Richard Plemper

Department of Pediatrics
Adjunct Professor

(404) 727-3228
richard.plemper@emory.edu

Academic Appointment

Education

Degrees

PhD from University of Stuttgart
MSc from University of Stuttgart

Research

Focus

Studying myxoviruses (orthomyxo and paramyxovirus families), research in my laboratory is directed towards two major goals: (1) to better understand molecular determinants for entry and replication of clinically relevant myxoviruses, and (2) apply this knowledge to the identification of innovative myxovirus inhibitors through template- based drug design and automated drug screening.

Publications

A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants.
bioRxiv
05/13/2025 Authors: Ma Y; Ye C; Khalil AM; Mahmoud SH; Sobolik EB; Greninger AL; Castro E; Jackson N; Bayoumi M; Plemper RK
Tetracistronic minigenomes elucidate a functional promoter for Ghana virus and unveils Cedar virus replicase promiscuity for all henipaviruses.
J Virol Volume: 98 Page(s): e0080624
10/22/2024 Authors: Haas GD; Kowdle S; Schmitz KS; Azarm KD; Johnson KN; Klain WR; Freiberg AN; Cox RM; Plemper RK; Lee B
A three-way interface of the Nipah virus phosphoprotein X-domain coordinates polymerase movement along the viral genome.
J Virol Volume: 98 Page(s): e0098624
10/22/2024 Authors: Wolf JD; Plemper RK
Structural basis of paramyxo- and pneumovirus polymerase inhibition by non-nucleoside small-molecule antivirals.
Antimicrob Agents Chemother Volume: 68 Page(s): e0080024
10/08/2024 Authors: Wolf JD; Sirrine MR; Cox RM; Plemper RK
Efficacy of late-onset antiviral treatment in immunocompromised hosts with persistent SARS-CoV-2 infection.
J Virol Volume: 98 Page(s): e0090524
09/17/2024 Authors: Lieber CM; Kang H-J; Sobolik EB; Sticher ZM; Ngo VL; Gewirtz AT; Kolykhalov AA; Natchus MG; Greninger AL; Suthar MS
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo.
Nat Commun Volume: 15 Page(s): 6503
08/01/2024 Authors: Rhodin MHJ; Reyes AC; Balakrishnan A; Bisht N; Kelly NM; Gibbons JS; Lloyd J; Vaine M; Cressey T; Crepeau M
Anti-SARS-CoV-2 antibodies in a nasal spray efficiently block viral transmission between ferrets.
iScience Volume: 27 Page(s): 110326
07/19/2024 Authors: Gildemann K; Tsernant M-L; Liivand L; Ennome R; Poikalainen V; Lepasalu L; Rom S; Kavak A; Cox RM; Wolf JD
Efficacy of late-onset antiviral treatment in immune-compromised hosts with persistent SARS-CoV-2 infection.
bioRxiv
05/23/2024 Authors: Lieber CM; Kang H-J; Sobolik EB; Sticher ZM; Ngo VL; Gewirtz AT; Kolykhalov AA; Natchus MG; Greninger AL; Suthar MS
Intestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infection.
Cell Host Microbe Volume: 32 Page(s): 335 - 348.e8
03/13/2024 Authors: Ngo VL; Lieber CM; Kang H-J; Sakamoto K; Kuczma M; Plemper RK; Gewirtz AT
Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets.
Nat Commun Volume: 15 Page(s): 1189
02/08/2024 Authors: Cox RM; Wolf JD; Lieberman NA; Lieber CM; Kang H-J; Sticher ZM; Yoon J-J; Andrews MK; Govindarajan M; Krueger RE
Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo.
PLoS Pathog Volume: 20 Page(s): e1011993
02/01/2024 Authors: Lieber CM; Kang H-J; Aggarwal M; Lieberman NA; Sobolik EB; Yoon J-J; Natchus MG; Cox RM; Greninger AL; Plemper RK
Design and Execution of In Vitro Polymerase Assays for Measles Virus and Related Mononegaviruses.
Methods Mol Biol Volume: 2808 Page(s): 19 - 33
01/01/2024 Authors: Cox RM; Plemper RK
Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 Mpro Inhibitors.
ACS Med Chem Lett Volume: 14 Page(s): 1434 - 1440
10/12/2023 Authors: Jacobs L; van der Westhuyzen A; Pribut N; Dentmon ZW; Cui D; D'Erasmo MP; Bartsch PW; Liu K; Cox RM; Greenlund SF
Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models.
Nat Commun Volume: 14 Page(s): 4731
08/07/2023 Authors: Cox RM; Lieber CM; Wolf JD; Karimi A; Lieberman NAP; Sticher ZM; Roychoudhury P; Andrews MK; Krueger RE; Natchus MG
Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota).
