4898
10/24/2002 Authors: Chong Y; Choo H; Choi Y; Mathew J; Schinazi RF; Chu CK -
Lamivudine (2,3-dideoxy-3-thiacytidine,3TC) delays the onset of hepatocellular carcinoma (HCC) and increases survival in the woodchuck model of chronic hepatitis B virus (HBV) infection
Volume: 36 Page(s): 627A - 627A
10/01/2002 Authors: Peek SF; Toshkov I; Erb H; Schinazi R; Korba B; Cote P; Gerin J; Tennant B -
Nucleosides for HBV and HCV: Back to the future.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 224 Page(s): U9 - U9
08/18/2002 Authors: Schinazi RF -
NAD-related IMP-dehydrogenase inhibitors with anti proliferative, cell differentiation, or apoptotic activity.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 224 Page(s): U264 - U265
08/18/2002 Authors: Pankiewicz KW; Patterson SE; Watanabe KA; Otto MJ; Black PL; Schinazi RF; Goldstein BM; Jayaram HN -
Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine.
Antiviral Res Volume: 55 Page(s): 141 - 150
07/01/2002 Authors: Tatti KM; Korba BE; Stang HL; Peek S; Gerin JL; Tennant BC; Schinazi RF -
Sexual transmission risk perceptions and behavioural correlates of HIV concentrations in semen.
AIDS Care Volume: 14 Page(s): 343 - 349
06/01/2002 Authors: Kalichman SC; Rompa D; Cage M; Austin J; Luke W; Barnett T; Tharnish P; Mowrey J; Schinazi RF -
Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.
J Virol Volume: 76 Page(s): 6083 - 6092
06/01/2002 Authors: Van Rompay KKA; Matthews TB; Higgins J; Canfield DR; Tarara RP; Wainberg MA; Schinazi RF; Pedersen NC; North TW -
DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants.
Antimicrob Agents Chemother Volume: 46 Page(s): 1394 - 1401
05/01/2002 Authors: Schinazi RF; Mellors J; Bazmi H; Diamond S; Garber S; Gallagher K; Geleziunas R; Klabe R; Pierce M; Rayner M -
Hepatitis B virus resistance to lamivudine and its clinical implications.
Antivir Chem Chemother Volume: 13 Page(s): 143 - 155
05/01/2002 Authors: Liu X; Schinazi RF -
Viral pharmacodynamic model for (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks.
Antivir Chem Chemother Volume: 13 Page(s): 165 - 176
05/01/2002 Authors: Hurwitz SJ; Tennant BC; Korba BE; Liberman I; Gerin JL; Schinazi RF -
Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.
Biochemistry Volume: 41 Page(s): 5150 - 5162
04/23/2002 Authors: Ray AS; Yang Z; Shi J; Hobbs A; Schinazi RF; Chu CK; Anderson KS -
Synthesis and anti-HIV activity of D-2 ',3 '-unsaturated-2 '-fluoro-4 '-thionucleosides.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 223 Page(s): B139 - B139
04/07/2002 Authors: Choo H; Chong Y; Lee S; Choi Y; Schinazi RF; Chu CK -
Detection of respiratory syncytial virus (RSV) by quantitative real time PCR (Q-RT-PCR)
PEDIATRIC RESEARCH Volume: 51 Page(s): 268A - 268A
04/01/2002 Authors: Guthrie CC; Mowery J; Stuyyer L; Schinazi RF -
Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents.
J Med Chem Volume: 45 Page(s): 1313 - 1320
03/14/2002 Authors: Lee K; Choi Y; Gumina G; Zhou W; Schinazi RF; Chu CK -
Synthesis and anti-HIV activity of D- and L-2 ',3 '-didehydro-2 ',3 '-dideoxy-2 '-fluoro-4 '-thiocytidines
ANTIVIRAL RESEARCH Volume: 53 Page(s): A36 - A36
03/01/2002 Authors: Chu CK; Choi YS; Choo H; Chong YH; Lee S; Zhu W; Schinazi RF -
Synthesis and anti-HIV activity of D- and L-3 '-dluoro-2 ',3 '-unsaturated cytidines.
ANTIVIRAL RESEARCH Volume: 53 Page(s): A41 - A41
03/01/2002 Authors: Chu CK; Gumina G; Zhou W; Schinazi RF -
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
Antivir Chem Chemother Volume: 13 Page(s): 115 - 128
03/01/2002 Authors: Chong Y; Borroto-Esoda K; Furman PA; Schinazi RF; Chu CK -
The synthesis and biological evaluation of novel bridging nucleoside analogues.
Bioorg Med Chem Volume: 10 Page(s): 273 - 281
02/01/2002 Authors: Marzabadi CH; Franck RW; Schinazi RF -
Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine.
Org Lett Volume: 4 Page(s): 305 - 307
01/24/2002 Authors: Choi Y; Choo H; Chong Y; Lee S; Olgen S; Schinazi RF; Chu CK -
Mechanism of anti-HIV activity of D4-nucleoside analogues against zidovudine- and lamivudine-resistant HIV-1 mutants: molecular modelling studies
ANTIVIRAL THERAPY Volume: 7 Page(s): S33 - S33
01/01/2002 Authors: Chong Y; Choo H; Schinazi RF; Chu CK -
Antiviral beta-L-nucleosides specific for hepatitis B virus infection
Page(s): 417 - 432
01/01/2002 Authors: Sommadossi JP -
Novel inhibitors of inosine monophosphate dehydrogenase (IMPDH)
Volume: 5 Page(s): 256 - 260
01/01/2002 Authors: Clark JL; Patterson SE; Mason JC; Otto MJ; Schinazi RF; Watanabe KA; Risal D; Goldstein BM; Pankiewicz KW -
Synthesis and potent anti-HIV activity of L-3'-fluoro-2',3'-unsaturated cytidine.
Org Lett Volume: 3 Page(s): 4177 - 4180
12/27/2001 Authors: Gumina G; Schinazi RF; Chu CK -
Human immunodeficiency virus in semen and plasma: investigation of sexual transmission risk behavioral correlates.
AIDS Res Hum Retroviruses Volume: 17 Page(s): 1695 - 1703
12/10/2001 Authors: Kalichman SC; Cage M; Barnett T; Tharnish P; Rompa D; Austin J; Luke W; O'Mowrey J; Schinazi RF -
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
J Med Chem Volume: 44 Page(s): 3985 - 3993
11/08/2001 Authors: Song GY; Paul V; Choo H; Morrey J; Sidwell RW; Schinazi RF; Chu CK -
Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy.
Cancer Chemother Pharmacol Volume: 48 Page(s): 389 - 397
11/01/2001 Authors: Al Safarjalani ON; Zhou XJ; Naguib FN; Shi J; Schinazi RF; el Kouni MH -
Synthesis and anti-HIV activity of L-2 ',3 '-didehydro-2 ',3 '-dideoxy-2 '-fluoro-4 '-thiocytidine.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 222 Page(s): U165 - U165
08/01/2001 Authors: Choi Y; Choo H; Chong YH; Lee S; Olgen S; Schinazi RF; Chu CK -
Molecular modeling, studies of drug resistance conferred by mutations in HIV-1 reverse transcriptase.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 222 Page(s): U668 - U668
08/01/2001 Authors: Chong YH; Shim JY; Schinazi RF; Chu CK -
Synthesis of L-3 '-fluoro unsaturated nucleosides as potential antiviral agents.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 222 Page(s): U165 - U165
08/01/2001 Authors: Gumina G; Zhou W; Schinazi RF; Chu CK -
Synthesis and antiviral activity of D4G prodrug.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 222 Page(s): U658 - U658
08/01/2001 Authors: Yang ZJ; Ray A; Anderson KS; Schinazi RF; Chu CK -
Synthesis of 3'-fluoro-2',3'-unsaturated D-nucleosides.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 222 Page(s): U123 - U123
08/01/2001 Authors: Zhou W; Gumina G; Schinazi RF; Chu CK -
Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy.
Cancer Chemother Pharmacol Volume: 48 Page(s): 145 - 150
08/01/2001 Authors: Al Safarjalani ON; Zhou XJ; Naguib FN; Goudgaon NM; Schinazi RF; el Kouni MH -
Cellular replication of human immunodeficiency virus type 1 occurs in vaginal secretions.
J Infect Dis Volume: 184 Page(s): 28 - 36
07/01/2001 Authors: Ellerbrock TV; Lennox JL; Clancy KA; Schinazi RF; Wright TC; Pratt-Palmore M; Evans-Strickfaden T; Schnell C; Pai R; Conley LJ -
Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region.
Hepatology Volume: 33 Page(s): 751 - 757
03/01/2001 Authors: Stuyver LJ; Locarnini SA; Lok A; Richman DD; Carman WF; Dienstag JL; Schinazi RF -
Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication.
Antivir Chem Chemother Volume: 12 Page(s): 99 - 108
03/01/2001 Authors: Placidi L; Faraj A; Loi AG; Pierra C; Egron D; Cretton-Scott E; Gosseli G; Prigaud C; Martin LT; Schinazi RF -
Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition.
J Am Chem Soc Volume: 123 Page(s): 886 - 897
02/07/2001 Authors: Judd DA; Nettles JH; Nevins N; Snyder JP; Liotta DC; Tang J; Ermolieff J; Schinazi RF; Hill CL -
The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance.
J Clin Invest Volume: 107 Page(s): 449 - 455
02/01/2001 Authors: Ono SK; Kato N; Shiratori Y; Kato J; Goto T; Schinazi RF; Carrilho FJ; Omata M -
Preclinical development of ss-D-5-o-carboranyl-2'-deoxyuridine (D-CDU) for the treatment of malignant brain tumors
Page(s): 1121 - 1124
01/01/2001 Authors: Schinazi RF; Hurwitz SJ; Liberman I; Juodawlkis A; Shi JX; Liotta DC; Coderre J; Olson J -
Antiviral beta-L-nucleosides specific for hepatitis B virus infection.
Antivir Chem Chemother Volume: 12 Suppl 1 Page(s): 119 - 129
01/01/2001 Authors: Standring DN; Bridges EG; Placidi L; Faraj A; Loi AG; Pierra C; Dukhan D; Gosselin G; Imbach JL; Hernandez B -
Early detection of mixed mutations selected by antiretroviral agents in HIV-infected primary human lymphocytes.
