Renhao Li

Department of Pediatrics
Adjunct Professor

Aflac Cancer & Blood Disorders Center
Pediatrics
2015 Uppergate Drive NE, Room 440

Academic Appointment

Andrew Glaub Research Chair, Pediatrics, Emory University School of Medicine
Professor of Pediatrics (Tenured), Pediatrics, Emory University

Education

Degrees

PhD from University of Minnesota- Twin Cities
BS from Nanjing University

Research

Focus

My research program has focused on the structure and function studies of transmembrane receptors on the surface of blood cells, and we seek to develop novel reagents and diagnostic tools to treat blood diseases.

Publications

The sweet business of VWF clearance.
Blood Volume: 145 Page(s): 2680 - 2681
06/05/2025 Authors: Li R; Sidonio RF
International opinion survey on nomenclature for platelet-type von Willebrand disease: communication from the SSC of the ISTH.
J Thromb Haemost
05/04/2025 Authors: Othman M; Lavin M; Li R; Elsebaie A; Baker R; Lordkipanidz M; Freson K; Gresele P; EXPERT collaborators
Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS.
Blood Adv Volume: 9 Page(s): 1763 - 1771
04/22/2025 Authors: Bonnez Q; Legan ER; Pareyn I; Boudry F; Anckaert J; Tersteeg C; De Meyer SF; Li R; Vanhoorelbeke K
Autoantibodies immuno-mechanically modulate platelet contractile force and bleeding risk.
Nat Commun Volume: 15 Page(s): 10201
11/25/2024 Authors: Oshinowo O; Copeland R; Patel A; Shaver N; Fay ME; Jeltuhin R; Xiang Y; Caruso C; Otumala AE; Hernandez S
Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy.
J Thromb Haemost Volume: 22 Page(s): 3249 - 3265
11/01/2024 Authors: Shen C; Mackeigan DT; Shoara AA; Bhoria P; Zhu G; Karakas D; Ma W; Chen ZY; Xu R; Slavkovic S
Nanobody activator improves sensitivity of the von Willebrand factor activity assay to multimer size.
J Thromb Haemost Volume: 22 Page(s): 2052 - 2058
07/01/2024 Authors: Liang Q; Parker ET; Dean G; Karpen MS; Wu Y; Wang X; Di Paola J; Maier CL; Meeks SL; Lollar P
Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module.
Blood Volume: 143 Page(s): 1992 - 2004
05/09/2024 Authors: Arce NA; Markham-Lee Z; Liang Q; Najmudin S; Legan ER; Dean G; Su AJ; Wilson MS; Sidonio RF; Lollar P
Platelet size matters.
Blood Volume: 143 Page(s): 298 - 300
01/25/2024 Authors: Li R
Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming -propeller.
Nat Commun Volume: 15 Page(s): 155
01/02/2024 Authors: Saccuzzo EG; Mebrat MD; Scelsi HF; Kim M; Ma MT; Su X; Hill SE; Rheaume E; Li R; Torres MP
Molecular mechanocytometry using tension-activated cell tagging.
Nat Methods Volume: 20 Page(s): 1666 - 1671
11/01/2023 Authors: Ma R; Rashid SA; Velusamy A; Deal BR; Chen W; Petrich B; Li R; Salaita K
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand.
Nat Biomed Eng Volume: 7 Page(s): 1404 - 1418
11/01/2023 Authors: Duan Y; Szlam F; Hu Y; Chen W; Li R; Ke Y; Sniecinski R; Salaita K
A wild boar cathelicidin peptide derivative inhibits severe acute respiratory syndrome coronavirus-2 and its drifted variants.
Sci Rep Volume: 13 Page(s): 14650
09/05/2023 Authors: von Beck T; Navarrete K; Arce NA; Gao M; Dale GA; Davis-Gardner ME; Floyd K; Mena Hernandez L; Mullick N; Vanderheiden A
Specific O-glycans in the mechanosensory domain of glycoprotein Ib are important for its stability and function.
Haematologica Volume: 108 Page(s): 2526 - 2530
09/01/2023 Authors: Wang Y; Li R
Another layer of complexity in ectodomain shedding of platelet glycoprotein Ib.
J Thromb Haemost Volume: 21 Page(s): 2051 - 2053
08/01/2023 Authors: Li R
A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions.