J Gen Virol Volume: 104
08/01/2023 Authors: Kuhn JH; Abe J; Adkins S; Alkhovsky SV; Avi-upanc T; Aylln MA; Bahl J; Balkema-Buschmann A; Ballinger MJ; Kumar Baranwal V
Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission.
Microbiol Spectr Volume: 11 Page(s): e0065323
06/15/2023 Authors: Ye C; Park J-G; Chiem K; Dravid P; Allu-Guardia A; Garcia-Vilanova A; Pino Tamayo P; Shivanna V; Kapoor A; Walter MR
Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus.
Nat Microbiol Volume: 8 Page(s): 1108 - 1122
06/01/2023 Authors: Ikegame S; Carmichael JC; Wells H; Furler O'Brien RL; Acklin JA; Chiu H-P; Oguntuyo KY; Cox RM; Patel AR; Kowdle S
Virology under the Microscope-a Call for Rational Discourse.
mSphere Volume: 8 Page(s): e0003423
04/20/2023 Authors: Goodrum F; Lowen AC; Lakdawala S; Alwine J; Casadevall A; Imperiale MJ; Atwood W; Avgousti D; Baines J; Banfield B
4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses.
PLoS Pathog Volume: 19 Page(s): e1011342
04/01/2023 Authors: Lieber CM; Aggarwal M; Yoon J-J; Cox RM; Kang H-J; Sourimant J; Toots M; Johnson SK; Jones CA; Sticher ZM
Virology under the Microscope-a Call for Rational Discourse.
mBio Volume: 14 Page(s): e0018823
02/28/2023 Authors: Goodrum F; Lowen AC; Lakdawala S; Alwine J; Casadevall A; Imperiale MJ; Atwood W; Avgousti D; Baines J; Banfield B
Virology under the Microscope-a Call for Rational Discourse.
J Virol Volume: 97 Page(s): e0008923
02/28/2023 Authors: Goodrum F; Lowen AC; Lakdawala S; Alwine J; Casadevall A; Imperiale MJ; Atwood W; Avgousti D; Baines J; Banfield B
2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.
Arch Virol Volume: 167 Page(s): 2857 - 2906
12/01/2022 Authors: Kuhn JH; Adkins S; Alkhovsky SV; Avi-upanc T; Aylln MA; Bahl J; Balkema-Buschmann A; Ballinger MJ; Bandte M; Beer M
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus.
Microbiol Spectr Volume: 10 Page(s): e0237922
10/26/2022 Authors: Chiem K; Park J-G; Morales Vasquez D; Plemper RK; Torrelles JB; Kobie JJ; Walter MR; Ye C; Martinez-Sobrido L
4'-Fluorouridine Is a Broad-Spectrum Orally Available First-Line Antiviral That May Improve Pandemic Preparedness.
DNA Cell Biol Volume: 41 Page(s): 699 - 704
08/01/2022 Authors: Lieber CM; Plemper RK
SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model.
Nat Commun Volume: 13 Page(s): 4416
07/29/2022 Authors: Lieber CM; Cox RM; Sourimant J; Wolf JD; Juergens K; Phung Q; Saindane MT; Smith MK; Sticher ZM; Kalykhalov AA
Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase.
Sci Adv Volume: 8 Page(s): eabo2236
06/24/2022 Authors: Sourimant J; Lieber CM; Yoon J-J; Toots M; Govindarajan M; Udumula V; Sakamoto K; Natchus MG; Patti J; Vernachio J
Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice.
J Virol Volume: 96 Page(s): e0218421
03/23/2022 Authors: Wong TY; Horspool AM; Russ BP; Ye C; Lee KS; Winters MT; Bevere JR; Miller OA; Rader NA; Cooper M
4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication.
Science Volume: 375 Page(s): 161 - 167
01/14/2022 Authors: Sourimant J; Lieber CM; Aggarwal M; Cox RM; Wolf JD; Yoon J-J; Toots M; Ye C; Sticher Z; Kolykhalov AA
Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection.
Gut Microbes Volume: 14 Page(s): 2105609
01/01/2022 Authors: Brown JA; Sanidad KZ; Lucotti S; Lieber CM; Cox RM; Ananthanarayanan A; Basu S; Chen J; Shan M; Amir M
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets.
Nat Commun Volume: 12 Page(s): 6415
11/05/2021 Authors: Cox RM; Wolf JD; Lieber CM; Sourimant J; Lin MJ; Babusis D; DuPont V; Chan J; Barrett KT; Lye D
A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo.
J Virol Volume: 95 Page(s): e0112621
10/27/2021 Authors: Chiem K; Morales Vasquez D; Silvas JA; Park J-G; Piepenbrink MS; Sourimant J; Lin MJ; Greninger AL; Plemper RK; Torrelles JB
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses.
Proc Natl Acad Sci U S A Volume: 118
10/12/2021 Authors: Ye C; Chiem K; Park J-G; Silvas JA; Morales Vasquez D; Sourimant J; Lin MJ; Greninger AL; Plemper RK; Torrelles JB
Editorial overview: Special issue on antiviral strategies in Current Opinion in Virology.