Antivir Chem Chemother Volume: 12 Suppl 1 Page(s): 61 - 65
01/01/2001 Authors: Schinazi RF; Schlueter-Wirtz S; Stuyver L -
Anti-HBV specific beta-L-2'-deoxynucleosides.
Nucleosides Nucleotides Nucleic Acids Volume: 20 Page(s): 597 - 607
01/01/2001 Authors: Bryant ML; Bridges EG; Placidi L; Faraj A; Loi AG; Pierra C; Dukhan D; Gosselin G; Imbach JL; Hernandez B -
Asymmetric synthesis of carbocyclic pyrimidine nucleosides via pi-allylpalladium complex.
Nucleosides Nucleotides Nucleic Acids Volume: 20 Page(s): 1367 - 1370
01/01/2001 Authors: Shi J; Schinazi RF -
Dynamic SIMS ion microscopy imaging of intracellular boron accumulation from carboranyl nucleosides in glioma cells.
Anticancer Res Volume: 21 Page(s): 2369 - 2375
01/01/2001 Authors: Gay I; Lorey DR; Schinazi RF; Morrison GH; Chandra S -
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
Antimicrob Agents Chemother Volume: 45 Page(s): 158 - 165
01/01/2001 Authors: Furman PA; Jeffrey J; Kiefer LL; Feng JY; Anderson KS; Borroto-Esoda K; Hill E; Copeland WC; Chu CK; Sommadossi JP -
Antiviral L-nucleosides specific for hepatitis B virus infection.
Antimicrob Agents Chemother Volume: 45 Page(s): 229 - 235
01/01/2001 Authors: Bryant ML; Bridges EG; Placidi L; Faraj A; Loi AG; Pierra C; Dukhan D; Gosselin G; Imbach JL; Hernandez B -
Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates.
Antimicrob Agents Chemother Volume: 44 Page(s): 3465 - 3472
12/01/2000 Authors: Meyer PR; Matsuura SE; Schinazi RF; So AG; Scott WA -
Synthesis and antiviral activity of oxaselenolane nucleosides.
J Med Chem Volume: 43 Page(s): 3906 - 3912
10/19/2000 Authors: Chu CK; Ma L; Olgen S; Pierra C; Du J; Gumina G; Gullen E; Cheng YC; Schinazi RF -
Influence of B domain mutation (L528M) of the hepatitis B virus polymerase on replication ability and resistance to nucleoside analogues.
HEPATOLOGY Volume: 32 Page(s): 393A - 393A
10/01/2000 Authors: Ona-Nita SK; Kato N; Shiratori Y; Yoshida H; Kato J; Goto T; Schinazi RF; Carrilho FJ; Omata M -
5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase.
Biochem Pharmacol Volume: 60 Page(s): 851 - 856
09/15/2000 Authors: el Kouni MH; Goudgaon NM; Rafeeq M; Al Safarjalani ON; Schinazi RF; Naguib FN -
Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.
Biochem Pharmacol Volume: 60 Page(s): 687 - 692
09/01/2000 Authors: Ashour OM; Naguib FN; Goudgaon NM; Schinazi RF; el Kouni MH -
Synthesis of 2',3'-dideoxy-3'-fluoro-L-ribonucleosides as potential antiviral agents from D-sorbitol.
Carbohydr Res Volume: 328 Page(s): 49 - 59
08/18/2000 Authors: Chun BK; Schinazi RF; Cheng YC; Chu CK -
Synthesis of novel 3'-C-methyl-apionucleosides: an asymmetric construction of a quaternary carbon by Claisen rearrangement.
Carbohydr Res Volume: 328 Page(s): 37 - 48
08/18/2000 Authors: Hong JH; Gao MY; Choi Y; Cheng YC; Schinazi RF; Chu CK -
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine.
Antimicrob Agents Chemother Volume: 44 Page(s): 1783 - 1788
07/01/2000 Authors: Bazmi HZ; Hammond JL; Cavalcanti SC; Chu CK; Schinazi RF; Mellors JW -
Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks.
Antimicrob Agents Chemother Volume: 44 Page(s): 1757 - 1760
06/01/2000 Authors: Korba BE; Schinazi RF; Cote P; Tennant BC; Gerin JL -
Enhanced antiviral benefit of combination therapy with lamivudine and alpha interferon against WHV replication in chronic carrier woodchucks.
Antivir Ther Volume: 5 Page(s): 95 - 104
06/01/2000 Authors: Korba BE; Cote P; Hornbuckle W; Schinazi R; Gangemi JD; Tennant BC; Gerin JL -
L-enantiomers of 2 '- and 3 '-azido-2 ',3 '-dideoxyd-5-fluorocytidine: Stereospecific synthesis and antiviral activity
ANTIVIRAL RESEARCH Volume: 46 Page(s): A35 - A35
04/01/2000 Authors: Gosselin G; Griffon JF; Hollecker L; Imbach JL; Bryant M; Schinazi RF; Sommadossi JP -
Mutations in the woodchuck hepatitis B virus (WHV) genome that confer resistance to lamivudine and penciclovir.
ANTIVIRAL RESEARCH Volume: 46 Page(s): A57 - A57
04/01/2000 Authors: Korba B; Tatti K; Wells F; Gerin J; Schinazi R -
beta-L-thymidine and beta-L-2 '-deoxycytidine are potent, selective and specific anti-hepatitis B virus agents.
ANTIVIRAL RESEARCH Volume: 46 Page(s): A62 - A62
04/01/2000 Authors: Faraj A; Loi AG; Cui L; Xie MY; Bryant M; Bridges EG; Joudawis A; Pierra C; Dukhan D; Gosselin G -
Importance of stereochemistry in the design and selection of resistance mutations to D4-nucleosides.
ANTIVIRAL RESEARCH Volume: 46 Page(s): A36 - A36
04/01/2000 Authors: Schinazi RF; Pai B; Schlueter-Wirtz S; Martin SA; Tharnish PM; Liotta DC; Chu CK; Hammond JL; Mellors JW -
Mololipids, a new series of anti-HIV bromotyramine-derived compounds from a sponge of the order verongida.
J Nat Prod Volume: 63 Page(s): 501 - 503
04/01/2000 Authors: Ross SA; Weete JD; Schinazi RF; Wirtz SS; Tharnish P; Scheuer PJ; Hamann MT -
Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.
Antimicrob Agents Chemother Volume: 44 Page(s): 853 - 858
04/01/2000 Authors: Placidi L; Cretton-Scott E; Gosselin G; Pierra C; Schinazi RF; Imbach JL; el Kouni MH; Sommadossi JP -
Antiviral activity of beta-L-thymidine and beta-L-2 '-deoxycytidine in the woodchuck model of chronic hepatitis B infection.
ANTIVIRAL RESEARCH Volume: 46 Page(s): A62 - A62
04/01/2000 Authors: Bridges EG; Juodawikis A; Faraj A; Tennant B; Korba B; Schinazi RF; Barnett T; Gosselin G; Imbach JL; Pierra C -
Anti-hepatitis B specific beta-L-2 '-deoxynucleosides.
ANTIVIRAL RESEARCH Volume: 46 Page(s): A55 - A55
04/01/2000 Authors: Bryant ML; Gosselin G; Schinazi RF; Imbach JL; Sommadossi JP -
Novel peptides inhibit HIV-1 replication in SCID mice: Relevance of the SCID mouse model for human trials
ANTIVIRAL RESEARCH Volume: 46 Page(s): A70 - A70
04/01/2000 Authors: Black PL; Lambert DM; Schinazi RF; Ussery MA -
Synthesis of 2',3'-dideoxy-2'-beta-fluoro-3'-(N-substituted-amino)-(D)-arabinofuranosyl nucleosides.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 219 Page(s): U128 - U128
03/26/2000 Authors: Pan SF; Schinazi RF; Zhao K -
Cellular pharmacology of the D- and L-enantiomers of beta-5-o-carboranyl-2'-deoxyuridine.
Nucleosides Nucleotides Nucleic Acids Volume: 19 Page(s): 691 - 702
03/01/2000 Authors: Hurwitz SJ; Ma L; Eleuteri A; Wright J; Moravek J; Schinazi RF -
Treatment of isografted 9L rat brain tumors with beta-5-o-carboranyl-2'-deoxyuridine neutron capture therapy.
Clin Cancer Res Volume: 6 Page(s): 725 - 730
02/01/2000 Authors: Schinazi RF; Hurwitz SJ; Liberman I; Juodawlkis AS; Tharnish P; Shi J; Liotta DC; Coderre JA; Olson J -
Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.
J Biol Chem Volume: 275 Page(s): 359 - 366
01/07/2000 Authors: Klarmann GJ; Smith RA; Schinazi RF; North TW; Preston BD -
Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.
J Virol Volume: 74 Page(s): 684 - 692
01/01/2000 Authors: Gustafson EA; Schinazi RF; Fingeroth JD -
A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness.
J Gen Virol Volume: 81 Page(s): 67 - 74
01/01/2000 Authors: Stuyver L; De Gendt S; Van Geyt C; Zoulim F; Fried M; Schinazi RF; Rossau R -
Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks.
Antiviral Res Volume: 45 Page(s): 19 - 32
01/01/2000 Authors: Korba BE; Cote P; Hornbuckle W; Schinazi R; Gerin JL; Tennant BC -
Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: relevance to chemotherapy.
Cancer Chemother Pharmacol Volume: 45 Page(s): 351 - 361
01/01/2000 Authors: Ashour OM; Al Safarjalani ON; Naguib FN; Goudgaon NM; Schinazi RF; el Kouni MH -
In vitro and in vivo metabolism and pharmacokinetics of bis [(t-butyl)-S-acyl-2-thioethyl]-beta-L-2',3'-dideoxy-5-fluorocytidine monophosphate.
Nucleosides Nucleotides Nucleic Acids Volume: 19 Page(s): 481 - 499
01/01/2000 Authors: Martin LT; Cretton-Scott E; Placidi L; Faraj A; Loi AG; Schinazi RF; McClure HM; Gosselin G; Imbach JL; Sommadossi JP -
Synthesis and antiviral activities of enantiomeric 1-[2-(hydroxymethyl) cyclopropyl] methyl nucleosides.