Transl Res Volume: 254 Page(s): 68 - 76
04/01/2023 Authors: Huang W; Li R; Zhang J; Cheng Y; Ramakrishnan DP; Silverstein RL
Platelet glycoprotein V spatio-temporally controls fibrin formation.
Nat Cardiovasc Res Volume: 2 Page(s): 368 - 382
04/01/2023 Authors: Beck S; ftering P; Li R; Hemmen K; Nagy M; Wang Y; Zarpellon A; Schuhmann MK; Stoll G; Ruggeri ZM
Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain.
Blood Volume: 141 Page(s): 1221 - 1232
03/09/2023 Authors: Legan ER; Liu Y; Arce NA; Parker ET; Lollar P; Zhang XF; Li R
Autoinhibitory module underlies species difference in shear activation of von Willebrand factor.
J Thromb Haemost Volume: 20 Page(s): 2686 - 2696
11/01/2022 Authors: Arce NA; Liu Y; Chen W; Zhang XF; Li R
Recent advances on GPIb-IX-V complex.
Platelets Volume: 33 Page(s): 809 - 810
08/18/2022 Authors: Li R
Fast clearance of platelets in a commonly used mouse model for GPIb is impeded by an anti-GPIb antibody derivative.
J Thromb Haemost Volume: 20 Page(s): 1451 - 1463
06/01/2022 Authors: Chen W; Wilson MS; Wang Y; Bergmeier W; Lanza F; Li R
Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies.
J Thromb Haemost Volume: 20 Page(s): 574 - 588
03/01/2022 Authors: Ito J; Baldwin WH; Cox C; Healey JF; Parker ET; Legan ER; Li R; Gill S; Batsuli G
Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module.
J Thromb Haemost Volume: 20 Page(s): 196 - 207
01/01/2022 Authors: Voos KM; Cao W; Arce NA; Legan ER; Wang Y; Shajahan A; Azadi P; Lollar P; Zhang XF; Li R
Author Correction: Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope.
Nat Commun Volume: 12 Page(s): 5600
09/16/2021 Authors: Blanchard A; Combs JD; Brockman JM; Kellner AV; Glazier R; Su H; Bender RL; Bazrafshan AS; Chen W; Quach ME
DNA-Based Microparticle Tension Sensors (TS) for Measuring Cell Mechanics in Non-planar Geometries and for High-Throughput Quantification.
Angew Chem Int Ed Engl Volume: 60 Page(s): 18044 - 18050
08/09/2021 Authors: Hu Y; Ma VP-Y; Ma R; Chen W; Duan Y; Glazier R; Petrich BG; Li R; Salaita K
Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope.
Nat Commun Volume: 12 Page(s): 4693
08/03/2021 Authors: Blanchard A; Combs JD; Brockman JM; Kellner AV; Glazier R; Su H; Bender RL; Bazrafshan AS; Chen W; Quach ME
Differential regulation of the platelet GPIb-IX complex by anti-GPIb antibodies.
J Thromb Haemost Volume: 19 Page(s): 2044 - 2055
08/01/2021 Authors: Quach ME; Chen W; Wang Y; Deckmyn H; Lanza F; Nieswandt B; Li R
Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module.
Nat Commun Volume: 12 Page(s): 2360
04/21/2021 Authors: Arce NA; Cao W; Brown AK; Legan ER; Wilson MS; Xu E-R; Berndt MC; Emsley J; Zhang XF; Li R
Desialylation of O-glycans on glycoprotein Ib drives receptor signaling and platelet clearance.
Haematologica Volume: 106 Page(s): 220 - 229
01/01/2021 Authors: Wang Y; Chen W; Zhang W; Lee-Sundlov MM; Casari C; Berndt MC; Lanza F; Bergmeier W; Hoffmeister KM; Zhang XF
Structure-function of platelet glycoprotein Ib-IX.
J Thromb Haemost Volume: 18 Page(s): 3131 - 3141
12/01/2020 Authors: Quach ME; Li R
Live-cell super-resolved PAINT imaging of piconewton cellular traction forces.