Curr Opin Virol Volume: 50 Page(s): 95 - 96
10/01/2021 Authors: Plemper RK
Zoonotic potential of a novel bat morbillivirus.
Res Sq
09/29/2021 Authors: Lee B; Ikegame S; Carmichael J; Wells H; Furler R; Acklin J; Chiu H-P; Oguntuyo K; Cox R; Patel A
Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding.
Nat Commun Volume: 12 Page(s): 5233
09/02/2021 Authors: Wittwer K; Anderson DE; Pfeffermann K; Cox RM; Wolf JD; Santibanez S; Mankertz A; Plesker R; Sticher ZM; Kolkykhalov AA
Progress and pitfalls of a year of drug repurposing screens against COVID-19.
Curr Opin Virol Volume: 49 Page(s): 183 - 193
08/01/2021 Authors: Sourimant J; Aggarwal M; Plemper RK
The impact of high-resolution structural data on stemming the COVID-19 pandemic.
Curr Opin Virol Volume: 49 Page(s): 127 - 138
08/01/2021 Authors: Cox RM; Plemper RK
SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy.
bioRxiv
05/05/2021 Authors: Horspool AM; Ye C; Wong TY; Russ BP; Lee KS; Winters MT; Bevere JR; Kieffer T; Martinez I; Sourimant J
Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.
PLoS Pathog Volume: 17 Page(s): e1009371
02/01/2021 Authors: Cox RM; Sourimant J; Govindarajan M; Natchus MG; Plemper RK
Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets.
Nat Microbiol Volume: 6 Page(s): 11 - 18
01/01/2021 Authors: Cox RM; Wolf JD; Plemper RK
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness.
PLoS Comput Biol Volume: 16 Page(s): e1008451
12/01/2020 Authors: Sego TJ; Aponte-Serrano JO; Ferrari Gianlupi J; Heaps SR; Breithaupt K; Brusch L; Crawshaw J; Osborne JM; Quardokus EM; Plemper RK
Therapeutic MK-4482/EIDD-2801 Blocks SARS-CoV-2 Transmission in Ferrets.
Res Sq
10/12/2020 Authors: Cox RM; Wolf JD; Plemper RK
High-Throughput Screening Assay to Identify Small Molecule Inhibitors of Marburg Virus VP40 Protein.
ACS Infect Dis Volume: 6 Page(s): 2783 - 2799
10/09/2020 Authors: Luthra P; Anantpadma M; De S; Sourimant J; Davey RA; Plemper RK; Basler CF
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase.
Nat Microbiol Volume: 5 Page(s): 1232 - 1246
10/01/2020 Authors: Cox RM; Sourimant J; Toots M; Yoon J-J; Ikegame S; Govindarajan M; Watkinson RE; Thibault P; Makhsous N; Lin MJ
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness: A multiscale model of viral infection in epithelial tissues.
bioRxiv
09/26/2020 Authors: Sego TJ; Aponte-Serrano JO; Gianlupi JF; Heaps SR; Breithaupt K; Brusch L; Crawshaw J; Osborne JM; Quardokus EM; Plemper RK
Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor.
J Virol Volume: 94
06/16/2020 Authors: Du Pont V; Wirblich C; Yoon J-J; Cox RM; Schnell MJ; Plemper RK
Next-generation direct-acting influenza therapeutics.
Transl Res Volume: 220 Page(s): 33 - 42
06/01/2020 Authors: Toots M; Plemper RK
Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus.
ACS Infect Dis Volume: 6 Page(s): 922 - 929
05/08/2020 Authors: Pribut N; Kaiser TM; Wilson RJ; Jecs E; Dentmon ZW; Pelly SC; Sharma S; Bartsch PW; Burger PB; Hwang SS
Measles Resurgence and Drug Development.
Curr Opin Virol Volume: 41 Page(s): 8 - 17
04/01/2020 Authors: Plemper RK
Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model.
Transl Res Volume: 218 Page(s): 16 - 28
04/01/2020 Authors: Toots M; Yoon J-J; Hart M; Natchus MG; Painter GR; Plemper RK
Structural Insight into Paramyxovirus and Pneumovirus Entry Inhibition.
Viruses Volume: 12
03/20/2020 Authors: Aggarwal M; Plemper RK
Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner.
ACS Infect Dis Volume: 6 Page(s): 489 - 502
03/13/2020 Authors: Edwards MR; Liu G; De S; Sourimant J; Pietzsch C; Johnson B; Amarasinghe GK; Leung DW; Bukreyev A; Plemper RK
Viral evolution identifies a regulatory interface between paramyxovirus polymerase complex and nucleocapsid that controls replication dynamics.
Sci Adv Volume: 6 Page(s): eaaz1590
03/01/2020 Authors: Sourimant J; Thakkar VD; Cox RM; Plemper RK
Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia.