Nucleosides Nucleotides Nucleic Acids Volume: 19 Page(s): 253 - 268
01/01/2000 Authors: Pierra C; Olgen S; Cavalcanti SC; Cheng YC; Schinazi RF; Chu CK -
Laboratory safety considerations.
Methods Mol Med Volume: 24 Page(s): 13 - 25
01/01/2000 Authors: Feorino PM; Williamson JD; Schinazi RF -
Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2',3',5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy.
Cancer Chemother Pharmacol Volume: 46 Page(s): 235 - 240
01/01/2000 Authors: Ashour OM; Naguib FN; Goudgaon NM; Schinazi RF; el Kouni MH -
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.
AIDS Res Hum Retroviruses Volume: 15 Page(s): 1625 - 1630
12/10/1999 Authors: Chen H; Schinazi RF; Rajagopalan P; Gao Z; Chu CK; McClure HM; Boudinot FD -
Enantioselective synthesis and biological evaluation of 5-o-carboranyl pyrimidine nucleosides.
Bioorg Med Chem Volume: 7 Page(s): 2759 - 2766
12/01/1999 Authors: Mourier NS; Eleuteri A; Hurwitz SJ; Tharnish PM; Schinazi RF -
Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.
Nucleosides Nucleotides Volume: 18 Page(s): 2233 - 2252
10/01/1999 Authors: Cavalcanti SC; Xiang Y; Newton MG; Schinazi RF; Cheng YC; Chu CK -
L-FMAU treatment of woodchucks chronically infected with WHV
HEPATOLOGY Volume: 30 Page(s): 345A - 345A
10/01/1999 Authors: Zhu Y; Cullen J; Schinazi R; Furman PA -
Screening of new antivirals for lamivudine-resistant hepatitis B virus.
HEPATOLOGY Volume: 30 Page(s): 346A - 346A
10/01/1999 Authors: Ono-Nita SK; Kato N; Shiratori Y; Yoshida H; Kato J; Schinazi RF; Omata M -
Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP.
FASEB J Volume: 13 Page(s): 1511 - 1517
09/01/1999 Authors: Feng JY; Shi J; Schinazi RF; Anderson KS -
Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.
J Med Chem Volume: 42 Page(s): 3390 - 3399
08/26/1999 Authors: Wang P; Gullen B; Newton MG; Cheng YC; Schinazi RF; Chu CK -
Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV agents.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 218 Page(s): U912 - U912
08/22/1999 Authors: Lee K; Choi Y; Schinazi RF; Chu CK -
A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine.
Antimicrob Agents Chemother Volume: 43 Page(s): 2077 - 2080
08/01/1999 Authors: Smith RA; Klarmann GJ; Stray KM; von Schwedler UK; Schinazi RF; Preston BD; North TW -
Cell-based and animal models for hepatitis B and C viruses.
Antivir Chem Chemother Volume: 10 Page(s): 99 - 114
05/01/1999 Authors: Schinazi RF; Ilan E; Black PL; Yao X; Dagan S -
Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.
J Med Chem Volume: 42 Page(s): 1320 - 1328
04/08/1999 Authors: Lee K; Choi Y; Gullen E; Schlueter-Wirtz S; Schinazi RF; Cheng YC; Chu CK -
Correlation of human immunodeficiency virus type 1 RNA levels in blood and the female genital tract.
Volume: 179 Page(s): 871 - 882
04/01/1999 Authors: Hart CE; Lennox JL; Pratt-Palmore M; Wright TC; Schinazi RF; Evans-Strickfaden T; Bush TJ; Schnell C; Conley LJ; Clancy KA -
Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 43 Page(s): 920 - 924
04/01/1999 Authors: Martin LT; Cretton-Scott E; Schinazi RF; Zhou XJ; McClure HM; Mathe C; Gosselin G; Imbach JL; Sommadossi JP -
Synthesis and antiviral activities of oxaselenolane nucleosides
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 217 Page(s): U1209 - U1210
03/21/1999 Authors: Olgen S; Pierra C; Du JF; Surzykov S; Gullen E; Cheng YC; Schinazi RF; Chu CK -
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
J Med Chem Volume: 42 Page(s): 859 - 867
03/11/1999 Authors: Shi J; McAtee JJ; Schlueter Wirtz S; Tharnish P; Juodawlkis A; Liotta DC; Schinazi RF -
A rapid non-culture-based assay for clinical monitoring of phenotypic resistance of human immunodeficiency virus type 1 to lamivudine (3TC).
Antimicrob Agents Chemother Volume: 43 Page(s): 264 - 270
02/01/1999 Authors: Garca Lerma J; Schinazi RF; Juodawlkis AS; Soriano V; Lin Y; Tatti K; Rimland D; Folks TM; Heneine W -
Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 43 Page(s): 381 - 384
02/01/1999 Authors: Ma L; Hurwitz SJ; Shi J; Mcatee JJ; Liotta DC; McClure HM; Schinazi RF -
Stavudine resistance: an update on susceptibility following prolonged therapy.
Antivir Ther Volume: 4 Page(s): 21 - 28
01/01/1999 Authors: Lin PF; Gonzlez CJ; Griffith B; Friedland G; Calvez V; Ferchal F; Schinazi RF; Shepp DH; Ashraf AB; Wainberg MA -
New classes of fluorinated L-nucleosides; synthesis and antiviral activity.
Nucleosides Nucleotides Volume: 18 Page(s): 537 - 540
01/01/1999 Authors: Lee K; Choi Y; Hong JH; Schinazi RF; Chu CK -
Intracellular metabolism of beta-L-ddAMP-bis(tbutylSATE), a potent inhibitor of hepatitis B virus replication.
Nucleosides Nucleotides Volume: 18 Page(s): 987 - 988
01/01/1999 Authors: Faraj A; Placidi L; Perigaud C; Cretton-Scott E; Gosselin G; Martin LT; Pierra C; Schinazi RF; Imbach JL; Sommadossi JP -
Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.
Nucleosides Nucleotides Volume: 18 Page(s): 1005 - 1006
01/01/1999 Authors: Loi AG; Faraj A; Pierra C; Gosselin G; Imbach JL; Locarnini SA; Groman EV; Schinazi RF; Sommadossi JP -
Pharmacodynamics of (-)-beta-2 ',3 '-dideoxy-3 '-thiacytidine in chronically virus-infected woodchucks compared to its pharmacodynamics in humans (vol 42, pg 2804, 1998)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Volume: 42 Page(s): 3337 - 3337
12/01/1998 Authors: Hurwitz SJ; Tennant BC; Korba BE; Gerin JL; Schinazi RF -
Pharmacodynamics of (-)-beta-2',3'-dideoxy-3'-thiacytidine in chronically virus-infected woodchucks compared to its pharmacodynamics in humans.
Antimicrob Agents Chemother Volume: 42 Page(s): 2804 - 2809
11/01/1998 Authors: Hurwitz SJ; Tennant BC; Korba BE; Gerin JL; Schinazi RF -
Dynamics of emergence and disappearance of antiviral drug-associated mutations in hepatitis B virus.
HEPATOLOGY Volume: 28 Page(s): 489A - 489A
10/01/1998 Authors: Schinazi RF; Van Geyt C; Stang H; Peters J; Tatti K; Stuyver L; Fried MW -
Chemical approaches for controlling Hepatitis infections.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 216 Page(s): U313 - U313
08/23/1998 Authors: Liotta DC; Schinazi RF -
Synthesis and anti-HIV activity of L-2 '-fluoro-2 ',3 '-unsaturated pyrimidine and purine nucleosides
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 216 Page(s): U264 - U264
08/23/1998 Authors: Lee K; Choi YS; Hong JH; Schinazi RF; Chu CK -
Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine.
Bioorg Med Chem Lett Volume: 8 Page(s): 1585 - 1588
07/07/1998 Authors: Wang P; Schinazi RF; Chu CK -
Chiral liquid chromatographic separation of 3 '-heteronucleosides on amylose chiral stationary phase and their anti-HIV activity in human lymphocytes.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 215 Page(s): U123 - U123
04/02/1998 Authors: Ma L; Shi J; Chu CK; Schinazi RF -
Synthesis and biological properties of the four optical isomers of 5-o-carboranyl-2',3'-didehydro-2',3'-dideoxyuridine.
Nucleosides Nucleotides Volume: 17 Page(s): 711 - 727
04/01/1998 Authors: Graciet JC; Shi J; Schinazi RF -
A novel point mutation at position 156 of reverse transcriptase from feline immunodeficiency virus confers resistance to the combination of (-)-beta-2',3'-dideoxy-3'-thiacytidine and 3'-azido-3'-deoxythymidine.
J Virol Volume: 72 Page(s): 2335 - 2340
03/01/1998 Authors: Smith RA; Remington KM; Preston BD; Schinazi RF; North TW -
Polyoxometalates in Medicine.
Chem Rev Volume: 98 Page(s): 327 - 358
02/05/1998 Authors: Rhule JT; Hill CL; Judd DA; Schinazi RF -
In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum.
J Antimicrob Chemother Volume: 41 Page(s): 293 - 296
02/01/1998 Authors: You X; Schinazi RF; Arrowood MJ; Lejkowski M; Juodawlkis AS; Mead JR -
Synthesis and anti-HIV activity of bis(methano fullerene)polyoxometalates
Volume: 98 Page(s): 1222 - 1226
01/01/1998 Authors: Zheng ZM; Juodawlkis AS; Wirtz SS; Schinazi RF; Zeng HD; Bellavia C; Wudl F; Hill CL -
Advances in therapies for viral hepatitis
ANTIVIRAL THERAPY Volume: 3 Page(s): VII - IX
01/01/1998 Authors: Schinazi RF; Sommadossi JP -
Boron containing oligonucleotides.
Nucleosides Nucleotides Volume: 17 Page(s): 635 - 647
01/01/1998 Authors: Schinazi RF; Lesnikowski ZJ -
Antiviral drug resistance: from the laboratory to the patient.
Antivir Ther Volume: 3 Page(s): 237
01/01/1998 Authors: Pillay D; Schinazi RF -
Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes.