Nat Methods Volume: 17 Page(s): 1018 - 1024
10/01/2020 Authors: Brockman JM; Su H; Blanchard AT; Duan Y; Meyer T; Quach ME; Glazier R; Bazrafshan A; Bender RL; Kellner AV
High prevalence of the natural Asn89Asp mutation in the GP1BB gene associated with Bernard-Soulier syndrome in French patients from the genetic isolate of Reunion Island.
Br J Haematol Volume: 189 Page(s): e67 - e71
05/01/2020 Authors: Fiore M; De Thor C; Randrianaivo-Ranjatoelina H; Baas M-J; Jacquemont M-L; Dreyfus M; Lavenu-Bombled C; Li R; Gachet C; Dupuis A
Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ib: implications for Bernard-Soulier syndrome.
J Thromb Haemost Volume: 18 Page(s): 510 - 517
02/01/2020 Authors: Tao Y; Gan C; Zhang X; Liu L; Zakas PM; Doering CB; Mo X; Li R
Characterization of Recombinant beta 2GPI Using Hydrogen-Deuterium Exchange and X-Ray Crystallography
Volume: 134
11/13/2019 Authors: Alluri RK; Arce N; Klenotic P; Su CC; Kundu S; Yu E; Li R; McCrae KR
Short-Acting Anti-VWF (von Willebrand Factor) Aptamer Improves the Recovery, Survival, and Hemostatic Functions of Refrigerated Platelets.
Arterioscler Thromb Vasc Biol Volume: 39 Page(s): 2028 - 2037
10/01/2019 Authors: Chen W; Voos KM; Josephson CD; Li R
A novel missense mutation in a leucine-rich repeat of GPIb in a Bernard-Soulier variant reduces shear-dependent adherence on von Willebrand factor.
Br J Haematol Volume: 186 Page(s): e184 - e187
09/01/2019 Authors: Proulle V; Strassel C; Perrault C; Baas M-J; Moog S; Mangin P; Nurden P; Nurden A; Adam F; Bryckaert M
Gone With the Vane.
Arterioscler Thromb Vasc Biol Volume: 39 Page(s): 1702 - 1704
09/01/2019 Authors: Legan ER; Li R
The secret afterlife of platelets.
Haematologica Volume: 104 Page(s): 1699 - 1701
09/01/2019 Authors: Arce NA; Li R
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry.
J Vis Exp
06/05/2019 Authors: Quach ME; Syed AK; Li R
FAM-tastic phospho-regulation of von Willebrand factor activity.
J Thromb Haemost Volume: 17 Page(s): 863 - 865
06/01/2019 Authors: Legan ER; Li R
Force-Regulated Refolding of the Mechanosensory Domain in the Platelet Glycoprotein Ib-IX Complex.
Biophys J Volume: 116 Page(s): 1960 - 1969
05/21/2019 Authors: Zhang XF; Zhang W; Quach ME; Deng W; Li R
Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J Thromb Haemost Volume: 17 Page(s): 759 - 770
05/01/2019 Authors: Li C; Voos KM; Pathak M; Hall G; McCrae KR; Dreveny I; Li R; Emsley J
Force-Induced Unfolding of a Mechanosensory Domain in Platelet Glycoprotein (Gp)Ib-IX under Solution and Adherent Conditions
Volume: 116 Page(s): 376A - 376A
02/15/2019 Authors: Quach ME; Combs D; Salaita K; Li R
Novel Antibodies Against Glycoprotein Iba Inhibit Pulmonary Metastasis By Affecting Vwf-Gpiba Interaction
Volume: 132
11/29/2018 Authors: Qi Y; Chen W; Xu K; Wu F; Fan X; Ren S; Liu J; Deng W; Zhang J; Li R
A Novel Anti-Glycoprotein (GP) Iba-Targeting Chimeric Fibrinolytic Agent Demonstrates In Vivo Efficacy Against Human Platelet-Enriched Thrombi in Mice
Volume: 132
11/29/2018 Authors: Lyde R; Ahn H; Hayes V; Zaistev S; Lin S-W; Ruggeri ZM; Li R; Muzykantov V; Cines DB; Poncz M
Short-Acting Anti-VWF Aptamer Improves the Recovery and Survival, and Hemostatic Functions of Refrigerated Platelets
Volume: 132
11/29/2018 Authors: Chen W; Voos KM; Josephson CD; Li R
Delimiting the autoinhibitory module of von Willebrand factor.