Sci Transl Med Volume: 11
10/23/2019 Authors: Toots M; Yoon J-J; Cox RM; Hart M; Sticher ZM; Makhsous N; Plesker R; Barrena AH; Reddy PG; Mitchell DG
Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection.
Cell Volume: 179 Page(s): 644 - 658.e13
10/17/2019 Authors: Shi Z; Zou J; Zhang Z; Zhao X; Noriega J; Zhang B; Zhao C; Ingle H; Bittinger K; Mattei LM
Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics.
PLoS Pathog Volume: 15 Page(s): e1007995
08/01/2019 Authors: Du Pont V; Jiang Y; Plemper RK
Editorial overview: Antiviral strategies: Antiviral drug development for single-stranded RNA viruses.
Curr Opin Virol Volume: 35 Page(s): iii - v
04/01/2019 Authors: Brinton MA; Plemper RK
Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses.
Curr Opin Virol Volume: 35 Page(s): 1 - 13
04/01/2019 Authors: Du Pont V; Plemper RK; Schnell MJ
Primary resistance mechanism of the canine distemper virus fusion protein against a small-molecule membrane fusion inhibitor.
Virus Res Volume: 259 Page(s): 28 - 37
01/02/2019 Authors: Kalbermatter D; Shrestha N; Ader-Ebert N; Herren M; Moll P; Plemper RK; Altmann K-H; Langedijk JP; Gall F; Lindenmann U
Engineered Small-Molecule Control of Influenza A Virus Replication.
J Virol Volume: 93
01/01/2019 Authors: Fay EJ; Aron SL; Stone IA; Waring BM; Plemper RK; Langlois RA
Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.
J Biol Chem Volume: 293 Page(s): 16761 - 16777
10/26/2018 Authors: Cox RM; Toots M; Yoon J-J; Sourimant J; Ludeke B; Fearns R; Bourque E; Patti J; Lee E; Vernachio J
Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.
Antimicrob Agents Chemother Volume: 62
08/01/2018 Authors: Yoon J-J; Toots M; Lee S; Lee M-E; Ludeke B; Luczo JM; Ganti K; Cox RM; Sticher ZM; Edpuganti V
Biology must develop herd immunity against bad-actor molecules.
PLoS Pathog Volume: 14 Page(s): e1007038
06/01/2018 Authors: Plemper RK; Cox RM
Promotion of virus assembly and organization by the measles virus matrix protein.
Nat Commun Volume: 9 Page(s): 1736
04/30/2018 Authors: Ke Z; Strauss JD; Hampton CM; Brindley MA; Dillard RS; Leon F; Lamb KM; Plemper RK; Wright ER
The Unstructured Paramyxovirus Nucleocapsid Protein Tail Domain Modulates Viral Pathogenesis through Regulation of Transcriptase Activity.
J Virol Volume: 92
04/15/2018 Authors: Thakkar VD; Cox RM; Sawatsky B; da Fontoura Budaszewski R; Sourimant J; Wabbel K; Makhsous N; Greninger AL; von Messling V; Plemper RK
Structures of the prefusion form of measles virus fusion protein in complex with inhibitors.
Proc Natl Acad Sci U S A Volume: 115 Page(s): 2496 - 2501
03/06/2018 Authors: Hashiguchi T; Fukuda Y; Matsuoka R; Kuroda D; Kubota M; Shirogane Y; Watanabe S; Tsumoto K; Kohda D; Plemper RK
Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.
J Virol Volume: 91
12/01/2017 Authors: Ha MN; Delpeut S; Noyce RS; Sisson G; Black KM; Lin L-T; Bilimoria D; Plemper RK; Priv GG; Richardson CD
Structure and organization of paramyxovirus particles.
Curr Opin Virol Volume: 24 Page(s): 105 - 114
06/01/2017 Authors: Cox RM; Plemper RK
Polymerases of paramyxoviruses and pneumoviruses.
Virus Res Volume: 234 Page(s): 87 - 102
04/15/2017 Authors: Fearns R; Plemper RK
Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex.
J Med Chem Volume: 60 Page(s): 2305 - 2325
03/23/2017 Authors: Jimnez-Somarribas A; Mao S; Yoon J-J; Weisshaar M; Cox RM; Marengo JR; Mitchell DG; Morehouse ZP; Yan D; Solis I
The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient.
Sci Adv Volume: 3 Page(s): e1602350
02/01/2017 Authors: Cox RM; Krumm SA; Thakkar VD; Sohn M; Plemper RK
Releasing the Genomic RNA Sequestered in the Mumps Virus Nucleocapsid.
J Virol Volume: 90 Page(s): 10113 - 10119
11/15/2016 Authors: Severin C; Terrell JR; Zengel JR; Cox R; Plemper RK; He B; Luo M
Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex.
Viruses Volume: 8
09/10/2016 Authors: Sourimant J; Plemper RK
Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening.