Antimicrob Agents Chemother Volume: 41 Page(s): 2502 - 2510
11/01/1997 Authors: Pan-Zhou XR; Cretton-Scott E; Zhou XJ; Xie MY; Rahmani R; Schinazi RF; Duchin K; Sommadossi JP -
Biologic properties of human herpesvirus 7 strain SB.
Virus Res Volume: 52 Page(s): 25 - 41
11/01/1997 Authors: Black JB; Burns DA; Goldsmith CS; Feorino PM; Kite-Powell K; Schinazi RF; Krug PW; Pellett PE -
Structure-activity relationships of 2'-deoxy-2',2'-difluoro-L-erythro-pentofuranosyl nucleosides.
J Med Chem Volume: 40 Page(s): 3635 - 3644
10/24/1997 Authors: Kotra LP; Xiang Y; Newton MG; Schinazi RF; Cheng YC; Chu CK -
An Efficient Route to beta-D-Isoxazolidinyl Nucleosides via Diastereoselective Michael Addition of Hydroxylamine to Unsaturated Esters.
J Org Chem Volume: 62 Page(s): 7430 - 7434
10/17/1997 Authors: Xiang Y; Gi H-J; Niu D; Schinazi RF; Zhao K -
Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs.
J Med Chem Volume: 40 Page(s): 3323 - 3331
10/10/1997 Authors: McIntee EJ; Remmel RP; Schinazi RF; Abraham TW; Wagner CR -
3'-thiacytidine (3TC) delays development of hepatocellular carcinoma (HCC) in woodchucks with experimentally induced chronic woodchuck hepatitis virus (WHV) infection. Preliminary results of a lifetime study.
HEPATOLOGY Volume: 26 Page(s): 957 - 957
10/01/1997 Authors: Peek SF; Toshkov IA; Erb HN; Schinazi RF; Korba BE; Cote PJ; Gerin JL; Tennant BC -
Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides.
J Med Chem Volume: 40 Page(s): 2991 - 2993
09/12/1997 Authors: Du J; Surzhykov S; Lin JS; Newton MG; Cheng YC; Schinazi RF; Chu CK -
Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 214 Page(s): 83 - CARB
09/07/1997 Authors: Du JF; Surzhykov S; Lin JS; Newton MG; Cheng YC; Schinazi RF; Chu CK -
Synthesis and biological activities of optical isomers of 5-O-carboranyl-2',3'-didehydro-2',3'-dideoxyuridine (D4CU).
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 214 Page(s): 79 - CARB
09/07/1997 Authors: Shi J; Graciet JCG; Schinazi RF -
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
J Nat Prod Volume: 60 Page(s): 884 - 888
09/01/1997 Authors: Lin YM; Anderson H; Flavin MT; Pai YH; Mata-Greenwood E; Pengsuparp T; Pezzuto JM; Schinazi RF; Hughes SH; Chen FC -
Biotransformation and pharmacokinetics of prodrug 9-(beta-D-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(beta-D-1,3-dioxolan-4-yl)guanine in mice.
Antiviral Res Volume: 35 Page(s): 187 - 193
08/01/1997 Authors: Manouilov KK; Manouilova LS; Boudinot FD; Schinazi RF; Chu CK -
Lymphatic targeting of anti-HIV nucleosides: distribution of 2',3'-dideoxyinosine after intravenous and oral administration of dipalmitoylphosphatidyl prodrug in mice.
Antiviral Res Volume: 34 Page(s): 91 - 99
05/01/1997 Authors: Manouilov KK; Xu ZS; Boudinot FD; Schinazi RF; Chu CK -
Chemical approaches for treating HIV and hepatitis B infections.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 213 Page(s): 54 - BIOT
04/13/1997 Authors: Liotta DC; Schinazi RF -
High-performance liquid chromatographic determination of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane, and their metabolite (-)-beta-D-dioxolane guanine in monkey serum, urine and cerebrospinal fluid.
J Chromatogr B Biomed Sci Appl Volume: 691 Page(s): 425 - 432
04/11/1997 Authors: Chen H; Manouilov KK; Chu CK; Schinazi RF; McClure HM; Boudinot FD -
Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes.
Antiviral Res Volume: 34 Page(s): 27 - 37
03/01/1997 Authors: Barnard DL; Hill CL; Gage T; Matheson JE; Huffman JH; Sidwell RW; Otto MI; Schinazi RF -
A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides.
J Virol Volume: 71 Page(s): 2357 - 2362
03/01/1997 Authors: Smith RA; Remington KM; Lloyd RM; Schinazi RF; North TW -
Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene.
Antimicrob Agents Chemother Volume: 41 Page(s): 284 - 291
02/01/1997 Authors: Stuyver L; Wyseur A; Rombout A; Louwagie J; Scarcez T; Verhofstede C; Rimland D; Schinazi RF; Rossau R -
Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs.
J Org Chem Volume: 62 Page(s): 88 - 92
01/10/1997 Authors: Gi H-J; Xiang Y; Schinazi RF; Zhao K -
Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells.
Biochem Pharmacol Volume: 53 Page(s): 75 - 87
01/10/1997 Authors: Martin LT; Faraj A; Schinazi RF; Gosselin G; Mathe C; Imbach JL; Sommadossi JP -
Anti-human immunodeficiency virus activity of polyhydroxy fullerenes in vitro
Volume: 97 Page(s): 357 - 360
01/01/1997 Authors: Schinazi RF; Chiang LY; Wilson LJ; Cagle DW; Hill CL -
Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.
J Med Chem Volume: 39 Page(s): 5202 - 5207
12/20/1996 Authors: Kotra LP; Manouilov KK; Cretton-Scott E; Sommadossi JP; Boudinot FD; Schinazi RF; Chu CK -
Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.
Biochem Pharmacol Volume: 52 Page(s): 1577 - 1584
11/22/1996 Authors: Cui L; Schinazi RF; Gosselin G; Imbach JL; Chu CK; Rando RF; Revankar GR; Sommadossi JP -
In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.
J Med Chem Volume: 39 Page(s): 4676 - 4681
11/08/1996 Authors: Koudriakova T; Manouilov KK; Shanmuganathan K; Kotra LP; Boudinot FD; Cretton-Scott E; Sommadossi JP; Schinazi RF; Chu CK -
Pharmacokinetics of a water-soluble fullerene in rats.
Antimicrob Agents Chemother Volume: 40 Page(s): 2262 - 2265
10/01/1996 Authors: Rajagopalan P; Wudl F; Schinazi RF; Boudinot FD -
Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 40 Page(s): 2332 - 2336
10/01/1996 Authors: Chen H; Boudinot FD; Chu CK; Mcclure HM; Schinazi RF -
Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii.
Biochem Pharmacol Volume: 51 Page(s): 1687 - 1700
06/28/1996 Authors: el Kouni MH; Naguib FN; Panzica RP; Otter BA; Chu SH; Gosselin G; Chu CK; Schinazi RF; Shealy YF; Goudgaon N -
N-O Diheterocyclic nucleosides: Synthesis of 2'-N-methyl-3'-hydroxymethyl-1',2'-isoxazolidinylthymidine (vol 36, pg 7193, 1995)
TETRAHEDRON LETTERS Volume: 37 Page(s): 3779 - 3779
05/27/1996 Authors: Xiang Y; Chen J; Schinazi RF; Zhao K -
Carboranyl oligonucleotides. 3. Biochemical properties of oligonucleotides containing 5-(o-carboranyl-1-yl)-2'-deoxyuridine.
Biochemistry Volume: 35 Page(s): 5741 - 5746
05/07/1996 Authors: Lesnikowski ZJ; Fulcrand G; Lloyd RM; Juodawlkis A; Schinazi RF -
Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.
Antimicrob Agents Chemother Volume: 40 Page(s): 1270 - 1273
05/01/1996 Authors: Cherrington JM; Fuller MD; Mulato AS; Allen SJ; Kunder SC; Ussery MA; Lesnikowski Z; Schinazi RF; Sommadossi JP; Chen MS -
Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.
Mol Pharmacol Volume: 49 Page(s): 621 - 628
04/01/1996 Authors: Mazumder A; Neamati N; Sommadossi JP; Gosselin G; Schinazi RF; Imbach JL; Pommier Y -
A chemiluminescence immunoassay for evaluation of Cryptosporidium parvum growth in vitro.
FEMS Microbiol Lett Volume: 136 Page(s): 251 - 256
03/01/1996 Authors: You X; Arrowood MJ; Lejkowski M; Xie L; Schinazi RF; Mead JR -
Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.
Antiviral Res Volume: 29 Page(s): 261 - 267
03/01/1996 Authors: Faraj A; Schinazi RF; Xie MY; Gosselin G; Perigaud C; Imbach JL; Sommadossi JP -
Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.
Antimicrob Agents Chemother Volume: 40 Page(s): 642 - 645
03/01/1996 Authors: Rajagopalan P; Boudinot FD; Chu CK; Tennant BC; Baldwin BH; Schinazi RF -
Cloning and expression of sporozoite and oocyst Cryptosporidium parvum recombinant proteins.
Volume: 43 Page(s): 83S
01/01/1996 Authors: Bonafonte MT; Lloyd RM; Garmon KD; You X; Arrowood MJ; Schinazi RF; Mead JR -
Subcellular localization of a boronated nucleoside using ion microscopy
Page(s): 209 - 213
01/01/1996 Authors: Gay I; Schinazi RF; Liotta DC; Morrison GH -
In vitro expression of mRNA coding for a Cryptosporidium parvum oocyst wall protein.
Volume: 43 Page(s): 84S - 85S
01/01/1996 Authors: Mead JR; Bonafonte MT; Arrowood MJ; Schinazi RF -
Synthesis of dodeca(thymidine phosphate) containing (o-carboran-1-yl)methylphosphonate internucleotide linkage
Volume: 111 Page(s): 714 - 714
01/01/1996 Authors: Lesnikowski ZJ; Schinazi RF -
Synthesis and anti-HIV-1 reverse transcriptase activity of triphosphates of penciclovir and beta-D-dioxolane-guanine
Volume: 111 Page(s): 715 - 715
01/01/1996 Authors: Lesnikowski ZJ; Juodawlkis AS; Lloyd RM; Chu CK; Schinazi RF -
In vitro evaluation of anticryptosporidial agents using MDCK cell culture and chemiluminescence immunoassay.