J Thromb Haemost Volume: 16 Page(s): 2097 - 2105
10/01/2018 Authors: Deng W; Voos KM; Colucci JK; Legan ER; Ortlund EA; Lollar P; Li R
Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects.
Blood Adv Volume: 2 Page(s): 2320 - 2331
09/25/2018 Authors: Baaten CCFMJ; Swieringa F; Misztal T; Mastenbroek TG; Feijge MAH; Bock PE; Donners MMPC; Collins PW; Li R; van der Meijden PEJ
Novel antibodies against GPIb inhibit pulmonary metastasis by affecting vWF-GPIb interaction.
J Hematol Oncol Volume: 11 Page(s): 117
09/17/2018 Authors: Qi Y; Chen W; Liang X; Xu K; Gu X; Wu F; Fan X; Ren S; Liu J; Zhang J
A new redox switch regulating von Willebrand factor activity.
J Thromb Haemost Volume: 16 Page(s): 1257 - 1258
07/01/2018 Authors: Deng W; Voos KM; Li R
Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI.
J Biol Chem Volume: 293 Page(s): 8521 - 8529
06/01/2018 Authors: Cook AA; Deng W; Ren J; Li R; Sondek J; Bergmeier W
Mechanisms of platelet clearance and translation to improve platelet storage.
Blood Volume: 131 Page(s): 1512 - 1521
04/05/2018 Authors: Quach ME; Chen W; Li R
A General Method for Predicting Amino Acid Residues Experiencing Hydrogen Exchange.
IEEE EMBS Int Conf Biomed Health Inform Volume: 2018 Page(s): 341 - 344
03/01/2018 Authors: Wang B; Perez-Rathke A; Li R; Liang J
Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.
Blood Volume: 131 Page(s): 787 - 796
02/15/2018 Authors: Quach ME; Dragovich MA; Chen W; Syed AK; Cao W; Liang X; Deng W; De Meyer SF; Zhu G; Peng J
Refrigeration-Induced Binding of von Willebrand Factor Facilitates Fast Clearance of Refrigerated Platelets.
Arterioscler Thromb Vasc Biol Volume: 37 Page(s): 2271 - 2279
12/01/2017 Authors: Chen W; Druzak SA; Wang Y; Josephson CD; Hoffmeister KM; Ware J; Li R
Twins actin' differently.
Blood Volume: 130 Page(s): 1688 - 1689
10/12/2017 Authors: Li R
A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor.
J Thromb Haemost Volume: 15 Page(s): 1867 - 1877
09/01/2017 Authors: Deng W; Wang Y; Druzak SA; Healey JF; Syed AK; Lollar P; Li R
A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malm/New York" von Willebrand disease.
Thromb Haemost Volume: 116 Page(s): 1070 - 1078
11/30/2016 Authors: Lavenu-Bombled C; Guitton C; Dupuis A; Baas M-J; Desconclois C; Dreyfus M; Li R; Caron C; Gachet C; Fressinaud E
High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors.
Blood Volume: 128 Page(s): 2055 - 2067
10/20/2016 Authors: Batsuli G; Deng W; Healey JF; Parker ET; Baldwin WH; Cox C; Nguyen B; Kahle J; Knigs C; Li R
Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.
Nat Commun Volume: 7 Page(s): 12863
09/27/2016 Authors: Deng W; Xu Y; Chen W; Paul DS; Syed AK; Dragovich MA; Liang X; Zakas P; Berndt MC; Di Paola J
Glycans and the platelet life cycle.
Platelets Volume: 27 Page(s): 505 - 511
09/01/2016 Authors: Li R; Hoffmeister KM; Falet H
Inhibiting GPIb Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage.
Arterioscler Thromb Vasc Biol Volume: 36 Page(s): 1821 - 1828
09/01/2016 Authors: Chen W; Liang X; Syed AK; Jessup P; Church WR; Ware J; Josephson CD; Li R
INHIBITING GPIB alpha SHEDDING PRESERVES POST-TRANSFUSION RECOVERY AND HEMOSTATIC FUNCTION OF PLATELETS AFTER PROLONGED STORAGE
AMERICAN JOURNAL OF HEMATOLOGY Volume: 91 Page(s): E398 - E398
09/01/2016 Authors: Chen W; Liang X; Syed AK; Jessup P; Church WR; Ware J; Josephson CD; Li R
Structural basis for the specific inhibition of glycoprotein Ib shedding by an inhibitory antibody.