J Virol Volume: 90 Page(s): 7368 - 7387
08/15/2016 Authors: Weisshaar M; Cox R; Morehouse Z; Kyasa SK; Yan D; Oberacker P; Mao S; Golden JE; Lowen AC; Natchus MG
EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression.
PLoS Pathog Volume: 12 Page(s): e1005622
05/01/2016 Authors: Currier MG; Lee S; Stobart CC; Hotard AL; Villenave R; Meng J; Pretto CD; Shields MD; Nguyen MT; Todd SO
Structure-guided design of small-molecule therapeutics against RSV disease.
Expert Opin Drug Discov Volume: 11 Page(s): 543 - 556
01/01/2016 Authors: Cox R; Plemper RK
Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens.
Biochemistry Volume: 54 Page(s): 5589 - 5604
09/15/2015 Authors: Yan D; Weisshaar M; Lamb K; Chung HK; Lin MZ; Plemper RK
Tunable and reversible drug control of protein production via a self-excising degron.
Nat Chem Biol Volume: 11 Page(s): 713 - 720
09/01/2015 Authors: Chung HK; Jacobs CL; Huo Y; Yang J; Krumm SA; Plemper RK; Tsien RY; Lin MZ
Blocking Respiratory Syncytial Virus Entry: A Story with Twists.
DNA Cell Biol Volume: 34 Page(s): 505 - 510
08/01/2015 Authors: Weisshaar M; Cox R; Plemper RK
Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process.
PLoS Pathog Volume: 11 Page(s): e1004880
05/01/2015 Authors: Ader-Ebert N; Khosravi M; Herren M; Avila M; Alves L; Bringolf F; rvell C; Langedijk JP; Zurbriggen A; Plemper RK
Recombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease.
Virology Volume: 476 Page(s): 217 - 225
02/01/2015 Authors: Lee Y-N; Suk Hwang H; Kim M-C; Lee Y-T; Cho M-K; Kwon Y-M; Seok Lee J; Plemper RK; Kang S-M
Measles virus glycoprotein complexes preassemble intracellularly and relax during transport to the cell surface in preparation for fusion.
J Virol Volume: 89 Page(s): 1230 - 1241
01/15/2015 Authors: Brindley MA; Chaudhury S; Plemper RK
Canine distemper virus envelope protein interactions modulated by hydrophobic residues in the fusion protein globular head.
J Virol Volume: 89 Page(s): 1445 - 1451
01/15/2015 Authors: Avila M; Khosravi M; Alves L; Ader-Ebert N; Bringolf F; Zurbriggen A; Plemper RK; Plattet P
The paramyxovirus polymerase complex as a target for next-generation anti-paramyxovirus therapeutics.
Front Microbiol Volume: 6 Page(s): 459
01/01/2015 Authors: Cox R; Plemper RK
Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.
J Virol Volume: 89 Page(s): 512 - 522
01/01/2015 Authors: Hotard AL; Lee S; Currier MG; Crowe JE; Sakamoto K; Newcomb DC; Peebles RS; Plemper RK; Moore ML
Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity.
J Med Chem Volume: 57 Page(s): 10314 - 10328
12/26/2014 Authors: Matharu DS; Flaherty DP; Simpson DS; Schroeder CE; Chung D; Yan D; Noah JW; Jonsson CB; White EL; Aub J
Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain.
Proc Natl Acad Sci U S A Volume: 111 Page(s): E3795 - E3804
09/09/2014 Authors: Brindley MA; Plattet P; Plemper RK
Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors.
Proc Natl Acad Sci U S A Volume: 111 Page(s): E3441 - E3449
08/19/2014 Authors: Yan D; Lee S; Thakkar VD; Luo M; Moore ML; Plemper RK
An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.
Sci Transl Med Volume: 6 Page(s): 232ra52
04/16/2014 Authors: Krumm SA; Yan D; Hovingh ES; Evers TJ; Enkirch T; Reddy GP; Sun A; Saindane MT; Arrendale RF; Painter G
Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virus.
J Virol Volume: 88 Page(s): 2951 - 2966
03/01/2014 Authors: Avila M; Alves L; Khosravi M; Ader-Ebert N; Origgi F; Schneider-Schaulies J; Zurbriggen A; Plemper RK; Plattet P
Synergizing vaccinations with therapeutics for measles eradication.
Expert Opin Drug Discov Volume: 9 Page(s): 201 - 214
02/01/2014 Authors: Plemper RK; Hammond AL
Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications.
Microsc Microanal Volume: 20 Page(s): 164 - 174
02/01/2014 Authors: Kiss G; Chen X; Brindley MA; Campbell P; Afonso CL; Ke Z; Holl JM; Guerrero-Ferreira RC; Byrd-Leotis LA; Steel J
A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion.
J Virol Volume: 87 Page(s): 11693 - 11703
11/01/2013 Authors: Brindley MA; Suter R; Schestak I; Kiss G; Wright ER; Plemper RK
The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity.