Volume: 43 Page(s): 87S
01/01/1996 Authors: You X; Arrowood MJ; Lejkowski M; Xie L; Schinazi RF; Mead JR -
Hydrocephalus induction in mice infected with herpes simplex virus type 2 after antiviral treatment.
Antiviral Res Volume: 28 Page(s): 291 - 302
12/01/1995 Authors: Schinazi RF; Yao X -
High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection.
J Chromatogr B Biomed Appl Volume: 672 Page(s): 119 - 124
10/06/1995 Authors: Rajagopalan P; Gao Z; Chu CK; Schinazi RF; McClure HM; Boudinot FD -
Phosphatidyl-2',3'-dideoxy-3'-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells.
Antiviral Res Volume: 28 Page(s): 113 - 120
10/01/1995 Authors: Xie H; Voronkov M; Liotta DC; Korba BA; Schinazi RF; Richman DD; Hostetler KY -
Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thymine derivatives.
Bioorg Med Chem Volume: 3 Page(s): 1223 - 1229
09/01/1995 Authors: Wengel J; Schinazi RF; Caruthers MH -
L-NUCLEOSIDES - A NEW PARADIGM FOR DEVELOPING LOW TOXICITY ANTIVIRAL AGENTS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 210 Page(s): 26 - ORGN
08/20/1995 Authors: LIOTTA DC; SCHINAZI RF -
Pharmacokinetics and toxicity of the human immunodeficiency virus inhibitor 1-ethoxymethyl-6-phenylselenenyl-5-ethyluracil in rodents.
Antiviral Res Volume: 27 Page(s): 39 - 47
05/01/1995 Authors: Ni L; Schinazi RF; Boudinot FD -
Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates.
Antimicrob Agents Chemother Volume: 39 Page(s): 1087 - 1092
05/01/1995 Authors: Mellors JW; Bazmi HZ; Schinazi RF; Roy BM; Hsiou Y; Arnold E; Weir J; Mayers DL -
Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis.
Antimicrob Agents Chemother Volume: 39 Page(s): 854 - 858
04/01/1995 Authors: Mead JR; You X; Pharr JE; Belenkaya Y; Arrowood MJ; Fallon MT; Schinazi RF -
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
J Clin Invest Volume: 95 Page(s): 555 - 563
02/01/1995 Authors: Cui L; Yoon S; Schinazi RF; Sommadossi JP -
2'-DEOXY-BETA-L-PENTOFURANOSYL AND/OR 3'-DEOXY-BETA-L-PENTOFURANOSYL NUCLEOSIDE DERIVATIVES - STEREOSPECIFIC SYNTHESIS AND ANTIVIRAL ACTIVITIES
NUCLEOSIDES & NUCLEOTIDES Volume: 14 Page(s): 611 - 617
01/01/1995 Authors: GOSSELIN G; MATHE C; BERGOGNE MC; AUBERTIN AM; KIRN A; SOMMADOSSI JP; SCHINAZI R; IMBACH JL -
Development of HIV-1 and SIV resistant to beta-L-2',3'-dideoxycytidine analogues
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY Volume: 10 Page(s): 10 - 10
01/01/1995 Authors: Schinazi RF; Lloyd RM; McMillan A; Gosselin G; Imbach JL; Sommadossi JP -
Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY Volume: 10 Page(s): 92 - 92
01/01/1995 Authors: Mellors JW; Larder BA; Schinazi R; Deverson C -
Synthesis of dicationic diarylpyridines as nucleic-acid binding agents.
Eur J Med Chem Volume: 30 Page(s): 99 - 106
01/01/1995 Authors: Kumar A; Rhodes R; Spychala J; Wilson W; Boykin D; Tidwell R; Dykstra C; Hall J; Jones S; Schinazi R -
Pharmacokinetics of 5-carboranyl-2'-deoxyuridine in rats.
J Pharm Sci Volume: 83 Page(s): 1697 - 1699
12/01/1994 Authors: Jarugula VR; Schinazi RF; Fulcrand G; el Kattan Y; Liotta DC; Boudinot FD -
BASE-CATALYZED TRANSESTERIFICATION METHOD FOR INTERNUCLEOTIDE LINKAGE FORMATION
NEW JOURNAL OF CHEMISTRY Volume: 18 Page(s): 1197 - 1204
11/01/1994 Authors: LESNIKOWSKI ZJ; ZABAWSKA D; JAWORSKAMASLANKA MM; SCHINAZI RF; STEC WJ -
Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.
Antimicrob Agents Chemother Volume: 38 Page(s): 2300 - 2305
10/01/1994 Authors: Faraj A; Agrofoglio LA; Wakefield JK; McPherson S; Morrow CD; Gosselin G; Mathe C; Imbach JL; Schinazi RF; Sommadossi JP -
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines.
Antimicrob Agents Chemother Volume: 38 Page(s): 2409 - 2414
10/01/1994 Authors: Nguyen MH; Schinazi RF; Shi C; Goudgaon NM; McKenna PM; Mellors JW -
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.
Antimicrob Agents Chemother Volume: 38 Page(s): 2172 - 2174
09/01/1994 Authors: Schinazi RF; Gosselin G; Faraj A; Korba BE; Liotta DC; Chu CK; Math C; Imbach JL; Sommadossi JP -
Multiple drug effect analysis with confidence interval.
Antiviral Res Volume: 25 Page(s): 1 - 11
09/01/1994 Authors: Belen'kii MS; Schinazi RF -
Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil.
J Med Chem Volume: 37 Page(s): 2583 - 2588
08/05/1994 Authors: Fulcrand-el Kattan G; Goudgaon NM; Ilksoy N; Huang JT; Watanabe KA; Sommadossi JP; Schinazi RF -
Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro.
Antimicrob Agents Chemother Volume: 38 Page(s): 1292 - 1297
06/01/1994 Authors: Gosselin G; Schinazi RF; Sommadossi JP; Math C; Bergogne MC; Aubertin AM; Kirn A; Imbach JL -
Infection dynamics and clinical features of cryptosporidiosis in SCID mice.
Infect Immun Volume: 62 Page(s): 1691 - 1695
05/01/1994 Authors: Mead JR; Ilksoy N; You X; Belenkaya Y; Arrowood MJ; Fallon MT; Schinazi RF -
Cellular pharmacology and biological activity of 5-carboranyl-2'-deoxyuridine.
Int J Radiat Oncol Biol Phys Volume: 28 Page(s): 1113 - 1120
03/30/1994 Authors: Schinazi RF; Goudgaon NM; Fulcrand G; el Kattan Y; Lesnikowski Z; Ullas G; Moravek J; Liotta DC -
Synthesis, characterization, and biological activity of a new potent class of anti-HIV agents, the peroxoniobium-substituted heteropolytungstates.
J Med Chem Volume: 37 Page(s): 816 - 820
03/18/1994 Authors: Kim GS; Judd DA; Hill CL; Schinazi RF -
Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation.
J Med Chem Volume: 37 Page(s): 821 - 827
03/18/1994 Authors: Shanmuganathan K; Koudriakova T; Nampalli S; Du J; Gallo JM; Schinazi RF; Chu CK -
Pharmacokinetics of antiviral polyoxometalates in rats.
Antimicrob Agents Chemother Volume: 38 Page(s): 504 - 510
03/01/1994 Authors: Ni L; Boudinot FD; Boudinot SG; Henson GW; Bossard GE; Martellucci SA; Ash PW; Fricker SP; Darkes MC; Theobald BR -
EFFECT OF 5(PHENYLSELENYL)ACYCLOURIDINE (PSAU) ON PLASMA URIDINE CONCENTRATION IN FEMALE CD-1 MICE
FASEB JOURNAL Volume: 8 Page(s): A95 - A95
03/01/1994 Authors: NAQUIB FNM; ASHOUR OM; SCHINAZI RF; KHALIFA MMA; RAHEEM MHA; ELKOUNI MH -
Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions.
Antimicrob Agents Chemother Volume: 38 Page(s): 268 - 274
02/01/1994 Authors: Schinazi RF; Lloyd RM; Ramanathan CS; Taylor EW -
Enantiomeric 2',3'-dideoxycytidine derivatives are potent human immunodeficiency virus inhibitors in cell cultures.
C R Acad Sci III Volume: 317 Page(s): 85 - 89
01/01/1994 Authors: Gosselin G; Math C; Bergogne MC; Aubertin AM; Kirn A; Schinazi RF; Sommadossi JP; Imbach JL -
Pharmacokinetics of 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats.
J Pharm Sci Volume: 83 Page(s): 96 - 99
01/01/1994 Authors: Abobo CV; Ni L; Schinazi RF; Liotta DC; Boudinot FD -
Isolation and partial characterization of Cryptosporidium sporozoite and oocyst wall recombinant proteins.
J Eukaryot Microbiol Volume: 41 Page(s): 51S
01/01/1994 Authors: Mead JR; Lloyd RM; You X; Tucker-Burden C; Arrowood MJ; Schinazi RF -
CARBORANYL OLIGONUCLEOTIDES FOR ANTISENSE TECHNOLOGY AND BORON NEUTRON-CAPTURE THERAPY OF CANCERS
Volume: 580 Page(s): 169 - 182
01/01/1994 Authors: SCHINAZI RF; LESNIKOWSKI ZJ; FULCRANDELKATTAN G; WILSON DW -
Effect of genetically determined host factors on the efficacy of vidarabine, acyclovir and 5-trifluorothymidine in herpes simplex virus type 1 infection.
Ophthalmic Res Volume: 26 Page(s): 95 - 104
01/01/1994 Authors: Abghari SZ; Stulting RD; Zhu Z; Schinazi RF; Kaufman HE -
ANTIVIRAL AGENTS
Volume: 29 Page(s): 145 - 154
01/01/1994 Authors: BOEHME RE; BORTHWICK AD; WYATT PG -
Synthesis of dicationic diaryltriazines nucleic acid binding agents.
Eur J Med Chem Volume: 29 Page(s): 363 - 367
01/01/1994 Authors: Spychala J; Boykin D; Wilson W; Zhao M; Tidwell R; Dykstra C; Hall J; Jones S; Schinazi R -
Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase.