Sci Rep Volume: 6 Page(s): 24789
04/22/2016 Authors: Tao Y; Zhang X; Liang X; Zang J; Mo X; Li R
Mechanism and Functions of Platelet Mechanosensing
Volume: 110 Page(s): 31A - 31A
02/16/2016 Authors: Li R
Dimerization of glycoprotein Ib is not sufficient to induce platelet clearance.
J Thromb Haemost Volume: 14 Page(s): 381 - 386
02/01/2016 Authors: Liang X; Syed AK; Russell SR; Ware J; Li R
Evaluating interactions between bacterial SRR adhesins and human platelet glycoprotein GPIba by glycoproteomics approaches
Volume: 25 Page(s): 1247 - 1247
11/01/2015 Authors: Deng L; Bensing B; Yang W; Li R; Ware J; Varki A; Sullam P; Zhang H
Expanding the binding model of DITP.
Blood Volume: 126 Page(s): 2080 - 2081
10/29/2015 Authors: Li R
2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.
Transfusion Volume: 55 Page(s): 2282 - 2290
09/01/2015 Authors: Spitalnik SL; Triulzi D; Devine DV; Dzik WH; Eder AF; Gernsheimer T; Josephson CD; Kor DJ; Luban NLC; Roubinian NH
Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.
Blood Volume: 126 Page(s): 817 - 824
08/06/2015 Authors: Ciciliano JC; Sakurai Y; Myers DR; Fay ME; Hechler B; Meeks S; Li R; Dixon JB; Lyon LA; Gachet C
Juxtamembrane contribution to transmembrane signaling.
Biopolymers Volume: 104 Page(s): 317 - 322
07/01/2015 Authors: Deng W; Li R
Specific inhibition of GPIb alpha shedding improves post-transfusion recovery and adhesive function of outdated human apheresis platelets
Volume: 13 Page(s): 18 - 18
06/01/2015 Authors: Liang X; Tao Y; Syed AK; Jessup P; Church W; Josephson CD; Mo X; Li R
Shear-induced GPIb-IX signaling via unfolding of its juxtamembrane mechanosensory domain
Volume: 13 Page(s): 61 - 62
06/01/2015 Authors: Deng W; Syed AK; Liang X; Lanza F; Li R
Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex.
Blood Volume: 125 Page(s): 562 - 569
01/15/2015 Authors: Zhang W; Deng W; Zhou L; Xu Y; Yang W; Liang X; Wang Y; Kulman JD; Zhang XF; Li R
Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10.
Proc Natl Acad Sci U S A Volume: 111 Page(s): 15987 - 15992
11/11/2014 Authors: Deng W; Cho S; Su P-C; Berger BW; Li R
Specific Inhibition of Ectodomain Shedding of Glycoprotein Ib alpha Improves the Post-transfusion Survival and Hemostatic Function of Stored Human Apheresis Platelets
Volume: 54 Page(s): 90A - 90A
09/01/2014 Authors: Liang X; Syed AK; Jessup P; Josephson CD; Li R
Effects of a Specific Inhibitor of Glycoprotein Ib alpha Shedding on the Function and Survival of Cold-stored Human Apheresis Platelets
Volume: 54 Page(s): 103A - 104A
09/01/2014 Authors: Liang X; Syed A; Jessup P; Josephson CD; Li R
Identification of the mechanosensory domain in the platelet mechanosensor GPIb-IX complex
Volume: 12 Page(s): 74 - 75
06/01/2014 Authors: Zhang W; Deng W; Wang Y; Zhou L; Yang W; Liang X; Cho S; Kulman JD; Zhang XF; Li R
Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.
Blood Volume: 123 Page(s): 3344 - 3353
05/22/2014 Authors: Morioka Y; Casari C; Wohner N; Cho S; Kurata S; Kitano A; Christophe OD; Lenting PJ; Li R; Denis CV
Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex.
J Thromb Haemost Volume: 12 Page(s): 82 - 89
01/01/2014 Authors: Zhou L; Yang W; Li R
Specific inhibition of ectodomain shedding of glycoprotein Ib by targeting its juxtamembrane shedding cleavage site.
