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Raymond Dingledine PhD

  • Department of Pharmacology & Chemical Biology
    Adjunct Professor
  • Emory University School of Medicine
    Pharmacology
    1510 Clifton Rd. , Room 5001
Head shot of Raymond Dingledine

Overview

Glutamate receptors mediate the vast majority of excitatory synaptic transmission in the brain. A major research effort is focused on regulation of glutamate receptor-mediated synaptic transmission in the brain by the co-activation of selected G-protein coupled receptors. A second research emphasis involves the use of microarray and associated technologies to identify novel targets and pathways involved in the basic cellular and molecular mechanisms of epilepsy. These research interests converge and have highlighted a role for cyclooxygenase-2 (COX2) signaling pathways in the cognitive deficits, impaired synaptic inhibition, and eurodegeneration caused by seizures. We are currently exploring the consequences of conditional COX2 knockouts and are seeking the prostaglandin receptors responsible for each of these effects; we are employing a chemical biology approach to develop novel small molecule modulators of these receptors in an effort to interrupt the development of epilepsy. As a whole our work integrates information from a variety of experimental strategies to contribute to a better understanding of epilepsy, with broad implications for other brain disorders including stroke and schizophrenia.

Academic Appointment

  • Professor and Chairman, Dept. Pharmacology, Emory University School of Medicine
  • Research Associate, Dept. of Physiology, Duke University

Education

Degrees

  • PhD from Stanford University
  • BS from Michigan State University

Research

Publications

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