J Med Chem Volume: 36 Page(s): 4250 - 4254
12/24/1993 Authors: Goudgaon NM; Naguib FN; el Kouni MH; Schinazi RF -
Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro.
Antimicrob Agents Chemother Volume: 37 Page(s): 2206 - 2211
10/01/1993 Authors: Mathez D; Schinazi RF; Liotta DC; Leibowitch J -
Structure-activity relationships of beta-D-(2S,5R)- and alpha-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents.
J Med Chem Volume: 36 Page(s): 2627 - 2638
09/03/1993 Authors: Jeong LS; Schinazi RF; Beach JW; Kim HO; Shanmuganathan K; Nampalli S; Chun MW; Chung WK; Choi BG; Chu CK -
ENHANCED BRAIN DELIVERY OF ANTI-HIV NUCLEOSIDES
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 206 Page(s): 23 - CARB
08/22/1993 Authors: SHANMUGANATHAN K; KOUDRIAKOVA T; GALLO JM; SCHINAZI RF; CHU CK -
Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene.
Antimicrob Agents Chemother Volume: 37 Page(s): 1707 - 1710
08/01/1993 Authors: Schinazi RF; Sijbesma R; Srdanov G; Hill CL; Wudl F -
Intracellular diversion of glycoprotein GP160 of human immunodeficiency virus to lysosomes as a strategy of AIDS gene therapy.
FASEB J Volume: 7 Page(s): 1070 - 1080
08/01/1993 Authors: Lin X; Dashti A; Schinazi RF; Tang J -
Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol.
Biochem Pharmacol Volume: 46 Page(s): 251 - 255
07/20/1993 Authors: Lin TS; Schinazi RF; Zhu J; Birks E; Carbone R; Si Y; Wu K; Huang L; Prusoff WH -
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase.
Biochem Pharmacol Volume: 45 Page(s): 1540 - 1543
04/06/1993 Authors: Shewach DS; Liotta DC; Schinazi RF -
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.
Antimicrob Agents Chemother Volume: 37 Page(s): 875 - 881
04/01/1993 Authors: Schinazi RF; Lloyd RM; Nguyen MH; Cannon DL; McMillan A; Ilksoy N; Chu CK; Liotta DC; Bazmi HZ; Mellors JW -
Derivatives of 4-amino-3,6-disulfonato-1,8-naphthalimide inhibit reverse transcriptase and suppress human and feline immunodeficiency virus expression in cultured cells.
J Cell Biochem Volume: 51 Page(s): 446 - 457
04/01/1993 Authors: Rideout D; Schinazi R; Pauza CD; Lovelace K; Chiang LC; Calogeropoulou T; McCarthy M; Elder JH -
L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.
J Med Chem Volume: 36 Page(s): 519 - 528
03/05/1993 Authors: Kim HO; Schinazi RF; Shanmuganathan K; Jeong LS; Beach JW; Nampalli S; Cannon DL; Chu CK -
Non-HIV-1 CD4+ lymphocyte depletion in a patient with an acquired immunodeficiency syndrome of unknown etiology.
AIDS Volume: 7 Page(s): 284 - 285
02/01/1993 Authors: Schinazi RF; Del Bene VE -
Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.
J Med Chem Volume: 36 Page(s): 181 - 195
01/22/1993 Authors: Jeong LS; Schinazi RF; Beach JW; Kim HO; Nampalli S; Shanmuganathan K; Alves AJ; McMillan A; Chu CK; Mathis R -
1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.
J Med Chem Volume: 36 Page(s): 30 - 37
01/08/1993 Authors: Kim HO; Schinazi RF; Nampalli S; Shanmuganathan K; Cannon DL; Alves AJ; Jeong LS; Beach JW; Chu CK -
Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys.
Drug Metab Dispos Volume: 21 Page(s): 855 - 860
01/01/1993 Authors: Boudinot FD; Schinazi RF; Doshi KJ; McClure HM; Chu CK -
FAMCICLOVIR-PENCICLOVIR - PHARMACOLOGY AND PHARMACOKINETICS WORKSHOP - PROCEEDINGS OF A MEETING HELD AT CLIVEDEN, MAIDENHEAD, UK, ON 23 APRIL 1993 - DISCUSSION AND CONCLUSIONS
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY Volume: 4 Page(s): 67 - 68
01/01/1993 Authors: BENET LZ; CHENG YC; COEN DM; CRUMPACKER CS; FIELD HJ; KERN ER; OXFORD J; SACKS SL; SAFRIN S; SCHENTAG JJ -
SYNTHESIS, ANTIVIRAL ACTIVITY, CYTOTOXICITY, AND CELLULAR PHARMACOLOGY OF 5-CARBORANYL-PYRIMIDINE NUCLEOSIDES
Page(s): 285 - 288
01/01/1993 Authors: SCHINAZI RF; GOUDGAON N; SORIA J; LIOTTA DC -
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
Antimicrob Agents Chemother Volume: 36 Page(s): 2686 - 2692
12/01/1992 Authors: Furman PA; Davis M; Liotta DC; Paff M; Frick LW; Nelson DJ; Dornsife RE; Wurster JA; Wilson LJ; Fyfe JA -
Comparison of cytotoxicity of the (-)- and (+)-enantiomer of 2',3'-dideoxy-3'-thiacytidine in normal human bone marrow progenitor cells.
Biochem Pharmacol Volume: 44 Page(s): 1921 - 1925
11/17/1992 Authors: Sommadossi JP; Schinazi RF; Chu CK; Xie MY -
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
Antimicrob Agents Chemother Volume: 36 Page(s): 2423 - 2431
11/01/1992 Authors: Schinazi RF; McMillan A; Cannon D; Mathis R; Lloyd RM; Peck A; Sommadossi JP; St Clair M; Wilson J; Furman PA -
Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 36 Page(s): 2432 - 2438
11/01/1992 Authors: Schinazi RF; Boudinot FD; Ibrahim SS; Manning C; McClure HM; Liotta DC -
Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides.
Biochem Pharmacol Volume: 44 Page(s): 973 - 980
09/01/1992 Authors: Cretton EM; Xie MY; Goudgaon NM; Schinazi RF; Chu CK; Sommadossi JP -
ASYMMETRIC SYNTHESES AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF D-DIOXOLANE-PYRIMIDINE AND L-DIOXOLANE-PYRIMIDINE AND PURINE NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 204 Page(s): 139 - MEDI
08/23/1992 Authors: KIM HO; SHANMUGANATHAN K; NAMPALLI S; JEONG LS; BEACH JW; SCHINAZI RF; CHU CK -
STRUCTURE-ACTIVITY-RELATIONSHIPS OF ENANTIOMERICALLY PURE D-OXATHIOLANE-NUCLEOSIDES AND L-OXATHIOLANE-NUCLEOSIDES AS POTENTIAL ANTI-HIV AND ANTI-HBV AGENTS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 204 Page(s): 20 - CARB
08/23/1992 Authors: JEONG LS; BEACH JW; KIM HO; NAMPALLI S; SHANMUGANATHAN K; SCHINAZI RF; CHANG CN; CHENG YC; CHU CK -
HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids.
J Med Chem Volume: 35 Page(s): 2744 - 2752
07/24/1992 Authors: Taraporewala IB; Cessac JW; Chanh TC; Delgado AV; Schinazi RF -
Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.
Biochem Pharmacol Volume: 44 Page(s): 199 - 204
07/22/1992 Authors: Schinazi RF; Peck A; Sommadossi JP -
Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
J Biol Chem Volume: 267 Page(s): 13938 - 13942
07/15/1992 Authors: Chang CN; Doong SL; Zhou JH; Beach JW; Jeong LS; Chu CK; Tsai CH; Cheng YC; Liotta D; Schinazi R -
Insights into HIV chemotherapy.
AIDS Res Hum Retroviruses Volume: 8 Page(s): 963 - 990
06/01/1992 Authors: Schinazi RF; Mead JR; Feorino PM -
Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
J Med Chem Volume: 35 Page(s): 1987 - 1995
05/29/1992 Authors: Kim HO; Ahn SK; Alves AJ; Beach JW; Jeong LS; Choi BG; Van Roey P; Schinazi RF; Chu CK -
SYNTHESIS, PROPERTIES, AND ANTI-HIV-1 ACTIVITY OF LI8P2NB6W18O77
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 203 Page(s): 712 - INOR
04/05/1992 Authors: JAKUPCIAK JP; HILL CL; SCHINAZI RF -
SYNTHESIS OF (-)-L-BETA-BCH-189 FROM L-GULOSE AND ITS ANTI-HIV AND ANTI-HBV ACTIVITY
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 203 Page(s): 50 - CARB
04/05/1992 Authors: BEACH JW; ALVES AJ; JEONG LS; KIM HO; SCHINAZI RF; CHENG YC; CHANG CN; DOONG SL; CHU CK -
Synthesis, characterization, and anti-human immunodeficiency virus activity of water-soluble salts of polyoxotungstate anions with covalently attached organic groups.
J Med Chem Volume: 35 Page(s): 1216 - 1221
04/03/1992 Authors: Weeks MS; Hill CL; Schinazi RF -
Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.
Antimicrob Agents Chemother Volume: 36 Page(s): 672 - 676
03/01/1992 Authors: Schinazi RF; Chu CK; Peck A; McMillan A; Mathis R; Cannon D; Jeong LS; Beach JW; Choi WB; Yeola S -
INTRACELLULAR DIVERSION OF ENVELOPE GLYCOPROTEIN GP160 OF HUMAN-IMMUNODEFICIENCY-VIRUS TO LYSOSOMES FOR DEGRADATION
FASEB JOURNAL Volume: 6 Page(s): A224 - A224
01/01/1992 Authors: LIN XL; DASHTI A; SCHINAZI RF; TANG J -
PROGRESS IN THE DEVELOPMENT OF NATURAL-PRODUCTS FOR HUMAN IMMUNODEFICIENCY VIRUSES INFECTIONS
Page(s): 1 - 29
01/01/1992 Authors: SCHINAZI RF -
Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1.
Antimicrob Agents Chemother Volume: 36 Page(s): 108 - 114
01/01/1992 Authors: Bardos TJ; Schinazi RF; Ling KH; Heider AR -
Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes.