J Thromb Haemost Volume: 11 Page(s): 2155 - 2162
12/01/2013 Authors: Liang X; Russell SR; Estelle S; Jones LH; Cho S; Kahn ML; Berndt MC; Bunting ST; Ware J; Li R
Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factorVIII by hydrogen-deuterium exchange mass spectrometry.
J Thromb Haemost Volume: 11 Page(s): 2128 - 2136
12/01/2013 Authors: Sevy AM; Healey JF; Deng W; Spiegel PC; Meeks SL; Li R
FERM domain of moesin desorbs the basic-rich cytoplasmic domain of l-selectin from the anionic membrane surface.
J Mol Biol Volume: 425 Page(s): 3549 - 3562
09/23/2013 Authors: Deng W; Cho S; Li R
Chicken glycoprotein Iba and Ib beta form both GPIb and non-GPIb complexes: implications for the evolution of GPIb-IX
Volume: 11 Page(s): 814 - 814
07/01/2013 Authors: Zhou L; Yang W; Liang X; Li R
Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets.
Blood Volume: 121 Page(s): 4221 - 4230
05/16/2013 Authors: Mou P; Zeng Z; Li Q; Liu X; Xin X; Wannemacher KM; Ruan C; Li R; Brass LF; Zhu L
The organizing principle of the platelet glycoprotein Ib-IX-V complex.
J Thromb Haemost Volume: 11 Page(s): 605 - 614
04/01/2013 Authors: Li R; Emsley J
Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.
PLoS One Volume: 8 Page(s): e62861
01/01/2013 Authors: Deng W; Putkey JA; Li R
Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.
J Thromb Haemost Volume: 10 Page(s): 1875 - 1886
09/01/2012 Authors: Mo X; Liu L; Lpez JA; Li R
Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs.
Biochemistry Volume: 50 Page(s): 10598 - 10606
12/13/2011 Authors: Yan R; Mo X; Paredes AM; Dai K; Lanza F; Cruz MA; Li R
Quaternary Organization of GPIb-IX Complex and Insights Into Bernard-Soulier Syndrome Revealed by the Crystal Structures of GPIb beta Ectodomain and a GPIb beta/GPIX Chimera
Volume: 118 Page(s): 958 - 958
11/18/2011 Authors: McEwan PA; Yang W; Carr KH; Mo X; Zheng X; Li R; Emsley J
Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIb and a GPIb/GPIX chimera.
Blood Volume: 118 Page(s): 5292 - 5301
11/10/2011 Authors: McEwan PA; Yang W; Carr KH; Mo X; Zheng X; Li R; Emsley J
Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding.
J Mol Biol Volume: 411 Page(s): 220 - 233
08/05/2011 Authors: Deng W; Srinivasan S; Zheng X; Putkey JA; Li R
Transmembrane domains are critical to the interaction between platelet glycoprotein v and glycoprotein Ib-IX complex
Volume: 9 Page(s): 69 - 69
07/01/2011 Authors: Mo X; Lopez JA; Li R
L-selectin transmembrane and cytoplasmic domains are monomeric in membranes.
Biochim Biophys Acta Volume: 1808 Page(s): 1709 - 1715
06/01/2011 Authors: Srinivasan S; Deng W; Li R
Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.
Thromb Haemost Volume: 105 Page(s): 21 - 30
01/01/2011 Authors: Zhou Z; Yeh H-C; Jing H; Wang C; Tao Z; Choi H; Aboulfatova K; Li R; Dong J-F
Differential Pathogenesis of Bernard-Soulier Syndrome-Associated Mutations In the Platelet Glycoprotein Ib beta Ectodomain.
Volume: 116 Page(s): 1314 - 1314
11/19/2010 Authors: Yang W; McEwan PA; Mo X; Emsley J; Li R
Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha.
J Biol Chem Volume: 285 Page(s): 32096 - 32104
10/15/2010 Authors: Mo X; Nguyen NX; Mu F-T; Yang W; Luo S-Z; Fan H; Andrews RK; Berndt MC; Li R
A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia.
Blood Volume: 115 Page(s): 914
01/28/2010 Authors: Li R
Binding of platelet glycoprotein Ibbeta through the convex surface of leucine-rich repeats domain of glycoprotein IX.