J Biol Chem Volume: 288 Page(s): 29943 - 29953
10/11/2013 Authors: Krumm SA; Takeda M; Plemper RK
Dual myxovirus screen identifies a small-molecule agonist of the host antiviral response.
J Virol Volume: 87 Page(s): 11076 - 11087
10/01/2013 Authors: Yan D; Krumm SA; Sun A; Steinhauer DA; Luo M; Moore ML; Plemper RK
The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection.
J Virol Volume: 87 Page(s): 10070 - 10082
09/01/2013 Authors: Stokes KL; Currier MG; Sakamoto K; Lee S; Collins PL; Plemper RK; Moore ML
Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy.
ACS Med Chem Lett Volume: 4 Page(s): 762 - 767
08/08/2013 Authors: Moore TW; Sana K; Yan D; Krumm SA; Thepchatri P; Snyder JP; Marengo J; Arrendale RF; Prussia AJ; Natchus MG
Envelope protein dynamics in paramyxovirus entry.
mBio Volume: 4
07/02/2013 Authors: Plattet P; Plemper RK
The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope.
J Virol Volume: 87 Page(s): 3583 - 3586
03/01/2013 Authors: Tahara M; Ohno S; Sakai K; Ito Y; Fukuhara H; Komase K; Brindley MA; Rota PA; Plemper RK; Maenaka K
Asymmetric synthesis of host-directed inhibitors of myxoviruses.
Beilstein J Org Chem Volume: 9 Page(s): 197 - 203
01/01/2013 Authors: Moore TW; Sana K; Yan D; Thepchatri P; Ndungu JM; Saindane MT; Lockwood MA; Natchus MG; Liotta DC; Plemper RK
Mechanism for active membrane fusion triggering by morbillivirus attachment protein.
J Virol Volume: 87 Page(s): 314 - 326
01/01/2013 Authors: Ader N; Brindley M; Avila M; rvell C; Horvat B; Hiltensperger G; Schneider-Schaulies J; Vandevelde M; Zurbriggen A; Plemper RK
Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein.
J Virol Volume: 87 Page(s): 666 - 675
01/01/2013 Authors: Tahara M; Ito Y; Brindley MA; Ma X; He J; Xu S; Fukuhara H; Sakai K; Komase K; Rota PA
A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis.
Virology Volume: 434 Page(s): 129 - 136
12/05/2012 Authors: Hotard AL; Shaikh FY; Lee S; Yan D; Teng MN; Plemper RK; Crowe JE; Moore ML
Triggering the measles virus membrane fusion machinery.
Proc Natl Acad Sci U S A Volume: 109 Page(s): E3018 - E3027
10/30/2012 Authors: Brindley MA; Takeda M; Plattet P; Plemper RK
Structure of the primed paramyxovirus fusion protein.
Proc Natl Acad Sci U S A Volume: 109 Page(s): 16404 - 16405
10/09/2012 Authors: Steinhauer DA; Plemper RK
Structural rearrangements of the central region of the morbillivirus attachment protein stalk domain trigger F protein refolding for membrane fusion.
J Biol Chem Volume: 287 Page(s): 16324 - 16334
05/11/2012 Authors: Ader N; Brindley MA; Avila M; Origgi FC; Langedijk JPM; rvell C; Vandevelde M; Zurbriggen A; Plemper RK; Plattet P
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.
J Med Chem Volume: 55 Page(s): 4220 - 4230
05/10/2012 Authors: Ndungu JM; Krumm SA; Yan D; Arrendale RF; Reddy GP; Evers T; Howard R; Natchus MG; Saindane MT; Liotta DC
Independent structural domains in paramyxovirus polymerase protein.
J Biol Chem Volume: 287 Page(s): 6878 - 6891
02/24/2012 Authors: Dochow M; Krumm SA; Crowe JE; Moore ML; Plemper RK
Host-directed Inhibitors of Myxoviruses: Synthesis and in vitro Biochemical Evaluation.
ACS Med Chem Lett Volume: 2 Page(s): 798 - 803
08/23/2011 Authors: Sun A; Ndungu JM; Krumm SA; Yoon J-J; Thepchatri P; Natchus M; Plemper RK; Snyder JP
Cell entry of enveloped viruses.
Curr Opin Virol Volume: 1 Page(s): 92 - 100
08/01/2011 Authors: Plemper RK
Structural and mechanistic studies of measles virus illuminate paramyxovirus entry.
PLoS Pathog Volume: 7 Page(s): e1002058
06/01/2011 Authors: Plemper RK; Brindley MA; Iorio RM
Systematic approaches towards the development of host-directed antiviral therapeutics.
Int J Mol Sci Volume: 12 Page(s): 4027 - 4052
01/01/2011 Authors: Prussia A; Thepchatri P; Snyder JP; Plemper RK
Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.