J Med Chem Volume: 34 Page(s): 3305 - 3309
11/01/1991 Authors: Goudgaon NM; Schinazi RF -
Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
Proc Natl Acad Sci U S A Volume: 88 Page(s): 8495 - 8499
10/01/1991 Authors: Doong SL; Tsai CH; Schinazi RF; Liotta DC; Cheng YC -
ADVANCES IN ANTIVIRAL CHEMOTHERAPY
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 202 Page(s): 162 - AGFD
08/25/1991 Authors: SCHINAZI RF -
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ENANTIOMERICALLY PURE DIOXOLANE-PYRIMIDINE NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 202 Page(s): 51 - MEDI
08/25/1991 Authors: KIM HO; AHN SK; ALVES A; CHOI BG; BEACH JW; SCHINAZI RF; VANROEY P; CHU CK -
ASYMMETRIC-SYNTHESIS OF (+)-BCH-189 USING D-MANNOSE AS A CHIRAL TEMPLATE AND ITS ANTI-HIV ACTIVITY IN PBM CELLS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 202 Page(s): 22 - CARB
08/25/1991 Authors: BEACH JW; COMER FI; JEONG LS; VANROEY P; SCHINAZI RF; CHU CK -
Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys.
Antimicrob Agents Chemother Volume: 35 Page(s): 801 - 807
05/01/1991 Authors: Cretton EM; Schinazi RF; McClure HM; Anderson DC; Sommadossi JP -
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents.
J Med Chem Volume: 34 Page(s): 1739 - 1746
05/01/1991 Authors: Strekowski L; Mokrosz JL; Honkan VA; Czarny A; Cegla MT; Wydra RL; Patterson SE; Schinazi RF -
AN ASYMMETRIC-SYNTHESIS OF ENANTIOMERICALLY PURE (-)-DIOXOLANE-THYMINE AND ITS ANTI-HIV ACTIVITY
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 201 Page(s): 29 - CARB
04/14/1991 Authors: AHN SK; KIM HO; BEACH JW; ALVES AJ; JEONG LS; ISLAM Q; SCHINAZI RF; CHU CK -
PORPHYRINS - NEW AGENTS AGAINST THE HUMAN-IMMUNODEFICIENCY-VIRUS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 201 Page(s): 38 - MEDI
04/14/1991 Authors: OBARA G; DIXON DW; SCHINAZI R; MARZILLI LG -
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.
Antimicrob Agents Chemother Volume: 35 Page(s): 747 - 749
04/01/1991 Authors: Boudinot FD; Smith SG; Funderburg ED; Schinazi RF -
Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.
Mol Pharmacol Volume: 39 Page(s): 258 - 266
02/01/1991 Authors: Cretton EM; Xie MY; Bevan RJ; Goudgaon NM; Schinazi RF; Sommadossi JP -
INVITRO TESTING OF THERAPEUTICS AGAINST SIV AND HIV - A COMPARISON
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Volume: 616 Page(s): 599 - 605
12/26/1990 Authors: SAGER PR; CRADOCK JC; LITTERST CL; MARTIN LN; SOIKE KF; MURPHEYCORB M; MARX PA; TSAI CC; FRIDLAND A; BODNER A -
Pharmacokinetics of 3 '-azido-2 ',3 '-dideoxy-5-methylcytidine in rats
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY Volume: 1 Page(s): 367 - 371
12/01/1990 Authors: Boudinot FD; Ibrahim SS; Qin Y; Chu CK; Schinazi RF -
Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.
Mol Pharmacol Volume: 38 Page(s): 929 - 938
12/01/1990 Authors: Zhu Z; Schinazi RF; Chu CK; Williams GJ; Colby CB; Sommadossi JP -
Anti-HIV-1 activity, toxicity, and stability studies of representative structural families of polyoxometalates.
J Med Chem Volume: 33 Page(s): 2767 - 2772
10/01/1990 Authors: Hill CL; Weeks MS; Schinazi RF -
Synthesis and anti-human immunodeficiency virus (HIV-1) activity of 3'-deoxy-3'-(triazol-1-yl)thymidines and 2',3'-dideoxy-3'-(triazol-1-yl)uridines and inhibition of reverse transcriptase by their 5'-triphosphates.
Chem Pharm Bull (Tokyo) Volume: 38 Page(s): 2597 - 2601
09/01/1990 Authors: Hirota K; Hosono H; Kitade Y; Maki Y; Chu CK; Schinazi RF; Nakane H; Ono K -
SYNTHESIS OF AZDU-DIPHOSPHOHEXOSES AS POTENTIAL ANTI-HIV PRODRUGS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 200 Page(s): 18 - CARB
08/26/1990 Authors: ISLAM Q; SCHINAZI RF; SOMMADOSSI JP; CHU CK -
SYNTHESIS AND EVALUATION OF 3'-AZIDO ANALOGS OF PURINE NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 200 Page(s): 32 - CARB
08/26/1990 Authors: JEONG LS; BEACH JW; SCHINAZI RF; CHU CK -
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.
J Med Chem Volume: 33 Page(s): 2188 - 2192
08/01/1990 Authors: Chu CK; Bhadti VS; Doshi KJ; Etse JT; Gallo JM; Boudinot FD; Schinazi RF -
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.
Antimicrob Agents Chemother Volume: 34 Page(s): 1214 - 1219
06/01/1990 Authors: Schinazi RF; Boudinot FD; Doshi KJ; McClure HM -
Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.
Antimicrob Agents Chemother Volume: 34 Page(s): 1061 - 1067
06/01/1990 Authors: Schinazi RF; Sommadossi JP; Saalmann V; Cannon DL; Xie MY; Hart GC; Smith GA; Hahn EF -
Synthesis and structure-activity relationships of 6-substituted 2',3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents.
J Med Chem Volume: 33 Page(s): 1553 - 1561
06/01/1990 Authors: Chu CK; Ullas GV; Jeong LS; Ahn SK; Doboszewski B; Lin ZX; Beach JW; Schinazi RF -
Anthraquinones as a new class of antiviral agents against human immunodeficiency virus.
Antiviral Res Volume: 13 Page(s): 265 - 272
05/01/1990 Authors: Schinazi RF; Chu CK; Babu JR; Oswald BJ; Saalmann V; Cannon DL; Eriksson BF; Nasr M -
The crystal and molecular structure of 3 '-fluoro-3 '-deoxythymidine, a potent anti-HIV-1 nucleoside
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY Volume: 1 Page(s): 93 - 98
04/01/1990 Authors: Van Roey P; Schinazi RF -
Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.
J Pharmacobiodyn Volume: 13 Page(s): 206 - 211
03/01/1990 Authors: Patel BA; Boudinot FD; Schinazi RF; Gallo JM; Chu CK -
3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.
AIDS Res Hum Retroviruses Volume: 6 Page(s): 219 - 228
02/01/1990 Authors: Boudinot FD; Schinazi RF; Gallo JM; McClure HM; Anderson DC; Doshi KJ; Kambhampathi PC; Chu CK -
DIPYRIDAMOLE HAS ACTIVITY AGAINST HIV-1 AND POTENTIATES THE ANTIVIRAL EFFECTS OF ZIDOVUDINE AND OTHER DIDEOXYNUCLEOSIDES INVITRO
AIDS RESEARCH AND HUMAN RETROVIRUSES Volume: 6 Page(s): 129 - 130
01/01/1990 Authors: WEINSTEIN JN; GARTNER S; POPOVIC M; WAHL SM; WAHL LM; BETAGERI G; SCHINAZI RF; FINE RL; WEISLOW OS; SZEBENI J -
Nonhuman primate models for evaluation of AIDS therapy.
Ann N Y Acad Sci Volume: 616 Page(s): 287 - 298
01/01/1990 Authors: McClure HM; Anderson DC; Ansari AA; Fultz PN; Klumpp SA; Schinazi RF -
Correlation of molecular conformation and activity of reverse transcriptase inhibitors.
Ann N Y Acad Sci Volume: 616 Page(s): 29 - 40
01/01/1990 Authors: Van Roey P; Taylor EW; Chu CK; Schinazi RF -
Terminal transferase as a therapeutic target in leukemia cells.
Prog Clin Biol Res Volume: 352 Page(s): 409 - 416
01/01/1990 Authors: McCaffrey R; Duff R; Bulger K; Spigelman Z; Flora K; Schinazi R; Chu CK -
Synergistic drug combinations in AIDS therapy. Dipyridamole/3'-azido-3'-deoxythymidine in particular and principles of analysis in general.
Ann N Y Acad Sci Volume: 616 Page(s): 367 - 384
01/01/1990 Authors: Weinstein JN; Bunow B; Weislow OS; Schinazi RF; Wahl SM; Wahl LM; Szebeni J -
Antiretroviral activity, biochemistry, and pharmacokinetics of 3'-azido-2',3'-dideoxy-5-methylcytidine.
Ann N Y Acad Sci Volume: 616 Page(s): 385 - 397
01/01/1990 Authors: Schinazi RF; Chu CK; Eriksson BF; Sommadossi JP; Doshi KJ; Boudinot FD; Oswald B; McClure HM -
Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.
Antimicrob Agents Chemother Volume: 33 Page(s): 2149 - 2151
12/01/1989 Authors: Lin TS; Schinazi R; Griffith BP; August EM; Eriksson BF; Zheng DK; Huang LA; Prusoff WH -
Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.
Antimicrob Agents Chemother Volume: 33 Page(s): 1729 - 1734
10/01/1989 Authors: Eriksson BF; Chu CK; Schinazi RF -
Correlation between preferred sugar ring conformation and activity of nucleoside analogues against human immunodeficiency virus.
Proc Natl Acad Sci U S A Volume: 86 Page(s): 3929 - 3933
06/01/1989 Authors: Van Roey P; Salerno JM; Chu CK; Schinazi RF -
Combinations of 3'-azido-3'-deoxythymidine (zidovudine) and phosphonoformate (foscarnet) against human immunodeficiency virus type 1 and cytomegalovirus replication in vitro.