J Thromb Haemost Volume: 7 Page(s): 1533 - 1540
09/01/2009 Authors: Mo X; Nguyen NX; McEwan PA; Zheng X; Lpez JA; Emsley J; Li R
Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.
Thromb Res Volume: 124 Page(s): 323 - 327
07/01/2009 Authors: Zhou Z; Jing H; Tao Z; Choi H; Aboulfatova K; Moake J; Li R; Dong J-F
Juxtamembrane basic residues in glycoprotein Ibbeta cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.
FEBS Lett Volume: 582 Page(s): 3270 - 3274
10/15/2008 Authors: Mo X; Luo S-Z; Lpez JA; Li R
Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex.
J Mol Biol Volume: 382 Page(s): 448 - 457
10/03/2008 Authors: Luo S-Z; Li R
The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.
J Thromb Haemost Volume: 6 Page(s): 1789 - 1795
10/01/2008 Authors: Mo X; Luo S-Z; Munday AD; Sun W; Berndt MC; Lpez JA; Dong J-F; Li R
Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.
J Thromb Haemost Volume: 5 Page(s): 2494 - 2502
12/01/2007 Authors: Luo S-Z; Mo X; Lpez JA; Li R
Effects of naturally occurring mutations in CUB-1 domain on ADAMTS-13 synthesis, stability and activity.
Volume: 110 Page(s): 218A - 218A
11/16/2007 Authors: Zhou Z; Jing H; Tao Z; Choi H; Aboulfatova K; Li R; Dong J-F
Removing the covalent links between GPIb alpha and GPIb beta hampers binding of von Willebrand factor to GP Ib-IX complex- in CHO cells
Volume: 110 Page(s): 1064A - 1064A
11/16/2007 Authors: Mo X; Luo S-Z; Peng Y; Munday AD; Sun C; Berndt MC; Lopez JA; Dong J-F; Li R
Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet.
Blood Volume: 109 Page(s): 603 - 609
01/15/2007 Authors: Luo S-Z; Mo X; Afshar-Kharghan V; Srinivasan S; Lpez JA; Li R
Dimerization of the transmembrane domain of glycoprotein Ib beta in cell membrane and detergent
Page(s): 435A - 435A
01/01/2007 Authors: Luo S-Z; Srinivasan S; Mo X; Li R
The cytoplasmic domain of glycoprotein Ib beta is critical to surface trafticking of glycoprotein Ib-IX complex.
Volume: 108 Page(s): 440A - 441A
11/16/2006 Authors: Mo X; Lopez JA; Li R
The transmembrane domain of glycoprotein Ibbeta is critical to efficient expression of glycoprotein Ib-IX complex in the plasma membrane.
J Biol Chem Volume: 281 Page(s): 23050 - 23059
08/11/2006 Authors: Mo X; Lu N; Padilla A; Lpez JA; Li R
Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.
Blood Volume: 106 Page(s): 4139 - 4145
12/15/2005 Authors: Tao Z; Peng Y; Nolasco L; Cal S; Lopez-Otin C; Li R; Moake JL; Lpez JA; Dong J-F
A push-pull mechanism for regulating integrin function.
Proc Natl Acad Sci U S A Volume: 102 Page(s): 1424 - 1429
02/01/2005 Authors: Li W; Metcalf DG; Gorelik R; Li R; Mitra N; Nanda V; Law PB; Lear JD; Degrado WF; Bennett JS
Heteromeric and homomeric transmembrane domain associations regulate alpha IIb beta 3 function.
Volume: 104 Page(s): 97A - 98A
11/16/2004 Authors: Li W; Metcalf D; Gorelik R; Li RH; Mitra N; Nanda V; Law PB; Lear JD; DeGrado WF; Bennett JS
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes.
J Biol Chem Volume: 279 Page(s): 26666 - 26673
06/18/2004 Authors: Li R; Gorelik R; Nanda V; Law PB; Lear JD; DeGrado WF; Bennett JS
Structural basis for integrin alphaIIbbeta3 clustering.