PLoS One Volume: 6 Page(s): e20069
01/01/2011 Authors: Krumm SA; Ndungu JM; Yoon J-J; Dochow M; Sun A; Natchus M; Snyder JP; Plemper RK
Blue native PAGE and biomolecular complementation reveal a tetrameric or higher-order oligomer organization of the physiological measles virus attachment protein H.
J Virol Volume: 84 Page(s): 12174 - 12184
12/01/2010 Authors: Brindley MA; Plemper RK
Synthesis and antiviral activity of a second generation of measles virus RNA-dependent RNA polymerase activity inhibitors
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 240
08/22/2010 Authors: Ndungu JM; Krumm SA; Sun A; Plemper RK; Snyder JP
Probing the spatial organization of measles virus fusion complexes.
J Virol Volume: 83 Page(s): 10480 - 10493
10/01/2009 Authors: Paal T; Brindley MA; St Clair C; Prussia A; Gaus D; Krumm SA; Snyder JP; Plemper RK
Target analysis of the experimental measles therapeutic AS-136A.
Antimicrob Agents Chemother Volume: 53 Page(s): 3860 - 3870
09/01/2009 Authors: Yoon J-J; Krumm SA; Ndungu JM; Hoffman V; Bankamp B; Rota PA; Sun A; Snyder JP; Plemper RK
Measles control--can measles virus inhibitors make a difference?
Curr Opin Investig Drugs Volume: 10 Page(s): 811 - 820
08/01/2009 Authors: Plemper RK; Snyder JP
Cancer and virus leads by HTS, chemical design and SEA data mining.
Curr Top Med Chem Volume: 9 Page(s): 1159 - 1171
01/01/2009 Authors: Thepchatri P; Min J; Ganesh T; Du Y; Lewis I; Kurtkaya S; Prussia A; Li L; Sneed B; Plemper RK
Measles virus entry inhibitors: a structural proposal for mechanism of action and the development of resistance.
Biochemistry Volume: 47 Page(s): 13573 - 13583
12/23/2008 Authors: Prussia AJ; Plemper RK; Snyder JP
High-throughput screening-based identification of paramyxovirus inhibitors.
J Biomol Screen Volume: 13 Page(s): 591 - 608
08/01/2008 Authors: Yoon J-J; Chawla D; Paal T; Ndungu M; Du Y; Kurtkaya S; Sun A; Snyder JP; Plemper RK
Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex.
J Med Chem Volume: 51 Page(s): 3731 - 3741
07/10/2008 Authors: Sun A; Yoon J-J; Yin Y; Prussia A; Yang Y; Min J; Plemper RK; Snyder JP
Functional interaction between paramyxovirus fusion and attachment proteins.
J Biol Chem Volume: 283 Page(s): 16561 - 16572
06/13/2008 Authors: Lee JK; Prussia A; Paal T; White LK; Snyder JP; Plemper RK
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation.
Bioorg Med Chem Lett Volume: 17 Page(s): 5199 - 5203
09/15/2007 Authors: Sun A; Chandrakumar N; Yoon J-J; Plemper RK; Snyder JP
Reversible inhibition of the fusion activity of measles virus F protein by an engineered intersubunit disulfide bridge.
J Virol Volume: 81 Page(s): 8821 - 8826
08/01/2007 Authors: Lee JK; Prussia A; Snyder JP; Plemper RK
Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity.
Antimicrob Agents Chemother Volume: 51 Page(s): 2293 - 2303
07/01/2007 Authors: White LK; Yoon J-J; Lee JK; Sun A; Du Y; Fu H; Snyder JP; Plemper RK
Nonpeptide inhibitors of measles virus entry.
J Med Chem Volume: 49 Page(s): 5080 - 5092
08/24/2006 Authors: Sun A; Prussia A; Zhan W; Murray EE; Doyle J; Cheng L-T; Yoon J-J; Radchenko EV; Palyulin VA; Compans RW
Rational design of measles virus entry inhibitors and mechanisms of viral resistance
Volume: 231
03/26/2006 Authors: Prussia AJ; Plemper RK; Sun A; Doyle J; White LK; Cheng L-T; Liotta DC; Snyder JP; Compans RW
Two domains that control prefusion stability and transport competence of the measles virus fusion protein.
J Virol Volume: 80 Page(s): 1524 - 1536
02/01/2006 Authors: Doyle J; Prussia A; White LK; Sun A; Liotta DC; Snyder JP; Compans RW; Plemper RK
Design of a small-molecule entry inhibitor with activity against primary measles virus strains.
Antimicrob Agents Chemother Volume: 49 Page(s): 3755 - 3761
09/01/2005 Authors: Plemper RK; Doyle J; Sun A; Prussia A; Cheng L-T; Rota PA; Liotta DC; Snyder JP; Compans RW
Atypical fusion peptide of Nelson Bay virus fusion-associated small transmembrane protein.