Antimicrob Agents Chemother Volume: 33 Page(s): 663 - 669
05/01/1989 Authors: Eriksson BF; Schinazi RF -
Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
J Med Chem Volume: 32 Page(s): 612 - 617
03/01/1989 Authors: Chu CK; Schinazi RF; Ahn MK; Ullas GV; Gu ZP -
Comparison of inhibitory activities of various antiretroviral agents against particle-derived and recombinant human immunodeficiency virus type 1 reverse transcriptases.
Antimicrob Agents Chemother Volume: 33 Page(s): 115 - 117
01/01/1989 Authors: Schinazi RF; Eriksson BF; Hughes SH -
Acyclic analogues of 3'-azido-3'-deoxythymidine as potential antiviral agents. Nucleoside synthesis by Michael addition.
J Med Chem Volume: 32 Page(s): 73 - 76
01/01/1989 Authors: Scheiner P; Geer A; Bucknor AM; Imbach JL; Schinazi RF -
Comparative pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU) in mice.
Drug Metab Dispos Volume: 17 Page(s): 590 - 594
01/01/1989 Authors: Doshi KJ; Gallo JM; Boudinot FD; Schinazi RF; Chu CK -
Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1.
Antimicrob Agents Chemother Volume: 32 Page(s): 1784 - 1787
12/01/1988 Authors: Schinazi RF; Cannon DL; Arnold BH; Martino-Saltzman D -
Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Biochem Pharmacol Volume: 37 Page(s): 3543 - 3548
10/01/1988 Authors: Chu CK; Schinazi RF; Arnold BH; Cannon DL; Doboszewski B; Bhadti VB; Gu ZP -
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
Antimicrob Agents Chemother Volume: 32 Page(s): 997 - 1001
07/01/1988 Authors: Sommadossi JP; Carlisle R; Schinazi RF; Zhou Z -
Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).
J Med Chem Volume: 31 Page(s): 336 - 340
02/01/1988 Authors: Lin TS; Guo JY; Schinazi RF; Chu CK; Xiang JN; Prusoff WH -
ANTIVIRAL ACTIVITIES OF 2'-FLUORINATED ARABINOSYL PYRIMIDINE NUCLEOSIDES
ACS SYMPOSIUM SERIES Volume: 374 Page(s): 176 - 190
01/01/1988 Authors: FOX JJ; WATANABE KA; CHOU TC; SCHINAZI RF; SOIKE KF; FOUREL I; HANTZ G; TREPO C -
CORRELATION OF ANTIRETROVIRAL AGENTS ACTIVITY AGAINST HIV-1 AND SIV - IMPLICATIONS FOR STUDIES IN NON-HUMAN PRIMATE MODELS
ANTIVIRAL RESEARCH Volume: 9 Page(s): 133 - 133
01/01/1988 Authors: SCHINAZI RF; ERIKSSON BFH; CHU CK; HILL CL; ARNOLD BH; CANNON DL; MCCLURE H; ANDERSON D; FULTZ P -
INHIBITION OF HIV-1 AND SIMIAN IMMUNODEFICIENCY VIRUS (SIV) REVERSE TRANSCRIPTASES BY THE 5'-TRIPHOSPHATES OF 3'-AZIDO-2',3'-DIDEOXYURIDINE (CS-87), 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT), AND 3'-AZIDO-2',3'-DIDEOXY-5-ETHYLURIDINE (CS-85)
ANTIVIRAL RESEARCH Volume: 9 Page(s): 84 - 84
01/01/1988 Authors: ERIKSSON BFH; SCHINAZI RF; CHU CK -
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
Biochem Pharmacol Volume: 36 Page(s): 2713 - 2718
09/01/1987 Authors: Lin TS; Schinazi RF; Prusoff WH -
Human immunodeficiency virus isolated from amniotic fluid.
Lancet Volume: 2 Page(s): 459 - 460
08/22/1987 Authors: Mundy DC; Schinazi RF; Gerber AR; Nahmias AJ; Randall HW -
Drug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virus.
Antimicrob Agents Chemother Volume: 31 Page(s): 477 - 479
03/01/1987 Authors: Schinazi RF -
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
Biochem Pharmacol Volume: 36 Page(s): 311 - 316
02/01/1987 Authors: Lin TS; Schinazi RF; Chen MS; Kinney-Thomas E; Prusoff WH -
5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents.
Nucleic Acids Symp Ser Page(s): 261 - 264
01/01/1987 Authors: Huang JT; Schinazi RF; Gadler H; Price RW; Su TL; Watanabe KA -
Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.
J Med Chem Volume: 30 Page(s): 226 - 229
01/01/1987 Authors: Harada K; Matulic-Adamic J; Price RW; Schinazi RF; Watanabe KA; Fox JJ -
Characterization of acyclovir-resistant and -sensitive herpes simplex viruses isolated from a patient with an acquired immune deficiency.
J Antimicrob Chemother Volume: 18 Suppl B Page(s): 127 - 134
10/01/1986 Authors: Schinazi RF; del Bene V; Scott RT; Dudley-Thorpe JB -
Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis.
Antimicrob Agents Chemother Volume: 30 Page(s): 491 - 498
09/01/1986 Authors: Schinazi RF; Chou TC; Scott RT; Yao XJ; Nahmias AJ -
Synthesis and biological activity of 5-phenylselenenyl-substituted pyrimidine nucleosides.
J Med Chem Volume: 29 Page(s): 1293 - 1295
07/01/1986 Authors: Schinazi RF; Arbiser J; Lee JJ; Kalman TI; Prusoff WH -
Nucleosides. 136. Synthesis and antiviral effects of several 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-alkyluracils. Some structure-activity relationships.
J Med Chem Volume: 29 Page(s): 151 - 154
01/01/1986 Authors: Su TL; Watanabe KA; Schinazi RF; Fox JJ -
Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.
Antimicrob Agents Chemother Volume: 29 Page(s): 77 - 84
01/01/1986 Authors: Schinazi RF; Fox JJ; Watanabe KA; Nahmias AJ -
Antiviral activity of 5-ethyl-2'-deoxyuridine against herpes simplex viruses in cell culture, mice, and guinea pigs.
Antimicrob Agents Chemother Volume: 28 Page(s): 552 - 560
10/01/1985 Authors: Schinazi RF; Scott RT; Peters J; Rice V; Nahmias AJ -
Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
J Med Chem Volume: 28 Page(s): 741 - 748
06/01/1985 Authors: Perlman ME; Watanabe KA; Schinazi RF; Fox JJ -
CORRECTION
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Volume: 28 Page(s): 851 - 851
01/01/1985 Authors: SCHINAZI RF -
Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus.
Antiviral Res Volume: 4 Page(s): 259 - 270
10/01/1984 Authors: Schat KA; Schinazi RF; Calnek BW -
Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.
Antimicrob Agents Chemother Volume: 24 Page(s): 95 - 103
07/01/1983 Authors: Schinazi RF; Peters J; Sokol MK; Nahmias AJ -
Antiviral agents.
Pediatr Clin North Am Volume: 30 Page(s): 77 - 92
02/01/1983 Authors: Schinazi RF; Prusoff WH -
Crystal structure and anti herpes simplex virus activity of 2,2'-anhydro-1-beta-D-arabinofuranosylthymine.
J Med Chem Volume: 25 Page(s): 1507 - 1510
12/01/1982 Authors: Harrison DH; Schinazi RF; Rubin BH -
Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.
J Virol Methods Volume: 5 Page(s): 209 - 217
11/01/1982 Authors: Cheng YC; Schinazi RF; Dutschman GE; Tan RS; Grill SP -
Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.
Antimicrob Agents Chemother Volume: 22 Page(s): 499 - 507
09/01/1982 Authors: Schinazi RF; Peters J; Williams CC; Chance D; Nahmias AJ -
Different in vitro effects of dual combinations of anti-herpes simplex virus compounds.
Am J Med Volume: 73 Page(s): 40 - 48
07/20/1982 Authors: Schinazi RF; Nahmias AJ -
Antiviral drugs: modes of action and strategies for therapy.
Hosp Pract (Off Ed) Volume: 16 Page(s): 113 - 124
06/01/1981 Authors: Schinazi RF; Prusoff WH -
Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2.
Antimicrob Agents Chemother Volume: 19 Page(s): 672 - 674
04/01/1981 Authors: Stanwick TL; Schinazi RF; Campbell DE; Nahmias AJ -
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
J Med Chem Volume: 23 Page(s): 127 - 133
02/01/1980 Authors: Shiau GT; Schinazi RF; Chen MS; Prusoff WH -
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
J Med Chem Volume: 22 Page(s): 1273 - 1277
10/01/1979 Authors: Schinazi RF; Chen MS; Prusoff WH -
Role of nucleosides in virus and cancer chemotherapy.
Adv Ophthalmol Volume: 38 Page(s): 3 - 16
01/01/1979 Authors: Prusoff WH; Chen MS; Fischer PH; Lin TS; Shiau GT; Schinazi RF -
Antiviral iodinated pyrimidine deoxyribonucleosides: 5-iodo-2'-deoxyuridine; 5-iodo-2'-deoxycytidine; 5-iodo-5'-amino-2',5'-dideoxyuridine.
Pharmacol Ther Volume: 7 Page(s): 1 - 34
01/01/1979 Authors: Prusoff WH; Chen MS; Fischer PH; Lin TS; Shiau GT; Schinazi RF; Walker J -
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
J Med Chem Volume: 21 Page(s): 1141 - 1146
11/01/1978 Authors: Schinazi RF; Chen MS; Prusoff WH -
SYNTHESIS OF 5'-AMINO DERIVATIVES OF BETA-D-ARABINOFURANOSYLPYRIMIDINES
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 176 Page(s): 14 - 14
01/01/1978 Authors: SCHINAZI RF; CHEN MS; PRUSOFF WH -
SYNTHESIS OF 5-DIHYDROXYBORYL-2'-DEOXYURIDINE AND RELATED BORON-CONTAINING PYRIMIDINES
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 176 Page(s): 38 - 38
01/01/1978 Authors: SCHINAZI RF; PRUSOFF WH -
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME (2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL-URONIC ACID)-PYRIMIDINES, 2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL-URONAMIDE-PYRIMIDINES, AND 2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL-URONONITRILE-PYRIMIDINES
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 174 Page(s): 20 - 20
01/01/1977 Authors: SCHINAZI RF; PRUSOFF WH