Volume: 32 Page(s): 412 - 415
06/01/2004 Authors: Li R; Bennett JS; Degrado WF
Intra- and intermolecular structural rearrangements underlying activation of alphaIIbbeta3 integrin studied at the single-molecule level
Volume: 86 Page(s): 446A - 446A
01/01/2004 Authors: Litvinov R; Mitra N; Li W; Vilaire G; Li RH; Nagaswami C; Shuman H; DeGrado WF; Bennett JS; Weisel JW
The transmembrane domain of the integrin subunit alpha IIb dimerizes in cell membranes.
Volume: 102 Page(s): 50A - 51A
11/16/2003 Authors: Li RH; Gorelik R; Law PB; Lear JD; DeGrado WF; Bennett JS
Activation of the platelet integrin alpha IIb beta 3 by modulation of transmembrane helix associations as measured by force spectroscopy.
Volume: 102 Page(s): 291A - 291A
11/16/2003 Authors: Litvinov R; Mitra N; Vilaire G; Li RH; Shuman H; DeGrado WF; Weisel JW; Bennett JS
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.
Science Volume: 300 Page(s): 795 - 798
05/02/2003 Authors: Li R; Mitra N; Gratkowski H; Vilaire G; Litvinov R; Nagasami C; Weisel JW; Lear JD; DeGrado WF; Bennett JS
Use of phage display to probe the evolution of binding specificity and affinity in integrins.
Protein Eng Volume: 16 Page(s): 65 - 72
01/01/2003 Authors: Li R; Hoess RH; Bennett JS; DeGrado WF
Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy.
Biochemistry Volume: 41 Page(s): 15618 - 15624
12/31/2002 Authors: Li R; Babu CR; Valentine K; Lear JD; Wand AJ; Bennett JS; DeGrado WF
Activation of the platelet integrin alpha IIb beta 3 by thermodynamic modulation of transmembrane helix associations.
Volume: 100 Page(s): 50A - 51A
11/16/2002 Authors: Li RH; Gratkowski H; Mitra N; Vilaire G; Wei L; Lear JD; DeGrado WF; Bennett JS
Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.
Biochemistry Volume: 41 Page(s): 2246 - 2253
02/19/2002 Authors: Li R; Battiste JL; Woodward C
A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.
Biochemistry Volume: 41 Page(s): 2237 - 2245
02/19/2002 Authors: Battiste JL; Li R; Woodward C
The transmembrane and cytoplasmic domains of integrin alpha IIb beta 3 form homo-oligoniers in biological membranes
Volume: 82 Page(s): 528A - 528A
01/01/2002 Authors: Li RH; Bennett JS; DeGrado WF
The transmembrane and cytoplasmic domains of aIIb beta 3 form homo-oligomers in biological membranes.
Volume: 98 Page(s): 513A - 513A
11/16/2001 Authors: Li RH; Bennett JS; DeGrado WF
Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains.
Proc Natl Acad Sci U S A Volume: 98 Page(s): 12462 - 12467
10/23/2001 Authors: Li R; Babu CR; Lear JD; Wand AJ; Bennett JS; DeGrado WF
Evidence that unconstrained integrin alpha IIb beta 3 undergoes intermolecular, rather than intramolecular, interactions in a membrane-like environment.
Volume: 80 Page(s): 352A - 352A
01/01/2001 Authors: Li RH; Babu CR; Lear JD; Wand AJ; Bennett JS; DeGrado WF
Pressure response of protein backbone structure. Pressure-induced amide 15N chemical shifts in BPTI.
Protein Sci Volume: 8 Page(s): 1946 - 1953
10/01/1999 Authors: Akasaka K; Li H; Yamada H; Li R; Thoresen T; Woodward CK
The hydrogen exchange core and protein folding.
Protein Sci Volume: 8 Page(s): 1571 - 1590
08/01/1999 Authors: Li R; Woodward C
The slow-exchange core and protein folding.
Trends Biochem Sci Volume: 23 Page(s): 379 - 381
10/01/1998 Authors: Woodward C; Li R
BPTI core residues required for fast folding
Volume: 74 Page(s): A174 - A174
02/01/1998 Authors: Li R; Woodward C
Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.
Mol Cell Biol Volume: 17 Page(s): 6663 - 6672
11/01/1997 Authors: Ng J; Li R; Morgan K; Simon J
Folding kinetics of mutants BPTI mutants.
Volume: 70 Page(s): MP135 - MP135
02/01/1996 Authors: Li R; Woodward C

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Renhao Li

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