J Virol Volume: 79 Page(s): 1853 - 1860
02/01/2005 Authors: Cheng LT; Plemper RK; Compans RW
Inhibition of the measles virus cell entry: Fusion blockade.
Volume: 228 Page(s): U968 - U968
08/22/2004 Authors: Sun AM; Plemper RK; Erlandson KJ; Lakdawala A; Prussia A; Akisener E; Yalcin I; Yildliz I; Temiz-Arpaci O; Tekiner B
A target site for template-based design of measles virus entry inhibitors.
Proc Natl Acad Sci U S A Volume: 101 Page(s): 5628 - 5633
04/13/2004 Authors: Plemper RK; Erlandson KJ; Lakdawala AS; Sun A; Prussia A; Boonsombat J; Aki-Sener E; Yalcin I; Yildiz I; Temiz-Arpaci O
Structural features of paramyxovirus F protein required for fusion initiation.
Biochemistry Volume: 42 Page(s): 6645 - 6655
06/10/2003 Authors: Plemper RK; Lakdawala AS; Gernert KM; Snyder JP; Compans RW
Mutations in the putative HR-C region of the measles virus F2 glycoprotein modulate syncytium formation.
J Virol Volume: 77 Page(s): 4181 - 4190
04/01/2003 Authors: Plemper RK; Compans RW
Strength of envelope protein interaction modulates cytopathicity of measles virus.
J Virol Volume: 76 Page(s): 5051 - 5061
05/01/2002 Authors: Plemper RK; Hammond AL; Gerlier D; Fielding AK; Cattaneo R
Protein degradation in human disease.
Prog Mol Subcell Biol Volume: 29 Page(s): 61 - 84
01/01/2002 Authors: Plemper RK; Hammond AL
Measles virus envelope glycoproteins hetero-oligomerize in the endoplasmic reticulum.
J Biol Chem Volume: 276 Page(s): 44239 - 44246
11/23/2001 Authors: Plemper RK; Hammond AL; Cattaneo R
Regulation of caveolin-1 phosphorylation following PDGF stimulation in human vascular smooth muscle cells
CIRCULATION Volume: 104 Page(s): 224 - 224
10/23/2001 Authors: Peterson TE; Plemper RK; Kleppe LS; Mueske CS; Simari RD
Strength of interaction between measles virus haemagglutinin and fusion protein influences virus growth and cytopathicity
GENE THERAPY Volume: 8 Page(s): S10 - S10
10/01/2001 Authors: Plemper RK; Hammond AL; Cattaneo R
Comparing the rate of cell entry of wild-type and vaccine strains of measles virus
GENE THERAPY Volume: 8 Page(s): S9 - S9
10/01/2001 Authors: Hammond AL; Plemper RK; Cattaneo R
Single-chain antibody displayed on a recombinant measles virus confers entry through the tumor-associated carcinoembryonic antigen.
J Virol Volume: 75 Page(s): 2087 - 2096
03/01/2001 Authors: Hammond AL; Plemper RK; Zhang J; Schneider U; Russell SJ; Cattaneo R
Characterization of a region of the measles virus hemagglutinin sufficient for its dimerization.
J Virol Volume: 74 Page(s): 6485 - 6493
07/01/2000 Authors: Plemper RK; Hammond AL; Cattaneo R
Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.
J Cell Sci Volume: 112 ( Pt 22) Page(s): 4123 - 4134
11/01/1999 Authors: Plemper RK; Bordallo J; Deak PM; Taxis C; Hitt R; Wolf DH
Retrograde protein translocation: ERADication of secretory proteins in health and disease.
Trends Biochem Sci Volume: 24 Page(s): 266 - 270
07/01/1999 Authors: Plemper RK; Wolf DH
Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome.
Mol Biol Rep Volume: 26 Page(s): 125 - 130
04/01/1999 Authors: Plemper RK; Wolf DH
Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species.
FEBS Lett Volume: 443 Page(s): 241 - 245
01/29/1999 Authors: Plemper RK; Deak PM; Otto RT; Wolf DH
Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.
J Biol Chem Volume: 273 Page(s): 32848 - 32856
12/04/1998 Authors: Plemper RK; Egner R; Kuchler K; Wolf DH
The medial-Golgi ion pump Pmr1 supplies the yeast secretory pathway with Ca2+ and Mn2+ required for glycosylation, sorting, and endoplasmic reticulum-associated protein degradation.
Mol Biol Cell Volume: 9 Page(s): 1149 - 1162
05/01/1998 Authors: Drr G; Strayle J; Plemper R; Elbs S; Klee SK; Catty P; Wolf DH; Rudolph HK
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.
Mol Biol Cell Volume: 9 Page(s): 209 - 222
01/01/1998 Authors: Bordallo J; Plemper RK; Finger A; Wolf DH
Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.
Nature Volume: 388 Page(s): 891 - 895
08/28/1997 Authors: Plemper RK; Bhmler S; Bordallo J; Sommer T; Wolf DH

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Richard Plemper

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